15,826 results match your criteria Disseminated Intravascular Coagulation


COVID and Coagulation: Bleeding and Thrombotic Manifestations of SARS-CoV2 Infection.

Blood 2020 Jun 3. Epub 2020 Jun 3.

Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States.

Patients with coronavirus disease 2019 (COVID-19) have elevated D-dimer levels. Early reports describe high venous thromboembolism (VTE) and disseminated intravascular coagulation (DIC) rates, but data are limited. This multicenter, retrospective study described the rate and severity of hemostatic and thrombotic complications of 400 hospital-admitted COVID-19 patients (144 critically ill) primarily receiving standard-dose prophylactic anticoagulation. Read More

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http://dx.doi.org/10.1182/blood.2020006520DOI Listing

Re The source of elevated plasma D-dimer levels in COVID-19 infection.

Br J Haematol 2020 Jun 2. Epub 2020 Jun 2.

Department of Medicine and Cardiometabolic Programme-NIHR UCLH/UCL BRC, University College London Hospitals NHS Foundation Trust, Euston Road, London, NW1 2PG, UK.

Markedly elevated levels D-dimers are seen in severe COVID-19 infection and have been related to a poor prognosis . D-dimers are elevated alongside other acute inflammatory plasma markers such as fibrinogen, CRP and serum ferritin . The elevation of plasma D-dimers has been taken to indicate there is a coagulopathy , and the assumption has been made that the increased fibrinolysis is secondary (due to thrombin generation) indeed an indication of disseminated intravascular coagulation (DIC). Read More

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http://dx.doi.org/10.1111/bjh.16907DOI Listing

Infection with SARS-CoV-2 causes abnormal laboratory results of multiple organs in patients.

Aging (Albany NY) 2020 Jun 1;12. Epub 2020 Jun 1.

Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Aim: To evaluate the clinical value of abnormal laboratory results of multiple organs in patients with coronavirus disease 2019 (COVID-2019) and to help clinicians perform correct treatment.

Results: Elevated neutrophil-to-LYM ratio (NLR), D-dimer(D-D), interleukin (IL)-6, IL-10, IL-2, interferon-Y, and age were significantly associated with the severity of illness. However, significant and sustained decreases were observed in the LYM subset (p<0. Read More

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http://dx.doi.org/10.18632/aging.103255DOI Listing

A multicenter prospective validation study on disseminated intravascular coagulation in trauma-induced coagulopathy.

J Thromb Haemost 2020 Jun 1. Epub 2020 Jun 1.

Trauma and Acute Critical Care Center, Medical Hospital, Tokyo Medical and Dental University, Japan.

Background: Trauma-induced coagulopathy (TIC) may progress to disseminated intravascular coagulation (DIC) due to dysregulated inflammatory and coagulofibrinolytic responses to trauma.

Objectives: We explored how DIC and TIC elicit the same coagulofibrinolytic changes which lead to massive transfusion.

Methods: Severely injured trauma patients with an injury severity score≥16 were prospectively included. Read More

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http://dx.doi.org/10.1111/jth.14931DOI Listing

Von Willebrand factor as a thrombotic and inflammatory mediator in critical illness.

Transfusion 2020 Jun 1. Epub 2020 Jun 1.

Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

The endothelial exocytosis of high-molecular-weight multimeric von Willebrand factor (vWF) may occur in critical illness states, including trauma and sepsis, leading to the sustained elevation and altered composition of plasma vWF. These critical illnesses involve the common process of sympathoadrenal activation and loss of the endothelial glycocalyx. As a prothrombotic and proinflammatory molecule that interacts with the endothelium, the alterations exhibited by vWF in critical illness have been implicated in the development and damaging effects of downstream pathologies, such as disseminated intravascular coagulation and systemic inflammatory response syndrome. Read More

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http://dx.doi.org/10.1111/trf.15667DOI Listing

Clinical investigation of the utility of a pair of coagulation-fibrinolysis markers for definite diagnosis of sepsis-induced disseminated intravascular coagulation: A single-center, diagnostic, prospective, observational study.

Thromb Res 2020 May 11;192:116-121. Epub 2020 May 11.

