12,342 results match your criteria Dissociative Disorders


Dissociative states in borderline personality disorder and their relationships to psychotropic medication.

Neuropsychiatr Dis Treat 2018 23;14:3253-3257. Epub 2018 Nov 23.

Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry and UHSL, 1st Faculty of Medicine, Charles University, Prague, Czech Republic,

Background: According to recent data, dissociation may play an important role in borderline personality disorder (BPD), nevertheless specific influences of psychotropic medication on dissociative symptoms in BPD and their therapeutic indications are largely unknown. The purpose of this study was to assess relationships of dissociative symptoms in BPD patients with levels of psychotropic medication and compare these results with a subgroup of patients with schizophrenia.

Materials And Methods: In this study, we investigated 52 BPD patients and compared the results with a control group of 36 schizophrenia patients. Read More

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November 2018

Relationship between treatment and period of absence among employees on sick leave due to mental disease.

Ind Health 2018 Dec 7. Epub 2018 Dec 7.

Department of Preventive Medicine and Community Health, School of Medicine, University of Occupational and Environmental Health, Japan.

This study used health insurance claims data to examine the relationship between the length of sick leave and treatment administered to employees who received middle- to long-term accident and sickness benefits for ≥91 d due to mood disorders, anxiety, and dissociative, stress-related, somatoform and other nonpsychotic mental disorders. Employees who received psychotherapy had significantly shorter leaves of absence over one year compared to those that did not. Treatment with psychotropic drugs was significantly higher among those on leave for ≤365 d than those on leave for ≥366 d. Read More

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December 2018

Subchronic ketamine alters behaviour, metabolic indices and brain morphology in adolescent rats: involvement of oxidative stress, glutamate toxicity and caspase-3-mediated apoptosis.

J Chem Neuroanat 2018 Dec 7. Epub 2018 Dec 7.

Department of Medical Pharmacology and Therapeutics, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria. Electronic address:

Ketamine is a dissociative anaesthetic agent whose recreational use amongst adolescents and young adults is reaching epidemic proportions in a number of countries. While animal studies have examined the long-term detrimental effects of early-life ketamine exposure, there is a paucity of information on the immediate effects of ketamine following subchronic administration in the adolescence period. Adolescent rats were assigned into four groups of 10 animals each, administered intraperitoneal (i. Read More

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December 2018

Electron-Induced Formation of Ethyl Methyl Ether in Condensed Mixtures of Methanol and Ethylene.

J Phys Chem A 2018 Dec 11. Epub 2018 Dec 11.

Electron-induced reactions in condensed mixtures of ethylene (CH) and methanol (CHOH) lead to the formation of ethyl methyl ether (EME, CHOCH) as shown by post-irradiation thermal desorption spectrometry (TDS). In contrast to the electron-induced reaction between water (HO) and CH, product formation as a consequence of proton transfer following electron attachment (EA) to CH is not observed in the analogous reaction between CHOH and CH. However, a resonant process centered around 5. Read More

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December 2018

O Kinetic Isotope Effects Reveal an Associative Transition State for Phosphite Dehydrogenase Catalyzed Phosphoryl Transfer.

J Am Chem Soc 2018 Dec 7. Epub 2018 Dec 7.

Phosphite dehydrogenase (PTDH) catalyzes an unusual phosphoryl transfer reaction in which a water nucleophile displaces hydride from phosphite. Despite extensive effort, it remains unclear whether PTDH catalysis proceeds via an associative or dissociative mechanism. Here, primary H and secondary O kinetic isotope effects (KIEs) were determined and used in combination with computational chemistry to characterize the transition state catalyzed by a thermostable variant of PTDH (17X-PTDH). Read More

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December 2018

Competitive Ligand Exchange and Dissociation in Ru Indenyl Complexes.

Inorg Chem 2018 Dec 11. Epub 2018 Dec 11.

Department of Chemistry , University of Victoria , P. O. Box 1700, STN CSC , Victoria , British Columbia V8W 2Y2 , Canada.

