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    1090 results match your criteria Disorders of Oral Pigmentation

    1 OF 22

    The Role of Diet and Supplements in Vitiligo Management.
    Dermatol Clin 2017 Apr;35(2):235-243
    Vitiligo & Pigmentation Institute of Southern California, 5670 Wilshire Boulevard, #650, Los Angeles, CA 90036, USA.
    Vitiligo is an autoimmune disorder that involves the interplay between oxidative stress and the immune system. Preliminary observations suggest that the presence of gluten in the diet may play a role in vitiligo development in some patients, but to date vitiligo-specific diets have not been studied. The role of oral supplements, including vitamins, minerals, and botanicals, is increasingly being investigated as adjuncts to conventional medical treatment due to their antioxidant and immunomodulatory activity. Read More

    African ancestry is associated with facial melasma in women: a cross-sectional study.
    BMC Med Genet 2017 Feb 17;18(1):17. Epub 2017 Feb 17.
    Department of Dermatology, FMB-Unesp, Botucatu, SP, Brazil.
    Background: Melasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in different populations. Read More

    Common Skin Conditions in Children: Noninfectious Rashes.
    FP Essent 2017 Feb;453:18-25
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

    Pharmacokinetics and Pharmacodynamics of Afamelanotide and its Clinical Use in Treating Dermatologic Disorders.
    Clin Pharmacokinet 2017 Jan 6. Epub 2017 Jan 6.
    Stadtspital Triemli, Institute of Laboratory Medicine, Zurich, Switzerland.
    Afamelanotide, the first α-melanocyte-stimulating hormone (MSH) analogue, synthesized in 1980, was broadly investigated in all aspects of pigmentation because its activity and stability were higher than the natural hormone. Afamelanotide binds to the melanocortin-1 receptor (MC1R), and MC1R signaling increases melanin synthesis, induces antioxidant activities, enhances DNA repair processes and modulates inflammation. The loss-of-function variants of the MC1R present in fair-skinned Caucasians are less effectively activated by the natural hormone. Read More

    Trauma due to Self-aggression in Patient with Waardenburg Syndrome associated with Congenital Anomalies.
    J Contemp Dent Pract 2016 Aug 1;17(8):702-5. Epub 2016 Aug 1.
    Department of Dentistry, Universidade do Sagrado Coração, São Paulo, Brazil.
    Waardenburg syndrome (WS) is an inherited autosomal dominant genetic disorder presenting variable penetrance and expressivity, with an estimated prevalence of 1:42,000. Clinical characteristics of WS include lateral displacement of the internal eye canthus, hyperplasia of the medial portion of the eyebrows, prominent and broad nasal base, congenital deafness, pigmentation of the iris and skin, and white forelock. A 24-year-old male patient, previously diagnosed with WS, was referred to the Special Needs Dental Clinic of Sacred Heart University, Bauru, Brazil. Read More

    Salt and Pepper Pigmentation - Skin Manifestation of Systemic Sclerosis.
    J Assoc Physicians India 2015 Sep;63(9):70
    Postgraduate Student, Dept. of General Medicine, Govt. Mohan Kumaramangalam Medical College and Hospital, Salem, Tamil Nadu.
    A 50 year old male presented with progressive difficulty in swallowing both liquid and solid food with no history of Raynaud's phenomenon. A general examination revealed skin changes in the form of thickening, hyperpigmentation and tightening of skin of fingers, hand, forearm and legs. The patient had painless skin induration over the legs, forearm and hand. Read More

    Dyskeratosis congenita presenting with dysphagia.
    Indian Dermatol Online J 2016 Jul-Aug;7(4):275-7
    Department of Dermatology, Venereology and Leprosy, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.
    Dyskeratosiscongenita (DKC) is a genetically heterogeneous disease of defective telomere maintenance that may demonstrate different patterns of inheritance. It is characterized by thetriad of dystrophy of the nails, leukokeratosis of the oral mucosa, and extensive net-like pigmentation of the skin. We report a case ofDKC who presented with a chief complaint of dysphagia. Read More

