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    Diagnostic Accuracy of Ga-68-HBED-CC-PSMA-Ligand-PET/CT before Salvage Lymph Node Dissection for Recurrent Prostate Cancer.
    Theranostics 2017 10;7(6):1770-1780. Epub 2017 Apr 10.
    Department of Nuclear Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
    Background: By targeting the prostate-specific membrane antigen (PSMA) on prostate cancer (PCa) cells PSMA-PET/CT shows great potential in locating the site of biochemical recurrence even at low PSA (Prostate-specific antigen)-levels. Accurate imaging of PCa recurrent lymph node metastases (LNM) is crucial for metastases directed therapies such as salvage-lymph node dissection (salvage-LND). Objective: To evaluate the diagnostic accuracy of PSMA-PET/CT for detection of affected lymph-node regions at salvage-LND for nodal recurrence of PCa. Read More

    Clinical Implications of Electrocardiograms for Patients With Type A Acute Aortic Dissection.
    Circ J 2017 May 19. Epub 2017 May 19.
    Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine.
    Type A acute aortic dissection (AAD) is a serious cardiovascular emergency requiring urgent surgery. Timely accurate diagnosis is essential, but often challenging, because of the wide spectrum of clinical presentations. In patients with type A AAD, chest pain is the most common symptom; furthermore, ischemic ST-T changes such as ST-segment elevation or depression or negative T waves are frequently observed on presentation ECG. Read More

    Endovascular Fenestration for Distal Aortic Sealing After Frozen Elephant Trunk With Thoraflex.
    Ann Thorac Surg 2017 Jun;103(6):e479-e482
    Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong. Electronic address:
    We describe a case of total arch replacement with frozen elephant trunk for chronic type B aortic dissecting aneurysm, which resulted in inadvertent landing of the frozen elephant trunk into the false lumen. A radiofrequency puncture system-assisted controlled endovascular fenestration of the dissection flap was performed at the upper abdominal aorta and subsequent thoracic endovascular stenting, successfully redirecting the blood flow from the false to the true lumen. Our case illustrated a possible way to seal distal reentry in chronic type B aortic dissection. Read More

    Transapical aortic perfusion using a deep hypothermic procedure to prevent dissecting lung injury during re-do thoracoabdominal aortic aneurysm surgery.
    J Cardiothorac Surg 2017 May 19;12(1):32. Epub 2017 May 19.
    Department of Thoracic and Cardiovascular Surgery, Graduate School of Medicine, University of the Ryukyus, Ryukyus, 207 Uehara, Nishihara, Okinawa, 903-0215, Japan.
    Background: Avoiding various complications is a challenge during re-do thoracoabdominal aneurysm surgery.

    Case Presentation: A 56-year-old man had undergone surgery for type I aortic dissection four times. The residual thoracoabdominal aortic aneurysm that had severe adhesions to lung parenchyma was resected. Read More

    Long-term durability of preserved aortic root after repair of acute type A aortic dissection.
    Gen Thorac Cardiovasc Surg 2017 May 18. Epub 2017 May 18.
    Department of Thoracic and Cardiovascular Surgery, Saga University Hospital, Saga, Japan.
    Background: Optimal management of aortic root in type A aortic dissection (AAD) is controversial. To determine the most appropriate strategy, we studied the late outcomes after conservative repair of aortic root.

    Methods: 234 AAD patients (mean age 68 ± 12 years) underwent surgical repair using supracommissural replacement (SCR) for aortic root reconstruction from 1989 to 2014. Read More

    Risk factors for continuous renal replacement therapy after surgical repair of type A aortic dissection.
    J Thorac Dis 2017 Apr;9(4):1126-1132
    Department of Cardiovascular Surgery, Beijing Anzhen Hospital of Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.
    Background: To identify the risk factors for continuous renal replacement therapy (CRRT) following surgical repair of type A aortic dissection (TAAD) using the total arch replacement and frozen elephant trunk (TAR + FET) technique.

