7,018 results match your criteria Disseminate and Recurrent Infundibular Folliculitis


Integrating Biological Networks for Drug Target Prediction and Prioritization.

Methods Mol Biol 2019 ;1903:203-218

Computational Biology, GSK R&D, Collegeville, PA, USA.

Computational prediction of the clinical success or failure of a potential drug target for therapeutic use is a challenging problem. Novel network propagation algorithms that integrate heterogeneous biological networks are proving useful for drug target identification and prioritization. These approaches typically utilize a network describing relationships between targets, a method to disseminate the relevant information through the network, and a method to elucidate new associations between targets and diseases. Read More

View Article
January 2019

Oral Dysbiosis in Pancreatic Cancer and Liver Cirrhosis: A Review of the Literature.

Biomedicines 2018 Dec 11;6(4). Epub 2018 Dec 11.

Fondazione Novara Sviluppo, 28100 Novara, Italy.

The human body is naturally colonized by a huge number of different commensal microbial species, in a relatively stable equilibrium. When this microbial community undergoes dysbiosis at any part of the body, it interacts with the innate immune system and results in a poor health status, locally or systemically. Research studies show that bacteria are capable of significantly influencing specific cells of the immune system, resulting in many diseases, including a neoplastic response. Read More

View Article
December 2018
1 Read

Genomic Analysis of Consecutive Strains From a Single Patient.

Front Microbiol 2018 27;9:2840. Epub 2018 Nov 27.

Department of Molecular Cell Biology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.

is one of the most important nosocomial pathogens, and thus it is required to investigate how it disseminate in hospitals and infect patients. We performed whole genome sequencing for 24 strains isolated successively from the blood of a single patient to evaluate whether repeated infections were due to re-infection or relapse infection and to investigate within-host evolution. The whole genome of the first strain, BL1, was sequenced using the PacBio RSII system. Read More

View Article
November 2018

Autologous rectus fascia sling for treatment of stress urinary incontinence in women: A review of the literature.

Neurourol Urodyn 2018 Dec 7. Epub 2018 Dec 7.

Chief Division of Female Urology, Pelvic Reconstructive Surgery & Voiding Dysfunction, Department of Urology | UC Irvine Health, Orange, California.

Aims: Stress urinary incontinence (SUI) is common in the adult females. Surgical treatment options include synthetic mid-urethral sling (MUS), autologous sling, bulking agents, and Burch colposuspension. The autologous pubovaginal sling (PVS) has re-emerged in response to complications of synthetic MUSs and FDA communications regarding the use of vaginal mesh. Read More

View Article
December 2018

Molecular Prevalence and Genetic Characterization of Toxoplasma gondii in Wild Birds in Hunan Province, China.

Vector Borne Zoonotic Dis 2018 Dec 12. Epub 2018 Dec 12.

1 Hunan Provincial Key Laboratory of Protein Engineering in Animal Vaccines, College of Veterinary Medicine, Hunan Agricultural University , Changsha, People's Republic of China .

Toxoplasma gondii is a ubiquitous apicomplexan parasite of warm-blooded animals and humans. However, limited information is available about T. gondii infection in wild birds. Read More

View Article
December 2018
1 Read

Antigen-Specific Detection of Autoantibodies Against Myeloperoxidase (MPO) and Proteinase 3 (PR3).

Methods Mol Biol 2019 ;1901:153-176

Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

ANCA testing was introduced in many laboratories throughout the world when it was recognized that a significant subset of patients with small vessel vasculopathies presented with such antibodies. Many laboratories developed and introduced in-house testing methods for antigen-specific ANCA detection complementary to indirect immune fluorescence screening. Such in-house tests have proven their merit in diagnosing vasculitis and were important to identify critical steps in the development of antigen-specific assays with high sensitivity and specificity. Read More

View Article
January 2019

The Meningococcal Cysteine Transport System Plays a Crucial Role in Survival in Human Brain Microvascular Endothelial Cells.

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

RIKEN Structural Biology Laboratory, Yokohama, Japan.

