62,259 results match your criteria Disseminated Intravascular Coagulation


Antibiotic-resistant clones in Gram-negative pathogens: presence of global clones in Korea.

Authors:
Kwan Soo Ko

J Microbiol 2018 Oct 2. Epub 2018 Oct 2.

Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, 16419, Republic of Korea.

Antibiotic resistance is a global concern in public health. Antibiotic-resistant clones can spread nationally, internationally, and globally. This review considers representative antibiotic-resistant Gram-negative bacterial clones-CTX-M- 15-producing ST131 in Escherichia coli, extended-spectrum β-lactamase-producing ST11 and KPC-producing ST258 in Klebsiella pneumoniae, IMP-6-producing, carbapenem-resistant ST235 in Pseudomonas aeruginosa, and OXA-23-producing global clone 2 in Acinetobacter baumannii-that have disseminated worldwide, including in Korea. Read More

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October 2018

Fulminant mucormycosis after a traffic accident: a case report.

Folia Microbiol (Praha) 2018 Dec 14. Epub 2018 Dec 14.

Department of Microbiology, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 9 M. Sklodowska-Curie Street, 85-094, Bydgoszcz, Poland.

Mucormycosis is a rare fungal infection in immunocompetent patients, whereas in immunocompromised, it may be systemic and disseminated infection associated with high mortality. Mucormycosis is one of the most rapidly progressing and fulminant forms of fungal infections; Mucor circinelloides is rarely isolated species, also from immunocompromised patients. The reported case of mucormycosis after a traffic accident indicates that it may be the result of a contamination of wound by M. Read More

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December 2018

Dexamethasone versus prednisone for children receiving asthma treatment in the paediatric inpatient population: protocol for a feasibility randomised controlled trial.

BMJ Open 2018 Dec 14;8(12):e025630. Epub 2018 Dec 14.

Departments of Pediatrics and Emergency Medicine, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada.

Introduction: Asthma exacerbations are a leading cause of paediatric hospitalisations. Corticosteroids are key in the treatment of asthma exacerbations. Most current corticosteroids treatment regimens for children admitted with asthma exacerbation consist of a 5-day course of prednisone or prednisolone. Read More

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December 2018

Effectiveness of self-testing kits availability on improving HIV testing frequency for chinese men who have sex with men and their sexual partners: a protocol for a multicenter randomised controlled trial.

BMJ Open 2018 Dec 14;8(12):e024423. Epub 2018 Dec 14.

Xiangya Nursing School of Central South University, Changsha, China.

Introduction: HIV epidemic is increasing among men who have sex with men (MSM) in China, yet HIV testing uptake remains low. As an emerging approach, HIV self-testing (HIVST) has the potential to promote HIV testing coverage and frequency in this population. However, evidence of the effectiveness on implementation of HIVST among Chinese MSM and their sexual partners is scarce. Read More

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December 2018

Vascular and cognitive effects of cocoa-rich chocolate in postmenopausal women: a study protocol for a randomised clinical trial.

BMJ Open 2018 Dec 14;8(12):e024095. Epub 2018 Dec 14.

Primary Health Care Research Unit, La Alamedilla Health Center, Institute of Biomedical Research of Salamanca (IBSAL), Health Service of Castilla y León (SACyL), Salamanca, Spain.

Introduction: The intake of polyphenols has certain health benefits. This study will aim to assess the effect of adding a daily amount of chocolate high in cocoa content and polyphenols to the normal diet on blood pressure, vascular function, cognitive performance, quality of life and body composition in postmenopausal women.

Methods And Analysis: Here we plan a randomised clinical trial with two parallel groups involving a total of 140 women between 50 and 64 years in the postmenopausal period, defined by amenorrhoea of ​​at least 12 consecutive months. Read More

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December 2018

Rationale and design of a single-blind, randomised controlled trial of exercise training for managing learning and memory impairment in persons with multiple sclerosis.

BMJ Open 2018 Dec 14;8(12):e023231. Epub 2018 Dec 14.

Kessler Foundation, Neuropsychology and Neuroscience Research, West Orange, New Jersey, USA.

