19,274 results match your criteria Disorders of Carbohydrate Metabolism


Effect of bile acid supplementation on endogenous lipid synthesis in patients with short bowel syndrome: A pilot study.

Clin Nutr 2019 Apr 2. Epub 2019 Apr 2.

Nutrition Intensive Care Unit, Hospices Civil de Lyon, F-69495, Pierre Benite Cedex, France. Electronic address:

Background & Aims: Short bowel syndrome patients (SBS) receiving parenteral nutrition (PN) often have dyslipidaemia and can develop intestinal failure-associated liver disease (IFALD). These patients demonstrate increased cholesterol synthesis and hepatic lipogenesis. These lipid disturbances may be due to a decreased concentration of the bile acid pool or malabsorption. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193015
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http://dx.doi.org/10.1016/j.clnu.2019.03.037DOI Listing
April 2019
1 Read

Multiplatform metabolomics provides insight into the molecular basis of chronic kidney disease.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 3;1117:49-57. Epub 2019 Apr 3.

Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gdańsk, Poland. Electronic address:

Changes in metabolites composition can reflect currently present pathological processes in a living organism and constitute a basis for diagnosis and treatment improvements. Thus, the multiplatform metabolomics approach was applied for the investigation of molecular mechanisms of chronic kidney disease (CKD) progression. The high-performance liquid chromatography coupled with time-of-flight mass spectrometry (HPLC-TOF-MS) and gas chromatography coupled with triple quadrupole mass spectrometry (GC-QqQ/MS) serum metabolic fingerprinting followed by uni- and multivariate statistical analysis was carried out to determine metabolic pattern differentiating CKD patients and healthy controls. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15700232183116
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http://dx.doi.org/10.1016/j.jchromb.2019.04.003DOI Listing
April 2019
1 Read

High intake of dietary fructose in overweight/obese teenagers associated with depletion of Eubacterium and Streptococcus in gut microbiome.

Gut Microbes 2019 Apr 16:1-8. Epub 2019 Apr 16.

a Department of Pediatrics, The Saban Research Institute, Children's Hospital Los Angeles , University of Southern California , Los Angeles , CA , USA.

Background: A western high fat, high carbohydrate diet has been shown to be associated with decreased gut bacterial diversity and reductions in beneficial bacteria. This gut bacteria dysbiosis could develop in early life and contribute to chronic disease risk such as obesity, type 2 diabetes and non-alcoholic fatty liver disease.

Objective: To determine how dietary macronutrients are associated with the relative abundance of gut bacteria in healthy adolescents. Read More

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https://www.tandfonline.com/doi/full/10.1080/19490976.2019.1
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http://dx.doi.org/10.1080/19490976.2019.1592420DOI Listing
April 2019
2 Reads

Dietary Macronutrient Management to Treat Mitochondrial Dysfunction in Parkinson's Disease.

Int J Mol Sci 2019 Apr 15;20(8). Epub 2019 Apr 15.

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

Mitochondrial dysfunction has been demonstrated to play an important role in the pathogenesis of Parkinson's disease (PD). The products of several PD-associated genes, including , , , , and , have important roles in mitochondrial biology. Thus, modifying mitochondrial function could be a potential therapeutic strategy for PD. Read More

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http://dx.doi.org/10.3390/ijms20081850DOI Listing
April 2019
1 Read

[Ghrelin Physiology and Pathophysiology: Focus on the Cardiovascular System].

Kardiologiia 2019 Apr 13;59(3):60-67. Epub 2019 Apr 13.

Research Institute for Complex Issues of Cardiovascular Diseases Kemerovo State Medical University.

Ghrelin is a multifunctional peptide hormone, mainly synthesized by P / D1 cells of the stomach fundus mucosa. Its basic effect, which is realized via GHS-R1 α receptor in the arcuate and the ventromedial nucleuses of hypothalamus, is stimulation of the synthesis of pituitary hormones. Ghrelin is involved in control of appetite and energy balance, regulation of carbohydrate and lipid metabolism, cell proliferation and apoptosis, as well as modulation of functioning of gastrointestinal, cardiovascular, pulmonary and immune systems. Read More

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https://lib.ossn.ru/jour/article/view/569
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http://dx.doi.org/10.18087/cardio.2019.3.10220DOI Listing
April 2019
2 Reads

Adipose tissue proteomic analysis in ketotic or healthy Holstein cows in early lactation.

