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    1106 results match your criteria Disorders of Oral Pigmentation

    1 OF 23

    Melasma: an Up-to-Date Comprehensive Review.
    Dermatol Ther (Heidelb) 2017 Jul 19. Epub 2017 Jul 19.
    Ronald O. Perelman Department of Dermatology, New York University, New York, NY, USA.
    Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types. Multiple etiologies, including light exposure, hormonal influences, and family history, have been implicated in the pathogenesis of this disorder. Overall prevalence ranges widely at 1-50%, since values are typically calculated within a specific ethnic population within a geographic region. Read More

    Multifocal oral melanoacanthoma associated with Addison's disease and hyperthyroidism: a case report.
    Arch Endocrinol Metab 2017 Jun 26. Epub 2017 Jun 26.
    Divisão de Patologia Oral, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brasil.
    Oral melanoacanthoma is a mucocutaneous, pigmented, rare, benign, and probably reactive lesion. This paper reports for the first time in the literature a case of multifocal oral melanoacanthoma in a patient diagnosed with Addison's disease and concomitant Graves' disease with hyperthyroidism. The patient presented with oral pigmented lesions, which were hypothesized to be mucosal pigmentation associated with Addison's disease. Read More

    Retrospective study on the characteristics and treatment of late-onset vitiligo.
    Indian J Dermatol Venereol Leprol 2017 Jun 27. Epub 2017 Jun 27.
    National Skin Centre; Skin Research Institue of Singapore, ASTAR, Singapore.
    Background: Late-onset vitiligo, defined as being aged 50 years and above at the point of clinical onset, remains poorly characterized till now.

    Aim: This study aims to describe the clinical characteristics and treatment response of patients with late-onset vitiligo.

    Methods: We retrospectively reviewed the case records of all patients diagnosed with late-onset vitiligo, from January 1, 2010 to December 31, 2014. Read More

    [Efficacy and safety of Xiaoaiping combined with chemotherapy in the treatment of advanced esophageal cancer].
    Zhonghua Zhong Liu Za Zhi 2017 Jun;39(6):453-457
    Department of Oncology, Huaihe Hospitalof Henan University, Kaifeng, 475000, China.
    Objective: To evaluate the efficacy and safety of Xiaoaiping combined with chemotherapy in the treatment of advanced esophageal cancer. Methods: This is a multi-center, randomized, open label and parallel controlled study. A total of 124 advanced esophageal cancer patients with Karnofsky Performance Status (KPS) score ≥60 and expected survival time≥3 months were enrolled. Read More

    Laugier-Hunziker syndrome: a case of asymptomatic mucosal and acral hyperpigmentation.
    Dermatol Pract Concept 2017 Apr 30;7(2):27-30. Epub 2017 Apr 30.
    Department of Dermatology, University Hospital Zurich, Zurich Switzerland.
    Laugier-Hunziker syndrome (LHS) is a rare condition characterized by acquired hyperpigmentation involving the lips, oral mucosa, acral surfaces, nails and perineum. While patients with LHS may manifest pigmentation in all of the aforementioned areas, most present with pigmentation localized to only a few of these anatomical sites. We herein report a patient exhibiting the characteristic pigment distribution pattern associated with LHS. Read More

    Using Tn-seq To Identify Pigmentation-Related Genes of Porphyromonas gingivalis: Characterization of the Role of a Putative Glycosyltransferase.
    J Bacteriol 2017 Jul 27;199(14). Epub 2017 Jun 27.
    Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts, USA
    Cellular pigmentation is an important virulence factor of the oral pathogen Porphyromonas gingivalis Pigmentation has been associated with many bacterial functions, including but not limited to colonization, maintaining a local anaerobic environment by binding oxygen molecules, and defense against reactive oxygen species (ROS) produced by immune cells. Pigmentation-associated loci identified to date have involved lipopolysaccharide, fimbriae, and heme acquisition and processing. We utilized a transposon mutant library of P. Read More

