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Front Neurol 2021 7;12:673974. Epub 2021 Jun 7.

Department of Otolaryngology, University Hospital of Getafe, Madrid, Spain.

To evaluate the different peripheral, neurological, genetic, and systemic etiologies of bilateral vestibulopathy (BVP) and the value of vHIT in the diagnostic process. A retrospective case review was performed on 176 patients diagnosed with BVP in a tertiary referral center, between 2010 and 2020. Inclusion criteria comprised imbalance and/or oscillopsia during locomotion and horizontal angular VOR gain on both sides <0. Read More

Drugs Aging 2021 Jun 23. Epub 2021 Jun 23.

Department of Surgical Pathology, Medical, Molecular and Critical Area, ENT Section, Pisa University Hospital, Via Paradisa, 2, 56126, Pisa, Italy.

The number of older people has been increasing over recent decades in Western populations. Dizziness, imbalance, and vertigo constitute some of the most common complaints in older patients, and risk of falling is the most frequent and worrying consequence. It has been reported that 15-20% of the adult population experiences these debilitating symptoms. Read More

J Clin Neurosci 2021 Jul 12;89:161-164. Epub 2021 May 12.

Stroke Unit, Centre Hospitalier Sud-Francilien, Corbeil-Essonnes, France.

Background: Isolated cerebellar nodulus infarction (ICNI) is rare and has great clinical similarity with acute peripheral vestibulopathy (APV), from which it is difficult to distinguish. We report two cases of ICNI followed by a literature review to identify the discriminant clinical elements that differentiate ICNI from APV.

Methods: We describe in detail our 2 cases. Read More

Otol Neurotol 2021 Jul;42(6):897-905

Department of Otolaryngology-Head and Neck Surgery, Hospital of the University of Pennsylvania.

Objective: To characterize differences in vestibular testing results among patients presenting with balance-related complaints; to stratify patterns of testing abnormalities by age.

Study Design: Retrospective chart review.

Setting: Academic Balance Center at a Tertiary Referral Center. Read More

J Neurol 2021 Jun 9. Epub 2021 Jun 9.

Department of Neuroscience, Institute of Health Sciences, Dokuz Eylül University, İzmir, Turkey.

Background: Vestibular migraine (VM) is one of the most common causes of vertigo in clinical practice but it is not always easy to make the correct diagnosis. Our aims were to find out how VM patients differ from migraine only (MO) patients, to evaluate co-morbid depression in these two groups and to determine if their disease has an effect on their quality of life.

Methods: We studied 50 definite VM and 35 MO patients. Read More

BMC Neurol 2021 May 8;21(1):186. Epub 2021 May 8.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119, South 4th Ring West Road, Fengtai District, Beijing, 100070, China.

Background: When dizziness/vertigo patients presented with balance disorder, it will bring severe morbidity. There is currently lack of research to explore risk factor related balance disorder in dizziness patients, especially in those who walk independently.

Aim: To investigate risk factors related balance disorder in dizziness/vertigo patients who walk independently. Read More

Klin Monbl Augenheilkd 2021 Apr 30;238(4):482-487. Epub 2021 Apr 30.

Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des aveugles, Lausanne, Switzerland.

Background: Classification and management of acquired concomitant esotropia is controversial. We sought to establish a simple clinical classification in order to determine in which cases further investigations in search of underlying pathologies are necessary.

Patients And Methods: Observational retrospective study of the files of 175 consecutive patients examined in our unit between 2009 and 2018 for acute convergent strabismus. Read More

Ugeskr Laeger 2021 04;183(15)

Dizziness and vertigo are frequent symptoms in the primary care facility and emergency departments. Episodic vestibular syndrome (EVS) is defined as episodic dizziness, vertigo or postural imbalance with remission between episodes. EVS can be divided into spontaneous (s-EVS) and triggered EVS (t-EVS). Read More

Stroke 2021 Jun 27;52(6):e224-e228. Epub 2021 Apr 27.

Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine, Biomedical Research Institute, Busan, South Korea (S.-Y.C., K.-D.C.).

