361,591 results match your criteria Down Syndrome


Synthesis of fly ash based zeolite-reduced graphene oxide composite and its evaluation as an adsorbent for arsenic removal.

Chemosphere 2018 Dec 4;219:504-509. Epub 2018 Dec 4.

School of Engineering, Indian Institute of Technology, Mandi, 175005, Himachal Pradesh, India. Electronic address:

A zeolite-reduced graphene oxide (ZrGO) based composite was synthesized to remove arsenic from water. To make a low-cost adsorbent, zeolite was synthesized using an inexpensive waste material; fly ash, which was further used to produce the ZrGO composite. Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), and Raman spectra were used to characterize the morphology and surface composition of the synthesized materials. Read More

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December 2018

Proteomic analysis for phenanthrene-elicited wheat chloroplast deformation.

Environ Int 2018 Dec 11;123:273-281. Epub 2018 Dec 11.

Stockbridge School of Agriculture, University of Massachusetts, Amherst, MA 01003, USA.

The exposure of polycyclic aromatic hydrocarbons (PAHs) can cause wheat leaf chlorosis. Thus, we hypothesize that chloroplast inner structure damage is the reason for leaf chlorosis. This study was conducted with the wheat seedlings exposed to Hoagland nutrient solution containing 1. Read More

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December 2018
3 Reads

Attentional priming: recent insights and current controversies.

Curr Opin Psychol 2018 Nov 28;29:71-75. Epub 2018 Nov 28.

Icelandic Vision Laboratory, School of Humanitites and Social Sciences, University of Akureyri. Hafnarstræti 97, Akureyri IS600, Iceland.

Humans possess a primitive memory system for attention deployments that allows quick reorientation of visual attention to stimuli that are relevant to behavior at any given moment. We review recent evidence regarding such attentional priming effects from a number of different perspectives. We discuss recent findings on the time course and duration of such effects, the potential interaction of priming and top-down attentional guidance; how priming can be used to probe the nature of visual representations and attentional templates; findings on the basic nature of priming effects and recent relevant findings on so-called serial dependencies that share many characteristics with attentional priming. Read More

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November 2018
1 Read

Cladophora glomerata methanolic extract decreases oxidative stress and improves viability and mitochondrial potential in equine adipose derived mesenchymal stem cells (ASCs).

Biomed Pharmacother 2018 Dec 12;111:6-18. Epub 2018 Dec 12.

Department of Experimental Biology, Faculty of Biology and Animal Science, Wrocław University of Environmental and Life Sciences, Norwida 27B, 50-375 Wrocław, Poland; Faculty of Veterinary Medicine, Equine Clinic - Equine Surgery, Justus-Liebig-University, 35392 Gießen, Germany. Electronic address:

Reactive oxygen species (ROS) are key mediators of several cellular damage and thus associated with equine diseases such as inflammation and metabolic syndrome. This study aimed to evaluate the protective and antioxidant activities of methanolic extract prepared from Cladophora glomerata (C. glomerata) biomass, on equine adipose derived mesenchymal stem cells (EqASCs), under experimental oxidative stress induced by HO. Read More

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December 2018

Improved anti-colorectal carcinomatosis effect of tannic acid co-loaded with oxaliplatin in nanoparticles encapsulated in thermosensitive hydrogel.

Eur J Pharm Sci 2018 Dec 12. Epub 2018 Dec 12.

State Key Laboratory of Biotherapy and Cancer Center and Department of Neurosurgery, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, PR China. Electronic address:

Tannic acid, a hydrolysable tannin, exists commonly in food plants. Tannic acid has already been shown various anticancer mechanisms such as inhibiting the proliferation, inducing a higher apoptotic rate and slowing down the metastasis of different cancers. Moreover, tannic acid was reported to reduce the side effects caused by chemotherapeutics on patients. Read More

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December 2018

Automated small-scale in vitro transfer model as screening tool for the prediction of in vivo-dissolution and precipitation of poorly solubles.

Int J Pharm 2018 Dec 12. Epub 2018 Dec 12.