Emergency and Critical Care Center, Tokyo Women's Medical University, Medical Center East, 2-1-10 Nishiogu, Arakawa-ku, Tokyo 116-8567, Japan.

Background: Disseminated intravascular coagulation (DIC) often occurs with sepsis. A scoring system has been used for the diagnosis of DIC, but the system included at least 4 parameters. The purpose of this study was to propose a simple set of DIC criteria with coagulation-fibrinolysis markers (CFMs). Read More

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http://dx.doi.org/10.1016/j.thromres.2020.05.009DOI Listing

Severe HELLP syndrome masquerading as thrombocytopenic thrombotic purpura: a case report.

BMC Nephrol 2020 May 29;21(1):204. Epub 2020 May 29.

Department of Nephrology, CHU Tenon, Assistance Publique-Hopitaux de Paris, Paris, France.

Background: Thrombotic microangiopathies (TMAs) occurring in the postpartum period may be difficult to manage. They present as the combination of mechanical hemolytic anemia and consumption thrombocytopenia due to endothelial dysfunction. The cause of this endothelial aggression can be multiple: thrombocytopenic thrombotic purpura (TTP), HELLP syndrome, antiphospholipid syndrome, atypical hemolytic and uremic syndrome or acute fatty liver of pregnancy. Read More

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http://dx.doi.org/10.1186/s12882-020-01865-yDOI Listing

Coagulopathy of Coronavirus Disease 2019.

Crit Care Med 2020 May 27. Epub 2020 May 27.

Department of Haematology, Manchester Royal Infirmary, Manchester, United Kingdom.

Objectives: Recent studies have reported a high prevalence of thrombotic events in coronavirus disease 2019. However, the significance of thromboembolic complications has not been widely appreciated. The purpose of this review is to provide current knowledge of this serious problem. Read More

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http://dx.doi.org/10.1097/CCM.0000000000004458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255402PMC

Blood Parameters in Treatment with Arsenic Trioxide in Acute Promyelocytic Leukemia: Systematic Review.

Int J Hematol Oncol Stem Cell Res 2020 Apr;14(2):130-139

Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML). APL is famed with some special blood coagulation disorders such as disseminated intravascular coagulation (DIC). The therapeutic methods of APL contain All Trans Retinoic Acid (ATRA), arsenic trioxide (ATO) or/and chemotherapy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231793PMC

Hemostatic laboratory derangements in COVID-19 with a focus on platelet count.

Platelets 2020 May 26:1-6. Epub 2020 May 26.

Department of Biomedical and Molecular Sciences, School of Medicine, Queen's University , Kingston, Canada.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease in 2019 (COVID-19) which rapidly evolved from an outbreak in Wuhan, China into a pandemic that has resulted in over millions of infections and over hundreds of thousands of mortalities worldwide. Various coagulopathies have been reported in association with COVID-19, including disseminated intravascular coagulation (DIC), sepsis-induced coagulopathy (SIC), local microthrombi, venous thromboembolism (VTE), arterial thrombotic complications, and thrombo-inflammation. There is a plethora of publications and conflicting data on hematological and hemostatic derangements in COVID-19 with some data suggesting the link to disease progress, severity and/or mortality. Read More

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http://dx.doi.org/10.1080/09537104.2020.1768523DOI Listing

MICROVASCULAR THROMBOSIS: EXPERIMENTAL AND CLINICAL IMPLICATIONS.

Transl Res 2020 May 23. Epub 2020 May 23.

Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center; Baylor College of Medicine, Houston, TX, USA 77030. Electronic address:

A significant amount of clinical and research interest in thrombosis is focused on large vessels (e.g., stroke, myocardial infarction, deep venous thrombosis, etc. Read More

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http://dx.doi.org/10.1016/j.trsl.2020.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245314PMC

Procoagulation, hypercoagulation and fibrinolytic “shut down” detected with ClotPro® viscoelastic tests in COVID-19 patients.

Orv Hetil 2020 05;161(22):899-907

Általános Orvostudományi Kar, Transzplantációs és Sebészeti Klinika,Semmelweis Egyetem Budapest, Baross u. 23-25., 1083.

Introduction: International data indicate that arterial, venous and microvascular thrombosis or disseminated intravascular coagulation occur in more than 30% of hospitalized patients with COVID-19. This condition is characterized by high levels of D-dimer and fibrinogen, prolonged prothrombin time and activated partial thromboplastin time.