    [Pigmentations of the oral cavity].
    Presse Med 2017 Mar 12;46(3):303-319. Epub 2017 Apr 12.
    Institut universitaire du cancer, Toulouse Oncopole 1, oncodermatologie et consultation pluridisciplinaire de pathologies buccales, avenue Irène-Joliot-Curie, 31100 Toulouse, France.
    Buccal mucosa color is explained by hemoglobin in the vessels and melanin in the epithelium. Abnormal presence of melanin pigments (hypermelaninosis, hypermelanocytosis), hematic pigments (hemoglobin, hemosiderin, iron) but also some exogenous circonstancies explain pigmented lesions (figure 1). These lesions could be localized (single lesions), multifocal (multiple lesions) or diffused. Read More

    The Role of Diet and Supplements in Vitiligo Management.
    Dermatol Clin 2017 Apr;35(2):235-243
    Vitiligo & Pigmentation Institute of Southern California, 5670 Wilshire Boulevard, #650, Los Angeles, CA 90036, USA.
    Vitiligo is an autoimmune disorder that involves the interplay between oxidative stress and the immune system. Preliminary observations suggest that the presence of gluten in the diet may play a role in vitiligo development in some patients, but to date vitiligo-specific diets have not been studied. The role of oral supplements, including vitamins, minerals, and botanicals, is increasingly being investigated as adjuncts to conventional medical treatment due to their antioxidant and immunomodulatory activity. Read More

    Multicenter, randomized, open-label Phase II study comparing S-1 alternate-day oral therapy with the standard daily regimen as a first-line treatment in patients with unresectable advanced pancreatic cancer.
    Cancer Chemother Pharmacol 2017 Apr 1;79(4):813-823. Epub 2017 Mar 1.
    Kitasato Institute for Life Science, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
    Purpose: Non-inferiority for overall survival (OS) following alternate-day treatment with the oral anticancer drug S-1 compared with standard daily treatment was assessed in Japanese patients with unresectable advanced pancreatic cancer in a multicenter, randomized, phase II study. This trial was registered at the UMIN Clinical Trials Registry (no. 000008604). Read More

    African ancestry is associated with facial melasma in women: a cross-sectional study.
    BMC Med Genet 2017 Feb 17;18(1):17. Epub 2017 Feb 17.
    Department of Dermatology, FMB-Unesp, Botucatu, SP, Brazil.
    Background: Melasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in different populations. Read More

    Common Skin Conditions in Children: Noninfectious Rashes.
    FP Essent 2017 Feb;453:18-25
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

    Pharmacokinetics and Pharmacodynamics of Afamelanotide and its Clinical Use in Treating Dermatologic Disorders.
    Clin Pharmacokinet 2017 Aug;56(8):815-823
    Stadtspital Triemli, Institute of Laboratory Medicine, Zurich, Switzerland.
    Afamelanotide, the first α-melanocyte-stimulating hormone (MSH) analogue, synthesized in 1980, was broadly investigated in all aspects of pigmentation because its activity and stability were higher than the natural hormone. Afamelanotide binds to the melanocortin-1 receptor (MC1R), and MC1R signaling increases melanin synthesis, induces antioxidant activities, enhances DNA repair processes and modulates inflammation. The loss-of-function variants of the MC1R present in fair-skinned Caucasians are less effectively activated by the natural hormone. Read More

    Dermatological adverse events with taxane chemotherapy.
    Eur J Dermatol 2016 Oct;26(5):427-443
    Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    Taxanes (docetaxel and paclitaxel) are among the most commonly prescribed anticancer drugs approved for the treatment of metastatic or locally advanced breast, non-small cell lung, prostate, gastric, head and neck, and ovarian cancers, as well as in the adjuvant setting for operable node-positive breast cancers. Although the true incidence of dermatological adverse events (AEs) in patients receiving taxanes is not known, and has never been prospectively analysed, they clearly represent one of the major AEs associated with these agents. With an increase in the occurrence of cutaneous AEs during treatment with novel targeted and immunological therapies when used in combination with taxanes, a thorough understanding of reactions attributable to this class is imperative. Read More