Introduction: This randomised controlled trial (RCT) examines treadmill walking exercise training effects on learning and memory performance, hippocampal volume, and hippocampal resting-state functional connectivity in persons with multiple sclerosis (MS) who have objective impairments in learning new information.

Methods And Analysis: Forty fully ambulatory persons with MS who demonstrate objective learning and memory impairments will be randomly assigned into either the intervention or active control study conditions. The intervention condition involves supervised, progressive treadmill walking exercise training three times per week for a 3-month period. Read More

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December 2018

Study protocol for a double-blind randomised controlled trial investigating the impact of 12 weeks supplementation with a extract on cholesterol levels in adults with elevated fasting LDL cholesterol who are overweight or have obesity.

BMJ Open 2018 Dec 14;8(12):e022195. Epub 2018 Dec 14.

Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, Victoria, Australia.

Introduction: Hyperlipidaemia, hyperglycaemia and chronic inflammation are risk factors for chronic diseases cardiovascular disease and type 2 diabetes. Polyphenols are bioactive compounds found in marine algae with potential antihyperlipidaemic, antihyperglycaemic and anti-inflammatory effects. The modulation of these risk factors using bioactive polyphenols may represent a useful strategy for disease prevention and management; research in humans, however, remains limited. Read More

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December 2018
1 Read

Indigenous health worker support for patients with poorly controlled type 2 diabetes: study protocol for a cluster randomised controlled trial of the Mana Tū programme.

BMJ Open 2018 Dec 14;8(12):e019572. Epub 2018 Dec 14.

Te Kupenga Hauora Māori, University of Auckland, Auckland, New Zealand.

Introduction: Type 2 diabetes mellitus (T2DM) and its complications are more common among Māori and Pacific people compared with other ethnic groups in New Zealand. Comprehensive and sustained approaches that address social determinants of health are required to address this condition, including culturally specific interventions. Currently, New Zealand has no comprehensive T2DM management programme for Māori or Pacific people. Read More

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December 2018

Pancreatic carcinoma underlying a complex presentation in late pregnancy: a case report.

J Med Case Rep 2018 Dec 15;12(1):369. Epub 2018 Dec 15.

Department of Maternal-Fetal Medicine Pregnancy Research Centre, Royal Women's Hospital, Parkville, Australia.

Background: Gestational diabetes mellitus is strongly related to the risk of pancreatic cancer in pregnant women, but gestational diabetes can precede a diagnosis of pancreatic cancer by many years. Women with a history of gestational diabetes showed a relative risk of pancreatic cancer of 7.1. Read More

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December 2018

Premature diagnosis of calciphylaxis without pathological indications finally diagnosed as cutaneous small-vessel vasculitis: a post-mortem case report.

Nihon Jinzo Gakkai Shi 2017 ;59(2):85-91

A man in his fifties with diabetes had a past history of myocardial infarction and ventricular septal perforation. He underwent hemodialysis about a year ago and was taking amiodarone. He presented with sores and purpura on the lower limbs. Read More

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January 2017
1 Read

Development of Mafutsusan by Seishu Hanaoka and General Anesthetics in the Very Early Part of the 19th Century in Japan.

Authors:
Akitomo Matsuki

Nihon Ishigaku Zasshi 2016 Dec;62(4):413-428

Seishu Hanaoka's medicine is famed for its breast cancer surgery. Hanaoka, who,was motivated by Dokushoan Nagatomi's Man-yu zakki, published in 1771, had the idea to excise a breast cancer tumor and not to perform a breast amputation. Because he recognized that general anesthesia was indispensable for performing a surgical operation of the breast, he developed a general anesthetic and surmounted various difficulties: selection of an anesthetic method, anesthetic ingredients, determination of the opti- mal dosage, administration methods, indications and contra-indications, evaluation of the depth of anesthesia, facilitation of the smooth emergence from anesthesia, and postoperative care. Read More

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December 2016

Effect of Macrolide Prophylactic Therapy on AIDS-Defining Conditions and HIV-Associated Mortality.

J Acquir Immune Defic Syndr 2018 Dec 10. Epub 2018 Dec 10.

