1,205 results match your criteria Disorders of Oral Pigmentation


Combination of oral methotrexate and oral mini-pulse dexamethasone versus either agent alone in vitiligo treatment with follow up by dermoscope.

Dermatol Ther 2020 May 14:e13586. Epub 2020 May 14.

Resident Dermatologist.

This study aimed to compare the efficacy and safety of oral methotrexate (MTX) and oral mini-pulse (OMP) dexamethasone alone and in combination in the treatment of vitiligo. PATIENTS AND METHODS: A total of 42 patients with vitiligo were included in the study. The patients were treated for three months and randomly assigned into three groups including 14 patients each: group A received oral MTX, group B received OMP dexamethasone, and group C received a combination of both. Read More

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http://dx.doi.org/10.1111/dth.13586DOI Listing

Oral manifestations associated with antimalarial therapy in patients with systemic lupus erythematosus.

Lupus 2020 May 3:961203320922620. Epub 2020 May 3.

Institute of Biomedicine, Faculty of Medicine, Central University of Venezuela, Caracas, Venezuela.

Introduction: Lupus erythematosus (LE) is an autoimmune disease often treated with antimalarial drugs. The prolonged use of chloroquine and hydroxychloroquine can cause hyperpigmentation in the skin, oral mucosa and retinal pigment epithelium, which in turn can trigger toxicity in this epithelium, which in some cases causes vision loss. The objective of the present work was to establish the association between the presence of oral pigmented macules by antimalarial and secondary retinal toxicity. Read More

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http://dx.doi.org/10.1177/0961203320922620DOI Listing

Repeated Orotracheal Intubation in Mice.

J Vis Exp 2020 Mar 27(157). Epub 2020 Mar 27.

Department of Veterinary Biosciences, The Ohio State University;

The literature describes several methods for mouse intubation that either require visualization of the glottis through the oral cavity or incision in the ventral neck for direct confirmation of cannula placement in the trachea. The relative difficulty or the tissue trauma induced to the subject by such procedures can be an impediment to an investigator's ability to perform longitudinal studies. This article illustrates a technique in which physical manipulation of the mouse following the use of a depilatory to remove hair from the ventral neck permits transcutaneous visualization of the trachea for orotracheal intubation regardless of degree of skin pigmentation. Read More

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http://dx.doi.org/10.3791/60844DOI Listing

LASER Assisted Excision of Solitary Neurofibroma in the Gingiva.

Cureus 2020 Feb 27;12(2):e7118. Epub 2020 Feb 27.

Periodontology, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.

Neurofibromatosis (NF) is a genetic disorder that presents as benign tumours of the nervous system originating from the nerve sheath. It is of three types: Type I, Type II and Schwannomatosis. Type I Neurofibromatosis or von Recklinghausen's disease is the most common type of neurofibromatosis seen and it accounts for 90% of all cases seen. Read More

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http://dx.doi.org/10.7759/cureus.7118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105066PMC
February 2020

Differences in the Incidence of Pathologic Lesions on the Oral Mucosa in Patients Undergoing Hemodialysis vs Renal Organ Transplant Recipients Subjected to Long-term Pharmacologic Immunosuppressive Therapy.

Transplant Proc 2020 Mar 25. Epub 2020 Mar 25.

Department of General and Transplantation Surgery, Medical University of Warsaw, Warsaw, Poland.

Disorders of homeostasis and an increased incidence of infection in patients undergoing hemodialysis causes frequent appearance of pathologic changes in the oral mucosa. The organ transplant and subsequent pharmacologic immunosuppression may result in systemic disorders manifesting by pathologic oral lesions.

Methods: The study was conducted on 18 patients undergoing hemodialysis and 18 patients after renal transplant. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.02.105DOI Listing

Secondary hemosiderosis presented by porphyria cutanea tarda in a kidney dialysis patient: A case report.

SAGE Open Med Case Rep 2020 22;8:2050313X20907815. Epub 2020 Feb 22.

