15,394 results match your criteria Disseminated Intravascular Coagulation


Successful Management of Severe Exertional Heat Stroke with Endovascular Cooling After Failure of Standard Cooling Measures.

J Emerg Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Emergency Medicine, Martin Army Community Hospital, Fort Benning, Georgia.

Background: Exertional heat stroke (EHS) is a potentially life-threatening emergency requiring rapid reduction in core body temperature. Methods of cooling include cold water immersion, ice packs, cold water lavage, and chilled saline, among others. We report a case of EHS successfully cooled using an endovascular cooling device after traditional cooling methods failed to reduce core body temperature. Read More

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http://dx.doi.org/10.1016/j.jemermed.2019.03.025DOI Listing

Markers of Inflammation and Infection in Sepsis and Disseminated Intravascular Coagulation.

Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029619843338

1 Department of Pathology, Loyola University Medical Center, Maywood, IL, USA.

Sepsis is a severe systemic inflammatory response to infection that manifests with widespread inflammation as well as endothelial and coagulation dysfunction that may lead to hypotension, organ failure, shock, and death. Disseminated intravascular coagulation (DIC) is a complication of sepsis involving systemic activation of the fibrinolytic and coagulation pathways that can lead to multi-organ dysfunction, thrombosis, and bleeding, with a 2-fold increase in mortality. This study demonstrates the diagnostic and prognostic value of profiling various biomarkers of inflammation and infection in patients with sepsis-associated DIC to assess the severity of illness. Read More

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http://journals.sagepub.com/doi/10.1177/1076029619843338
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http://dx.doi.org/10.1177/1076029619843338DOI Listing
April 2019
2 Reads

Disseminated intravascular coagulation during liver transplantation unleashed by protamine.

J Clin Anesth 2019 Apr 13;57:117-118. Epub 2019 Apr 13.

Department of Anesthesia, University of Miami/Jackson Memorial Hospital, Miami, FL, United States of America; Miami Transplant Institute, University of Miami/Jackson Memorial Hospital, Miami, FL, United States of America.

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http://dx.doi.org/10.1016/j.jclinane.2019.04.017DOI Listing
April 2019
1 Read

Pancytopenia as a Consequence of Sepsis and Intravenous Antibiotic Drug Toxicity.

Cureus 2019 Feb 1;11(2):e3994. Epub 2019 Feb 1.

Internal Medicine, Ocala Regional Medical Center/ University of Central Florida College of Medicine, Ocala, USA.

This case involves a 62-year-old male with a prior history of epidural abscess and L1-L2 osteodiscitis who was admitted because of low back pain. The patient was previously treated for methicillin-susceptible Staphylococcus aureus (MSSA) discitis in the L1/L2 vertebral region with intravenous (IV) nafcillin through a peripherally inserted central catheter (PICC). However, he returned after four months with recurrent low back pain along with chills and fever. Read More

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https://www.cureus.com/articles/17399-pancytopenia-as-a-cons
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http://dx.doi.org/10.7759/cureus.3994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443538PMC
February 2019
2 Reads

TEG in the monitoring of coagulation changes in patients with sepsis and the clinical significance.

Exp Ther Med 2019 May 5;17(5):3373-3382. Epub 2019 Mar 5.

Department of Intensive Care Unit, General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China.

Application values of thromboelastography (TEG) in dynamic monitoring of coagulation parameters of sepsis patients were investigated. Eighty-one patients with sepsis who were admitted to the ICU department of the General Hospital of Ningxia Medical University from April 1, 2015 to December 31, 2015 were collected. Clinical data of the patients were collected. Read More

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http://dx.doi.org/10.3892/etm.2019.7342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447775PMC
May 2019
1 Read

Reduced Mannose-Binding Lectin-Associated Serine Protease (MASP)-1 is Associated with Disturbed Coagulation in Septic Shock.

Thromb Haemost 2019 Apr 15. Epub 2019 Apr 15.

Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.

Background:  Activation of the complement system is part of the dysregulated immune response in sepsis. The mannose-binding lectin-associated serine proteases (MASP)-1 and -2 activate the lectin pathway of the complement system. Besides, these proteins can activate coagulation in vitro. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685140
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http://dx.doi.org/10.1055/s-0039-1685140DOI Listing
April 2019
3 Reads

A probable case of catastrophic antiphospholipid syndrome: Should high-dose steroids be given in the setting of polymicrobial sepsis?

SAGE Open Med Case Rep 2019 1;7:2050313X19839531. Epub 2019 Apr 1.

Department of Medicine, Weill Cornell Medicine/New York-Presbyterian Hospital, New York, NY, USA.

