1,167 results match your criteria Disorders of Oral Pigmentation


Construct Cyan Fluorescence by De Novo Tripeptides: An In Vitro Mutation Study on the Role of Single Amino Acid Residues and Their Sequence.

Chembiochem 2019 Apr 23. Epub 2019 Apr 23.

Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, P. R. China., Yuexiu Road, CHINA.

Amino acids are a natural choice as building blocks for developing bio-functional entities owing to their superior diversity and versatile physicochemical properties compared to nucleotide bases. A simple permutation of amino acids creates a broad palette of proteins that are successfully engineered as useful bio-functional agents. For example, the intrinsic ultraviolet fluorescence of phenylalanine (F) and tryptophan (W) have been engineered to emit in the visible spectrum [1, 2], that has broad applications as imaging/sensing probes, photothermal therapy agents, optogenetic switches, etc. Read More

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http://dx.doi.org/10.1002/cbic.201900166DOI Listing

Q-switched double-frequency Nd:YAG (532 nm) laser is an effective treatment for racial lip pigmentation.

J Cosmet Dermatol 2019 Apr 9. Epub 2019 Apr 9.

Department of Dermatology, Imam Muhammad ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.

Introduction: Lip darkening is a relatively common condition, especially in the Middle East and Southeast Asia. It is well documented in the literature and generally considered to be multifactorial. The presentation can be physiologic or pathologic and caused by a variety of local or systemic factors. Read More

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http://dx.doi.org/10.1111/jocd.12946DOI Listing
April 2019
1 Read

[Research progress of dyskeratosis congenita].

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Feb;54(2):130-134

Department of Oral Medicine, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Chengdu 610041, China.

Dyskeratosis congenita (DC) is a rare disease and a genetic heterogeneity of bone marrow failure, characterized by muco-cutaneous triad of mucosal leukoplakia, abnormal skin pigmentation, nails dystrophy and often involving multiple organs or systems. The inheritance patterns of DC include X-linked recessive, autosomal dominant and recessive patterns. However, the inheritance patterns in 30%-40% of DC patients remained unknown. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2019.02.010DOI Listing
February 2019
2 Reads

One-year pilot study on the effects of nitisinone on melanin in patients with OCA-1B.

JCI Insight 2019 Jan 24;4(2). Epub 2019 Jan 24.

National Eye Institute and.

Background: Oculocutaneous albinism (OCA) results in reduced melanin synthesis, skin hypopigmentation, increased risk of UV-induced malignancy, and developmental eye abnormalities affecting vision. No treatments exist. We have shown that oral nitisinone increases ocular and fur pigmentation in a mouse model of one form of albinism, OCA-1B, due to hypomorphic mutations in the Tyrosinase gene. Read More

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http://insight.jci.org/articles/view/124387
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http://dx.doi.org/10.1172/jci.insight.124387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413781PMC
January 2019
15 Reads

A case of autonomous cortisol secretion in a patient with subclinical Cushing's syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone.

BMC Endocr Disord 2019 Jan 22;19(1):13. Epub 2019 Jan 22.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Increased urinary free cortisol in response to the oral administration of dexamethasone is a paradoxical reaction mainly reported in patients with primary pigmented nodular adrenocortical disease. Here, we describe the first case of subclinical Cushing's syndrome represented by autonomous cortisol secretion and paradoxical response to oral dexamethasone administration, harboring an activating mutation in the α subunit of the stimulatory G protein (GNAS).

Case Presentation: A 65-year-old woman was diagnosed with subclinical Cushing's syndrome during an evaluation for bilateral adrenal masses. Read More

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http://dx.doi.org/10.1186/s12902-019-0345-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343241PMC
January 2019
2 Reads

PGN_0297 is an essential component of the type IX secretion system (T9SS) in Porphyromonas gingivalis: Tn-seq analysis for exhaustive identification of T9SS-related genes.

Microbiol Immunol 2019 Jan;63(1):11-20

Department of Microbiology and Oral Infection, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8588, Japan.

The type IX secretion system (T9SS) was originally discovered in Porphyromonas gingivalis, one of the pathogenic bacteria associated with periodontal disease and is now known to be present in many members of the phylum Bacteroidetes. The T9SS secretes a number of potent virulence factors, including the highly hydrolytic proteases called gingipains, across the outer membrane in P. gingivalis. Read More

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http://dx.doi.org/10.1111/1348-0421.12665DOI Listing
January 2019
1 Read

Dyskeratosis congenita: presentation of cutaneous triad in a sporadic case.