Institute of Pharmacy, Department of Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, Felix-Hausdorff-Strasse 3, 17489 Greifswald, Germany. Electronic address:

Precipitation testing, especially for weakly basic APIs, represents a key parameter in drug substance characterization during early development stages, where the amount of API available is limited. Therefore, it was the aim of this study to develop an automated small-scale in vitro transfer model to characterize the supersaturation and precipitation behavior of two poorly water-soluble drugs. Following automation and scale-down of the standard transfer model, the developed small-scale model was used to assess the impact of gastrointestinal variability, i. Read More

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December 2018

A potential regulatory network among WDR86-AS1, miR-10b-3p, and LITAF is possibly involved in preeclampsia pathogenesis.

Cell Signal 2018 Dec 12. Epub 2018 Dec 12.

Department of Obstetrics and Gynecology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, PR China.

Preeclampsia (PE), a pregnancy-specific disorder, is a leading cause of perinatal maternal and fetal mortality and morbidity. Impaired migration and invasion of trophoblastic cells and an imbalanced systemic maternal inflammatory response have been proposed as possible causes of pathogenesis of PE. Comparative analysis of PE-affected placentas and healthy placentas has uncovered differentially expressed long noncoding RNAs, microRNAs, and mRNAs. Read More

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December 2018

FH535 inhibits proliferation and migration of colorectal cancer cells by regulating CyclinA2 and Claudin1 gene expression.

Gene 2018 Dec 12. Epub 2018 Dec 12.

Wenzhou Medical University School of Laboratory Medicine and Life Sciences, Wenzhou 325000, China. Electronic address:

Wnt signaling pathway plays a major role in the progression of colorectal cancer (CRC). Small molecules which can cut off this signal transduction can be promising anti-cancer drugs for CRC therapy. Therefore, we aimed to investigate the mechanisms of FH535, an inhibitor of the Wnt signaling pathway, on inhibiting proliferation and migration of colorectal cancer cells DLD-1 and SW620. Read More

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December 2018
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Morus alba L. Diminishes visceral adiposity, insulin resistance, behavioral alterations via regulation of gene expression of leptin, resistin and adiponectin in rats fed a high-cholesterol diet.

Physiol Behav 2018 Dec 12. Epub 2018 Dec 12.

Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt. Electronic address:

Ethanolic extract of leaves of Morus alba L. (M. alba), known as white mulberry, was orally administered (100 mg/kg b. Read More

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December 2018

Baicalin alleviates 6-hydroxydopamine-induced neurotoxicity in PC12 cells by down-regulation of microRNA-192-5p.

Brain Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China. Electronic address:

Parkinson's disease (PD), which was caused by neurodegenerative disorder, has no effective treatment until now. Baicalin was reported to have neuroprotective effects. Hence, we investigated the effects of baicalin on PD in an in vitro cell model by using 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in rat pheochromocytoma PC12 cells. Read More

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December 2018

Inhibition of SIRT1 by microRNA-9, the key point in process of LPS-induced severe inflammation.

Arch Biochem Biophys 2018 Dec 12. Epub 2018 Dec 12.

Department of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University, 127 Changle West Road, Xi'an, Shaanxi, 710032, China. Electronic address:

Severe inflammation may lead to multiple organs dysfunction syndrome, which has a high mortality. MicroRNA is found participated in this process. In this study we developed a lipopolysaccharide-induced inflammation cell model on macrophages and a lipopolysaccharide-induced inflammation mouse model. Read More

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December 2018
1 Read

Dual use in the 21st century: emerging risks and global governance.

Swiss Med Wkly 2018 Nov 2;148:w14688. Epub 2018 Dec 2.

Health Ethics and Policy Lab, Department of Health Sciences and Technology, ETH Zurich, Switzerland.

Dual use research of concern (DURC) is defined by the World Health Organization as "life sciences research that is intended for benefit, but which might easily be misapplied to do harm." Ethical and policy discussions on DURC span the past three decades. Today, however, new and emerging technologies and associated sociocultural transformations within the scientific community are reshaping the current risk scenario. Read More

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November 2018
2 Reads

Myosin Heavy Chain 10 (MYH10) Gene Silencing Reduces Cell Migration and Invasion in the Glioma Cell Lines U251, T98G, and SHG44 by Inhibiting the Wnt/β-Catenin Pathway.

Med Sci Monit 2018 Dec 15;24:9110-9119. Epub 2018 Dec 15.

Department of Neurosurgery, Suizhou Central Hospital, Suizhou, Hubei, China (mainland).