Method: Blood samples from three COVID-19 patients treated in a Hungarian intensive care unit were collected and analyzed with ClotPro® tests. Read More

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http://dx.doi.org/10.1556/650.2020.31870DOI Listing

Protease Inhibitors: Candidate Drugs to Inhibit Severe Acute Respiratory Syndrome Coronavirus 2 Replication.

Tohoku J Exp Med 2020 05;251(1):27-30

Laboratory of Health and Sports Science, Division of Biomedical Engineering for Health and Welfare, Tohoku University Graduate School of Biomedical Engineering.

The number of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly increased, although the WHO declared a pandemic. However, drugs that function against SARS-CoV-2 have not been established. SARS-CoV-2 has been suggested to bind angiotensin-converting enzyme 2, the receptor of the SARS coronavirus. Read More

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http://dx.doi.org/10.1620/tjem.251.27DOI Listing

Successful surgical drainage with intraoperative ultrasonography for amebic liver abscess refractory to metronidazole and percutaneous drainage: a case report.

BMC Surg 2020 May 24;20(1):112. Epub 2020 May 24.

Department of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

Background: Metronidazole (MNZ) has been clearly established as a medication for amebic liver abscess. In uncomplicated cases, surgical drainage should be avoided. We report a case of amebic liver abscess refractory to MNZ that was successfully treated using preoperative computed tomography (CT) and percutaneous and surgical drainage with intraoperative ultrasonography (IOUS). Read More

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http://dx.doi.org/10.1186/s12893-020-00776-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247227PMC

[Clinical and coagulation characteristics in 7 patients with critical COVID-2019 pneumonia and acro-ischemia].

Zhonghua Xue Ye Xue Za Zhi 2020 Apr;41(4):302-307

Department of Infection Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

To investigate the clinical and coagulation characteristics in patients with critical Coronavirus disease 2019 (COVID-19) and acro-ischemia. The retrospective study included 7 critical COVID-19 patients with acro-ischemia in an intensive care unit (ICU) in Wuhan, from Feb 4 to Feb 15, 2020. The clinical and laboratory data before and during the ICU stay were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.008DOI Listing

Hemorrhage in acute promyelocytic leukemia: Can it be predicted and prevented?

Leuk Res 2020 Jul 11;94:106356. Epub 2020 May 11.

Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Hemorrhagic death is the leading cause of treatment failure in acute promyelocytic leukemia (APL). Our ability to identify patients at greatest risk of hemorrhage, and to actively prevent hemorrhage, remains limited. Nevertheless, some data is available to guide contemporary clinical practice and future investigation. Read More

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http://dx.doi.org/10.1016/j.leukres.2020.106356DOI Listing

Drug-induced disseminated intravascular coagulation: a pharmacovigilance study on World Health Organization's database.

J Thromb Thrombolysis 2020 May 22. Epub 2020 May 22.

Unit of Pharmacology, Department of Medical and Surgical Sciences, University of Bologna, via Irnerio 48, 40126, Bologna, Italy.

Background: Disseminated intravascular coagulation (DIC) occurs in several clinical conditions, including drug therapy. We aim to investigate the association between the administration of several drug classes and the onset of DIC by using the reports of Adverse Drug Reactions (ADR) collected in Vigibase, the World Health Organization (WHO) database of ADR.

Methods: We collected reports of drug-related DIC from 1968 to September 2015, classified in Vigibase according to the MedDRA (Medical Dictionary for Regulatory Activities) term "Disseminated intravascular coagulation". Read More

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http://dx.doi.org/10.1007/s11239-020-02147-yDOI Listing

Rifampicin-induced disseminated intravascular coagulation: An antibody-mediated side effect.

Pulmonology 2020 May 18. Epub 2020 May 18.

Internal Medicine Department, Hospital do Divino Espírito Santo, Ponta Delgada, Portugal.

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http://dx.doi.org/10.1016/j.pulmoe.2020.04.006DOI Listing

Plasmapheresis in Sepsis-induced Thrombotic Microangiopathy: A Case Series.

Indian J Crit Care Med 2020 Mar;24(3):195-199

Department of Nephrology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India.