Kinetic profiles obtained from monitoring the solution-phase substitution chemistry of [Ru(η-indenyl)(NCPh)(PPh)] (1) by both electrospray ionization mass spectrometry and P{H} NMR are essentially identical, despite an enormous difference in sample concentrations for these complementary techniques. These studies demonstrate dissociative substitution of the NCPh ligand in 1. Competition experiments using different secondary phosphine reagents provide a ranking of phosphine donor abilities at this relatively crowded half-sandwich complex: PEtH > PPhH ≫ PCyH. Read More

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December 2018

Dissociative effects of dorsomedial striatum D1 and D2 receptor antagonism in the regulation of anxiety and learned approach-avoidance conflict decision-making.

Neuropharmacology 2018 Nov 30. Epub 2018 Nov 30.

Department of Psychology, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON, M1C 1A4, Canada. Electronic address:

The dorsal striatum is traditionally known for its role in sensorimotor integration. However, the dorsomedial striatum (DMS) has also been implicated in cost-benefit conflict processing, a role more readily attributed to the ventral striatum (VS), as a site of limbic-motor integration. We recently showed that dopaminergic D1 (D1R) and D2 receptors (D2R) in the VS exert dissociable control over cue-elicited approach-avoidance decision-making, in the presence of conflicting motivational stimuli. Read More

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November 2018

Dissociative state: Returned traveller with a high fever and low heart rate.

J Paediatr Child Health 2018 Dec;54(12):1395-1396

Infectious Diseases Unit, Department of General Medicine, Royal Children's Hospital Melbourne, Melbourne, Victoria, Australia.

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December 2018
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Dissociative state: Returned traveller with a high fever and low heart rate.

J Paediatr Child Health 2018 Dec;54(12):1392

Infectious Diseases Unit, Department of General Medicine, Royal Children's Hospital Melbourne, Melbourne, Victoria, Australia.

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December 2018
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Biased emotional attention in patients with dental phobia.

Eur J Neurosci 2018 Dec 1. Epub 2018 Dec 1.

Institute for Biomagnetism and Biosignal Analysis, University of Muenster, D-48149, Muenster, Germany.

Biased motivated attention towards phobia-relevant pictures is a typical finding in specific phobia. In the visual system, the allocation of motivated attention is indexed by two event-related potential components - the Early Posterior Negativity and the Late Positive Potential. Enhanced Early Posterior Negativity and Late Positive Potential amplitudes are reliably observed in specific phobia such as, for instance, snake, spider or blood-injection-injury phobia and to some extent also in dental phobia. Read More

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December 2018
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Phobia of the Supernatural: A Distinct but Poorly Recognized Specific Phobia With an Adverse Impact on Daily Living.

Front Psychiatry 2018 16;9:590. Epub 2018 Nov 16.

The D'Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil.

The psychological and psychiatric literature has seldom appreciated the clinical fact that fears of ghosts and kindred supernatural worries may be a cause of intense discomfort, poor sleep, and socio-occupational impairment. In the present article, this claim is illustrated by the clinical features of six patients who developed intense anxiety when they had to sleep alone at night. The fears were first noticed in childhood and persisted into adolescence and adulthood. Read More

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November 2018

Traumatic experiences and dissociation in patients with conversion disorder.

J Pak Med Assoc 2018 Dec;68(12):1776-1781

University of Central Punjab, Lahore.

Objective: To explore the association between childhood trauma and dissociation in patients of conversion disorder.

Methods: The cross-sectional study was conducted in Lahore, Pakistan, from April to December 2016, and comprised female patients aged 18-40 years diagnosed with conversion disorder at three major public hospitals of the city. Urdu version of symptom checklist for conversion disorder, the dissociative experiences scale and traumatic experiences checklist were used to measure study variables. Read More

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December 2018

Enhanced fear memories and brain glucose metabolism (F-FDG-PET) following sub-anesthetic intravenous ketamine infusion in Sprague-Dawley rats.

Transl Psychiatry 2018 Nov 30;8(1):263. Epub 2018 Nov 30.

Daniel K. Inouye Graduate School of Nursing, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA.

Ketamine is a multimodal dissociative anesthetic, which provides powerful analgesia for victims with traumatic injury. However, the impact of ketamine administration in the peri-trauma period on the development of post-traumatic stress disorder (PTSD) remains controversial. Moreover, there is a major gap between preclinical and clinical studies because they utilize different doses and routes of ketamine administration. Read More

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November 2018

Electron attachment to hexafluoropropylene oxide (HFPO).