    Methods: The study included 330 patients with TAAD repaired using TAR + FET between January 2014 and April 2015. Mean age was 47. Read More

    Survival of women with microinvasive adenocarcinoma of the cervix is not improved by radical surgery.
    Am J Obstet Gynecol 2017 May 15. Epub 2017 May 15.
    Division of Gynecologic Oncology, Department of Reproductive Medicine, University of California San Diego, Moores Cancer Center, 3855 Health Sciences Drive #0987, La Jolla, CA 92093-0987, USA.
    Background: Treatment for early-invasive adenocarcinoma of the cervix remains controversial. Although data have shown similar survival rates to those seen with squamous cell carcinoma, conservative options for patients with microinvasive adenocarcinoma have not been as widely accepted. Despite comparable survival outcomes, patients with early-invasive adenocarcinoma are still routinely subjected to more radical surgical techniques than their equivalently staged squamous cell counterparts. Read More

    Simplified Approach for Repair of Early Pseudoaneurysm of the Left Coronary Button Following Composite Graft Due to Acute Type A Aortic Dissection.
    Aorta (Stamford) 2016 Dec 1;4(6):244-247. Epub 2016 Dec 1.
    Clinic for Cardiovascular Surgery, University Hospital Bern and University of Bern, Bern, Switzerland.
    We present a simplified surgical technique that was performed on a 37-year-old man who presented with a pseudoaneurysm of the left coronary ostium two months after repair of acute Type A aortic dissection with a composite graft. Intraoperatively, the surgical sites showed extreme adhesions. The leakage at the level of the coronary suture line was exposed from inside the aortic graft. Read More

    Early Spontaneous Resolution of an Iatrogenic Acute Type A Aortic Dissection.
    Aorta (Stamford) 2016 Dec 1;4(6):235-239. Epub 2016 Dec 1.
    Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut, USA.
    Acute aortic dissection is a rare but devastating complication during cardiac catheterization. We present the case of an elderly female who incurred a Stanford Type A/DeBakey Type I acute aortic dissection extending into the arch vessels and descending aorta likely occurring during right coronary artery engagement for angioplasty. The patient was treated successfully by immediately sealing the entrance of the dissection via the placement of a stent and anti-impulse therapy. Read More

    Transient Aortic Intramural Hematoma Complicating Transaortic Valve Replacement.
    Aorta (Stamford) 2016 Dec 1;4(6):232-234. Epub 2016 Dec 1.
    Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, Minnesota, USA.
    Acute aortic intramural hematoma, which is a variant of acute aortic syndromes, most frequently occurs spontaneously and typically is treated similar to classic aortic dissection. Here, we describe a case in which an iatrogenic aortic intramural hematoma occurs shortly after transaortic valve replacement. The patient was managed conservatively, and the hematoma quickly resolved as demonstrated by serial imaging. Read More

    Conservative Management of Extensive Iatrogenic Aortic Dissection.
    Aorta (Stamford) 2016 Dec 1;4(6):229-231. Epub 2016 Dec 1.
    Divisions of Cardiac Surgery, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
    Iatrogenic aortic dissection (IAD) is a rare complication of percutaneous coronary interventions (PCI). There are no clear guidelines for IAD management, and limited data are available. Registry data and case series combined with extrapolations from our experience with spontaneous Type-A dissections suggest that very limited dissections are often managed conservatively with coronary stenting of the entry tear when possible, while more extensive dissections are managed surgically. Read More

    Spontaneous Regression of a Large Iatrogenic Dissection of the Ascending Aorta.
    Aorta (Stamford) 2016 Dec 1;4(6):226-228. Epub 2016 Dec 1.
    Cardiovascular Surgery Department, University Hospital of Lausanne, Lausanne, Switzerland.
    A 74-year-old woman was admitted for right coronary angioplasty. During the procedure, she complained about chest pain, and contrast injection showed an iatrogenic dissection of the ascending aorta. A contrast computed tomography (CT) scan confirmed the diagnosis via visualization of a large non-circulating false lumen, which involved nearly the entire ascending aorta. Read More