While typically exists in an asymptomatic nasopharyngeal carriage state, it may cause potentially lethal diseases in humans, such as septicemia or meningitis, by invading deeper sites in the body. Since the nutrient compositions of human cells are not always conducive to meningococci, needs to exploit nutrients from host environments. In the present study, the utilization of cysteine by the meningococcal cysteine transport system (CTS) was analyzed for the pathogenesis of meningococcal infections. Read More

View Article
December 2018
2 Reads

Pharmacotherapy in Older Adults with Cardiovascular Disease: Report from an American College of Cardiology, American Geriatrics Society, and National Institute on Aging Workshop.

J Am Geriatr Soc 2018 Dec 7. Epub 2018 Dec 7.

Cardiovascular Division, Department of Internal Medicine, Washington University, St. Louis, Missouri.

Objectives: To identify the top priority areas for research to optimize pharmacotherapy in older adults with cardiovascular disease (CVD).

Design: Consensus meeting.

Setting: Multidisciplinary workshop supported by the National Institute on Aging, the American College of Cardiology, and the American Geriatrics Society, February 6-7, 2017. Read More

View Article
December 2018

[History, purposes and characteristics of medical journals].

Authors:
Humberto Reyes B

Rev Med Chil 2018 Aug;146(8):913-920

Academia Chilena de Medicina, Chile.

Medical journals are fundamental elements in medical education, in professional life, in research and in academic careers. They communicate new scientific and clinical findings, legitimate and give credibility to biomedical and clinical investigation, are guarantors of the authors' intellectual property, are a useful forum for the discussion of relevant topics, distribute selected information to readers and are archives of their publications. Out of the numerous medical journals appeared before and during the XIXth Century, only 24 of them remain active until today and Revista Médica de Chile appears as number 20 in the list. Read More

View Article
August 2018
1 Read

Vector competence of biting midges and mosquitoes for Shuni virus.

PLoS Negl Trop Dis 2018 Dec 7;12(12):e0006993. Epub 2018 Dec 7.

Laboratory of Entomology, Wageningen University & Research, Wageningen, The Netherlands.

Background: Shuni virus (SHUV) is an orthobunyavirus that belongs to the Simbu serogroup. SHUV was isolated from diverse species of domesticated animals and wildlife, and is associated with neurological disease, abortions, and congenital malformations. Recently, SHUV caused outbreaks among ruminants in Israel, representing the first incursions outside the African continent. Read More

View Article
December 2018
1 Read

Evidence synthesis, practice guidelines and real-world prescriptions of new generation antidepressants in the treatment of depression: a protocol for cumulative network meta-analyses and meta-epidemiological study.

BMJ Open 2018 Dec 9;8(12):e023222. Epub 2018 Dec 9.

Department of Health Promotion and Human Behavior, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Introduction: Depressive disorders are the most common, burdensome and costly mental disorders. Their treatments have developed through the past decades and we now have more than a dozen new generation antidepressants, while a series of guidelines have been published to provide recommendations over the years. However, there still may exist important gaps in this evidence synthesis and implementation process. Read More

View Article
December 2018

Breast Cancer Stem Cells: Biology and Therapeutic Implications.

Int J Biochem Cell Biol 2018 Dec 5. Epub 2018 Dec 5.

National Centre for Cell Science, SP Pune University Campus, Pune 411007, India. Electronic address:

Breast cancer remains to be a dreadful disease even with several advancements in radiation and chemotherapies, owing to the drug resistance and tumor relapse caused by breast cancer stem cells. Cancer stem cells are minute population of cells of solid tumors which show self-renewal and differentiation properties as well as tumorigenic potential. Several signaling pathways including Notch, Hippo, Wnt and Hedgehog and tumor-stroma exchanges play a critical role in the self-renewal and differentiation of cancer stem cells in breast cancer. Read More

View Article
December 2018

Sexual and Gender Minority Health Research in Nursing.

Nurs Outlook 2018 Nov 2. Epub 2018 Nov 2.

School of Nursing, Columbia University, New York, NY. Electronic address:

Background: Sexual and gender minorities (SGMs) experience substantial health disparities. Evidence suggests nurses may be unprepared to work with these populations. A previous literature review of top-ranked nursing journals found that 0. Read More

View Article
November 2018

Do demographic factors and a health-promoting lifestyle influence the self-rated health of college nursing students?

BMC Nurs 2018 29;17:50. Epub 2018 Nov 29.