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Department of Surgery, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Dyskeratosis congenita (DKC) also known as Zinsser-Cole-Engman syndrome is a progressive genetic disease with a classical presentation characterised by a triad of reticulate pigmentation of skin, nail dystrophy and leukoplakia. It may be a multisystem disease with the involvement of haematological, gastrointestinal, genitourinary, neurological, ophthalmic, pulmonary and skeletal system. We report a sporadic case of DKC presenting with poikiloderma, nail dystrophy and oral leukoplakia. Read More

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http://dx.doi.org/10.1136/bcr-2018-226736DOI Listing
November 2018
3 Reads

General hyperpigmentation induced by Grave's disease: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13279

Department of Endocrinology, The Second Affiliated Hospital of Zhejiang University School of Medicine.

Rationale: Hyperpigmentation is a common skin disease. However, there are few reported cases of Grave's disease with diffuse hyperpigmentation. We hereby described a rare case with diffuse hyperpigmentation induced by Grave's disease. Read More

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http://dx.doi.org/10.1097/MD.0000000000013279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310574PMC
December 2018
5 Reads

Craniofacial skeleton of MEXICAN tetra (Astyanax mexicanus): As a bone disease model.

Dev Dyn 2019 02 18;248(2):153-161. Epub 2018 Dec 18.

Department of Oral Biology, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

A small fresh water fish, the Mexican tetra (Astyanax mexicanus) is a novel animal model in evolutionary developmental biology. The existence of morphologically distinct surface and cave morphs of this species allows simultaneous comparative analysis of phenotypic changes at different life stages. The cavefish harbors many favorable constructive traits (i. Read More

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http://doi.wiley.com/10.1002/dvdy.4
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http://dx.doi.org/10.1002/dvdy.4DOI Listing
February 2019
13 Reads

Sub-lethal effects induced by a mixture of different pharmaceutical drugs in predicted environmentally relevant concentrations on Lithobates catesbeianus (Shaw, 1802) (Anura, ranidae) tadpoles.

Environ Sci Pollut Res Int 2019 Jan 8;26(1):600-616. Epub 2018 Nov 8.

Post-Graduation Program in Conservation of Cerrado Natural Resources - Biological Research Laboratory, Goiano Federal Institute-Urutaí Campus, Urutaí, GO, Brazil.

The increasing consumption of medications by humans has negative effects such as the increased disposal of these compounds in the environment. Little is known about how the disposal of a "drug mix" (DM) in aquatic ecosystems can affect their biota. Thus, we evaluated whether the exposure of Lithobates casteibeianus tadpoles to a DM composed of different medication classes (antibiotic, anti-inflammatory, antidepressant, anxiolytic, analgesic, and antacid drugs)-at environmentally relevant concentrations-may change their oral morphology, trigger behavioral disorders, and have mutagenic effects on erythrocyte cells. Read More

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http://link.springer.com/10.1007/s11356-018-3656-9
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http://dx.doi.org/10.1007/s11356-018-3656-9DOI Listing
January 2019
17 Reads

Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier-Hunziker syndrome.

World J Clin Cases 2018 Sep;6(10):322-334

Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, Jiangsu Province, China.

Labial and oral melanotic macules are commonly encountered in a broad range of conditions ranging from physiologic pigmentation to a sign of an underlying life-threatening disease. Although Laugier-Hunziker syndrome (LHS) shares some features of labial and oral pigmentation with a variety of conditions, it is a benign and acquired condition, frequently associated with longitudinal melanonychia. Herein, the demographic, clinical, dermoscopic, and pathological aspects of LHS were reviewed comprehensively. Read More

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http://dx.doi.org/10.12998/wjcc.v6.i10.322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163135PMC
September 2018
4 Reads

Frequency of Pathologic Changes in the Oral Cavity in Patients Subjected to Long-term Pharmacologic Immunosuppressive Therapy After Kidney, Liver, and Hematopoietic Cell Transplantation.

Transplant Proc 2018 Sep 11;50(7):2176-2178. Epub 2018 Apr 11.

Department of General and Transplantation Surgery, Medical University of Warsaw, Warsaw, Poland.

Introduction: Patients subjected to long-term immunosuppressive therapy after organ and cells transplantation are more susceptible than healthy people to the development of the pathologic changes in the oral cavity, including precancerous lesions, oral cancers, lesions following viral infections (herpes simplex virus, Epstein-Barr virus, and cytomegalovirus), fungal infections mainly caused by Candida albicans, drug-induced gingival overgrowth, stomatitis, and tongue disorders.

