214,456 results match your criteria Distal Clavicle Osteolysis


A Family with Autosomal Dominant Distal Renal Tubular Acidosis Presents with Atypical Phenotype Caused by a Missence Mutation (R388C) of the Human Kidney Anion Exchanger.

Nephron 2018 Dec 14:1-6. Epub 2018 Dec 14.

Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang,

Hereditary forms of distal renal tubular acidosis (dRTA) are rare and mainly caused by mutations in ATP6V1B1, ATP6V0A4 and SLC4A1. About 20 mutations in SLC4A1 gene have been found that are related to either autosomal dominant (AD) or autosomal recessive dRTA. AD dRTA often manifest as constitutional and can easily be delayed in diagnosis and treatment. Read More

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December 2018

Contralateral acute vascular occlusion following revascularization surgery for moyamoya disease.

Authors:

J Neurosurg 2018 Dec 14:1-7. Epub 2018 Dec 14.

OBJECTIVERevascularization surgery is a safe and effective surgical treatment for symptomatic moyamoya disease (MMD) and has been shown to reduce the frequency of future ischemic events and improve quality of life in affected patients. The authors sought to investigate the occurrence of acute perioperative occlusion of the contralateral internal carotid artery (ICA) with contralateral stroke following revascularization surgery, a rare complication that has not been previously reported.METHODSThis study is a retrospective review of a prospective database of a single surgeon's series of revascularization operations in patients with MMD. Read More

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December 2018

An examination of child protective service involvement among children born to mothers in foster care.

Child Abuse Negl 2018 Dec 13;88:317-325. Epub 2018 Dec 13.

Children's Data Network, School of Social Work, School of Social Work, University of Southern California, United States; California Child Welfare Indicators Project, School of Social Welfare, University of California, Berkeley, United States.

Objective: This study identified children born to mothers in foster care and documented Child Protective Service (CPS) involvement among children.

Methods: Probabilistically linked birth and CPS records from California (2009-2012) were used to identify all mothers in foster care on or after conception. Children were followed prospectively using linked records to identify CPS involvement occurring during the first three years of life. Read More

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December 2018

Occurrence, diversity, and persistence of antibiotic resistant enterococci in full-scale constructed wetlands treating urban wastewater in Sicily.

Bioresour Technol 2018 Dec 8;274:468-478. Epub 2018 Dec 8.

Department of Agriculture, Food and Environment (Di3A), University of Catania, Via Santa Sofia 100, Catania 95123, Italy.

Enterococci isolated from different sites of an urban wastewater treatment plant (consisting of three horizontal subsurface flow constructed wetlands) were investigated. One-hundred-thirty isolates were identified at species level and tested for resistance to eleven antibiotics, by microdilution method, and their clonal relatedness was established by SmaI-PFGE analysis. Results highlighted the persistence of enterococcal population in all effluents and the dominance of E. Read More

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December 2018

CRISPR/Cas9 deletions in a conserved exon of Distal-less generates gains and losses in a recently acquired morphological novelty in flies.

iScience 2018 Dec 1;10:222-233. Epub 2018 Dec 1.

Department of Biological Sciences, National University of Singapore, Singapore, Singapore. Electronic address:

Distal-less has been repeatedly co-opted for the development of many novel traits. Here, we document its curious role in the development of a novel abdominal appendage ("sternite brushes") in sepsid flies. CRISPR/Cas9 deletions in the homeodomain result in losses of sternite brushes, demonstrating that Distal-less is necessary for their development. Read More

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December 2018

ng inputs that may arise from the field Decision tool for climate disasters and infectious disease at sub-national level in India: Ensuring a paradigm shift in health planning from prevalence to vulnerability.

Acta Trop 2018 Dec 13. Epub 2018 Dec 13.

Indian Institute of Public Administration, Delhi, India.

Climate change is considered as a distal determinant of public health which is increasing in importance. India, as an example, has a national action plan for climate change and human health. Sub-national (State) plans for climate change also exist, taking into account the health sector. Read More

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December 2018

Effects of high-soy diet on S100 gene expression in liver and intestine of rainbow trout (Oncorhynchus mykiss).

Fish Shellfish Immunol 2018 Dec 13. Epub 2018 Dec 13.

Aquaculture Research Institute, University of Idaho, 3059F National Fish Hatchery Rd, Hagerman, ID, 83332, USA.