    David-V Procedure in a Patient with Aortic Dilation and Competent Quadricuspid Aortic Valve: Are Genetics to Blame?
    Aorta (Stamford) 2016 Oct 1;4(5):178-180. Epub 2016 Oct 1.
    Department of Cardiothoracic Surgery, The Heart Hospital Baylor Plano, Plano, Texas, USA.
    Quadricuspid aortic valves (QAVs) are extremely rare. In this case study, we report a David-V valve-sparing aortic root replacement with reimplantation of a native QAV in a patient with aortic dilation, normal valve function, and a family history of aortic dissection. Microscopic pathological examination of the excised section of the aorta revealed scattered small foci of cystic medical degeneration throughout. Read More

    Iatrogenic Supravalvular Aortic Stenosis.
    Aorta (Stamford) 2016 Oct 1;4(5):172-174. Epub 2016 Oct 1.
    Department of Cardiothoracic Surgery, Papworth Hospital, Papworth Everard, Cambridgeshire, UK.
    We describe a case of hemolytic anemia and proximal anastomotic site stenosis following emergency repair of a Type A aortic dissection. This rare complication led to a reoperation to correct the iatrogenic aortic stenosis and cure the consequent hemolysis. A "sandwich" technique (with two Teflon strips on the outside and inside of the aortic wall) was used in the initial repair to reinforce the suture line and prevent bleeding from the aortic anastomoses. Read More

    Frozen Elephant Trunk and Antegrade Visceral Debranching in the Surgical Treatment of Type B Aortic Dissection: An Alternative Method.
    Aorta (Stamford) 2016 Oct 1;4(5):167-171. Epub 2016 Oct 1.
    University of Duzce, Faculty of Medicine, Department of Cardiovascular Surgery, Duzce, Turkey.
    Intervention is inevitable in complicated Type B aortic dissections. Classical surgical procedures and endovascular interventions are far from ideal treatments due to their high risk of periprocedural complications and mortality. There is often a need for alternative method in cases of difficult anatomy. Read More

    Late Presentation of Aortic Aneurysm and Dissection Following Cardiac Catheterization.
    Cardiol Res 2017 Apr 3;8(2):68-72. Epub 2017 May 3.
    Division of Cardiology, University of South Alabama, Mobile, AL, USA.
    We report a 63-year-old female with hypertension, hyperlipidemia, and prior pacemaker insertion for atrial fibrillation with symptomatic bradycardia, who was admitted with substernal chest pressure and diaphoresis. Her electrocardiogram revealed atrial fibrillation with demand ventricular pacing and her cardiac biomarkers were negative for acute coronary syndrome. Echocardiogram revealed normal left ventricular systolic function and normal aortic root diameter. Read More

    Successful Repair of Acute Type B and Retrograde Type A Aortic Dissection With Kidney Ischemia.
    Vasc Endovascular Surg 2017 Jan 1:1538574417708133. Epub 2017 Jan 1.
    1 Department of Cardiovascular Surgery, Sanger Heart & Vascular Institute, Charlotte, NC, USA.
    Acute dissection of thoracic aorta carries a risk of renal ischemia followed by the development of a kidney failure. The optimal surgical and nonsurgical management of these patients, timing of intervention, and the factors predicting renal recovery are not well delineated and remain controversial. We present a case of acute type B thoracic aortic dissection with left kidney ischemia. Read More

    IgG4-Aortopathy: An Underappreciated Cause of Non-Infectious Thoracic Aortitis.
    Heart Lung Circ 2017 Apr 19. Epub 2017 Apr 19.
    Cardiothoracic Surgical Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.
    IgG4 related thoracic aortitis is a recent addition to the differential diagnosis for inflammatory aortic disease - a condition which is often underappreciated until complications arise such as aneurysmal formation or aortic dissection. Currently, IgG4 aortitis remains a post-surgical diagnosis reliant on positive immunohistochemistry findings. Management is guided by the extent of disease involvement, which can be gauged by serum IgG4 levels and radiological findings. Read More