    Trauma due to Self-aggression in Patient with Waardenburg Syndrome associated with Congenital Anomalies.
    J Contemp Dent Pract 2016 Aug 1;17(8):702-5. Epub 2016 Aug 1.
    Department of Dentistry, Universidade do Sagrado Coração, São Paulo, Brazil.
    Waardenburg syndrome (WS) is an inherited autosomal dominant genetic disorder presenting variable penetrance and expressivity, with an estimated prevalence of 1:42,000. Clinical characteristics of WS include lateral displacement of the internal eye canthus, hyperplasia of the medial portion of the eyebrows, prominent and broad nasal base, congenital deafness, pigmentation of the iris and skin, and white forelock. A 24-year-old male patient, previously diagnosed with WS, was referred to the Special Needs Dental Clinic of Sacred Heart University, Bauru, Brazil. Read More

    Salt and Pepper Pigmentation - Skin Manifestation of Systemic Sclerosis.
    J Assoc Physicians India 2015 Sep;63(9):70
    Postgraduate Student, Dept. of General Medicine, Govt. Mohan Kumaramangalam Medical College and Hospital, Salem, Tamil Nadu.
    A 50 year old male presented with progressive difficulty in swallowing both liquid and solid food with no history of Raynaud's phenomenon. A general examination revealed skin changes in the form of thickening, hyperpigmentation and tightening of skin of fingers, hand, forearm and legs. The patient had painless skin induration over the legs, forearm and hand. Read More

    Dyskeratosis congenita presenting with dysphagia.
    Indian Dermatol Online J 2016 Jul-Aug;7(4):275-7
    Department of Dermatology, Venereology and Leprosy, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.
    Dyskeratosiscongenita (DKC) is a genetically heterogeneous disease of defective telomere maintenance that may demonstrate different patterns of inheritance. It is characterized by thetriad of dystrophy of the nails, leukokeratosis of the oral mucosa, and extensive net-like pigmentation of the skin. We report a case ofDKC who presented with a chief complaint of dysphagia. Read More

    [Laugier-Hunziker syndrome in a patient with Sjögren’s syndrome: Report of one case].
    Rev Med Chil 2016 May;144(5):671-4
    Laugier-Hunziker syndrome is a rare benign idiopathic condition characterized by acquired macular pigmentation of lips and buccal mucosa, often accompanied with melanonychia. The main concern with this condition is to rule out other differential diagnosis with systemic repercussions and similar hyperpigmentation patterns, such as Peutz-Jeghers syndrome, adrenal insufficiency and melanoma. We report a 58-year-old female with a 20-year history of Sjögren’s syndrome, presenting with melanonychia and hyperpigmentation in the buccal mucosa. Read More

    Prurigo Pigmentosa-Report of 3 Cases From Brazil and Literature Review.
    Am J Dermatopathol 2017 Apr;39(4):267-274
    *Departments of Dermatology and Pathology, Hospital Federal de Bonsucesso, Rio de Janeiro, Brazil; †Department of Dermatology, Hospital Federal de Bonsucesso, Rio de Janeiro, Brazil; ‡Department of Dermatology, Hospital Universitário Gafrée e Guinle, Rio de Janeiro, Brazil; §Detartment of Dermatology, Hospital Federal Servidores do Estado, Rio de Janeiro, Brazil; and ¶ID-Investigação em Dermatologia, dermatopathology consultive services, Rio de Janeiro, Brazil.
    Prurigo pigmentosa (PP) is a rare inflammatory disease of the skin of uncertain etiology first reported in Japan. It is typified by recurrent eruptions of itching urticarial macules, papules, vesicopapules, and plaques with a reticular arrangement that quickly resolve leaving a net-like pigmentation. The disease presents specific histopathological features. Read More