Introduction: Cytokines and granulocyte elastase produced in sepsis cleave a disintegrin and metalloprotease with thrombospondin type I motif 13 (ADAMTS13) and deplete its levels. By this mechanism, sepsis results in microangiopathic hemolytic anemia (MAHA) with thrombocytopenia. Hence, the hypothesis is that plasmapheresis may help in sepsis-induced thrombotic microangiopathy (sTMA), by removing the factors responsible for low levels of ADAMTS13. Read More

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http://dx.doi.org/10.5005/jp-journals-10071-23374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225771PMC

Rapidly Resolving and Recurrent Contralateral Subdural Hematoma From Disseminated Intravascular Coagulation.

J Stroke Cerebrovasc Dis 2020 May 18:104872. Epub 2020 May 18.

Department of Neurology, Mayo Clinic, Jacksonville, Florida, United States; Department of Critical Care Medicine, Mayo Clinic, Jacksonville, Florida, United States; Department of Neurologic Surgery, Mayo Clinic, Jacksonville, Florida, United States. Electronic address:

Background: Acute, recurrent subdural hematoma (SDH) is a rare entity in the absence of trauma. Atraumatic SDH may be due to vascular disorders, coagulopathies, or intracranial hypotension. It is a rare complication of disseminated intravascular coagulation (DIC), with no prior reports in patients with intracranial metastatic colon cancer (MCC). Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2020.104872DOI Listing

Thromboelastography as a Tool for Monitoring Blood Coagulation Dysfunction after Adequate Fluid Resuscitation can Predict Poor Outcomes in Patients with Septic Shock.

J Chin Med Assoc 2020 May 15. Epub 2020 May 15.

Department of Emergency Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: Coagulation abnormalities are universal in patients with septic shock and likely play a key role in multiple organ dysfunction syndrome. Early diagnosis and management of sepsis-induced coagulopathy can influence the outcome. Thromboelastography (TEG) can effectively distinguish hypercoagulability and hypocoagulability in patients with septic shock. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000345DOI Listing

The SARS-CoV-2 receptor, ACE-2, is expressed on many different cell types: implications for ACE-inhibitor- and angiotensin II receptor blocker-based cardiovascular therapies.

Intern Emerg Med 2020 May 19. Epub 2020 May 19.

Cardiology Unit, San Giuseppe Hospital-MultiMedica, Milan, Italy.

SARS-CoV-2 is characterized by a spike protein allowing viral binding to the angiotensin-converting enzyme (ACE)-2, which acts as a viral receptor and is expressed on the surface of several pulmonary and extra-pulmonary cell types, including cardiac, renal, intestinal and endothelial cells. There is evidence that also endothelial cells are infected by SARS-COV-2, with subsequent occurrence of systemic vasculitis, thromboembolism and disseminated intravascular coagulation. Those effects, together with the "cytokine storm" are involved in a worse prognosis. Read More

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http://dx.doi.org/10.1007/s11739-020-02364-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236433PMC

Could severe COVID-19 be considered a complementopathy?

Lupus Sci Med 2020 05;7(1)

Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet Department of Medicine Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1136/lupus-2020-000415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246101PMC

COVID-19 and coagulative axis: review of emerging aspects in a novel disease.

Monaldi Arch Chest Dis 2020 May 19;90(2). Epub 2020 May 19.

Department of Medicine and Health Sciences "V. Tiberio", University of Molise, Campobasso.

Latest evidences from literature suggest that SARS-CoV-2 disease 2019 (COVID-19) is commonly complicated with coagulopathy and that disseminated intravascular coagulation is present in the majority of deceased patients. Particularly, conventional coagulation parameters appear to be significantly altered in patients with poor prognosis. A wide-ranging cross- talk between coagulative haemostasis and inflammation, as well as the activation of coagulation cascade during viral infections, are well established. Read More

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http://dx.doi.org/10.4081/monaldi.2020.1300DOI Listing

Efficacy of recombinant thrombomodulin for poor prognostic cases of acute exacerbation in idiopathic interstitial pneumonia: secondary analysis of the SETUP trial.

