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Kidney Int 2021 May 4. Epub 2021 May 4.

Department of Cardiology I: Coronary and Peripheral Vascular Disease, Heart Failure, Münster University Hospital, Münster, Germany. Electronic address:

Chronic kidney disease (CKD) affects about 10% of all populations worldwide, with about 2 million people requiring dialysis. Although patients with CKD are at high risk of cardiovascular disease (CVD) and events, they are often underrepresented or excluded in clinical trials, leading to important knowledge gaps about how to treat these patients. KDIGO (Kidney Disease: Improving Global Outcomes) convened the fourth Clinical Controversies Conference on the Heart, Kidney and Vasculature in Dublin, Ireland, in February 2020, entitled "Central and Peripheral Arterial Diseases in Chronic Kidney Disease. Read More

Anatol J Cardiol 2021 May;25(5):E21

Department of Cardiovascular Surgery, Mugla Sitki Kocman University, Mugla.

J Cardiovasc Pharmacol 2021 May 5. Epub 2021 May 5.

Department of Emergengcy, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, Henan 450000, P.R. China Department of Emergengcy, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, Henan 450000, P.R. China Department of Emergengcy, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, Henan 450000, P.R. China Department of Emergengcy, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, Henan 450000, P.R. China Department of Emergengcy, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, Henan 450000, P.R. China Department of Emergengcy, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, Henan 450000, P.R. China Department of Emergengcy, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, Henan 450000, P.R. China Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, Henan 450000, P.R. China.

Abstract: Vascular smooth muscle cell (VSMC) dysfunction is the main cause of aortic dissection (AD). In this study, we focused on the role and mechanism of miR-4787-5p in regulating VSMC apoptosis. RT-qPCR was used to detect the expression of miR-4787-5p in aorta tissues of AD (n=10) and normal aortic tissues of donors (n=10). Read More

J Vasc Surg 2021 May 3. Epub 2021 May 3.

Department of Surgery, Division of Vascular Surgery, University of California-Davis Medical Center, Sacramento, CA.

Objectives: The advent of thoracic single side-branched endograft (TSSBE) provides a treatment option to obviate the need for open cervical debranching of the left subclavian artery (LSA), thereby enabling total endovascular incorporation of the LSA during thoracic endovascular aortic repair (TEVAR). In a previous study in patients with type B aortic dissection who required zone 2 TEVAR, anatomic feasibility of this device has been demonstrated to range between 28% and 35%, suggesting limited applicability of currently available designs. The objective of this study was twofold: (1) to evaluate the anatomic feasibility of TSSBE in blunt traumatic thoracic aortic injury (BTAI) patients who would require LSA revascularization; and (2) to describe the anatomical characteristics of the supra-aortic arch branches that can be used to improve future device design. Read More

Eur J Cardiothorac Surg 2021 May 6. Epub 2021 May 6.

Department of Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, Bad Krozingen, Germany.

Objectives: Our goal was to evaluate results of endovascular aortic arch repair using the Relay Branch system.

Methods: Forty-three patients with thoracic aortic pathology involving the aortic arch have been treated with the Relay Branch system (Terumo Aortic, Sunrise, FL, USA) in 10 centres. We assessed in-hospital mortality, neurological injury, treatment success according to current reporting standards and the need for secondary interventions. Read More

Blood Coagul Fibrinolysis 2021 Jun;32(4):253-258

Department of Cardiothoracic Surgery, Clinical Sciences, Lund University, Skane University Hospital, Lund, Sweden.

Excessive bleeding is a serious complication associated with impaired survival after surgery for acute type A aortic dissection (ATAAD). Different ABO blood groups are associated with variable levels of circulating von Willebrand factor and therefore potentially altered risks of surgical haemorrhage. The current study aimed to assess the impact of blood group on bleeding complications after ATAAD surgery. Read More

Angiology 2021 May 6:33197211012514. Epub 2021 May 6.

Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Lymphocyte-related blood parameters (LRBP), including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio, and lymphocyte-monocyte ratio, could reflect a patient's overall inflammatory status. We aimed to clarify the association between preoperative LRBP and outcomes of type B aortic dissection (TBAD) patients undergoing thoracic endovascular aortic repair (TEVAR). A total of 841 patients were enrolled from 2010 to 2017. Read More

Comput Math Methods Med 2021 12;2021:6697848. Epub 2021 Apr 12.

Graduate School of Peking Union Medical College, Beijing, China.

Background: Acute type A aortic dissection (ATAAD) is one of the most lethal cardiovascular diseases, and its molecular mechanism remains unclear.

Methods: Differentially expressed genes (DEGs) between ATAAD and control were detected by limma R package in GSE52093, GSE153434, GSE98770, and GSE84827, respectively. The coexpression network of DEGs was identified by the WGCNA package. Read More

Surg Neurol Int 2021 14;12:164. Epub 2021 Apr 14.

Department of Neurosurgery, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota, United States.

Background: Melanotic schwannoma (MS) is a rare variant of peripheral nerve sheath tumor. MS commonly arises along the spinal nerve sheath. Patients most often experience pain along the dermatome of the affected nerve root. Read More

Asian Cardiovasc Thorac Ann 2021 May 4:2184923211015087. Epub 2021 May 4.

Aortovascular Surgery, Barts Heart Centre, St. Bartholomew's Hospital, London, UK.

Acute type A aortic dissection is a surgical emergency with a high mortality rate if left untreated. Management of the aortic root in this setting constitutes an intricate decision-making framework, further complicated by the emergent nature of the dissection. There exists much controversy regarding pursuit of the aggressive aortic root replacement versus a conservative root-sparing repair, alongside considerations for valve-sparing root replacement. Read More

Heart Lung Circ 2021 Apr 30. Epub 2021 Apr 30.

Nagoya University Graduate School of Medicine, Department of Cardiac Surgery, Nagoya, Aichi, Japan.

Surgical outcomes for acute Type A aortic dissection (AAD) have dramatically improved in recent years due to prompt diagnosis, improved surgical technique and perioperative management. A single needle hole can become a new entry point in AAD cases with such a fragile wall, so a mixed technique using minimal surgical stitches and glue is required for a good outcome. The 'Millefeuille' technique involves multiple layers with a prosthetic graft, intimal layer, additionally inserted surplus intimal layer with BioGlue, adventitial layer, and felt. Read More

J Thorac Cardiovasc Surg 2021 Apr 9. Epub 2021 Apr 9.

Division of Cardiovascular Surgery, Japanese Red Cross Kobe Hospital and Hyogo Emergency Medical Center, Kobe, Japan. Electronic address:

Objectives: We analyzed patients with acute type A aortic dissection complicated by malperfusion syndrome to establish whether the timing of operative treatment and the location of malperfusion are factors in determining outcomes.

Methods: A total of 331 patients with acute type A aortic dissection were treated surgically between August 2003 and May 2019. Eighty-four patients (25%) presented with preoperative malperfusion syndrome. Read More

J Vasc Surg 2021 Apr 30. Epub 2021 Apr 30.

Imperial Vascular Unit, Imperial College Healthcare NHS Trust, London, UK; Department of Interventional Radiology, Imperial College Healthcare NHS Trust, London, UK. Electronic address:

Introduction: Thoracic endovascular aortic repair with a scallop design (scallop-TEVAR) is a useful treatment strategy to extend the proximal landing zone (PLZ), whilst maintaining perfusion to one or more of the supra-aortic trunks when treating aortic pathology with an unfavourable PLZ. The durability of this approach with the Bolton Relay scallop endograft (Terumo Aortic, Sunrise, Florida, United States) has not been established.

Methods: A retrospective review of prospectively collected data on consecutive patients that received scallop-TEVAR in zones 0-2 at a tertiary aortic unit was undertaken. Read More

J Vasc Surg 2021 Apr 30. Epub 2021 Apr 30.

Division of Vascular Surgery, Stanford University, Stanford, CA, United States of America.

Objective: Thoracic endovascular aortic repair (TEVAR) can change the morphology of the flow lumen in aortic dissections, which may affect aortic hemodynamics and function. This study characterizes how helical morphology of the true lumen in type B aortic dissections is altered by TEVAR.

