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Dig Dis Sci 2018 Dec 3. Epub 2018 Dec 3.

Division of Colon and Rectal Surgery, Department of Surgery, The Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA, 17033-0850, USA.

Background: The management of diverticulitis is compromised by difficulty in identifying patients who require surgery for recurrent or persistent disease. Here, we introduce the concept of multifocal diverticulitis (MFD), characterized by multiple episodes of diverticulitis occurring at different locations within the colon.

Aims: To compare clinical characteristics, success of surgical management, and colonic transcriptomes of MFD patients to patients with conventional unifocal diverticulitis (UFD). Read More

Ann Med Surg (Lond) 2018 Dec 20;36:239-241. Epub 2018 Nov 20.

Caboolture Hospital, 120 McKean Street, 4510, Queensland, Australia.

Introduction: Acute appendicitis in older adults is relatively uncommon and could be the first presentation of an underlying colorectal carcinoma. Colonoscopy in these individuals affords the opportunity for earlier diagnosis and treatment. The finding of increased rates of colorectal cancer (CRC) with older patients who have had appendicitis was supported by a number of small studies and case reports in the early 1980s. Read More

Colorectal Dis 2018 Nov 29. Epub 2018 Nov 29.

Surgery department of Hospital da Luz Arrábida, Vila Nova de Gaia.

A giant colonic diverticulum (GCD) is a rare disease with less than 200 cases reported in the literature. By definition, a GCD is larger than 4cm in diameter with close sigmoid colon relationship in more than 90% of the cases. En bloc resection of the diverticulum with anterior sigmoid-rectal segment with primary anastomosis is the best treatment approach. Read More

World J Gastrointest Oncol 2018 Nov;10(11):449-464

Department of General and Laparoscopic Colorectal Surgery, Brighton and Sussex University Hospitals NHS Trust, the Royal Sussex County Hospital, Brighton, West Sussex BN2 5BE, United Kingdom.

Aim: To compare outcomes in patients undergoing rectal resection by robotic total meso-rectal excision (RTME) laparoscopic total meso-rectal excision (LTME).

Methods: Standard medical electronic databases such as PubMed, MEDLINE, EMBASE and Scopus were searched to find relevant articles. The data retrieved from all types of included published comparative trials in patients undergoing RTME LTME was analysed using the principles of meta-analysis. Read More

Nutrients 2018 Nov 28;10(12). Epub 2018 Nov 28.

Nutrition Science Solutions, LLC, Wimberley, 78676 TX, USA.

Less than 10% of most Western populations consume adequate levels of whole fruits and dietary fiber with typical intake being about half of the recommended levels. Evidence of the beneficial health effects of consuming adequate levels of whole fruits has been steadily growing, especially regarding their bioactive fiber prebiotic effects and role in improved weight control, wellness and healthy aging. The primary aim of this narrative review article is to examine the increasing number of health benefits which are associated with the adequate intake of whole fruits, especially fruit fiber, throughout the human lifecycle. Read More

Med Clin North Am 2019 Jan;103(1):101-110

Department of Internal Medicine, University of Texas Southwestern, 5323 Harry Hines Boulevard, Dallas, TX 75390-9151, USA.

Food plays an essential role in normal cellular processes; however, certain foods may also trigger or worsen certain disease states. This article focuses particularly on the role of food in common gastrointestinal and liver diseases, and discusses the current evidence that either supports or debunks common dietary recommendations. Nutrition topics discussed include the use of artificial sweetener for weight loss, avoidance of all dairy products in the setting of lactose intolerance, dietary recommendations for diverticular disease, and dietary management in cirrhotic patients with hepatic encephalopathy. Read More

Am J Case Rep 2018 Nov 22;19:1386-1392. Epub 2018 Nov 22.

Third Department of Surgery, AHEPA University Hospital, Aristotle University of Thessaloniki, School of Health Sciences, Faculty of Medicine, Thessaloniki, Greece.