BMJ Open Respir Res 2020 May;7(1)

Clinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Sakai City, Osaka, Japan

Background: Acute exacerbation (AE) in idiopathic pulmonary fibrosis and other idiopathic interstitial pneumonias (IIPs) are poor prognostic events although they are usually treated with conventional therapy with corticosteroids and immunosuppressants. Previously, we demonstrated the safety and efficacy of recombinant human soluble thrombomodulin (rhTM) for AE-IIP in the SETUP trial. Here, we aimed to clarify the efficacy of rhTM for poor-prognosis cases of AE-IIP. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239513PMC

Hypofibrinogenemia and disseminated intravascular coagulation rarely complicate treatment-naïve acute lymphoblastic leukemia.

Leuk Lymphoma 2020 May 18:1-5. Epub 2020 May 18.

Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1080/10428194.2020.1765236DOI Listing

COVID-19-associated immune thrombocytopenia.

Br J Haematol 2020 May 18. Epub 2020 May 18.

Department of Hematology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.

Thrombocytopenia is a risk factor for increased morbidity and mortality in patients with the new severe acute respiratory syndrome corona virus, SARS-CoV-2 infection (COVID-19 infection). Thrombocytopenia in COVID-19 patients may be caused by disseminated intravascular coagulation (DIC), sepsis or drug-induced. Recently a single case report suggested immune thrombocytopenia (ITP) may be associated with COVID-19 infection. Read More

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http://dx.doi.org/10.1111/bjh.16850DOI Listing

Disseminated intravascular coagulation in advanced lung adenocarcinoma during first-line pembrolizumab.

Immunotherapy 2020 May 18. Epub 2020 May 18.

Department of Oncology, San Gerardo Hospital, Asst-Monza, via Pergolesi 33 Monza, Italy.

Every year 1.6 million people worldwide die from lung cancer, making it one of the most frequent and deadly tumors. Pembrolizumab is a humanized monoclonal antibody against PD-1 that has antitumor activity in advanced non-small-cell lung cancer, with increased activity in tumors that express programmed death ligand 1. Read More

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http://dx.doi.org/10.2217/imt-2020-0018DOI Listing

PECAM-1 protects against DIC by dampening inflammatory responses via inhibiting macrophage pyroptosis and restoring vascular barrier integrity.

Transl Res 2020 May 14. Epub 2020 May 14.

Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Collaborative Innovation Center of Hematology, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.

Disseminated intravascular coagulation (DIC) is a frequent complication of sepsis that affects patient outcomes due to accompanying thrombo-inflammation and microvascular permeability changes. Platelet endothelial cell adhesion molecule-1 (PECAM-1), a cellular adhesion and signaling receptor that is expressed on both hematopoietic and endothelial cells, plays an important anti-inflammatory role in acute and chronic inflammatory disease models. Little is known, however, about role and mechanism of PECAM-1 in septic DIC. Read More

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http://dx.doi.org/10.1016/j.trsl.2020.04.005DOI Listing

Predictors of fatal outcome after severe necrotizing fasciitis: Retrospective analysis in a tertiary hospital for 20 years.

J Orthop Sci 2020 May 12. Epub 2020 May 12.

Department of Orthopaedic Surgery, School of Medicine, Jichi Medical University, Shimotsuke, Japan.

Background: Prognostic factors for fatal outcomes of patients with necrotizing fasciitis remain unclear.

Methods: We retrospectively analyzed data of patients with necrotizing fasciitis from January 1998 to July 2019 using our hospital's medical database. Clinical characteristics of patients who died during hospitalization or had been discharged were evaluated. Read More

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http://dx.doi.org/10.1016/j.jos.2020.04.007DOI Listing

COVID-19: progression of disease and intravascular coagulation - present status and future perspectives.

Clin Chem Lab Med 2020 May 14. Epub 2020 May 14.

Department of Haematology, Sydney Centres for Thrombosis and Haemostasis, Institute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead Hospital, Westmead, New South Wales, Australia.

The timely and accurate diagnosis of infection with severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19), remains the cornerstone of efforts to provide appropriated treatment for patients, to limit further spread of the virus and ultimately to eliminate the virus from the human society. We focus this article on (a) developments for improvement of diagnosis of specific SARS-CoV-2 virus, (b) laboratory changes in the immunologic and coagulation system, (c) therapeutic options for anticoagulant treatment of seriously affected patients and (d) on the perspectives through improvement of diagnostic and therapeutic medical procedures. Read More

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http://dx.doi.org/10.1515/cclm-2020-0502DOI Listing

Organ function support in patients with coronavirus disease 2019: Tongji experience.

