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Head Face Med 2020 Jun 2;16(1):12. Epub 2020 Jun 2.

Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8525, Japan.

Background: Ameloblastoma is one of the most common benign odontogenic neoplasms. Its surgical excision has the potential to lead to postoperative malocclusion. In this case report, we describe the successful interdisciplinary orthodontic treatment of a patient with ameloblastoma who underwent marginal mandibulectomy. Read More

Plast Reconstr Surg 2020 Jun;145(6):1073e-1088e

Seattle, Wash.; Birmingham, United Kingdom; Lisbon, Portugal; and Ankara, Turkey From the Division of Plastic Surgery, University of Washington; the Craniofacial Center, Seattle Children's Hospital; the Craniofacial Unit, Birmingham Children's Hospital; the Facial Reconstructive Unit, Hospital da Luz; and the Department of Plastic, Reconstructive and Aesthetic Surgery, Hacettepe University Faculty of Medicine.

Learning Objectives: After studying this article and viewing the video, the participant should be able to: 1. Compare the relative stability and neurosensory changes following mandible distraction osteogenesis with those after traditional advancement and fixation. 2. Read More

BMC Anesthesiol 2020 May 20;20(1):120. Epub 2020 May 20.

Department of Anesthesiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 North Lishi Road, XiCheng District, Beijing, 100037, China.

Background: Hemifacial microsomia (HFM) is a congenital craniofacial malformation which is associated with difficult airway. Anesthesiologists may experience difficult intubation in children with HFM. Mandibular distraction could increase the length of the mandible. Read More

Cranio 2020 May 14:1-8. Epub 2020 May 14.

Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Manipal Academy of Higher Education (MAHE), Manipal, India.

The management of patients with a triad of temporomandibular joint (TMJ) ankylosis, retrognathia, and obstructive sleep apnea (OSA) has long been a matter of debate. Even though consensus favors distraction osteogenesis (DO) in the 1st phase of treatment to relieve the OSA, various treatment approaches for TMJ reconstruction after ankylosis release have been put forth. Most of the reconstructive modality has been focused on autogenous materials or customized TMJ prostheses after mandibular distraction. Read More

Plast Reconstr Surg Glob Open 2020 Feb 6;8(2):e2651. Epub 2020 Feb 6.

Department of Plastic and Reconstructive Surgery, Osaka Medical College, Takatsuki City 569-8686; Kawai Orthodontic Dental Clinic, Takatsuki City 569-0804.

Robin sequence is a congenital anomaly, first described by Pierre Robin as a triad of micrognathia, upper airway obstruction and glossoptosis. The most significant airway management technique is the use of distraction osteogenesis to advance the mandible. On the other hand, late complications such as permanent dentition loss and malformation of the damaged teeth have been reported. Read More

J Craniofac Surg 2020 Apr 10. Epub 2020 Apr 10.

Maxillo-Facial Surgery Department.

After a failed mandibular osteodistraction, the wrong positioned mandible of a few patients with Pierre Robin sequence returned in the most functional position and regained a proper symmetry, without external intervention. The study aims to explain this self-adjustment and introduce the floating bone phenomenon.The inclusion criteria were severe micrognathia, Fast and Early Mandibular Distraction Osteogenesis protocol, postoperative mandibular wrong positioning, presurgery, immediate postsurgery, and long-term computed tomography scan. Read More

J Oral Maxillofac Surg 2020 Mar 14. Epub 2020 Mar 14.

Professor, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Kırıkkale University, Kırıkkale, Turkey.

Purpose: The main disadvantage of distraction osteogenesis is the prolonged treatment protocol. Recently, oxytocin (OT) has been found to have anabolic effects on bone metabolism. In this experimental study, the effects of OT on the mandibular distraction gap in rabbits at 2 different distraction rates were evaluated. Read More

Korean J Orthod 2020 Mar 24;50(2):136-144. Epub 2020 Mar 24.

Department of Orthodontics, School of Dentistry, Chonbuk National University, Jeonju, Korea.