School of Nursing, Tung Wah College, 31 Wylie Road, Homantin, Kowloon, Hong Kong.

Background: To adopt a healthy lifestyle is considered an essential component of nursing education. Self-rated health is a subjective assessment of health status and is consistent with objective health status. Previous studies have shown an association between self-rated health and engagement in a healthy lifestyle. Read More

View Article
November 2018
1 Read

Nonverbal synchrony as a behavioural marker of patient and physician race-related attitudes and a predictor of outcomes in oncology interactions: protocol for a secondary analysis of video-recorded cancer treatment discussions.

BMJ Open 2018 Dec 4;8(12):e023648. Epub 2018 Dec 4.

Department of Oncology, School of Medicine, Wayne State University/Karmanos Cancer Institute, Detroit, Michigan, USA.

Introduction: Racial disparities in cancer treatment contribute to racial disparities in mortality rates. The quality of patient-physician communication during clinical interactions with black patients and non-black physicians (racially discordant) is poorer than communication quality with white patients (racially concordant). Patient and physician race-related attitudes affect the quality of this communication. Read More

View Article
December 2018

Measuring the Social Impact of Nursing Research: An Insight into Altmetrics.

J Adv Nurs 2018 Dec 3. Epub 2018 Dec 3.

The University of Jordan Accreditation and Quality Assurance Center.

Aims: The objectives of this study were to (1) identify nursing journal articles that provoked the most online activity and discussion and (2) assess the association between these articles' altmetric scores and publication characteristics, citation counts; and publishing journals metrics.

Background: Altmetrics, or alternative metrics, have recently emerged as a complementary way of measuring the societal impact of research by assessing the public engagement with research output. To date, no studies have yet investigated the online attention regarding scientific papers published in the nursing field. Read More

View Article
December 2018
2 Reads

White Paper: Pathways to Progress in Newborn Screening for Sickle Cell Disease in Sub-Saharan Africa.

J Trop Dis Public Health 2018 10;6(2):260. Epub 2018 Jul 10.

Department of Public Health Sciences, Loyola University Chicago Stritch School of Medicine, Maywood, IL, USA.

Sickle Cell Disease (SCD) is among the most common single-gene diseases in the world but evidence-based comprehensive health care has not been implemented where the highest prevalence of SCD occurs, in sub-Saharan Africa (SSA). It represents an urgent health burden, both in terms of mortality and morbidity with an estimated mortality of 8-16% in children under 5 years in SSA. Addressing the high mortality of SCD in SSA and for effective management of SCD, newborn screening (NBS) should be incorporated with prevention of infections (including pneumococcal septicaemia and malaria), parental education and support at all levels of healthcare provision to enable timely recognition. Read More

View Article
July 2018
1 Read

[Information System on the Safety and Effectiveness of Health Foods and Recent Topics].

Authors:
Tsuyoshi Chiba

Yakugaku Zasshi 2018 ;138(12):1517-1521

Department of Food Function and Labeling, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition.

Along with an increase in self-care and self-medication practices, the use of health foods as primary and secondary methods of disease prevention has increased. Consumers are aware only of the health benefits of dietary ingredients, although the potential risks associated with most ingredients are unknown. Adverse events associated with the use of health foods have been reported, and in some cases they were due to inappropriate use such as the concomitant use of several health foods or health foods and drugs. Read More

View Article
January 2018

[Current Status of Health Foods Including Their Interactions with Drugs and Adverse Events].

Authors:
Yoshiro Saito

Yakugaku Zasshi 2018 ;138(12):1511-1516

Division of Medicinal Safety Science, National Institute of Health Sciences.

Although many people (and patients) in Japan currently consume health foods such as supplements, few have proper knowledge of their usefulness and safety. In December 2015, the Food Safety Commission of Japan issued a report and 19 messages mainly on the safety of health foods to disseminate appropriate knowledge to consumers. The report divided health food risks into three categories: 1) risks as food (e. Read More

View Article
January 2018
1 Read

NIOSH's Respiratory Health Division: 50 years of science and service.

Arch Environ Occup Health 2018 Dec 2:1-15. Epub 2018 Dec 2.

a Respiratory Health Division , National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention , Morgantown , WV , USA.