Material And Methods: Clinical case material included 38 patients after kidney, liver, or blood-forming cells transplantation subjected to various immunosuppressive therapy schemes. The study comprised standard case taking and physical examination of the patient, including detailed intraoral and extraoral stomatological examinations. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.003DOI Listing
September 2018
16 Reads

The role of systemic treatments for skin lightening.

J Cosmet Dermatol 2018 Dec 21;17(6):1144-1157. Epub 2018 Aug 21.

The Ronald O. Perelman Department of Dermatology, New York University Langone Health, New York City, New York.

Background: Pigmentation of the skin occurs as a result of increased melanin production or deposition due to various reasons including age, hormonal imbalances, endocrine disease, inflammation, and/or exposure to damaging radiation, resulting in dermatologic conditions such as lentigines, melasma, or postinflammatory hyperpigmentation. Although numerous topical therapies exist for skin lightening, they are limited by efficacy and pigmentation recurrence after treatment cessation. New research into systemic therapies for hyperpigmentation has been promising. Read More

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http://doi.wiley.com/10.1111/jocd.12747
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http://dx.doi.org/10.1111/jocd.12747DOI Listing
December 2018
27 Reads

An outbreak of Coxsackievirus A6-associated hand, foot, and mouth disease in a kindergarten in Beijing in 2015.

BMC Pediatr 2018 08 21;18(1):277. Epub 2018 Aug 21.

Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, No. 10 Xitoutiao, You'anmen Wai, Fengtai District, Beijing, 100069, People's Republic of China.

Background: Coxsackievirus A6 (CVA6) is one of the major agents to cause hand, foot and mouth disease (HFMD) outbreaks globally. The objective of this study is to investigate the epidemiologic and clinical manifestations of CVA6 outbreak, and thus guide the diagnosis and treatment of the disease, as well as disease prevention.

Methods: An HFMD outbreak in a kindergarten was reported to Shijingshan District Center for Disease Control and Prevention (SCDC) on November 2, 2015 in Beijing, China. Read More

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http://dx.doi.org/10.1186/s12887-018-1253-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103857PMC
August 2018
5 Reads
1.920 Impact Factor

Pigmented (melanotic) diffuse neurofibroma of the back in neurofibromatosis type 1.

GMS Interdiscip Plast Reconstr Surg DGPW 2018 3;7:Doc04. Epub 2018 Aug 3.

Institute of Neuropathology, Eppendorf University Hospital, University of Hamburg, Hamburg, Germany.

Neurofibromatosis type 1 (NF1) is a tumor predisposition disease. Multiple neurofibromas are among the characteristic tumors of NF1. The report describes the diagnosis and treatment of a large spinal neurofibroma in a NF1 patient. Read More

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http://dx.doi.org/10.3205/iprs000124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073164PMC
August 2018
8 Reads

Galli-Galli Disease Presenting as a Lentigo-like Eruption: A Further Clinical Feature in the Wide Spectrum of Reticulate Pigment Disorders.

Acta Dermatovenerol Croat 2017 Dec;25(4):300-302

Dario Didona, MD, Prima Divisione Dermatologia Istituto Dermopatico dell'Immacolata, Via dei Monti di Creta 104, 00167 Rome , Italy;

Dear Editor, Reticulate pigmentary disorders (RPD) is a term used to classify a spectrum of several acquired and congenital disorders. Different clinical features can be present, including a reticular pattern and a freckle-like pattern with hyper- or hypo-pigmented macules (1). Dowling-Degos disease (DDD), an autosomal dominant genodermatosis, is the main type of RPD (2). Read More

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December 2017
13 Reads

Hair analysis to monitor adherence to prescribed chronic inhaler drug therapy in patients with asthma or COPD.

Pulm Pharmacol Ther 2018 08 4;51:59-64. Epub 2018 Jul 4.

GSK, Stockley Park West, Uxbridge, Middlesex, UK.

Background: Poor adherence to inhaled drug therapy in individuals with asthma and/or chronic obstructive pulmonary disease (COPD) may be associated with suboptimal therapeutic outcomes. Measurement of drug residues in hair samples has been employed to assess oral medication use over time. Here, we test the feasibility of analyzing hair samples from patients with asthma and/or COPD for assessing adherence to prescribed inhaled medication. Read More

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http://dx.doi.org/10.1016/j.pupt.2018.07.001DOI Listing
August 2018
4 Reads

Non-plaque-induced gingival diseases.

J Periodontol 2018 Jun;89 Suppl 1:S28-S45

Department of Periodontology, University of Giessen, Giessen, Germany.

