15,332 results match your criteria Disseminated Intravascular Coagulation


Multicenter clinical experience with recombinant soluble thrombomodulin for disseminated intravascular coagulation associated with severe acute cholecystitis.

Thromb Res 2019 Feb 13;176:74-78. Epub 2019 Feb 13.

2nd Department of Internal Medicine, Osaka Medical College, Osaka, Japan.

Background: Severe acute cholecystitis (AC) is defined by the association of organ dysfunction, including hematological dysfunction, with AC. Severe AC is often complicated by disseminated intravascular coagulation (DIC), the diagnostic criteria of which overlap with AC-associated hematological dysfunction. Since the diagnosis of DIC often delays definitive surgical management of severe AC, treatment of DIC in this setting is clinically important. Read More

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http://dx.doi.org/10.1016/j.thromres.2018.12.025DOI Listing
February 2019

Anti-adhesive effects of human soluble thrombomodulin and its domains.

Biochem Biophys Res Commun 2019 Feb 15. Epub 2019 Feb 15.

Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu-city, Mie, 514-8507, Japan.

We reported previously that leukocyte β2 integrins (LFA-1 and Mac-1) bind to the serine/threonine-rich domain of thrombomodulin (TM) expressed on vascular endothelial cells (VECs). Recombinant human soluble TM (rhsTM, TMD123) has been approved as a therapeutic drug for septic disseminated intravascular coagulation. However, the roles of TMD123 on the adhesion of leukocyte integrins to VECs remain unclear. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.02.041DOI Listing
February 2019

Fluid resuscitation with 0.9% saline alters haemostasis in an ovine model of endotoxemic shock.

Thromb Res 2019 Feb 12;176:39-45. Epub 2019 Feb 12.

Critical Care Research Group, Prince Charles Hospital, Brisbane, Australia; University of Queensland, Brisbane, Australia. Electronic address:

Introduction: Fluid resuscitation is a cornerstone of severe sepsis management, however there are many uncertainties surrounding the type and volume of fluid that is administered. The entire spectrum of coagulopathies can be seen in sepsis, from asymptomatic aberrations to fulminant disseminated intravascular coagulation (DIC). The aim of this study was to determine if fluid resuscitation with saline contributes to the haemostatic derangements in an ovine model of endotoxemic shock. Read More

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http://dx.doi.org/10.1016/j.thromres.2019.02.015DOI Listing
February 2019

A Novel Treatment for Massive Hemorrhage after Maternal Trauma in Pregnancy.

AJP Rep 2019 Jan 13;9(1):e27-e29. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, University of Arizona, Tucson, Arizona.

 Trauma in pregnancy can lead to life-threatening hemorrhage. Conventional treatments of hemorrhage include medical and surgical management. However, if these measures fail uterine compression is an option to control bleeding. Read More

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http://dx.doi.org/10.1055/s-0039-1678735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374146PMC
January 2019

Obstetrical and newborn outcomes among women with acute leukemias in pregnancy: a population-based study.

J Matern Fetal Neonatal Med 2019 Feb 17:1-7. Epub 2019 Feb 17.

a Department of Obstetrics and Gynecology , Jewish General Hospital, McGill University , Montreal , Canada.

Purpose: Acute leukemias (ALs) are rare but aggressive malignancies. The goal of our study was to determine the incidence, obstetrical, and newborn outcomes of ALs in pregnancy.

Materials And Methods: We performed a retrospective population-based cohort study on all births reported in the Health-Care Cost and Utilization Project-Nationwide Inpatient Sample between 1999 and 2014. Read More

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http://dx.doi.org/10.1080/14767058.2019.1579188DOI Listing
February 2019

Infant identical triplets' presentation of human parechovirus Type 3.

IDCases 2019 24;15:e00494. Epub 2019 Jan 24.

Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA, USA.

Introduction: Human parechovirus (HPeV) infections appear common across age groups, and transmission is likely fecal-oral and through respiratory secretions. Cyclical and seasonal patterns have been described; however, HPeV has likely been previously underdiagnosed due to lack of commercially available diagnostic testing.

Presentation Of Case: We present identical triplets contracting HPeV Type 3. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360838PMC
January 2019
1 Read

Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis.

Front Immunol 2019 31;10:55. Epub 2019 Jan 31.

Fourth Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Hemophagocytic lymphohistocytosis (HLH) is characterized by fulminant cytokine storm leading to multiple organ dysfunction and high mortality. HLH is classified into familial (fHLH) and into secondary (sHLH). fHLH is rare and it is due to mutations of genes encoding for perforin or excretory granules of natural killer (NK) cells of CD8-lymphocytes. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365431PMC
January 2019

The hot patient: acute drug-induced hyperthermia.