    Prurigo Pigmentosa-Report of 3 Cases From Brazil and Literature Review.
    Am J Dermatopathol 2017 Apr;39(4):267-274
    *Departments of Dermatology and Pathology, Hospital Federal de Bonsucesso, Rio de Janeiro, Brazil; †Department of Dermatology, Hospital Federal de Bonsucesso, Rio de Janeiro, Brazil; ‡Department of Dermatology, Hospital Universitário Gafrée e Guinle, Rio de Janeiro, Brazil; §Detartment of Dermatology, Hospital Federal Servidores do Estado, Rio de Janeiro, Brazil; and ¶ID-Investigação em Dermatologia, dermatopathology consultive services, Rio de Janeiro, Brazil.
    Prurigo pigmentosa (PP) is a rare inflammatory disease of the skin of uncertain etiology first reported in Japan. It is typified by recurrent eruptions of itching urticarial macules, papules, vesicopapules, and plaques with a reticular arrangement that quickly resolve leaving a net-like pigmentation. The disease presents specific histopathological features. Read More

    The role of systemic steroids and phototherapy in the treatment of stable vitiligo: a randomized controlled trial.
    Dermatol Ther 2016 Nov 16;29(6):406-412. Epub 2016 Aug 16.
    Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
    Pathogenesis of vitiligo is believed to be multifactorial disease with a wide variety of therapeutic modalities. The aim of this work is to assess the efficacy of oral mini-pulse steroids (OMP) plus Nb-U.V. Read More

    Condylomata lata on the ankle: an unusual location.
    Dermatol Pract Concept 2016 Apr 30;6(2):49-51. Epub 2016 Apr 30.
    Department of Dermatology, Tokyo Woman's Medical University Medical Center East, Tokyo, Japan.
    A 43-year-old Japanese man presented with reddish nodules on the ankle. The nodules had a yellowish crust and eroded surface. Dermoscopy revealed red to milky-red globules at the periphery and some glomerular vessels in the center and a whitish-pink network, which corresponded to capillary dilatation in the papillary dermis and prominent acanthosis, respectively. Read More

    DYSKERATOSIS CONGENITA IN TWO ETHIOPIAN BROTHERS.
    Ethiop Med J 2015 Oct;53(4):215-21
    Dyskeratosis congenita (DKC) is a rare, progressive bone marrow failure syndrome that is characterized by the triad of reticulated skin pigmentation, nail dystrophy and oral leukoplakia. Current evidence indicates that DKC is a disease of defective telomere maintenance, ribosome deficiency and protein synthesis dysfunction. Mortality is often associated with bone marrow failure (BMF), development of malignancy and other multisystem complications of the disease. Read More

    Multiple osteoblastomas in a child with Cushing syndrome due to bilateral adrenal micronodular hyperplasias.
    Ann Pediatr Endocrinol Metab 2016 Mar 31;21(1):47-50. Epub 2016 Mar 31.
    Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
    Adrenocorticotropin-independent adrenal hyperplasias are rare diseases, which are classified into macronodular (>1 cm) and micronodular (≤1 cm) hyperplasia. Micronodular adrenal hyperplasia is subdivided into primary pigmented adrenocortical disease and a limited or nonpigmented form 'micronodular adrenocortical disease (MAD)', although considerable morphological and genetic overlap is observed between the 2 groups. We present an unusual case of a 44-month-old girl who was diagnosed with Cushing syndrome due to MAD. Read More

    Glutathione as a skin whitening agent: Facts, myths, evidence and controversies.
    Indian J Dermatol Venereol Leprol 2016 May-Jun;82(3):262-72
    Skinnocence: The Skin Clinic, Gurgaon, Haryana, India.
    Glutathione is a low molecular weight thiol-tripeptide that plays a prominent role in maintaining intracellular redox balance. In addition to its remarkable antioxidant properties, the discovery of its antimelanogenic properties has led to its promotion as a skin-lightening agent. It is widely used for this indication in some ethnic populations. Read More

    Low-dose oral isotretinoin therapy in lichen planus pigmentosus: an open-label non-randomized prospective pilot study.
    Int J Dermatol 2016 Sep 7;55(9):1048-54. Epub 2016 Apr 7.
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: Lichen planus pigmentosus (LPP) is a cosmetically distressing pigmentary disorder often posing a therapeutic challenge. Isotretinoin has been shown to be effective in oral and cutaneous LP, but its role in LPP is yet unknown.