While plaque-induced gingivitis is one of the most common human inflammatory diseases, several non-plaque-induced gingival diseases are less common but often of major significance for patients. The non-plaque-induced gingival lesions are often manifestations of systemic conditions, but they may also represent pathologic changes limited to gingival tissues. A classification is proposed, based on the etiology of the lesions and includes: Genetic/Developmental disorders; Specific infections; Inflammatory and immune conditions and lesions; Reactive processes; Neoplasms; Endocrine, Nutritional and metabolic diseases; Traumatic lesions; and Gingival pigmentation. Read More

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http://doi.wiley.com/10.1002/JPER.17-0163
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http://dx.doi.org/10.1002/JPER.17-0163DOI Listing
June 2018
20 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Periodontol 2018 Jun;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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http://doi.wiley.com/10.1002/JPER.17-0719
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http://dx.doi.org/10.1002/JPER.17-0719DOI Listing
June 2018
42 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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http://dx.doi.org/10.1111/jcpe.12940DOI Listing
June 2018
66 Reads

Non-plaque-induced gingival diseases.

J Clin Periodontol 2018 Jun;45 Suppl 20:S28-S43

Department of Periodontology, University of Giessen, Giessen, Germany.

While plaque-induced gingivitis is one of the most common human inflammatory diseases, several non-plaque-induced gingival diseases are less common but often of major significance for patients. The non-plaque-induced gingival lesions are often manifestations of systemic conditions, but they may also represent pathologic changes limited to gingival tissues. A classification is proposed, based on the etiology of the lesions and includes: Genetic/Developmental disorders; Specific infections; Inflammatory and immune conditions and lesions; Reactive processes; Neoplasms; Endocrine, Nutritional and metabolic diseases; Traumatic lesions; and Gingival pigmentation. Read More

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http://doi.wiley.com/10.1111/jcpe.12938
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http://dx.doi.org/10.1111/jcpe.12938DOI Listing
June 2018
36 Reads

Dyskeratosis congenita with a novel genetic variant in the DKC1 gene: a case report.

BMC Med Genet 2018 05 25;19(1):85. Epub 2018 May 25.

Human Genetics Unit, Faculty of Medicine, University of Colombo, Kynsey Road, Colombo 8, Sri Lanka.

Background: Dyskeratosis congenita (DC) is a rare genetic disorder of bone marrow failure inherited in an X-linked, autosomal dominant or autosomal recessive pattern. It has a wide array of clinical features and patients may be cared for by many medical sub specialties. The typical clinical features consist of lacy reticular skin pigmentation, nail dystrophy and oral leukoplakia. Read More

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http://dx.doi.org/10.1186/s12881-018-0584-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970516PMC
May 2018
12 Reads
2.083 Impact Factor

Effect of Fixed Metallic Oral Appliances on Oral Health.

Authors:
Ahmad Alnazzawi

J Int Soc Prev Community Dent 2018 Mar-Apr;8(2):93-98. Epub 2018 Apr 24.

Department of Substitutive Dental Sciences, College of Dentistry, Taibah University Madinah, KSA.

There is a substantial proportion of the population using fixed metallic oral appliances, such as crowns and bridges, which are composed of various dental alloys. These restorations may be associated with a number of effects on oral health with variable degrees of severity, to review potential effects of using fixed metallic oral appliances, fabricated from various alloys. The MEDLINE/PubMed database was searched using certain combinations of keywords related to the topic. Read More

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http://dx.doi.org/10.4103/jispcd.JISPCD_416_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946530PMC
April 2018
21 Reads

Hidradenitis Suppurativa, Metabolic Syndrome, and Demodex spp. Infestation.

Turkiye Parazitol Derg 2018 Jun;42(2):171-174

Department of Endocrinology, Ankara Yıldırım Beyazıt University, Yenimahalle Training and Research Hospital, Ankara, Turkey.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. This type of dermatosis with underlying chronic inflammation significantly affects the quality of life and may be accompanied by many comorbidities. In this case, Demodex spp. Read More

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http://turkiyeparazitolderg.org/eng/makale/1094/72/Full-Text
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http://dx.doi.org/10.5152/tpd.2018.5330DOI Listing
June 2018
18 Reads

Beginning at the ends: telomeres and human disease.

Authors:
Sharon A Savage

F1000Res 2018 1;7. Epub 2018 May 1.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

Studies of rare and common illnesses have led to remarkable progress in the understanding of the role of telomeres (nucleoprotein complexes at chromosome ends essential for chromosomal integrity) in human disease. Telomere biology disorders encompass a growing spectrum of conditions caused by rare pathogenic germline variants in genes encoding essential aspects of telomere function. Dyskeratosis congenita, a disorder at the severe end of this spectrum, typically presents in childhood with the classic triad of abnormal skin pigmentation, nail dystrophy, and oral leukoplakia, accompanied by a very high risk of bone marrow failure, cancer, pulmonary fibrosis, and other medical problems. Read More

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http://dx.doi.org/10.12688/f1000research.14068.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931273PMC
May 2018
1 Read

Green Bone: Minocycline-Induced Discoloration of Bone Rarely Reported in Foot and Ankle.