In this clinical vignette, we present a case of a 59-year-old woman with catastrophic antiphospholipid syndrome likely triggered by polymicrobial sepsis. The diagnostic criteria and clinical manifestations of catastrophic antiphospholipid syndrome are reviewed. We also compare diagnostic criteria and clinical manifestations with other clinical entities in the differential diagnosis, including thrombotic thrombocytopenic purpura-hemolytic-uremic syndrome, disseminated intravascular coagulation, sepsis, and inflammatory bowel disease. Read More

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http://dx.doi.org/10.1177/2050313X19839531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444769PMC
April 2019
1 Read

The effectiveness of prophylactic internal iliac artery balloon occlusion in the treatment of patients with pernicious placenta previa coexisting with placenta accreta.

J Matern Fetal Neonatal Med 2019 Apr 9:1-6. Epub 2019 Apr 9.

a Department of Obstetrics , Chengdu Women's and Children's Central Hospital , Chengdu , China.

Aim: This study aimed to explore the therapeutic effectiveness of prophylactic internal iliac artery balloon occlusion (IIABO) during cesarean delivery in the management of patients with pernicious placenta previa (PPP) coexisting with placenta accreta (PA).

Methods: This retrospectively study enrolled 83 patients diagnosed with PPP coexisting with PA in our hospital between January 2014 and December 2017. The patients were divided into the study group (n = 58, receiving routine cesarean section followed prophylactic IIABO) and control group (n = 25, receiving routine cesarean section alone). Read More

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http://dx.doi.org/10.1080/14767058.2019.1599350DOI Listing
April 2019
1 Read

Bacteria-released outer membrane vesicles promote disseminated intravascular coagulation.

Thromb Res 2019 Mar 28;178:26-33. Epub 2019 Mar 28.

Department of Hematology, The 3rd Xiangya Hospital, Central South University, Changsha, PR China; State Key Laboratory of Medical Genetics, School of Biological Science and Technology, Central South University, Changsha, Hunan Province, PR China; Department of Pathophysiology, School of Basic Medical Science, Jinan University, Guangzhou, Guangdong Province, PR China; Key Laboratory of Non-resolving Inflammation and Cancer of Hunan Province, The 3rd Xiangya Hospital, Central South University, Changsha, PR China. Electronic address:

Introduction: Sepsis is frequently complicated by disseminated intravascular coagulation (DIC), which promotes multiple organ dysfunctions and significantly increase the mortality of patients with sepsis. How bacteria cause DIC is not fully understood. Outer membrane vesicles (OMVs) are membrane-enclosed microvesicles released by variety of bacteria. Read More

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http://dx.doi.org/10.1016/j.thromres.2019.03.019DOI Listing
March 2019
4 Reads

Unconscious Woman in Shock and Covered with Ants Pulled from an Abandoned Automobile.

Am J Med 2019 Apr 3. Epub 2019 Apr 3.

Department of Medicine, College of Medicine, Washington, DC. Electronic address:

A middle-aged female was taken from an abandoned automobile unconscious and covered with ants in Tucson, AZ. When hospitalized in July 2018 she had an extensive papular-pustular skin eruption on her abdomen and thigh and disseminated intravascular coagulation (DIC). She had been stung innumerable times by native golden fire ants (Solenopsis aurea) while sleeping in the vehicle. Read More

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http://dx.doi.org/10.1016/j.amjmed.2019.02.053DOI Listing
April 2019
1 Read

Varicella gangrenosum in adult: a fatal chickenpox complication.

BMJ Case Rep 2019 Apr 4;12(4). Epub 2019 Apr 4.

Urology, King George's Medical University, Lucknow, Uttar-Pradesh, India.

Varicella gangrenosum is a gangrenous ulceration of varicella lesions involving the skin and soft tissues of the body. The term was coined more than 100 years ago. This occurs due to superimposed bacterial infection. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22636
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http://dx.doi.org/10.1136/bcr-2018-226363DOI Listing
April 2019
6 Reads

The D-dimer assay.

Am J Hematol 2019 Apr 4. Epub 2019 Apr 4.

Division of Hematology and Hematologic Malignancies, University of Utah Health Sciences Center, Salt Lake City, Utah.

D-dimer is an indirect marker of fibrinolysis and fibrin turnover; this molecule exhibits unique properties as a biological marker of hemostatic abnormalities as well as an indicator of intravascular thrombosis. D-dimer is a soluble fibrin degradation product that results from the systematic degradation of vascular thrombi through the fibrinolytic mechanism. Because of this, the D-dimer serves as a valuable marker of activation of coagulation and fibrinolysis in a number of clinical scenarios. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ajh.25482
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http://dx.doi.org/10.1002/ajh.25482DOI Listing
April 2019
1 Read

[Risk factors of surgical treatment of acute aortic dissection type A (in Russian only)].