Hemifacial microsomia (HFM) patients may experience emotional withdrawal during their growth period due to their abnormal facial appearance. Distraction osteogenesis at an early age to improve their appearance can encourage these patients. Some abnormalities of the affected side can be overcome by distraction osteogenesis at an early age. Read More

Am J Orthod Dentofacial Orthop 2020 04;157(4):439

Shenyang, China.

J Dent Child (Chic) 2020 Jan;87(1):48-52

Dr. Hajishengallis is a professor, graduate program director and chief, Pediatric Dentistry Division, Department of Preventive and Restorative Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pa., USA;, Email:

Infants diagnosed with Pierre Robin sequence frequently have airway obstruction. In severe cases of obstruction, mandibular distraction osteogenesis (MDO) can alleviate the airway blockage through elongation of the mandible and subsequent anterior placement of the tongue. However, there are several complications associated with MDO in the very young child. Read More

J Craniofac Surg 2020 May/Jun;31(3):e277-e280

Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine.

Patients with craniofacial microsomia (CFM) may present with severely malformed mandibles resulting in secondary tongue-based airway obstruction. While surgical management of clinically significant airway obstruction in these patients often involves mandibular distraction osteogenesis (MDO), patients with Pruzansky III CFM typically require additional costochondral bone grafting. In this report, the authors present the successful surgical management of airway obstruction and severe obstructive sleep apnea using a cranio-mandibular fixator (Matthews device) combined with MDO in a 4-year-old female patient with Goldenhar syndrome and associated Pruzansky III CFM. Read More

Oral Maxillofac Surg Clin North Am 2020 May 23;32(2):309-320. Epub 2020 Feb 23.

Craniofacial Center, Divisions of Craniofacial and Plastic Surgery and Oral-Maxillofacial Surgery, Seattle Children's Hospital, 4800 Sand Point Way NE, Seattle, WA 98105, USA. Electronic address:

Subcranial and frontofacial distraction osteogenesis have emerged as powerful tools for management of hypoplasia involving the upper two-thirds of the face. The primary goal of subcranial or frontofacial distraction is to improve the orientation of the upper face and midface structures (frontal bone, orbitozygomatic complex, maxilla, nasal complex) relative to the cranial base, globes, and mandible. The various techniques used are tailored for management of specific phenotypic differences in facial position and may include segmental osteotomies, differential vectors, or synchronous maxillomandibular rotation. Read More

Br J Oral Maxillofac Surg 2020 Apr 23;58(3):324-328. Epub 2020 Jan 23.

Department of Stomatology, First Outpatient Department, Logistics Support Department of Central Military Commission, Beijing 100842, PR China. Electronic address:

Rehabilitation of gunshot injuries that require combined reconstruction of bone and soft tissue poses a considerable challenge. We describe three cases of rehabilitation for mandibular defects and deformities caused by gunshot injuries. After debridement, three kinds of internal distractors were used. Read More

J Craniofac Surg 2020 May/Jun;31(3):e236-e239

Department of Oral and Maxillofacial Surgery, Daejeon Dental Hospital, College of Dentistry.

Odontogenic myxoma is a benign tumor, mostly located in the mandible. It shows locally aggressive behavior and requires surgical removal. Common treatment options for reconstructing the bone defects are immediate or delayed autologous bone graft or free flap. Read More

J Clin Exp Dent 2020 Jan 1;12(1):e52-e58. Epub 2020 Jan 1.

DDS, MSc. Assistant Lecturer, Histology and Embryology Institute, Faculty of Medicine, University of Coimbra, Portugal.

Background: The distraction osteogenesis (DO) is the biological process of new bone formation between the surfaces of bone segments gradually separated by incremental traction. However, the lack of solid experimental studies using the tooth-borne distractor does not allow comparing this technique with the classical procedures. This study aimed to establish the effect of two different activation protocols in new bone formation, with a new intraoral tooth-borne device for dog mandibular distraction osteogenesis. Read More

J Pak Med Assoc 2020 Jan;70(1):24-28

King Edward Medical University, Mayo hospital Lahore.

Objective: To evaluate the efficacy of simultaneous gap arthroplasty and distraction osteogenesis in the treatment of non-syndromic temporomandibular joint ankylosis patients with hypoplastic mandible.