J Foot Ankle Surg 2018 Jul - Aug;57(4):801-807. Epub 2018 May 7.

PGY-IV, Fellow, Department of Surgery, American Health Network, Indianapolis, IN.

The tetracycline antibiotics incorporate into bone similar to bisphosphonates. Tetracycline stains bone a fluorescent yellow and minocycline, more commonly used for chronic acne, stains bone dark green. Owing to its frequent use, the occurrence of green bone discoloration due to antibiotics in the tetracycline class is well understood. Read More

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http://dx.doi.org/10.1053/j.jfas.2017.11.009DOI Listing
December 2018
27 Reads

Complex phenotype of dyskeratosis congenita and mood dysregulation with novel homozygous RTEL1 and TPH1 variants.

Am J Med Genet A 2018 06 25;176(6):1432-1437. Epub 2018 Apr 25.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Rockville, Maryland.

Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome caused by germline mutations in telomere biology genes. Patients have extremely short telomeres for their age and a complex phenotype including oral leukoplakia, abnormal skin pigmentation, and dysplastic nails in addition to bone marrow failure, pulmonary fibrosis, stenosis of the esophagus, lacrimal ducts and urethra, developmental anomalies, and high risk of cancer. We evaluated a patient with features of DC, mood dysregulation, diabetes, and lack of pubertal development. Read More

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http://dx.doi.org/10.1002/ajmg.a.38706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992073PMC
June 2018
35 Reads

Close and regular surveillance is key to prevent severe complications for Peutz-Jeghers syndrome patients without gastrointestinal polyps: case report of a novel STK11 mutation (c.471_472delCT) in a Chinese girl.

BMC Surg 2018 Apr 23;18(1):24. Epub 2018 Apr 23.

Department of Gastroenterology, Airforce General Hospital of PLA, 30 Fucheng Rd, Beijing, 100142, China.

Background: Peutz-Jeghers syndrome (PJS) is a Mendelian disease characterized by gastrointestinal hamartomas, mucocutaneous pigmentation (MP), and increased cancer risk. Serine/threonine kinase 11 (STK11) is the only validated causative gene in PJS. Clinical observation reveals MP and intussusception in childhood are more frequent and severe than in adults. Read More

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http://dx.doi.org/10.1186/s12893-018-0357-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914036PMC
April 2018
5 Reads

Atopic labial pigmentation: a new diagnostic feature in Asian patients with atopic dermatitis.

Int J Dermatol 2018 Jul 23;57(7):817-821. Epub 2018 Apr 23.

Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.

Background: Pigmented lesions on the lips can be caused by physiological or pathological factors, along with exogenous or endogenous factors. Many patients with atopic dermatitis (AD) and labial pigmentation are seen in clinical practice. The aim of our study was to further explore the association of labial pigmentation and AD. Read More

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http://dx.doi.org/10.1111/ijd.14010DOI Listing
July 2018
6 Reads

Pigmented squamous cell carcinoma: case report and importance of differential diagnosis.

An Bras Dermatol 2018 Jan-Feb;93(1):96-98

Division of Surgery at Fundação Alfredo da Matta (FUAM) - Manaus (AM), Brazil.

A few cases of pigmented squamous cell carcinoma affecting the skin and the ocular and oral mucosa of the elderly have been described in the literature. The disease manifests itself as papular and nodular erythematous or pigmented lesions. The main clinical differential diagnoses are pigmented basal cell carcinoma and melanoma. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20186757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871370PMC
April 2018
7 Reads

Case Report: Dermoscopic features of oral lichen planus - the evolution of mucoscopy.

F1000Res 2018 6;7:284. Epub 2018 Mar 6.

Department of Dermatology, College of Medicine, King Faisal University, Hofuf, Saudi Arabia.

Dermoscopy, a non-invasive technique for cutaneous diagnosis is being increasingly studied in various disorders of the skin, nails and scalp. However, it has been under-utilized for the diagnosis and characterization of mucosal disorders. The dermoscopic characterization of cutaneous lichen planus and its variants has been well documented with Wickham's striae constituting the hallmark of the condition. Read More

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http://dx.doi.org/10.12688/f1000research.14134.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861519.2PMC
March 2018
19 Reads

Double-blind, Placebo-controlled Trial to Evaluate the Effectiveness of Extract in the Treatment of Melasma in Asian Skin: A Pilot Study.