J Chem Phys 2018 Nov;149(20):204305

J. Heyrovský Institute of Physical Chemistry, Czech Academy of Sciences, Dolejškova 3, 18223 Prague, Czech Republic.

We probe the electron attachment in hexafluoropropylene oxide (HFPO), CFO, a gas widely used in plasma technologies. We determine the absolute electron attachment cross section using two completely different experimental approaches: (i) a crossed-beam experiment at single collision conditions (local pressures of 5 × 10 mbar) and (ii) a pulsed Townsend experiment at pressures of 20-100 mbar. In the latter method, the cross sections are unfolded from the electron attachment rate coefficients. Read More

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November 2018

Low-Energy Photoelectron Spectrum and Dissociative Photoionization of the Smallest Amides: Formamide and Acetamide.

J Phys Chem A 2018 Dec 5. Epub 2018 Dec 5.

The threshold photoelectron spectrum and low-energy dissociative photoionization processes of formamide and acetamide were studied using photoelectron photoion coincidence spectroscopy and vacuum ultraviolet synchrotron radiation. Ab initio calculations and Franck-Condon simulations helped us assign the main vibrational progressions in the spectra and enabled the first conclusive assignment of the first electronically excited states. The adiabatic ionization energies to the X and A states of formamide (10. Read More

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December 2018

The Connection between Resonances and Bound States in the Presence of a Coulomb Potential.

J Phys Chem A 2018 Dec 4. Epub 2018 Dec 4.

The connection between resonant metastable states and bound states with changing potential strength in the presence of a Coulomb potential is fundamentally different from the case of short-range potentials. This phenomenon is central to the physics of dissociative recombination of electrons with molecular cations. Here, it is verified computationally that there is no direct connection between the resonance pole of the S-matrix and any pole in the bound state spectrum. Read More

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December 2018

Microscopic Insight into Electron-Induced Dissociation of Aromatic Molecules on Ice.

Phys Rev Lett 2018 Nov;121(20):206001

Physical Chemistry I, Ruhr-Universität Bochum, Universitätsstr. 150, D-44801 Bochum, Germany.

We use scanning tunneling microscopy, photoelectron spectroscopy, and ab initio calculations to investigate the electron-induced dissociation of halogenated benzene molecules adsorbed on ice. Dissociation of halobenzene is triggered by delocalized excess electrons attaching to the π^{*} orbitals of the halobenzenes from where they are transferred to σ^{*} orbitals. The latter orbitals provide a dissociative potential surface. Read More

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November 2018
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Oxygen Electrocatalysis at Mn-O-C Hybrid Heterojunction: An Electronic Synergy or a Cooperative Catalysis?

ACS Appl Mater Interfaces 2018 Nov 30. Epub 2018 Nov 30.

The interface at metal oxide-carbon hybrid heterojunction is the source to 'synergistic effect' in catalysis. Understanding the structure-function property is key for designing more advanced catalyst-support systems. Using a model MnIII-Ox single-layer catalyst on carbon, we herein report a full elucidation to the catalytic synergism at hybrid heterojunction in the oxygen reduction reaction (ORR). Read More

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November 2018
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Observer memories may not be for everyone.

Memory 2018 Nov 29:1-13. Epub 2018 Nov 29.

b Department of Psychiatry , Columbia University , New York , NY ,  USA.

Six studies explored the preponderance of people who experience third-person perspective observer memories during autobiographical memory retrieval. The concept of first-person field versus observer memories has been extensively used in the areas of cognitive, social, and clinical psychology. An implicit assumption is the idea that most people use both of these perspectives. Read More

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November 2018
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Delusion, possession and religion.

Nord J Psychiatry 2018 Nov 29:1-3. Epub 2018 Nov 29.

b Department of Psychosis Studies , King's College , London , UK.

Background: Religion and psychiatry may be both considered to be two different ways of explaining the unknown, of responding to questions about the meaning of life, and of bringing healing.

Aims: To discuss the border between religion and psychiatry.