Background And Purpose: The recognition of clinical features of transient vestibular symptoms (TVSs) preceding posterior circulation stroke (PCOS) would be informative to discriminate dizziness/vertigo due to vertebrobasilar transient ischemic attack from the acute transient vestibular syndrome. We sought to determine the prevalence and characteristics of TVSs preceding PCOS.

Methods: We performed a prospective multicenter observational study that had recruited 447 patients with PCOS from referral-based 4 university hospitals in Korea. Read More

J Am Acad Audiol 2021 Apr 19. Epub 2021 Apr 19.

Vestibular and Balance Program, Department of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota.

Background:  How significant asymmetries in otolith organ function in the presence of symmetrical and asymmetrical semicircular canal function influence skull vibration-induced nystagmus testing (SVINT) has not been well described.

Purpose:  The aim of the study is to examine the agreement between SVINT and caloric testing, ocular vestibular-evoked myogenic potentials (oVEMP), and cervical vestibular-evoked myogenic potentials (cVEMP) for detecting asymmetric vestibular function.

Research Design:  This is a retrospective study of patients presenting with the chief complaint of vertigo, dizziness, or imbalance. Read More

Fortschr Neurol Psychiatr 2021 May 19;89(5):211-220. Epub 2021 Apr 19.

LMU Klinikum, Neurologische Klinik und Deutsches Schwindel- und Gleichgewichtszentrum (DSGZ).

The 8 most frequent vestibular disorders account for more than 70% of all presentations of vertigo, dizziness, and imbalance. In acute (and mostly non-repetitive) vestibular disorders acute unilateral vestibulopathy and vestibular stroke are most important, in episodic vestibulopathies benign paroxysmal positional vertigo (BPPV), Menière's disease and vestibular migraine, and in chronic vestibular disorders bilateral vestibulopathy/presbyvestibulopathy, functional dizziness and cerebellar dizziness. In the last decade, internationally consented diagnostic criteria and nomenclature were established for the most frequent vestibular disorders, which can be easily applied in clinical practice. Read More

Am J Case Rep 2021 Apr 19;22:e930175. Epub 2021 Apr 19.

Neurological Department, Landstrasse Clinic, Messerli Institute, Vienna, Austria.

BACKGROUND The normalization of serum lactate levels in a patient with non-syndromic mitochondrial disorder due to the m.3243A>G mitochondrial DNA (mtDNA) variant has not been previously reported. CASE REPORT A 57-year-old woman was diagnosed with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) due to the m. Read More

J Vestib Res 2021 Apr 9. Epub 2021 Apr 9.

Department of Evaluation and Treatment of Pain, FHU INOVPAIN, CHU Timone, AP-HM, Marseille, France.

The presence of endolymphatic hydrops has been studied in many neurological disorders. The pathophysiological mechanisms may involve CSF pressure variations, transmitted to the innear ear. This hydrops could play a role in vestibular or cochlear symptoms. Read More

Exp Gerontol 2021 07 27;149:111332. Epub 2021 Mar 27.

Department of Emergency, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, No. 324 Jingwu Weiqi Road, Jinan, Shandong 250021, China; Department of Emergency, Shandong Provincial Hospital affiliated to Shandong First Medical University, No. 324 Jingwu Weiqi Road, Jinan, Shandong 250021, China. Electronic address:

Myocardial infarction (MI) is the most extensive manifestations of cardiovascular disease (CVD), associated with prolonged supply and demand blood oxygen imbalance to the heart muscle. The treatment of MI includes several conventional medicines which are beta-blockers and calcium antagonists. Though, these were reported to be either not efficient or associated with life threatening adverse effects. Read More

J Neurol Surg Rep 2021 Jan 23;82(1):e1-e5. Epub 2021 Feb 23.

Department of Radiology, Dr. Balabhai Nanavati Hospital, Mumbai, Maharashtra, India.