    The role of systemic steroids and phototherapy in the treatment of stable vitiligo: a randomized controlled trial.
    Dermatol Ther 2016 Nov 16;29(6):406-412. Epub 2016 Aug 16.
    Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
    Pathogenesis of vitiligo is believed to be multifactorial disease with a wide variety of therapeutic modalities. The aim of this work is to assess the efficacy of oral mini-pulse steroids (OMP) plus Nb-U.V. Read More

    Combination therapy of orally administered glycyrrhizin and UVB improved active-stage generalized vitiligo.
    Braz J Med Biol Res 2016 Jul;49(8)
    Center for Translational Medicine, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
    Glycyrrhizin has been used clinically for several years due to its beneficial effect on immunoglobulin E (IgE)-induced allergic diseases, alopecia areata and psoriasis. In this study, glycyrrhizin, ultraviolet B light (UVB) or a combination of both were used to treat active-stage generalized vitiligo. One hundred and forty-four patients between the ages of 3 and 48 years were divided into three groups: group A received oral compound glycyrrhizin (OCG); group B received UVB applications twice weekly, and group C received OCG+UVB. Read More

    Sunitinib in metastatic renal cell carcinoma (mRCC): a developing country experience. Do our patients behave differently than the Western patients?
    Int Urol Nephrol 2016 Nov 23;48(11):1811-1816. Epub 2016 Jul 23.
    Department of Medical Oncology, Sher-i-Kashmir Institute Of Medical Sciences (SKIMS), Srinagar, India.
    Background: Metastatic renal cell carcinoma (mRCC) has historically been refractory to cytotoxic and hormonal agents. IL-2 and IFN-α provide response in a minority of patients. Small molecule tyrosine kinase inhibitors and monoclonal antibodies have established a role in the setting of mRCC. Read More

    Systematic understanding the mechanisms of vitiligo pathogenesis and its treatment by Qubaibabuqi formula.
    J Ethnopharmacol 2016 Aug 2;190:272-87. Epub 2016 Jun 2.
    Center of Bioinformatics, College of Life Science, Northwest A & F University, Yangling, Shaanxi 712100, China. Electronic address:
    Ethnopharmacological Relevance: Vitiligo is a depigmentation disorder, which results in substantial cosmetic disfigurement and poses a detriment to patients' physical as well as mental. Now the molecular pathogenesis of vitiligo still remains unclear, which leads to a daunting challenge for vitiligo therapy in modern medicine. Herbal medicines, characterized by multi-compound and multi-target, have long been shown effective in treating vitiligo, but their molecular mechanisms of action also remain ambiguous. Read More

    Condylomata lata on the ankle: an unusual location.
    Dermatol Pract Concept 2016 Apr 30;6(2):49-51. Epub 2016 Apr 30.
    Department of Dermatology, Tokyo Woman's Medical University Medical Center East, Tokyo, Japan.
    A 43-year-old Japanese man presented with reddish nodules on the ankle. The nodules had a yellowish crust and eroded surface. Dermoscopy revealed red to milky-red globules at the periphery and some glomerular vessels in the center and a whitish-pink network, which corresponded to capillary dilatation in the papillary dermis and prominent acanthosis, respectively. Read More

    DYSKERATOSIS CONGENITA IN TWO ETHIOPIAN BROTHERS.
    Ethiop Med J 2015 Oct;53(4):215-21
    Dyskeratosis congenita (DKC) is a rare, progressive bone marrow failure syndrome that is characterized by the triad of reticulated skin pigmentation, nail dystrophy and oral leukoplakia. Current evidence indicates that DKC is a disease of defective telomere maintenance, ribosome deficiency and protein synthesis dysfunction. Mortality is often associated with bone marrow failure (BMF), development of malignancy and other multisystem complications of the disease. Read More