Khirurgiia (Mosk) 2019 (3):15-20

Pirogov Russian National Research Medical University, Moscow, Russia.

Aim: To evaluate risk factors of surgical treatment of acute aortic dissection type A.

Material And Methods: Retrospective analysis included 100 patients with acute aortic dissection type A who underwent surgery in 2007-2017. Patients were divided into 2 groups: group I (survivors, n=79) and group II (unfavorable outcomes, n=21). Read More

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http://dx.doi.org/10.17116/hirurgia201903115DOI Listing
January 2019

Markers of Fibrinolysis in Indian Patients with Isolated Head Trauma.

Asian J Neurosurg 2019 Jan-Mar;14(1):118-121

Department of Neurosurgery, University College of Medical Sciences and Guru Teg Bahadur Hospital Hospital, New Delhi, India.

Context: Head injury causes disseminated intravascular coagulation as the most severe complication which is associated with high mortality. Elevated levels of markers of fibrinolysis such as D-dimer and fibrinopeptide A (FPA) have been correlated with poor outcome in these patients.

Aim: The study aimed to correlate the levels of plasma fibrinogen, D-dimer, and FPA with outcome in patients with isolated head trauma. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_278_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417324PMC
April 2019
2 Reads

Ocular infiltration as initial presentation of acute monocytic leukaemia transformed from chronic myelomonocytic leukaemia associated with V600E mutation.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Department of Clinical Haematology, Monash Health, Clayton, Victoria, Australia.

Acute monocytic leukaemia (French-British-American classification: AML-M5b) is characterised by a predominance of cells of the monocytic lineage on bone marrow examination. Furthermore, a discerning feature is its tendency for tissue infiltration. While gum hypertrophy and hepatosplenomegaly are common, ocular involvement is rare. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22851
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http://dx.doi.org/10.1136/bcr-2018-228519DOI Listing
March 2019
5 Reads

Surgery-first treatment improves clinical results in infective endocarditis complicated with disseminated intravascular coagulation†.

Eur J Cardiothorac Surg 2019 Apr 1. Epub 2019 Apr 1.

Department of Cardiovascular Surgery, Osaka University Hospital, Osaka, Japan.

Objectives: Infective endocarditis (IE) is a critical infection with a high mortality rate, and it usually causes sepsis. Though disseminated intravascular coagulation (DIC) sometimes occurs in IE patients, no definitive treatment strategy for IE patients with DIC as a complication exists. Therefore, we evaluated the prevalence, surgical results and treatment strategy for IE complicated with DIC. Read More

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http://dx.doi.org/10.1093/ejcts/ezz068DOI Listing
April 2019
3 Reads

CT-Proven Ischaemic Stroke as the First Manifestation of Occult Lung Cancer.

Eur J Case Rep Intern Med 2019 18;6(1):001007. Epub 2019 Jan 18.

Internal Medicine Service 1.2, Hospital de São José, Centro Hospitalar Universitário Lisboa Central, E.P.E., Lisbon, Portugal.

Cancer is associated with a higher risk of stroke, and in rare cases stroke can be the first manifestation of occult neoplasia. We present the case of a 74-year-old woman hospitalized for ischaemic stroke with multiple cerebral infarctions in several vascular territories. The exclusion of other aetiologies and the simultaneous presence of thromboembolic events in other organs raised the suspicion of a hypercoagulable state, which upon investigation revealed occult neoplasia of the lung. Read More

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http://dx.doi.org/10.12890/2019_001007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432875PMC
January 2019
2 Reads

Postpartum hemorrhage and risk for postpartum readmission.

J Matern Fetal Neonatal Med 2019 Apr 9:1-8. Epub 2019 Apr 9.

b Department of Obstetrics and Gynecology , Columbia University Irving Medical Center , New York , NY , USA.

Objective: This study had two objectives: (i) to evaluate risk factors for postpartum readmission for a primary diagnosis of postpartum hemorrhage (PPH) among all women, and (ii) to determine risk for postpartum readmission specifically among women with PPH during their delivery hospitalization.