Pathology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

A 68-year-old woman with chronic kidney disease receiving dialysis and iron supplementation presented to our hospital with painful blisters, fragile skin, and changes to skin pigmentation on the dorsal side of both upper and lower limbs. Skin biopsy findings and an increase in urine porphyrins confirmed the diagnosis of porphyria cutanea tarda. Upon examination, extremely high serum ferritin levels (6000 µg/L) suggested iron overload. Read More

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http://dx.doi.org/10.1177/2050313X20907815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036493PMC
February 2020

SG-SP1 Suppresses Mast Cell-Mediated Allergic Inflammation via Inhibition of FcεRI Signaling.

Front Immunol 2020 28;11:50. Epub 2020 Jan 28.

CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, South Korea.

As the number of allergic disease increases, studies to identify new treatments take on new urgency. Epigallocatechin gallate (EGCG), a major component of green tea, has been shown to possess a wide range of pharmacological properties, including anti-inflammation and anti-viral infection. In previous study, gallic acid (GA), a part of EGCG, has shown anti-allergic inflammatory effect. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998798PMC
January 2020

Inhibitory effects of orientin in mast cell-mediated allergic inflammation.

Pharmacol Rep 2020 Jan 24. Epub 2020 Jan 24.

Cell and Matrix Research Institute, Department of Pharmacology, School of Medicine, Kyungpook National University, 680, Gukchaebosang-ro, Jung-gu, Daegu, 41944, Republic of Korea.

Background: Mast cells are immune effector cells mediating allergic inflammation by the secretion of inflammatory mediators such as histamine and pro-inflammatory cytokines. Orientin is a naturally occurring bioactive flavonoid that possesses diverse biological properties, including anti-inflammation, anti-oxidative, anti-tumor, and cardio protection. The objective of this study was to rule out the effectiveness of orientin in mast cell-mediated allergic inflammation. Read More

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http://dx.doi.org/10.1007/s43440-019-00048-3DOI Listing
January 2020
1.928 Impact Factor

Oral and nail pigmentations: a useful parallelism for the clinician.

J Dtsch Dermatol Ges 2020 Jan 17;18(1):7-14. Epub 2020 Jan 17.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Oral (OP) and nail (NP) pigmentations may occur simultaneously in physiological or pathological conditions, and may be a sign of underlying syndromic conditions that necessitate further investigation and treatment. Interestingly, the nail unit and oral cavity show a clinical parallelism that may help the clinician to conduct a correct examination and reach a prompt diagnosis. Both OP and NP can manifest clinically with focal or diffuse involvement and are due to external factors (exogenous pigmentation, drug-induced pigmentation) or endogenous factors (racial pigmentation, post-inflammatory pigmentation, nevi, genetic conditions and other disorders). Read More

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http://dx.doi.org/10.1111/ddg.14023DOI Listing
January 2020

The High Content of 11α-hydroxy-15-oxo-kaur- 16-en-19-oic Acid in (L.) O. Kuntze Leaf Extract: With Preliminary in Vivo Assays.

Foods 2020 Jan 9;9(1). Epub 2020 Jan 9.

Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

Background: 11α-hydroxy-15-oxo-kaur-16-en-19-oic acid (11αOH-KA) is a multifunctional biochemical found in some ferns, , and its congeneric species. Although a number of therapeutic applications of 11αOH-KA have been proposed (e.g. Read More

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http://dx.doi.org/10.3390/foods9010073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022889PMC
January 2020

Persistent dermatomal eruption on a leg.

Dermatol Online J 2019 Oct 15;25(10). Epub 2019 Oct 15.

Department of Dermatology, Austin Regional Clinic, Austin, TX Department of Dermatology, Mayo Clinic, Jacksonville, FL.

Unilateral linear capillaritis (ULC) is a rare variant of pigmented purpuric dermatoses (PPD) that is characterized by a linear or pseudo-dermatomal eruption on a single extremity. Although clinically distinct from the other PPD, it shares histopathologic features with this group. Herein, we present a man in his 50s who presented with asymptomatic macules and scaly papules on the left lower extremity in a linear distribution. Read More

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October 2019

Mucocutaneous and nail pigmentation in an elderly woman.

Eur J Dermatol 2019 Aug;29(4):450-451

Department of Dermatology, Hospital de Braga, R. Sete Fontes, 4710, Braga, Portugal.

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http://dx.doi.org/10.1684/ejd.2019.3616DOI Listing

New records of Batrachochytrium dendrobatidis in the state of Bahia, Brazil: histological analysis in anuran amphibian collections.