Aust Prescr 2019 Feb 1;42(1):24-28. Epub 2019 Feb 1.

Royal Prince Alfred Hospital, Sydney.

Drugs Can Cause Dysregulation Of The Hypothalamic–pituitary–adrenal Axis Which Can Result In A Rise In Core Temperature This Type Of Hyperthermia Is Unresponsive To Antipyretics And Can Be Complicated By Rhabdomyolysis Multi-organ Failure And Disseminated Intravascular Coagulation:

Organic Causes Of Fever Such As Infection Must Be Ruled Out Syndromes Associated With Drug-induced Fever Include Neuroleptic Malignant Syndrome And Anticholinergic Sympathomimetic And Serotonin Toxicity:

The Class Of Offending Drugs As Well As The Temporal Relationship To Starting Or Stopping Them Assists In Differentiating Between Neuroleptic Malignant Syndrome And Serotonin Toxicity:

Immediate Inpatient Management Is Needed The Mainstay Of Management Is Stopping The Drug And Supportive Care Often In The Intensive Care Unit: Read More

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https://www.nps.org.au/australian-prescriber/articles/the-ho
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http://dx.doi.org/10.18773/austprescr.2019.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370613PMC
February 2019
1 Read

Analysis of the role of thrombomodulin in all-trans retinoic acid treatment of coagulation disorders in cancer patients.

Theor Biol Med Model 2019 Feb 14;16(1). Epub 2019 Feb 14.

Department of Mechanical Engineering, University of California Santa Barbara, Santa Barbara, CA, 93106, USA.

Background: Clinical studies have shown that all-trans retinoic acid (RA), which is often used in treatment of cancer patients, improves hemostatic parameters and bleeding complications such as disseminated intravascular coagulation (DIC). However, the mechanisms underlying this improvement have yet to be elucidated. In vitro studies have reported that RA upregulates thrombomodulin (TM) expression on the endothelial cell surface. Read More

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http://dx.doi.org/10.1186/s12976-019-0099-zDOI Listing
February 2019

Severe Acquired Coagulopathy During Fulminant Sepsis Most Likely Caused by Exotoxins (SSLs).

Eur J Case Rep Intern Med 2018 27;5(12):0001002. Epub 2018 Dec 27.

Internal Medicine, Vascular Medicine, Rijnstate Hospital Arnhem, The Netherlands.

Haemostatic abnormalities frequently occur during sepsis and are most often attributed to disseminated intravascular coagulation (DIC). We report the case of a patient with severe coagulopathy acquired during fulminant sepsis. DIC was not present. Read More

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http://dx.doi.org/10.12890/2018_0001002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346979PMC
December 2018
1 Read

Fetomaternal Outcome in Eclampsia in Relationship with Gravidity.

Mymensingh Med J 2019 Jan;28(1):44-48

Dr Anonya Talukder, Junior Consultant, Department of Obs. and Gynae, Mymensingh Medical College Hospital, Mymensingh, Bangladesh.

Eclampsia is a well-recognized major cause of maternal and perinatal morbidity and mortality. Patient's age, occupational status, socioeconomic status, educational status, regular ANC (antenatal care) and gravidity may affect the outcome of mother and foetus. The purpose of this study is to see the fetomaternal outcome in eclampsia in relationship with gravidity. Read More

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January 2019
1 Read

[Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis: Rarity and Severity in an Immunocompetent Adult].

Acta Med Port 2019 Feb 1;32(1):78-80. Epub 2019 Feb 1.

Serviço de Medicina Interna. Centro Hospitalar de Trás-os-Montes e Alto Douro. Vila Real. Portugal.

Hemophagocytic lymphohistiocytosis is a rare, aggressive and life-threatening syndrome, characterized by an excessive immune activation. It is triggered by multiple stimuli, with infections having an important role. The most common infectious trigger is viral infection, particularly by Epstein-Barr virus. Read More

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http://dx.doi.org/10.20344/amp.9474DOI Listing
February 2019
1 Read

Anaphylactoid Syndrome of Pregnancy.

Nurs Womens Health 2019 Feb;23(1):38-48

Anaphylactoid syndrome of pregnancy (ASP) is a widespread, proinflammatory, anaphylactic-like reaction that can occur when amniotic fluid enters the maternal blood circulation. ASP is characterized by four cardinal findings: respiratory distress, altered mental status, hypotension, and disseminated intravascular coagulation. ASP is commonly associated with maternal and neonatal mortality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17514851183023
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http://dx.doi.org/10.1016/j.nwh.2018.11.006DOI Listing
February 2019
6 Reads

Prognostic significance of abnormal hematological parameters in severe traumatic brain injury requiring decompressive craniectomy.

