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Psychogeriatrics 2019 Apr 17. Epub 2019 Apr 17.

Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.

Differentiating posterior cortical atrophy (PCA) from other diseases can be difficult and time-consuming, and there is a particularly high possibility of misdiagnosis when psychiatrists diagnose complaints related to visual perception. Here, a case of PCA involving prominent visual perceptual disorders is reported; PCA was difficult to distinguish from psychogenic disturbance of vision in this case. For a year, a 59-year-old woman had had visual perceptual disorders, including a distorted view and prosopagnosia. Read More

Indian J Psychiatry 2019 Mar-Apr;61(2):177-183

Department of Psychiatry and Drug De-addiction, Centre of Excellence in Mental Health, Post Graduate Institute of Medical Education and Research-Dr Ram Manohar Lohia Hospital, New Delhi, India.

Background: Dissociative disorders are theorized to be caused by extremely stressful situations, including abuse, kidnapping, incest, rape, and other threats of death. Such childhood experiences alter one's cognitive style as well as one's ability to deal with adverse situations. It is important to understand how cognitive style influences the relationship between parental style and resilience to help in the management. Read More

Australas Psychiatry 2019 Apr 16:1039856219839480. Epub 2019 Apr 16.

Senior Clinical Lecturer, Department of Psychiatry, University of Sydney, Sydney, NSW, and; Senior Staff Specialist, Mood Disorders Unit, Cumberland Hospital, Westmead, NSW, and; Consultant Psychiatrist, St John of God Health, North Richmond, NSW, Australia.

Objectives: Dissociative identity disorder in relation to brain injury has only rarely been reported in literature. This case report, which illustrates a de novo onset of dissociative identity for the first time in an elderly man who had a left parietal haematoma, adds to this scant literature base and supports an integrative view of bridging the dichotomy between organic and functional to explain complex psychiatric phenomena.

Methods: It is a single case report collected through serial semi-structured interviews of the patient and his family over a 12-week period. Read More

Cogn Neuropsychiatry 2019 Apr 16:1-17. Epub 2019 Apr 16.

a Department of Psychology , Goldsmiths, University of London , London , UK.

Introduction: Hypnotic suggestibility is elevated in the dissociative disorders but the relationship between dissociative tendencies and suggestibility in the general population seems to be constrained by additional factors. The diathesis-stress (DS) model stipulates that suggestibility interacts with trauma exposure to augment the propensity for dissociative states whereas the dual pathway to suggestibility (DPS) model proposes two developmental routes involving either dissociation preceded by trauma, or a healthy cognitive profile characterised by superior imagination.

Methods: This study sought to discriminate between these partially competing accounts and further considered the moderating role of anxious attachment. Read More

Neuroimage Clin 2019 Apr 2;23:101807. Epub 2019 Apr 2.

Clienia Littenheid AG, Hospital for Psychiatry and Psychotherapy, Littenheid, Switzerland; Department of Psychiatry, Psychotherapy, and Psychosomatics, University Hospitals and University of Halle (Saale), Halle, Germany.

Objectives: We investigated whether patients with complex interpersonal trauma engage neural networks that are commonly activated during cognitive reappraisal and responding naturally to affect-laden images. In this naturalistic study, we examined whether trauma treatment not only reduces symptoms but also changes neural networks involved in emotional control.

Methods: Before and after eight weeks of phase-oriented inpatient trauma treatment, patients (n = 28) with complex posttraumatic stress disorder (cPTSD) and complex dissociative disorders (CDD) performed a cognitive reappraisal task while electroencephalography (EEG) was registered. Read More

Rev Prat 2019 Feb;69(2):214-218

Centre hospitalier universitaire de Nancy, unité d'épileptologie, Nancy, France.

Non-epileptic psychogenic seizures: a renewal approach of conversion disorders. Psychogenic non-epileptic seizures (PNES) are characterized by a paroxystic modification of behaviour or consciousness that resemble to an epileptic seizure. They are classified as dissociative or somatoform disorders. Read More

J Nurs Scholarsh 2019 Apr 12. Epub 2019 Apr 12.