The current study examines expression of S100 genes, a group of calcium-sensing proteins poorly characterized in fishes. In mammals, these proteins are known to play roles beyond calcium-signaling, including mediation of inflammatory processes. Some S100 proteins also serve as biomarkers for a variety of autoinflammatory conditions. Read More

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December 2018

Cortical porosity assessment in the distal radius: A comparison of HR-pQCT measures with Synchrotron-Radiation micro-CT-based measures.

Bone 2018 Dec 13. Epub 2018 Dec 13.

Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, SK, Canada. Electronic address:

Objective: To determine the agreement between cortical porosity derived from high resolution peripheral quantitative computed tomography (HR-pQCT) (via standard threshold, mean density and density inhomogeneity methods) and synchrotron radiation micro-CT (SR-μCT) derived porosity at the distal radius.

Methods: We scanned 10 cadaveric radii (mean donor age: 79, SD 11 years) at the standard distal region using HR-pQCT and SR-μCT at voxel sizes of 82 μm and 17.7 μm, respectively. Read More

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December 2018

A fungicide miconazole ameliorates tri-o-cresyl phosphate-induced demyelination through inhibition of ErbB/Akt pathway.

Neuropharmacology 2018 Dec 13. Epub 2018 Dec 13.

Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1-5 Beichenxilu Road, Beijing, 100101, China. Electronic address:

Organophosphorus compound (OP)-induced delayed neurotoxicity (OPIDN) is characterized by distal axonal degeneration and demyelination of the central and peripheral axons, which leads to progressive muscle weakness, ataxia and paralysis in several days after OP intoxication. This study aimed to investigate the possible use of an imidazole fungicide miconazole as a novel therapy for OPIDN. Adult hens, the most commonly used animal models in OPIDN studies, were orally given tri-o-cresyl phosphate (TOCP). Read More

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December 2018

Ligand binding domain interface: A tipping point for pharmacological agents binding with GluN1/2A subunit containing NMDA receptors.

Eur J Pharmacol 2018 Dec 13. Epub 2018 Dec 13.

Edward Via Virginia College of Osteopathic Medicine, Technical University, Darmstadt, Germany; Virginia-Maryland College of Veterinary MedicineVirginia Tech, Blacksburg, VA, USA; School of Neuroscience, Virginia Tech, Blacksburg, VA, USA. Electronic address:

N-methyl D-aspartate (NMDA) receptors play a crucial role in normal brain function, pathogenesis of neurodegenerative and psychiatric disorders. Functional tetra-heteromeric NMDA receptor contains two obligatory GluN1 subunits and two identical or different non-GluN1 subunits that evolve from six different genes including four GluN2 (A-D) and two GluN3 (A-B) subunits. Since NMDA receptors confer varied physiological properties and spatiotemporal distributions in the brain, pharmacological agents that target NMDA receptors with specific GluN2 subunits have significant potential for therapeutic applications. Read More

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December 2018

Clinical Comparison Between Shortening Osteotomy of the Proximal Phalanx Neck and Arthrodesis in Hammer Toe Surgery at Mid-TermFollow-Up.

J Foot Ankle Surg 2018 Dec 13. Epub 2018 Dec 13.

Professor, Department of Orthopaedics & Traumatology, Santa Maria della Misericordia Hospital, University of Perugia, Perugia, Italy.

The treatment of hammer toe has been advocated for years, and many procedures have been proposed with skeletal and soft tissue intervention. The purpose of the present study was to compare arthrodesis of the proximal interphalangeal joint with shortening osteotomy of the proximal phalanx neck. In most cases, both procedures have been associated with elongation of the extensor apparatus, capsulotomy of the metatarsophalangeal joint, and stabilization with a Kirschner wire. Read More

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December 2018

Using bifurcated endoprosthesis after iliac artery recanalization for concomitant abdominal aortic aneurysm and chronic total occlusions of access routes.

J Vasc Surg 2018 Dec 12. Epub 2018 Dec 12.

Division of Vascular Surgery, Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.

Objective: Concurrent abdominal aortic aneurysm (AAA) and unilateral iliac occlusion is a challenge in the implantation of bifurcated stent grafts (BFGs). The endovascular approach is less invasive than open surgery; the aortouni-iliac (AUI) graft with crossover femorofemoral bypass (CFFB) has many problems associated with extra-anatomic reconstruction. We attempted endovascular aneurysm repair (EVAR) using BFGs in such cases and evaluated the outcomes. Read More

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December 2018

Endograft migration after thoracic endovascular aortic repair.