J Neurosurg 2019 Feb 8:1-7. Epub 2019 Feb 8.

4Department of Neurosurgery, Royal Perth and Sir Charles Gairdner Hospitals, Perth, Western Australia, Australia.

OBJECTIVEHematological abnormalities after severe traumatic brain injury (TBI) are common, and are associated with a poor outcome. Whether these abnormalities offer additional prognostic significance over and beyond validated TBI prognostic models is uncertain.METHODSThis retrospective cohort study compared the ability of admission hematological abnormalities to that of the IMPACT (International Mission for Prognosis and Analysis of Clinical Trials) prognostic model to predict 18-month neurological outcome of 388 patients who required a decompressive craniectomy after severe TBI, between 2004 and 2016, in Western Australia. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182293DOI Listing
February 2019
1 Read

Cell Membrane-Derived Microvesicles in Systemic Inflammatory Response.

Folia Biol (Praha) 2018 ;64(4):113-124

Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Human body reacts to physical, chemical and biological insults with a complex inflammatory reaction. Crucial components and executors of this response are endothelial cells, platelets, white blood cells, plasmatic coagulation system, and complement. Endothelial injury and inflammation are associated with elevated blood levels of cell membrane-derived microvesicles. Read More

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January 2018
3 Reads

Escherichia coli Bacteremia-induced Purpura Fulminans: A Case Report.

Cureus 2018 Nov 26;10(11):e3638. Epub 2018 Nov 26.

Surgery, Riverside Community Hospital / University of California, Riverside, USA.

Purpura fulminans (PF) is a dermatologic manifestation of an underlying life-threatening condition associated with disseminated intravascular coagulation and skin necrosis. The known categories include protein C deficiency or abnormalities of other coagulation systems (inherited or acquired), acute infectious PF and idiopathic. We describe a case of PF induced by associated bacteremia. Read More

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http://dx.doi.org/10.7759/cureus.3638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351005PMC
November 2018
8 Reads

Fibrin Modulates Shear-Induced NETosis in Sterile Occlusive Thrombi Formed under Haemodynamic Flow.

Thromb Haemost 2019 Feb 5. Epub 2019 Feb 5.

Department of Chemical and Biomolecular Engineering, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States.

Neutrophils can release extracellular traps (NETs) in infectious, inflammatory and thrombotic diseases. NETs have been detected in deep vein thrombosis, atherothrombosis, stroke, disseminated intravascular coagulation and trauma. We have previously shown that haemodynamic forces trigger rapid NETosis within sterile occlusive thrombi in vitro. Read More

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http://dx.doi.org/10.1055/s-0039-1678529DOI Listing
February 2019
1 Read

Sudden elevation of plasma D-dimer levels induced by the combination therapy of dabrafenib and trametinib: Report of two cases.

J Dermatol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, St Marianna University School of Medicine, Kawasaki, Japan.

The combination therapy of dabrafenib and trametinib revolutionized the treatment for BRAF V600-mutated melanoma. Various adverse events have been reported for this treatment, most notably fever. Herein, we report two cases of novel an adverse event, namely sudden and significant elevation of plasma D-dimer level induced by this therapy. Read More

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http://dx.doi.org/10.1111/1346-8138.14798DOI Listing
February 2019
1 Read

Successful surgical management of non-perforating acute appendicitis with septic disseminated intravascular coagulation: A case report and review of the literature.

Int J Surg Case Rep 2019 Jan 29;55:103-106. Epub 2019 Jan 29.

Department of Gastroenterological Surgery, Hiroshima City Asa Citizens Hospital, Japan.

Introduction: Perforating appendicitis and abscess-forming appendicitis may cause septic disseminated intravascular coagulation (DIC). However, non-perforating acute appendicitis with septic DIC is extremely rare.

Presentation Of Case: A 67-year-old man was referred to our hospital one day after starting oral antibiotic treatment for acute appendicitis. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360458PMC
January 2019
1 Read

Repeat dose exposure of PM triggers the disseminated intravascular coagulation (DIC) in SD rats.

Sci Total Environ 2019 Jan 28;663:245-253. Epub 2019 Jan 28.

Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China. Electronic address:

Epidemiological evidence suggests that fine particulate matter (PM) in air pollution promotes the formation of deep venous thrombosis. However, no evidence is available on the effects of PM lead to disseminated intravascular coagulation (DIC). For the first time, this study explored the effects of PM on DIC via coagulation disorders in vivo. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.346DOI Listing
January 2019
2 Reads

[Intrarenal lesions of disseminated intravascular coagulation (DIC)].