Research Institute for Tropical Medicine, Muntinlupa City, Philippines.

Background: Mycobacterium avium complex (MAC) prophylaxis is recommended for patients with advanced HIV infection. With the decrease in incidence of disseminated MAC infection and the availability of antiretroviral therapy (ART), the benefits of macrolide prophylaxis were investigated. This study examined the impact of macrolide prophylaxis on AIDS-defining conditions and HIV-associated mortality in a cohort of HIV-infected patients on ART. Read More

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December 2018

Cloning of carrier cells infected with oncolytic adenovirus driven by midkine promoter and biosafety studies.

J Gene Med 2018 Dec 13:e3064. Epub 2018 Dec 13.

Department of Obstetrics and Gynecology, School of Medicine, Ehime University, Ehime, Japan.

Background: A549 carrier cells infected with oncolytic adenovirus can induce complete tumor reduction of subcutaneous ovarian tumors but not intraperitoneal disseminated ovarian tumors. This seems to be due to the insufficient antitumor effect of A549 carrier cells. Therefore, here we cloned a novel carrier cell with the aim of improving antitumor effects. Read More

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December 2018
1 Read

Evidence of promoting prevention and the early detection of breast cancer among women, a hospital-based education and screening interventions in low- and middle-income countries: a systematic review protocol.

Syst Rev 2018 Dec 14;7(1):234. Epub 2018 Dec 14.

Discipline of Nursing, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, 4001, South Africa.

Background: Given the increasing burden of breast cancer in the low- and middle-income countries, cost-effective approaches are needed to improve the early detection of breast cancer in these continents. Global policies and guidelines are now placing much emphasis on promoting early detection of breast cancer through integrated education and screening interventions. The proposed systematic review aims to map evidence on hospital-based breast cancer education, breast self-examination, and clinical breast examination services for women in low- and middle-income countries. Read More

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December 2018

Characterization of Mycobacterium tuberculosis strains in Beijing, China: drug susceptibility phenotypes and Beijing genotype family transmission.

BMC Infect Dis 2018 Dec 14;18(1):658. Epub 2018 Dec 14.

Department of Bacteriology and Immunology, Beijing Key Laboratory on Drug-Resistant Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute/Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China.

Background: The most prevalent strains of Mycobacterium tuberculosis (M.tb) in Beijing belong to the Beijing genotype family. The influence of Beijing genotype prevalence on the development of drug resistance, and the association of infection with Beijing genotype M. Read More

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December 2018

Effectiveness of repellent delivered through village health volunteers on malaria incidence in villages in South-East Myanmar: a stepped-wedge cluster-randomised controlled trial protocol.

BMC Infect Dis 2018 Dec 14;18(1):663. Epub 2018 Dec 14.

Burnet Institute, Melbourne, Australia.

Background: To combat emerging drug resistance in the Greater Mekong Sub-region (GMS) the World Health Organization and GMS countries have committed to eliminating malaria in the region by 2030. The overall approach includes providing universal access to diagnosis and treatment of malaria, and sustainable preventive measures, including vector control. Topical repellents are an intervention that can be used to target residual malaria transmission not covered by long lasting insecticide nets and indoor residual spraying. Read More

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December 2018

Skeletal evidence of probable treponemal infection in free-ranging African apes.

Primates 2000 Jul;41(3):275-290

Department of Anthropology, Colorado State University, 80523, Ft. Collins, Colorado, U. S. A.

The prevalence and patterning of inflammatory lesions of the skeleton were investigated in samples of chimpanzees (Pan troglodytes troglodytes) and gorillas (Gorilla gorilla gorilla) curated at the Powell-Cotton Museum, Birchington, UK. One hundred and two chimpanzees (42 adults and 60 subadults) and 126 gorillas (50 adults and 76 subadults) comprise the samples. Twenty per cent of chimpanzees and 14% of gorillas were affected with a disseminated inflammatory skeletal condition caused by infection. Read More

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Successful treatment of disseminated intravascular coagulation associated with aortic dissection.

J Vasc Surg Cases Innov Tech 2018 Dec 4;4(4):268-271. Epub 2018 Dec 4.