Methods: The descriptive prospective study was conducted at the Department of Oral and Maxillofacial Surgery, King Edward Medical University / Mayo Hospital, Lahore, Pakistan, from January to December, 2016, and comprised patients having temporomandibular joint ankylosis with hypoplastic mandible. Interpositional gap arthoplasty, osteotomy and application of distractor were done in all the patients. Read More

J Craniofac Surg 2020 Mar/Apr;31(2):513-516

Department of Burn and Plastic Surgery, Children's Hospital of Chongqing Medical University, Chongqing, China.

Objective: To present the dynamical evaluation of mandible and upper airway size among Chinese infant patients following mandibular distraction osteogenesis in a short-term follow-up and compare predistraction measurements with a normal age- and sex-matched control.

Methods: All the patients have undergone the computed tomography (CT) scan before mandibular distraction osteogenesis (T0), at the end of the distraction phase (T1), and 3 months after the end of the distraction phase before the distractor removal (T2). A CT analyzing computer software MIMICS was utilized to analyze the anatomic variables of upper airway size and mandible size. Read More

Laryngoscope Investig Otolaryngol 2019 Dec 22;4(6):587-596. Epub 2019 Nov 22.

Laboratoire Regenerative Medicine and Skeleton RMeS, France INSERM, U 1229 Nantes France.

Background: The reconstruction of segmental mandibular defects remains a challenge for the reconstructive surgeon, from both a functional and an esthetic point of view.

Methods: This clinical review examines the different techniques currently in use for mandibular reconstruction as related to a range of etiologies, including the different bone donor sites, the alternatives to free flaps (FFs), as well as the contribution of computer-assisted surgery. Recent progress and the perspectives in bone tissue engineering (BTE) are also discussed. Read More

Medicine (Baltimore) 2019 Dec;98(51):e18339

Department of Anaesthesia and Prioperative Medicine, Guangzhou Women and Children Medical Center.

Mandibular distraction osteogenesis (MDO) is an effective treatment for tongue-based airway obstruction in infants with severe Pierre Robin sequence (PRS). Most infants receiving MDO require postoperative mechanical ventilation (MV) to assist breathing. Optimal MV time for each individual patient and factors influencing the time must be identified to guide clinical decision-making. Read More

Korean J Orthod 2019 Nov 26;49(6):413-426. Epub 2019 Nov 26.

Department of Orthodontics, School of Dentistry, Seoul National University, Seoul, Korea.

This study was performed to describe the longitudinal management of recurrent temporomandibular joint (TMJ) ankylosis from infancy to adulthood in perspective of surgical and orthodontic treatment. A 2-year-old girl was referred with chief complaints of restricted mouth opening and micrognathia due to bilateral TMJ ankylosis. For stage I treatment during early childhood (6 years old), high condylectomy and interpositional arthroplasty were performed. Read More

Medicine (Baltimore) 2019 Dec;98(49):e18290

Department of Prosthodontics and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, South Korea.

Introduction: A resected mandibular edentulous ridge resulting from an ameloblastoma and marginal mandibulectomy is a restorative challenge. To maintain oral hygiene, recurrent examinations, and for long-term maintenance, a removable dental prosthesis is preferred to an implant-supported fixed dental prosthesis.

Patient Concerns: A 28-year-old Asian man was referred for evaluation of a radiolucent area on the right side of the mandible. Read More

Exp Ther Med 2019 Dec 22;18(6):4888-4892. Epub 2019 Oct 22.

Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510055, P.R. China.

Temporomandibular joint (TMJ) ankylosis in pediatric patients is rare and may cause severe micrognathia and obstructive sleep apnea syndrome. The present study reports on the treatment and 4-year follow-up of a pediatric patient with early-onset bilateral TMJ ankylosis and severe secondary micrognathia, as well as obstructive sleep apnea syndrome. A typical 'bird face' appearance was noted with severe mandible retrognathism and a significant convex facial profile. Read More

Am J Orthod Dentofacial Orthop 2019 Dec;156(6):779-790

Wyss Department of Plastic Surgery, New York University, Langone Medical Center, New York, NY. Electronic address:

Introduction: LeFort III distraction osteogenesis may be indicated in the treatment of syndromic craniosynostosis with severe midface retrusion. This study investigates long-term changes in patients undergoing distraction as children, and compares outcomes to an unaffected, untreated control.