Method: This lecture explores the interface between religion and psychiatry and discusses the border between soul and mind. Read More

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November 2018
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Dissociative Ionization and Coulomb Explosion of Molecular Bromocyclopropane in an Intense Femtosecond Laser Field.

Molecules 2018 Nov 27;23(12). Epub 2018 Nov 27.

State Key Laboratory of Precision Spectroscopy, School of Physics and Materials Science, East China Normal University, Shanghai 200062, China.

The dissociative ionization and Coulomb explosion of molecular bromocyclopropane (BCP) has been experimentally investigated by time-of-flight mass spectrum and dc-slice imaging technology. The sliced 2D images, kinetic energy releases and angular distributions of the fragment ions are obtained under the intense femtosecond laser fields (8.0 × 10⁻2. Read More

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November 2018
3 Reads

Directly converting syngas to linear α-olefins over core-shell Fe3O4@MnO2 catalysts.

ACS Appl Mater Interfaces 2018 Nov 28. Epub 2018 Nov 28.

Converting syngas to value-added chemicals via Fischer-Tropsch synthesis (FTS) has attracted much attention, whereas the direct hydrogenation of CO to heavy olefins, especially linear α-olefins (LAOs), remains a challenge. In this study, we designed a core-shell Fe3O4@MnO2 catalyst to realize the direct conversion of syngas to LAOs with high efficiency. This catalyst exhibited an enhanced selectivity of 79. Read More

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November 2018

Insight and Dissociation in Lucid Dreaming and Psychosis.

Front Psychol 2018 12;9:2164. Epub 2018 Nov 12.

Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.

Dreams and psychosis share several important features regarding symptoms and underlying neurobiology, which is helpful in constructing a testable model of, for example, schizophrenia and delirium. The purpose of the present communication is to discuss two major concepts in dreaming and psychosis that have received much attention in the recent literature: insight and dissociation. Both phenomena are considered functions of higher order consciousness because they involve metacognition in the form of reflective thought and attempted control of negative emotional impact. Read More

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November 2018
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Locating Exceptional Points on Multidimensional Complex-Valued Potential Energy Surfaces.

J Phys Chem Lett 2018 Nov 27. Epub 2018 Nov 27.

We present a method for locating non-Hermitian degeneracies, called exceptional points (EPs), and minimum-energy EPs between molecular resonances using the complex absorbing potential equation-of-motion coupled cluster (CAP-EOM-CC) method. EPs are the complex-valued analogue of conical intersections (CIs) and have a similar impact on nonadiabatic processes between resonances as CIs have on non-radiative transitions between bound states. The use of analytic gradients enables applications to multidimensional problems. Read More

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November 2018
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Self-Experiments with Psychoactive Substances: A Historical Perspective.

Handb Exp Pharmacol 2018 Nov 27. Epub 2018 Nov 27.

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK.

The purpose of this chapter is to highlight the rich tradition of self-experiments (SEs) with psychoactive substances carried out by scientists and therapists for more than a century. Scientifically inspired controlled SEs dominated until the end of the twentieth century, when ethical requirements minimized controlled SEs and "wild" SEs expanded particularly with the emergence of new psychoactive substances. The review focuses on laughing gas (nitrous oxide), cannabis, cocaine, hallucinogens, entactogens, and dissociative hallucinogens. Read More

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November 2018
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Copper ion-assisted gold nanoparticle aggregates for electrochemical signal amplification of lipopolysaccharide sensing.

Biosens Bioelectron 2018 Nov 16;126:529-534. Epub 2018 Nov 16.

Key Laboratory for Colloid and Interface Chemistry of State Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China. Electronic address:

A signal amplification electrochemical aptasensor for ultrasensitive detection of lipopolysaccharide (LPS) was fabricated. The sensor was constructed with a probe of LPS aptamer and a copper ions-mediated gold nanoparticles aggregate (Cu/Au NA) as a signal amplification material. The Cu/Au NAs comprising copper ions (Cu) and L-cysteine modified AuNPs were fabricated by a self-assembly process. Read More

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November 2018
4 Reads

Metabolites to parent 3-MeO-PCP ratio in human urine collected in two fatal cases.

J Anal Toxicol 2018 Nov 22. Epub 2018 Nov 22.

Institut de Médecine Légale, Université de Strasbourg, 11 rue Humann, Strasbourg, France.