Division of Cardiovascular Surgery, Narita Red Cross Hospital, Chiba, Japan.

Disseminated intravascular coagulation (DIC) is an infrequent aortic dissection complication, and its optimal treatment remains controversial. A 55-year-old woman developed DIC associated with Stanford type B aortic dissection, which improved by administration of low-molecular-weight heparin combined with tranexamic acid, but the dissecting aneurysm of the descending aorta was dilated. After thoracic endovascular aortic repair for occlusion of entry tears detected by transesophageal echocardiography, DIC improved without anticoagulant therapy. Read More

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December 2018
1 Read

Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer.

Oncogene 2018 Dec 13. Epub 2018 Dec 13.

Pathology Unit, Department of Oncology, Microbiology and Immunology (OMI), Faculty of Science and Medicine, University of Fribourg, 1700, Fribourg, Switzerland.

Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however, there is no formal evidence for it. Here, we provide experimental evidence that ER breast cancer cells that survived high-dose Doxorubicin and Methotrexate based chemotherapies elicit a state of immunological dormancy. Read More

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December 2018

Treating invasive aspergillosis in patients with hematologic malignancy: diagnostic-driven approach versus empiric therapies.

BMC Infect Dis 2018 Dec 13;18(1):656. Epub 2018 Dec 13.

Department of Infectious Diseases, Infection Control & Employee Health, Unit 1460, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA.

Background: Early antifungal therapy for invasive aspergillosis (IA) has been associated with improved outcome. Traditionally, of empiric antifungal therapy has been used for clinically suspected IA. We compared outcomes of patients with hematologic malignancy and IA who were treated with voriconazole using the diagnostic driven DDA (DDA-Vori) that includes galactomannan testing vs. Read More

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December 2018
1 Read

Clinical massage therapy for patients with cancer-related fatigue protocol of a systematic review.

Medicine (Baltimore) 2018 Dec;97(49):e13440

Dongfang Hospital of Beijing University of Chinese Medicine.

Background: Cancer-related fatigue (CRF) is a prevalent and debilitating symptom experienced by cancer survivors, one that severely compromises functional independence and quality of life. Clinical massage therapy (CMT), as an important part of complementary and alternative medicine, is widely employed among massage therapists, physical therapists, nurses, and physicians when managing CRF. Clinical research indicates that CMT produced relief of CRF. Read More

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December 2018

Machine learning methods for automatic pain assessment using facial expression information: Protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13421

Massachusetts General Hospital, Boston, MA.

Introduction: Prediction of pain using machine learning algorithms is an emerging field in both computer science and clinical medicine. Several machine algorithms were developed and validated in recent years. However, the majority of studies in this topic was published on bioinformatics or computer science journals instead of medical journals. Read More

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December 2018
5.723 Impact Factor

Endemicity of the High-Risk Clone Klebsiella pneumoniae ST340 Coproducing QnrB, CTX-M-15, and KPC-2 in a Brazilian Hospital.

Microb Drug Resist 2018 Dec 13. Epub 2018 Dec 13.

3 Centro de Investigação de Microrganismos - Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, Brazil.

The dissemination of multiresistant Klebsiella pneumoniae carbapenemase (KPC)-2-producing Klebsiella pneumoniae isolates belonging to international high-risk clones poses a major health care threat. In this study, 48 nonduplicated, carbapenem-resistant K. pneumoniae isolated from 2011 to 2014 in a tertiary hospital were investigated. Read More

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December 2018

A Rare Instance of Simultaneous Infection with Disseminated Nocardia and Pulmonary Aspergillus in a Patient Receiving Treatment with Ibrutinib for Chronic Lymphocytic Leukemia.

Cureus 2018 Oct 8;10(10):e3427. Epub 2018 Oct 8.

Infectious Disease, Joan C. Edwards School of Medicine - Marshall University, Huntington, USA.

Disseminated Nocardia infections are a rare occurrence that typically occur in immunocompromised hosts. Chronic lymphocytic leukemia (CLL) is a hematologic malignancy which makes patients susceptible to infections through various mechanisms. The treatments for CLL also target immunologic pathways which can contribute to infections. Read More

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October 2018

Author Correction: Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization.