J Vasc Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Vascular and Endovascular Surgery, University Hospital Heidelberg, Heidelberg, Germany.

Objective: The objective of this study was to evaluate the incidence, timing, and potential risk factors of late endograft migration after thoracic endovascular aortic repair (TEVAR).

Methods: A retrospective analysis was conducted of 123 patients receiving TEVAR for thoracic aortic aneurysms (TAAs), dissections, penetrating aortic ulcer, intramural hematoma, or traumatic transection between January 2005 and December 2015 with a minimum imaging-based follow-up of 6 months. Imaging analysis was performed by three independent readers. Read More

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December 2018

Late onset distal myopathy: A new telethoninopathy.

Neuromuscul Disord 2018 Nov 13. Epub 2018 Nov 13.

Unidad de Neuromuscular, Hospital Universitario 12 de Octubre, Instituto i+12 y U-723 del CIBERER, Spain.

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November 2018

Late outcomes of strategic arch resection in acute type A aortic dissection.

J Thorac Cardiovasc Surg 2018 Nov 14. Epub 2018 Nov 14.

Department of Cardiac Surgery, Michigan Medicine, Ann Arbor, Mich.

Objective: To compare perioperative and long-term outcomes in patients undergoing hemiarch and aggressive arch replacement for acute type A aortic dissection (ATAAD).

Methods: From 1996 to 2017, we compared outcomes of hemiarch (n = 322) versus aggressive arch replacements (zones 2 and 3 arch replacement with implantation of 2-4 arch branches, n = 150) in ATAAD. Indications for aggressive arch were arch aneurysm >4 cm or intimal tear in the aortic arch that was not resectable by hemiarch replacement, or dissection of arch branches with malperfusion. Read More

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November 2018

Distal Landing in TEVAR: Challenges in Reaching "The Dead Centre".

Authors:
Bartosz Rylski

Eur J Vasc Endovasc Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiovascular Surgery, Heart Centre Freiburg University, Freiburg, Germany; Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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December 2018

Towards viscoelastic characterisation of the human ulnar nerve: An early assessment using embalmed cadavers.

Med Eng Phys 2018 Dec 13. Epub 2018 Dec 13.

Department of Anatomy, College of Medical and Dental Sciences, University of Birmingham, United Kingdom. Electronic address:

Cubital tunnel syndrome is the most prevalent neuropathy of the ulnar nerve and its aetiology is controversial. Potential replacement materials should display similar viscoelastic properties. The purpose of this study was to assess the feasibility and merit of quantifying the frequency-dependent viscoelastic properties of proximal and distal sections of the human ulnar nerve. Read More

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December 2018

Morphologic characteristics of severe basilar artery atherosclerotic stenosis on 3D high-resolution MRI.

BMC Neurol 2018 Dec 15;18(1):206. Epub 2018 Dec 15.

Department of Radiology, China-Japan Friendship Hospital, 2 Yinghuayuan Dongjie, Beijing, China.

Background: Two-dimensional high-resolution MRI (2D HRMRI) faces many technical challenges for fully assessing morphologic characteristics of inherent tortuous basilar arteries. Our aim was to investigate remodeling mechanisms and plaque distribution in symptomatic patients with basilar artery stenosis on three-dimensional (3D) HRMRI.

Methods: Forty-six consecutive patients with symptomatic basilar artery atherosclerotic stenosis on MRA (70-99%) were enrolled. Read More

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December 2018

Effect of taping and its conditions on electromyographic responses of knee extensor muscles.

Authors:
Kohei Watanabe

Hum Mov Sci 2018 Dec 12;63:148-155. Epub 2018 Dec 12.

Laboratory of Neuromuscular Biomechanics, School of International Liberal Studies, Chukyo University, Nagoya, Japan. Electronic address:

Introduction: The present study investigated the effect of stretchable characteristics of elastic therapeutic tape and its elongation on surface electromyography (EMG) of knee extensor muscles during knee extension movements.

Methods: Nine healthy men performed knee extension movement with the application of normal elastic tape or highly stretchable tape and without the tapes (control). Tapes were applied on the anterior thigh to cross the knee joint with no elongation and elongation of 50 and 75% of the maximum stretchability. Read More

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December 2018
1 Read

Protective effect of low-intensity transcranial ultrasound stimulation after differing delay following an acute ischemic stroke.