BACKGROUND Although diverticular disease is well described and treated in daily clinical practice, there are cases that attract great interest because of their complexity and difficulty in management. Herein, we describe a rare case of colo-colonic fistula-complicated diverticulitis that necessitated urgent surgical intervention. CASE REPORT A 76-year-old female patient with a known history of diverticular disease of the sigmoid colon presented in the Emergency Department for evaluation of left lower quadrant abdominal pain. Read More

Arthritis Res Ther 2018 Nov 20;20(1):258. Epub 2018 Nov 20.

Arthritis Research UK Primary Care Centre, Primary Care Sciences, Keele University, Keele, ST5 5BG, UK.

Background And Aim: Comorbidities are known to exist in many rheumatological conditions. Polymyalgia rheumatica (PMR) is a common inflammatory rheumatological condition affecting older people which, prior to effective treatment, causes severe disability. Our understanding of associated comorbidities in PMR is based only on case reports or series and small cohort studies. Read More

Clin Gastroenterol Hepatol 2018 Dec;16(12):2001-2002

Gastroenterology Service, Azienda Sanitaria Locale Barletta-Andria-Trani, Andria, Italy; Clinical Pharmacology and Digestive Pathophysiology Unit, Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy.

Endoscopy 2018 Nov 19. Epub 2018 Nov 19.

Division of Gastroenterology and Hepatology, Johns Hopkins Medical Institution, Baltimore, Maryland, USA.

Background:  The aim of this study is to report a novel, multicenter experience with the diverticular peroral endoscopic myotomy (D-POEM) technique in the management of esophageal diverticula.

Methods:  This is a multicenter, international, retrospective study involving three centers. D-POEM was performed using the principles of submucosal endoscopy. Read More

Dig Endosc 2018 Nov 18. Epub 2018 Nov 18.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nihon University School of Medicine, 1-6, Kanda-Surugadai, Chiyoda-ku, 101-8309, Tokyo, Japan.

Endoscopic submucosal dissection (ESD) is standard treatment for early esophageal cancer (EEC). Cancer located within the diverticulum, which has a thin or nonexistent muscular coating, is extremely rare. We describe successful ESD of esophageal diverticular cancer with a high risk of perforation. Read More

Crit Care Clin 2019 Jan 25;35(1):169-186. Epub 2018 Oct 25.

Department of Critical Care Medicine, Mayo Clinic Arizona, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA.

Despite improvements in overall graft function and patient survival rates after solid organ transplantation, complications can lead to significant morbidity and mortality. Cardiovascular complications include heart failure, arrhythmias leading to sudden death, hypertension, left ventricular hypertrophy, and allograft vasculopathy in heart transplantation. Neurologic complications include stroke, posterior reversible encephalopathy syndrome, infections, neuromuscular disease, seizure disorders, and neoplastic disease. Read More

G Chir 2018 Sep-Oct;34(5):319-322

Acute diverticulitis typically occurs in patients over 80 years old. The last five years we observed an increased incidence of acute diverticulitis in patients under 50 years. The aim of this study is to evaluate the increased rate of patients under 50 years that are hospitalized due to acute diverticulitis. Read More

World J Clin Oncol 2018 Oct;9(6):119-122

Division of Digestive Surgery, University Hospitals of Geneva, Genève 1211, Switzerland.

Colorectal cancer constitutes an important burden on the healthcare system. Screening at-risk populations to reduce colorectal cancer-related morbidity and mortality has become part of good clinical practice. However, recommendations regarding subgroups of patients with diverticular disease are subject to controversy. Read More

BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.

General Surgery, Royal Sussex County Hospital, Brighton, UK.

Intussusception is the invagination of a proximal segment of bowel into the lumen of an adjacent distal segment. It is a common condition in the paediatric age group although it rarely occurs in adults. Organic lesions in the bowel wall are the primary cause of adult intussusceptions with malignant neoplasms being the most common. Read More

Neurourol Urodyn 2018 Nov 9. Epub 2018 Nov 9.

Department of Urology, University College London Hospitals NHS Foundation Trust at Westmoreland Street, Marylebone, London.