The year 2017 marked the 50th anniversary of NIOSH's Respiratory Health Division (RHD). RHD began in 1967 as the Appalachian Laboratory for Occupational Respiratory Diseases (ALFORD), with a focus on coal workers' pneumoconiosis. ALFORD became part of NIOSH in 1971 and added activities to address work-related respiratory disease more generally. Read More

View Article
December 2018

Dissemination Using Infographic Reports Depicting Program Impact of a Community-Based Research Program: eB4CAST in iCook 4-H.

J Nutr Educ Behav 2018 Dec 1. Epub 2018 Dec 1.

School of Food and Agriculture, University of Maine, Orono, ME.

Objective: To evaluate barriers to dissemination and implementation and perceptions of the Evidence-Based Forecast Capture, Assemble, Sustain, Timelessness (eB4CAST) dissemination infographic tool as part of iCook 4-H dissemination.

Design: Online surveys and phone interviews.

Participants: Experts (n = 35) in community research completed the survey; 13 completed the interview. Read More

View Article
December 2018

The European Society of Thoracic Surgeons (ESTS) lung neuroendocrine tumors (NETs) database.

J Thorac Dis 2018 Oct;10(Suppl 29):S3528-S3532

Department of Surgical Sciences, Unit of Thoracic Surgery, University of Torino, Torino, Italy.

Histological characteristics and clinical behaviour define lung neuroendocrine tumors (NETs), which are classified into four groups: typical (TC) and atypical carcinoids (AC), large-cell neuroendocrine carcinomas (LCNCs) and small-cell lung cancers (SCLCs). Historically, outcome and treatment of these rare neoplasms have been based on small, usually mono-institutional clinical series. Furthermore, their rarity makes quite impossible to design randomised clinical trial to compare different treatments especially in unusual clinical presentations. Read More

View Article
October 2018
4 Reads

Selling the product: Strategies to increase recruitment and retention of Spanish-speaking Latinos in biomedical research.

J Clin Transl Sci 2018 Jun 21;2(3):147-155. Epub 2018 Oct 21.

Department of Statistical Sciences, Wake Forest School of Medicine.

Introduction: The Latino population in the US is rapidly growing and faces profound health disparities; however, engagement of Latinos in biomedical research remains low. Our community-based participatory research (CBPR) partnership has recruited 2,083 Spanish-speaking Latinos into 21 studies over 15 years. We sought to identify and describe the strategies we have used to successfully recruit and retain Spanish-speaking Latinos in research. Read More

View Article

Seroprevalence and risk factors of brucellosis among slaughtered indigenous cattle, abattoir personnel and pregnant women in Ngaoundéré, Cameroon.

BMC Infect Dis 2018 Dec 3;18(1):611. Epub 2018 Dec 3.

School of Veterinary Medicine and Sciences, University of Ngaoundéré, Ngaoundéré, Cameroon.

Background: Brucellosis is a neglected debilitating zoonosis with a high prevalence in many developing countries. Bovine brucellosis is widespread in Cameroon but the epidemiological situation of human brucellosis is not known. A cross sectional study was carried to determine the seroprevalence and factors associated with bovine and human Brucellosis among abattoir personnel and pregnant women in Ngaoundéré, Cameroon. Read More

View Article
December 2018

Metal wear particles in hematopoietic marrow of the axial skeleton in patients with prior revision for mechanical failure of a hip or knee arthroplasty.

J Biomed Mater Res B Appl Biomater 2018 Nov 30. Epub 2018 Nov 30.

Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois.

Wear particles generated by hip and knee arthroplasties disseminate to the liver and spleen with the highest concentrations observed in subjects who have had a failed arthroplasty. We asked to what extent metallic particles could also disseminate to remote hematopoietic bone marrow. Cored samples of red marrow from the axial skeleton and proximal humerus were obtained postmortem from four males and two females aged 79-92 years. Read More

View Article
November 2018
3 Reads

Highlights and recent developments in airway diseases in EAACI journals (2017).

Clin Transl Allergy 2018 27;8:49. Epub 2018 Nov 27.

10Transylvania University Brasov, Brasov, Romania.