Methods: Patients with type B aortic dissection who underwent computed tomography angiography pre- and post-TEVAR were retrospectively reviewed. Read More

J Vasc Surg 2021 Apr 30. Epub 2021 Apr 30.

Division of Vascular Surgery and Endovascular Therapy, Keck Medical Center of USC, Los Angeles, CA. Electronic address:

Objective: Aortic dissection can result in devastating cerebral, visceral, renal, spinal, and extremity ischemia. We describe the management and outcomes of patients presenting with aortic dissection and lower extremity malperfusion.

Methods: A single-center institutional aortic database was queried for patients with aortic dissection and lower extremity malperfusion (LEM) from 2011-2019. Read More

Ann Card Anaesth 2021 Jan-Mar;24(1):83-86

Department of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Iatrogenic aortic dissection is a rare and serious complication of cardiac surgery with an incidence between 0.12' and 0.16'. Read More

J Card Surg 2021 May 3. Epub 2021 May 3.

Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

A 63-year-old man was admitted to our hospital owing to the shortness of breath. He had undergone ascending aortic repair for acute type-A aortic dissection 14 years ago. In the previous surgery, the primary entry of the ascending aorta had been resected using direct end-to-end anastomosis after transecting the ascending aorta at the level of the entry and gluing the false lumen using a gelatin-resorcin-formalin glue. Read More

J Card Surg 2021 May 3. Epub 2021 May 3.

Department of Vascular and Endovascular Surgery, Royal Blackburn Teaching Hospital, Blackburn, UK.

EJVES Vasc Forum 2020 6;49:11-15. Epub 2020 Sep 6.

Advanced Aortic Research Program at the University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.

Introduction: Fenestrated branched endovascular aortic repair with custom manufactured devices (CMDs) has been applied to treat post-dissection thoraco-abdominal aortic aneurysms (TAAA), but the long waiting period for device manufacture limits its application in symptomatic or contained ruptured aneurysms.

Report: A 59 year old female presented with a 7 cm chronic post-dissection extent II TAAA. The patient underwent first stage total arch repair with the elephant trunk technique. Read More

EJVES Vasc Forum 2020 29;48:1-4. Epub 2020 May 29.

Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, Saga University, Saga, Japan.

Introduction: The efficacy of endovascular treatment for complicated Stanford type B acute aortic dissection is being established. However, aortic events sometimes occur, and some cases require surgical intervention.

Report: A 52 year old man underwent ascending aorta replacement for Stanford type A acute aortic dissection in August 2016. Read More

J Vasc Surg Cases 2015 Mar 18;1(1):9-12. Epub 2015 Mar 18.

Division of Vascular Surgery, Department of Surgery, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada.

Congenital saccular aneurysms of the inferior vena cava (IVC) are extremely rare, with 23 cases reported so far. We present a case of a 55-year-old woman with an acute episode of back pain that mimicked aortic dissection. Computed tomography ruled out aortic dissection but demonstrated a saccular aneurysm of the infrarenal IVC and a circumaortic left renal vein. Read More

Front Cardiovasc Med 2021 15;8:638420. Epub 2021 Apr 15.

Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

This study employed three surgical techniques: total arch replacement (TAR) with frozen elephant trunk (FET), aortic balloon occlusion technique (ABO) and hybrid aortic arch repair (HAR) on patients with type I aortic dissection in Fuwai Hospital, aiming to compare the early outcomes of these surgical armamentariums. From January 2016 to December 2018, an overall 633 patients (431 of TAR+FET, 122 of HAR, and 80 of ABO) with type I aortic dissection were included in the study. Thirty-day mortality, stroke, paraplegia, re-exploration for bleeding, and renal replacement therapy were compared using the matching weight method (MWM). Read More

Front Oncol 2021 15;11:654285. Epub 2021 Apr 15.

Gynecological Oncology Unit, La Paz University Hospital, Madrid, Spain.

Objective: To evaluate the role of sentinel lymph node biopsy (SLNB) to avoid staging lymphadenectomies by detecting nodal metastasis in intermediate- and high-risk endometrial cancer (EC).

