9,181 results match your criteria Disseminate and Recurrent Infundibular Folliculitis

COVID-19 Information Dissemination: A Retrospective Analysis of the WeChat Communication Index.

J Med Internet Res 2021 Jun 10. Epub 2021 Jun 10.

School of Management, Weifang Medical University, Weifang, Shandong, CN.

Background: The COVID-19 outbreak has tremendously impacted the world. The number of the confirmed cases has continued to increase, causing damage to the society and the economy worldwide. The public pays close attention to the information on the pandemic and learns about the disease through various media outlets. Read More

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Automation of Article Selection Process in Systematic Reviews Through Artificial Neural Network Modeling and Machine Learning: Protocol for an Article Selection Model.

JMIR Res Protoc 2021 Jun 15;10(6):e26448. Epub 2021 Jun 15.

Department of Science and Technology, Universidade Federal de São Paulo, São Paulo, Brazil.

Background: A systematic review can be defined as a summary of the evidence found in the literature via a systematic search in the available scientific databases. One of the steps involved is article selection, which is typically a laborious task. Machine learning and artificial intelligence can be important tools in automating this step, thus aiding researchers. Read More

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Primary care professionals' attitudes towards digital health interventions for common mental disorders: study protocol for a mixed methods systematic review.

BMJ Open 2021 06 14;11(6):e045657. Epub 2021 Jun 14.

Institute of General Practice, University of Frankfurt, Frankfurt am Main, Germany

Introduction: Mental disorders such as depression are common, and an estimated 264 million people are affected by them throughout the world. In recent years, studies on digital health interventions to treat mental disorders have shown evidence of their efficacy, and interest in using them has increased as a result. In the primary care setting, depression and anxiety are the two most frequently diagnosed and treated mental disorders. Read More

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Maintenance of the human memory T cell repertoire by subset and tissue site.

Genome Med 2021 Jun 14;13(1):100. Epub 2021 Jun 14.

Department of Microbiology and Immunology, Columbia University, New York, NY, USA.

Background: Immune-mediated protection is mediated by T cells expressing pathogen-specific T cell antigen receptors (TCR) that are maintained at diverse sites of infection as tissue-resident memory T cells (TRM) or that disseminate as circulating effector-memory (TEM), central memory (TCM), or terminal effector (TEMRA) subsets in blood and tissues. The relationship between circulating and tissue resident T cell subsets in humans remains elusive, and is important for promoting site-specific protective immunity.

Methods: We analyzed the TCR repertoire of the major memory CD4 and CD8T cell subsets (TEM, TCM, TEMRA, and TRM) isolated from blood and/or lymphoid organs (spleen, lymph nodes, bone marrow) and lungs of nine organ donors, and blood of three living individuals spanning five decades of life. Read More

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Engineering a 3D collective cancer invasion model with control over collagen fiber alignment.

Biomaterials 2021 Jun 4;275:120922. Epub 2021 Jun 4.

Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address:

Prior to cancer cell invasion, the structure of the extracellular matrix (ECM) surrounding the tumor is remodeled, such that circumferentially oriented matrix fibers become radially aligned. This predisposed radially aligned matrix structure serves as a critical regulator of cancer invasion. However, a biomimetic 3D model recapitulating a tumor's behavioral response to these ECM structures is not yet available. Read More

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Improving the Delivery of High-Quality Cancer Care in Medically Underserved Communities: A Formative Evaluation Method.

Qual Manag Health Care 2021 Jun 14. Epub 2021 Jun 14.

Harvard Medical School, Dana-Farber Cancer Institute, Boston, Massachusetts (Dr Jacobson); Department of Surgery, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine, Dartmouth, New Hampshire (Dr Wong); Clinical Affairs & Guidelines, Infectious Diseases Society of America, Arlington, Virginia (Dr Wollins); and International Quality Programs and Performance Improvement (Ms Gilmore) and Performance Improvement Program and Grants, Clinical Affairs (Mr Cunningham), American Society of Clinical Oncology, Alexandria, Virginia. Dr Quinn is an independent consultant.