Methods: Fifteen patients (9 males, 6 females) with syndromic craniosynostosis treated by LeFort III distraction at an average age of 4. Read More

Indian J Dent Res 2019 Jul-Aug;30(4):625-629

Balaji Dental and Craniofacial Hospital, Teynampet, Chennai, Tamil Nadu, India.

Severe restriction of airway volume in the orofacial region, caused by temporomandibular joint (TMJ) ankylosis, may lead to obstructive sleep apnea (OSA). If the TMJ ankylosis is progressive, rarely, the caregivers may fail to notice the problem. Such patients may have only symptoms of snoring, daytime sleepiness, fatigue, inability to concentrate, and irritability. Read More

J Craniofac Surg 2019 Nov-Dec;30(8):2479-2482

Department of Oral and Maxillofacial Surgery, The Herman Ostrow School of Dentistry, Los Angeles County/USC Medical Center, University of Southern California, Los Angeles, CA.

Objectives: To retrospectively assess malocclusions, skeletal relationships and the functional needs of orthognathic patients treated in a University teaching hospital.

Subjects And Methods: This study used clinical records of 100 consecutive patients [51 female, 49 males, mean (SD) age =21.5 (2. Read More

J Craniofac Surg 2020 Jan/Feb;31(1):e84-e89

Department of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN.

Agnathia-otocephaly complex (AOC) is a rare malformation complex of the first pharyngeal arch that is characterized by agnathia/dysgnathia, microstomia, aglossia/hypoglossia and variable displacement of the ears. Only 11 post-infancy patients with severe AOC have been described in the literature, and the incidence of this malformation complex is estimated to be 1 per 70,000 births. In this brief clinical study, the authors describe the case of an 18-year-old female diagnosed with AOC who underwent a 3-step mandibular distraction protocol with an external distraction device. Read More

J Craniofac Surg 2020 Jan/Feb;31(1):222-225

Department of Oral and Maxillofacial Surgery, University Lille, CHU Lille, INSERM U1008 - Controlled Drug Delivery Systems and Biomaterials.

Introduction: Mandibular distraction osteogenesis (MDO) is an effective treatment for severe micrognathia, as it helps to avoid tracheostomy but has some adverse effects on the temporomandibular joint (TMJ). TMJ ankylosis is a serious condition leading to feeding difficulties and growth impairment, and could result in worse consequences in cases with micrognathia who already have limited growth potential. Here, we aimed to report on cases with TMJ ankylosis-a rare but devastating complication of MDO. Read More

J Craniofac Surg 2019 Nov-Dec;30(8):2530-2532

Division of Plastic and Reconstructive Surgery, University of Utah, Salt Lake City, UT.

Osteogenesis imperfecta (OI) is characterized by brittle bones, premature hearing loss, blue sclera, dental abnormalities, and short stature. Maxillofacial pathology is marked in many OI patients and includes a high incidence of class III malocclusion secondary to a retrusive maxilla relative to both the mandible and cranial base.Review of literature shows that most of the orthognathic surgeries performed in the setting of OI are double jaw surgeries, in the form of maxillary advancement and mandibular setback. Read More

J Craniofac Surg 2019 Nov-Dec;30(8):2509-2511

Craniofacial Orthodontics and Oral-Maxillofacial Surgery, Teeth "N" Jaws Center, Lake Area, Nungambakkam, Chennai, India.

Distraction osteogenesis technique has gained popularity and has been established as a successful procedure in the management of cranio-maxillofacial deformities for more than 2 decades. Varieties of distractor designs were evolved for the procedures in the maxilla and mandible. Various distraction parameters are clinically important as planned in each case. Read More

Int J Surg Case Rep 2019 16;62:144-149. Epub 2019 Aug 16.