J Anim Sci 2019 Apr 15. Epub 2019 Apr 15.

Key Laboratory of Zoonoses Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin, China.

Ketosis is a major metabolic disorder of high-yielding dairy cows during the transition period. Although metabolic adaptations of the adipose tissue are critical for a successful transition, beyond lipolysis, alterations within adipose tissue during ketosis are not well known. The objective of this study was to investigate the adipose tissue proteome of healthy or ketotic postpartum cows to gain insights into biological adaptations that may contribute to disease outcomes. Read More

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http://dx.doi.org/10.1093/jas/skz132DOI Listing
April 2019
1 Read
2.108 Impact Factor

Disruption of ESR1 alters the expression of genes regulating hepatic lipid and carbohydrate metabolism in male rats.

Mol Cell Endocrinol 2019 Apr 8. Epub 2019 Apr 8.

Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, 66160, USA; Institute for Reproduction and Perinatal Research, University of Kansas Medical Center, Kansas City, KS, 66160, USA. Electronic address:

The liver helps maintain energy homeostasis by synthesizing and storing glucose and lipids. Gonadal steroids, particularly estrogens, play an important role in regulating metabolism. As estrogens are considered female hormones, metabolic disorders related to the disruption of estrogen signaling have mostly been studied in females. Read More

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http://dx.doi.org/10.1016/j.mce.2019.04.005DOI Listing
April 2019
1 Read

Oxidative stress in lung cancer patients is associated with altered serum markers of lipid metabolism.

PLoS One 2019 11;14(4):e0215246. Epub 2019 Apr 11.

Department of Food Science and Dietetics, Wroclaw Medical University, Wroclaw, Poland.

In lung cancer (LC), alterations in redox balance are extensively observed and are a consequence of disease as well as co-occurrent with smoking. We previously demonstrated that metabolic disturbances such as trace element status and carbohydrate metabolism alterations are linked with redox status. The aim of this study was to evaluate relationships between the serum parameters of lipid metabolism and redox balance in LC patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215246PLOS
April 2019
1 Read

[INTERLEUKIN-1Β AND INTERLEUKIN-6 - A NEW MARKERS OF METABOLIC DISORDERS IN DIABETES MELLITUS TYPE 2].

Georgian Med News 2019 Feb(287):82-87

Kharkiv National Medical University, Ukraine.

A total of 102 patients with diabetes type 2 and no severe diabetic complications were examined in the endocrinology department of the Kharkiv Regional Clinical Hospital. The following data were analyzed: anthropometric measurements, indicators of carbohydrate and lipid metabolism, the level of activity of pro-inflammatory cytokines interleukin-1β and interleukin-6; as well as the intensity of cardiometabolic disorders, assessed by echocardiography. A statistical analysis revealed an increase of interleukin-1β and interleukin-6 activity, starting from the early stages of the disease, as well as the direct participation of these cytokines in the formation and progression of diabetic dyslipidemia and hyperinsulinemia, which allows us to consider them as the markers of metabolic disorders in patients with diabetes type 2. Read More

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February 2019

Menière's Disease and Disorders of the Carbohydrate Metabolism Involving the Inner Ear.

Int Arch Otorhinolaryngol 2019 Apr 15;23(2):218-220. Epub 2019 Feb 15.

Department of Otolaryngology, Hospital Albert Einstein, São Paulo, SP, Brazil.

 Menière's disease was described in 1861, but there are still uncertainties regarding its pathophysiology and treatment. Endolymphatic hydrops is recognized as a fundamental pathological characteristic of the disease, as a result of an inadequate absorption of the endolymph. A milder type of endolymphatic hydrops results from an altered chemical composition of the endolymph, due to disorders of the carbohydrate metabolism. Read More

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http://dx.doi.org/10.1055/s-0038-1673698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449135PMC

Low intake of digestible carbohydrates ameliorates duodenal absorption of carbohydrates in mice with glucose metabolism disorders induced by artificial sweeteners.

J Sci Food Agric 2019 Apr 5. Epub 2019 Apr 5.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, China.