    Objective: To evaluate the efficacy and safety of isotretinoin in the management of LPP. Read More

    HIV-Associated Oral Mucosal Melanin Hyperpigmentation: A Clinical Study in a South African Population Sample.
    AIDS Res Treat 2016 24;2016:8389214. Epub 2016 Feb 24.
    Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
    Objective. The aim of the study was to determine the prevalence of HIV-associated oral mucosal melanin hyperpigmentation (HIV-OMH) in a specific population of HIV-seropositive South Africans and to analyse the associations between HIV-OMH clinical features and the demographic and immunological characteristics of the study cohort. Material and Methods. Read More

    Erythrosis Pigmentosa Peribuccalis in an Adolescent: Dermoscopic Description and Management.
    Pediatr Dermatol 2016 Mar-Apr;33(2):e65-8. Epub 2016 Jan 29.
    Hospital Alemán, Buenos Aires, Argentina.
    Erythrosis pigmentosa peribuccalis is an infrequent condition, with fewer than 35 cases reported in the literature, that affects mainly women. It presents as small papules that form a hyperpigmented plaque around the mouth and nose. Little is known about the etiology of this condition, its dermoscopic characteristics have not been described, and no effective treatment has been reported. Read More

    Dyskeratosis congenita associated with leukoplakia of the tongue.
    Int J Oral Maxillofac Surg 2016 Jun 5;45(6):760-3. Epub 2016 Jan 5.
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan.
    Dyskeratosis congenita (DC) is an inherited disease characterized by the triad of skin pigmentation, nail dystrophy, and oral leukoplakia. Among other abnormalities, bone marrow failure and a predisposition to cancer are recognized as the major causes of premature mortality in patients with DC. This disease is associated with short telomeres and mutations in 10 genes associated with telomerase and telomere components. Read More

    The role of STK 11 gene testing in individuals with oral pigmentation.
    Australas J Dermatol 2016 Jan 14. Epub 2016 Jan 14.
    Royal Melbourne Hospital, Familial Cancer Centre, Melbourne, Victoria, Australia.
    Peutz-Jeghers syndrome (PJS) is a rare, autosomal dominant condition characterised by mucocutaneous pigmented lesions, gastrointestinal polyposis and a significant risk of cancer. Laugier-Hunziker syndrome (LHS) is a benign condition with similar dermatological features, but with no systemic complications. STK 11 gene testing allows clinicians to differentiate between these two disorders. Read More

    [Pathogenic and clinical presentation of bullous rash in hand, foot and mouth disease].
    Zhonghua Er Ke Za Zhi 2015 Aug;53(8):616-20
    Objective: To investigate the pathogenic and clinical presentation and laboratory tests of bullous rash in hand, foot and mouth disease (HFMD) in Xi'an from January 2013 to December 2014 by retrospective analysis.

    Method: A total of 224 specimens were collected from clinically diagnosed HFMD cases who were characterized by widespread mucocutaneous bullous reactions in Xi'an Children's Hospital from January 2013 to December 2014, the identification and subtyping of the isolates were conducted with real-time fluorescent quantitative RT-PCR. A retrospective analysis was performed to analyze the clinical presentation, laboratory tests and late follow-up problems of the HFMD. Read More

    Prevalence and clinical features of pigmented oral lesions.
    Int J Dermatol 2016 Sep 28;55(9):1005-13. Epub 2015 Dec 28.
    University College London, London, UK.
    Background: To examine the relative prevalence, types, and clinical features of pigmented lesions of the oral mucosa in 1275 patients attending a university hospital for dental care.