In this article, two fatal cases related to the use of 3-methoxyphencyclidine (3-MeO-PCP) are described. This compound is a new psychoactive substance that belongs to the phencyclidine family. In the recent period, this dissociative drug has gained interest because of its proposal as a legally available alternative to phencyclidine in some countries. Read More

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November 2018
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A case report SPECT study and theoretical rationale for the sequential administration of ibogaine and 5-MeO-DMT in the treatment of alcohol use disorder.

Prog Brain Res 2018 25;242:121-158. Epub 2018 Oct 25.

Faculty of Health Sciences, University of the Witwatersrand Medical School, Johannesburg, South Africa.

Ibogaine is a plant-derived alkaloid and dissociative psychedelic that demonstrates anti-addictive properties with several substances of abuse, including alcohol. 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring psychedelic known to occasion potent mystical-type experiences and also demonstrates anti-addictive properties. The potential therapeutic effects of both compounds in treating alcohol use disorder require further investigation and there are no published human neuroimaging findings of either treatment to date. Read More

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October 2018
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A DFT Screening of M-HKUST-1 MOFs for Nitrogen-Containing Compounds Adsorption.

Nanomaterials (Basel) 2018 Nov 20;8(11). Epub 2018 Nov 20.

School of Material Engineering, Shanghai University of Engineering Science, 333 Longteng Road, Songjiang District, Shanghai 201620, China.

To develop promising adsorbent candidates for adsorptive denitrogenation, we screened the adsorption of NO, NO₂, and NH₃ in 19 M-HKUST-1 (M = Be, Fe, Ni, Cr, Co, Cu, V, Zn, Mo, Mn, W, Sn, Ti, Cd, Mg, Sc, Ca, Sr, and Ba) systematically using first-principle calculations. Of these, four variants of M-HKUST-1 (M = Ni, Co, V, and Sc) yield more negative adsorption Gibbs free energy ΔG than the original Cu-HKUST-1 for three adsorbates, suggesting stronger adsorbate binding. Ti-HKUST-1, Sc-HKUST-1, and Be-HKUST-1 are predicted to have the largest NO, NO₂, and NH₃ adsorption energies within the screened M-HKUST-1 series, respectively. Read More

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November 2018
5 Reads

Bonds Voyage! A Dissociative Model of TCR-CD3 Triggering Is Proposed.

Immunity 2018 Nov;49(5):786-788

Department of Immunobiology, The University of Arizona College of Medicine, Tucson, AZ 85724, USA; The BIO-5 Institute, The University of Arizona College of Medicine, Tucson, AZ 85724, USA; The Arizona Center on Aging, The University of Arizona College of Medicine, Tucson, AZ 85724, USA; The University of Arizona Cancer Center, The University of Arizona College of Medicine, Tucson, AZ 85724, USA. Electronic address:

How the T cell receptor (TCR)-CD3 complex activates T cells is debated. In this issue of Immunity, Brazin et al. (2018) propose that TCR engagement under force releases the CD3 signaling modules to disperse and adopt signaling active states. Read More

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November 2018
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Trauma-related altered states of consciousness in post-traumatic stress disorder patients with or without comorbid dissociative disorders.

Eur J Psychotraumatol 2018 14;9(1):1544025. Epub 2018 Nov 14.

National Advisory Unit on Substance Use Disorder Treatment, Oslo University Hospital, Oslo, Norway.

: The four-dimensional ('4-D') model has been proposed as a theoretical framework to understand and delineate trauma-related dissociative experiences, categorizing symptoms into trauma-related altered states of consciousness (TRASC) and normal waking consciousness (NWC), which occur along four dimensions: time, thought, body and emotion. : The main aim of the present study was to evaluate the validity of this model in patients with post-traumatic stress disorder (PTSD), with and without comorbid dissociative disorders. : The predictions of the 4-D model were tested in 142 patients with PTSD, with ( = 46) and without ( = 96) comorbid dissociative disorders. Read More

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November 2018
2 Reads

Association between affective disorders presenting before and during pregnancy and pre-term birth, considering socio-demographic factors, obstetric factors, health conditions, and use of medication.

Aten Primaria 2018 Nov 16. Epub 2018 Nov 16.