Methods: The Healthcare Cost and Utilization Project's Nationwide Readmissions Database for 2010 to 2014 was used to evaluate risk for postpartum readmission for PPH within 60 days of discharge from a delivery hospitalization. Obstetric, medical, demographic, and hospital factors including PPH during the index delivery were analyzed. Read More

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http://dx.doi.org/10.1080/14767058.2019.1601697DOI Listing
April 2019
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The Treatment Intensity of Anticoagulant Therapy for Patients With Sepsis-Induced Disseminated Intravascular Coagulation and Outcomes: A Multicenter Cohort Study.

Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029619839154

9 Department of Emergency Medicine, University of Occupational and Environmental Health, Kitakyusyu, Japan.

We examined the institutional variations in anticoagulation therapy for sepsis-induced disseminated intravascular coagulation (DIC) and their effects on patient outcomes. This post hoc analysis of a cohort study included 3195 patients with severe sepsis across 42 intensive care units. To evaluate differences in the intensity of anticoagulation therapy, the proportion of patients receiving anticoagulation therapy and the total number of patients with sepsis-induced DIC were compared. Read More

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http://dx.doi.org/10.1177/1076029619839154DOI Listing
March 2019
1 Read

Disseminated Intravascular Coagulation-like Reaction after Rituximab Infusion in a Patient with Nephrotic Syndrome: A Case Report.

Intern Med 2019 Mar 28. Epub 2019 Mar 28.

Division of Nephrology, Department of Medicine, Showa University Fujigaoka Hospital, Japan.

Several case series have suggested that rituximab is efficacious in adult patients with minimal change disease. We herein report a case of disseminated intravascular coagulation-like reaction after rituximab infusion in a patient with nephrotic syndrome. A 58-year-old Japanese man with minimal change disease diagnosed 15 years earlier was started on rituximab to prevent relapse of nephrotic syndrome when he presented to our clinic with low albuminemia, massive proteinuria, and leg edema. Read More

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http://dx.doi.org/10.2169/internalmedicine.2236-18DOI Listing
March 2019
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Disseminated carcinomatosis of the bone marrow from gastric cancer during pregnancy.

Clin J Gastroenterol 2019 Mar 26. Epub 2019 Mar 26.

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Gastric cancer during pregnancy is extremely rare and difficult to diagnose at early stages because of its nature. Furthermore, it is often difficult to determine the appropriate treatment strategy considering both the patient's condition and the effect of the treatment on the fetus. We present a case of a 34-year-old woman with gastric cancer who was 22 weeks pregnant and had multiple liver and bone metastases at the time of diagnosis. Read More

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http://dx.doi.org/10.1007/s12328-019-00963-1DOI Listing
March 2019
1 Read

[Carcinoma of the Ascending Colon Showing Rapid Progression of Disseminated Carcinomatosis of the Bone Marrow-Report of a Case].

Gan To Kagaku Ryoho 2019 Feb;46(2):285-287

Dept. of Surgery, Rinku General Medical Center.

A 72-year-old man with ascending colon cancer was admitted to our hospital. Right hemicolectomy and lymph node dissection(D3)were performed. The pathological diagnosis was signet-ring cell carcinoma, T4a(SE), N2b, M1a(LYM), Stage Ⅳ, R0, Cur B. Read More

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February 2019
1 Read

Coagulotoxic effects by brown snake (Pseudonaja) and taipan (Oxyuranus) venoms, and the efficacy of a new antivenom.

Toxicol In Vitro 2019 Mar 22;58:97-109. Epub 2019 Mar 22.

Venom Evolution Lab, School of Biological Sciences, The University of Queensland, St. Lucia, QLD 4072, Australia. Electronic address:

Snakebite is a neglected tropical disease that disproportionately affects the poor. Antivenom is the only specific and effective treatment for snakebite, but its distribution is severely limited by several factors, including the prohibitive cost of some products. Papua New Guinea (PNG) is a snakebite hotspot but the high costs of Australian antivenoms (thousands of dollars per treatment) makes it unaffordable in PNG. Read More

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http://dx.doi.org/10.1016/j.tiv.2019.03.031DOI Listing
March 2019
1 Read

[Intravascular lymphoma simulating relapse of breast cancer: An original clinical case].

Ann Dermatol Venereol 2019 Mar 20. Epub 2019 Mar 20.

Service de dermatologie et vénérologie, hôpitaux civils de Colmar, 39, avenue de la Liberté, 68000 Colmar, France.

Background: Intravascular lymphoma is a rare form of non-Hodgkin's lymphoma with varied but highly evocative clinical presentations, particularly in terms of dermatology. Histological examination of the skin may be sufficient to allow diagnosis.