Aims: The complexity of urethral diverticulectomy depends on location, size, and degree of circumferential involvement. MRI features were examined to predict functional outcome after surgery for urethral diverticulum (UD).

Methods: A prospectively acquired database was of all patients who have had surgical excision of UD at a tertiary center since 2004 was reviewed. Read More

J Gastrointest Surg 2018 Nov 8. Epub 2018 Nov 8.

Department of Surgery, Indiana University School of Medicine, Indianapolis, USA.

Background: Colovesical fistula (CVF) is an uncommon complication of diverticulitis. Substantial heterogeneity exists in the perioperative management of this condition. We seek to evaluate the role of bladder leak testing, closed suction drainage, prolonged bladder catheter usage, and routine postoperative cystogram in the management of CVF. Read More

Medicine (Baltimore) 2018 Nov;97(45):e13176

Department and Clinic of Gastrointestinal and General Surgery, Medical University, Wroclaw. Poland.

Rationale: Retroperitoneal colonic perforation is a rare cause of retroperitoneal abscess. It presents, more frequently in frail elderly patients, with heterogeneous signs and symptoms which hamper the clinical diagnosis. Subcutaneous emphysema with pneumomediastinum and iliopsoas muscle abscess are unusual signs. Read More

Curr Opin Gastroenterol 2019 Jan;35(1):27-33

Division of Gastroenterology and Hepatology, Lynda K and David M Underwood Center for Digestive Disorders, Houston Methodist Hospital and Weill Cornell Medical College, Houston, Texas, USA.

Purpose Of Review: Irritable bowel syndrome (IBS) is a common symptomatic disorder in the Western world and colonic diverticula are also prevalent; however, relationships between IBS-type symptoms and diverticula have been a source of much debate. Our goal was to reassess these relationships in the light of new data.

Recent Findings: On removing from consideration clinical scenarios which are directly related to diverticula (i. Read More

Surg Endosc 2018 Nov 7. Epub 2018 Nov 7.

Department of General e Surgery, Ospedale Citta Sesto San Giovanni, ASST Milano Nord, Sesto San Giovanni, Italy.

Background: Recently, minimally invasive treatment of complicated sigmoid diverticulitis is becoming a valid alternative to standard procedures. Robotic approach may be useful to allow more precise dissection in arduous pelvic dissection as in complicated diverticulitis. The aim of this study is to investigate effectiveness, potential benefits and short-term outcomes of robotic-assisted laparoscopic surgical resection, compared with fully laparoscopic resection in complicated diverticulitis. Read More

J Wound Ostomy Continence Nurs 2018 Nov/Dec;45(6):510-515

Mohammed Iyoob Mohammed Ilyas, MBBS, MS, MRCS, University of Arizona College of Medicine, Tucson, and Southern Arizona Veterans Affairs Health Care System, Tucson. David A. Haggstrom, MD, Richard L. Roudebush Veterans Affairs Medical Center, and Indiana University School of Medicine, Indianapolis. Melinda A. Maggard-Gibbons, MD, MSHS, Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California. Christopher S. Wendel, MS, University of Arizona College of Medicine, Tucson, and Southern Arizona Veterans Affairs Health Care System, Tucson. Susan Rawl, PhD, RN, Indiana University School of Nursing, Indianapolis. Christian Max Schmidt, MD, PhD, MBA, Richard L. Roudebush Veterans Affairs Medical Center, and Indiana University School of Medicine, Indianapolis. Clifford Y. Ko, MD, UCLA School of Medicine, Los Angeles, California. Robert S. Krouse, MD, Corporal Michael J. Crescenz Veterans Affairs Medical Center, and University of Pennsylvania Department of Surgery, and Leonard Davis Institute of Health Economics, Philadelphia, Pennsylvania.

Purpose: The purpose of this study was to describe clinical outcomes of patients with temporary ostomies in 3 Veterans Health Administration hospitals.

Design: Retrospective descriptive study, secondary analysis.

Sample And Setting: Veterans with temporary ostomies from 3 Veterans Health Administration hospitals who were enrolled in a previous study. Read More

Ann Gastroenterol 2018 Nov-Dec;31(6):747-749. Epub 2018 Sep 26.