BACKGROUND The myosin heavy chain 10 or MYH10 gene encodes non-muscle myosin II B (NM IIB), and is involved in tumor cell migration, invasion, extracellular matrix (ECM) production, and epithelial-mesenchymal transition (EMT). This study aimed to investigate the effects of the MYH10 gene on normal human glial cells and glioma cell lines in vitro, by gene silencing, and to determine the signaling pathways involved. MATERIAL AND METHODS The normal human glial cell line HEB, and the glioma cell lines, U251, T98G, and SHG44 were studied. Read More

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December 2018
2 Reads

Tumor Necrosis Factor Related Apoptosis Inducing Ligand reduces the expression of the neuroprotective Na /Ca exchanger isoform NCX3 in human neuroblastoma SH-SY5Y cells.

FEBS J 2018 Dec 15. Epub 2018 Dec 15.

Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, University of Catania School of Medicine, Catania, Italy.

Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL), a cytokine belonging to the TNF superfamily, is regarded as a mediator of neurotoxicity. The constitutively expressed ion exchanger NCX3 has been shown to protect neurons from injury. Its expression is induced by Nerve growth factor (NGF) through activation of its tyrosine kinase receptor trkA. Read More

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December 2018

PAR2 promotes M1 macrophage polarization and inflammation via FOXO1 pathway.

J Cell Biochem 2018 Dec 14. Epub 2018 Dec 14.

Department of Physiology & Pathophysiology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.

Macrophages polarization plays essential but different roles in most diseases such as atherosclerosis, adipose tissue inflammation, and insulin resistance. Our previous study revealed that protease-activated receptor 2 (PAR2), a G-protein coupled receptor influenced macrophage function, but little is known regarding the regulation of macrophage polarization process and its potential mechanisms. In the present study, bone marrow-derived macrophages (BMDM) isolated from C57/BL6 mice and cultured with L929-conditional medium and murine macrophage cell line RAW264. Read More

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December 2018
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A newly synthesized oleanolic acid derivative inhibits the growth of osteosarcoma cells in vitro and in vivo by decreasing c-MYC-dependent glycolysis.

J Cell Biochem 2018 Dec 14. Epub 2018 Dec 14.

Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Osteosarcoma (OS) is the primary malignant bone tumor with a peak incidence in children and adolescents. However, the little molecular mechanism of pathogenesis has been known and it is urgent to develop new therapeutical strategies to improve outcomes for patients. CDDO-NFM (N-formylmorpholine substituent of CDDO) is a newly synthesized triterpenoid, which is a derivative of oleanolic acid. Read More

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December 2018

Moonshot to Cancer Cure: Recruiting Policy to Break Down Silos.

Cancer Treat Res 2019 ;171:119-128

Robert H. Lurie Comprehensive Cancer Center, Survivorship Institute, Northwestern University, Chicago, IL, 60611, USA.

Funded by the 21 Century Cures Act, The Beau Biden Cancer Moonshot Initiative is broad, deep, integrative, and intended to expediently address cancer's most vexing problems. Launched in 2015, it is an effort to accelerate the pace of cancer research with a focus on breaking down silos through cross-pollination of research, recruitment of multidisciplinary clinical and basic science research teams, sharing of complex scientific databases, and the creation of public-private research partnerships. This audacious approach to cancer treatment is intended to alleviate the current burden of cancer within countries and across borders. Read More

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January 2019
1 Read

FcRγ deficiency improves survival in experimental sepsis by down-regulating TLR4 signaling pathway.

Immunol Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Oncology, General Hospital of Chinese PLA, 28 Fuxing Road, Beijing, 100853, China.

Fc receptor common γ signaling chain (FcRγ), a common subunit shared by Fc receptors (FcγRI, III, IV, FcαRI, and FcεRI), is an important immune regulator both in innate and adaptive immunity. Previous studies have shown that FcRγ was a potential target of inflammatory diseases, whereas the role of FcRγ in sepsis has been poorly understood. In this study, we found that deficiency of FcRγ resulted in increased survival in lipopolysaccharide (LPS)/D-galactosamine and E. Read More

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December 2018

Sex differences in somatomotor representations of others' pain: a permutation-based analysis.

Brain Struct Funct 2018 Dec 14. Epub 2018 Dec 14.

Ahmanson-Lovelace Brain Mapping Center, Brain Research Institute, UCLA, Los Angeles, CA, USA.