Background And Objectives: In 2015, the American Society of Clinical Oncology launched a new program: Improving Quality of Care in Underserved Communities with the overarching aim of serving patients with cancer who have traditionally had difficulty accessing the care they need. Cancer care requires intense coordination of complex services to provide safe, effective, timely, and equitable care. If chemotherapy and/or radiation is needed, patients must navigate a complex system of care many times, a formidable challenge for many disadvantaged patients. Read More

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One-Pot Synthesis of Carboxymethyl-Dextran Coated Iron Oxide Nanoparticles (CION) for Preclinical fMRI and MRA Applications.

Neuroimage 2021 Jun 8:118213. Epub 2021 Jun 8.

Center for Animal MRI, University of North Carolina, Chapel Hill, NC, USA; Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, USA; Department of Neurology, University of North Carolina, Chapel Hill, NC, USA. Electronic address:

Superparamagnetic iron-oxide nanoparticles are robust contrast agents for magnetic resonance imaging (MRI) and has shown promise for sensitive structural and functional mapping of the cerebral blood volume (CBV) when administered intravenously. To date, many CBV-MRI studies are conducted with Feraheme, manufactured for the treatment of iron-deficiency. Unfortunately, Feraheme is currently not available outside the United States due to commercial and regulatory constraints, making the CBV-MRI method either inaccessible or very costly to achieve. Read More

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Shaofu Zhuyu decoction for primary dysmenorrhea: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e26226

College of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.

Background: Primary dysmenorrhea (PD), one of the common gynecological diseases, is more common in adolescent women. According to epidemiological investigation, the incidence of PD accounts for about 60% of all patients with dysmenorrhea, and its symptoms seriously affect the normal working life of women, so it is important to find a more safe and effective treatment. In recent years, traditional Chinese medicine has made a lot of achievements in the treatment of female PD, among which a number of clinical studies have shown that Shaofu Zhuyu decoction (SFZY) can significantly improve the symptoms of dysmenorrhea and improve the therapeutic effect. Read More

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A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis.

Elife 2021 Jun 11;10. Epub 2021 Jun 11.

The School of Medicine, Nankai University, Tianjin, China.

Transcoelomic spread of cancer cells across the peritoneal cavity occurs in most initially diagnosed ovarian cancer (OC) patients and accounts for most cancer-related death. However, how OC cells interact with peritoneal stromal cells to evade the immune surveillance remains largely unexplored. Here, through an in vivo genome-wide CRISPR/Cas9 screen, we identified IL20RA, which decreased dramatically in OC patients during peritoneal metastasis, as a key factor preventing the transcoelomic metastasis of OC. Read More

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Tough Choices: Exploring Medication Decision-Making During Pregnancy and Lactation Among Women With Inflammatory Arthritis.

ACR Open Rheumatol 2021 Jun 11. Epub 2021 Jun 11.

Duke University Medical Center, Durham, North Carolina.

Objective: This study explored how women's beliefs about drug safety and interactions with their health care providers influenced their decisions to continue arthritis medications during pregnancy and lactation.

Methods: We collaborated with ArthritisPower, a patient-powered research network, and CreakyJoints, its partner online community, to develop and disseminate a survey among members with inflammatory arthritis who had at least one pregnancy after diagnosis. Participants' free-text responses were evaluated by using thematic analysis. Read More

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Assessing knowledge, attitudes, and practices towards causal directed acyclic graphs: a qualitative research project.

Eur J Epidemiol 2021 Jun 10. Epub 2021 Jun 10.

Department of Epidemiology, Boston University School of Public Health, Boston, MA, 02118, USA.

Causal graphs provide a key tool for optimizing the validity of causal effect estimates. Although a large literature exists on the mathematical theory underlying the use of causal graphs, less literature exists to aid applied researchers in understanding how best to develop and use causal graphs in their research projects. We sought to understand why researchers do or do not regularly use DAGs by surveying practicing epidemiologists and medical researchers on their knowledge, level of interest, attitudes, and practices towards the use of causal graphs in applied epidemiology and health research. Read More

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Using the Socio-Ecological Model to Frame the Influence of Stakeholders on Cocoa Farmers' Pesticide Safety in Nigeria: Findings from a Qualitative Study.

Risk Manag Healthc Policy 2021 3;14:2357-2368. Epub 2021 Jun 3.