Ann Pathol 2019 Jan 28. Epub 2019 Jan 28.

Service de pathologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France; Inserm, U728, 75010 Paris, France; Institut universitaire d'hématologie, université Paris-Diderot, Paris-7, 75010 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.annpat.2018.12.004DOI Listing
January 2019
1 Read

Group A streptococcus endocarditis in children: 2 cases and a review of the literature.

BMC Infect Dis 2019 Jan 31;19(1):102. Epub 2019 Jan 31.

Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, Department of General Pediatrics, Okinawa, Japan.

Background: Infective endocarditis (IE) is defined as endocarditis caused by microorganisms (bacteria or fungi) involving either the heart or great vessels. The clinical course of IE can be complicated by cardiac dysfunction and bacterial embolization to virtually any organ. Staphylococcus aureus and viridans group streptococci are the most common causative organisms, whereas group A Streptococcus (GAS) is less common. Read More

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http://dx.doi.org/10.1186/s12879-019-3736-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357504PMC
January 2019
2 Reads

Acute fibrinolysis shutdown occurs early in septic shock and is associated with increased morbidity and mortality: results of an observational pilot study.

Ann Intensive Care 2019 Jan 30;9(1):19. Epub 2019 Jan 30.

Department of Anesthesiology, Heidelberg University Hospital, 110, Im Neuenheimer Feld, 69120, Heidelberg, Germany.

Background: Septic coagulopathy represents a very dynamic disease entity, tilting from initial hypercoagulability towards a subsequent hypocoagulable disease state, entitled overt disseminated intravascular coagulation. Acute fibrinolysis shutdown has recently been described to be a crucial component of initial hypercoagulability in critically ill patients, although the underlying pathomechanisms, the specific temporal kinetics and its outcome relevance in patients with sepsis remain to be determined.

Methods: In total, 90 patients (30 with septic shock, 30 surgical controls and 30 healthy volunteers) were enrolled. Read More

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http://dx.doi.org/10.1186/s13613-019-0499-6DOI Listing
January 2019
2 Reads

Heads up: don't forget the ordinary.

Oxf Med Case Reports 2019 Jan 24;2019(1):omy117. Epub 2019 Jan 24.

Department of Medicine, Warren Alpert Medical School, Brown University, Providence, RI, USA.

A 72-year-old woman presented to the emergency department with shortness of breath, diffuse swelling and a haemoglobin of 4.2 g/dl. Her history was notable for an unusual necrotic occipital neck mass that had begun to enlarge and intermittently bleed over the past year. Read More

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http://dx.doi.org/10.1093/omcr/omy117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345085PMC
January 2019
2 Reads

Plasma Fibrinogen and D-dimer in Children With Sepsis: A Single-Center Experience.

Iran J Pathol 2018 17;13(2):272-275. Epub 2018 Jul 17.

Dept. of Pathology, University College of Medical Sciences, Delhi, India.

Background & Objective: In sepsis, enhanced fibrin formation, impaired fibrin degradation, and intravascular fibrin deposition lead to a prothrombotic state. The current study aimed at measuring various coagulation parameters to predict an early marker for disseminated intravascular coagulation(DIC).

Methods: The current prospective study was conducted from January 2012 to April 2013 on 50 children aged 1-10 years with clinically suspected sepsis referred to the Department of Pediatrics of a tertiary care center in New Delhi, India. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339482PMC
July 2018
6 Reads

D-dimer: Preanalytical, analytical, postanalytical variables, and clinical applications.

Crit Rev Clin Lab Sci 2018 Dec;55(8):548-577

a CHU UCL Namur, Namur Thrombosis and Hemostasis Center, Hematology Laboratory , Université Catholique de Louvain , Yvoir , Belgium.

D-dimer is a soluble fibrin degradation product deriving from the plasmin-mediated degradation of cross-linked fibrin. D-dimer can hence be considered a biomarker of activation of coagulation and fibrinolysis, and it is routinely used for ruling out venous thromboembolism (VTE). D-dimer is increasingly used to assess the risk of VTE recurrence and to help define the optimal duration of anticoagulation treatment in patients with VTE, for diagnosing disseminated intravascular coagulation, and for screening medical patients at increased risk of VTE. Read More

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http://dx.doi.org/10.1080/10408363.2018.1529734DOI Listing
December 2018
2 Reads

Early pathology in venom-induced consumption coagulopathy by Rhabdophis tigrinus (Yamakagashi snake) envenomation.

Clin Toxicol (Phila) 2019 Jan 28:1-4. Epub 2019 Jan 28.

e Department of Dermatology, Graduate School of Medical Science , Kyushu University , Fukuoka , Japan.