Brain Res Bull 2018 Dec 12. Epub 2018 Dec 12.

Scientific Clinical Specialist, Siemens Ltd., Beijing, China.

Background: Ischemic stroke is a clinically common disease requiring early treatment in the acute period of stroke onset. Such early treatment reduces the level of brain injury, promotes functional recovery, and improves long-term prognosis. Previous studies have demonstrated that, in the event of an acute ischemic stroke, low-intensity transcranial ultrasound stimulation (LITUS) can provide neuroprotection. Read More

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December 2018
1 Read

Middle- and long-term outcomes of hybrid technique of complicated Stanford type-B aortic dissection.

Ann Thorac Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Cardiovascular Surgery, the second Hospital of Jilin University, Changchun, Jilin, China, 130041. Electronic address:

Background: To evaluate the middle- and long- clinical outcomes of aortic implantation of stent-grafts under direct vision (hybrid surgical treatment).

Methods: From March 2009 to December 2014, 285 patients presented with type-B aortic dissection. Of these, 35 complicated patients underwent hybrid surgical treatment. Read More

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December 2018

Physician referral to a psychologist: Testing alternative behavioral healthcare seeking models.

J Clin Psychol 2018 Dec 15. Epub 2018 Dec 15.

Psychology Department, Virginia Commonwealth University, Richmond, Virginia.

Objective: Primary care physicians (PCPs) often refer patients to psychological services, but help-seeking factors in the context of behavioral healthcare referral are understudied. This study examined perceptions of seeking psychological help for depression by comparing alternative structural equation models derived from the Theory of Reasoned Action (TRA).

Method: Internet survey participants (N = 685 US adults, 77% female, M  = 45) imagined themselves in a vignette scenario in which they are experiencing depression symptoms and encouraged by a PCP to see a psychologist. Read More

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December 2018

Niche Partitioning in Theropod Dinosaurs: Diet and Habitat Preference in Predators from the Uppermost Cedar Mountain Formation (Utah, U.S.A.).

Sci Rep 2018 Dec 14;8(1):17872. Epub 2018 Dec 14.

Department of Biology, University of Oklahoma, Norman, Oklahoma, 73072, USA.

We explore hypothetical ecologies to explain diversity among predatory dinosaurs in North America's medial Cretaceous, based on occurrence, tooth morphology, and stable isotope analysis. The Mussentuchit local fauna, Utah, USA, is among the best-known terrestrial vertebrate assemblages from the Cretaceous. Study samples include teeth from six microvertebrate sites, ranging in depositional setting from distal floodplain to channel lags. Read More

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December 2018

Acute Pancreatitis Caused by Ampullary Duodenum Adenoma in a Patient with Adenomatous Polyposis Coli with Billroth II Reconstruction After Distal Gastrectomy.

Am J Case Rep 2018 Dec 15;19:1495-1498. Epub 2018 Dec 15.

Department of Gastroenterology, Kita-Harima Medical Center, Ichiba, Ono, Hyogo, Japan.

BACKGROUND Adenomatous polyposis coli is an autosomal dominant hereditary disorder. Duodenal adenocarcinoma and adenoma, which are extracolonic lesions, not only affect the prognosis of patients but also cause acute pancreatitis. CASE REPORT We present the case of a 73-year-old male. Read More

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December 2018

Cost-effectiveness analysis of total elbow arthroplasty versus open reduction-internal fixation for distal humeral fractures.

J Shoulder Elbow Surg 2019 Jan;28(1):102-111

Division of Sports Medicine, Midwest Orthopaedics at Rush, Rush University Medical Center, Chicago, IL, USA.

Background: Total elbow arthroplasty (TEA) and open reduction-internal fixation (ORIF) are 2 viable surgical treatment options for acute, intra-articular distal humeral fractures in elderly patients. Whereas recent systematic reviews and randomized trials have suggested that TEA and ORIF result in similar functional outcome scores, no previous study has assessed the comparative cost-effectiveness between TEA and distal humeral ORIF in this specific demographic.

Methods: A Markov model was created with the highest-level data available from the literature depicting transitioning health states based on treatment strategies. Read More

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January 2019
1 Read

Unilateral subcutaneous fibroma in the distal femoral region of a 5-year-old Nooitgedacht mare.