Gastroenterology and Digestive Endoscopy, Nuovo Regina Margherita Hospital, Rome, Italy.

The pathogenetic process of acute diverticulitis remains speculative. According to the most widely accepted theory, the mechanism involved is "traumatic" damage to the mucosa due to fecolith impaction, as occurs in large diverticula. However, not uncommonly, diverticulitis develops in young patients with only few and small diverticula, where fecolith trapping is very unlikely. Read More

G Chir 2018 Sep-Oct;39(5):319-322

Acute diverticulitis typically occurs in patients over 80 years old. The last five years we observed an increased incidence of acute diverticulitis in patients under 50 years. The aim of this study is to evaluate the increased rate of patients under 50 years that are hospitalized due to acute diverticulitis. Read More

Int J Surg Case Rep 2018 4;52:114-116. Epub 2018 Oct 4.

Division of General Surgery, Department of Surgery, Tri-Services General Hospital, National Defense Medical Center, No.325, Sec.2, Chenggong Rd., Neihu District, Taipei City 114, Taiwan. Electronic address:

Introduction: Ingestion of a foreign body rarely results in perforation of the gastrointestinal tract. Foreign bodies such as dentures, fish bones, chicken bones, toothpicks and cocktail sticks have been known to cause bowel perforation; however, bowel perforation caused by shrimp leg has not been reported so far.

Presentation Of Case: We report a case of a 69-years-old man who presented with a 4-months epigastric pain. Read More

Br J Surg 2018 Oct 18. Epub 2018 Oct 18.

Surgical Health Outcomes and Research Enterprise (SHORE), Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA.

Background: Studies examining long-term outcomes following resolution of an acute diverticular abscess have been limited to single-institution chart reviews. This observational cohort study compared outcomes between elective colectomy and non-operative management following admission for an initial acute diverticular abscess.

Methods: The Statewide Planning and Research Cooperative System was queried for unscheduled admissions for an initial acute diverticular abscess in 2002-2010. Read More

Intern Med 2018 Oct 17. Epub 2018 Oct 17.

Departments of Internal Medicine, Saga Medical School, Japan.

Objective This historical control study was performed to evaluate i) the rebleeding rate of bleeding colon diverticula treated with endoscopic band ligation (EBL) versus endoscopic clipping (EC) and ii) risk factors for rebleeding of diverticula initially treated by endoscopic hemostasis. Methods From January 2010 to December 2012, 68 patients were treated with EC, and from January 2013 to August 2016, 67 patients were treated with EBL. All patients in each group were followed up for one year to check for rebleeding. Read More

Can J Gastroenterol Hepatol 2018 16;2018:5437135. Epub 2018 Sep 16.

Diaverum Medical Scientific Office, Lund, Sweden.

Background: Diverticular disease treatment is limited to fibres, antibiotics, and surgery. There is conflicting evidence on mesalazine benefits and harms.

Aim: We systematically reviewed current evidence on benefits and harms of mesalazine versus all other treatments in people with diverticular disease. Read More

ANZ J Surg 2018 Oct 10. Epub 2018 Oct 10.

Department of Colorectal Surgery, Singapore General Hospital, Singapore.

Background: Although most diverticular bleeding resolve spontaneously, up to 30% can bleed torrentially, necessitating angioembolization, endoscopic or surgical intervention. Non-contact endoscopic therapies, such as topical haemostatic powders, do not require precise targeting and are attractive because identification of specific culprit diverticulum is difficult. While their use in non-variceal upper gastrointestinal bleeding is well established, its role in lower gastrointestinal bleeding remains unclear. Read More

Clin Gastroenterol Hepatol 2018 Oct 6. Epub 2018 Oct 6.

Section of Gastroenterology, Hepatology, and Nutrition, University of Chicago Medical Center, Chicago, Illinois. Electronic address:

Background & Aims: Colonoscopy within 24 hours (early colonoscopy) is recommended for patients with colonic diverticular bleeding, but it is unclear if this strategy improves postdischarge outcomes. We aimed to determine whether early colonoscopy is associated with decreased risk of rebleeding and hospital re-admission within 30 days.