    Multiple osteoblastomas in a child with Cushing syndrome due to bilateral adrenal micronodular hyperplasias.
    Ann Pediatr Endocrinol Metab 2016 Mar 31;21(1):47-50. Epub 2016 Mar 31.
    Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea.
    Adrenocorticotropin-independent adrenal hyperplasias are rare diseases, which are classified into macronodular (>1 cm) and micronodular (≤1 cm) hyperplasia. Micronodular adrenal hyperplasia is subdivided into primary pigmented adrenocortical disease and a limited or nonpigmented form 'micronodular adrenocortical disease (MAD)', although considerable morphological and genetic overlap is observed between the 2 groups. We present an unusual case of a 44-month-old girl who was diagnosed with Cushing syndrome due to MAD. Read More

    Glutathione as a skin whitening agent: Facts, myths, evidence and controversies.
    Indian J Dermatol Venereol Leprol 2016 May-Jun;82(3):262-72
    Skinnocence: The Skin Clinic, Gurgaon, Haryana, India.
    Glutathione is a low molecular weight thiol-tripeptide that plays a prominent role in maintaining intracellular redox balance. In addition to its remarkable antioxidant properties, the discovery of its antimelanogenic properties has led to its promotion as a skin-lightening agent. It is widely used for this indication in some ethnic populations. Read More

    Low-dose oral isotretinoin therapy in lichen planus pigmentosus: an open-label non-randomized prospective pilot study.
    Int J Dermatol 2016 Sep 7;55(9):1048-54. Epub 2016 Apr 7.
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: Lichen planus pigmentosus (LPP) is a cosmetically distressing pigmentary disorder often posing a therapeutic challenge. Isotretinoin has been shown to be effective in oral and cutaneous LP, but its role in LPP is yet unknown.

    Objective: To evaluate the efficacy and safety of isotretinoin in the management of LPP. Read More

    HIV-Associated Oral Mucosal Melanin Hyperpigmentation: A Clinical Study in a South African Population Sample.
    AIDS Res Treat 2016 24;2016:8389214. Epub 2016 Feb 24.
    Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria 0204, South Africa.
    Objective. The aim of the study was to determine the prevalence of HIV-associated oral mucosal melanin hyperpigmentation (HIV-OMH) in a specific population of HIV-seropositive South Africans and to analyse the associations between HIV-OMH clinical features and the demographic and immunological characteristics of the study cohort. Material and Methods. Read More

    Three cases of pigmented cosmetic dermatitis-like eruptions associated with primary Sjögren's syndrome or anti-SSA antibody.
    J Dermatol 2016 Aug 19;43(8):947-50. Epub 2016 Feb 19.
    Department of Dermatology, Oita University, Kyoto, Japan.
    Pigmented cosmetic dermatitis-like (Riehl's melanosis-like) pigmentation was reported in three of 27 patients with primary Sjögren's syndrome. But case reports of such eruptions are rare. We describe three cases of such eruptions associated with primary Sjögren's syndrome or anti-SSA antibody and possible associations with specific types of human leukocyte antigen (HLA) and infiltrating lymphocytes. Read More

    The skin-depigmenting potential of Paeonia lactiflora root extract and paeoniflorin: in vitro evaluation using reconstructed pigmented human epidermis.
    Int J Cosmet Sci 2016 Oct 4;38(5):444-51. Epub 2016 Mar 4.
    L'Oréal Research and Innovation, 1 Avenue Eugène Schueller, 93601 Aulnay sous Bois, France.
    Objective: The roots of the herb Paeonia lactiflora ('White Peony') are used in association with other herbs in traditional clinical cosmetic practice in China as oral treatment for skin pigmentary disorders, such as brown or dark pigmentary spots. However, the skin-depigmenting potential of Paeonia lactiflora root extract and its main ingredient paeoniflorin has been scarcely investigated by topical application. The purpose of this study was to evaluate the efficacy of Paeonia lactiflora root extract and paeoniflorin as skin whitening agent in cosmetic application. Read More