Sex differences in empathy for pain have been repeatedly observed. However, it is unclear whether this is due to sex differences in "bottom-up" somatomotor representations of others' pain (self-other resonance) or to "top-down" prefrontal control of such responses. Here, we provide data from 70 subjects suggesting that sex differences in empathy for pain lie primarily in pre-reflective, bottom-up resonance mechanisms. Read More

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December 2018

JPlogP: an improved logP predictor trained using predicted data.

J Cheminform 2018 Dec 14;10(1):61. Epub 2018 Dec 14.

Lhasa Limited, Granary Wharf House, 2 Canal Wharf, Leeds, LS11 5PS, UK.

The partition coefficient between octanol and water (logP) has been an important descriptor in QSAR predictions for many years and therefore the prediction of logP has been examined countless times. One of the best performing models is to predict the logP using multiple methods and average the result. We have used those averaged predictions to develop a training-set which was able to distil the information present across the disparate logP methods into one single model. Read More

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December 2018

High Speed Pneumatic Stepper Motor for MRI Applications.

Ann Biomed Eng 2018 Dec 14. Epub 2018 Dec 14.

School of Electrical and Computer Engineering, University of Georgia, Athens, GA, USA.

Presented in this paper is an exploration into the efficacy of a plastic, four-cylinder piston pneumatic motor designed for driving medical instruments inside magnetic resonance imaging (MRI) systems. Because of the increasing use of MRI for diagnostic and interventional purposes and the benefits that could be realized by operating with real-time MR image guidance, there exists a significant need for MRI compliant surgical devices. Some type of actuation mechanism is necessary to drive such devices. Read More

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December 2018
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Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells.

Oncogene 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Experimental Medicine, Centre of New Technologies, University of Warsaw, Warsaw, Poland.

Metastasis to distant organs is a major cause for solid cancer mortality, and the acquisition of migratory and invasive phenotype is a key factor in initiation of malignancy. In this study we investigated the contribution of Mixed-Lineage Kinase 4 (MLK4) to aggressive phenotype of breast cancer cells. Our TCGA cancer genomic data analysis revealed that amplification or mRNA upregulation of MLK4 occurred in 23% of invasive breast carcinoma cases. Read More

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December 2018

On the role of eye contact in gaze cueing.

Sci Rep 2018 Dec 14;8(1):17842. Epub 2018 Dec 14.

Istituto Italiano di Tecnologia, Social Cognition in Human-Robot Interaction, via Enrico Melen 83, 16152, Genova, Italy.

Most experimental protocols examining joint attention with the gaze cueing paradigm are "observational" and "offline", thereby not involving social interaction. We examined whether within a naturalistic online interaction, real-time eye contact influences the gaze cueing effect (GCE). We embedded gaze cueing in an interactive protocol with the iCub humanoid robot. Read More

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December 2018
2 Reads

Identification of cytochrome P450 monooxygenase genes and their expression in response to high temperature in the alligatorweed flea beetle Agasicles hygrophila (Coleoptera: Chrysomelidae).

Sci Rep 2018 Dec 14;8(1):17847. Epub 2018 Dec 14.

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.

Cytochrome P450 monooxygenases (P450s) are a large class of enzymes that play essential roles in metabolic processes such as hormone synthesis and the catabolism of toxins and other chemicals in insects. In the present study, we identified 82 P450 genes using comprehensive RNA sequencing in the flea beetle Agasicles hygrophila, and all of the sequences were validated by cloning and sequencing. Phylogenetic analysis showed that the P450 genes in A. Read More

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December 2018

Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma.

Nat Commun 2018 Dec 14;9(1):5331. Epub 2018 Dec 14.

Posttranscriptional Gene Regulation, Cancer Research and Experimental Haemostasis, University Medical Centre Mainz, Mainz, 55131, Germany.

Diversification at the transcriptome 3'end is an important and evolutionarily conserved layer of gene regulation associated with differentiation and dedifferentiation processes. Here, we identify extensive transcriptome 3'end-alterations in neuroblastoma, a tumour entity with a paucity of recurrent somatic mutations and an unusually high frequency of spontaneous regression. Utilising extensive RNAi-screening we reveal the landscape and drivers of transcriptome 3'end-diversification, discovering PCF11 as critical regulator, directing alternative polyadenylation (APA) of hundreds of transcripts including a differentiation RNA-operon. Read More

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December 2018

Characterizing Activity and Thermostability of GH5 Endoglucanase Chimeras from Mesophilic and Thermophilic Parents.

Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.

From the Key Laboratory for Feed Biotechnology of the Ministry of Agriculture, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, People's Republic of China

Cellulases from glycoside hydrolase (GH) family 5 are key endoglucanase enzymes in the degradation of diverse polysaccharide substrates and are used in industrial enzyme cocktails to break down biomass. The GH5 family shares a canonical (βα)-barrel structure, where each (βα) module is essential for the enzyme stability and activity. Despite their shared topology, the thermostability of GH5 endoglucanase enzymes can vary significantly, and highly thermostable variants are often sought for industrial applications. Read More

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December 2018

Co-repressor, co-activator and general transcription factor: the many faces of the Sin3 histone deacetylase (HDAC) complex.

Biochem J 2018 Dec 14;475(24):3921-3932. Epub 2018 Dec 14.

Department of Molecular and Cell Biology, University of Leicester, Leicester LE1 7RH, U.K.

At face value, the Sin3 histone deacetylase (HDAC) complex appears to be a prototypical co-repressor complex, that is, a multi-protein complex recruited to chromatin by DNA bound repressor proteins to facilitate local histone deacetylation and transcriptional repression. While this is almost certainly part of its role, Sin3 stubbornly refuses to be pigeon-holed in quite this way. Genome-wide mapping studies have found that Sin3 localises predominantly to the promoters of actively transcribed genes. Read More

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December 2018

Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5.

Biol Open 2018 Dec 14;7(12). Epub 2018 Dec 14.

Department of Biochemical and Molecular Sciences, Queen's University, Kingston, Ontario, K7L 3N6, Canada

Phosphoenolpyruvate carboxykinase (PEPCK1) is ubiquitinated by E3 ubiquitin ligase UBR5, which was thought to be facilitated by the acetylation of Lys70, Lys71 and Lys594 in PEPCK1. Here, we made a series of UBR5 HECT domain truncation variants and, through pull-down assay, showed that the N-terminal lobe of the UBR5 HECT domain is largely responsible for interacting with PEPCK1. We mutated all three lysine residues thought to be acetylated in PEPCK1 but were surprised to observe no loss of binding to UBR5 HECT domain. Read More

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December 2018

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Sci Immunol 2018 Dec;3(30)

Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

Tissue-resident memory T cells (T) are noncirculating immune cells that contribute to the first line of local defense against reinfections. Their location at hotspots of pathogen encounter frequently exposes T to tissue damage. This history of danger-signal exposure is an important aspect of T-mediated immunity that has been overlooked so far. Read More

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December 2018

Cold evoked potentials: Acquisition from cervical dermatomes.

Neurophysiol Clin 2018 Dec 11. Epub 2018 Dec 11.

Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Forchstrasse 340, 8008 Zurich, Switzerland. Electronic address:

Introduction: Cold evoked potentials (CEPs) represent a novel technique to assess the integrity of cold-specific pathways within the somatosensory system. So far an objective assessment of these pathways has not been implemented into the clinical routine. Specifically, CEPs may help to elucidate the pathophysiological underpinnings of altered cold processing in neurological diseases. Read More

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December 2018
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Adherence to low carbohydrate diet in relation to glioma: A case-control study.

Clin Nutr 2018 Nov 30. Epub 2018 Nov 30.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran; Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Observational studies that investigated the association between adherence to low carbohydrate diet and odds of glioma are sparse. This is particularly relevant in developing countries where dietary carbohydrate intake is very high.

Objective: This study was, therefore, conducted to investigate the association between adherence to low carbohydrate dietary pattern and odds of glioma among Iranian adults. Read More

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November 2018
4.476 Impact Factor

Long noncoding RNA H19 promotes vascular remodeling by sponging let-7a to upregulate the expression of cyclin D1.

Biochem Biophys Res Commun 2018 Dec 11. Epub 2018 Dec 11.

Department of Vascular Surgery, The First Hospital of China Medical University, Shenyang, 110001, China. Electronic address:

Vascular remodeling is mainly caused by excessive proliferation of vascular smooth muscle cells (VSMCs). Noncoding RNAs (ncRNAs) have emerged as important regulators in diverse pathological processes. Previous work has shown the functions and mechanisms of long noncoding RNA H19 (LncRNA H19) on VSMCs. Read More

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December 2018

Routine intensive care unit admission among patients undergoing major pancreatic surgery for cancer: No effect on failure to rescue.