Methods: We performed a retrospective cohort study using Marketscan (Truven Health Analytics, Inc, Ann Arbor, MI), a nationwide insurance claims database. Read More

Minerva Gastroenterol Dietol 2018 Oct 2. Epub 2018 Oct 2.

Gastroenterology Service, ASL BAT, Andria, Barletta-Andria-Trani, Italy -

The incidence of diverticulosis and diverticular disease of the colon is increasing worldwide. Although the majority of patients remains asymptomatic long-life, the prevalence of diverticular disease of the colon, including acute diverticulitis, is substantial and is becoming a significant burden on National Health Systems in terms of direct and indirect costs. Fiber, non-absorbable antibiotics and probiotics seem to be effective in treating symptomatic and uncomplicated patients, and 5-aminosalicylic acid might help prevent acute diverticulitis. Read More

Curr Opin Pharmacol 2018 Oct 3;43:124-131. Epub 2018 Oct 3.

Medical-Surgical Department of Clinical Sciences and Translational Medicine, University Hospital Sant'Andrea, University Sapienza, Rome, Italy.

Diverticular disease (DD) is a highly prevalent disease in western industrialized countries that encompasses a complex set of disorders. Because of its complexity and heterogeneity, both from a pathogenic and a clinical point of view, the management of this disease represent a challenge in clinical practice. This review aims to analyze and summarize the most recent evidence on the medical strategies for DD, considering separately the different stages of the disease, from prevention of diverticula formation to treatment of acute diverticulitis and prevention of recurrences. Read More

United European Gastroenterol J 2018 Oct 30;6(8):1169-1178. Epub 2018 Sep 30.

Department of Internal Medicine, Institute of Digestive Diseases and Nutrition, Korea University College of Medicine, Seoul, Korea.

Background: Whether the etiology of potential small-bowel bleeding depends on the age and gender of the patient is not yet fully understood.

Methods: A total of 1953 patients who underwent video capsule endoscopy (VCE) to evaluate potential small-bowel bleeding and were registered in the Capsule Endoscopy Nationwide Database Registry from 2003 to 2014 were eligible for this study. VCE findings and the etiology of small-bowel bleeding were analyzed by age and gender. Read More

ACG Case Rep J 2018 26;5:e71. Epub 2018 Sep 26.

Department of Abdominal Surgery, Isala Hospital, Zwolle, Netherlands.

Diverticula of the colon are the most common cause of lower gastrointestinal bleeding in adults. In cases of persistent loss of blood or severe acute hemorrhage, treatment is required. However, if these modern intervention techniques are inadequate, surgical resection of the colon may be required. Read More

Auton Neurosci 2018 Sep 18. Epub 2018 Sep 18.

Institute of Anatomy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address:

Diverticular disease (DD) is one of the most prevalent diseases of the large bowel. Lately, imbalance of neuro-muscular transmission has been recognized as a major etiological factor for DD. Neuronal calcitonin gene-related peptide (CGRP) is a potent gastrointestinal smooth muscle relaxant shown to have a widespread effect within the alimentary tract. Read More

Scand J Gastroenterol 2018 Sep 28:1-8. Epub 2018 Sep 28.

a Department of Clinical Medicine , UiT The Arctic University of Norway , Tromsø , Norway.

Objective: To investigate the use of specialized health care services for diverticular disease in different hospital referral regions in Norway.

Materials And Methods: Nationwide cross-sectional study with data from the Norwegian Patient Registry and Statistics Norway. All Norwegian inhabitants aged 40 years and older in the years 2012-16 (2,517,938) were included. Read More

J Gastrointest Surg 2018 Sep 24. Epub 2018 Sep 24.

Division of Surgery, Section of Colon and Rectal Surgery, Albany Medical Center, 47 New Scotland Avenue, MC-61, Albany, NY, 12208, USA.