Department of Nursing, California State University Northridge, College of Health and Human Development, Department of Nursing, Northridge, CA,, USA.

Purpose: The purpose of this study was to uncover and describe the barriers to education as experienced by Syrian refugee girls in the Za'atri Syrian Refugee Camp in Jordan.

Design: A qualitative nonexperimental design utilizing focus group discussions (FGDs), individual interviews, and participant and nonparticipant observation was used for this study. Four FGDs were facilitated in three dropout education centers (nonformal school) in the Za'atri Syrian Refugee Camp. Read More

Soc Work Health Care 2019 Apr 8:1-15. Epub 2019 Apr 8.

a Department of Applied Social Sciences , The Hong Kong Polytechnic University , Hung Hom , Hong Kong.

Depression is a serious public health issue, but not all patients with depression respond well to pharmaceutical treatments. Some scholars suggested that dissociation could be a marker indicating the types of patients with depression that may benefit more from psychosocial interventions than from pharmaceutical treatments. This study explored the possibility to differentiate dissociative depression and nondissociative depression in a clinical sample (N = 68) in the Chinese context, and discusses the potential implications for treatment considerations. Read More

J Clin Psychopharmacol 2019 May/Jun;39(3):226-237

Relmada Therapeutics, Inc, New York, NY.

Purpose/background: N-methyl-D-aspartate (NMDA) receptor (NMDAR) antagonists are potential agents for the treatment of several central nervous system disorders including major depressive disorder. Racemic methadone, L-methadone, and D-methadone all bind the NMDAR with an affinity similar to that of established NMDAR antagonists, whereas only L-methadone and racemic methadone bind to opioid receptors with high affinity. Therefore, D-methadone is expected to have no clinically significant opioid effects at therapeutic doses mediated by its NMDAR antagonism. Read More

JAMA Neurol 2019 Apr 1. Epub 2019 Apr 1.

UCB Pharma, Raleigh, North Carolina.

Importance: Limited population-based data are available on antiepileptic drug (AED) treatment patterns in women of childbearing age with epilepsy; the current population risk is not clear.

Objectives: To examine the AED treatment patterns and identify differences in use of valproate sodium and topiramate by comorbidities among women of childbearing age with epilepsy.

Design, Setting, And Participants: A retrospective cohort study used a nationwide commercial database and supplemental Medicare as well as Medicaid insurance claims data to identify 46 767 women with epilepsy aged 15 to 44 years. Read More

Front Psychiatry 2019 15;10:108. Epub 2019 Mar 15.

Centre Fòrum Research Unit, Institut de Neuropsiquiatria i Addiccions, Barcelona, Spain.

Psychological trauma has a strong negative impact on the onset, course and prognosis of substance use disorders (SUD). Few trauma-oriented treatment approaches have been trialed, but preliminary evidence exists of the efficacy of Eye Movement Desensitization and Reprocessing (EMDR) therapy in improving clinical symptoms in SUD patients. To assess if EMDR therapy leads to: (1) reduced substance consumption; (2) an improvement in psychopathological and in trauma-related symptoms; and (3) an improvement in overall functioning. Read More

J Psychosom Res 2019 May 13;120:90-95. Epub 2019 Mar 13.

ToNIC, Toulouse NeuroImaging Centre, Université de Toulouse (Toulouse University), Inserm, UPS, France.