Nat Cell Biol 2018 Dec 12. Epub 2018 Dec 12.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

In the version of this Article originally published, the authors inadvertently included the term 'pericytic mimicry' in relation to ref. 54. This has now been corrected by inserting an additional reference at position 51 and amending the text in the Discussion relating to 'pericytic mimicry', ref. Read More

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December 2018

Afatinib in the Treatment of Advanced Non-Small Cell Lung Cancer with Rare EGFR (in exon 18-T179X) Mutation - a Case Report.

Klin Onkol 2018 ;31(5):380-383

Introduction: Exon 18-T719X EGFR mutation in non-small cell lung cancer is rare, only 1-5% of all EGFR mutations. The efficacy of EGFR tyrosin kinase inhibitors in tumours with uncommon mutations is still unclear and the prediction of response of such tumours to therapy remains unexplored.

Case: A 71-year-old woman with no previous smoking history with disseminated lung adenocarcinoma with exon 18-T719X EGFR mutation was treated with afatinib. Read More

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January 2018

Tumor-to-Tumor Metastasis - a Unique Case of Clear Cell Renal Cell Carcinoma Harboring Metastasis of Adenocarcinoma of Unknown Origin.

Klin Onkol 2018 ;31(5):366-370

Background: The tumor-to-tumor metastasis is exclusively rare finding, in which one malignant neoplasia metastasizes to another tumor of different origin.

Case: The author describes an 68-year-old woman, who was found to have a solitary tumor in the right kidney, as well as multiple tumor nodules in the liver. She underwent a radical nephrectomy. Read More

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January 2018

The Significance of BRAFV600E Mutation in Thyroid Cancer in Terms of Novel Targeted Therapies - Overview of Current Knowledge and Studies.

Klin Onkol 2018 ;31(5):339-344

Background: About 50% of papillary thyroid cancers, the most common type of all thyroid malignancies, harbor the BRAFV600E mutation. The prognostic value of this mutation is still under debate, but according to many studies, the BRAF mutation significantly downregulates genes involved in the iodine metabolism of tumor follicular cells. This mutation can be also found in some dedifferentiated and anaplastic thyroid cancers, which raises the issue of the selective advantage of novel targeted therapies. Read More

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January 2018

Disseminated Adenovirus Infection After Combined Liver-Kidney Transplantation.

Front Cell Infect Microbiol 2018 20;8:408. Epub 2018 Nov 20.

Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC, United States.

Human adenovirus (HAdV) infections are well-described after hematopoietic stem cell transplantation but less well understood in solid organ transplantation (SOT). We describe a case of disseminated HAdV type 21 infection 5 months after combined liver-kidney transplantation, expanding the limited literature describing this infection in the SOT population. Read More

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November 2018

Pulmonary mucormycosis in an adolescent female with type 1 diabetes mellitus.

IDCases 2018 27;14:e00474. Epub 2018 Nov 27.

University of Nevada Las Vegas School of Medicine, Department of Pediatrics, Las Vegas, NV, USA.

Mucormycosis is a relatively rare, life-threatening and opportunistic infection that affects immunocompromised patients. We present the unusual case of pulmonary mucormycosis in a 13-year-old Caucasian female that had recently been diagnosed with type 1 diabetes. Our case serves as an example to healthcare providers treating immunosuppressed patients with pneumonia to have a high clinical suspicion for fungal infections, as delay in diagnosis and treatment can result in disseminated disease and higher patient mortality risk. Read More

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November 2018

Sex and Relationships Education for Individuals with Cystic Fibrosis: A Service-Based Approach.

Sex Disabil 2018 22;36(4):363-376. Epub 2018 Oct 22.

2Bristol Adult CF Centre, Bristol Royal Infirmary, University Hospitals Bristol NHS Foundation Trust, Bristol, BS2 8HW UK.