The European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to support health promotion in which prevention of allergy and asthma plays a critical role and to disseminate the knowledge of allergy to all stakeholders including the EAACI junior members. There was substantial progress in 2017 in the identification of basic mechanisms of allergic and respiratory disease and the translation of these mechanisms into clinics. Read More

View Article
November 2018
1 Read

Protocol for the systematic review of research on professional learning to promote implementation of a multitiered system of support in education.

BMJ Open 2018 Nov 28;8(11):e024057. Epub 2018 Nov 28.

Department of Educational and Psychological Studies, University of South Florida, Tampa, Florida, USA.

Introduction: A multitiered system of supports (MTSS) represents a widely adopted public health approach to education in the USA. Researchers agree professional learning is critical for educators to implement the critical components of MTSS; however, professional learning approaches vary in their designs and targeted outcomes. While researchers increasingly focus their inquiries on professional learning for MTSS, no systematic research review exists. Read More

View Article
November 2018
1 Read

The relapsing fever spirochete Borrelia turicatae persists in the highly oxidative environment of its soft-bodied tick vector.

Cell Microbiol 2018 Nov 29:e12987. Epub 2018 Nov 29.

Departments of Pediatrics and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America.

The relapsing fever spirochete Borrelia turicatae possesses a complex life cycle in its soft-bodied tick vector, Ornithodoros turicata. Spirochetes enter the tick midgut during a bloodmeal, and during the following weeks spirochetes disseminate throughout O. turicata. Read More

View Article
November 2018
1 Read

A statewide training of community clinicians to treat traumatized youths involved with child welfare.

Psychol Serv 2018 Nov 29. Epub 2018 Nov 29.

Department of Psychiatry and Behavioral Sciences.

Despite considerable investment in efforts to disseminate evidence-based treatments (EBTs), few data are available on how frequently clinicians achieve competence in delivering the treatments or on whether clinical outcomes actually improve. The Louisiana Child Welfare Trauma Project (LCTP) was a 5-year demonstration project funded by the Children's Bureau. One of the aims of the LCTP was to train community clinicians statewide in an EBT for posttraumatic stress disorder (PTSD). Read More

View Article
November 2018

Improving the effectiveness of communication in hospitals for people with communication difficulties: results of an online Phase II survey.

J R Coll Physicians Edinb 2018 Dec;48(4):338-340

Royal College of Physicians of Edinburgh's Lay Advisory Committee, Royal College of Physicians of Edinburgh, Edinburgh, UK.

Background: In a recent paper a working group set up by the Lay Advisory Committee of the Royal College of Physicians of Edinburgh (RCPE) had looked into the problems of patients with severe communication difficulties in hospital (J R Coll Physicians Edinb 2017; 47: 211-3). The present online survey expands on this with the objective of garnering the views of physicians on this matter.

Method: An invitation aimed at physicians to complete an online survey was made through the recently published paper. Read More

View Article
December 2018

A mouse model of binge alcohol consumption and Burkholderia infection.

PLoS One 2018 28;13(11):e0208061. Epub 2018 Nov 28.

Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, United States of America.

Background: Binge drinking, an increasingly common form of alcohol consumption, is associated with increased mortality and morbidity; yet, its effects on the immune system's ability to defend against infectious agents are poorly understood. Burkholderia pseudomallei, the causative agent of melioidosis can occur in healthy humans, yet binge alcohol use is progressively being recognized as a major risk factor. Although our previous studies demonstrated that binge alcohol exposure results in reduced alveolar macrophage function and increased Burkholderia virulence in vitro, no experimental studies have investigated the outcomes of binge alcohol on Burkholderia spp. Read More

View Article
November 2018
1 Read

Nipah Virus Infection of Immature Dendritic Cells Increases Its Transendothelial Migration Across Human Brain Microvascular Endothelial Cells.

Front Microbiol 2018 13;9:2747. Epub 2018 Nov 13.

Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Nipah virus (NiV) can infect multiple organs in humans with the central nervous system (CNS) being the most severely affected. Currently, it is not fully understood how NiV spreads throughout the body. NiV has been shown to infect certain leukocyte populations and we hypothesized that these infected cells could cross the blood-brain barrier (BBB), facilitating NiV entry into the CNS. Read More

View Article
November 2018

Dissemination and implementation of the ICAMP.

Transl Behav Med 2018 Nov;8(6):867-875

Immunization Action Coalition, Saint Paul, MN, USA.