College of Public Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.

Purpose: The aim of this study was to explore the roles of stakeholders on cocoa farmers' safe pesticide use in Nigeria using the socio-ecological model as the theoretical framework.

Methods: This was a cross-sectional qualitative study where participants were purposefully selected based on some criteria. Then, they were interviewed in-depth using a semi-structured interview approach. Read More

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Protocol for a realist synthesis of health systems responsiveness in low-income and middle-income countries.

BMJ Open 2021 06 10;11(6):e046992. Epub 2021 Jun 10.

Nossal Institute for Global Health, University of Melbourne Queen's College, Parkville, Victoria, Australia.

Introduction: Health systems responsiveness is a key objective of any health system, yet it is the least studied of all objectives particularly in low-income and middle-income countries. Research on health systems responsiveness highlights its multiple elements, for example, dignity and confidentiality. Little is known, however, about underlying theories of health systems responsiveness, and the mechanisms through which responsiveness works. Read More

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The microbial and host factors that govern Candida gastrointestinal colonization and dissemination.

Curr Opin Microbiol 2021 Jun 7;63:29-35. Epub 2021 Jun 7.

Department of Pediatrics, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pediatrics, Division of Hematology/Oncology, University of Texas, Southwestern Medical Center, Dallas, TX, USA; Department of Microbiology, University of Texas, Southwestern Medical Center, Dallas, TX, USA; Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

Candida species are among the most prevalent and abundant members of the gut mycobiota, with Candida albicans (CA) being the most prominent member. CA colonizes numerous mucosal surfaces, most notably the gastrointestinal (GI) and genitourinary tracts. In a healthy host, CA is a pathobiont that exists as a commensal but can become pathogenic if the host's immune system becomes suppressed. Read More

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Surveilling and Tracking COVID-19 Patients Using a Portable Quantum Dot Smartphone Device.

Nano Lett 2021 Jun 10. Epub 2021 Jun 10.

Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.

The ability to rapidly diagnose, track, and disseminate information for SARS-CoV-2 is critical to minimize its spread. Here, we engineered a portable smartphone-based quantum barcode serological assay device for real-time surveillance of patients infected with SARS-CoV-2. Our device achieved a clinical sensitivity of 90% and specificity of 100% for SARS-CoV-2, as compared to 34% and 100%, respectively, for lateral flow assays in a head-to-head comparison. Read More

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Skincare in Social Media: Analyzing Prominent Themes in Online Dermatologic Discussions.

Aakash Reddy

Cureus 2021 May 7;13(5):e14890. Epub 2021 May 7.

College of Natural Sciences, University of Texas at Austin, Austin, USA.

Introduction: As the size and influence of online dermatologic communities have developed significantly in recent years, literature concerning the relationship between social media and dermatology grows more important. One community of interest is r/SkincareAddiction, a forum of over 1.2 million members on Reddit that serves as both a support group and discussion aggregator sourcing information from multiple social media platforms. Read More

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Prevalence of antimicrobial resistance in bacteria isolated from Great Cormorants (Phalacrocorax carbo hanedae) in Japan.

J Vet Med Sci 2021 Jun 9. Epub 2021 Jun 9.

Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University.

Wild birds are recognized as disseminators of antimicrobial-resistant (AMR) bacteria into the environment. Here, we isolated AMR indicator bacteria from 198 Great Cormorant cloacal swabs collected in Shiga (n=90), Oita (n=52), Gifu (n=29), and Gunma (n=27) Prefectures, Japan, in 2018 and 2019. In total, 198 Aeromonas spp. Read More

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Local information sources received the most attention from Puerto Ricans during the aftermath of Hurricane Maria.

PLoS One 2021 9;16(6):e0251704. Epub 2021 Jun 9.

Computational Story Lab, Vermont Complex Systems Center, The Vermont Advanced Computing Core, Department of Mathematics & Statistics, The University of Vermont, Burlington, VT, United States of America.