Queen's Hospital, United Kingdom. Electronic address:

Introduction: Temporomandibular joint (TMJ) ankylosis is a debilitating mandibular hypomobility disorder that may be associated with serious functional and aesthetic deformities including limited mouth opening, impaired mastication and disturbances of facial and mandibular growth. The ultimate treatment goal of TMJ ankylosis is to restore altered joint mechanics, correct associated dentofacial deformities and prevent reankylosis.

Presentation Of Case: We present a case of a 16 year old patient who returned with excessive mandibular growth and TMJ reankylosis following treatment of TMJ ankylosis with CCGs when he was 8 years old. Read More

J Craniofac Surg 2019 Oct;30(7):2271-2274

Oral and Maxillofacial Surgery, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.

Introduction: Distraction osteogenesis is an integral part in management of mandibular defects associated with hemifacial microsomia and post-ankylotic mandibular defects. The most difficult part in distraction osteogenesis is the prediction of distraction vector and risk of injury to vital structures as inferior alveolar. The present study aimed to present 3-dimensionally constructed computer-guided splints in distraction osteogenesis to get an ideal vector and minimal risk of vital structures injury. Read More

J Craniomaxillofac Surg 2019 Nov 20;47(11):1699-1705. Epub 2019 Aug 20.

Center for Cleft Palate & Craniofacial Malformations, Tübingen University Hospital, Germany; Department of Neonatology and Pediatric Sleep Lab, Tübingen University Hospital, Germany.

Various treatments, many of them considerably invasive, are currently applied to infants with Robin sequence (RS) and accompanying upper airway obstruction (UAO). We present a narrative review of our data on the Tübingen palatal plate (TPP) which show the following: a) in a randomized trial, the TPP was superior to a sham procedure in alleviating UAO; b) children treated with the TPP in infancy showed an intellectual development within the reference range; c) prone positioning is no alternative, as it is ineffective and associated with an increased risk of sudden death; d) the TPP reduces the mixed-obstructive apnea index to near-normal values, both in isolated and most (83%) syndromic RS, e) of 443 infants (129 syndromic) treated with the TPP in our center, 23 (5%) ultimately received a tracheostomy (all with syndromic RS), f) recent data suggest that the TPP may induce mandibular catch-up growth, g) the TPP may also help to reduce respiratory complications following cleft closure in RS, and h) TPP treatment is applied by various centers around the world, although it is unclear if its effectiveness is invariably controlled by endoscopy and sleep studies, although both are necessary. Given these data from peer-reviewed studies, it may be questioned whether the "First do no harm" principle is always adhered to when subjecting RS infants to more invasive procedures such as mandibular distraction osteogenesis or tongue-lip adhesion. Read More

J Stomatol Oral Maxillofac Surg 2020 Jun 30;121(3):242-247. Epub 2019 Aug 30.

Université de Lille, CHU de Lille, INSERM, Department of Oral and Maxillofacial Surgery, U1008 - Controlled Drug Delivery Systems and Biomaterials, 59000 Lille, France.

Introduction: Ginestet introduced the first external device used to fix the mandible in 1936. In 1949, Morris introduced a biphasic fixation device. This "Joe Hall Morris fixation" design led to use of a self-crafted external fixator based on pins connected by a breathing tube filled with dental resin. Read More

J Craniomaxillofac Surg 2019 Oct 19;47(10):1521-1529. Epub 2019 Jul 19.

Department of Medicine and Surgery, Unit of Maxillofacial Surgery, University of Salerno, Salerno, Italy.

Purpose: Mandibular hypoplasia can develop transversely, sagittally, or in both diameters simultaneously. Current techniques achieve either sagittal or transverse expansion with different surgeries. Here, we present a novel method to obtain transverse and sagittal mandibular distraction in one stage. Read More

Br J Oral Maxillofac Surg 2019 10 30;57(8):793-795. Epub 2019 Jul 30.

Consultant in Oral and Maxillofacial Surgery, Great Ormond Street Hospital, London, United Kingdom.