Surgery 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgery, The Ohio State University Wexner Medical Center, Columbus. Electronic address:

Background: An understanding of the overall routine intensive care unit utilization, and characterization of the factors associated with a routine intensive care unit stay, may help identify ways to decrease overutilization of this resource after pancreatic surgery.

Methods: Patients undergoing major pancreatic resection were identified in the Truven Health Analytics (Ann Arbor, MI) MarketScan Commercial Claims and Encounters Database from 2010 to 2014. Routine postoperative intensive care unit admission was defined as an admission to the intensive care unit of 24 hours or less on postoperative day zero. Read More

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December 2018

Environmental correlates of total and domain-specific sedentary behaviour in young people. The UP&DOWN study.

Eur J Sport Sci 2018 Dec 14:1-11. Epub 2018 Dec 14.

a Department of Physical Education, Sport and Human Movement , Autonomous University of Madrid , C/ Francisco Tomás y Valiente, 3, 28049 , Madrid , Spain.

This study investigated the associations between the characteristics of the nearby physical environment with the total and domain-specific leisure-time sedentary behaviour (SB) in young people. The study included 1578 youth (9-18 years) from the UP&DOWN study. Total leisure-time SB was objectively-assessed by accelerometers. Read More

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December 2018

Downregulation of EIF5A2 by miR-221-3p inhibits cell proliferation, promotes cell cycle arrest and apoptosis in medulloblastoma cells.

Biosci Biotechnol Biochem 2018 Dec 14:1-9. Epub 2018 Dec 14.

a Department of Neurosurgery , The First Affiliated Hospital of Yangtze University , Jingzhou , Hubei Province , China.

Recently, miR-221-3p expression has been reported to be down-regulated in medulloblastoma (MB), but its functional effects remains unclear. In this study, quantitative real-time PCR (qRT-PCR) revealed significantly decreased miR-221-3p in MB cell lines. Transfection of miR-221-3p mimics reduced, or inhibitor increased cell proliferation in MB cells using MTT assay. Read More

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December 2018
1 Read

Optimization Design Method of a New Stabilized Platform Based on Missile-borne Semi-Strap-down Inertial Navigation System.

Sensors (Basel) 2018 Dec 13;18(12). Epub 2018 Dec 13.

Key Laboratory of Biomimetic Robots and Systems, Beijing Institute of Technology, Ministry of Education, Beijing 100081, China.

At present, existing wide range Micro-Electro-Mechanical-Systems (MEMS) inertial sensors have relatively lower precision and direct measurement of the missile's high-rotation motion inevitably uses a large-range sensor. To achieve high-precision navigation, this paper proposes a novel Semi-strap-down Stabilized Platform (SSP) based on the Missile-borne Semi-Strap-down Inertial Navigation System, which is used to mount sensors and lowers sensor range requirements through isolating the high-rotational motion of missile. First, the author innovatively puts forward a dynamic model under missile-borne environment, then analyses the influence of SSP quality on the range of gyro according to the dynamic model of the SSP. Read More

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December 2018

Regulatory Efficacy of Protease Hydrolyzate on Lipid Metabolism and Gut Microbiota in High-Fat Diet-Fed Rats.

Int J Mol Sci 2018 Dec 13;19(12). Epub 2018 Dec 13.

National Engineering Research Center of JUNCAO Technology, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Lipid metabolism disorder (LMD) is a public health issue. is a widely used natural weight-reducing agent and is a kind of protein source. In the present study, we aimed to evaluate the effect of protease hydrolyzate (SPPH) on the lipid metabolism and gut microbiota in high-fat diet (HFD)-fed rats. Read More

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December 2018

MiR-148a suppressed cell invasion and migration via targeting WNT10b and modulating β-catenin signaling in cisplatin-resistant colorectal cancer cells.

Biomed Pharmacother 2019 Jan 5;109:902-909. Epub 2018 Nov 5.