Background: The purpose of this study was to review our experience with laparoscopic colectomy and fistula resection, evaluate the frequency of conversion to open, and to compare the perioperative courses of the complete laparoscopic and conversion groups.

Methods: This study is a retrospective analysis of 111 consecutive adult patients with diverticular fistulae diagnosed clinically or radiographically over 11 years at a single institution. Five patients were excluded for preoperative comorbidities. Read More

Ann Surg 2018 Sep 20. Epub 2018 Sep 20.

Department of Surgery, Jeroen Bosch Hospital, Hertogenbosch, The Netherlands.

Objective: The aim of this study was to establish whether surgical or conservative treatment leads to a higher quality of life (QoL) in patients with recurring diverticulitis and/or ongoing complaints.

Summary Of Background Data: The 6 months' results of the DIRECT trial, a randomized trial comparing elective sigmoidectomy with conservative management in patients with recurring diverticulitis (>2 episodes within 2 years) and/or ongoing complaints (>3 months) after an episode of diverticulitis, demonstrated a significantly higher QoL after elective sigmoidectomy. The aim of the present study was to evaluate QoL at 5-year follow-up. Read More

J Visc Surg 2018 Sep 18. Epub 2018 Sep 18.

Department of Surgery, Colorectal Unit, Michallon University Hospital, 38000 Grenoble, France; University Grenoble Alps, UMR 5525, CNRS, TIMC-IMAG, 38000 Grenoble, France.

J Gastrointestin Liver Dis 2018 Sep;27(3):291-297

Gastroenterology Service, ASL BAT, Andria (BT),

Background And Aims: Symptomatic Uncomplicated Diverticular disease (SUDD) affects about 25% of patients harboring colonic diverticula. We assessed the effectiveness of mesalazine in improving symptoms (namely abdominal pain, primary outcome) and in preventing diverticulitis occurrence (secondary outcome) in patients with SUDD.

Methods: Pertinent studies were selected from the Medline and the Cochrane Central Register of Controlled Trials. Read More

J Gastrointestin Liver Dis 2018 Sep;27(3):227-231

Prof. Octavian Fodor Regional Institute of Gastroenterology and Hepatology ;Gastroenterology and Hepatology Medical Center;Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Background And Aims: The aim of this study is to present the experience of our center over the last 8 years in a series of patients with Zenker's diverticulum (ZD), treated using an endoscopic, minimally invasive procedure.

Methods: We retrospectively included 31 patients with a previously established diagnosis of ZD based on endoscopic and oral contrast examinations. Patients' age, comorbidities, size of the diverticulum or previous endoscopic treatment were not considered exclusion criteria. Read More

Open Heart 2018 27;5(2):e000855. Epub 2018 Aug 27.

Department of Cardiothoracic Surgery, Heart Centre, American Hospital Dubai, Dubai, United Arab Emirates.

Objectives: The aim of this retrospective series is to describe the prevalence and clinical significance of the incidental findings found during pre-transcatheter aortic valve implantation (TAVI) work-up and to ascertain the clinical course of such patients.

Methods: Consecutive patients undergoing TAVI from 2013 to 2015 where a TAVI CT assessment was performed (n=138) were included in the study. All incidental findings that were not expected from the patient's history were discussed at the TAVI multidisciplinary meeting in order to ascertain the clinical significance of said findings and whether they would alter the proposed course of treatment. Read More

Vnitr Lek 2018 ;64(6):621-634

Diverticular disease is one of the most common gastroenterological diseases. Its morphological basis are diverticula, whose prevalence in adults nears 50 %, with 25% clinical symptomatology and 5% occurrence of complications. It is a disease of older age, however its incidence is also rising in younger individuals, where it takes a more severe course. Read More

Tech Coloproctol 2018 09 15;22(9):657-662. Epub 2018 Sep 15.

Colon and Rectal Surgery Division, Humanitas Clinical and Research Center, Via Alessandro Manzoni, 56, 20089, Rozzano, Milan, Italy.