    Methods: Patients attending dental clinics at The University of Jordan Hospital over a 1-year period were examined for the presence of oral pigmentations. Histopathological examination was performed on focally pigmented lesions with a suspicious or uncertain clinical diagnosis. Read More

    Removal of black stains from teeth by photodynamic therapy: clinical and microbiological analysis.
    BMJ Case Rep 2015 Dec 23;2015. Epub 2015 Dec 23.
    Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
    Black-pigmented bacteria (BPB) are Gram-negative anaerobic, non-motile, proteolytic rods strongly implicated in the pathogenesis of periodontal disease. Although pigments are produced in vitro, black pigmentation is rarely found clinically. However, it may compromise aesthetics and contribute to gingival inflammation. Read More

    Safety of administering the canine melanoma DNA vaccine (Oncept) to cats with malignant melanoma - a retrospective study.
    J Feline Med Surg 2017 Feb 10;19(2):224-230. Epub 2016 Jul 10.
    3 VCA Clinical Studies, Bedford Hills, NY, USA.
    Objectives A xenogeneic human tyrosinase DNA vaccine was developed for treatment of dogs with oral malignant melanoma (Oncept; Merial). No studies have evaluated the safety or efficacy of this vaccine in cats. The purpose of this study was to evaluate the safety of the canine melanoma vaccine in cats diagnosed with melanoma. Read More

    The Smile Esthetic Index (SEI): A method to measure the esthetics of the smile. An intra-rater and inter-rater agreement study.
    Eur J Oral Implantol 2015 ;8(4):397-403
    Purpose: To propose a method to measure the esthetics of the smile and to report its validation by means of an intra-rater and inter-rater agreement analysis.

    Materials And Methods: Ten variables were chosen as determinants for the esthetics of a smile: smile line and facial midline, tooth alignment, tooth deformity, tooth dischromy, gingival dischromy, gingival recession, gingival excess, gingival scars and diastema/missing papillae. One examiner consecutively selected seventy smile pictures, which were in the frontal view. Read More

    Graphite oral tattoo: case report.
    Dermatol Online J 2015 Oct 16;21(10). Epub 2015 Oct 16.
    Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, Univ. Estadual Paulista-UNESP, São José dos Campos, São Paulo, Brazil.
    Pigmented oral lesions compose a large number of pathological entities, including exogenous pigmentat oral tattoos, such as amalgam and graphite tattoos. We report a rare case of a graphite tattoo on the palate of a 62-year-old patient with a history of pencil injury, compare it with amalgam tattoos, and determine the prevalence of oral tattoos in our Oral Pathology Service. We also compare the clinical and histological findings of grafite and amalgam tattoos. Read More

    Pharyngeal Presentation of Goltz Syndrome: A Case Report with Review of the Literature.
    Head Neck Pathol 2016 Jun 17;10(2):188-91. Epub 2015 Nov 17.
    Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, The Pennsylvania State University, College of Medicine, 500 University Drive, H091, Hershey, PA, 17033-0850, USA.
    Focal dermal hypoplasia (Goltz syndrome; GS) is an X-linked dominant disorder caused by a mutation in the porcupine homolog (PORCN) gene and is typically embryonically lethal for males. The presence of disease in males is usually the result of post-zygotic mutation, but may also be due to mosaicism. The presentation of this disorder is highly variable, but generally is characterized by cutaneous, skeletal, ocular, oral, dental, and aural defects. Read More

    Odontoiatric perspectives and osteonecrosis of the jaw as a possible adverse effect of bisphosphonates therapy in fibrous dysplasia and McCune-Albright syndrome.
    J Pediatr Endocrinol Metab 2016 Mar;29(3):333-6
    Background: McCune-Albright syndrome (MAS) is characterized by the triad of polyostotic bone fibrous dysplasia (PFD), endocrine disorders, and café-au-lait skin pigmentation. Ninety percent of MAS patients have fibrous dysplasia (FD) craniofacial lesions. Osteonecrosis of the jaw (ONJ) has been described as an adverse side effect of bisphosphonate therapy. Read More