Dis Aquat Organ 2019 Oct;136(2):147-155

Institute of Biology, Federal University of Bahia - UFBA, Rua Barão de Jeremoabo, s/n, Ondina Campus, CEP 40170-115, Salvador, Bahia, Brazil.

Infection caused by the fungus Batrachochytrium dendrobatidis (Bd) produces chytridiomycosis, a disease considered one of the main causes of amphibian population declines in the world. In Brazil, Bd has been recorded in several regions, but mainly in the Atlantic Forest biome. This study aimed to investigate the occurrence of Bd in amphibian species in Bahia State to test the hypothesis that Bd is widespread in other Brazilian biomes. Read More

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http://dx.doi.org/10.3354/dao03402DOI Listing
October 2019
2 Reads

Management of Lip Complications.

Facial Plast Surg Clin North Am 2019 Nov;27(4):565-570

Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, 550 First Avenue, NBV 5E5, New York, NY 10016, USA. Electronic address:

This article discusses complications that may occur after procedures on the lips, specifically focusing on injectable fillers. Evidence-based guidelines and suggested methods to manage these complications are presented in a systematic format. Read More

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http://dx.doi.org/10.1016/j.fsc.2019.07.011DOI Listing
November 2019
2 Reads

Paclitaxel-related nail toxicity.

Taiwan J Obstet Gynecol 2019 Sep;58(5):709-711

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address:

Objective: Nail change after chemotherapy is relatively unfamiliar with gynecological oncologist. It often occurs after docetaxel treatment. For gynecological tract cancers, paclitaxel might be most frequently used but nail change after paclitaxel treatment is seldom reported before. Read More

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http://dx.doi.org/10.1016/j.tjog.2019.07.023DOI Listing
September 2019
2 Reads

An Oral Supplement and the Nutrition-Skin Connection.

J Clin Aesthet Dermatol 2019 Jul 1;12(7):13-16. Epub 2019 Jul 1.

Dr. Draelos is with Dermatology Consulting Services, PLLC in High Point, North Carolina.

The relationship between good nutrition and skin health has been difficult to scientifically document. While the minimum daily allowances of nutrients to prevent disease have been established, the optimal nutritional state for skin health is unknown. This single-site, double-blind, placebo-controlled study enrolled 50 female subjects, aged 35 to 65 years, with mild-to-moderate photoaging and stable prescription medication usage for three months prior to study enrollment. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715334PMC
July 2019
1 Read

Therapeutic Insights in Melasma and Hyperpigmentation Management

J Drugs Dermatol 2019 Aug;18(8):718-729

Melasma and postinflammatory hyperpigmentation (PIH) are the most common forms of dyschromia in patients with skin of color. Both are associated with a high psychological burden of disease. To exacerbate this burden, the need for treatment is chronic, and the results are often suboptimal in the eyes of the patient. Read More

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August 2019
3 Reads

Fungal melanonychia caused by Candida parapsilosis successfully treated with oral fosravuconazole.

J Dermatol 2019 Oct 25;46(10):911-913. Epub 2019 Jul 25.

Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

A 73-year-old healthy woman noticed black pigmentation on both thumbnails for 6 years. Upon her visit to our clinic, she had pigmented onychomycosis with onycholysis in the distal area. There was no evidence of paronychia. Read More

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http://dx.doi.org/10.1111/1346-8138.15024DOI Listing
October 2019
4 Reads

The Modified Upper Lip Lift: Advanced Approach with Deep-Plane Release and Secure Suspension: 823-Patient Series.

Authors:
Benjamin Talei

Facial Plast Surg Clin North Am 2019 Aug 17;27(3):385-398. Epub 2019 May 17.

Facial Plastic & Reconstructive Surgery, Beverly Hills Center for Plastic & Laser Surgery, 465 North Roxbury Drive, Suite 750, Beverly Hills, CA 90210, USA. Electronic address:

The modified upper lip lift procedure is a simple evolution of the cutaneous bullhorn subnasal lip lift. The superficial muscular aponeurotic system layer in the lip is described along with the pyriform ligament, both of which play an essential role in lip lifting. This article details an easily reproducible deep-plane technique that can be applied to patients of all ages, ethnicities, and skin types. Read More

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http://dx.doi.org/10.1016/j.fsc.2019.04.004DOI Listing
August 2019
1 Read

Lichen Planus Pigmentosus: A Clinico-etiological Study.

