Search Our Scientific Publications & Authors

Acta Biomed 2021 Apr 30;92(S1):e2021090. Epub 2021 Apr 30.

UOC Neurologia, Department of Systems Medicine, University of Tor Vergata.

Efficacy, safety and tolerability of lacosamide in the treatment of status epilepticus are well described. However, other evidence of its pharmacologic profile in elderly patients with other comorbidities seems warranted. We describe the case of an 80 year-old woman with an history of arterial hypertension, ischemic cardiomyopathy, COPD, CKD, previous laryngeal cancer, a stoma positioning for diverticular disease and previous surgery for a left frontal meningioma. Read More

Int J Colorectal Dis 2021 May 3. Epub 2021 May 3.

Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany.

Background: Diverticular disease represents a gastrointestinal disorder of high prevalence in developed countries that often leads to psychological distress. Here, we aimed at evaluating a potential association between diverticular disease and depression or anxiety disorders in outpatients in Germany.

Methods: Using the Disease Analyzer database featuring data of over 8 million patients treated in German general practices, we identified 61. Read More

J Anus Rectum Colon 2021 28;5(2):148-157. Epub 2021 Apr 28.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, St Marianna University School of Medicine, Kanagawa, Japan.

Objectives: This study aimed to examine the clinical characteristics of colonic diverticular bleeding (CDB) in elderly individuals.

Methods: This retrospective case-control study was conducted at a single tertiary center. A total of 519 patients (356 men and 163 women; mean age of 73. Read More

Front Med (Lausanne) 2021 14;8:655113. Epub 2021 Apr 14.

Pathology Unit, Department of Surgical and Diagnostic Sciences (DISC), University of Genoa, Genoa, Italy.

Seeds may be found in gastrointestinal tissue samples, and their multifaceted appearance may be challenging. The aim is to report a rough incidence of pathology samples which show seeds, specify the most frequent sample types and show an iconography of the most commonly identified seeds. Between 2017 and 2020, all gastrointestinal pathology cases in which seeds/seed parts were found, were collected and seed type described by referencing a seed image library. Read More

Clin Res Hepatol Gastroenterol 2021 Apr 27:101711. Epub 2021 Apr 27.

Gastroenterology and Endoscopy Units, Fondazione "Casa Sollievo della Sofferenza", IRCCS, San Giovanni Rotondo, Italy. Electronic address:

Inverted colonic diverticulum (ICD) is a rare intraluminal lesion occurring in about 0.7-1.7% of people, often endoscopically indistinguishable from polyps. Read More

J Pers Med 2021 Apr 14;11(4). Epub 2021 Apr 14.

Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 1-00168 Rome, Italy.

How can the knowledge of probiotics and their mechanisms of action be translated into clinical practice when treating patients with diverticular disease and acute diverticulitis? Changes in microbiota composition have been observed in patients who were developing acute diverticulitis, with a reduction of taxa with anti-inflammatory activity, such as Clostridium cluster IV, Lactobacilli and Bacteroides. Recent observations supported that a dysbiosis characterised by decreased presence of anti-inflammatory bacterial species might be linked to mucosal inflammation, and a vicious cycle results from a mucosal inflammation driving dysbiosis at the same time. An alteration in gut microbiota can lead to an altered activation of nerve fibres, and subsequent neuronal and muscular dysfunction, thus favoring abdominal symptoms' development. Read More

Nutrients 2021 Apr 14;13(4). Epub 2021 Apr 14.

Medical-Surgical Department of Clinical Sciences and Translational Medicine, University Sapienza, 00189 Rome, Italy.

Recent evidence showed that dietary habits play a role as risk factors for the development of diverticular complications. This systematic review aims to assess the effect of dietary habits in the prevention of diverticula complications (i.e. Read More

Medicina (Kaunas) 2021 Apr 8;57(4). Epub 2021 Apr 8.

Department of Public Health, University of Naples "Federico II", Via S. Pansini, 5, 80131 Naples, Italy.

The role of physical activity (PA) in elderly patients admitted to surgical units for mild acute diverticulitis in the development of disability has not been clarified so far. Our aim is to demonstrate the relationship between physical activity and better post-discharge outcomes on disability in elderly population affected by diverticular disease. We retrospectively reviewed data of 56 patients (32 Males-24 females) collected from October 2018 and March 2020 at Cardarelli Hospital in Campobasso. Read More

Colorectal Dis 2021 Apr 29. Epub 2021 Apr 29.