 A subject presenting with a unilateral sensorineural hearing loss and with vertigo/imbalance and a lesion of internal acoustic meatus (IAM) most often represents a vestibular schwannoma. Several alternative pathologies involving the region, with clinical and neuroradiological similarities, could lead to an error in judgement and management. Rare tumors of the IAM pose unique diagnostic difficulty. Read More

Otol Neurotol 2021 07;42(6):e730-e734

Hearing Sciences, Division of Clinical Neuroscience, School of Medicine, University of Nottingham.

Objective: This study investigated balance problems and vestibular function in adult cancer survivors who had completed cisplatin chemotherapy treatment.

Study Design: Observational cross-sectional study.

Setting: Tertiary care center. Read More

J Vestib Res 2021 Feb 10. Epub 2021 Feb 10.

Division of Otolaryngology, Department of Medical, Surgical and Experimental Science, University of Sassari, Italy.

Background: since the beginning of COVID-19 outbreak a growing number of symptoms and deficits associated with the new pathology have emerged, among them cochlear damage in otherwise asymptomatic COVID-19 patients has been described.

Objective: to investigate general and audiovestibular symptoms and sequelae in healed patients, and to seek for any sign of residual or permanent hearing or vestibular loss.

Methods: we reviewed the data coming from 48 Covid-19 patients whose nasopharyngeal swabs have turned negative, all employed at our facility, that opted in for a free screening of audiovestibular symptoms offered by our hospital after the aforementioned report was published. Read More

J Vestib Res 2021 Feb 3. Epub 2021 Feb 3.

Vestibular Genetics Laboratory, Boys Town National Research Hospital, Omaha, NE, USA.

Background: Otoconia-related vertigo and balance deficits are common in humans, but the molecular etiology is unknown at present.

Objective: In order to study mechanisms of otoconia formation and maintenance, we have investigated whether otoconin-90 (Oc90), the predominant otoconial constituent protein, and the NADPH oxidase Nox3, an essential regulatory protein for otoconia formation, are functionally interlinked.

Methods: We performed balance behavioral, electrophysiological, morphological and molecular cellular analyses. Read More

Laryngoscope 2021 07 27;131(7):1626-1632. Epub 2021 Jan 27.

Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, U.S.A.

Objective/hypothesis: The purpose of this review is to summarize evidence-based data regarding the ototoxic effects of potential COVID-19 therapeutics to treat patients suffering from SARS-CoV-2.

Methods: Medications under investigation as novel therapeutics to treat COVID-19 were identified using the search term coronavirus therapeutics, COVID therapeutics, and SARS-CoV-2 therapeutics on ClinicalTrials.gov and the PubMed Database. Read More

J Funct Morphol Kinesiol 2020 Mar 30;5(2). Epub 2020 Mar 30.

Medical School, University of Exeter, Exeter EX1 2LU, UK.

The vestibular system is located in the inner ear and is responsible for maintaining balance in humans. Bilateral vestibular dysfunction (BVD) is a disorder that adversely affects vestibular function. This results in symptoms such as postural imbalance and vertigo, increasing the incidence of falls and worsening quality of life. Read More

Malays J Med Sci 2020 Dec 29;27(6):89-101. Epub 2020 Dec 29.

Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.

Background: Dizziness is a common presenting complaint among patients in Malaysia. It is a vague term which could be associated with vertigo, imbalance, ataxia or syncope. In order to deal with this overwhelming complaint, a detailed history-taking is essential in confirming aetiology of disease and this should be followed by a meticulous clinical examination. Read More

J Vestib Res 2021 ;31(1):1-9

Department Of Neurology, Schlosspark-Klinik, Berlin, Germany.

This paper describes the diagnostic criteria for "Vestibular Migraine of Childhood", "probable Vestibular Migraine of Childhood" and "Recurrent Vertigo of Childhood" as put forth by the Committee for the Classification of Vestibular Disorders of the Bárány Society (ICVD) and the Migraine Classification subgroup of the International Headache Society. Migraine plays an important role in some subgroups of children with recurrent vertigo. In this classification paper a spectrum of three disorders is described in which the migraine component varies from definite to possibly absent. Read More

Brain 2021 02;144(1):128-143

Brain and Vestibular Group, Neuro-Otology Unit, Department of Brain Sciences, Charing Cross Hospital, Imperial College London, London, W6 8RF, UK.