Indian Dermatol Online J 2019 May-Jun;10(3):288-292

Department of Dermatology and STD, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.

Introduction: Lichen planus pigmentosus (LPP) is a distinct clinical entity commonly encountered in the Indian population.

Aim: To study the clinicoetiological profile of LPP at a tertiary care hospital.

Methods: A total of 100 patients with clinically and histopathologically confirmed diagnosis of LPP were included. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_253_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536068PMC
June 2019
19 Reads

Significant reduction in the expression of interleukins-17A, 22 and 23A, forkhead box p3 and interferon gamma delineates lichen planus pigmentosus from lichen planus.

Arch Dermatol Res 2019 Sep 14;311(7):519-527. Epub 2019 May 14.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, India.

Recent studies have noticed significant role of interleukin (IL)-17, 22, 23, Foxp3, interferon-gamma (IFN-γ) and Wnt5a in oral and cutaneous lichen planus (LP). This study was undertaken to assess whether similar expression exists in lichen planus pigmentosus (LPP). We recruited 30 patients of treatment-naïve 'LPP' (in absence of cutaneous/mucosal LP elsewhere, group 1), 10 patients having active treatment-naïve cutaneous 'LP' (group 2), 10 patients having 'post-LP' hyperpigmentation (in absence of active LP and off treatment for at least past 3 months, group 3), and 10 controls. Read More

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http://dx.doi.org/10.1007/s00403-019-01926-9DOI Listing
September 2019
4 Reads
2.270 Impact Factor

Generating Cyan Fluorescence with De Novo Tripeptides: An In Vitro Mutation Study on the Role of Single Amino Acid Residues and Their Sequence.

Chembiochem 2019 09 29;20(18):2324-2330. Epub 2019 Jul 29.

Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511436, P. R. China.

Amino acids are natural choices as building blocks when developing biofunctional entities owing to their superior diversity and versatile physicochemical properties compared to nucleotide bases. A simple permutation of the amino acids creates a broad palette of proteins and these have been successfully engineered into useful biofunctional agents. For example, the intrinsic ultraviolet fluorescence of phenylalanine and tryptophan has been engineered to emit in the visible spectrum, which has broad applications for imaging/sensing probes, photothermal therapy agents, optogenetic switches, etc. Read More

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http://dx.doi.org/10.1002/cbic.201900166DOI Listing
September 2019
9 Reads

Janus kinase inhibitor tofacitinib does not facilitate the repigmentation in mouse model of rhododendrol-induced vitiligo.

J Dermatol 2019 Jun 10;46(6):548-550. Epub 2019 Apr 10.

Department of Dermatology, Yamagata University School of Medicine, Yamagata, Japan.

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http://dx.doi.org/10.1111/1346-8138.14879DOI Listing
June 2019
4 Reads

Q-switched double-frequency Nd:YAG (532 nm) laser is an effective treatment for racial lip pigmentation.

J Cosmet Dermatol 2019 Dec 9;18(6):1672-1674. Epub 2019 Apr 9.

Department of Dermatology, Imam Muhammad ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.

Introduction: Lip darkening is a relatively common condition, especially in the Middle East and Southeast Asia. It is well documented in the literature and generally considered to be multifactorial. The presentation can be physiologic or pathologic and caused by a variety of local or systemic factors. Read More

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http://dx.doi.org/10.1111/jocd.12946DOI Listing
December 2019
12 Reads

Acne and Rosacea: Special Considerations in the Treatment of Patients With Latin American Ancestry

J Drugs Dermatol 2019 Mar;18(3):s124-126

Acne is a common disease among patients with Latin American ancestry. Its presentation is very similar to that in all skin types, but nodulocystic acne is more frequent in patients with oily and darker skin than in white Caucasians. Acne sequelae in patients with Latin American ancestry and with darker skin include postinflammatory hyperpigmentation (PIH) and atrophic and hypertrophic scars or keloids, with PIH being the most common complication affecting the quality of life of patients. Read More

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March 2019
11 Reads

Disorders of Hypopigmentation

J Drugs Dermatol 2019 Mar;18(3):s115-s116

Hypopigmentation and depigmentation of the skin can be due to multiple causes and has a broad differential diagnosis. The most common cause of depigmentation worldwide is vitiligo. This disorder affects 1-2% of the world’s population and is seen in all races. Read More

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March 2019
8 Reads

[Clinical problems in medical mycology: problem number 53].