J S Afr Vet Assoc 2018 Dec 5;89(0):e1-e4. Epub 2018 Dec 5.

Department of Companion Animal Clinical Studies, University of Pretoria.

A non-ossified unilateral subcutaneous fibroma was diagnosed in the distal femoral region of a 5-year-old Nooitgedacht mare. Histopathological examination of the excised mass revealed long interweaving bundles of semi-mature monotonous collagenous connective tissue with fusiform nuclei without mitotic figures. The mare made an uneventful recovery following surgical removal of the neoplasm. Read More

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December 2018
1 Read

Corrective wedge ostectomy for an atypical femoral procurvatum deformity stabilised with a supracondylar bone plate.

J S Afr Vet Assoc 2018 Dec 5;89(0):e1-e6. Epub 2018 Dec 5.

Translational Research and Animal Clinical Trial Study Group (TRACTS), U-Vet Veterinary Teaching Hospital, University of Melbourne.

Physeal fractures of the distal femur are among the most commonly encountered fractures in skeletally immature dogs. These fractures respond poorly to conservative management and thus early surgical reduction and stabilisation are recommended. A 7-month-old intact male Border collie presented with a history of chronic lameness. Read More

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December 2018

Biosynthetic Oligoclonal Antivenom (BOA) for Snakebite and Next-Generation Treatments for Snakebite Victims.

Toxins (Basel) 2018 Dec 13;10(12). Epub 2018 Dec 13.

Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.

Snakebite envenoming is a neglected tropical disease that each year claims the lives of 80,000⁻140,000 victims worldwide. The only effective treatment against envenoming involves intravenous administration of antivenoms that comprise antibodies that have been isolated from the plasma of immunized animals, typically horses. The drawbacks of such conventional horse-derived antivenoms include their propensity for causing allergenic adverse reactions due to their heterologous and foreign nature, an inability to effectively neutralize toxins in distal tissue, a low content of toxin-neutralizing antibodies, and a complex manufacturing process that is dependent on husbandry and procurement of snake venoms. Read More

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December 2018
1 Read

Knockdown of lncRNA DLX6-AS1 inhibits cell proliferation, migration and invasion while promotes apoptosis by downregulating PRR11 expression and upregulating miR-144 in non-small cell lung cancer.

Biomed Pharmacother 2019 Jan 26;109:1851-1859. Epub 2018 Nov 26.

Department Five of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Background: Long non-coding RNA (lncRNA) distal-less homeobox 6 antisense 1 (DLX6-AS1) was reported to be dysregulated in lung cancer. However, detailed roles of DLX6-AS1 in the pathogenesis of non-small cell lung cancer (NSCLC) were largely unknown.

Methods: The expression of DLX6-AS1 was measured in NSCLC tissues and cells by quantitative real-time PCR (qRT-PCR). Read More

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January 2019
2.023 Impact Factor

Clipping of Basilar Perforator Pure Arterial Malformation Aneurysm: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.

University of Miami, Department of Neurosurgery, Miami, Florida.

Pure arterial malformations are rarely-encountered intracranial lesions, often mistaken for arteriovenous malformations. A minority of these lesions may harbor associated aneurysms. In a recent series of 12 patients with pure arterial malformations, 3 patients had associated aneurysms. Read More

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December 2018

Microcontainers for protection of oral vaccines, in vitro and in vivo evaluation.

J Control Release 2018 Dec 12;294:91-101. Epub 2018 Dec 12.

Department of Micro- and Nanotechnology, Technical University of Denmark, Oersteds Plads 345C, 2800 Kgs., Lyngby, Denmark.

Oral vaccines are highly desirable due to simple logistics, mass vaccination potential and for mucosal immunity. Subunit vaccines are preferred due to high safety, but are inherently difficult to deliver orally, thus providing motivation for the use of advanced oral delivery systems. Polymeric devices in micrometer size (microcontainers) were tested here for this purpose. Read More

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December 2018
1 Read

Osteocytes reflect a pro-inflammatory state following spinal cord injury in a rodent model.

Bone 2018 Dec 11. Epub 2018 Dec 11.

Department of Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center, Bryan, TX, United States of America.

Profound bone loss occurs following spinal cord injury (SCI) resulting in a high incidence of fractures. While likely caused in part by loss of weight-bearing, there is greater bone loss following SCI when compared to that observed in other disuse animal models. Patients with SCI have a protracted inflammatory response, with elevated circulating levels of pro-inflammatory markers. Read More

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December 2018

Too soon to worry? Longitudinal examination of financial planning for retirement among Spanish aged workers.