Patients And Methods: Herein, we report the case of a 75-year-old woman with a history of infiltrative ductal carcinoma of the left breast who was hospitalised for neurological evaluation following repeated falls. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01519638193004
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http://dx.doi.org/10.1016/j.annder.2019.01.012DOI Listing
March 2019
4 Reads

Autoimmune heparin-induced thrombocytopenia and venous limb gangrene after aortic dissection repair: in vitro and in vivo effects of intravenous immunoglobulin.

Transfusion 2019 Mar 23. Epub 2019 Mar 23.

Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

Background: Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder characterized by heparin-dependent antibodies that activate platelets (PLTs) via PLT FcγIIa receptors. "Autoimmune" HIT (aHIT) indicates a HIT subset where thrombocytopenia progresses or persists despite stopping heparin; aHIT sera activate PLTs strongly even in the absence of heparin (heparin-independent PLT-activating properties). Affected patients are at risk of severe complications, including dual macro- and microvascular thrombosis leading to venous limb gangrene. Read More

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http://dx.doi.org/10.1111/trf.15263DOI Listing
March 2019
2 Reads

Japanese Clinical Practice Guidelines for Sacrococcygeal Teratoma, 2017.

Pediatr Int 2019 Mar 22. Epub 2019 Mar 22.

Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Sacrococcygeal teratoma (SCT) is the most common extragonadal germ cell tumor in neonates and infants. Although most cases of infantile SCT are benign tumors by nature, some develop into extremely large lesions, leading to massive bleeding, high-output heart failure, disseminated intravascular coagulation, and even fatal outcomes during the neonatal period. In addition, some cases may present with tumor recurrence, malignant transformation, long-term sequelae (including bladder and bowel dysfunction) and lower leg palsy during the long-term follow-up. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ped.13844
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http://dx.doi.org/10.1111/ped.13844DOI Listing
March 2019
4 Reads

A confirmed bite by a Beautiful Pit Viper (Trimeresurus venustus) resulting in local symptoms.

Toxicon 2019 Mar 20;163:44-47. Epub 2019 Mar 20.

National Poisons Information Centre, Tox Info Suisse, Associated Institute of the University of Zurich, Zurich, Switzerland.

This case report describes the effect of an envenomation by the Beautiful Pit Viper Trimeresurus venustus (or Cryptelytrops venustus), which is a green pit viper native to Thailand and Malaysia. A previously healthy 60-year-old snake breeder with no relevant medical history was bitten by his adult T. venustus in the third finger of his right hand while taking it out of the feeding box. Read More

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http://dx.doi.org/10.1016/j.toxicon.2019.03.019DOI Listing
March 2019
2 Reads
2.492 Impact Factor

Four-extremity amputation following disseminated intravascular coagulation and purpura fulminans.

BMJ Case Rep 2019 Mar 20;12(3). Epub 2019 Mar 20.

Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.

Purpura fulminans (PF) is a rare but serious complication of septic shock in adults. The complex disease course makes it challenging to manage the condition. Here, we present the case of a healthy young woman who presented with sepsis and new-onset erythematous lesions 4 days after the vaginal delivery of a healthy baby. Read More

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http://dx.doi.org/10.1136/bcr-2018-228028DOI Listing
March 2019
1 Read

Next Generation Medical Management of Postpartum Hemorrhage.

Curr Pharm Des 2019 Mar 20. Epub 2019 Mar 20.

The George Washington University, School of Medicine and Health Sciences, Washington, DC. United States.

Background: Postpartum hemorrhage remains a significant contributor to morbidity and mortality of women of childbearing age worldwide. Trends in both incidence and severity of postpartum hemorrhage are increasing which has resulted in an imperative to identify drugs that could target prevention and/or treatment of these postpartum hemorrhages in women living in high, middle and low-income countries.

Method: We have reviewed current advances in the medical management of postpartum hemorrhage focusing on non-uterotonic therapy. Read More

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http://dx.doi.org/10.2174/1381612825666190320155337DOI Listing
March 2019
2 Reads

Complement in Thrombotic Microangiopathies: Unraveling Ariadne's Thread Into the Labyrinth of Complement Therapeutics.

Front Immunol 2019 27;10:337. Epub 2019 Feb 27.

Division of Biodiagnostic Sciences and Technologies, INRASTES, National Center for Scientific Research Demokritos, Athens, Greece.