Background: Long-term artificial sweetener consumption has been reported to induce glucose intolerance, and the intestinal microbiota seems as an important target. While the impacts of artificial sweeteners on energy balance remain controversial. This work aimed to evaluate the protective effects in mice of a low digestible carbohydrate (LDC) diet on plasma glucose, plasma fasting insulin, sweet taste receptors, glucose transporters, and absorption of carbohydrates, together with consumption of acesulfame potassium (AK) or saccharin (SAC). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jsfa.9727
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http://dx.doi.org/10.1002/jsfa.9727DOI Listing
April 2019
5 Reads

Snack selection influences glucose metabolism, antioxidant capacity and cholesterol in healthy overweight adults: A randomized parallel arm trial.

Nutr Res 2019 Mar 7. Epub 2019 Mar 7.

San Diego State University, Department of Exercise and Nutritional Sciences, 5500 Campanile Drive, San Diego, CA 92182. Electronic address:

Including carbohydrate/fructose-rich foods (predominantly fruit) in the diets of overweight individuals can improve chronic disease risk factors. We hypothesized dried plums (DP) would improve nutrient consumption, total antioxidant capacity (TAC), lipid and adipokine profiles, and would decrease adiposity and inflammation. To test this, we studied the effects of 8-weeks of twice-daily snacking of macronutrient-matched 100 kcal servings of DP or refined carbohydrate-rich snack (low-fat muffins: LFM) on daily energy and nutrient consumption, and chronic disease risk factors in overweight adults. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02715317193011
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http://dx.doi.org/10.1016/j.nutres.2019.03.002DOI Listing
March 2019
4 Reads

Transcriptome profiling of coriander: a dual purpose crop unravels stem gall resistance genes.

J Genet 2019 Mar;98(1)

ICAR-National Research Centre on Seed Spices, Tabiji, Ajmer 305 206, India.

Stem gall ( Unger), a serious disease that affects leaves, petioles, stems and fruits of coriander ( L.) causing heavy loss in yield. Genetic improvement of coriander for stem gall disease is indispensable. Read More

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Dietary unsaturated fat increases HDL metabolic pathways involving apoE favorable to reverse cholesterol transport.

JCI Insight 2019 Apr 4;4(7). Epub 2019 Apr 4.

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Background: HDL that contains apolipoprotein E (apoE) is a subspecies especially active in steps in reverse cholesterol transport, a process that brings cholesterol from peripheral cells to the liver. Here, we studied the effect of dietary unsaturated fat compared with carbohydrate on the metabolism of HDL containing apoE.

Methods: We enrolled 9 adults who were overweight or obese and had below-average HDL-cholesterol in a crossover study of a high-fat diet, primarily unsaturated, and a low-fat, high-carbohydrate diet. Read More

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http://dx.doi.org/10.1172/jci.insight.124620DOI Listing

Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells.

Nat Cell Biol 2019 04 1;21(4):498-510. Epub 2019 Apr 1.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Metabolic reprogramming is a hallmark of cancer. Here, we demonstrate that tumour-associated macrophages (TAMs) enhance the aerobic glycolysis and apoptotic resistance of breast cancer cells via the extracellular vesicle (EV) transmission of a myeloid-specific lncRNA, HIF-1α-stabilizing long noncoding RNA (HISLA). Mechanistically, HISLA blocks the interaction of PHD2 and HIF-1α to inhibit the hydroxylation and degradation of HIF-1α. Read More

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http://dx.doi.org/10.1038/s41556-019-0299-0DOI Listing

Direct association between high fat dietary pattern and risk of being in the higher stages of chronic kidney disease.

Int J Vitam Nutr Res 2019 Apr 1:1-10. Epub 2019 Apr 1.

3 Professor, Department of Community Nutrition, School of Nutritional sciences and dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Background: Although there are some reports on the association of dietary patterns and chronic kidney disease (CKD), no data exists regarding the relation between dietary pattern and CKD from developing countries.

Objective: To examine the association between major dietary patterns, renal function and progression of CKD.

Methods: Two hundred twenty one subjects with diagnosed CKD were selected for this cross-sectional study. Read More

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http://dx.doi.org/10.1024/0300-9831/a000260DOI Listing
April 2019
1 Read

[Elucidation of Disease Mechanisms Based on Transport Function at Tissue Barriers and Challenges in Drug Development].