Vestibular dysfunction, causing dizziness and imbalance, is a common yet poorly understood feature in patients with TBI. Damage to the inner ear, nerve, brainstem, cerebellum and cerebral hemispheres may all affect vestibular functioning, hence, a multi-level assessment-from reflex to perception-is required. In a previous report, postural instability was the commonest neurological feature in ambulating acute patients with TBI. Read More

Turk J Med Sci 2021 04 30;51(2):796-8001. Epub 2021 Apr 30.

Department of Otorhinolaryngology, Faculty of Medicine, Gazi University, Ankara, Turkey

Background/aims: Vestibular rehabilitation has an important role in the reduction of symptoms and in the recovery of patients in peripheral vestibular pathologies. Objective and subjective vestibular assessment tools are needed to assess vestibular rehabilitation effectiveness. The aims of the study were to develop the Turkish version of the internationally used Vestibular Rehabilitation Benefit Questionnaire (VRBQ) measure and to demonstrate the reliability and validity properties of the Turkish version in patients with peripheral vestibular hypofunction (PVH). Read More

Codas 2020 27;32(6):e20190070. Epub 2020 Nov 27.

Disciplina de Otologia e Otoneurologia, Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Universidade Federal de São Paulo/Escola Paulista de Medicina - UNIFESP/EPM - São Paulo (SP), Brasil.

Purpose: To evaluate the postural balance of type 2 diabetics with vertigo, dizziness, and/or unsteadiness.

Methods: limit of stability, pressure center displacement area, and sway velocity of 20 patients with type 2 diabetes were compared with 22 controls using the Balance Rehabilitation Unit (BRUTM, Medicaa) posturography.

Results: Compared to the control group, patients with type 2 diabetes showed a significantly lower limit of stability and a significantly higher-pressure center displacement area on a firm surface with eyes open, eyes closed, and horizontal vestibular-visual interaction; and higher sway velocity on a firm surface with eyes open and with eyes closed. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Oct;34(10):906-910

Department of Otorhinolaryngology，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan，430022，China.

To improve the level of clinical diagnosis and treatment of idiopathic bilateral vestibulopathy（IBV） by investigating the clinical characteristics of this disease. Retrospective analysis was performed on patients with IBV diagnosed, excluding patients with clear primary factors, and including IBV patients with unknown causes, to analyze their clinical symptoms and vestibular function examination results. In this group of cases, three cases were in line with the diagnosis of IBV. Read More

BMC Neurol 2020 Nov 27;20(1):430. Epub 2020 Nov 27.

Medical Statistics Group and Peninsula Clinical Trials Unit, Faculty of Health: Medicine, Dentistry and Human Science, Plymouth Science Park, 1 Davy Rd, Derriford, Plymouth, PL6 8BX, UK.

Background: Symptoms arising from vestibular system dysfunction are observed in 49-59% of people with Multiple Sclerosis (MS). Symptoms may include vertigo, dizziness and/or imbalance. These impact on functional ability, contribute to falls and significant health and social care costs. Read More

Case Rep Gastrointest Med 2020 11;2020:8842006. Epub 2020 Oct 11.

Serviço de Medicina Interna, ULSAM-Hospital de Santa Luzia, Viana Do Castelo, Portugal.

. Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors and constitute the largest group of nonepithelial digestive neoplasms. However, they do not represent more than 1% of primary digestive tumors. Read More

J Neurol 2020 Dec 8;267(Suppl 1):241-255. Epub 2020 Oct 8.

Department of Otorhinolaryngology and Head and Neck Surgery, Division of Balance Disorders, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.

Objective: To optimize the current diagnostic and treatment procedures for patients with bilateral vestibulopathy (BV), this study aimed to determine the complete spectrum of symptoms associated with BV.

Method: A prospective mixed-method study design was used. Qualitative data were collected by performing semi-structured interviews about symptoms, context, and behavior. Read More