The current rate of immunizations for older adults does not meet the immunization goals for Healthy People 2020. Using a Social Ecological Model and Social Cognitive Theory, the purpose of this study was to disseminate and implement the Immunization Champions, Advocates and Mentors Program (ICAMP) into a variety of health care settings. This study used a single group pre-/post-test design. Read More

View Article
November 2018
2 Reads

A practical guide to developing virtual and augmented reality exercises for teaching structural biology.

Biochem Mol Biol Educ 2018 Nov 26. Epub 2018 Nov 26.

Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, 41390, Sweden.

Although virtual and augmented reality (VR and AR) techniques have been used extensively in specialized laboratories, only recently did they become affordable, reaching wider consumer markets. With increased availability, it is timely to examine the roles that VR and AR may play in teaching structural biology and in experiencing complex data sets such as macromolecular structures. This guide is suitable for those teachers of structural biology who do not have a deep knowledge of information technologies. Read More

View Article
November 2018
2 Reads

Full-genome characterization by deep sequencing of rotavirus A isolates from outbreaks of neonatal diarrhoea in pigs in Spain.

Vet Microbiol 2018 Dec 11;227:12-19. Epub 2018 Oct 11.

Departament de Sanitat i d'Anatomia Animals, Universitat Autònoma de Barcelona, 08193, Cerdanyola del Vallès, Spain; IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193, Cerdanyola del Vallès, Spain.

Since early 2017, in Spain there was an apparent increase in reports on rotavirus involvement in neonatal diarrhoea outbreaks, affecting also adult sows. In this study, 16 unrelated outbreaks of diarrhoea in suckling pigs and sows, where rotavirus A was the only pathogen detected, were investigated. Deep-sequencing was performed on total RNA from twenty-four positive faecal samples. Read More

View Article
December 2018

Process improvement strategies: Designing and implementing quality improvement research.

Semin Pediatr Surg 2018 Dec 25;27(6):379-385. Epub 2018 Oct 25.

University of Washington School of Medicine, Division of Pediatric General and Thoracic Surgery, Seattle Children's Hospital, OFFICE 4800 Sand Point Way NE, Seattle, WA 98105. MAIL M/S W-7729, PO Box 5371, Seattle, WA, 98105, USA. Electronic address:

Quality improvement (QI) is the practice of continuously evaluating and improving the quality of health care that is delivered to patients. In this article, we will use practical examples to show how quality improvement projects have improved surgical patient care, and can be shared between institutions to accelerate the pace of improvement. We will explain the differences between quality improvement and research, and describe the methodological approach to performing and reporting quality improvement projects. Read More

View Article
December 2018

Mobile app increases vegetable-based preparations by low-income household cooks: a randomized controlled trial.

Public Health Nutr 2018 Nov 26:1-12. Epub 2018 Nov 26.

Annenberg School for Communication and Journalism,University of Southern California,ASC-324-G, University Park, Los Angeles, CA 90089-0281,USA.

Objective: We built an app to help clients of food pantries. The app offers vegetable-based recipes, food tips and no-cost strategies for making mealtimes healthier and for bargain-conscious grocery shopping, among other themes. Users customize materials to meet their own preferences. Read More

View Article
November 2018

Identifying key needs for the integration of social-ecological outcomes in arctic wildlife monitoring.

Conserv Biol 2018 Nov 24. Epub 2018 Nov 24.

Centre d'Ecologie Fonctionnelle et Evolutive, UMR 5175, Centre National de la Recherche Scientifique - Université de Montpellier - Université Paul-Valéry Montpellier - EPHE, Montpellier, France.

For effective monitoring in social-ecological systems to meet needs for biodiversity, science, and humans, desired outcomes must be clearly defined and routes from direct to derived outcomes understood. The Arctic is undergoing rapid climatic, ecological, social, and economic changes and requires effective wildlife monitoring to meet diverse stakeholder needs. To identify stakeholder priorities concerning desired outcomes of arctic wildlife monitoring, we conducted in-depth interviews with 29 arctic scientists, policy and decision makers, and representatives of Indigenous organizations and NGOs. Read More

View Article
November 2018
3 Reads

Blood feeding tsetse flies as hosts and vectors of mammals-pre-adapted African Trypanosoma: current and expected research directions.