Objective: Rhabdophis tigrinus (Yamakagashi in Japanese) is a venomous non-front-fanged colubroid snake capable of inflicting envenoming with life-threatening defibrinating coagulopathy. However, because of the uncommon incidence of bites and tendency for late development of symptoms/signs, the early effects of the venom on the coagulation system are poorly known.

Case Report: We describe a boy bitten by a wild R. Read More

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http://dx.doi.org/10.1080/15563650.2018.1540045DOI Listing
January 2019
2 Reads

A case report of a child with sepsis induced multiorgan failure and massive complement consumption treated with a short course of Eculizumab: A case of crosstalk between coagulation and complement?

Medicine (Baltimore) 2019 Jan;98(4):e14105

University Hospital Centre Zagreb, Kispaticeva, Zagreb.

Rationale: This article describes a child with a life-threatening multiorgan failure with disseminated intravascular coagulation (DIC) and massive complement consumption. To our knowledge this therapeutic approach was for the first time effectively applied in a pediatric patient.

Patient Concerns: A 14-month-old boy was presented with a severe, rapidly progressing, life-threatening disease because of sudden onset of fever, hemathemesis, hematuria, and bloody diarrhoea alongside fast spreading hematomas and general corporeal edema. Read More

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http://dx.doi.org/10.1097/MD.0000000000014105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358330PMC
January 2019
2 Reads

Effect of continuous venovenous haemodialysis on outcome and pharmacokinetics of arsenic species in a patient with acute promyelocytic leukaemia and acute kidney injury.

Br J Clin Pharmacol 2019 Jan 24. Epub 2019 Jan 24.

Department of Pharmacy, the First Hospital, Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, 150001, China.

This study presents outcome and pharmacokinetics of arsenic trioxide (ATO) metabolites in patients on continuous venovenous haemodialysis (CVVHD). Of 3 acute promyelocytic leukaemia patients receiving CVVHD in management of acute kidney injury, only 1 patient was included. The patient presented disseminated intravascular coagulation and acute kidney injury before induction therapy was conducted. Read More

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http://doi.wiley.com/10.1111/bcp.13875
Publisher Site
http://dx.doi.org/10.1111/bcp.13875DOI Listing
January 2019
19 Reads

Successful treatment for disseminated intravascular coagulation (DIC) corresponding to phenotype changes in a heat stroke patient.

J Intensive Care 2019 15;7. Epub 2019 Jan 15.

Graduate School of Medicine, Department of Emergency and Critical Care Medicine, Ehime University, Shitsukawa 454, Toon, Ehime 791-0295 Japan.

Background: Heat stroke induces coagulofibrinolytic activation, which leads to life-threatening disseminated intravascular coagulation (DIC). However, treatment strategies for DIC in heat stroke have not yet been established, and also, the time course changes in coagulofibrinolytic markers have not been thoroughly evaluated. We report a severe heat stroke case with DIC who was eventually saved by anti-DIC treatments in accordance with changes in coagulofibrinolytic markers. Read More

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http://dx.doi.org/10.1186/s40560-019-0359-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332900PMC
January 2019
3 Reads

Management of Symmetrical Peripheral Gangrene.

Indian J Crit Care Med 2018 Dec;22(12):870-874

Department of Surgery, School of Medicine, Perdana University-Royal College of Surgeons Ireland Selangor, Malaysia.

Symmetrical peripheral gangrene (SPG) is a rare, debilitating disease that deserves more widespread concern among the medical fraternities. The objective of this review is to outline the etiology, pathology findings, and management practices of SPG. About 18%-40% mortality rate was reported, and survivors have high frequency of multiple limb amputations. Read More

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http://dx.doi.org/10.4103/ijccm.IJCCM_379_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311972PMC
December 2018
5 Reads

Coagulation Derangements in Patients With Refractory Cardiac Arrest Treated With Extracorporeal Cardiopulmonary Resuscitation.

J Cardiothorac Vasc Anesth 2018 Nov 14. Epub 2018 Nov 14.

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy. Electronic address:

Objective: Extracorporeal cardiopulmonary resuscitation (eCPR) with venoarterial extracorporeal membrane oxygenation (VA-ECMO) is gaining importance as a rescue therapy for refractory cardiac arrest. VA-ECMO, especially in the setting of eCPR, is plagued by hemorrhagic and thromboembolic complications. The authors' aims were to describe the coagulation profile in refractory cardiac arrest and assess its prognostic role. Read More

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http://dx.doi.org/10.1053/j.jvca.2018.11.014DOI Listing
November 2018
2 Reads

Endogenous genetic risk factor for serious heatstroke: the thermolabile phenotype of carnitine palmitoyltransferase II variant.