    ST-segment elevation myocardial infarction could be the primary presentation of acute aortic dissection.
    Am J Emerg Med 2017 May 11. Epub 2017 May 11.
    Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, China. Electronic address:
    Background: Stanford type A aortic dissection (TAAD) may lead to coronary artery occlusion and malfunction. However, TAAD manifesting as acute ST-segment elevation myocardial infarction (STEMI) has not been studied. In the present study, we reported 8 TAAD cases with STEMI as the primary presentation, and analyzed their clinical characteristics and outcome. Read More

    Blood groups and acute aortic dissection type III.
    Arch Med Sci 2017 Apr 5;13(3):597-600. Epub 2016 May 5.
    Clinical Centre of Montenegro, Medical Faculty, University of Montenegro, Podgorica, Montenegro.
    Introduction: Acute aortic type III dissection is one of the most catastrophic events, with in-hospital mortality ranging between 10% and 12%. The majority of patients are treated medically, but complicated dissections, which represent 15% to 20% of cases, require surgical or thoracic endovascular aortic repair (TEVAR). For the best outcomes adequate blood transfusion support is required. Read More

    Admission D-dimer testing for differentiating acute aortic dissection from other causes of acute chest pain.
    Arch Med Sci 2017 Apr 20;13(3):591-596. Epub 2017 Apr 20.
    State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
    Introduction: The present study aims to evaluate the utility of D-dimer testing for differentiating the causes of acute chest pain, including acute aortic dissection (AAD), pulmonary embolism (PE), acute myocardial infarction (AMI), unstable angina (UA), and other uncertain diagnoses of chest pain.

    Material And Methods: Consecutive patients admitted for acute chest pain within 24 h from symptom onset were enrolled prospectively, and plasma D-dimer levels were measured on admission. Diagnoses of AAD, PE, AMI, and UA were confirmed by standard methods. Read More

    Medical therapy and intervention do not improve uncomplicated isolated mesenteric artery dissection outcomes over observation alone.
    J Vasc Surg 2017 May 12. Epub 2017 May 12.
    Department of Vascular Surgery, University of California, Los Angeles, Calif.
    Objective: Isolated dissection of the mesenteric vessels is rare but increasingly recognized. This study aimed to evaluate patient characteristics, primary treatment, and subsequent outcomes of mesenteric dissection using multi-institutional data.

    Methods: All patients at participant hospitals between January 2003 and December 2015 with dissection of the celiac artery (or its branches) or dissection of the superior mesenteric artery (SMA) were included. Read More

    A rare vascular complication in a patient with essential thrombocythaemia: spontaneous abdominal aortic dissection.
    Intern Med J 2017 May;47(5):589-592
    Department of Hematology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
    A 27-year-old woman complained of waist and back pain. Abdominal computed tomography angiography showed abdominal aortic dissection, the blood count revealed a high platelet count of 1655 × 10(9) /L. Negative for JAK2V617F, CALR and MPL mutations (i. Read More

    Positive family history of aortic dissection dramatically increases dissection risk in family members.
    Int J Cardiol 2017 Apr 25. Epub 2017 Apr 25.
    Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT, United States. Electronic address:
    Objectives: Although family members of patients with aortic dissection (AoD) are believed to be at higher risk of AoD, the prognostic value of family history (FH) of aortic dissection (FHAD) in family members of patients with AoD has not been studied rigorously. We seek examine how much a positive FHAD increases the risk of developing new aortic dissection (AoD) among first-degree relatives.

    Methods: Patients with AoD at our institution were analyzed for information of FHAD. Read More

    First experience with the double chimney technique in the treatment of aortic arch diseases.
    J Vasc Surg 2017 May 11. Epub 2017 May 11.
    Department of Vascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, China; Angiopathy Institute of Central South University, Changsha, China.
    Objective: The objective of this study was to summarize our initial experience using the double chimney technique to treat aortic arch diseases.