J Clin Aesthet Dermatol 2018 Mar 1;11(3):14-19. Epub 2018 Mar 1.

Drs. Goh, Chuah, and Thng are with the National Skin Centre in Singapore.

Melasma is a common pigmentary disorder with a multifactorial etiology that can hinder its management. The aqueous extract of the fern (PLE), Fernblock (IFC, Madrid, Spain), has demonstrated antioxidant and photoprotective activities and has been used for the treatment of several pigmentary disorders. The aim of this study was to evaluate the efficacy and safety of oral PLE in the treatment of melasma in Asian patients. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868779PMC
March 2018
6 Reads

Micro - Focused Phototherapy Associated To Janus Kinase Inhibitor: A Promising Valid Therapeutic Option for Patients with Localized Vitiligo.

Open Access Maced J Med Sci 2018 Jan 21;6(1):46-48. Epub 2018 Jan 21.

University G. Marconi of Rome, Dermatology and Venereology, Rome, Italy.

Background: Vitiligo is an acquired pigmentary cutaneous disease, characterised by the progressive loss of melanocytes, resulting in hypopigmented skin areas which progressively become amelanotic. Classically, vitiligo treatments are unsatisfactory and challenging. Despite the continuous introduction of new therapies, phototherapy is still the mainstay for vitiligo repigmentation. Read More

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http://dx.doi.org/10.3889/oamjms.2018.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816312PMC
January 2018
27 Reads

Functional and cosmetic donor site morbidity of the radial forearm-free flap: comparison of two different coverage techniques.

Eur Arch Otorhinolaryngol 2018 May 26;275(5):1219-1225. Epub 2018 Feb 26.

Clinic of Otolaryngology, Head and Neck Surgery and Department of Head Medicine and Oral Health, University Hospital Leipzig, Liebigstr. 12, 04103, Leipzig, Germany.

Background: The use of the radial forearm-free flap is a well-established and reliable reconstruction method in head and neck surgery. Usually, the defect of the donor site is covered with full or split-thickness skin grafts. Since 09/2013, a direct closure of the radial forearm donor site has been performed at the ENT University Hospital Leipzig to avoid secondary donor site morbidity. Read More

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http://dx.doi.org/10.1007/s00405-018-4908-5DOI Listing
May 2018
15 Reads

An unusual presentation of primary cutaneous amyloidosis.

Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.

Department of Dermatology and STD, Lady Hardinge Medical College. New Delhi, India.

Primary localized cutaneous amyloidosis refers to a group of disorders characterized by deposition of amyloid in the dermis without any systemic involvement. It comprises the following clinical types: macular, lichenoid, nodular, and biphasic. There are also rare variants such as amyloidosis cutis dyscromica and poikiloderma-like cutaneous amyloidosis. Read More

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August 2017
16 Reads

Cowden syndrome: clinical case and a brief review.

Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.

Department of Dermatology and Venereology, Centro Hospitalar São João EPE, Porto, Portugal.

Cowden syndrome is a rare genodermatosis of autosomal dominant inheritance characterized by multiple hamartomas in several organs and an increased risk of malignancies. We present the case of a 53-year-old man with a history of benign and malignant thyroid disease, intestinal polyposis, and Chiari malformation. He had several trichilemmomas, papillomatosis of the oral cavity, macular pigmentation of the glans penis, among other clinical features suggestive of Cowden syndrome. Read More

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August 2017
3 Reads

Health Survey of Adults with Neurofibromatosis 1 Compared to Population Study Controls.

J Genet Couns 2018 Sep 10;27(5):1102-1110. Epub 2018 Feb 10.

Frambu Resource Centre for Rare Disorders, Sandbakkvn 18, Siggerud, Norway.

Neurofibromatosis type 1 (NF1) is a genetic, autosomal dominant multi-organ disease characterized by susceptibility to tumor formation, changes in skin pigmentation, skeletal abnormalities, and neuropsychological deficits. Clinical studies have shown impaired health-related quality of life (HQoL) in adults with NF1. However, little is known about HQoL in non-clinical NF1 samples. Read More

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http://dx.doi.org/10.1007/s10897-018-0229-5DOI Listing
September 2018
4 Reads

Longitudinal observation of subretinal fibrosis in Vogt-Koyanagi-Harada disease.

BMC Ophthalmol 2018 Jan 15;18(1). Epub 2018 Jan 15.