BMC Microbiol 2018 Nov 23;18(Suppl 1):162. Epub 2018 Nov 23.

Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.

Research on the zoo-anthropophilic blood feeding tsetse flies' biology conducted, by different teams, in laboratory settings and at the level of the ecosystems- where also co-perpetuate African Trypanosoma- has allowed to unveil and characterize key features of tsetse flies' bacterial symbionts on which rely both (a) the perpetuation of the tsetse fly populations and (b) the completion of the developmental program of the African Trypanosoma. Transcriptomic analyses have already provided much information on tsetse fly genes as well as on genes of the fly symbiotic partners Sodalis glossinidius and Wigglesworthia, which account for the successful onset or not of the African Trypanosoma developmental program. In parallel, identification of the non- symbiotic bacterial communities hosted in the tsetse fly gut has recently been initiated: are briefly introduced those bacteria genera and species common to tsetse flies collected from distinct ecosystems, that could be further studied as potential biologicals preventing the onset of the African Trypanosoma developmental program. Read More

View Article
November 2018

Hemodynamic shear flow regulates biophysical characteristics and functions of circulating breast tumor cells reminiscent of brain metastasis.

Soft Matter 2018 Dec;14(47):9528-9533

The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China.

Tumor cells disseminate to distant organs mainly through blood circulation, where they experience considerable levels of fluid shear flow. However, its influence on circulating tumor cells remains less understood. This study elucidates the effects of hemodynamic shear flow on biophysical properties and functions of breast circulating tumor cells with metastatic preference to brain. Read More

View Article
December 2018
8 Reads

Dynamics of Health Agency Response and Public Engagement in Public Health Emergency: A Case Study of CDC Tweeting Patterns During the 2016 Zika Epidemic.

JMIR Public Health Surveill 2018 Nov 22;4(4):e10827. Epub 2018 Nov 22.

Department of Computer Sciences, University of North Carolina at Charlotte, Charlotte, NC, United States.

Background: Social media have been increasingly adopted by health agencies to disseminate information, interact with the public, and understand public opinion. Among them, the Centers for Disease Control and Prevention (CDC) is one of the first US government health agencies to adopt social media during health emergencies and crisis. It had been active on Twitter during the 2016 Zika epidemic that caused 5168 domestic noncongenital cases in the United States. Read More

View Article
November 2018

Assessment of the environmental impact and economic benefits of the adoption of cleaner production in a Brazilian metal finishing industry.

Environ Technol 2018 Nov 22:1-15. Epub 2018 Nov 22.

c Montpellier Business School , Montpellier Research in Management , Montpellier , France.

The Metal Finishing Industry (MFI) use water and several chemicals in its production chain, which generatesboth liquid and solid hazardous waste. The present study evaluatesthe economic and environmental advantages of implementing cleaner production (CP) in a Brazilian MFI specialized in chrome and zinc. For the economic assessment, we adopted the measures of return on investment and internal rate of return. Read More

View Article
November 2018
5 Reads

Regional distribution of transpulmonary pressure.

Ann Transl Med 2018 Oct;6(19):385

Pulmonary Engineering Group, Department of Anesthesiology and Intensive Care, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

The pressure across the lung, so-called transpulmonary pressure (P), represents the main force acting toward to provide lung movement. During mechanical ventilation, P is provided by respiratory system pressurization, using specific ventilator setting settled by the operator, such as: tidal volume (V), positive end-expiratory pressure (PEEP), respiratory rate (RR), and inspiratory airway flow. Once P is developed throughout the lungs, its distribution is heterogeneous, being explained by the elastic properties of the lungs and pleural pressure gradient. Read More

View Article
October 2018
5 Reads

Almost Everything We Need to Better Serve Children of the Opioid Crisis We Learned in the 80s and 90s.

Front Public Health 2018 16;6:289. Epub 2018 Oct 16.

College of Public Health, East Tennessee State University, Johnson City, TN, United States.

Opioid use disorder impedes dependent parents' abilities to care for their children. In turn, children may languish in unpredictability and persistent chaos. Societal responses to these children are often guided by a belief that unless the drug dependent parent receives treatment, there is little help for the child. Read More

View Article
October 2018
3 Reads

Atrial Fibrillation Mechanisms and Implications for Catheter Ablation.