    Methods: From December 2009 to October 2016, 23 patients with aortic arch diseases, including 20 acute aortic dissections, 2 aortic arch aneurysms, and 1 type I endoleak after thoracic endovascular aortic repair (TEVAR), were treated using a double chimney technique. An emergent operation was performed in only one patient with an acute aortic dissection for severe left lower extremity ischemia. Read More

    Extensive Cerebrovascular and Visceral Artery Dissection and Pseudoaneurysm with Underlying Segmental Arterial Mediolysis.
    Ann Vasc Surg 2017 May 10. Epub 2017 May 10.
    Minneapolis Heart Institute Foundation. Electronic address:
    Segmental arterial mediolysis (SAM) is a non-atherosclerotic, non-hereditary vasculopathy that most commonly involves abdominal aortic branches and predominantly affects middle-age and elderly populations. Lysis of the outer arterial media results in separation of the media from the adventitia leading to dissecting aneurysms and/or pseudoaneurysms. We report a unique case of a 47-year-old man who presented with bilateral internal carotid artery dissection followed by dissections and aneurysms involving multiple visceral arteries. Read More

    Virtual cystoscopy, computed tomography urography and optical cystoscopy for the detection and follow-up for bladder cancer.
    Radiologia 2017 May 10. Epub 2017 May 10.
    Sección de Radiodiagnóstico, Hospital Reina Sofía, Tudela, Navarra, España.
    Objectives: To evaluate the utility of virtual cystoscopy (VC) performed with CT urography in patients being studied under gross hematuria or patients being followed-up after a previous bladder cancer and compare the results with those obtained with gold standard technique (optical cystoscopy).

    Methods: Retrospective study of 117 patients who were referred for VC by the Urology Department between May 2014 and May 2015. Those patients presented with gross hematuria or they were previously treated patients from bladder cancer being followed up. Read More

    Clinically isolated aortitis: pitfalls, progress, and possibilities.
    Cardiovasc Pathol 2017 Apr 23;29:23-32. Epub 2017 Apr 23.
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:
    Non-infectious aortitis may be caused by several distinct systemic rheumatologic diseases. In some patients, aortitis is identified either pathologically or radiologically in the absence of clinical evidence of a systemic vasculitis. By consensus nomenclature, such cases are referred to as clinically isolated aortitis (CIA). Read More

    The effect of admission serum potassium levels on in-hospital and long-term mortality in type A acute aortic dissection.
    Clin Biochem 2017 May 9. Epub 2017 May 9.
    State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 10037, China. Electronic address:
    Background: Mild fluctuations in serum potassium (K(+)) levels are related to the prognosis of cardiovascular disease. This study aimed to determine the effect of admission serum potassium levels on in-hospital and long-term mortality in patients with Stanford type A acute aortic dissection (AAD).

    Materials And Methods: A total of 588 consecutive patients with type A AAD were enrolled, and they were grouped according to admission serum potassium level: <3. Read More

    Insight into the incidence of acute aortic dissection in the German region of Berlin and Brandenburg.
    Int J Cardiol 2017 May 6. Epub 2017 May 6.
    Charité-Berlin University Medicine, Institute of Legal Medicine and Forensic Sciences, 10559 Berlin, Germany.
    Background: Stanford acute type A aortic dissection (ATAAD) is a potentially lethal condition. Epidemiology studies show a statistical incidence in Europe of approximately 2-16 cases/100,000 inhabitants/year. In Germany, the estimated incidence (here subsumed under "thoracic aortic dissection" with 4. Read More

    STEMI with fluctuating closing of LAD and Cx: Do not concentrate on the finger.
    Cardiovasc Revasc Med 2017 Mar 27. Epub 2017 Mar 27.
    Hospital Galdakao-Usansolo.
    Case report of the male with an anterior STEMI to whom a primary PCI is performed. The angiogram shows a fluctuating close of the LAD and Cx than when an OCT is performed does not clearly see any pathological findings but when the IVUS is performed, it is clearly seen as a coronary haematoma at the LM, LAD and Cx. Stent at the LM-LAD and proximal Cx are implanted with final good result. Read More

    Which technique of cusp repair is durable in reimplantation procedure?†.
    Eur J Cardiothorac Surg 2017 May 11. Epub 2017 May 11.
    Department of Cardiovascular Surgery, Kobe University Hospital, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Japan.
    Objectives: We aimed to ascertain the durability of cusp repair techniques used in reimplantation procedures.