    Macular pigmentation complicating irritant contact dermatitis and viral warts in Laugier-Hunziker syndrome.
    Clin Exp Dermatol 2016 Apr 28;41(3):294-6. Epub 2015 Oct 28.
    Department of Dermatology, Singleton Hospital, Swansea, UK.
    Laugier-Hunziker syndrome (LHS) is a rare acquired disorder characterized by macu-lar pigmentation of the lips and oral mucosa, with frequent longitudinal melanonychia. Involvement of other areas, such as the genitalia and fingers, has rarely been described. LHS is a benign condition with no known systemic manifestations. Read More

    Heimler Syndrome Is Caused by Hypomorphic Mutations in the Peroxisome-Biogenesis Genes PEX1 and PEX6.
    Am J Hum Genet 2015 Oct 17;97(4):535-45. Epub 2015 Sep 17.
    Department of Medical Genetics, University of Antwerp, Antwerp 2610, Belgium. Electronic address:
    Heimler syndrome (HS) is a rare recessive disorder characterized by sensorineural hearing loss (SNHL), amelogenesis imperfecta, nail abnormalities, and occasional or late-onset retinal pigmentation. We ascertained eight families affected by HS and, by using a whole-exome sequencing approach, identified biallelic mutations in PEX1 or PEX6 in six of them. Loss-of-function mutations in both genes are known causes of a spectrum of autosomal-recessive peroxisome-biogenesis disorders (PBDs), including Zellweger syndrome. Read More

    A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice.
    Mol Neurodegener 2015 Sep 3;10:44. Epub 2015 Sep 3.
    Neuroscience, Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland.
    Background: Alzheimer's disease (AD) is the most common form of dementia, the number of affected individuals is rising, with significant impacts for healthcare systems. Current symptomatic treatments delay, but do not halt, disease progression. Genetic evidence points to aggregation and deposition of amyloid-β (Aβ) in the brain being causal for the neurodegeneration and dementia typical of AD. Read More

    Pigmented fungiform papillae of the tongue (PFPT).
    Acta Clin Belg 2016 Apr 8;71(2):117-8. Epub 2016 Feb 8.
    c Department of Neonatology , ZNA Middelheim , Antwerp , Belgium.
    A 12-year-old African girl presented with multiple, sharply bordered hyperpigmented patches predominantly on the dorsal, tip and lateral aspects of the tongue since 1 year (Figs 1 and 2). On clinical examination, we found an obese adolescent girl with a BMI: 26.5 kg/m(2) ( > P97) with acanthosis nigricans of the neck. Read More

    Onychomadesis with Lichen Planus: An Under-Recognized Manifestation.
    Indian J Dermatol 2015 Jul-Aug;60(4):420
    Department of Dermatology, University College of Medical Sciences and GTB Hospital, Dilshad Garden, New Delhi, India.
    Onychomadesis or proximal separation of the nail pate usually results from severe, generalized dermatoses like bullous diseases, hand foot and mouth disease, varicella or severe cutaneous drug reactions. Although lichen planus (LP) produces varied nail manifestations (longitudinal onychorrhexis, onychoschizia, nail pigmentation, pterygium etc.), to the best of our knowledge, onychomadesis as a manifestation of nail LP is not recorded. Read More

    Dyschromatosis Universalis Hereditaria with Oral Leukokeratosis--A Case of Mistaken Identity and Review of the Literature.
    Pediatr Dermatol 2015 Nov-Dec;32(6):e283-7. Epub 2015 Aug 13.
    Department of Dermatology, San Antonio Military Medical Center, Fort Sam Houston, Texas.
    Dyschromatosis universalis hereditaria (DUH) is a rare pigmentary genodermatosis characterized by reticulated hyper- and hypopigmented macules distributed over the trunk and extremities in otherwise healthy patients. DUH presents in a fashion similar to that of a variety of reticulate and pigmentary dermatoses, some of which are associated with precancerous entities and other comorbidities. It is therefore imperative that the clinician recognize and differentiate these disorders so that appropriate screening and counseling can be offered to the patient. Read More