Rev Iberoam Micol 2019 Apr - Jun;36(2):93-95. Epub 2019 Mar 9.

Unidad de Micología, Hospital de Infecciosas Francisco Javier Muñiz, Buenos Aires, Argentina.

A 21 year-old man, HIV infected, and with poor adherence to antiretroviral treatment, consulted us due to a papular rash on trunk and extremities, showing simultaneously hypochromic stains on his back. He was afebrile and hemodynamically stable. In the mycological study of the clinical samples taken from different lesions, yeasts compatible with Malassezia were observed. Read More

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http://dx.doi.org/10.1016/j.riam.2019.02.001DOI Listing
February 2020
12 Reads

Melasma: How hormones can modulate skin pigmentation.

J Cosmet Dermatol 2019 Apr 18;18(2):458-463. Epub 2019 Feb 18.

San Gallicano Dermatological Institute (IRCCS), Rome, Italy.

We described-along with a genetic predisposition and exposure to sunlight, as the main factors for melasma development-pregnancy, hormonal therapies, and oral contraceptive pills. Whilst hormonal alteration or therapies are frequently reported in literature in association with melasma, studies analyzing the laboratoristic correlation are limited. We review data published on hormones variations both in women and males with melasma and report some peculiar clinical cases that further demonstrate how the relationship between hormone secretion and melasma development is difficult to be defined. Read More

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http://dx.doi.org/10.1111/jocd.12877DOI Listing
April 2019
46 Reads

[Research progress of dyskeratosis congenita].

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Feb;54(2):130-134

Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Chengdu 610041, China.

Dyskeratosis congenita (DC) is a rare disease and a genetic heterogeneity of bone marrow failure, characterized by muco-cutaneous triad of mucosal leukoplakia, abnormal skin pigmentation, nails dystrophy and often involving multiple organs or systems. The inheritance patterns of DC include X-linked recessive, autosomal dominant and recessive patterns. However, the inheritance patterns in 30%-40% of DC patients remained unknown. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2019.02.010DOI Listing
February 2019
7 Reads

One-year pilot study on the effects of nitisinone on melanin in patients with OCA-1B.

JCI Insight 2019 Jan 24;4(2). Epub 2019 Jan 24.

National Eye Institute and.

Background: Oculocutaneous albinism (OCA) results in reduced melanin synthesis, skin hypopigmentation, increased risk of UV-induced malignancy, and developmental eye abnormalities affecting vision. No treatments exist. We have shown that oral nitisinone increases ocular and fur pigmentation in a mouse model of one form of albinism, OCA-1B, due to hypomorphic mutations in the Tyrosinase gene. Read More

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http://insight.jci.org/articles/view/124387
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http://dx.doi.org/10.1172/jci.insight.124387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413781PMC
January 2019
42 Reads

Black and Brown: Non-neoplastic Pigmentation of the Oral Mucosa.

Head Neck Pathol 2019 Mar 22;13(1):47-55. Epub 2019 Jan 22.

Louisiana State University, 1100 Florida Avenue, New Orleans, LA, 70119, USA.

Black and brown pigmentation of the oral mucosa can occur due to a multitude of non-neoplastic causes. Endogenous or exogenous pigments may be responsible for oral discoloration which can range from innocuous to life-threatening in nature. Physiologic, reactive, and idiopathic melanin production seen in smoker's melanosis, drug-related discolorations, melanotic macule, melanoacanthoma and systemic diseases are presented. Read More

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http://dx.doi.org/10.1007/s12105-018-0980-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405786PMC
March 2019
28 Reads

A case of autonomous cortisol secretion in a patient with subclinical Cushing's syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone.