Front Physiol 2018 17;9:1458. Epub 2018 Oct 17.

Cardiac Electrophysiology Department, Hopital Haut Leveque, Bordeaux, France.

AF is a heterogeneous rhythm disorder that is related to a wide spectrum of etiologies and has broad clinical presentations. Mechanisms underlying AF are complex and remain incompletely understood despite extensive research. They associate interactions between triggers, substrate and modulators including ionic and anatomic remodeling, genetic predisposition and neuro-humoral contributors. Read More

View Article
October 2018
5 Reads

Comparing the Effectiveness of Clinicians and Paraprofessionals to Reduce Disparities in Perinatal Depression via the Mothers and Babies Course: Protocol for a Cluster-Randomized Controlled Trial.

JMIR Res Protoc 2018 Nov 20;7(11):e11624. Epub 2018 Nov 20.

Center for Community Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

Background: Postpartum depression is highly prevalent in low-income women and has significant health and mental health effects on mother and child. Home visiting (HV) programs provide services to large numbers of perinatal women in the United States and are a logical setting for delivering mental health services. Although there are interventions that reduce the risk of developing postpartum depression among low-income women, none have used nonhealth or nonmental health professionals as interventionists. Read More

View Article
November 2018
1 Read

Which treatment is most effective for patients with patellofemoral pain? A protocol for a living systematic review including network meta-analysis.

BMJ Open 2018 Nov 18;8(11):e022920. Epub 2018 Nov 18.

Research Unit for General Practice in Aalborg, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Introduction: Patellofemoral pain (PFP) affects 1 in every 14 adults. Many treatments for PFP have been evaluated, but the comparative effectiveness of all available treatments has never been examined. Network meta-analysis is the only design to study the comparative effectiveness of all available treatments in one synthesis. Read More

View Article
November 2018
8 Reads

The use and misuse of herbarium specimens in evaluating plant extinction risks.

Philos Trans R Soc Lond B Biol Sci 2018 Nov 19;374(1763). Epub 2018 Nov 19.

Botanic Gardens Conservation International, Richmond TW9 3BW, UK.

Herbarium specimens provide verifiable and citable evidence of the occurrence of particular plants at particular points in space and time, and are vital resources for assessing extinction risk in the tropics, where plant diversity and threats to plants are greatest. We reviewed approaches to assessing extinction risk in response to the Convention on Biological Diversity's Global Strategy for Plant Conservation Target 2: an assessment of the conservation status of all known plant species by 2020. We tested five alternative approaches, using herbarium-derived data for trees, shrubs and herbs in five different plant groups from temperate and tropical regions. Read More

View Article
November 2018
4 Reads

A core outcome set for clinical trials in whiplash-associated disorders (WAD): a study protocol.

Trials 2018 Nov 19;19(1):635. Epub 2018 Nov 19.

Recover Injury Research Centre, NHMRC Centre of Research Excellence in Recovery Following Road Traffic Injuries, The University of Queensland, Herston, QLD, Australia.

Background: Whiplash-associated disorders (WAD) as a consequence of a motor vehicle crash are a costly health burden in Western societies. Up to 50% of injured people do not fully recover. There have been numerous clinical trials and cohort studies conducted for WAD with many varied outcome measures used, making data pooling difficult and hindering meta-analysis. Read More

View Article
November 2018
2 Reads

Liquid-based endometrial cytology using SurePath is not inferior to suction endometrial tissue biopsy for detecting endometrial malignancies-Midterm report of a multicenter study advocated by Japan Association of Obstetricians and Gynecologists.

Cytopathology 2018 Nov 19. Epub 2018 Nov 19.

Director, Cancer Center, Shin-Yurigaoka General Hospital, Kanagawa, Japan.

Objective: We conducted a prospective, multicenter study to compare the clinical performance of liquid-based endometrial cytology using SurePath with that of the suction endometrial tissue biopsy. This study is officially advocated and reported by the Japan Association of Obstetricians and Gynecologists. By publishing our midterm data, we intend to disseminate the benefits of liquid-based endometrial cytology system, using the descriptive reporting format and algorithmic interpretational approach. Read More

View Article
November 2018
1 Read