Unitat de Suport a la Recerca Costa de Ponent, Institut Universitari d'Investigació en Atenció Primària Jordi Gol (IDIAP Jordi Gol), Cornellà de Llobregat, Spain; Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain. Electronic address:

Objective: To study the relationship between maternal affective disorders (AD) before and during pregnancy, and pre-term birth.

Design: Retrospective observational study.

Location: Sexual and reproductive health units at the Institut Català de la Salut (ICS) in Catalonia, Spain. Read More

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November 2018
2 Reads

Ab initio surface hopping excited-state molecular dynamics approach on the basis of spin-orbit coupled states: An application to the A-band photodissociation of CH I.

J Comput Chem 2018 Nov 19. Epub 2018 Nov 19.

Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo, 060-0810, Japan.

Ab initio molecular dynamics approach has been extended to multi-state dynamics on the basis of the spin-orbit coupled electronic states that are obtained through diagonalization of the spin-orbit coupling matrix with the multi-state second-order multireference perturbation theory energies in diagonal elements and the spin-orbit coupling terms at the state-averaged complete active space self-consistent field level in off-diagonal elements. Nonadiabatic transitions over the spin-orbit coupled states were taken into account explicitly by a surface hopping scheme with utilizing the nonadiabatic coupling terms calculated by numerical differentiation of the spin-orbit coupled wavefunctions and analytical nonadiabatic coupling terms. The present method was applied to the A-band photodissociation of methyl iodide, CH I + hv → CH + I ( P )/I* ( P ), for which a pioneering theoretical work was reported by Amatatsu, Yabushita, and Morokuma. Read More

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November 2018
4 Reads

Preliminary Evidence of a Missing Self Bias in Face Perception FOR Individuals with Dissociative Identity Disorder.

J Trauma Dissociation 2018 Nov 16:1-25. Epub 2018 Nov 16.

a Division of Depression and Anxiety Disorders , McLean Hospital , Belmont , MA , USA.

Failing to recognize one's mirror image can signal an abnormality in one's sense of self. In dissociative identity disorder (DID), individuals often report that their mirror image can feel unfamiliar or distorted. They also experience some of their own thoughts, emotions, and bodily sensations as if they are nonautobiographical and sometimes as if instead, they belong to someone else. Read More

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November 2018
10 Reads

Trauma Memory Processing in Posttraumatic Stress Disorder Psychotherapy: A Unifying Framework.

Authors:
Julian D Ford

J Trauma Stress 2018 Nov 16. Epub 2018 Nov 16.

Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA.

Trauma memory processing (TMP) is an empirically supported approach to psychotherapy for posttraumatic stress disorder (PTSD). However, TMP is not a single, uniform intervention but instead a paradigm that can be operationalized through a variety of component procedures that have not been systematically elucidated and formally tested. Based on findings from phenomenological/structural and neuroimaging research, a central feature of PTSD is theorized to be the involuntary immersion in trauma memories with diminished awareness or negative appraisals of self and current context. Read More

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November 2018
8 Reads

Low-dose Ketamine Does Not Improve Migraine in the Emergency Department: A Randomized Placebo-controlled Trial.

West J Emerg Med 2018 Nov 10;19(6):952-960. Epub 2018 Sep 10.

Lewis Gale Medical Center, Department of Emergency Medicine, Salem, Virginia.

Introduction: Patients frequently present to the emergency department (ED) with migraine headaches. Although low-dose ketamine demonstrates analgesic efficacy for acute pain complaints in the ED, headaches have historically been excluded from these trials. This study evaluates the efficacy and safety of low-dose ketamine for treatment of acute migraine in the ED. Read More

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November 2018
7 Reads

State-Dependent Memory: Neurobiological Advances and Prospects for Translation to Dissociative Amnesia.

Front Behav Neurosci 2018 31;12:259. Epub 2018 Oct 31.

Department of Psychology, Northwestern University, Evanston, IL, United States.