Introduction: Lightning strike victims often suffer repercussions. Although a lightning strike constitutes a severe traumatic event, there is a lack of data about potential psychological sequelae. This is precisely the context in which we assessed the prevalence of Post-Traumatic Stress Disorder (PTSD) and Major Depressive Episode (MDE) in a group of lightning strike victims. Read More

J Nerv Ment Dis 2019 May;207(5):406-409

Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Although children with dissociative disorders (DD) are referred to mental health inpatient units, no research exists to endorse this. We studied the outcomes of patients with DD over a 5-year period on a national inpatient unit for children up to 12 years of age. Demographic, clinical, and satisfaction data were collected and compared with the data of other inpatients not having DD. Read More

J Trauma Dissociation 2019 Mar 29:1-9. Epub 2019 Mar 29.

a Behavioural Science Institute , Radboud University , Nijmegen , The Netherlands.

Although dissociative symptoms are observed in several psychiatric disorders and linked to antisocial behavior and offending, the relation between dissociation and psychopathology or comorbidity has not been consistently investigated in residential youth yet. This brief report documented prevalence and comorbidity rates of several psychiatric disorders and examined their relation to dissociation in residential youth. The study included 100 male adolescents (Mage = 16. Read More

CNS Spectr 2019 Mar 21:1-4. Epub 2019 Mar 21.

Department of Neurosciences,Deutsches Hospital,Buenos Aires,Argentine Republic.

Background: Fibromyalgia (FM) is a chronic pain syndrome with a controversial etiopathogenesis. Patients with FM usually complain of cognitive symptoms, which are described as "fibrofog." These cognitive complaints might be caused partially by dissociative disorders (DD). Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2019;119(2):125-128

Novosibirsk State Medical University, Novosibirsk, Russia.

Current concepts of post-psychotic period rarely include posttraumatic context due to the conventional clinical opinion about psychotic disorders and transformation of the typical posttraumatic stress disorder symptoms. The authors presented the ways of coincidence of dissociative posttraumatic symptoms (dissociative spectra) and psychotic spectra, their reciprocal connection and different variants depending on psychosis dynamic type. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2019;119(2):5-10

National Research Center for Hematology, Moscow, Russia.

Aim: To study psychopathological features of victimity in hemophiliacs.

Material And Methods: Thirty-one men with hemophilia, aged 17-63 years, mean age 33.43±9. Read More

Eur J Psychotraumatol 2019 14;10(1):1571377. Epub 2019 Feb 14.

Department of Clinical Psychology, University of Amsterdam, Amsterdam, the Netherlands.

: A category of disorders frequently associated with a history of trauma are the dissociative disorders, of which Dissociative Identity Disorder (DID) is the most severe and chronic form. DID is associated with high levels of impairment, treatment utilization, and treatment costs, yet systematic research into treatment effects is scarce. Practice-based clinical guidelines advise a phase-based approach which is lengthy and has rather high reported dropout rates. Read More

Neurobiol Dis 2019 Feb 21;127:32-44. Epub 2019 Feb 21.

Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA.

Functional movement disorders (FMDs), known over time as "hysteria", "dissociative", "conversion", "somatoform", "non-organic" and "psychogenic" disorders, are characterized by having a voluntary quality, being modifiable by attention and distraction but perceived by the patient as involuntary. Although a high prevalence of depression and anxiety is observed in these patients, a definitive role of psychiatric disorders in FMDs has not been proven, and many patients do not endorse such manifestations. Stressful events, social influences and minor trauma may precede the onset of FMDs, but their pathogenic mechanisms are unclear. Read More

J Subst Abuse Treat 2019 Apr 4;99:73-79. Epub 2019 Jan 4.

Center for Interdisciplinary Addiction Research, Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. Electronic address:

The dissociative subtype of posttraumatic stress disorder (PTSD) was officially introduced in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). In accordance with this new classification, prior studies using Latent Class Analysis (LCA) empirically identified a subgroup of patients that were characterized by a high severity of dissociative symptoms. Despite the high prevalence of PTSD in patients with substance use disorders (SUD), however, no LCA studies on the dissociative subtype of PTSD exist in this population so far. Read More

Psychiatry Res 2019 01 10;271:702-707. Epub 2018 Dec 10.

Department of Health and Social Sciences, Molde University College, Molde, Norway.