BMC Endocr Disord 2019 Jan 22;19(1):13. Epub 2019 Jan 22.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Increased urinary free cortisol in response to the oral administration of dexamethasone is a paradoxical reaction mainly reported in patients with primary pigmented nodular adrenocortical disease. Here, we describe the first case of subclinical Cushing's syndrome represented by autonomous cortisol secretion and paradoxical response to oral dexamethasone administration, harboring an activating mutation in the α subunit of the stimulatory G protein (GNAS).

Case Presentation: A 65-year-old woman was diagnosed with subclinical Cushing's syndrome during an evaluation for bilateral adrenal masses. Read More

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http://dx.doi.org/10.1186/s12902-019-0345-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343241PMC
January 2019
16 Reads

Genetic and environmental risk factors for vitiligo and melanoma in Pura Raza Español horses.

Equine Vet J 2019 Sep 1;51(5):606-611. Epub 2019 Feb 1.

Department of Agro-Forestry Sciences, ETSIA, University of Seville, Seville, Spain.

Background: Vitiligo and melanoma are relatively common disorders in grey Pura Raza Español horses and other horse breeds with grey-coloured coats.

Objectives: To determine the breed prevalence, environmental risks factors and estimate the genetic parameters for vitiligo and melanoma in Pura Raza Español horses.

Study Design: Retrospective cohort study. Read More

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http://doi.wiley.com/10.1111/evj.13067
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http://dx.doi.org/10.1111/evj.13067DOI Listing
September 2019
32 Reads

PGN_0297 is an essential component of the type IX secretion system (T9SS) in Porphyromonas gingivalis: Tn-seq analysis for exhaustive identification of T9SS-related genes.

Microbiol Immunol 2019 Jan;63(1):11-20

Department of Microbiology and Oral Infection, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8588, Japan.

The type IX secretion system (T9SS) was originally discovered in Porphyromonas gingivalis, one of the pathogenic bacteria associated with periodontal disease and is now known to be present in many members of the phylum Bacteroidetes. The T9SS secretes a number of potent virulence factors, including the highly hydrolytic proteases called gingipains, across the outer membrane in P. gingivalis. Read More

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http://dx.doi.org/10.1111/1348-0421.12665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590471PMC
January 2019
6 Reads

Dyskeratosis congenita: presentation of cutaneous triad in a sporadic case.

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Department of Surgery, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Dyskeratosis congenita (DKC) also known as Zinsser-Cole-Engman syndrome is a progressive genetic disease with a classical presentation characterised by a triad of reticulate pigmentation of skin, nail dystrophy and leukoplakia. It may be a multisystem disease with the involvement of haematological, gastrointestinal, genitourinary, neurological, ophthalmic, pulmonary and skeletal system. We report a sporadic case of DKC presenting with poikiloderma, nail dystrophy and oral leukoplakia. Read More

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http://dx.doi.org/10.1136/bcr-2018-226736DOI Listing
November 2018
10 Reads

General hyperpigmentation induced by Grave's disease: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13279

Department of Endocrinology, The Second Affiliated Hospital of Zhejiang University School of Medicine.

Rationale: Hyperpigmentation is a common skin disease. However, there are few reported cases of Grave's disease with diffuse hyperpigmentation. We hereby described a rare case with diffuse hyperpigmentation induced by Grave's disease. Read More

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http://dx.doi.org/10.1097/MD.0000000000013279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310574PMC
December 2018
10 Reads

Oral tranexamic acid for the treatment of melasma.

Authors:
F R Ali

Clin Exp Dermatol 2019 Apr 28;44(3):347-349. Epub 2018 Nov 28.

Dermatological Surgery and Laser Unit, Guy's Cancer Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1111/ced.13831DOI Listing
April 2019
14 Reads

Craniofacial skeleton of MEXICAN tetra (Astyanax mexicanus): As a bone disease model.

Dev Dyn 2019 02 18;248(2):153-161. Epub 2018 Dec 18.