PLoS One 2018 14;13(12):e0209434. Epub 2018 Dec 14.

National Distance Education University (UNED), Department of Social and Organizational Psychology, Madrid, Spain.

The present study analyzes the relationship between three distal antecedents-financial literacy, confidence in retirement, and economic well-being-and financial planning for retirement evaluated at two different times. We used longitudinal data with repeated measures of financial planning for retirement obtained from a sample (N = 269) of active Spanish workers aged 45-62 years. The results confirm that self-perceived financial knowledge, confidence in retirement, and economic well-being are associated with financial planning for retirement at three and six months. Read More

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December 2018

Ruptured Extensor Pollicis Longus Tendon After a Nondisplaced Distal Radius Fracture in a Young Adult Soccer Player.

Clin J Sport Med 2018 Dec 13. Epub 2018 Dec 13.

HealthONE Family Medicine Residency, Lone Tree, Colorado.

Forearm fractures of the distal radius are one of the most common fractures seen in the upper extremity, and they represent approximately 1/6 of fractures treated in the emergency department. Forearm fractures are associated with a rare but known complication of a delayed ruptured extensor pollicis longus (EPL) tendon. This sequela is more commonly seen in adults after a nondisplaced distal radius fracture, with much variability in the incidence ranging from 0. Read More

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December 2018

Cardiopulmonary phenotypic discordance is common in Duchenne muscular dystrophy.

Pediatr Pulmonol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, MetroHealth Medical Center, Cleveland, Ohio.

Objective: To determine the prevalence of discordant cardiopulmonary function among patients with Duchenne muscular dystrophy (DMD) in our clinic.

Methods: Retrospective chart review from 1999 to 2017.

Inclusion Criteria: DMD patients age ≥ 18 years, alive, with discordant cardiopulmonary function. Read More

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December 2018
1 Read

Diabetes-free survival after extended distal pancreatectomy and islet auto transplantation for benign or borderline/malignant lesions of the pancreas.

Am J Transplant 2018 Dec 14. Epub 2018 Dec 14.

Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Islet autotransplantation is particularly attractive to prevent diabetes after extended pancreatectomy for benign or borderline/malignant pancreas disease. Between 2008 and 2018, 25 patients underwent left extended pancreatectomy (>60%) and islet autotransplantation for neoplasm located in the pancreatic neck or proximal body. Overall, disease-free and diabetes-free survivals were estimated and compared with those observed in 68 non diabetic patients who underwent distal pancreatectomy for pancreatic neoplasms without islet autotransplantation. Read More

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December 2018

Genome-Wide Maps of Transcription Regulatory Elements and Transcription Enhancers in Development and Disease.

Compr Physiol 2018 Dec 13;9(1):439-455. Epub 2018 Dec 13.

Blood Research Institute, BloodCenter of Wisconsin, a part of Versiti, Milwaukee, Wisconsin, USA.

Gene expression is regulated by numerous elements including enhancers, insulators, transcription factors, and architectural proteins. Regions of DNA distal to the transcriptional start site, called enhancers, play a central role in the temporal and tissue-specific regulation of gene expression through RNA polymerase II. The identification of enhancers and other cis regulatory elements has largely been possible due to advances in next generation sequencing technologies. Read More

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December 2018
2 Reads

Renal Chloride Channels in Relation to Sodium Chloride Transport.

Compr Physiol 2018 Dec 13;9(1):301-342. Epub 2018 Dec 13.

Sorbonne Université, CNRS, INSERM, Centre de recherche des Cordeliers, Equipe Métabolisme et Physiologie Rénale, Paris, France.

The many mechanisms governing NaCl absorption in the diverse parts of the renal tubule have been largely elucidated, although some of them, as neutral NaCl absorption across the cortical collecting duct or regulation through with-no-lysine (WNK) kinases have emerged only recently. Chloride channels, which are important players in these processes, at least in the distal nephron, are the focus of this review. Over the last 20-year period, experimental studies using molecular, electrophysiological, and physiological/functional approaches have deepened and renewed our views on chloride channels and their role in renal function. Read More

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December 2018
1 Read

Trabecular bone structure in the distal femur of humans, apes, and baboons.

Anat Rec (Hoboken) 2018 Dec 12. Epub 2018 Dec 12.