We present a 16-year-old boy with a history of ankylosis of the temporomandibular joint (TMJ) who had been treated with a costochondral graft and mandibular distraction. The distraction seems to have caused pulp canal obliteration of the lower right second premolar and lower right first molar on radiographic examination. To our knowledge this is the only reported instance of such damage related to mandibular distraction. Read More

J Craniomaxillofac Surg 2019 Sep 13;47(9):1343-1350. Epub 2019 Jul 13.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, China. Electronic address:

Background: Postoperative infection is a complication of mandibular distraction osteogenesis (DO) in patients with hemifacial microsomia (HFM). The risk of surgical wound infection in DO is reported to be high due to the long duration of the distraction process. Treatment during the perioperative period is critical in combating infection. Read More

J Craniofac Surg 2019 Nov-Dec;30(8):e743-e746

MDC, Delhi Cantt, India.

Mandibular hypoplasia is a common dentofacial deformity requiring a combination of orthodontic and surgical treatment. Before the introduction of distraction osteogenesis various orthognathic surgical procedures were carried out to treat mandibular hypoplasia. Orthognathic procedures like corpus lengthening by bilateral sagittal split ramus osteotomy and genioplasty are commonly practised all over the world to address the high esthetic demands and functional problems. Read More

Int J Med Sci 2019 2;16(6):831-837. Epub 2019 Jun 2.

Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai JiaoTong University School of Medicine, Shanghai, China.

: To investigate the effects of inferior alveolar nerve on new bone formation in rabbit mandibular distraction osteogenesis. : 20 New Zealand White rabbits underwent bilateral distraction osteogenesis with a rate of 1 mm/day. The inferior alveolar nerve of one side was resected under the surgical microscope, with the inferior alveolar vascular intact. Read More

J Craniofac Surg 2019 Sep;30(6):1667-1670

Department of Plastic Surgery, University of Tennessee Health Science Center.

The aim of the present study was to present a single center's experience with mandibular distraction osteogenesis (MDO) in Pierre Robin sequence (PRS) patients. A retrospective chart review was performed to identify patients with PRS that underwent MDO at our institution from 2003 to 2012. Inclusion criteria were as follows:Evaluation included demographic information, postoperative complications, and surgical outcomes. Read More

Otolaryngol Head Neck Surg 2019 11 23;161(5):870-876. Epub 2019 Jul 23.

Tufts University School of Medicine, Boston, Massachusetts, USA.

Objectives: To assess for differences in postoperative care following mandibular distraction osteogenesis (MDO) in infants before and after implementation of a standardized protocol.

Study Design: Retrospective chart review.

Setting: Urban tertiary pediatric hospital. Read More

J Craniofac Surg 2019 Sep;30(6):1866-1868

Division of Plastic Surgery at Texas Children's Hospital/ Michael E. DeBakey, Department of Surgery, Baylor College of Medicine, Houston, TX.

Pierre Robin sequence is a triad of micrognathia, glossoptosis, and airway obstruction that has reported associations with numerous birth defects and anomalies including craniocervical pathologies. Given the number of airway assessments and neck manipulations these neonates experience, undetected cervical instability can result in detrimental consequences. The authors present a case of a neonate with non-syndromic Pierre Robin sequence planned for mandibular distraction osteogenesis that developed abnormal motor activity following intubation. Read More

J Craniofac Surg 2019 Nov-Dec;30(8):e714-e717

Sharjah Institute for Medical Research (SIMR), University of Sharjah, United Arab Emirates.

Temporomandibular joint ankylosis in children commonly lead to difficulty in feeding, poor oral hygiene, retrognathic mandible and obstructive sleep apnea. Surgical release of the ankylosis has always been the standard treatment. The authors report a 12 year old boy with unilateral temporomandibular joint ankylosis and obstructive sleep apnea underwent surgical release of the ankylosis with successful gain in mouth opening. Read More

Int Orthod 2019 09 24;17(3):580-595. Epub 2019 Jun 24.

ESIC Dental College and Hospital, Department of Oral and Maxillofacial Surgery, Sector 15, Rohini, 110089 Delhi, India.