    Methods: Between 2000 and 2015, 249 patients (mean age, 49 ± 17 years) with aortic insufficiency underwent the reimplantation procedure. The pathology was acute aortic dissection in 24 and non-dissection in 225 patients. Read More

    [Redissection of the Aortic Root Three Months after Replacement of the Ascending Aorta for Acute Stanford Type A Dissection;Report of a Case].
    Kyobu Geka 2017 May;70(5):373-376
    Department of Thoracic Surgery, Ome Municipal General Hospital, Ome, Japan.
    We report a case of redissection of the aortic root after graft replacement for acute aortic dissection using BioGlue to approximate the false lumen. A 49-year-old man underwent graft replacement of the ascending aorta for acute aortic dissection. In this operation, BioGlue was applied to the false lumen of the aortic root. Read More

    [Retrograde Type A Aortic Dissection after Thoracic Endovascular Aortic Repair;Report of a Case].
    Kyobu Geka 2017 May;70(5):369-372
    Department of Cardiovascular Surgery, Tsukuba Memorial Hospital, Tsukuba, Japan.
    A 72-year-old man presented with aneurysms of the distal aortic arch and the distal descending aorta due to chronic type B aortic dissection. We first performed thoracic endovascular aortic repair (TEVAR) in the distal descending aorta, and the aneurysm was successfully excluded using a Gore Tag stentgraft. Seven days after TEVAR, computed tomography revealed retrograde type A aortic dissection occurring from the ascending aorta to the distal aortic arch. Read More

    Trans-pericardal Color Doppler Ultra Sound (CDUS) to asses blood flow in the visceral branches during Type A dissection procedures complicated with mesenteric malperfusion.
    Ann Vasc Surg 2017 May 8. Epub 2017 May 8.
    Heart and Great Vessels Surgery Unit. Department of Medical Biotechnologies - University of Siena, Italy.
    Aortic dissection is a complex disease associated with high mortality and morbidity. Among the different possible clinical presentations, type A aortic dissection complicated at the onset by mesenteric malperfusion is characterized by poor outcome compared to patients not presenting such complication. We report the case of a patient with acute type A aortic dissection presenting with mesenteric malperfusion, in whom trans-pericardial color doppler ultra sound (CDUS) examination was used to assess intra and post-operative blood flow in the mesenteric artery. Read More

    Percutaneous Septectomy in Chronic Dissection with Abdominal Aortic Aneurysm Creates Uniluminal Neck for EVAR.
    Cardiovasc Intervent Radiol 2017 May 10. Epub 2017 May 10.
    Department of Cardiothoracic Surgery, Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford Hospital and Clinics, 300 Pasteur Drive, CVRB MC 5407, Stanford, CA, 94305, USA.
    Purpose: The intent of this report is to describe the technical details and rationale of endovascular septectomy using a wire saw maneuver in cases of chronic aortic dissection and associated infra-renal aortic aneurysm to allow standard endovascular abdominal aortic graft placement; preliminary clinical experience is also retrospectively reviewed.

    Materials And Methods: Between June 2013 and June 2016, four consecutive patients (mean age 55.3 years; range 52-58 years) with chronic type B aortic dissection and isolated infra-renal abdominal aortic aneurysm (AAA) underwent endovascular aneurysm repair (EVAR) following guidewire septectomy to create a suitable proximal aortic landing zone. Read More

    [Lotus Sadra valve implantation complicated by type B aortic dissection: diagnosis and treatment].
    G Ital Cardiol (Rome) 2017 Apr;18(4):325-328
    U.O.C. Cardiologia Interventistica, AORN dei Colli-Monaldi, Napoli.
    Transcatheter aortic valve implantation (TAVI) is a validated technique for the treatment of aortic valve stenosis in patients with high surgical risk or inoperable. We present the case of an 80-year-old woman with severe aortic valve stenosis (mean gradient 55 mmHg), mild surgical risk, who refused traditional surgery. We implanted a Lotus Sadra 25 mm (Boston Scientific, Marlborough, MA, USA) via the transfemoral route. Read More