Aim: Diverticular disease is an increasingly common problem in western society with a variety of treatment options for those presenting with acute diverticulitis, dependent on clinical presentation. Additionally, there is significant international variability in the index management, and few published data on real-world clinical practice. The aim of DAMASCUS is to identify areas of practice variability and their potential association with differences in short- and medium-term clinical outcomes. Read More

Cesk Patol 2021 ;57(1):44-48

In this paper, we report autopsy findings of a 1-day old full-term mature female neonate with pulmonary hypoplasia diagnosed postnatally. Death was attributed to acute respiratory failure due to hyaline membrane disease. We describe pathological features of calcified Meckels diverticulum with osseous metaplasia and inflammatory changes in adjacent peritoneum. Read More

Rozhl Chir 2021 ;100(2):94-96

Authors present a case of a 58-year old pacient that underwent acute surgery for perforation of descending colon diverticulum by swallowed rabbit bone. The thesis focuses only on foreign bodies swallowed by adult patients. Comprehensive spectrum of foreign bodies that have entered the digestive tract in another way is omitted. Read More

Eur Surg Res 2021 Apr 27:1-7. Epub 2021 Apr 27.

General and Visceral Surgery, University Hospital Basel, Basel, Switzerland.

Introduction: Anastomotic leakage (AL) in colorectal surgery occurs with an incidence of up to 20%. Bowel perfusion is deemed to be one of the most important factors for anastomotic healing. However, not much is known about its variability during colorectal surgery and its impact on the outcome. Read More

Medwave 2021 Mar 26;21(2):e8140. Epub 2021 Mar 26.

Departamento de Cirugía, Escuela de Medicina, Universidad Finis Terrae, Santiago, Chile. ORCID: 0000-0002-9947-0728.

Introduction: Acute diverticulitis is one of the complications of diverticular disease. Nowadays, there is a paradigm shift regarding the use of antibiotics to manage acute uncomplicated diverticulitis in hospitalized patients, with controversial information about it.

Methods: A search was done in Epistemonikos, the most comprehensive health-related systematic review database, maintained by screening multiple information sources including MEDLINE/PubMed, EMBASE, Cochrane, among others. Read More

Chirurg 2021 Apr 26. Epub 2021 Apr 26.

Chirurgische Klinik, Universitätsmedizin Mannheim, Medizinische Fakultät, Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.

Background: There are various procedures to be considered in the surgical treatment of complicated diverticulitis, which must be selected depending on the classification of diverticular disease (CDD) type and the condition of the patient.

Objective: Comparison of surgical procedures with respect to aspects such as morbidity, mortality, reconstructive surgery and postoperative quality of life.

Material And Methods: Evaluation, analysis and assessment of the current literature on surgical treatment of diverticular disease. Read More

BJS Open 2021 Mar;5(2)

National Institute for Health Research Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Background: The management of perforated diverticular disease has changed in the past 10 years with a move towards less surgical intervention. This population-based cohort study aimed to define the risk of death and readmission following non-operative management of perforated diverticular disease.

Methods: Patients diagnosed with perforated diverticular disease and managed without surgery were identified from the linked Clinical Practice Research Datalink and Hospital Episode Statistics data from 2000 to 2013. Read More

World J Clin Cases 2021 Apr;9(11):2446-2457

Hitachi Medical Education and Research Center, University of Tsukuba, Ibaraki 317-0077, Japan.

Background: Colonoscopy within 24 h of hospital admission for colonic diverticular bleeding (CDB) is recommended. However, little is known about rates of rebleeding within 30 d. We posited that a group of patients who underwent contrast-enhanced computed tomography (CT) within 4 h of the last hematochezia and colonoscopy within 24 h would experience fewer incidences of rebleeding. Read More

Chirurg 2021 Apr 22. Epub 2021 Apr 22.

Klinik für Radiologie, Städtisches Klinikum St. Georg Leipzig, Delitzscher Str. 141, 04129, Leipzig, Deutschland.

Background: Diverticular disease frequently leads to emergency admissions. Clinical parameters are not sufficiently accurate to determine the extent of acute colonic diverticulitis, thus a quick, reproducible and valid diagnostic imaging procedure is required.

Objective: In the following, the imaging methods commonly used for the diagnostic work-up and staging of diverticulitis are presented and classified in the context of the data situation and clinical reality. Read More

Ulus Travma Acil Cerrahi Derg 2021 May;27(3):325-330

Department of General Surgery, KTO Karatay University Faculty of Medicine, Konya-Turkey.

Background: The optimum biochemical or hematological marker to determine diagnosis and severity of acute diverticulitis has not been established. We aimed to compare the utility of hematological parameters in the diagnosis and severity of acute diverticulitis.

Methods: Sixty-nine patients in diverticular disease (acute diverticulitis and diverticulosis subgroups) and 36 patients in control group were included in the study. Read More

Esophagus 2021 Apr 20. Epub 2021 Apr 20.

Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.

The traditional way to tackle Zenker's diverticulum (ZD) has been flexible endoscopic septum division (FESD). Recently, the concept of per oral endoscopic myotomy has been found useful for managing diverticular diseases of the esophagus and has been termed DPOEM. We performed a systematic review and meta-analysis to evaluate the efficacy and safety of D-POEM in diverticular disease of the esophagus and to compare it with FESD. Read More

Eur J Gastroenterol Hepatol 2021 Apr 16. Epub 2021 Apr 16.