Increasing life expectancy within cystic fibrosis (CF) raises challenges around previously neglected topics such as sexual and reproductive health (SRH). The study aimed to gather retrospective experiences of service provision around SRH to consider the role of the CF service, age of information provision and unmet needs highlighting possible improvements to provision. A mixed-methods retrospective survey-based design was employed. Read More

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October 2018

Liver scalloping: Pseudomyxoma peritonei liver compression.

J Visc Surg 2018 Dec 3. Epub 2018 Dec 3.

Service de chirurgie digestive, centre hospitalier universtaire Amiens, avenue René-Laennec, 80054 Amiens cedex 01, France; Université Picardie-Jules-Verne, 1, chemin du Thil, 80000 Amiens cedex 01, France; Simplifications des soins patients chirurgicaux complexes, or Simplication of care of complex surgical patients (SSPC), unité de recherché clinique, université Picardie-Jules-Vernes, 80000 Amiens, France. Electronic address:

Pseudomyxoma peritonei is a rare tumor characterized by the presence of mucous disseminated throughout the peritoneal cavity generally arising from the rupture of an appendicular mucocele. Liver scalloping is a highly suggestive image of pseudomyxoma and corresponds to the indentation of the liver compressed by the gelatinous mucin. Read More

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December 2018

Fulminant acute disseminated encephalomyelitis in children.

Brain Dev 2018 Dec 3. Epub 2018 Dec 3.

Department of Pediatrics, St Mary's Hospital, 422 Tsubukuhonmachi, Kurume, Fukuoka 830-8543, Japan; Research Centre for Children and Research Centre for Rett Syndrome, St Mary's Hospital, 422 Tsubukuhonmachi, Kurume, Fukuoka 830-8543, Japan. Electronic address:

Acute disseminated encephalomyelitis (ADEM) is a typically monophasic inflammatory demyelinating disease of the central nervous system with a favorable outcome. However, 2% of ADEM involves acute hemorrhagic leukoencephalitis (AHLE), which is a fulminant and hyperacute variant of ADEM with a poor outcome and high mortality. There are limited case reports of fulminant ADEM including AHLE in children. Read More

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December 2018

Sharing is not always a good thing: Use of a DNA marker to investigate the potential for ward-to-ward dissemination of healthcare-associated pathogens.

Infect Control Hosp Epidemiol 2018 Dec 7:1-3. Epub 2018 Dec 7.

3Geriatric Research,Education and Clinical Center, Cleveland VA Medical Center,Cleveland, Ohio.

A DNA marker inoculated onto portable equipment on a medical ward was disseminated to other wards when equipment was shared and to a physician work room and the hospital cafeteria by personnel. These results demonstrate the plausibility of pathogen transmission in healthcare facilities in the absence of shared ward exposure. Read More

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December 2018

Successful outcome of disseminated mucormycosis in a 3-year-old child suffering from acute leukaemia: the role of isavuconazole? A case report.

BMC Pharmacol Toxicol 2018 Dec 6;19(1):81. Epub 2018 Dec 6.

Laboratoire de Parasitologie Mycologie, CHU Lille, Univ. Lille, INSERM U995 - LIRIC - Lille Inflammation Research International Centre, F-59000, Lille, France.

Background: The use of isavuconazole is approved for the management of invasive aspergillosis and mucormycosis, only in adults, as no paediatric pharmacology studies have been reported to date. Very few paediatric cases have been published concerning the use of isavuconazole. Amphotericin B is the only antifungal agent recommended in paediatric mucormycosis, but adverse effects and especially nephrotoxicity, even with the liposomal formulation, could be problematic. Read More

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December 2018

[Evaluation of the reproductive potential of Encephalitozoon intestinalis in four different cell line].

Mikrobiyol Bul 2018 Oct;52(4):390-400

Erciyes University Faculty of Medicine, Department of Parasitology, Kayseri, Turkey.

Microsporidia are parasites that can cause infections in many vertebrate and invertebrate organisms and produce small spores resistant to environmental conditions. As they are obligate intracellular parasites, axenic cultures cannot be performed. The aim of this study was to investigate the reproductive potential of the parasite in human colon epidermal adenocarcinoma (Caco-2), human monocytic (U937), African green monkey renal epithelial (VERO) and human kidney epithelial (HEK-293) cell lines of tissue and organs where the parasite is located by following the culture of the parasites and the amount of spores for six weeks. Read More

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October 2018

Chitosan-based nanodelivery systems applied to the development of novel triclabendazole formulations.