Front Med 2020 Apr 14;14(2):232-248. Epub 2020 May 14.

Department of Emergency and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Coronavirus disease 2019 (COVID-19) is a highly contagious disease and a serious threat to human health. COVID-19 can cause multiple organ dysfunction, such as respiratory and circulatory failure, liver and kidney injury, disseminated intravascular coagulation, and thromboembolism, and even death. The World Health Organization reports that the mortality rate of severe-type COVID-19 is over 50%. Read More

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http://dx.doi.org/10.1007/s11684-020-0774-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220847PMC

Beneficial effect modification on survival outcome of sepsis between ART-123 and polymyxin B‑immobilised haemoperfusion: a nationwide Japanese registry study.

Ann Intensive Care 2020 May 13;10(1):57. Epub 2020 May 13.

Department of Emergency and Critical Care Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

Background: Although recently published randomised controlled trials did not confirm significant positive effect of ART-123 or polymyxin B‑immobilised haemoperfusion (PMX-HP) on survival outcome, previous studies using a dataset of 3195 patients with sepsis registered at 42 intensive care units throughout Japan revealed significantly reduced mortality following these treatments. A study has suggested the efficacy of combination therapy with ART-123 and PMX-HP; however, it did not evaluate the effect modification between them. We hypothesised that coadministration of ART-123 and PMX-HP has a significant positive effect modification on survival outcome. Read More

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http://dx.doi.org/10.1186/s13613-020-00674-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221014PMC

A severe course of serogroup W meningococcemia in a patient with infantile nephropathic cystinosis.

Hum Vaccin Immunother 2020 May 13:1-2. Epub 2020 May 13.

Faculty of Medicine, Department of Pediatric Intensive Care, Eskisehir Osmangazi University, Eskisehir, Turkey.

We present a 9-month old boy with cystinosis admitted to our hospital with the complaints of vomiting, diarrhea and seizure. While he was hospitalized in a pediatric intensive care unit due to worsening of his signs related to cystinosis, within hours, he suffered complications of septic shock, acute renal failure, and disseminated intravascular coagulation, due to invasive serogroup W disease. Our patient is the first reported case of invasive meningococcal disease with cystinosis. Read More

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http://dx.doi.org/10.1080/21645515.2020.1742508DOI Listing

Deep Vein Thrombosis and Pulmonary Embolism: Two Complications of COVID-19 Pneumonia?

Eur J Case Rep Intern Med 2020 8;7(5):001646. Epub 2020 Apr 8.

Emergency Department, Guglielmo da Saliceto Hospital, Piacenza, Italy.

Coronavirus disease 19 (COVID-19) is a worldwide infection which was recently declared a global health emergency by the WHO Emergency Committee. The most common symptoms are fever and cough, which can progress to pneumonia, acute respiratory distress syndrome (ARDS) and/or end-organ failure. Risk factors associated with ARDS and death are older age, comorbidities (e. Read More

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http://dx.doi.org/10.12890/2020_001646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213837PMC

COVID-19 in Children, Pregnancy and Neonates: A Review of Epidemiologic and Clinical Features.

Pediatr Infect Dis J 2020 06;39(6):469-477

Department of Paediatrics, The University of Melbourne, Parkville, Australia.

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has spread rapidly across the globe. In contrast to initial reports, recent studies suggest that children are just as likely as adults to become infected with the virus but have fewer symptoms and less severe disease. In this review, we summarize the epidemiologic and clinical features of children infected with SARS-CoV-2 reported in pediatric case series to date. Read More

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http://dx.doi.org/10.1097/INF.0000000000002700DOI Listing

Standard and derived rotational thromboelastometry parameters for prediction of disseminated intravascular coagulation in septic patients.

Blood Coagul Fibrinolysis 2020 May 7. Epub 2020 May 7.

Department of Anesthesia and Intensive Care III, Fundeni Clinical Institute, Bucharest, Romania.