Background: Laparoscopic sigmoidectomy is the gold standard for elective surgical treatment of diverticulitis. A periumbilical single-port technique reduces the size of the access wound, usually to 3-4 cm. However, in the presence of large phlegmon or fistulae, the risk of conversion is higher and the extraction site might be enlarged. Read More

Digestion 2018 Sep 14:1-8. Epub 2018 Sep 14.

Department of Gastroenterology, Toyonaka Municipal Hospital, Osaka, Japan.

Background/aims: It is unclear why colonic diverticular bleeding and diverticulitis rarely coexist. This study compared the characteristics of these conditions.

Methods: This single-center retrospective study examined 310 consecutive patients hospitalized with an episode of diverticular disease (cases) and outpatients without a diverticular episode (controls) from January 2012 to December 2015. Read More

Surg Infect (Larchmt) 2018 Oct 11;19(7):648-654. Epub 2018 Sep 11.

5 Department of Surgery, John Peter Smith Health Network , Fort Worth, Texas.

Background: Acute diverticulitis occurs in 25% of individuals with diverticular disease and is associated with significant morbidity and mortality rates. Disease severity is classified as uncomplicated or complicated, with the latter including perforation, fistula, obstruction, or distant abscess. Uncomplicated diverticulitis often improves without surgery or invasive therapies. Read More

Tech Coloproctol 2018 08 8;22(8):597-604. Epub 2018 Sep 8.

Italian Group of Diverticular Disease (GRIMAD), Rome, Italy.

Background: Epidemiological studies in Western countries have documented an increase of hospitalizations for acute diverticulitis (AD) but Italian evidence is scarce. The aim of the present study was to analyse the trend in hospitalization for AD, including in-hospital mortality, in Italy from 2008 to 2015.

Methods: Through the Italian Hospital Information System of the National Health System, we identified diverticulitis of the colon as a discharge diagnosis. Read More

Nat Genet 2018 Oct 3;50(10):1359-1365. Epub 2018 Sep 3.

Department of Internal Medicine, Division of Gastroenterology, Ann Arbor, MI, USA.

Diverticular disease is common and has a high morbidity. Treatments are limited owing to the poor understanding of its pathophysiology. Here, to elucidate its etiology, we performed a genome-wide association study of diverticular disease (27,444 cases; 382,284 controls) from the UK Biobank and tested for replication in the Michigan Genomics Initiative (2,572 cases; 28,649 controls). Read More

Ann Surg 2018 Aug 30. Epub 2018 Aug 30.

Department of Surgery, Mayo Clinic, Rochester, MN.

Objective: To determine the relative or combined effects of Crohn disease (CD) and ulcerative colitis (UC) and the operation performed on postoperative venous thromboembolism (VTE) to better guide recommendations on extended VTE prophylaxis.

Summary Background Data: There is growing evidence to suggest patients with inflammatory bowel disease have an increased risk of postoperative VTE, but prior studies have not accounted for the operation performed nor acknowledged differences between CD and UC.

Methods: The American College of Surgeons National Surgical Quality Improvement Project database from 2005 to 2016 was queried for patients with a diagnosis of CD, UC, malignancy, or benign disease (diverticular disease, Clostridium difficile) undergoing major abdominal surgery. Read More

Case Rep Surg 2018 7;2018:6197828. Epub 2018 Aug 7.

Department of Surgery, Harlem Hospital Center, Columbia University, New York, NY, USA.

Introduction: Duodenal diverticulum is a rare disease that can be easily missed. The incidence of duodenal diverticulum diagnosed by upper GI study is approximately 5%. Autopsy results show that 22% of the population have duodenum diverticulum. Read More

Case Rep Surg 2018 31;2018:3030869. Epub 2018 Jul 31.

Hôpital Fribourgeois Riaz, Rue de l'Hôpital 9, Case Postale 70, Riaz, 1632 Fribourg, Switzerland.

The onset of colon diverticular disease is a frequent event, with a prevalence that increases with age. Amongst possible complications, free peritoneal perforation with abscess formation may occur. We herein describe two rare presentations of an extraperitoneal sigmoid diverticulum perforation. Read More