Acute Med Surg 2019 Jan 1;6(1):25-29. Epub 2018 Oct 1.

Division of Enzyme Chemistry Institute for Enzyme Research Tokushima University Tokushima Japan.

Aim: In serious heatstroke, elevated body temperature (>40°C) is considered the main cause of illness. Mitochondrial carnitine palmitoyltransferase II (CPT II) plays an important role in adenosine triphosphate (ATP) generation from long-chain fatty acids, and its thermolabile phenotype of polymorphisms leads to ATP production loss under high fever. Whether by heatstroke or influenza, high fever suppresses mitochondrial ATP production in patients with the thermolabile phenotype of polymorphisms. Read More

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http://dx.doi.org/10.1002/ams2.373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328901PMC
January 2019
3 Reads

Oh, how hard it is to open the gate for sepsis trials: lessons from SCARLET.

Acute Med Surg 2019 Jan 22;6(1):3-4. Epub 2018 Nov 22.

Department of Emergency and Critical Care Medicine Juntendo University Graduate School of Medicine Urayasu Hospital Chiba Japan.

Although SCARLET could not achieve its primary end-point, the conditions of this trial were different from that of clinical practice in Japan. The effectiveness of the anticoagulant therapy for septic disseminated intravascular coagulation should be examined further in future studies. Read More

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http://doi.wiley.com/10.1002/ams2.372
Publisher Site
http://dx.doi.org/10.1002/ams2.372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328919PMC
January 2019
4 Reads

The Elusive Diagnosis of Disseminated Intravascular Coagulation: Does a Diagnosis of DIC Exist Anymore?

Authors:
Jecko Thachil

Semin Thromb Hemost 2019 Feb 11;45(1):100-107. Epub 2019 Jan 11.

Department of Haematology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.

Disseminated intravascular coagulation (DIC) is an intermediary mechanism of disease known to develop as a complication in other conditions like sepsis, trauma, cancer, or obstetrical disorders. Patients with DIC may present to different specialists depending on symptomology and as such a good understanding of the pathophysiological process is necessary to ensure best management. However, more recently, controversy has risen where experts doubt whether DIC really exists in many of the historically well-established diagnoses. Read More

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http://dx.doi.org/10.1055/s-0038-1677042DOI Listing
February 2019
2 Reads

Blood coagulation: a powerful bactericidal mechanism of human innate immunity.

Int Rev Immunol 2019 Jan 11:1-15. Epub 2019 Jan 11.

b Hospital Longlern , Gottingen , Germany.

Infection proliferates and disseminates rapidly and so innate immunity should react effectively and fast. Innate immunity mechanisms depend upon fluid dynamics and are different in compartments with slow (the tissues) and rapid (the bloodstream) liquid flow. In the tissues, coagulation initiated by clotting factors, platelets and erythrocytes, is prompt and effective mechanism of the first line of antibacterial defense. Read More

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http://dx.doi.org/10.1080/08830185.2018.1533009DOI Listing
January 2019
2 Reads

An evidence-based narrative review of the emergency department evaluation and management of rhabdomyolysis.

Am J Emerg Med 2019 Jan 2. Epub 2019 Jan 2.

Department of Emergency Medicine, Rush University Medical Center, United States.

Background: Rhabdomyolysis is a medical condition caused by muscle breakdown leading to potential renal damage. This can result in significant morbidity and mortality if not rapidly identified and treated.

Objective: This article provides an evidence-based narrative review of the diagnosis and management of rhabdomyolysis, with focused updates for the emergency clinician. Read More

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http://dx.doi.org/10.1016/j.ajem.2018.12.061DOI Listing
January 2019
2 Reads

How to Optimize Activated Partial Thromboplastin Time (APTT) Testing: Solutions to Establishing and Verifying Normal Reference Intervals and Assessing APTT Reagents for Sensitivity to Heparin, Lupus Anticoagulant, and Clotting Factors.

Semin Thromb Hemost 2019 Feb 10;45(1):22-35. Epub 2019 Jan 10.

Department of Haematology, NSW Health Pathology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

The activated partial thromboplastin time (APTT) assay is a very common coagulation test, used for several reasons. The test is conventionally used for assessing the contact factor (intrinsic) pathway of blood coagulation, and thus for screening deficiencies in this pathway, most typically factors VIII, IX, and XI. The APTT is also sensitive to contact factor deficiencies, including factor XII, prekallikrein, and high-molecular-weight kininogen. Read More

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http://dx.doi.org/10.1055/s-0038-1677018DOI Listing
February 2019
5 Reads

[Young adult myelodysplastic syndrome with central nervous system involvement diagnosed following cerebral embolism].