    Erythrosis Pigmentosa Peribuccalis in an Adolescent: Dermoscopic Description and Management.
    Pediatr Dermatol 2016 Mar-Apr;33(2):e65-8. Epub 2016 Jan 29.
    Hospital Alemán, Buenos Aires, Argentina.
    Erythrosis pigmentosa peribuccalis is an infrequent condition, with fewer than 35 cases reported in the literature, that affects mainly women. It presents as small papules that form a hyperpigmented plaque around the mouth and nose. Little is known about the etiology of this condition, its dermoscopic characteristics have not been described, and no effective treatment has been reported. Read More

    Dyskeratosis congenita associated with leukoplakia of the tongue.
    Int J Oral Maxillofac Surg 2016 Jun 5;45(6):760-3. Epub 2016 Jan 5.
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan.
    Dyskeratosis congenita (DC) is an inherited disease characterized by the triad of skin pigmentation, nail dystrophy, and oral leukoplakia. Among other abnormalities, bone marrow failure and a predisposition to cancer are recognized as the major causes of premature mortality in patients with DC. This disease is associated with short telomeres and mutations in 10 genes associated with telomerase and telomere components. Read More

    The role of STK 11 gene testing in individuals with oral pigmentation.
    Australas J Dermatol 2017 May 14;58(2):135-138. Epub 2016 Jan 14.
    Royal Melbourne Hospital, Familial Cancer Centre, Melbourne, Victoria, Australia.
    Peutz-Jeghers syndrome (PJS) is a rare, autosomal dominant condition characterised by mucocutaneous pigmented lesions, gastrointestinal polyposis and a significant risk of cancer. Laugier-Hunziker syndrome (LHS) is a benign condition with similar dermatological features, but with no systemic complications. STK 11 gene testing allows clinicians to differentiate between these two disorders. Read More

    [Pathogenic and clinical presentation of bullous rash in hand, foot and mouth disease].
    Zhonghua Er Ke Za Zhi 2015 Aug;53(8):616-20
    Objective: To investigate the pathogenic and clinical presentation and laboratory tests of bullous rash in hand, foot and mouth disease (HFMD) in Xi'an from January 2013 to December 2014 by retrospective analysis.

    Method: A total of 224 specimens were collected from clinically diagnosed HFMD cases who were characterized by widespread mucocutaneous bullous reactions in Xi'an Children's Hospital from January 2013 to December 2014, the identification and subtyping of the isolates were conducted with real-time fluorescent quantitative RT-PCR. A retrospective analysis was performed to analyze the clinical presentation, laboratory tests and late follow-up problems of the HFMD. Read More

    Prevalence and clinical features of pigmented oral lesions.
    Int J Dermatol 2016 Sep 28;55(9):1005-13. Epub 2015 Dec 28.
    University College London, London, UK.
    Background: To examine the relative prevalence, types, and clinical features of pigmented lesions of the oral mucosa in 1275 patients attending a university hospital for dental care.

    Methods: Patients attending dental clinics at The University of Jordan Hospital over a 1-year period were examined for the presence of oral pigmentations. Histopathological examination was performed on focally pigmented lesions with a suspicious or uncertain clinical diagnosis. Read More

    Removal of black stains from teeth by photodynamic therapy: clinical and microbiological analysis.
    BMJ Case Rep 2015 Dec 23;2015. Epub 2015 Dec 23.
    Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
    Black-pigmented bacteria (BPB) are Gram-negative anaerobic, non-motile, proteolytic rods strongly implicated in the pathogenesis of periodontal disease. Although pigments are produced in vitro, black pigmentation is rarely found clinically. However, it may compromise aesthetics and contribute to gingival inflammation. Read More

    Discoloration of the Peri-implant Mucosa Caused by Zirconia and Titanium Implants.
    Int J Periodontics Restorative Dent 2016 Jan-Feb;36(1):39-45
    The aim of the present study was to assess the discoloration of the peri-implant mucosa caused by zirconia (Zr) and titanium (Ti) dental implants with and without soft tissue grafting (STG). Zr and Ti implants were inserted in edentulous areas in pig maxillae. Spectrophotometric measurements were performed prior to and after the insertion of the implants, and following the placement of a STG on the buccal side. Read More