Department of Oral Biology, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

A small fresh water fish, the Mexican tetra (Astyanax mexicanus) is a novel animal model in evolutionary developmental biology. The existence of morphologically distinct surface and cave morphs of this species allows simultaneous comparative analysis of phenotypic changes at different life stages. The cavefish harbors many favorable constructive traits (i. Read More

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http://doi.wiley.com/10.1002/dvdy.4
Publisher Site
http://dx.doi.org/10.1002/dvdy.4DOI Listing
February 2019
19 Reads

Sub-lethal effects induced by a mixture of different pharmaceutical drugs in predicted environmentally relevant concentrations on Lithobates catesbeianus (Shaw, 1802) (Anura, ranidae) tadpoles.

Environ Sci Pollut Res Int 2019 Jan 8;26(1):600-616. Epub 2018 Nov 8.

Post-Graduation Program in Conservation of Cerrado Natural Resources - Biological Research Laboratory, Goiano Federal Institute-Urutaí Campus, Urutaí, GO, Brazil.

The increasing consumption of medications by humans has negative effects such as the increased disposal of these compounds in the environment. Little is known about how the disposal of a "drug mix" (DM) in aquatic ecosystems can affect their biota. Thus, we evaluated whether the exposure of Lithobates casteibeianus tadpoles to a DM composed of different medication classes (antibiotic, anti-inflammatory, antidepressant, anxiolytic, analgesic, and antacid drugs)-at environmentally relevant concentrations-may change their oral morphology, trigger behavioral disorders, and have mutagenic effects on erythrocyte cells. Read More

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http://link.springer.com/10.1007/s11356-018-3656-9
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http://dx.doi.org/10.1007/s11356-018-3656-9DOI Listing
January 2019
32 Reads

Minimal Efficacy of Nitisinone Treatment in a Novel Mouse Model of Oculocutaneous Albinism, Type 3.

Invest Ophthalmol Vis Sci 2018 10;59(12):4945-4952

Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States.

Purpose: Oral nitisinone has been shown to increase fur and ocular pigmentation in a mouse model of oculocutaneous albinism (OCA) due to hypomorphic mutations in tyrosinase (TYR), OCA1B. This study determines if nitisinone can improve ocular and/or fur pigmentation in a mouse model of OCA type 3 (OCA3), caused by mutation of the tyrosinase-related protein 1 (Tyrp1) gene.

Methods: Mice homozygous for a null allele in the Tyrp1 gene (C57BL/6J-Tyrp1 b-J/J) were treated with 8 mg/kg nitisinone or vehicle every other day by oral gavage. Read More

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http://dx.doi.org/10.1167/iovs.16-20293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181301PMC
October 2018
22 Reads

Black esophagus: a case report.

Tunis Med 2018 Feb;96(2):142-147

Introduction: Acute esophageal necrosis, also known as black esophagus, is a rare digestive complication, frequently manifested by an upper gastrointestinal hemorrhage and occurs in patients with comorbidities.

Aim: To report the case of a patient with a black esophagus revealed by an upper gastrointestinal hemorrhage.

Observation: A 72-year-old patient with a history of diabetes mellitus, hypertension and ischemic heart disease was hospitalized in surgical intensive care unit for hemorrhagic shock induced by cholecystectomy. Read More

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February 2018
44 Reads

Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier-Hunziker syndrome.

World J Clin Cases 2018 Sep;6(10):322-334

Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, Jiangsu Province, China.

Labial and oral melanotic macules are commonly encountered in a broad range of conditions ranging from physiologic pigmentation to a sign of an underlying life-threatening disease. Although Laugier-Hunziker syndrome (LHS) shares some features of labial and oral pigmentation with a variety of conditions, it is a benign and acquired condition, frequently associated with longitudinal melanonychia. Herein, the demographic, clinical, dermoscopic, and pathological aspects of LHS were reviewed comprehensively. Read More

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http://dx.doi.org/10.12998/wjcc.v6.i10.322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163135PMC
September 2018
18 Reads

Congenital laryngeal paralysis in Alaskan Huskies: 25 cases (2009-2014).

J Am Vet Med Assoc 2018 Oct;253(8):1057-1065

OBJECTIVE To characterize congenital laryngeal paralysis (CLP) in Alaskan Huskies. DESIGN Prospective case series. ANIMALS 25 Alaskan Huskies with CLP. Read More

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https://avmajournals.avma.org/doi/10.2460/javma.253.8.1057
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http://dx.doi.org/10.2460/javma.253.8.1057DOI Listing
October 2018
15 Reads

New technical method to correct secondary vermilion deformities with cleft lip.