Territorial Gastroenterology Service, ASL BAT, Andria (BT) Department of Medical and Surgical Sciences, Post-graduate School of Digestive Diseases, Catholic University Division of Gastroenterology, 'S. Camillo' Hospital, Rome Digestive Endoscopy Unit, AULSS7 'Pedemontana', Santorso (VI) Division of Surgery, 'P. Colombo' Hospital, ASL RM6, Velletri (Rome) Department of Medicine and Surgery, University of Parma, Parma Division of Internal Medicine and Gastroenterology, 'Cristo Re' Hospital, Rome, Italy.

Aim: The real prevalence of symptomatic uncomplicated diverticular disease (SUDD) is still unknown. The aim of this study was to assess the prevalence of SUDD, post-diverticulitis SUDD (PD-SUDD) and irritable bowel syndrome (IBS)-like symptoms in a real-life population.

Methods: A cohort of patients, submitted to colonoscopy from 1st January 2012 to 30th April 2018 was revised. Read More

Dermatol Online J 2021 Mar 15;27(3). Epub 2021 Mar 15.

Department of Dermatology, Hospital Clínico Universitario Lozano Blesa, Zaragoza.

Pyoderma gangrenosum is characteristically associated with inflammatory bowel disease. However, the association between this neutrophilic dermatosis and diverticular disease is scarcely mentioned in the literature. Diverticulitis should be included in the differential diagnosis in patients with pyoderma gangrenosum and gastrointestinal complaints, or even in asymptomatic patients, particularly in the elderly. Read More

Chirurg 2021 Apr 14. Epub 2021 Apr 14.

Medizinische Fakultät, Universität Köln, Köln, Deutschland.

Diverticula of the colon are very common and usually asymptomatic but 20% of people with diverticulosis develop symptoms and sometimes also complications, such as diverticulitis with abscesses or perforation and bleeding. In the long-term stenoses or a conglomerate can occur. The treatment depends on the type of diverticular disease, on the knowledge of risk indicators and imaging with sonography or computed tomography (CT). Read More

Ann R Coll Surg Engl 2021 Apr 14. Epub 2021 Apr 14.

Cambridge University Hospitals NHS Foundation Trust, UK.

Introduction: Diverticular disease is one of the most frequent reasons for attending emergency departments and surgical causes of hospital admission. In the past decade, many surgical and gastroenterological societies have published guidelines for the management of diverticular disease. The aim of the present study was to appraise the methodological quality of these guidelines using the Appraisal of Guidelines Research and Evaluation II (AGREE II) tool. Read More

Gerontology 2021 Apr 13:1-9. Epub 2021 Apr 13.

Department of Internal Medicine, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia, Italy.

Introduction: The Multidimensional Prognostic Index (MPI) is a validated tool for assessing mortality risk in hospitalised patients. We aimed to evaluate whether the MPI predicted mortality and the risk of developing diverticular disease (DD) complications in older patients.

Methods: This is a multicentre study conducted in January 2016-March 2018. Read More

ANZ J Surg 2021 04;91(4):761-762

Department of Colorectal Surgery, Garg Fistula Research Institute, Panchkula, India.

Rom J Morphol Embryol 2020 Jul-Sep;61(3):841-851

Department of Medical and Surgical Sciences, University of Cantabria, Santander, Spain;

Abdominal elastotic deposits are uncommon lesions that often presents as polyps. They show three histological patterns: fibroelastosis, angioelastosis, and elastofibroma. We describe 23 cases including rare locations, such as mesentery, greater omentum, hernia sac, spleen, peripancreatic fat, and hypodermal fat. Read More

J Clin Med 2021 Mar 12;10(6). Epub 2021 Mar 12.

Gastroenterology Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

Ulcerative colitis (UC) and colonic diverticulosis can co-exist in some patients. However, the natural history of UC associated with colonic diverticulosis is not well known. We here compared the disease characteristics and outcome of UC patients with and without concomitant colonic diverticulosis. Read More

Br J Hosp Med (Lond) 2021 Mar 13;82(3):1-6. Epub 2021 Mar 13.

Institute of Public Health, University of Cambridge, Cambridge, UK.

Antibiotics are one of the most widely used classes of drugs within hospitals in the UK. They have a wide range of uses within all surgical specialties, both as preoperative prophylaxis and for treatment of acute surgical conditions. Antimicrobial resistance has increasingly been seen as a major issue, as the production of new antibiotics has decreased and overall use worldwide has increased. Read More

Dig Surg 2021 Mar 30:1-7. Epub 2021 Mar 30.

Department of General Surgery, Mayo University Hospital, Mayo, Castlebar, Ireland.

Background: Mural thickening (MT) on computed tomography (CT) poses a diagnostic dilemma in the absence of clear reporting guidelines. The aim of this study was to analyse CT reports, identifying patients in whom gastrointestinal wall MT was observed, and to correlate these reports with subsequent endoscopic evaluation.

Methods: Patients with MT who had follow-up endoscopy were included in the study (n = 308). Read More

Endoscopy 2021 04 29;53(4):456. Epub 2021 Mar 29.

Division of Gastroenterology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.