Authors:
Shingo Ito

Yakugaku Zasshi 2019 ;139(4):497-503

Department of Pharmaceutical Microbiology, Faculty of Life Sciences, Kumamoto University.

Tissue barriers contribute to the maintenance of homeostasis in the body, and tissue barrier dysfunction presents a risk factor for a variety of diseases. The blood-brain barrier (BBB) is a major tissue barrier acting as a static barrier and dynamic interface that plays an important role in the maintenance of central nervous system homeostasis. We show the functional characterization of the brain-to-blood efflux transport system of amyloid-β peptide (Aβ) across the BBB. Read More

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http://dx.doi.org/10.1248/yakushi.18-00153DOI Listing
April 2019
5 Reads

Role of cadmium and arsenic as endocrine disruptors in the metabolism of carbohydrates: Inserting the association into perspectives.

Biomed Pharmacother 2019 Mar 25;114:108802. Epub 2019 Mar 25.

Institute of Pharmacy, Physiology and Pharmacy, University of Agriculture, Faisalabad, Pakistan. Electronic address:

Endocrine disrupting chemicals (EDCs) have widespread environmental distribution originated from both natural and anthropogenic sources. From the last few decades, their contamination has been raised dramatically owing to continuous discharge in sewage and untreated industrial effluents. They have rapidly gained a considerable attention due to their critical role in the development of multiple endocrine-related disorders notably diabetes mellitus (DM). Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108802DOI Listing
March 2019
2.023 Impact Factor

Life-style-induced metabolic derangement and epigenetic changes promote diabetes and oxidative stress leading to NASH and atherosclerosis severity.

J Diabetes Metab Disord 2018 Dec 29;17(2):381-391. Epub 2018 Nov 29.

Integrated Pharma Solutions, Philadelphia, PA USA.

Energy imbalance resulting from high calorie food intake and insufficient metabolic activity leads to increased body mass index (BMI) and sets the stage for metabolic derangement influencing lipid and carbohydrate metabolism and ultimately leading to insulin resistance, dyslipidemia, and type 2 diabetes. 70% of cardiovascular disease (CVD) deaths occur in patients with diabetes. Environment-induced physiological perturbations trigger epigenetic changes through chromatin modification and leads to type 2 diabetes and progression of nonalcoholic fatty liver disease (NAFLD) and CVD. Read More

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http://dx.doi.org/10.1007/s40200-018-0378-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405391PMC
December 2018

Correlation analysis between short-term insulin-like growth factor-I and glucose intolerance status after transsphenoidal adenomectomy in acromegalic patients: a large retrospective study from a single center in China.

Arch Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Department of Neurosurgery, Peking Union Medical College Hospital, Peking, China.

Objectives: Our study aimed to investigate the associations of glucose tolerance status with insulin-like growth factor-I (IGF-I) and other clinical laboratory parameters of acromegalic patients before and after the patients underwent transsphenoidal adenomectomy (TSA) by conducting a single-center, retrospective study.

Subjects And Methods: A total of 218 patients with acromegaly who had undergone TSA as the first treatment were retrospectively analyzed. Serum IGF-I, growth hormone (GH) and glucose levels were measured before and after surgery. Read More

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http://dx.doi.org/10.20945/2359-3997000000118DOI Listing
March 2019
1 Read

Effects of almond consumption on metabolic function and liver fat in overweight and obese adults with elevated fasting blood glucose: A randomised controlled trial.

Clin Nutr ESPEN 2019 Apr 11;30:10-18. Epub 2019 Jan 11.

Commonwealth Scientific and Industrial Research Organisation - Health and Biosecurity, Riverside Corporate Park, 11 Julius Avenue, North Ryde, 2113, Australia. Electronic address:

Background: Almonds are a rich source of bioactive components. This study examined the effects of daily almond consumption on glycaemic regulation, liver fat concentration and function, adiposity, systemic inflammation and cardiometabolic health.

Methods: 76 adults with elevated risk of type 2 diabetes (T2D) or T2D (age: 60. Read More

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http://dx.doi.org/10.1016/j.clnesp.2018.12.088DOI Listing
April 2019
2 Reads

Establishing a Link between Endothelial Cell Metabolism and Vascular Behaviour in a Type 1 Diabetes Mouse Model.