Thrombotic microangiopathies (TMAs) are a heterogeneous group of syndromes presenting with a distinct clinical triad: microangiopathic hemolytic anemia, thrombocytopenia, and organ damage. We currently recognize two major entities with distinct pathophysiology: thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). Beyond them, differential diagnosis also includes TMAs associated with underlying conditions, such as drugs, malignancy, infections, scleroderma-associated renal crisis, systemic lupus erythematosus (SLE), malignant hypertension, transplantation, HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets), and disseminated intravascular coagulation (DIC). Read More

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http://dx.doi.org/10.3389/fimmu.2019.00337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413705PMC
February 2019
2 Reads

A case of recurrent angiosarcoma with isolated bone marrow metastasis presented as acute disseminated intravascular coagulation.

Kaohsiung J Med Sci 2019 Apr 19;35(4):244-245. Epub 2019 Mar 19.

Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1002/kjm2.12039DOI Listing
April 2019
1 Read

Addressing the room for improvement in management of acute promyelocytic leukemia.

Eur J Haematol 2019 Mar 19. Epub 2019 Mar 19.

Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.

Acute promyelocytic leukemia (APL) is highly curable. To achieve high cure rates, targeted therapy with retinoic acid (ATRA) must be started promptly at time of suspected diagnosis. Early death rates (EDRs, ≤30 days from diagnosis) differ markedly in patients treated on clinical trials compared to the general population. Read More

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http://dx.doi.org/10.1111/ejh.13229DOI Listing
March 2019
2 Reads

Internal Iliac Artery Balloon Tamponade in Placenta Accreta: Outcomes From the Largest Tertiary Accreta Referral Centre in British Columbia.

J Obstet Gynaecol Can 2019 Apr 27;41(4):466-472. Epub 2018 Oct 27.

Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC.

Objective: Placenta accreta syndromes are well-recognized risk factors for severe postpartum hemorrhage and are associated with significant maternal morbidity. Internal iliac artery balloon tamponade is an adjunctive procedure used to reduce blood loss at the time of Caesarean hysterectomy with variable results in the reported literature. This study investigated the outcomes of preoperative balloon tamponade at the largest tertiary referral centre for placenta accreta in British Columbia. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.06.020DOI Listing
April 2019
1 Read

[Value of APACHE.II score and DIC score in predicting the death of patients with heat stroke].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2019 Jan;37(1):43-45

Department of Emergency Medicine, Harrison International Peace Hospital Affiliated to Hebei Medical University, Hengshui 053000, China.

To investigate the predictive values of the acute physiology and chronic health evaluation II (APACHE.II) score and disseminated intravascular coagulation (DIC) score on death in patients with heat stroke. A total of 76 patients with heat stroke who were treated in Emergency Department of Harrison International Peace Hospital from June 2013 to September 2017 were studied. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2019.01.009DOI Listing
January 2019
1 Read

A case of cerebral infarction in a patient with TAFRO syndrome.

J Neurol Sci 2019 May 12;400:21-22. Epub 2019 Mar 12.

Department of Stroke Medicine, Kawasaki Medical School, Okayama, Japan.

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http://dx.doi.org/10.1016/j.jns.2019.03.006DOI Listing
May 2019
1 Read

Meningococcal purpura fulminans and severe myocarditis with clinical meningitis but no meningeal inflammation: a case report.

BMC Infect Dis 2019 Mar 12;19(1):252. Epub 2019 Mar 12.

Assistance Publique-Hôpitaux de Paris (APHP), Tenon University Hospital, Medico-Surgical Intensive Care Unit, 4 Rue de la Chine, Paris, 75020, France.

Background: During fulminant meningococcal septicaemia, meningococci are often observed in the cerebrospinal fluid (CSF) although the patients have frequently no meningeal symptoms. Meningococcal meningitis, by contrast, usually features clinical meningeal signs and biochemical markers of inflammation with elevated white blood cell count (pleiocytosis) in the CSF. Cases of typical symptomatic meningitis without these biochemical features are uncommon in adults. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3866-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419487PMC
March 2019
7 Reads

Characteristics and relative numbers of lethal snake bite cases in medicolegal practice in central Myanmar - A five year study.

J Forensic Leg Med 2019 Apr 5;63:52-55. Epub 2019 Mar 5.

The University of Adelaide Medical School, Frome Road, Adelaide, SA, 5005, Australia; Forensic Science SA, 21 Divett Place, Adelaide, SA, 5000, Australia. Electronic address:

Clinical and pathological case files of lethal snakebites were reviewed from the XXXX, Magway, Myanmar, over a five-year period (January 2013 December 2017). A total of 2069 postmortem examinations were performed which included 84 cases of lethal snake bite (4.1%). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1752928X183050
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http://dx.doi.org/10.1016/j.jflm.2019.03.005DOI Listing
April 2019
4 Reads

The impact of the abruption severity and the onset-to-delivery time on the maternal and neonatal outcomes of placental abruption.