The aim of this study was to explore the roles of pre-earthquake characteristics (age, gender, years of education, history of childhood and recent trauma and trait dissociation), during-the-earthquake state (peritraumatic dissociation) and post-earthquake difficulties (severity of exposure to earthquake) in post-traumatic stress among survivors of the 2017 Iran earthquake. A total number of 127 individuals in Kermanshah and 103 individuals in Sarpol-e Zahab completed and returned a 105-item questionnaire. Among these, 32 (25. Read More

Brain Stimul 2019 Jan 31. Epub 2019 Jan 31.

CHU Lille, Hôpital Fontan, Department of Psychiatry, F-59000, Lille, France; Univ. Lille, CNRS UMR-9193, SCALab - Sciences Cognitives et Sciences Affectives, France; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Introduction: Psychogenic non-epileptic seizures (PNES) are paroxysms of either altered subjective or objective manifestations that may mimic epileptic seizures (ES), without abnormal neuronal epileptiform activity. In this report, we present the case of a 39-year-old woman with PNES and functional movement disorders, who was successfully treated with neuro-guided transcranial direct current stimulation (tDCS).

Methods: We used a PET-guided tDCS approach, as a hypometabolism of the frontal region was revealed by FDG TEP scan. Read More

J Trauma Dissociation 2019 Mar-Apr;20(2):228-241. Epub 2019 Feb 13.

a Department of Psychology , Middlebury College , Middlebury , VT , USA.

Attention in trauma-related disorders has been characterized by both vigilance and avoidance of trauma-related or aversive stimuli. This study used eye-tracking technology to investigate how cumulative trauma, as well as hypervigilance and dissociative symptoms, affected attentional patterns to anticipated negative stimuli and actual negative stimuli. A sample of forty-two trauma participants recruited from the community had a choice about where to look on a computer screen knowing which segments of the screen negative stimuli were likely to appear. Read More

Indian J Psychiatry 2019 Jan;61(Suppl 2):247-253

Psychiatry Unit, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India.

J Clin Sleep Med 2019 Feb 15;15(2):355-357. Epub 2019 Feb 15.

Cleveland Clinic Sleep Disorders Center, Cleveland, Ohio.

Abstract: The most common sleep disorders that can result in injurious or violent behaviors include REM sleep behavioral disorder, sleepwalking, comorbid parasomnias, sleep-related dissociative disorder, and obstructive sleep apnea. Video polysomnography is usually indicated to evaluate recurring sleep-related injury in adults. Only one-third of patients with complex paroxysmal nocturnal events will have one of their habitual events on a single night of in-laboratory video polysomnography, most often those who have prominent, high-frequency motor features. Read More

Arch Gynecol Obstet 2019 Mar 8;299(3):755-763. Epub 2019 Feb 8.

Department of Obstetrics and Gynecology, University of Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.

Purpose: To investigate the real-life epidemiology of mental disorders during pregnancy and their impact on birth outcome in an unselected low-risk population in Germany.

Methods: Claims data of the Techniker Krankenkasse (TK) were analyzed as part of a retrospective observational study over a one-year period from 01/2008 to 12/2008 including 38,174 pregnant women. ICD-10 codes were clustered into four diagnostic groups: depression, anxiety disorders, somatoform/dissociative disorders and acute stress reactions. Read More

J Trauma Dissociation 2019 Mar-Apr;20(2):212-227. Epub 2019 Feb 4.

d University of Michigan , Ann Arbor , Michigan , USA.

The purpose of this study was to explore relationships between maltreatment, posttraumatic stress disorder, and the dissociative subtype of posttraumatic stress disorder among adolescents. This descriptive study used secondary data from the National Child Traumatic Stress Network Core Data Set. A clinical sample of adolescents exposed to potentially traumatizing events ages 12 to 16 was selected (N = 3081) to explore associations between trauma history characteristics, sociodemographic factors, posttraumatic stress disorder, and the dissociative subtype of PTSD which includes depersonalization and derealization. Read More

J Trauma Dissociation 2019 Mar-Apr;20(2):242-257. Epub 2019 Jan 28.

a Center for Psychiatry Südwürttemberg , Ulm University , Ravensburg- Weissenau , Germany.