: Waiting for lab tests results for the calculation of disseminated intravascular coagulation (DIC) scores leads to unwanted delays in diagnosis. The use of rotational thromboelastometry (ROTEM) for this purpose would allow for a more rapid DIC diagnosis at the bedside. The aim of this study was to assess the ability of standard ROTEM parameters and calculated parameters from the ROTEM velocity curve to predict DIC. Read More

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http://dx.doi.org/10.1097/MBC.0000000000000919DOI Listing

Chondromesenchymal hamartomas in a 24-year-old male mimicking a posterior mediastinal tumor and a 5-month-old boy with postoperative disseminated intravascular coagulation: two case reports.

Diagn Pathol 2020 May 12;15(1):53. Epub 2020 May 12.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.

Background: Chondromesenchymal hamartoma of the chest wall is a rare, benign disease that usually presents at birth or in early infancy. It typically involves one or more ribs, forming a unilateral or bilateral extrapleural mass. Patients may be asymptomatic or complain of mild respiratory distress depending on tumor size and location. Read More

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http://dx.doi.org/10.1186/s13000-020-00940-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218570PMC
May 2020
2.411 Impact Factor

Coagulopathy in the nephrotic syndrome.

Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):545-548

Department of Nephrology, Rajagiri Hospital, Aluva, Cochin, Kerala, India.

Coagulopathy in the nephrotic syndrome (NS) is very rare. Simultaneous prolongation of both prothrombin time and activated partial thromboplastin time suggests common coagulation pathway abnormality such as liver dysfunction, Vitamin K deficiency, disseminated intravascular coagulation, or primary fibrinolysis. This results in difficulty in proceeding with renal biopsy and tissue diagnosis. Read More

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http://dx.doi.org/10.4103/1319-2442.284035DOI Listing

Clotting Factors in COVID-19: Epidemiological Association and Prognostic Values in Different Clinical Presentations in an Italian Cohort.

J Clin Med 2020 May 7;9(5). Epub 2020 May 7.

Department of Medical Sciences, Humanitas University, 20090 Milan, Italy.

Introduction: A novel highly pathogenic human coronavirus able to induce severe acute respiratory syndrome (SARS) has been recently recognized as the cause of the coronavirus disease 2019 (COVID-19) outbreak, which has spread rapidly from China to other countries. Little is known about laboratory prognostic markers in COVID-19 patients. The aim of our study was to describe the basic clotting parameters in COVID-19 patients and their prognostic role in different clinical forms of the disease. Read More

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http://dx.doi.org/10.3390/jcm9051371DOI Listing

Argatroban Treatment and Decreased Fibrinogen in a Septic Patient.

Cureus 2020 Apr 7;12(4):e7573. Epub 2020 Apr 7.

Internal Medicine/Pulmonology, Joan C. Edwards School of Medicine, Marshall University, Huntington, USA.

Disseminated intravascular coagulation (DIC) is a consumptive coagulopathy associated with multiple conditions. Diagnosis is based upon clinical and laboratory findings with assessment of fibrinogen, platelets, D-dimer, prothrombin time/international normalized ratio and activated partial thromboplastin time. Herein, we report a case of a 39-year-old female patient diagnosed with endocarditis complicated by pulmonary septic emboli. Read More

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http://dx.doi.org/10.7759/cureus.7573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205380PMC

Successful Treatment with Edoxaban for Disseminated Intravascular Coagulation in a Case of Aortic Dissection Complicated with Immune Thrombocytopenic Purpura.

Intern Med 2020 May 8. Epub 2020 May 8.

Department of Hematology, Niigata Prefectural Shibata Hospital, Japan.

A 70-year-old woman was hospitalized for exacerbation of chronic idiopathic thrombocytopenic purpura (ITP) and disseminated intravascular coagulation (DIC) from old aortic dissection. Initially, we increased the dose of prednisolone for ITP. However, her bleeding tendency caused by DIC worsened despite the rapid recovery of her platelet count, and the required amount of fresh-frozen plasma for transfusion increased. Read More

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http://dx.doi.org/10.2169/internalmedicine.4255-19DOI Listing

Predictors of in-hospital mortality in patients with left ventricular assist device.

Ir J Med Sci 2020 May 9. Epub 2020 May 9.