Cell Physiol Biochem 2019 ;52(3):503-516

Department of Biomedicine, Unit of Biochemistry, Faculty of Medicine of the University of Porto, Porto, Portugal.

Background/aims: Vascular complications contribute significantly to the extensive morbidity and mortality rates observed in people with diabetes. Despite well known that the diabetic kidney and heart exhibit imbalanced angiogenesis, the mechanisms implicated in this angiogenic paradox remain unknown. In this study, we examined the angiogenic and metabolic gene expression profile (GEP) of endothelial cells (ECs) isolated from a mouse model with type1 diabetes mellitus (T1DM). Read More

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http://dx.doi.org/10.33594/000000036DOI Listing
April 2019
2 Reads
2.875 Impact Factor

Reversible histone glycation is associated with disease-related changes in chromatin architecture.

Nat Commun 2019 03 20;10(1):1289. Epub 2019 Mar 20.

Chemical Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

Cellular proteins continuously undergo non-enzymatic covalent modifications (NECMs) that accumulate under normal physiological conditions and are stimulated by changes in the cellular microenvironment. Glycation, the hallmark of diabetes, is a prevalent NECM associated with an array of pathologies. Histone proteins are particularly susceptible to NECMs due to their long half-lives and nucleophilic disordered tails that undergo extensive regulatory modifications; however, histone NECMs remain poorly understood. Read More

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http://dx.doi.org/10.1038/s41467-019-09192-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426841PMC
March 2019
3 Reads

Clinical impact of citrate-containing tubes on the detection of glucose abnormalities by the oral glucose tolerance test.

Diagnosis (Berl) 2019 Mar 15. Epub 2019 Mar 15.

Clinical Laboratory, St. Bortolo Hospital, Vicenza, Italy.

Background Plasma glucose levels provide the cornerstone of diabetes evaluation, and so it is crucial that clinical laboratories provide accurate and reliable plasma glucose results. To prevent in vitro glycolysis, citrate is used. Here, we present the first study on the 75-g oral glucose tolerance test (OGTT) using the currently available new citrate-containing tubes in liquid and granular forms and the previous sodium fluoride (NaF) for the diagnosis of carbohydrate metabolism disorders and gestational diabetes mellitus (GDM) according to the American Diabetes Association (ADA) guidelines. Read More

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http://dx.doi.org/10.1515/dx-2018-0100DOI Listing
March 2019
1 Read

[Rare genetic markers of cognitive impairment in diabetes mellitus].

Zh Nevrol Psikhiatr Im S S Korsakova 2019;119(2):76-79

Siberian State Medical University.

The study of potential mechanisms of cognitive impairments associated with gene expression in patients with diabetes mellitus (DM) is becoming increasingly important due to the increase in the prevalence of dementia in this category of patients. DM is associated with the alteration of neurogenesis, and the variability of glycemia causes the changes in plasma and mitochondria, promotes the formation of free radicals, oxidative stress, activation of apoptosis of neurons, circulation of proinflammatory agents and other pathological factors. The association between diabetes and cognitive impairment is largely mediated by both neurodegeneration markers and cerebrovascular diseases. Read More

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http://dx.doi.org/10.17116/jnevro201911902176DOI Listing
January 2019
5 Reads

Subchronic low-dose 2,4-D exposure changed plasma acylcarnitine levels and induced gut microbiome perturbations in mice.

Sci Rep 2019 Mar 13;9(1):4363. Epub 2019 Mar 13.

Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

The gut microbiota critically confers various health benefits, whereas environmental chemicals can affect its constitution and functionality thereby increasing disease risk. In the present study, we aim to evaluate the toxic effects of a wildly-used herbicide 2,4-D (2,4-dichlorophenoxyacetic acid) on the gut microbiome and host using an occupationally relevant dose. A mouse model was used combined with metagenomic sequencing and metabolomic profiling to examine the alterations induced by subchronic low-dose 2,4-D exposure in fecal and plasma samples. Read More

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http://dx.doi.org/10.1038/s41598-019-40776-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416245PMC
March 2019
3 Reads

Preliminary Report on the Feasibility and Efficacy of the Modified Atkins Diet for Treatment of Mild Cognitive Impairment and Early Alzheimer's Disease.