    The wide-ranging clinical implications of the short telomere syndromes.
    Intern Med J 2016 Apr;46(4):393-403
    Children's Medical Research Institute, The University of Sydney, Sydney, New South Wales, Australia.
    There is an increasing number of inherited disorders in which excessive telomere shortening underlies the molecular defect, with dyskeratosis congenita (DC) being the archetypal short telomere syndrome. DC is classically described as a mucocutaneous triad of oral leukoplakia, nail dystrophy and abnormal skin pigmentation. However, excessive telomere shortening can affect almost any organ system, so the clinical manifestations are protean, including developmental delay, cerebellar hypoplasia, exudative retinopathy, aplastic anaemia, acute myeloid leukaemia, idiopathic pulmonary fibrosis, idiopathic hepatic cirrhosis, head and neck cancer and dental abnormalities, and may be multi-systemic. Read More

    Comparison of therapeutic effects of liposomal Tranexamic Acid and conventional Hydroquinone on melasma.
    J Cosmet Dermatol 2015 Sep 14;14(3):174-7. Epub 2015 Jul 14.
    Cutaneous Leishmaniasis Research Center, Department of Dermatology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
    Background: Melasma is one of the most common cosmetic disorders with skin darkening. Although several treatment modalities are available, none is satisfactorily used in management of this condition. Tranexamic acid (TA), a plasmin inhibitor, is reported to improve melasma when injected locally or used as oral and topical forms. Read More

    Dyskeratosis Congenita Without Oral Involvement: A Rare Hereditary Disease.
    Oman Med J 2015 May;30(3):212-5
    Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
    Dyskeratosis congenita (DC) is a rare, progressive, multi-system, inherited disorder of telomere biology, first described in 1906 as the Zinsser-Engman-Cole syndrome. The condition presents with the classic triad of nail dystrophy, reticulate skin pigmentation, and oral leukoplakia. Variable somatic abnormalities may be present; these include pulmonary, gastrointestinal, genitourinary, cerebral, and dental complications. Read More

    Compromised breast flap treated with leech therapy, hyperbaric oxygen, pentoxifylline and topical nitroglycerin: A case report.
    Undersea Hyperb Med 2015 May-Jun;42(3):281-4
    Introduction: Hyperbaric oxygen (HBO2) is often indicated in compromised surgical flaps. Although limited to animal models and human case reports, the utilization of leech therapy (Hirudo medicinalis) with HBO2 provides better outcomes than each modality alone. Topical nitroglycerin and pentoxifylline are also frequently used adjunctively for compromised flaps. Read More

    High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africans.
    Proc Natl Acad Sci U S A 2015 Jun 15;112(26):8052-7. Epub 2015 Jun 15.
    Department of Anthropology, The Pennsylvania State University, University Park, PA 16802; Stellenbosch Institute for Advanced Studies, Stellenbosch 7600, South Africa;
    Cape Town, South Africa, has a seasonal pattern of UVB radiation and a predominantly dark-skinned urban population who suffer high HIV-1 prevalence. This coexistent environmental and phenotypic scenario puts residents at risk for vitamin D deficiency, which may potentiate HIV-1 disease progression. We conducted a longitudinal study in two ethnically distinct groups of healthy young adults in Cape Town, supplemented with vitamin D3 in winter, to determine whether vitamin D status modifies the response to HIV-1 infection and to identify the major determinants of vitamin D status (UVB exposure, diet, pigmentation, and genetics). Read More

    Tyrosol Suppresses Allergic Inflammation by Inhibiting the Activation of Phosphoinositide 3-Kinase in Mast Cells.
    PLoS One 2015 11;10(6):e0129829. Epub 2015 Jun 11.
    Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea.
    Allergic diseases such as atopic dermatitis, rhinitis, asthma, and anaphylaxis are attractive research areas. Tyrosol (2-(4-hydroxyphenyl)ethanol) is a polyphenolic compound with diverse biological activities. In this study, we investigated whether tyrosol has anti-allergic inflammatory effects. Read More