J Plast Reconstr Aesthet Surg 2018 Dec 8;71(12):1810-1815. Epub 2018 Aug 8.

Department of Plastic and Reconstructive Surgery, Sapporo Medical University School of Medicine, S1W16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan.

Various techniques for correcting whistling deformities that occurred after primary surgery for cleft lip have been reported. These techniques are mainly intended to correct the lack of volume of the red lip. However, irregularity of the dry-wet lip junction (mucocutaneous junction) in the red lip has rarely been mentioned. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17486815183026
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http://dx.doi.org/10.1016/j.bjps.2018.07.025DOI Listing
December 2018
31 Reads

Frequency of Pathologic Changes in the Oral Cavity in Patients Subjected to Long-term Pharmacologic Immunosuppressive Therapy After Kidney, Liver, and Hematopoietic Cell Transplantation.

Transplant Proc 2018 Sep 11;50(7):2176-2178. Epub 2018 Apr 11.

Department of General and Transplantation Surgery, Medical University of Warsaw, Warsaw, Poland.

Introduction: Patients subjected to long-term immunosuppressive therapy after organ and cells transplantation are more susceptible than healthy people to the development of the pathologic changes in the oral cavity, including precancerous lesions, oral cancers, lesions following viral infections (herpes simplex virus, Epstein-Barr virus, and cytomegalovirus), fungal infections mainly caused by Candida albicans, drug-induced gingival overgrowth, stomatitis, and tongue disorders.

Material And Methods: Clinical case material included 38 patients after kidney, liver, or blood-forming cells transplantation subjected to various immunosuppressive therapy schemes. The study comprised standard case taking and physical examination of the patient, including detailed intraoral and extraoral stomatological examinations. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.003DOI Listing
September 2018
39 Reads

The role of systemic treatments for skin lightening.

J Cosmet Dermatol 2018 Dec 21;17(6):1144-1157. Epub 2018 Aug 21.

The Ronald O. Perelman Department of Dermatology, New York University Langone Health, New York City, New York.

Background: Pigmentation of the skin occurs as a result of increased melanin production or deposition due to various reasons including age, hormonal imbalances, endocrine disease, inflammation, and/or exposure to damaging radiation, resulting in dermatologic conditions such as lentigines, melasma, or postinflammatory hyperpigmentation. Although numerous topical therapies exist for skin lightening, they are limited by efficacy and pigmentation recurrence after treatment cessation. New research into systemic therapies for hyperpigmentation has been promising. Read More

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http://doi.wiley.com/10.1111/jocd.12747
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http://dx.doi.org/10.1111/jocd.12747DOI Listing
December 2018
39 Reads

An outbreak of Coxsackievirus A6-associated hand, foot, and mouth disease in a kindergarten in Beijing in 2015.

BMC Pediatr 2018 08 21;18(1):277. Epub 2018 Aug 21.

Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, No. 10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing, 100069, People's Republic of China.

Background: Coxsackievirus A6 (CVA6) is one of the major agents to cause hand, foot and mouth disease (HFMD) outbreaks globally. The objective of this study is to investigate the epidemiologic and clinical manifestations of CVA6 outbreak, and thus guide the diagnosis and treatment of the disease, as well as disease prevention.

Methods: An HFMD outbreak in a kindergarten was reported to Shijingshan District Center for Disease Control and Prevention (SCDC) on November 2, 2015 in Beijing, China. Read More

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http://dx.doi.org/10.1186/s12887-018-1253-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103857PMC
August 2018
43 Reads
1.920 Impact Factor

Pigmented (melanotic) diffuse neurofibroma of the back in neurofibromatosis type 1.

GMS Interdiscip Plast Reconstr Surg DGPW 2018 3;7:Doc04. Epub 2018 Aug 3.

Institute of Neuropathology, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany.

Neurofibromatosis type 1 (NF1) is a tumor predisposition disease. Multiple neurofibromas are among the characteristic tumors of NF1. The report describes the diagnosis and treatment of a large spinal neurofibroma in a NF1 patient. Read More

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http://dx.doi.org/10.3205/iprs000124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073164PMC
August 2018
17 Reads