Despite being one of the most pervasive debilitating skeletal problems in the craniofacial region, surgical-orthodontic management of long-standing asymmetric Class II dentofacial deformities is often a unique challenge posed to the clinicians. This case report describes the encouraging results of systematically sequenced and staged therapeutic approach adopted for successful rehabilitation of an adult patient with asymmetric Class II dentofacial deformity with mandibular micrognathia secondary to unilateral TMJ ankylosis. Concurrent gap arthroplasty and bilateral distraction of mandibular body were performed during the first operation for functional restoration of mandibular movements and correction of mandibular micrognathia and associated asymmetry. Read More

J Craniofac Surg 2019 Nov-Dec;30(8):2315-2318

Department of Histology and Embriyology, Ataturk Training and Research Hospital, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey.

The long consolidation period of distraction osteogenesis (DO) may lead to complications such as pain, infection, fracture, scar formation, malunion and delayed union. The aim of this study was to evaluate the effect of systemic Vitamin E application during mandibular DO on new bone regeneration in a rabbit model. 16 adult male 8 months old New Zealand rabbits underwent mandibular lengthening with a distractor for the study. Read More

Br J Oral Maxillofac Surg 2019 09 13;57(7):701-703. Epub 2019 Jun 13.

State Key Laboratory of Oral Diseases and Center of Orthognathic & TMJ Surgery, West China Stomatology, Sichuan University, Chengdu, China. Electronic address:

Clin Ter 2019 May-Jun;170(3):e174-e176

Dentistry Unit, Department of Pediatric Surgery, Bambino Gesù Children's Research Hospital, Rome, Italy.

Aims: The aim of this retrospective work on 30 patients affected by dento-skeletal III class and Infantile Swallowing (I.S.), treated between 2006 and 2014, is to analyze the causes of eventual surgical relapses and to underline the consequences of untreated Infantile Swallowing. Read More

Am J Orthod Dentofacial Orthop 2019 Jun;155(6):801-811

Department of Orthodontics, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. Electronic address:

Introduction: The purpose of this study was to evaluate the therapeutic effect of a hybrid treatment for hemifacial microsomia that combines distraction osteogenesis and a mandible-guided functional appliance to correct mandibular asymmetry.

Methods: This was a retrospective analysis of 10 patients with unilateral hemifacial microsomia who underwent mandibular ramus distraction osteogenesis in our hospital from February 2013 to July 2015. The cases were classified into 2 comparison groups: 5 patients were in the MG-DO group (distraction osteogenesis combined with an mandible-guided functional appliance) and 5 in the control group (distraction osteogenesis only). Read More

Int J Oral Maxillofac Surg 2019 Dec 10;48(12):1584-1593. Epub 2019 May 10.

Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Rehabilitation of the atrophic posterior mandible is a challenge in dental practice. Conventional treatments include the segmental sandwich osteotomy or inlay bone grafting (IBG), onlay bone grafting (OBG), short implants, distraction osteogenesis, and inferior alveolar nerve transposition (IANT), each with its downsides. This case series is reported to introduce a modification of IBG - pedicled segmental rotation (PSR) for the reconstruction of co-existing vertical and horizontal defects in the posterior mandible. Read More

PLoS One 2019 25;14(4):e0215875. Epub 2019 Apr 25.

Institute of Veterinary Anatomy, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.

Over many decades, the Göttingen Minipig has been used as a large animal model in experimental surgical research of the mandible. Recently several authors have raised concerns over the use of the Göttingen Minipig in this research area, observing problems with post-operative wound healing and loosening implants. To reduce these complications during and after surgery and to improve animal welfare in mandibular surgery research, the present study elucidated how comparable the mandible of minipigs is to that of humans and whether these complications could be caused by specific anatomical characteristics of the minipigs' mandible, its masticatory muscles and associated vasculature. Read More

Medicine (Baltimore) 2019 Mar;98(10):e14754

Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.

Pierre Robin sequence (PRS) is a congenital malformation characterized by micrognathia, glossocoma, and mechanical obstruction of the upper respiratory tract. These deformities impair respiration, sleep, feeding, and swallowing, and can lead to malnutrition, stunted development, and death. Bilateral mandibular distraction osteogenesis, whereby the mandible and tongue root are extended outward, is the standard treatment to relieve upper airway obstruction in severe PRS. Read More