PLoS One 2018 12;13(12):e0207625. Epub 2018 Dec 12.

Institute of Plant Biology and Biotechnology (IBBP), Westfälische Wilhelms-Universität Münster, Münster, Germany.

Triclabendazole is a poorly-water soluble (0.24 μg/mL) compound classified into the Class II/IV of the Biopharmaceutical Classification System. It is the drug of choice to treat fascioliasis, a neglected parasitic disease worldwide disseminated. Read More

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December 2018
2 Reads

Molecular Epidemiology and Risk Factors of Carbapenemase-Producing Isolates in Portuguese Hospitals: Results From European Survey on Carbapenemase-Producing (EuSCAPE).

Front Microbiol 2018 27;9:2834. Epub 2018 Nov 27.

National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal.

In Portugal, the epidemiological stage for the spread of carbapenemase-producing (CPE) increased from sporadic isolates or single hospital clones (2010-2013), to hospital outbreaks, later. Here we report data from a 6-month study performed under the European Survey on Carbapenemase-Producing (EuSCAPE). During the study period, 67 isolates (61 and 6 ) non-susceptible to carbapenems were identified in participant hospital laboratories. Read More

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November 2018
1 Read

Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis.

Nat Commun 2018 12 11;9(1):5288. Epub 2018 Dec 11.

School of Biosciences, University of Exeter, Geoffrey Pope Building, Exeter, EX4 4QD, UK.

The high global burden of over one million annual lethal fungal infections reflects a lack of protective vaccines, late diagnosis and inadequate chemotherapy. Here, we have generated a unique set of fully human anti-Candida monoclonal antibodies (mAbs) with diagnostic and therapeutic potential by expressing recombinant antibodies from genes cloned from the B cells of patients suffering from candidiasis. Single class switched memory B cells isolated from donors serum-positive for anti-Candida IgG were differentiated in vitro and screened against recombinant Candida albicans Hyr1 cell wall protein and whole fungal cell wall preparations. Read More

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December 2018

-fucosylation of thrombospondin-like repeats is required for processing of microneme protein 2 and for efficient host cell invasion by tachyzoites.

J Biol Chem 2018 Dec 11. Epub 2018 Dec 11.

Molecular and Cell Biology, Boston University, United States.

is an intracellular parasite that causes disseminated infections that can produce neurological damage in fetuses and immunocompromised individuals. Microneme protein 2 (MIC2), a member of the thrombospondin-related anonymous protein (TRAP) family, is a secreted protein important for motility, host cell attachment, invasion, and egress. MIC2 contains six thrombospondin type I repeats (TSRs) that are modified by -mannose and -fucose in spp. Read More

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December 2018

The epithelial-to-mesenchymal transition induced by tumor-associated macrophages confers chemoresistance in peritoneally disseminated pancreatic cancer.

J Exp Clin Cancer Res 2018 Dec 11;37(1):307. Epub 2018 Dec 11.

Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Background: The peritoneum is one of the most frequent metastatic sites in pancreatic cancer patients, and peritoneal dissemination makes this disease refractory due to aggressive progression and chemoresistance. Although the role of the tumor microenvironment in cancer development is recognized, the correlation between the peritoneal environment and refractoriness of peritoneal dissemination remains unclear. The intraperitoneal tumor-microenvironment and its potential role in the progression of peritoneal dissemination and chemo-refractoriness, focusing especially on macrophages, were investigated. Read More

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December 2018

A super-elderly case of abdominal aortic aneurysm associated with chronic disseminated intravascular coagulation.

J Cardiol Cases 2015 Feb 26;11(2):48-51. Epub 2014 Nov 26.

Department of Cardiovascular Medicine, Kobe Rosai Hospital, Kobe, Japan.