Department of Cardiology, Calhoun Cardiology Center University of Connecticut, Farmington, CT, USA.

Background: A left ventricular assist device (LVAD) is used to support patients with end-stage heart failure.

Aims: To examine the role of comorbidities and complications in predicting in-hospital mortality since the introduction of continuous flow (CF)-LVAD.

Methods: The Nationwide Inpatient Sample was queried from 2010 to 2014 using International Classification of Disease-9 code for LVAD among patients 18 years or older. Read More

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http://dx.doi.org/10.1007/s11845-020-02246-yDOI Listing
May 2020
0.573 Impact Factor

[Clinical predictive value of short-term dynamic changes in platelet counts for prognosis of sepsis patients in intensive care unit: a retrospective cohort study in adults].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2020 Mar;32(3):301-306

Department of Critical Care Medicine, Shanghai Jiao Tong University Affiliated General Hospital (Shanghai General Hospital), Shanghai 201620, China.

Objective: To explore clinical predictive value of short-term dynamic changes in platelet counts (PLT) for prognosis of sepsis patients in intensive care unit (ICU).

Methods: A retrospective cohort study was conducted. The patients aging 18 to 80 years old who were diagnosed by Sepsis-3 admitted to ICU of South Branch of Shanghai General Hospital from November 2015 to October 2018 were enrolled. Read More

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http://dx.doi.org/10.3760/cma.j.cn121430-20190909-00069DOI Listing

Hematological toxicities in immune checkpoint inhibitors: a pharmacovigilance study from 2014 to 2019.

Hematol Oncol 2020 May 8. Epub 2020 May 8.

Department of Health Statistics, Second Military Medical University, Shanghai, China.

Immune checkpoint inhibitors (ICIs) have shown remarkable clinical effects in many cancer types. However, ICIs could also induce severe organ system toxicities, including those of the hematological system. The present study aimed to extensively characterize the hematological toxicities of ICIs immunotherapy. Read More

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http://dx.doi.org/10.1002/hon.2743DOI Listing

Response to "Lupus anticoagulant is frequent in patients with Covid-19".

Authors:
Ning Tang

J Thromb Haemost 2020 May 7. Epub 2020 May 7.

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

We appreciate the opportunity to respond to the letter from Dr. Inès Harzallah, et al. Antiphospholipid antibody assays including lupus anticoagulant (LAC), anticardiolipin and anti-β2-glycoprotein I have also been performed in dozens of our patients, however, very few of them got positive results, we don't think that antiphospholipid antibody exists universally in COVID-19 patients. Read More

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http://dx.doi.org/10.1111/jth.14890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267361PMC

[Various functions of plasma histidine-rich glycoprotein and its clinical application as the biomarker and therapeutic drug for sepsis].

Nihon Yakurigaku Zasshi 2020 ;155(3):155-158

Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences.

Histidine-rich glycoprotein (HRG) is a 75 kDa plasma glycoprotein synthesized in liver mainly, which exists at approximately 60-100 μg/ml in human plasma. HRG is known to bind to several ligands and cells, leading to exert coagulation, fibrinolysis, immune and inflammation regulatory activity in septic condition. Thus, decreased plasma HRG level induces the dysregulations of coagulation, fibrinolysis and immune system, resulting in disseminated intravascular coagulation and multiple organ failure. Read More

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http://dx.doi.org/10.1254/fpj.19150DOI Listing
January 2020

Early Diagnosis of the Cardiopulmonary Collapse Type of Amniotic Fluid Embolism with Obstetrical Disseminated Intravascular Coagulation during Elective Cesarean Section : A Case Report.

J Med Invest 2020 ;67(1.2):207-210

Department of Anesthesiology, Tokushima University Graduate School, Tokushima, Japan.

Two types of amniotic fluid embolism (AFE) have been described : cardiopulmonary collapse type and disseminated intravascular coagulation (DIC) type, with the latter proposed as uterine type. This report describes a healthy 28-year-old woman who developed AFE during a cesarean section. Because of a previous cesarean section, the patient underwent an elective cesarean section, under combined spinal-epidural anesthesia, at 38 weeks of pregnancy. Read More

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http://dx.doi.org/10.2152/jmi.67.207DOI Listing
January 2020