In September 2017, Hurricane Maria made landfall across the Caribbean region as a category 4 storm. In the aftermath, many residents of Puerto Rico were without power or clean running water for nearly a year. Using both English and Spanish tweets from September 16 to October 15 2017, we investigate discussion of Maria both on and off the island, constructing a proxy for the temporal network of communication between victims of the hurricane and others. Read More

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Characterization of the Differential Pathogenicity of Candida auris in a Galleria mellonella Infection Model.

Microbiol Spectr 2021 Jun 9:e0001321. Epub 2021 Jun 9.

Severe Infection Research Group, Health Research Institute La Fe, Valencia, Spain.

Candida auris is an emergent multidrug-resistant fungal pathogen considered a severe global threat due to its capacity to cause nosocomial outbreaks and deep-seated infections with high transmissibility and mortality. However, evidence on its pathogenicity and the complex host-pathogen interactions is still limited. This study used the invertebrate model in Galleria mellonella to assess its virulence, exploring the mortality kinetics, melanization response, and morphological changes after fungal infection compared to Candida albicans and Candida parapsilosis, with known high and low pathogenicity, respectively. Read More

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A call to action for undertaking and sharing formative evaluations of public health campaigns.

Public Health Res Pract 2021 Jun 9;31(2). Epub 2021 Jun 9.

Prevention Research Collaboration, School of Public Health, Faculty of Medicine and Health, University of Sydney, NSW, Australia; The Australian Prevention Partnership Centre, Sax Institute, Sydney, NSW.

Mass media campaigns are common interventions used in public health, but publicly available evaluations of such campaigns are few and far between, and particularly so for formative evaluations. In 2019, the Heart Foundation released a new campaign called 'Heartless Words', including a major advertisement that sparked instant controversy. In the backlash that followed, very little was said about the importance of rigorous pre-campaign formative evaluations and sharing these evaluations for the benefit of other researchers, practitioners and policy makers. Read More

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Responsive Feeding Recommendations: Harmonizing Integration into Dietary Guidelines for Infants and Young Children.

Curr Dev Nutr 2021 Jun 30;5(6):nzab076. Epub 2021 Apr 30.

Department of Nutrition and Institute for Global Nutrition, University of California at Davis, Davis, CA, USA.

Responsive feeding (RF) involves reciprocal nurturing feeding practices between the caregiver and the child that encourage the child to develop preferences for healthy foods and beverages and to eat autonomously. In this commentary, we summarize RF-related findings from a recent US National Academies of Sciences, Engineering, and Medicine (National Academies) consensus study report examining consistency in infant and young child feeding (IYCF) recommendations in guidelines from high-income countries, and we discuss implications for future IYCF guidelines. Although existing guidelines included generally consistent messages about several RF behaviors, such as the importance of encouraging self-feeding and self-regulation in infants and toddlers, they generally did not present the recommendations as part of a cohesive RF interdisciplinary framework. Read More

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Getting the First Thousand-Optimizing Instagram Residency Content to Increase Followers During the COVID-19 Pandemic.

J Educ Perioper Med 2021 Apr-Jun;23(2):E660. Epub 2021 Apr 1.

Background: Social media remains a growing platform for physicians to facilitate learning, network, and disseminate information. The Coronavirus Disease 2019 (COVID-19) pandemic has challenged traditional medical student recruitment and outreach. Instagram is a platform that can be used by residency programs to increase engagement and as a potential recruitment tool. Read More

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Georgian Med News 2021 Apr(313):79-84

1Tyumen State Medical University; Russia.

To search for effective and safe methods aimed at reducing the frequency of surgical treatment for nodular thyroid pathology. 1999-2019 literature review conducted using NLM databases. There is more and more evidence in the literature on the efficacy and safety of minimally invasive treatments for thyroid nodular disease. Read More

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Role of systems science in preventing and controlling emerging infectious diseases: protocol for a scoping review.

BMJ Open 2021 06 8;11(6):e046057. Epub 2021 Jun 8.

Centre for Public Health, Queen's University Belfast, Belfast, UK.

Introduction: In recent history, many new infectious diseases have affected humans for the first time or have appeared in previously unaffected areas of the world; these diseases are known as emerging infectious diseases (EIDs). Examples of EIDs include COVID-19, Middle East respiratory syndrome and Ebola virus disease. EIDs are known for their complexity. Read More

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Hands across Care: Art and social practice in health and elder care contexts.