We analyze the empirical evidence for the association between the occurrence of dissociation and acting as a female sex worker (FSW). The ten screened databases included original research papers looking at the association between various abusive relationships and dissociation. From the initial 5942 records, we screened 554 full-text articles from which eleven studies met the inclusion criteria. Read More

Ideggyogy Sz 2018 Nov;71(11-12):385-392

Sakarya University Research and Training Hospital, Department of Neurology, İstanbul, Turkey.

Background And Purpose: Migraine is a common and often debilitating disorder. Although the existence of a link between migraine and certain psychological features has long been known, data on dissociative experiences in migraine patients is insufficient. The aim of this study was to evaluate the presence of psychoform and somatoform dissociative experiences among migraine patients without aura and to examine their relationship with pain perception and disability. Read More

Psychol Trauma 2018 Dec 27. Epub 2018 Dec 27.

Department of Psychiatry.

Objective: Profiling patients who report early childhood trauma and emotional neglect may be useful for treatment planning. This study attempts to quantify a two-dimensional "trauma-neglect model" (Draijer, 2003) proposed to distinguish clinical profiles in terms of trauma-related, dissociative, and personality pathology.

Method: A sample of patients referred to a trauma program ( = 49) and a personality disorders program ( = 101) was extensively assessed. Read More

Early Interv Psychiatry 2018 Dec 25. Epub 2018 Dec 25.

Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia.

Aim: Increasing evidence suggests that childhood trauma and dissociation are associated with psychotic symptoms and disorders. Significant rates of dissociative disorders and clinical levels of dissociative symptoms are found in chronic schizophrenia. To date, no studies have examined the prevalence of these in a first episode psychosis (FEP) group. Read More

Emerg (Tehran) 2018 2;6(1):e47. Epub 2018 Aug 2.

Department of Epidemiology, Faculty of Health, Iran University of Medical Sciences, Tehran, Iran.

Introduction: About 5% of visits to emergency departments are made up of conversion disorder cases. This study was designed with the aim of comparing the effectiveness of quetiapine and haloperidol in controlling conversion disorder symptoms.

Methods: The present single-blind clinical trial has been performed on patients with conversion disorder (based on the DSM-IV definition) presenting to emergency department of 9-Day Hospital, Torbat Heydariyeh, Iran, from January 2017 until May 2018. Read More

Dialogues Clin Neurosci 2018 09;20(3):229-242

The Trauma Disorders Program, Sheppard Pratt Health System, Maryland, USA; Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Controversy about dissociation and the dissociative disorders (DD) has existed since the beginning of modern psychiatry and psychology. Even among professionals, beliefs about dissociation/DD often are not based on the scientific literature. Multiple lines of evidence support a powerful relationship between dissociation/DD and psychological trauma, especially cumulative and/or early life trauma. Read More

Eat Weight Disord 2019 Apr 18;24(2):329-338. Epub 2018 Dec 18.

Meadows Behavioral Healthcare, Wickenburg, AZ, USA.

Background: Learning about the life stories of patients who have experienced a severe eating disorder (ED), but also traumas that led to PTSD, dissociative disorders, and other comorbidities, has great value to clinicians in their efforts to deliver trauma-informed care (TIC). Many investigators have been researching and writing about these issues for years, and strong scientific evidence has emerged, indicating that trauma is a significant risk factor for the development of EDs, particularly in its bulimic forms.

Purpose: Peer-reviewed literature contains scarce input from people with "lived experiences". Read More

Front Psychol 2018 4;9:2390. Epub 2018 Dec 4.

Child Neuropsychiatry Unit, Mother and Child Department, Del Ponte Hospital, Azienda Socio Sanitaria Territoriale (ASST) Sette Laghi, Varese, Italy.