Methods: A single institutional retrospective study was performed including all patients with intermediate- and high-risk EC who underwent surgical nodal staging between January 2012 and December 2019. Patients with disseminated disease detected on imaging techniques or at the time of surgery were excluded. Read More

Quant Imaging Med Surg 2021 May;11(5):1723-1736

Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Background: The study aims to analyze the correlation between the maximal diameter (both axial and orthogonal) and volume changes in the true (TL) and false lumens (FL) after stent-grafting for Stanford type B aortic dissection.

Method: Computed tomography angiography was performed on 13 type B aortic dissection patients before and after procedure, and at 6 and 12 months follow-up. The lumens were divided into three regions: the stented area (Region 1), distal to the stent graft to the celiac artery (Region 2), and between the celiac artery and the iliac bifurcation (Region 3). Read More

J Saudi Heart Assoc 2021 19;33(1):85-94. Epub 2021 Apr 19.

Cardiovascular Medicine Department, Cairo University, Cairo, Egypt.

Introduction: Computed Tomography (CT) scan is a helpful tool to assess the coronary arteries and the great vessels. However, its routine use in the assessment of patients with suspected prosthetic valve dysfunction (PVD) has not been studied thoroughly.

Objective: To determine the impact of routine cardiac computed tomography angiography (CCTA) on diagnostic and therapeutic decisions in patients with suspected PVD. Read More

J Thorac Cardiovasc Surg 2021 Apr 3. Epub 2021 Apr 3.

University Clinic of Cardiac Surgery, Leipzig Heart Centre, Leipzig, Germany. Electronic address:

J Thorac Cardiovasc Surg 2021 Mar 31. Epub 2021 Mar 31.

Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Florida, Gainesville, Fla. Electronic address:

Objectives: Deep hypothermic circulatory arrest (DHCA) is often required for patients undergoing repair of descending thoracic aortic aneurysm (DTAA) or thoracoabdominal aortic aneurysm via left thoracotomy when proximal crossclamping is not feasible or when aneurysmal disease extends into the transverse aortic arch. Historical literature suggests higher complications rates due to the technical complexity of this approach; we examined outcomes with this approach at our center.

Methods: Between January 2008 and May 2018, 84 patients with DTAA or Crawford extent I thoracoabdominal aortic aneurysm underwent open repair. Read More

Orv Hetil 2021 05 2;162(18):696-704. Epub 2021 May 2.

1 Semmelweis Egyetem, Általános Orvostudományi Kar, Városmajori Szív- és Érgyógyászati Klinika, Budapest, Városmajor u. 68., 1122.

Összefoglaló. Bevezetés: A Marfan-szindróma autoszomális domináns módon öröklődő, szisztémás kötőszöveti betegség. A hosszú távú túlélés szempontjából fontos a nagyérkatasztrófák megelőzése. Read More

J Cardiothorac Surg 2021 May 1;16(1):117. Epub 2021 May 1.

Department of Cardiovascular Surgery and Cardiac Disease Center, Union Hospital, Fujian Medical University, Fuzhou, 350001, P. R. China.

Background: To compare postoperative sexual dysfunction (SD) and quality of life (QOL) in Type A Aortic Dissection (AAD) Patients of Different Ages.

Methods: From January 2018 to December 2019, 204 AAD postoperative survivors in Union Hospital of Fujian Medical University were selected and were divided into young group (less than 50 years old) and elderly group (more than 50 years old). We evaluated SD according to the male International Erectile Dysfunction Index (IIEF-5) and female sexual function index (FSFI). Read More

Clin Neurol Neurosurg 2021 Apr 20;205:106647. Epub 2021 Apr 20.

Department of Neurosurgery, University of Iowa, Carver College of Medicine, The University of Iowa, USA.

A 43-year-old woman presented to the hospital with severe low back pain and paresthesias in the bilateral lower extremities. MRI of the spine revealed spinal subarachnoid and subdural hemorrhage extending from T11 to L5-S1. A diagnostic spinal angiogram demonstrated a dissecting, partially thrombosed aneurysm of the artery of Adamkiewicz. Read More