Department of Anthropology, Pennsylvania State University, University Park PA 16801.

Trabecular bone structure has been used to investigate the relationship between skeletal form and locomotor behavior on the premise that trabecular bone remodels in response to loading during an animal's lifetime. The aim of this study is to characterize human distal femoral trabecular bone structure in comparison to three non-human primate taxa and relate the patterns of trabecular structural variation in the distal femur to knee posture during habitual locomotor behavior. A whole-epiphysis approach was applied using microCT scans of the distal femora of extant Homo sapiens, Pan troglodytes, Pongo pygmaeus, and Papio spp. Read More

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December 2018

Genetic variants in DNMT1 and the risk of cardiac autonomic neuropathy in females with Type 1 diabetes.

J Diabetes Investig 2018 Dec 11. Epub 2018 Dec 11.

Laboratório de Carboidratos e Radioimunoensaio LIM-18, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR. Av. Dr. Arnaldo, 455São Paulo, SP, BR.

Aims/introduction: Epigenetics participate in the pathogenesis of metabolic memory, a situation in which hyperglycemia exerts prolonged deleterious effects even after its normalization. We tested the hypothesis that genetic variants in an epigenetic gene could predispose to diabetes complications.

Material And Methods: We assessed the frequency of 5 single nucleotide polymorphisms (SNPs) in the gene encoding DNA methytransferase 1 (DNMT1; rs8112895, rs7254567, rs11085721, rs17291414, and rs10854076) and their associations with diabetic kidney disease, retinopathy, distal polyneuropathy and autonomic cardiovascular neuropathy (CAN) in 359 long-term Type 1 diabetes individuals. Read More

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December 2018
1 Read

Atypical actinobacillosis affecting hind limbs and lungs in a single beef cattle herd.

J Vet Intern Med 2018 Dec 12. Epub 2018 Dec 12.

Clinic for Ruminants, Nantes, France.

Actinobacillosis usually is a sporadic infection that affects the tongue in cattle ("wooden tongue") with possible spread to the digestive tract. Two 4-year-old Rouge-des-Prés cows from a single French beef herd were referred for chronic (2-6 months) swelling and cutaneous nodules in the distal hind limbs. In addition to cutaneous signs, physical examination disclosed cachexia, lameness, lymphadenitis of the hind limbs, and pneumonia in both cows. Read More

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December 2018
1 Read

Three-dimensional analysis reveals altered chromatin interaction by enhancer inhibitors harbors TCF7L2-regulated cancer gene signature.

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Biomedical Health Sciences Department, University of Vermont, Burlington, VT, USA.

Distal regulatory elements influence the activity of gene promoters through chromatin looping. Chromosome conformation capture (3C) methods permit identification of chromatin contacts across different regions of the genome. However, due to limitations in the resolution of these methods, the detection of functional chromatin interactions remains a challenge. Read More

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December 2018

figHigh Spatial Resolution MALDI-MS Imaging in the Study of Membranous Nephropathy.

Proteomics Clin Appl 2018 Dec 7:e1800016. Epub 2018 Dec 7.

University of Milano-Bicocca, Department of Medicine and Surgery, Clinical Proteomics and Metabolomics Unit, Vedano al Lambro, Italy.

MALDI-MSI technology has advanced rapidly during recent years with the development of instruments equipped with low-diameter lasers that are suitable for high spatial resolution imaging. This may provide significant advantages in certain fields of molecular pathology where more specific protein fingerprints of individual cell types are required, such as renal pathology. Here we performed MALDI-MSI analysis of a cohort of MN patients among which patients either responded favourably (R; n = 6), or unfavourably (NR; n = 4), to immunosuppressive treatment (Ponticelli Regimen), employing a 10μm laser spot diameter. Read More

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December 2018

Long noncoding RNA HOTTIP mediates SRF expression through sponging miR-150 in hepatic stellate cells.

J Cell Mol Med 2018 Dec 8. Epub 2018 Dec 8.

Departments of Gastroenterology and Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

HOXA transcript at the distal tip (HOTTIP) has been shown to be up-regulated in a variety of cancers and is identified as an oncogenic long noncoding RNA. However, the biological role of HOTTIP in liver fibrosis is unclear. Here, we reported that HOTTIP was specifically overexpressed in activated hepatic stellate cells (HSCs). Read More

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December 2018

External validation of Imamura nomogram as a tool to predict preoperatively laser semi-rigid ureterolithotripsy outcomes.