Rinsho Ketsueki 2018 ;59(12):2583-2587

Division of Hematology, Shonan Kamakura General Hospital.

While acute myeloid leukemia (AML) could cause an invasion of the central nervous system (CNS), the invasion of the CNS in myelodysplastic syndrome (MDS) is rare. Here, we report a case of juvenile MDS with cerebral infarction concerning the invasion of the CNS by leukemia cells. A 25-year-old male was admitted to our institution because of difficulty in extending the left arm. Read More

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http://dx.doi.org/10.11406/rinketsu.59.2583DOI Listing
January 2018
2 Reads

[Significance of monitoring cerebrospinal fluid leukocyte counts in managing central nervous system disease of acute myeloid leukemia in patients presenting with intracerebral hemorrhage upon initial examination].

Rinsho Ketsueki 2018 ;59(12):2578-2582

Department of Medicine (Division of Hematology), Shiga University of Medical Science.

A 17-year-old woman was urgently transported to our hospital due to consciousness disturbance. A blood examination revealed intracerebral hemorrhage, WBC 233,800/l, blasts 93%, and disseminated intravascular coagulation. The results of bone-marrow aspiration indicated acute myeloid leukemia (M2 in FAB classification) with t (7;11) (p15;p15) and the resulting chimeric gene NUP98-HOXA9 and with FLT3-ITD. Read More

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https://www.jstage.jst.go.jp/article/rinketsu/59/12/59_2578/
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http://dx.doi.org/10.11406/rinketsu.59.2578DOI Listing
January 2018
8 Reads

Microvascular Thrombosis and Ischaemic Limb Losses in Critically Ill Patients.

Hamostaseologie 2019 Feb 9;39(1):6-19. Epub 2019 Jan 9.

Department of Pathology and Molecular Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

Relatively little scientific attention has been given to the small subset of critically ill patients with circulatory shock who develop ischaemic limb losses (symmetrical peripheral gangrene [SPG]). The clinical picture consists of acral (distal extremity) tissue necrosis involving lower limbs in a largely symmetrical fashion and with detectable arterial pulses; in one-third of patients the upper extremities are also affected (potential for four-limb amputations). The laboratory picture includes thrombocytopenia, coagulopathy, and normoblastemia (circulating nucleated red blood cells). Read More

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http://dx.doi.org/10.1055/s-0038-1676823DOI Listing
February 2019
4 Reads

Hepatic portal venous gas related to appendicitis.

J Surg Case Rep 2018 Dec 26;2018(12):rjy333. Epub 2018 Dec 26.

Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Japan.

Background: Hepatic portal venous gas (HPVG) is rare with high mortality. There are few reports on HPVG's association with appendicitis. Here we report a case of HPVG associated with appendicitis. Read More

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https://academic.oup.com/jscr/article/doi/10.1093/jscr/rjy33
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http://dx.doi.org/10.1093/jscr/rjy333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305834PMC
December 2018
11 Reads

Differential diagnoses for sepsis-induced disseminated intravascular coagulation: communication from the SSC of the ISTH.

J Thromb Haemost 2019 Feb 7;17(2):415-419. Epub 2019 Jan 7.

Department of Medicine, University College London Hospitals NHS Foundation Trust, London, UK.

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http://doi.wiley.com/10.1111/jth.14354
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http://dx.doi.org/10.1111/jth.14354DOI Listing
February 2019
9 Reads

The evaluation of hemostatic dysfunction and disseminated intravascular coagulation in dairy cows with abomasal displacement.

Pol J Vet Sci 2018 Dec;21(4):769-778

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Selcuk University, 42003, Konya, Turkey.

Disseminated intravascular coagulation (DIC) is a complex, dynamic and hemostatic disorder which develops secondarily to a disease characterized with an imbalance in the pro-coagulant and anti-coagulant components of hemostasis. The aim of the study is to evaluate hemostatic dysfunc- tion and the DIC syndrome in cattle with displaced abomasum (DA), with using the hematologic analyses and an extensive coagulation profile in the 96 hour-period including before and after surgery. The animal material of the study consisted of 12 dairy cows diagnosed with displaced abomasum (9 LDA and 3 RDA without volvulus) in the 2-4 week period after parturation and with no other post-partum disease. Read More

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http://dx.doi.org/10.24425/pjvs.2018.125590DOI Listing
December 2018
2 Reads

An autopsy case of primary extranodal NK/T cell lymphoma (extranodal NK/T-cell lymphoma) of the bile duct.