The direct and long-term effects of children's exposure to traumatic events can be seen in a complex continuum, based first of all on the type of trauma. Children's reactions to trauma may have different manifestations from the clinical picture of the PTSD, exhibiting dissociative, somatic, depressive or anxiety symptoms, and/or disruptiveness. we conducted a cross-sectional study in a psychiatric patients sample to determine the extent to which complex trauma history is associated with disease-related characteristics (diagnosis, dissociative symptoms, somatic symptomatology, impairment degree). Read More

Transl Psychiatry 2018 12 14;8(1):280. Epub 2018 Dec 14.

Statistical Genomics and Data Analysis Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Growing evidence suggests that the glutamatergic modulator ketamine has rapid antidepressant effects in treatment-resistant depressed subjects. The anticholinergic agent scopolamine has also shown promise as a rapid-acting antidepressant. This study applied genome-wide markers to investigate the role of genetic variants in predicting acute antidepressant response to both agents. Read More

Int J Neuropsychopharmacol 2019 Mar;22(3):247-259

Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, McCormick School of Engineering and Applied Sciences, Northwestern University, Evanston, Illinois.

Background: Modulation of glutamatergic synaptic transmission by N-methyl-D-aspartate receptors can produce rapid and sustained antidepressant effects. Rapastinel (GLYX-13), initially described as a N-methyl-D-aspartate receptor partial glycine site agonist, exhibits rapid antidepressant effect in rodents without the accompanying dissociative effects of N-methyl-D-aspartate receptor antagonists.

Methods: The relationship between rapastinel's in vitro N-methyl-D-aspartate receptor pharmacology and antidepressant efficacy was determined by brain microdialysis and subsequent pharmacological characterization of therapeutic rapastinel concentrations in N-methyl-D-aspartate receptor-specific radioligand displacement, calcium mobilization, and medial prefrontal cortex electrophysiology assays. Read More

Ind Health 2019 Feb 7;57(1):79-83. Epub 2018 Dec 7.

Department of Preventive Medicine and Community Health, School of Medicine, University of Occupational and Environmental Health, Japan.

This study used health insurance claims data to examine the relationship between the length of sick leave and treatment administered to employees who received middle- to long-term accident and sickness benefits for ≥91 d due to mood disorders, anxiety, and dissociative, stress-related, somatoform and other nonpsychotic mental disorders. Employees who received psychotherapy had significantly shorter leaves of absence over one year compared to those that did not. Treatment with psychotropic drugs was significantly higher among those on leave for ≤365 d than those on leave for ≥366 d. Read More

Paediatr Drugs 2019 Feb;21(1):25-31

Mother and Child Health, and Radiology Department, Cádiz University, Cadiz, Spain.

Background: Upper gastrointestinal endoscopies (UGEs) performed under ketamine sedation may increase the risk of respiratory adverse events (RAEs) due to pharyngeal stimulation. Topical lidocaine prevents general anesthesia-induced laryngospasm.

Objective: Our objective was to determine whether topical lidocaine may reduce the incidence of RAEs induced by pharyngeal stimulation in UGEs performed on children sedated with ketamine. Read More

Prog Brain Res 2018 25;242:121-158. Epub 2018 Oct 25.

Faculty of Health Sciences, University of the Witwatersrand Medical School, Johannesburg, South Africa.

Ibogaine is a plant-derived alkaloid and dissociative psychedelic that demonstrates anti-addictive properties with several substances of abuse, including alcohol. 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring psychedelic known to occasion potent mystical-type experiences and also demonstrates anti-addictive properties. The potential therapeutic effects of both compounds in treating alcohol use disorder require further investigation and there are no published human neuroimaging findings of either treatment to date. Read More

Eur J Psychotraumatol 2018 14;9(1):1544025. Epub 2018 Nov 14.

National Advisory Unit on Substance Use Disorder Treatment, Oslo University Hospital, Oslo, Norway.