J Matern Fetal Neonatal Med 2019 Mar 8:1-9. Epub 2019 Mar 8.

a Department of Obstetrics and Gynecology , Japanese Red Cross Nagoya Daiichi Hospital , Nagoya , Japan.

Objective: We examined the impact of the abruption severity and the onset-to-delivery time on the maternal and neonatal outcomes of cases of clinically diagnosed placental abruption (PA).

Material And Methods: We investigated 84 patients who were diagnosed with PA at our hospital from January 2009 to September 2017. We classified the patients with PA into three groups based on the extent of the abruption: (1) mild abruption, <20%; (2) moderate abruption, 20-49%; (3) severe abruption, ≥50%, which was defined by the attending obstetricians at the time of delivery. Read More

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http://dx.doi.org/10.1080/14767058.2019.1585424DOI Listing
March 2019
1 Read

Elevated plasma levels of hepatocyte growth factor in rats experimentally envenomated with Bothrops jararaca venom: Role of snake venom metalloproteases.

Toxicon 2019 Apr 6;162:9-14. Epub 2019 Mar 6.

Laboratory of Pathophysiology, The Butantan Institute, Av. Dr. Vital Brazil 1500, CEP 05503-900, São Paulo, Brazil.

The hepatocyte growth factor (HGF)/c-met pathway, which mainly consists of HGF activator (HGFA) and its substrate HGF, protects various types of cells via anti-apoptotic and anti-inflammatory signals. Thrombin is the main physiological activator of such plasmatic pathway, and increased plasma concentrations of HGF have been considered as a molecular marker for some pathological conditions, such as disseminated intravascular coagulation. Since thrombin generation is often linked to tissue injury, and these events are common during snake venom-induced consumption coagulopathies (VICC), our goals were to examine whether Bothrops jararaca venom (Bjv), which induces VICC in vivo: (i) activates the HGF/c-met pathway in vivo and (ii) cleaves zymogen forms of HGFA and HGF (proHGFA and proHGF, respectively) in vitro. Read More

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http://dx.doi.org/10.1016/j.toxicon.2019.03.003DOI Listing
April 2019
4 Reads

Predictors of early hemorrhage in acute promyelocytic leukemia.

Leuk Lymphoma 2019 Mar 8:1-10. Epub 2019 Mar 8.

a Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai Tisch Cancer Institute , New York , NY , USA.

Fatal hemorrhage is the most common cause of induction failure and death among patients with acute promyelocytic leukemia (APL). However, there remains no established means of hemorrhagic risk stratification in APL. In this single center retrospective study of 43 patients treated for APL group-based trajectory modeling was used to identify laboratory trends associated with major bleeding. Read More

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https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1
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http://dx.doi.org/10.1080/10428194.2019.1581187DOI Listing
March 2019
8 Reads

Sudden death due to pulmonary embolism after minor ankle surgery.

BMJ Case Rep 2019 Mar 6;12(3). Epub 2019 Mar 6.

Internal Medicine, Abington Jefferson Health, Abington, Pennsylvania, USA.

Venous thromboembolism prophylaxis guidelines are clear for major orthopaedic surgeries, but data regarding ankle surgery are insufficient. Death from pulmonary embolism (PE) after ankle surgery is rare with the frequency of less than 0.037%. Read More

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http://dx.doi.org/10.1136/bcr-2018-227649DOI Listing
March 2019
2 Reads

Optimal Timing and Early Intervention With Anticoagulant Therapy for Sepsis-Induced Disseminated Intravascular Coagulation.

Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029619835055

1 Division of Trauma and Surgical Critical Care, Osaka General Medical Center, Sumiyoshi, Osaka, Japan.

Optimizing diagnostic criteria to detect specific patients likely to benefit from anticoagulants is warranted. A cutoff of 5 points for the International Society on Thrombosis and Haemostasis overt disseminated intravascular coagulation (DIC) scoring system was determined in the original article, but its validity was not evaluated. This study aimed to explore the optimal cutoff points of DIC scoring systems and evaluate the effectiveness of early intervention with anticoagulants. Read More

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http://dx.doi.org/10.1177/1076029619835055DOI Listing
March 2019
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Impact of Antithrombin Supplementation and Concomitant Anticoagulation Therapy in Pediatric Patients With Disseminated Intravascular Coagulation.

Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029619834350

3 Division of Critical Care Medicine, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan.

We aimed to evaluate the efficacy and safety of antithrombin (AT) supplementation and concomitant anticoagulation therapy in 65 children who met the Japanese Ministry of Health and Welfare (JMHW) disseminated intravascular coagulation (DIC) criteria and had received AT concentrate and/or other concomitant anticoagulants. The primary efficacy end point was to determine standardized mortality ratio (SMR). The secondary efficacy end points were DIC resolution rate and pediatric sequential organ failure assessment (pSOFA) score on day 3. Read More

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http://dx.doi.org/10.1177/1076029619834350DOI Listing
March 2019
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How we manage haemostasis during sepsis.

Br J Haematol 2019 Apr 3;185(2):209-218. Epub 2019 Mar 3.

Cardiometabolic Programme-NIHR UCLH/UCL BRC, London, UK.

Sepsis may be associated with activation of the coagulation system and, in its most severe form, may result in disseminated intravascular coagulation (DIC). Initially, there is thrombosis primarily affecting small and medium sized vessels and contributing to organ dysfunction, but continued activation results in consumption of coagulation factors. This results in prolongation of global coagulation parameters. Read More

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http://dx.doi.org/10.1111/bjh.15821DOI Listing
April 2019
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Senescence-accelerated mice (SAMP1/TA-1) treated repeatedly with lipopolysaccharide develop a condition that resembles hemophagocytic lymphohistiocytosis.

Haematologica 2019 Feb 28. Epub 2019 Feb 28.

Nihon University School of Medicine.

Hemophagocytic lymphohistiocytosis is a life-threatening systemic hyperinflammatory disorder with primary and secondary forms. Primary hemophagocytic lymphohistiocytosis is associated with inherited defects in various genes that affect the immunological cytolytic pathway. Secondary hemophagocytic lymphohistiocytosis is not inherited, but complicates various medical conditions including infection, autoinflammatory/autoimmune disease, and malignant disease. Read More

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http://dx.doi.org/10.3324/haematol.2018.209551DOI Listing
February 2019
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An Interpretable ICU Mortality Prediction Model Based on Logistic Regression and Recurrent Neural Networks with LSTM units.

AMIA Annu Symp Proc 2018 5;2018:460-469. Epub 2018 Dec 5.

Brigham and Women's Hospital.

Most existing studies used logistic regression to establish scoring systems to predict intensive care unit (ICU) mortality. Machine learning-based approaches can achieve higher prediction accuracy but, unlike the scoring systems, frequently cannot provide explicit interpretability. We evaluated an interpretable ICU mortality prediction model based on Recurrent Neural Networks (RNN) with long short-term memory(LSTM)units. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371274PMC
December 2018
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Inhibition of contact-mediated activation of factor XI protects baboons against -induced organ damage and death.

Blood Adv 2019 Feb;3(4):658-669

Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK.

infections can produce systemic bacteremia and inflammation in humans, which may progress to severe sepsis or septic shock, even with appropriate antibiotic treatment. Sepsis may be associated with disseminated intravascular coagulation and consumptive coagulopathy. In some types of mouse infection models, the plasma coagulation protein factor XI (FXI) contributes to the pathogenesis of sepsis. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018029983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391670PMC
February 2019
12 Reads

Usefulness of Measuring Changes in SOFA Score for the Prediction of 28-Day Mortality in Patients With Sepsis-Associated Disseminated Intravascular Coagulation.

Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029618824044

5 Department of Anesthesiology and Critical Care, Duke University School of Medicine, Durham, NC, USA.

The primary end point for sepsis trial is 28-day mortality. However, additional methods for determining the efficacy may have benefits. The purpose of this study was to search a useful indicator of anticoagulant therapy in patients with sepsis with disseminated intravascular coagulation (DIC). Read More

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http://dx.doi.org/10.1177/1076029618824044DOI Listing
February 2019
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Changes in Mannose-Binding Lectin and Collectin Kidney 1 Levels in Sepsis Patients With and Without Disseminated Intravascular Coagulation.

Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029618821189

2 Department of Microbiology and Immunochemistry, Asahikawa Medical University, Asahikawa, Japan.

In sepsis, systemic coagulation activation frequently causes disseminated intravascular coagulation (DIC), and the uncontrolled activation of the complement system can induce multiple organ dysfunction and poor prognosis. This study aimed to examine the association of DIC with levels of collectin kidney 1 (CL-K1), a novel collectin of the complement system, and mannose-binding lectin (MBL), a classical-type collectin in patients with sepsis. We collected blood samples prospectively from adult patients with sepsis admitted to the intensive care unit (ICU) from day 1 (admission) to day 5. Read More

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http://dx.doi.org/10.1177/1076029618821189DOI Listing
February 2019
3 Reads