Department of Pediatrics, Renmin Hospital of Wuhan University, Jiefang Road 238, Wuhan 430060, China. Electronic address:

Cancer stem cells (CSCs) are suggested to be responsible for high recurrence rate and metastasis of colorectal cancer (CRC). Identifying novel targets that can suppress CSCs proliferation and metastasis may provide novel approach to combat against CRC. In the present study, we examined the role of miR-148a in cisplatin-resistant CRC cells with enhanced stem cell marker expression and explored the underlying mechanisms. Read More

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January 2019

Expression profile of maternal circulating microRNAs as non-invasive biomarkers for prenatal diagnosis of congenital heart defects.

Biomed Pharmacother 2019 Jan 5;109:823-830. Epub 2018 Nov 5.

Key Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital, China Medical University, Shenyang, China. Electronic address:

Objective: The discovery of cell free fetal microRNAs (miRNAs) in maternal circulation has opened up novel probabilities for non-invasive prenatal diagnosis. This study aims to investigate circulating miRNAs as potential biomarkers in the serum of pregnant women with congenital heart defect (CHD) fetuses.

Method: A total of 110 pregnant women including 50 CHD cases and 60 healthy controls were included in this study. Read More

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January 2019

Knockdown of lncRNA-H19 inhibits cell viability, migration and invasion while promotes apoptosis via microRNA-143/RUNX2 axis in retinoblastoma.

Biomed Pharmacother 2019 Jan 5;109:798-805. Epub 2018 Nov 5.

Department of Ophthalmology, Linyi Central Hospital, Linyi 276400, Shandong, China. Electronic address:

Background: Even though the role of long non-coding RNA H19 (lncRNA-H19) in diverse cancer types has been studied, exact effect of lncRNA-H19 as well as the underlying mechanism in retinoblastoma (RB) is poorly reported. We aimed to explore the possible functions of lncRNA-H19 in human RB Y79 cells.

Methods: LncRNA-H19 in Y79 cells was silenced, and effects of lncRNA-H19 silence on cell viability, migration and invasion, and apoptosis were analyzed by using trypan blue exclusion, Transwell assay, and flow cytometry assay/Western blot analysis, respectively. Read More

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January 2019

Effects of 5-Aza on p-Y1472 NR2B related to learning and memory in the mouse hippocampus.

Biomed Pharmacother 2019 Jan 5;109:701-707. Epub 2018 Nov 5.

Inner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou Medical College, Inner Mongolia, People's Republic of China; Biomedicine Research Center, Basic Medical College and Baotou Medical College of Neuroscience Institute, Baotou Medical College, Inner Mongolia, People's Republic of China; Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, People's Republic of China. Electronic address:

Background: We have previously reported that 5-Aza-2-deoxycytidine (5-Aza-cdR) can repress protein serine/threonine phosphatase-1γ (PP1γ) expression and activity in the mouse hippocampus and affect the behaviour of mice in a water maze. It is well known that the phosphorylation of N-methyl-d-aspartate receptor 2B subunit (NR2B) plays a role in behaviour. In this study, we examined whether 5-Aza-cdR affects NR2B phosphorylation at tyrosine 1472 (p-Y1472 NR2B) and whether it affected the responses of the mice in a passive avoidance test. Read More

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January 2019

SRPX2 knockdown inhibits cell proliferation and metastasis and promotes chemosensitivity in esophageal squamous cell carcinoma.

Biomed Pharmacother 2019 Jan 5;109:671-678. Epub 2018 Nov 5.

The First Ward, Department of Cardiothoracic and Vascular Surgery, Huaihe Hospital of Henan University, Kaifeng 475000, China. Electronic address:

Sushi repeat-containing protein X-linked 2 (SRPX2), a chondroitin sulfate proteoglycan, functions as a critical regulator in several types of malignancy. However, its expression and biological functions in esophageal squamous cell carcinoma (ESCC) remain unclear. Thus, the objective of this paper was to investigate the expression pattern and biological functions of SRPX2 in ESCC. Read More

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January 2019

Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-γ and NF-κB.

Biomed Pharmacother 2019 Jan 1;109:2472-2481. Epub 2018 Dec 1.

Molecular and Clinical Pharmacology Program, Institute of Biomedical Science, Faculty of Medicine, University of Chile, Santiago, Chile.