Minerva Urol Nefrol 2018 Dec 14. Epub 2018 Dec 14.

Department of Urology, Sant'Andrea Hospital, "Sapienza" University of Rome, Rome, Italy.

Background: We aimed to validate Imamura nomogram for prediction of stone free rate in patients undergoing ureterolithotripsy.

Methods: From January 2013 to June 2016, patients undergoing laser semi-rigid ureterolithotripsy were prospectively enrolled at our centre. All patients were preoperatively assessed with clinical history, blood samples, uranalysis and non-contrast enhanced CT. Read More

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December 2018

A Life-Saving Palsy: Hereditary Neuropathy with Liability to Pressure Palsies (HNPP) Presenting As Hand Weakness during Cardiopulmonary Resuscitation (CPR) Training

Ir Med J 2018 09 10;111(8):808. Epub 2018 Sep 10.

Department of Clinical Neurophysiology, St. Vincent’s University Hospital, Elm Park, Dublin 4, Ireland.

Aim To describe a case of acute and transient hand weakness that developed during cardiopulmonary resuscitation (CPR) training. Hereditary neuropathy with liability to pressure palsies (HNPP) should be considered in patients with recurrent, painless motor or sensory neuropathies at sites of peripheral nerve compression. Methods Nerve conduction studies confirmed neuropraxia of the distal ulnar nerve with a mild background demyelinating peripheral neuropathy. Read More

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September 2018

Surgery for Locally Advanced GIT Cancers Has Potentially Good Postoperative Outcomes in a Tertiary Hospital.

J Gastrointest Cancer 2018 Dec 14. Epub 2018 Dec 14.

Department of Medical Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Background: Adhesions and infiltration into adjacent tissues are present in about 12% of gastrointestinal (GIT) cancers. These adhesions have high potential risk of malignancy. Free resection margin is a predictor of good survival in such patients. Read More

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December 2018

Vaginoplasty and creating labia minora in children with disorders of sex development.

Int Urol Nephrol 2018 Dec 13. Epub 2018 Dec 13.

Department of Visceral Surgery, Faculty of Medicine, Children's Hospital Canastel, University of Oran, Oran, Algeria.

Purpose: To report current results of vaginoplasty using the mucosa of the prepuce, and creating labia minora by penile skin in children with disorders of sex development (DSD).

Methods: In 10 years, we have performed 22 vaginoplasties using the described technique of vaginoplasty, 21 patients with 46, XX DSD and 1 ovotesticular DSD. The assessment of the results of this technique of vaginoplasty was undertaken in several stages: (a) The evaluation of the cosmetic result. Read More

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December 2018

Single-center experience using the 3MAX or 4MAX reperfusion catheter for the treatment of acute ischemic stroke with distal arterial occlusions in patients not eligible for intravenous fibrinolysis.

Radiol Med 2018 Dec 13. Epub 2018 Dec 13.

Unit of Neuroimaging and Neurointervention (NINT), Department of Neurological and Sensorineural Sciences, Azienda Ospedaliera Universitaria Senese, Policlinico "Santa Maria alle Scotte", Viale M. Bracci 2, Siena, Italy.

Background: In acute stroke, distal cerebrovascular occlusions can be linked to severe clinical symptoms, and treatment by mechanical thrombectomy may have an important clinical impact. When intravenous fibrinolytic therapy is firmly contraindicated, it remains the only treatment option.

Methods: A total of 42 patients with isolated distal arterial occlusions and absolute contraindication for intravenous fibrinolytic therapy were retrospectively included. Read More

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December 2018

Opening-wedge osteotomies of the distal femur: minor advantages for a biplanar compared to a uniplanar technique.

Knee Surg Sports Traumatol Arthrosc 2018 Dec 13. Epub 2018 Dec 13.

Institute of Biomechanics, Paracelsus Medical University Salzburg, Strubergasse 21, 5020, Salzburg, Austria.

Purpose: Valgus malalignment of the distal femur may be treated with corrective osteotomy. The purpose of this study was to compare the primary stability of a lateral opening-wedge osteotomy (LOWO) using a uniplanar compared to a biplanar technique. A study was carried out to test both surgeries, with both an intact medial cortex and with a deliberate attached cut of the medial cortex simulating a fracture. Read More

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December 2018