Clin J Gastroenterol 2019 Jan 2. Epub 2019 Jan 2.

Department of Gastroenterology, Tokai University Hachioji Hospital, Tokyo, Japan.

We reported the case of a 50-year-old man diagnosed with extrinsic NK/T-cell lymphoma. He was initially diagnosed with locally advanced unresected pancreatic duct carcinoma and was treated with combination chemotherapy using gemcitabine and nabpaclitaxel. One month after treatment, he developed bleeding. Read More

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http://link.springer.com/10.1007/s12328-018-00931-1
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http://dx.doi.org/10.1007/s12328-018-00931-1DOI Listing
January 2019
10 Reads

The reduced form of coagulation factor XI is associated with illness severity and coagulopathy in critically-ill septic patients.

J Thromb Thrombolysis 2019 Jan 2. Epub 2019 Jan 2.

Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.

Coagulation Factor XI (FXI) contributes to the pathobiology of sepsis-associated thrombosis and is a target for new therapeutics. Through cleavage of disulfide bonds, FXI becomes reduced (rFXI), accelerating intrinsic coagulation cascade activation. The role of rFXI in human sepsis has never been studied. Read More

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http://dx.doi.org/10.1007/s11239-018-1797-9DOI Listing
January 2019
4 Reads

Intensive care unit complications and outcomes of adult patients with hemophagocytic lymphohistiocytosis: A retrospective study of 16 cases.

World J Crit Care Med 2018 Nov 30;7(6):73-83. Epub 2018 Nov 30.

Department of Pulmonary, Critical Care and Sleep, Baylor College of Medicine, Houston, TX 77030, United States.

Aim: To study the management, complications and outcomes of adult patients admitted with hemophagocytic lymphohistiocytosis (HLH) in the intensive care unit (ICU).

Methods: We performed a retrospective observational study of adult patients with the diagnosis of "HLH" admitted to the two academic medical ICUs of Baylor College of Medicine between 01/01/2013 to 06/30/2017. HLH was diagnosed using the HLH-2004 criteria proposed by the Histiocyte Society. Read More

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http://dx.doi.org/10.5492/wjccm.v7.i6.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305525PMC
November 2018
2 Reads

The roles of activated protein C in experimental trauma models.

Chin J Traumatol 2018 Dec 11;21(6):311-315. Epub 2018 Dec 11.

Department of Social Medicine, Graduate School of Medicine, Osaka University, Japan.

Trauma-induced coagulopathy is classified into primary and secondary coagulopathy, with the former elicited by trauma and traumatic shock itself and the latter being acquired coagulopathy induced by anemia, hypothermia, acidosis, and dilution. Primary coagulopathy consists of disseminated intravascular coagulation and acute coagulopathy of trauma shock (ACOTS). The pathophysiology of ACOTS is the suppression of thrombin generation and neutralization of plasminogen activator inhibitor-1 mediated by activated protein C that leads to hypocoagulation and hyperfibrinolysis in the circulation. Read More

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http://dx.doi.org/10.1016/j.cjtee.2018.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354177PMC
December 2018
2 Reads

Feasibility, safety, and short-term outcome of totally thoracoscopic mitral valve procedure.

J Cardiothorac Surg 2018 Dec 29;13(1):133. Epub 2018 Dec 29.

Department of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.

Background: The totally thoracoscopic procedure for mitral valve (MV) disease is a minimally invasive method. We investigated the procedure's feasibility, safety and effectiveness when it was performed by an experienced operator.

Methods: We retrospectively analysed 53 consecutive patients with MV disease treated between December 2014 and April 2017 by minimally invasive procedures. Read More

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http://dx.doi.org/10.1186/s13019-018-0819-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310972PMC
December 2018
9 Reads

External Validation of the Two Newly Proposed Criteria for Assessing Coagulopathy in Sepsis.

Thromb Haemost 2019 Feb 28;119(2):203-212. Epub 2018 Dec 28.

Division of Trauma and Surgical Critical Care, Osaka General Medical Center, Osaka, Japan.

Background:  Two different criteria for evaluating coagulopathy in sepsis were recently released: sepsis-induced coagulopathy (SIC) and sepsis-associated coagulopathy (SAC). Although both use universal haemostatic markers of platelet count and pro-thrombin time, significance and usefulness of these criteria remain unclear.

Objective:  This article validates and evaluates the significance of SIC and SAC criteria compared with the International Society on Thrombosis and Haemostasis (ISTH) overt disseminated intravascular coagulation (DIC) and Japanese Association for Acute Medicine (JAAM) DIC criteria. Read More

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http://dx.doi.org/10.1055/s-0038-1676610DOI Listing
February 2019
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