Chronic disseminated intravascular coagulation (DIC) is a well-known complication of aortic aneurysm. A 91-year-old Japanese woman was admitted to our hospital because of massive purpura of the lower limbs. The presence of abdominal aortic aneurysm (AAA) had been pointed out from the age of 80 years, and its diameter had gradually increased. Read More

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February 2015

Disseminated lymphoid neoplasia and hepatoblastoma in an Atlantic stingray, Hypanus sabinus (Lesueur 1824).

J Fish Dis 2018 Dec 10. Epub 2018 Dec 10.

Department of Pathology, University of Georgia College of Veterinary Medicine, Athens, Georgia.

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December 2018

Comparison of gabexate mesilate and nafamostat mesilate for disseminated intravascular coagulation associated with hematological malignancies.

Int J Hematol 2018 Dec 8. Epub 2018 Dec 8.

Division of Hematology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

We evaluated clinical outcomes of disseminated intravascular coagulation (DIC) in patients with hematological malignancies treated with synthetic protease inhibitors (SPIs) and compared the effects of gabexate mesilate (FOY) and nafamostat mesilate (FUT). We retrospectively examined 127 patients [acute myeloid leukemia (n = 48), acute lymphoblastic leukemia (n = 25), and non-Hodgkin lymphoma (n = 54)] with DIC, who were diagnosed according to Japanese Ministry of Health, Labour and Welfare criteria and treated with SPIs [FOY (n = 55) and FUT (n = 72)] at our hospital from 2006 to 2015. The DIC resolution rates on days 7 and 14 were 42. Read More

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December 2018
1 Read

[Pathogenesis of multiple myeloma].

Authors:
L Rasche N Weinhold

Internist (Berl) 2018 Dec 10. Epub 2018 Dec 10.

Myeloma Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Background: Multiple myeloma (MM) is a hematologic malignancy characterized by monoclonal plasma cells infiltrating the bone marrow thereby causing anemia and lytic bone lesions. Despite significant improvement in overall survival, most MM patients inevitably, yet unpredictably, develop refractory disease and MM remains largely incurable.

Objective: This article describes the stages of progression and presents current insights into the pathogenesis of MM. Read More

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December 2018

Letter: Steroid Use Associated With Increased Odds of 30-Day Mortality in Surgical Patients With Metastatic Spinal Tumors in the Setting of Disseminated Disease.

Neurosurgery 2018 Dec 11. Epub 2018 Dec 11.

Spine Research Group Montefiore Medical Center/Albert Einstein College of Medicine Bronx, New York.

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December 2018

Klebsiella pneumoniae causing urinary tract infections in companion animals and humans: population structure, antimicrobial resistance and virulence genes.

J Antimicrob Chemother 2018 Dec 10. Epub 2018 Dec 10.

CIISA - Center for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.

Objectives: To characterize the population structure, antimicrobial resistance and virulence genes of Klebsiella spp. isolated from dogs, cats and humans with urinary tract infections (UTIs).

Methods: Klebsiella spp. Read More

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December 2018

Tolerability of long-term fluconazole therapy.

J Antimicrob Chemother 2018 Dec 6. Epub 2018 Dec 6.

Department of Medical Microbiology and Immunology, University of California, Med Science Dr., Davis, CA, USA.

Background: Fluconazole is a commonly prescribed first-generation triazole antifungal. Although the toxicity profile of fluconazole has been evaluated in clinical trials, there are scant data regarding its tolerability with long-term therapy. Treatment guidelines for coccidioidomycosis recommend fluconazole therapy and severe or disseminated infections can require lifelong treatment. Read More

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December 2018

Feasibility and potential efficacy of commercial mHealth/eHealth tools for weight loss in African American breast cancer survivors: pilot randomized controlled trial.

Transl Behav Med 2018 Dec 9. Epub 2018 Dec 9.

Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, USA.

Weight management after breast cancer (BC) treatment in African American (AA) women is crucial to reduce comorbid conditions and health disparities. We examined feasibility and potential efficacy of commercial eHealth/mHealth tools for weight management in AA BC survivors in New Jersey. Participants (N = 35) were randomized to an intervention (SparkPeople) plus activity tracker, Fitbit Charge (n = 18), or wait-list active control group (Fitbit only, n = 17). Read More

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December 2018
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