Ophthalmology Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing, 100730, China.

Background: Subretinal fibrosis (SRF) is a vision-threatening complication of Vogt-Koyanagi-Harada disease (VKH). It has long been recognized as a sequela of chronic inflammation. The developmental process of SRF, however, has not been described. Read More

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http://dx.doi.org/10.1186/s12886-018-0670-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769357PMC
January 2018
6 Reads

Oral mucosa lesions and gingival bleeding can indicate the progression of liver disease in children and adolescents aged two to 18 years.

Acta Paediatr 2018 May 24;107(5):886-892. Epub 2018 Jan 24.

Department of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, Children's Memorial Health Institute, Warsaw, Poland.

Aim: This study assessed correlations between systemic disturbances of paediatric chronic liver diseases (CLD) and oral symptoms in subjects aged 2-18 years.

Methods: It was carried out during outpatient appointments at the Children's Memorial Health Institute, Warsaw, Poland, from 2010 to 2015 and comprised 52 CLD patients with a mean age of 12.3 ± 4. Read More

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http://dx.doi.org/10.1111/apa.14213DOI Listing
May 2018
23 Reads

Diseases of the lips.

Clin Dermatol 2017 Sep - Oct;35(5):e1-e14. Epub 2017 Nov 16.

Department of Oral Pathology, Medicine, Radiology, Indiana University School of Dentistry, Indianapolis, IN; Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN.

Heath care providers should be comfortable with normal as well as pathologic findings in the lips, because the lips are highly visible and may display clinical manifestations of local, as well as systemic inflammatory, allergic, irritant, and neoplastic alterations. Fortunately, the lips are easily accessible. The evaluation should include a careful history and physical examination, including visual inspection, as well as palpation of the lips and an examination of associated cervical, submandibular, and submental nodes. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2017.11.003DOI Listing
August 2018
5 Reads

A Novel Generalized Lipodystrophy-Associated Progeroid Syndrome Due to Recurrent Heterozygous LMNA p.T10I Mutation.

J Clin Endocrinol Metab 2018 03;103(3):1005-1014

Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, UT Southwestern Medical Center, Dallas, Texas.

Background: Lamin A/C (LMNA) gene mutations cause a heterogeneous group of progeroid disorders, including Hutchinson-Gilford progeria syndrome, mandibuloacral dysplasia, and atypical progeroid syndrome (APS). Five of the 31 previously reported patients with APS harbored a recurrent de novo heterozygous LMNA p.T10I mutation. Read More

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https://academic.oup.com/jcem/article/103/3/1005/4743225
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http://dx.doi.org/10.1210/jc.2017-02078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283411PMC
March 2018
41 Reads

Facial Acanthosis Nigricans: A Morphological Marker of Metabolic Syndrome.

Indian J Dermatol 2017 Nov-Dec;62(6):591-597

Department of Dermatology, Dr B. C. Roy Post Graduate Institute of Pediatric Sciences, Kolkata, West Bengal, India.

Introduction: Acanthosis nigricans (AN) is a frequently encountered entity. Facial AN (FAN) is a subset of AN which is being increasingly recognized. Recently, reports hypothesizing the association of FAN with features of metabolic syndrome have been published. Read More

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http://dx.doi.org/10.4103/ijd.IJD_545_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724306PMC
December 2017
3 Reads

A novel germline mutation (c.A527G) in STK11 gene causes Peutz-Jeghers syndrome in a Chinese girl: A case report.

Medicine (Baltimore) 2017 Dec;96(49):e8591

aDepartment of Medical Genetics, Naval Medical University, Shanghai 200433, ChinabHebei North University, Zhangjiakou, Hebei Province, ChinacDepartment of Gastroenterology, Airforce General Hospital of PLA, Beijing, China.

Rationale: Peutz-Jeghers syndrome (PJS) is a Mendelian autosomal dominant disease caused by mutations in the tumor suppressor gene, serine/threonine kinase 11 (STK11). The features of this syndrome include gastrointestinal (GI) hamartomas, melanin spots on the lips and the extremities, and an increased risk of developing cancer. Early onset of disease is often characterized by mucocutaneous pigmentation and intussusception due to GI polyps in childhood. Read More

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http://dx.doi.org/10.1097/MD.0000000000008591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728834PMC
December 2017
11 Reads

Whole-exome sequencing of oral mucosal melanoma reveals mutational profile and therapeutic targets.

J Pathol 2018 Mar 5;244(3):358-366. Epub 2018 Feb 5.

Bio-X Institutes, Ministry of Education Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Institute of Social Cognitive and Behavioral Sciences, Shanghai Jiao Tong University, Shanghai, PR China.