Background: White adipose tissue (WAT) have a relevant metabolic and inflammatory function, in overweight or obesity conditions. In this regard, the WAT under over feeding nutrition present a significant increment in oxidative stress, pro-inflammatory status and depletion of n-3 long chain polyunsaturated fatty acid. Hydroxytyrosol (HT) is a polyphenol with important cytoprotective effects, and this molecule can modulate the gene expression, transcription factors and enzymatic activity. Read More

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January 2019
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ACY-1215 exhibits anti-inflammatory and chondroprotective effects in human osteoarthritis chondrocytes via inhibition of STAT3 and NF-κB signaling pathways.

Biomed Pharmacother 2019 Jan 1;109:2464-2471. Epub 2018 Dec 1.

Department of Orthopaedics, The Fourth Affiliated Hospital of Anhui Medical University, 372#Tun Xi Road, Hefei, 230032, Anhui, China. Electronic address:

Cartilage degeneration is a basic pathological feature of osteoarthritis (OA), and there is growing evidence that it is associated with inflammation. ACY-1215, a selective HDAC6 inhibitor, has been reported to have anti-inflammatory effects. Here, we investigated the anti-inflammatory and chondroprotective effects of ACY-1215 in IL-1β-stimulated human primary chondrocytes and C28/I2 cells. Read More

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January 2019

Icariin inhibits cell proliferation, migration and invasion by down-regulation of microRNA-625-3p in thyroid cancer cells.

Biomed Pharmacother 2019 Jan 1;109:2456-2463. Epub 2018 Dec 1.

Department of Thyroid and Breast Surgery, Jining No. 1 People's Hospital, Jining 272011, Shandong, China. Electronic address:

Thyroid cancer (TC) is a familiar cancer, which accounts for approximately 1% of the malignant tumors of all cancers worldwide. Recently, icariin (ICA) has been reported to play an anti-tumor role in different cancers. The study aimed to investigate the effect of ICA on TC cells to uncover the regulatory mechanism. Read More

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January 2019

Zerumbone inhibits migration in ESCC via promoting Rac1 ubiquitination.

Biomed Pharmacother 2019 Jan 1;109:2447-2455. Epub 2018 Dec 1.

Henan Key Laboratory of Cancer Epigenetics, Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan University of Science and Technology, 24 Jinghua Road, Jianxi Qu, Luoyang, 471003, PR China. Electronic address:

Zerumbone has been reported to maintain the anti-cancer effects in many malignant cells. However, the effect and mechanism of Zerumbone on esophageal squamous cell carcinomas (ESCC) is rarely investigated. Here we report the inhibitory effect of Zerumbone (hereinafter referred to as ZER) on ESCC migration and the underlying molecular mechanism. Read More

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January 2019

mircroRNA-152 prevents the malignant progression of atherosclerosis via down-regulation of KLF5.

Biomed Pharmacother 2019 Jan 30;109:2409-2414. Epub 2018 Nov 30.

Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. Electronic address:

Macrophages' function play a vital role in the progression of atherosclerosis (AS), and miRNAs can modulate inflammatory cytokine secretion, lipid uptake and apoptosis of macrophages. miR-152 is down-regulated in the serum samples of AS patients and inhibits the migration of human umbilical vein endothelial cell, suggesting that miR-152 exerts a role in the atherogenesis. Nevertheless, the function of miR-152 in the inflammatory reaction of macrophages remains unexplored. Read More

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January 2019
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Alpinia oxyphylla oil induces apoptosis of hepatocellular carcinoma cells via PI3K/Akt pathway in vitro and in vivo.

Biomed Pharmacother 2019 Jan 30;109:2365-2374. Epub 2018 Nov 30.

Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; Department of Pharmacy, General Hospital of Shenyang Military Area Command, Shenyang 110840, China. Electronic address:

Background: The anti-tumor properties of Alpinia oxyphylla Miquel (A. oxyphylla) extracts and their petroleum ether (PE) fractions have long attracted scientific attention. These extracts' anti-tumor activity and mechanisms in vivo are still unclear. Read More

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January 2019
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Hsa-let-7g promotes osteosarcoma by reducing HOXB1 to activate NF-kB pathway.

Biomed Pharmacother 2019 Jan 29;109:2335-2341. Epub 2018 Nov 29.

Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, PR China.

MicroRNA (miRNA) is known to be involved in regulating the proliferation, migration and apoptosis of cancer cells in osteosarcoma. In this study, We aim to explore the expression of hsa-let-7 g and its role in pathogenesis of osteosarcoma. By analyzing clinical data. Read More

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January 2019