In susceptible individuals, overwhelming traumatic stress often results in severe abnormalities of memory processing, manifested either as the uncontrollable emergence of memories (flashbacks) or as an inability to remember events (dissociative amnesia, DA) that are usually, but not necessarily, related to the stressful experience. These memory abnormalities are often the source of debilitating psychopathologies such as anxiety, depression and social dysfunction. The question of why memory for some traumatic experiences is compromised while other comparably traumatic experiences are remembered perfectly well, both within and across individuals, has puzzled clinicians for decades. Read More

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October 2018
7 Reads

Towards a dissociative SPC-like water model II. The impact of Lennard-Jones and Buckingham non-coulombic forces.

Phys Chem Chem Phys 2018 Nov;20(45):28523-28534

Theoretical Chemistry Division, Institute of General, Inorganic and Theoretical Chemistry, Center for Chemistry and Biomedicine, University of Innsbruck, Innrain 80-82, A-6020 Innsbruck, Austria.

The dissociative water model developed by Garofalini and coworkers provides a versatile and effective approach to model proton transfer in a liquid water environment. This work presents the continuation of a previous study aiming at improving the transferability of this model, thereby enabling its application via third party simulation programs. In particular it is probed, whether a re-formulation of the non-coulombic interaction potential in the framework of the more common Lennard-Jones (LJ) and Buckingham formulation is feasible. Read More

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November 2018
4 Reads

The hippocampus is critical for value-based decisions guided by dissociative inference.

Hippocampus 2018 Nov 12. Epub 2018 Nov 12.

Rotman Research Institute at Baycrest Health Sciences, Toronto, Ontario, Canada.

The hippocampus supports flexible decision-making through memory integration: bridging across episodes and inferring associations between stimuli that were never presented together ('associative inference'). A pre-requisite for memory integration is flexible representations of the relationships between stimuli within episodes (AB) but also of the constituent units (A,B). Here we investigated whether the hippocampus is required for parsing experienced episodes into their constituents to infer their re-combined within-episode associations ('dissociative inference'). Read More

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November 2018
4 Reads

Succinic acid enhanced quantitative determination of blood modified nucleosides in the development of diabetic nephropathy based on hydrophilic interaction liquid chromatography mass spectrometry.

J Pharm Biomed Anal 2018 Oct 25;164:309-316. Epub 2018 Oct 25.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China. Electronic address:

The epigenetic modification of DNA or RNA may have relationship with the development of diabetic nephropathy (DN). We designed to develop a liquid chromatography mass spectrometry (LC-MS) coupled with mobile phase additive sensitization method for the analysis of the dissociative epigenetic modified nucleosides in serum of patients from different periods of DN with the health comparison. Serum samples were collected from 43 healthy volunteers and 156 patients, which divided into four groups. Read More

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October 2018
6 Reads

Six-dimensional quantum dynamics for the dissociative chemisorption of HCl on rigid Ag(111) on three potential energy surfaces with different density functionals.

J Chem Phys 2018 Nov;149(17):174702

State Key Laboratory of Molecular Reaction Dynamics and Center for Theoretical and Computational Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, People's Republic of China.

We carried out six-dimensional quantum dynamics calculations for the dissociative chemisorption of HCl on a rigid Ag(111) surface, employing three potential energy surfaces (PESs) which were recently constructed using the neural network approach based on extensive density functional theory calculations with Perdew-Burke-Ernzerhof, Perdew-Wang91, and revised Perdew-Burke-Ernzerhof functionals, respectively. The vibrational excitation of HCl enhances the reactivity substantially, and the dissociation is most favored for HCl molecules colliding with rotation in a plane parallel to the Ag(111) surface (helicopter alignment). The influence of rotational excitation on the dissociation probability is much more complicated, with different trends at high and at low kinetic energies. Read More

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November 2018
5 Reads

[Multiple personalities in a 15-year-old girl].

Ugeskr Laeger 2018 Nov;180(45)

This case report is about a 15-year-old girl, who had multiple personalities. Dissociative identity disorder (DID) is a complex disorder characterised by two or more distinct identities or dissociated personalities. These states or identities alternately control the person's behaviour, accompanied by memory impairment of important information. Read More

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November 2018

A Review of the Neurobiological Basis of Trauma-Related Dissociation and Its Relation to Cannabinoid- and Opioid-Mediated Stress Response: a Transdiagnostic, Translational Approach.

Curr Psychiatry Rep 2018 Nov 7;20(12):118. Epub 2018 Nov 7.