    Anetoderma in a patient with terminal osseous dysplasia with pigmentary defects.
    Am J Med Genet A 2015 Oct 8;167A(10):2459-62. Epub 2015 Jun 8.
    Department of Dermatology, University of Iowa Hospitals and Clinics.
    Terminal osseous dysplasia with pigmentary defects (TODPD) is a rare, X-linked syndrome classically characterized by distal limb anomalies, pigmented skin defects of the face, and recurrent digital fibromas. X-inactivation plays a major role in determining the range of phenotypic expression. Thus, patients can demonstrate a wide spectrum of disease severity, making accurate diagnosis more challenging. Read More

    Localized thermal tumor destruction using dye-enhanced photothermal tumor therapy.
    Lasers Surg Med 2015 Jul 5;47(5):452-61. Epub 2015 Jun 5.
    Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    Background And Objective: In an attempt to develop a new therapeutic approach for highly localized thermal destruction of tissue targets that lack natural pigmentation, the potential of in-vivo dye-enhanced photothermal therapy (PTT) was investigated. PTT involves the application of an exogenous absorber, which accumulates in metabolically active tissues, followed by non-invasive light irradiation, using appropriate wavelengths, exposure durations, and irradiances. The chromophore used, palladium(II) octabutoxynaphthalocyanine (PdNc(OBu)8 ), strongly absorbs in the near infrared wavelength range which thus permits good penetration depth of the exciting light. Read More

    Simultaneous Determination of 11 Illicit Phenethylamines in Hair by LC-MS-MS: In Vivo Application.
    J Anal Toxicol 2015 Sep 29;39(7):532-7. Epub 2015 May 29.
    Dipartimento di Chimica e Farmacia, Università di Sassari, Via Muroni 23/a, 07100 Sassari, Italy.
    Existing phenethylamines are a class of synthetic compounds that differ from each other only in small changes to a largely conserved chemical structure. The recreational and illicit use of phenethylamines is a widespread problem. A simple procedure for the simultaneous quantitative determination in hair of 11 phenethylamines that are officially recognized as illicit by Italian legislation (p-methoxyamphetamine; p-methoxymethamphetamine; 3,4,5-trimethoxyamphetamine; 2,5-dimethoxyamphetamine; 2,5-dimethoxy-4-methylamphetamine; 2,5-dimethoxy-4-ethylamphetamine; 2,5-dimethoxy-4-bromoamphetamine; 2,5-dimethoxy-4-bromophenethylamine; 2,5-dimethoxy-4-iodophenethylamine; 2,5-dimethoxy-4-ethylthiophenethylamine and 2,5-dimethoxy-4-n-propylthiophenethylamine) has been developed and validated. Read More

    Oral mucosal disease in an Australian urban Indigenous community using autofluorescence imaging and reflectance spectroscopy.
    Aust Dent J 2015 Jun 20;60(2):216-24. Epub 2015 May 20.
    UQ Centre for Clinical Research, The University of Queensland, Herston, Queensland.
    Background: The aim of this study was to document the oral mucosal burden in an urban Indigenous community and to evaluate the efficacy of an adjunctive optical device (Identafi(™) ) in a general dental practice.

    Methods: Three hundred and forty-two patients who presented to an urban Aboriginal and Torres Strait Islander Community Health Service (ATSICHS) were examined using conventional oral examination (COE) and with a multispectral device (Identafi(™) ). Loss of autofluorescence (LAF) and the visibility of diffuse vasculature were noted. Read More

    Inhibitory effect of 1,2,4,5-tetramethoxybenzene on mast cell-mediated allergic inflammation through suppression of IκB kinase complex.
    Toxicol Appl Pharmacol 2015 Sep 14;287(2):119-27. Epub 2015 May 14.
    Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 700-422, Republic of Korea. Electronic address:
    As the importance of allergic disorders such as atopic dermatitis and allergic asthma, research on potential drug candidates becomes more necessary. Mast cells play an important role as initiators of allergic responses through the release of histamine; therefore, they should be the target of pharmaceutical development for the management of allergic inflammation. In our previous study, anti-allergic effect of extracts of Amomum xanthioides was demonstrated. Read More

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