Oral mucosal melanoma (OMM) is a rare and aggressive subtype of melanoma with little known about its pathogenesis or carcinogenesis. We therefore performed whole-exome sequencing (WES) on 19 matched OMM tumor/normal pairs in order to gain insight into potential genetic drivers of tumor formation. For the first time, we describe the comprehensive mutational profile of OMM. Read More

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http://dx.doi.org/10.1002/path.5017DOI Listing
March 2018
11 Reads

Gingival depigmentation using Er:YAG laser and scalpel technique: A six-month prospective clinical study.

Quintessence Int 2018 ;49(2):113-122

Objective: To compare the 6-month clinical efficacy of Er:YAG laser and standard scalpel technique in treating gingival hyperpigmentation.

Method And Materials: Patients requesting treatment for moderate to severe gingival hyperpigmentation in the maxilla were enrolled in this split-mouth study. The contralateral maxillary sides were randomly assigned to receive either Er:YAG laser (continuous wavelength of 2,940 nm) with a noncontact tip or the standard scalpel technique. Read More

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http://dx.doi.org/10.3290/j.qi.a39267DOI Listing
October 2018
20 Reads

Oral leukoplakia and proliferative verrucous leukoplakia: a review for dental practitioners.

Authors:
K Staines H Rogers

Br Dent J 2017 Dec 3;223(9):655-661. Epub 2017 Nov 3.

Oral Medicine, Bristol Dental Hospital and School, Lower Maudlin Street, Bristol, BS1 2LY, United Kingdom.

Objectives To provide an overview of the current thinking in terms of the diagnosis and management of oral leukoplakia and proliferative verrucous leukoplakia as relevant to general dental practitioners.Data sources, data selection, data extraction, data synthesis We searched the MEDLINE Ovid, EMBASE databases and the Cochrane Library, (1990 to 16 April 2017), restricting our search to English language with the following key words: leukoplakia, white patch, proliferative verrucous leukoplakia, precancerous lesion, premalignant lesions, potentially malignant oral conditions and potentially malignant oral disorders. The two authors selected key papers and engaged in collaborative data extraction and synthesis of the selected reference material. Read More

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http://dx.doi.org/10.1038/sj.bdj.2017.881DOI Listing
December 2017
10 Reads

Correlation of mucocutaneous manifestations of HIV-infected patients in an ART center with CD4 counts.

Indian J Dent Res 2017 Sep-Oct;28(5):549-554

Department of Oral and Maxillofacial Pathology, Vokkaligara Sangha Dental College, Bengaluru, Karnataka, India.

Background: As the search for reliable clinical indicators for management of human immunodeficiency virus/AIDS continues, mucocutaneous manifestations of HIV are considered among key clinical indicators for prediction of underlying degree of immunosuppression, systemic opportunistic infections, and disease progression.

Objectives: (1) To study the prevalence of mucocutaneous manifestations in HIV-seropositive patients attending the ART center of our hospital (2) To correlate mucocutaneous manifestations with CD4 cell counts.

Materials And Methods: A total of 200 HIV-seropositive patients of adult age group visiting our hospital were included in the study. Read More

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http://dx.doi.org/10.4103/ijdr.IJDR_352_16DOI Listing
July 2018
4 Reads

Vitamin D and the Skin: An Update for Dermatologists.

Am J Clin Dermatol 2018 Apr;19(2):223-235

Department of Dermatology, Hôpital Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.

Vitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms. Read More

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http://dx.doi.org/10.1007/s40257-017-0323-8DOI Listing
April 2018
10 Reads

Identification of genes encoding glycosyltransferases involved in lipopolysaccharide synthesis in Porphyromonas gingivalis.

Mol Oral Microbiol 2018 02 17;33(1):68-80. Epub 2017 Nov 17.

Department of Microbiology and Oral Infection, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Porphyromonas gingivalis can synthesize both A-LPS and O-LPS lipopolysaccharides, which contain anionic O-polysaccharides and conventional O-polysaccharides, respectively. A-LPS can anchor virulence proteins to the cell surface, so elucidating the mechanism of A-LPS synthesis is important for understanding the pathogenicity of this bacterium. To identify the genes involved in LPS synthesis, we focused on uncharacterized genes encoding the glycosyltransferases, PGN_0361, PGN_1239, PGN_1240 and PGN_1668, which were tentatively named gtfC, gtfD, gtfE and gtfF, respectively, and characterized their mutants. Read More

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http://dx.doi.org/10.1111/omi.12200DOI Listing
February 2018
9 Reads