    [The spiral of evil: iatrogenic coronary and aortic dissection].
    G Ital Cardiol (Rome) 2017 Apr;18(4):322-324
    Dipartimento Cardiovascolare, ASST Papa Giovanni XXIII, Bergamo.
    Iatrogenic coronary and aortic dissection is one of the worst complication during a percutaneous coronary intervention. Nevertheless, it can be approached and effectively resolved by a percutaneous way, sealing the false lumen "entry door" with a covered stent, even if this device is more thrombogenic than other bare-metal or drug-eluting stents. We report the case of a 60-year-old man with acute ST-elevation myocardial infarction complicated by both iatrogenic dissection and multiple stent thrombosis. Read More

    Update on the management of giant cell arteritis.
    Ther Adv Chronic Dis 2017 Apr 28;8(4-5):69-79. Epub 2017 Mar 28.
    Division of Rheumatology, Department of Medicine, University of Alberta, 8-130K Clinical Sciences Building, Edmonton, AB, T6G 2G3, Canada.
    Giant cell arteritis (GCA) is a large vessel vasculitis that may be associated with significant complications such as blindness, stroke, or aortic aneurysm and dissection in a subset of patients. Given the serious side effects associated with prolonged courses of glucocorticoids and frequent relapses experienced when doses are tapered, increased efforts are being dedicated to the discovery of safer and more effective therapies to control this disease. The purpose of this review is to critically evaluate the role of glucocorticoid-sparing agents in the medical management of GCA with a special focus on the most recent evidence regarding the role of biologic agents, including tocilizumab (TCZ), abatacept and ustekinumab, and other novel therapies. Read More

    Contemporary natural history of bicuspid aortic valve disease: a systematic review.
    Heart 2017 May 10. Epub 2017 May 10.
    Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA.
    We performed a systematic review of the current state of the literature regarding the natural history and outcomes of bicuspid aortic valve (BAV). PubMed and the reference lists of the included articles were searched for relevant studies reporting on longitudinal follow-up of BAV cohorts (mean follow-up ≥2 years). Studies limited to patients undergoing surgical interventions were excluded. Read More

    Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms.
    J R Soc Interface 2017 May;14(130)
    Department of Biomedical Engineering, Yale University, New Haven, CT, USA
    Thoracic aortic aneurysms are life-threatening lesions that afflict young and old individuals alike. They frequently associate with genetic mutations and are characterized by reduced elastic fibre integrity, dysfunctional smooth muscle cells, improperly remodelled collagen and pooled mucoid material. There is a pressing need to understand better the compromised structural integrity of the aorta that results from these genetic mutations and renders the wall vulnerable to dilatation, dissection or rupture. Read More

    Aortic dissection and cystinosis: is there any relationship?
    Cardiol Young 2017 May 11:1-3. Epub 2017 May 11.
    Tehran Heart Center and School of Medicine,Tehran University of Medical Sciences,Tehran,Iran.
    Cystinosis is a rare, autosomal-recessive genetic disorder. The kidneys are commonly involved, as there is cystinosin protein malfunction, and nephropathic cystinosis ensues. Although cardiac and vascular involvements are rare, we describe a unique case of aortic dissection in a 25-year-old female with cystinosis. Read More

    The Candy-Plug Technique: Technical Aspects and Early Results of a New Endovascular Method for False Lumen Occlusion in Chronic Aortic Dissection.
    J Endovasc Ther 2017 May 1:1526602817709252. Epub 2017 May 1.
    1 German Aortic Center Hamburg, Department of Vascular Medicine, University Heart Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
    Purpose: To describe the technical aspects and early results of the Candy-Plug technique for endovascular false lumen occlusion in chronic aortic dissection.

    Methods: A retrospective single-center study analyzing 18 consecutive patients (mean age 63 years, range 44-76; 16 men) with thoracic false lumen aneurysm in chronic aortic dissection. All patients underwent thoracic endovascular aortic repair with false lumen occlusion using the Candy-Plug technique. Read More

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