Public Health 2021 Jun 5;195:135-141. Epub 2021 Jun 5.

Design & Creative Practice ECP, Digital Ethnography Research Centre, RMIT University, Melbourne, Australia.

Objectives: The convergence of socially engaged art and innovative health care was a key focus of Space and Place in End-of-Life Care, a Swedish transdisciplinary research project (2017-2020). For this project, researchers created, facilitated, and documented a range of socially engaged art and innovative healthcare practices during their exploration of the end of life in the context of Stockholm elder care residential settings.

Study Design: Formulated as a year-long transdisciplinary research residency, two or more art, design, and/or innovative healthcare researchers met in a Stockholm residential elder care home on a weekly basis to observe and encounter people and place and interact, converse, produce, and exchange knowledge in collaboration with the residents, carers, management, friends, family members, and other researchers. Read More

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Volume measurement and biophysical characterization of mounds in epithelial monolayers after intracellular bacterial infection.

STAR Protoc 2021 Jun 21;2(2):100551. Epub 2021 May 21.

Department of Biology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.

Mechanical forces are important in (patho)physiological processes, including how host epithelial cells interact with intracellular bacterial pathogens. As these pathogens disseminate within host epithelial monolayers, large mounds of infected cells are formed due to the forceful action of surrounding uninfected cells, limiting bacterial spread across the basal cell monolayer. Here, we present a protocol for mound volume measurement and biophysical characterization of mound formation. Read More

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Liar! Liar! Identifying eligibility fraud by applicants in digital health research.

Internet Interv 2021 Sep 9;25:100401. Epub 2021 May 9.

University of Virginia School of Medicine, Center for Behavioral Health & Technology, Department of Psychiatry & Neurobehavioral Sciences, 560 Ray C Hunt Dr, Charlottesville 22903, VA, USA.

Online studies enable researchers to recruit large, diverse samples, but the nature of these studies provides an opportunity for applicants to misrepresent themselves to increase the likelihood of meeting eligibility criteria for a trial, particularly those that provide financial incentives. This study describes rates of fraudulent applications to an online intervention trial of an Internet intervention for insomnia among older adults (ages ≥55). Applicants were recruited using traditional (e. Read More

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September 2021

Factors associated with gynaecological morbidities and treatment-seeking behaviour among adolescent girls residing in Bihar and Uttar Pradesh, India.

PLoS One 2021 4;16(6):e0252521. Epub 2021 Jun 4.

Department of Mathematical Demography & Statistics, International Institute for Population Sciences, Mumbai, India.

Background: Gynaecological morbidities are more common than reproductive and contraceptive morbidities and constitute a substantial proportion of disease burden in women. This study aimed to examine the prevalence and factors associated with gynaecological morbidities and the treatment-seeking behaviour among adolescent girls residing in Bihar and Uttar Pradesh, India.

Methodology: The study utilized data from the Understanding the Lives of Adolescents and Young Adults (UDAYA) survey with a sample size of 14,625 adolescents girls aged 10-19 years. Read More

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Coherent Raman scattering microscopy: capable solution in search of a larger audience.

J Biomed Opt 2021 Jun;26(6)

University of California, Irvine, Department of Biomedical Engineering, Irvine, California, United States.

Significance: Coherent Raman scattering (CRS) microscopy is an optical imaging technique with capabilities that could benefit a broad range of biomedical research studies.

Aim: We reflect on the birth, rapid rise, and inescapable growing pains of the technique and look back on nearly four decades of developments to examine where the CRS imaging approach might be headed in the next decade to come.

Approach: We provide a brief historical account of CRS microscopy, followed by a discussion of the challenges to disseminate the technique to a larger audience. Read More

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Need for Interactive Data Visualization in Public Health Practice: Examples from India.

Int J Prev Med 2021 24;12:16. Epub 2021 Feb 24.

Department of Siddhartha Medical College, Vijayawada, Andhra Pradesh, India.

The world is full of data which is increasing by leaps and bounds. In health care, big data is becoming common with increased electronic health data accumulation and/or accessibility to public data previously held under lock and key. At the same time, health data visualization applications have become popular over recent years. Read More

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February 2021