: The four-dimensional ('4-D') model has been proposed as a theoretical framework to understand and delineate trauma-related dissociative experiences, categorizing symptoms into trauma-related altered states of consciousness (TRASC) and normal waking consciousness (NWC), which occur along four dimensions: time, thought, body and emotion. : The main aim of the present study was to evaluate the validity of this model in patients with post-traumatic stress disorder (PTSD), with and without comorbid dissociative disorders. : The predictions of the 4-D model were tested in 142 patients with PTSD, with ( = 46) and without ( = 96) comorbid dissociative disorders. Read More

Aten Primaria 2018 Nov 16. Epub 2018 Nov 16.

Unitat de Suport a la Recerca Costa de Ponent, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Cornellà de Llobregat, Spain; Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain. Electronic address:

Objective: To study the relationship between maternal affective disorders (AD) before and during pregnancy, and pre-term birth.

Design: Retrospective observational study.

Location: Sexual and reproductive health units at the Institut Català de la Salut (ICS) in Catalonia, Spain. Read More

J Trauma Dissociation 2019 Mar-Apr;20(2):140-164. Epub 2018 Nov 16.

a Division of Depression and Anxiety Disorders , McLean Hospital , Belmont , MA , USA.

Failing to recognize one's mirror image can signal an abnormality in one's sense of self. In dissociative identity disorder (DID), individuals often report that their mirror image can feel unfamiliar or distorted. They also experience some of their own thoughts, emotions, and bodily sensations as if they are nonautobiographical and sometimes as if instead, they belong to someone else. Read More

West J Emerg Med 2018 Nov 10;19(6):952-960. Epub 2018 Sep 10.

Lewis Gale Medical Center, Department of Emergency Medicine, Salem, Virginia.

Introduction: Patients frequently present to the emergency department (ED) with migraine headaches. Although low-dose ketamine demonstrates analgesic efficacy for acute pain complaints in the ED, headaches have historically been excluded from these trials. This study evaluates the efficacy and safety of low-dose ketamine for treatment of acute migraine in the ED. Read More

Curr Psychiatry Rep 2018 Nov 7;20(12):118. Epub 2018 Nov 7.

Stanford University School of Medicine, Stanford, CA, USA.

Dissociative experiences have been associated with increased disease severity, chronicity, and, in some cases, reduced treatment response across trauma-related and other psychiatric disorders. A better understanding of the neurobiological mechanisms through which dissociative experiences occur may assist in identifying novel pharmacological and non-pharmacological treatment approaches. Here, we review emerging work on the dissociative subtype of posttraumatic stress disorder (PTSD), and other trauma-related disorders providing evidence for two related overarching neurobiological models of dissociation, the defense cascade model of dissociation and Mobb's threat detection model. Read More

Int J Environ Res Public Health 2018 10 31;15(11). Epub 2018 Oct 31.

Institute for Sex Research and Forensic Psychiatry, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Organized and ritual child sexual abuse (ORA) is often rooted in the child's own family. Empirical evidence on possible associations between ORA and trauma-related symptoms in those who report this kind of extreme and prolonged violence is rare. The aim of our study was to explore socio-demographic and clinical characteristics of the individuals reporting ORA experiences, and to investigate protective as well as promotive factors in the link between ORA and trauma-related symptom severity. Read More

Behav Brain Res 2019 02 22;359:165-171. Epub 2018 Oct 22.

Memory and Cognition Studies Laboratory, Department of Psychology, Federal University of Paraíba, João Pessoa, PB, Brazil; Laboratory of Psychopharmacology, Federal University of Paraíba, João Pessoa, PB, Brazil. Electronic address:

Episodic-like memory refers to integration of where and when a certain event (what) happened. The glutamatergic neurotransmission, particularly AMPA and NMDA receptors, in the dorsal hippocampus mediates episodic recall. Ketamine is a non-competitive NMDA antagonist with effect on cognitive performance and plasticity. Read More