Stanford University School of Medicine, Stanford, CA, USA.

Dissociative experiences have been associated with increased disease severity, chronicity, and, in some cases, reduced treatment response across trauma-related and other psychiatric disorders. A better understanding of the neurobiological mechanisms through which dissociative experiences occur may assist in identifying novel pharmacological and non-pharmacological treatment approaches. Here, we review emerging work on the dissociative subtype of posttraumatic stress disorder (PTSD), and other trauma-related disorders providing evidence for two related overarching neurobiological models of dissociation, the defense cascade model of dissociation and Mobb's threat detection model. Read More

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November 2018
11 Reads

Prevalence of auditory pseudohallucinations in adult survivors of physical and sexual trauma with chronic post-traumatic stress disorder (PTSD).

Behav Res Ther 2018 Dec 30;111:113-118. Epub 2018 Oct 30.

Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, 15 Chaucer Road, Cambridge, CB2 7EF, UK.

Auditory Verbal Hallucinations (AVHs) are commonly associated with psychosis but are also reported in post-traumatic stress disorder (PTSD). Hearing voices after the experience of stress has been conceptualised as a dissociative experience. Brewin and Patel's (2010) seminal study reported that hearing voices is relatively common in PTSD, as hearing voices was associated with PTSD in half and two thirds of military veterans and survivors of civilian trauma, respectively. Read More

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December 2018

Direct observation of atomic step edges on the rutile TiO(110)-(1 × 1) surface using atomic force microscopy.

Phys Chem Chem Phys 2018 Nov;20(44):28331-28337

Department of Applied Physics, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

Clarifying the atomic configuration of step edges on a rutile TiO2 surface is crucial for understanding its fundamental reactivity, and the direct observation of atomic step edges is still a challenge. AFM is a powerful tool for investigating surface structures with true atomic resolution, and it provides the opportunity to resolve the real structure of step edges with improved techniques. In this work, we successfully imaged the atomic configuration of 001 and 1-11 step edges on the surface of rutile TiO2(110)-(1 × 1), and we present the direct observation of oxygen vacancies along the 1-11 step edges, indicating that one 1-11 step edge site corresponds to one oxygen vacancy using AFM. Read More

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November 2018
4 Reads
4.490 Impact Factor

Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy.

EBioMedicine 2018 Nov 2. Epub 2018 Nov 2.

Department of Physiology & Medical Physics, RCSI, Dublin, Ireland; FutureNeuro Research Centre, RCSI, Dublin, Ireland. Electronic address:

Background: There are no blood-based molecular biomarkers of temporal lobe epilepsy (TLE) to support clinical diagnosis. MicroRNAs are short noncoding RNAs with strong biomarker potential due to their cell-specific expression, mechanistic links to brain excitability, and stable detection in biofluids. Altered levels of circulating microRNAs have been reported in human epilepsy, but most studies collected samples from one clinical site, used a single profiling platform or conducted minimal validation. Read More

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November 2018
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Do I focus on the process of cycling or try to put my mind elsewhere? A comparison of concentration strategies for use in pacing by novice riders.

Prog Brain Res 2018 13;240:127-140. Epub 2018 Oct 13.

University of Wolverhampton, Wolverhampton, United Kingdom. Electronic address:

The ability to hold a pace is a key skill for endurance athletes. The present study compared the influence of different strategies on how athletes learn to pace at 80% of their maximum performance for a 3-min cycle time trial. Participants first completed three maximal 3-min tests to establish maximal performance. Read More

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October 2018
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The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations.

Immunity 2018 Nov 30;49(5):829-841.e6. Epub 2018 Oct 30.

Laboratory of Immunobiology and Department of Medical Oncology, Dana-Farber Cancer Institute, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Initial molecular details of cellular activation following αβT cell antigen receptor (TCR) ligation by peptide-major histocompatibility complexes (pMHC) remain unexplored. We determined the nuclear magnetic resonance (NMR) structure of the TCRα subunit transmembrane (TM) domain revealing a bipartite helix whose segmentation fosters dynamic movement. Positively charged TM residues Arg251 and Lys256 project from opposite faces of the helix, with Lys256 controlling immersion depth. Read More

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November 2018
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