    Safety of administering the canine melanoma DNA vaccine (Oncept) to cats with malignant melanoma - a retrospective study.
    J Feline Med Surg 2017 Feb 10;19(2):224-230. Epub 2016 Jul 10.
    3 VCA Clinical Studies, Bedford Hills, NY, USA.
    Objectives A xenogeneic human tyrosinase DNA vaccine was developed for treatment of dogs with oral malignant melanoma (Oncept; Merial). No studies have evaluated the safety or efficacy of this vaccine in cats. The purpose of this study was to evaluate the safety of the canine melanoma vaccine in cats diagnosed with melanoma. Read More

    The Smile Esthetic Index (SEI): A method to measure the esthetics of the smile. An intra-rater and inter-rater agreement study.
    Eur J Oral Implantol 2015 ;8(4):397-403
    Purpose: To propose a method to measure the esthetics of the smile and to report its validation by means of an intra-rater and inter-rater agreement analysis.

    Materials And Methods: Ten variables were chosen as determinants for the esthetics of a smile: smile line and facial midline, tooth alignment, tooth deformity, tooth dischromy, gingival dischromy, gingival recession, gingival excess, gingival scars and diastema/missing papillae. One examiner consecutively selected seventy smile pictures, which were in the frontal view. Read More

    Graphite oral tattoo: case report.
    Dermatol Online J 2015 Oct 16;21(10). Epub 2015 Oct 16.
    Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, Univ. Estadual Paulista-UNESP, São José dos Campos, São Paulo, Brazil.
    Pigmented oral lesions compose a large number of pathological entities, including exogenous pigmentat oral tattoos, such as amalgam and graphite tattoos. We report a rare case of a graphite tattoo on the palate of a 62-year-old patient with a history of pencil injury, compare it with amalgam tattoos, and determine the prevalence of oral tattoos in our Oral Pathology Service. We also compare the clinical and histological findings of grafite and amalgam tattoos. Read More

    Pharyngeal Presentation of Goltz Syndrome: A Case Report with Review of the Literature.
    Head Neck Pathol 2016 Jun 17;10(2):188-91. Epub 2015 Nov 17.
    Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, The Pennsylvania State University, College of Medicine, 500 University Drive, H091, Hershey, PA, 17033-0850, USA.
    Focal dermal hypoplasia (Goltz syndrome; GS) is an X-linked dominant disorder caused by a mutation in the porcupine homolog (PORCN) gene and is typically embryonically lethal for males. The presence of disease in males is usually the result of post-zygotic mutation, but may also be due to mosaicism. The presentation of this disorder is highly variable, but generally is characterized by cutaneous, skeletal, ocular, oral, dental, and aural defects. Read More

    Odontoiatric perspectives and osteonecrosis of the jaw as a possible adverse effect of bisphosphonates therapy in fibrous dysplasia and McCune-Albright syndrome.
    J Pediatr Endocrinol Metab 2016 Mar;29(3):333-6
    Background: McCune-Albright syndrome (MAS) is characterized by the triad of polyostotic bone fibrous dysplasia (PFD), endocrine disorders, and café-au-lait skin pigmentation. Ninety percent of MAS patients have fibrous dysplasia (FD) craniofacial lesions. Osteonecrosis of the jaw (ONJ) has been described as an adverse side effect of bisphosphonate therapy. Read More

    Macular pigmentation complicating irritant contact dermatitis and viral warts in Laugier-Hunziker syndrome.
    Clin Exp Dermatol 2016 Apr 28;41(3):294-6. Epub 2015 Oct 28.
    Department of Dermatology, Singleton Hospital, Swansea, UK.
    Laugier-Hunziker syndrome (LHS) is a rare acquired disorder characterized by macu-lar pigmentation of the lips and oral mucosa, with frequent longitudinal melanonychia. Involvement of other areas, such as the genitalia and fingers, has rarely been described. LHS is a benign condition with no known systemic manifestations. Read More

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