J Alzheimers Dis 2019 ;68(3):969-981

Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Ketone bodies, the products of fat metabolism, are a source of energy for the brain and are available even when glucose supplies are inadequate (such as with severe carbohydrate deprivation) or its metabolism is faulty (as it is in Alzheimer's disease). This phase I/II randomized clinical trial examined the feasibility of using a modified Atkins diet (MAD) to induce ketogenesis in persons with mild cognitive impairment (MCI) or early AD, and the effect of this diet on memory and other clinical outcomes. In the first 2. Read More

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http://dx.doi.org/10.3233/JAD-180995DOI Listing
January 2019

FINDRISC Modified for Latin America As A Screening Tool For Persons With Impaired Glucose Metabolism In Ciudad Bolivar, Venezuela.

Med Princ Pract 2019 Mar 11. Epub 2019 Mar 11.

Objective: The Finnish Diabetes Risk Score (FINDRISC) includes anthropometric, metabolic, and lifestyle factors that predict type 2 diabetes mellitus (T2DM). The objective of this study was to evaluate the FINDRISC modified for Latin America (LA-FINDRISC) as a screening tool for persons with impaired glucose metabolism in Ciudad Bolívar - Venezuela.

Methods: Subjects aged between 18-70 years of both sexes without known diabetes were invited to participate. Read More

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http://dx.doi.org/10.1159/000499468DOI Listing

Characterizing the microbiota in gastrointestinal tract segments of Rhabdophis subminiatus: Dynamic changes and functional predictions.

Microbiologyopen 2019 Mar 7:e789. Epub 2019 Mar 7.

Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.

The gut microbiota helps the host to absorb nutrients and generate immune responses that can affect host behavior, development, reproduction, and overall health. However, in most of the previous studies, microbiota was sampled mainly using feces and intestinal contents from mammals but not from wild reptiles. Here, we described the bacterial profile from five different gastrointestinal tract (GIT) segments (esophagus, stomach, small intestine, large intestine, and cloaca) of three wild Rhabdophis subminiatus using 16S rRNA V4 hypervariable amplicon sequencing. Read More

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http://dx.doi.org/10.1002/mbo3.789DOI Listing
March 2019
3 Reads

Glycemic control and complications in glycogen storage disease type I: Results from the Swiss registry.

Mol Genet Metab 2019 Feb 28. Epub 2019 Feb 28.

Department of Endocrinology, Diabetes, and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland; radiz - Rare Disease Initiative Zurich, Clinical Research Priority Program for Rare Diseases, University of Zurich, Switzerland. Electronic address:

Background: Regular carbohydrate intake to avoid hypoglycemia is the mainstay of dietary treatment in glycogen storage disease type I (GSDI). The aim of this study was to evaluate the quality of dietary treatment and glycemic control in a cohort of GSDI patients, in relation to the presence of typical long-term complications.

Methods: Data of 25 patients (22 GSD subtype Ia and 3 GSDIb, median age 20y) from the Swiss hepatic glycogen storage disease registry was analyzed cross-sectionally. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10967192193003
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http://dx.doi.org/10.1016/j.ymgme.2019.02.008DOI Listing
February 2019
12 Reads

Assessing the effect of sugar type and form of its intake on selected parameters of carbohydrate-lipid metabolism and plasma atherogenic indices in rats

Rocz Panstw Zakl Hig 2019 ;70(1):59-67

West Pomeranian University of Technology in Szczecin, Faculty of Food Sciences and Fisheries, Department of Human Nutrition Physiology, al. Piastów 17, 70-310 Szczecin, Poland

Background: Over the past 50 years, the average consumption of sugar worldwide has tripled, also the type of consumed sugar has changed. Due to high price of sucrose and its technological disadvantages, high fructose corn syrup (HFCS) has become one of the most commonly used substitutes.

Objective: The aim of the study was to compare, on the animal model, the effect of sugar type (sucrose vs high fructose corn syrup 55% of fructose) and the sugar form (solid vs fluid and solid) on the chosen parameters of carbohydrate-lipid metabolism. Read More

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http://wydawnictwa.pzh.gov.pl/roczniki_pzh/pobierz-artykul?i
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http://dx.doi.org/10.32394/rpzh.2019.0055DOI Listing
January 2019
5 Reads

Hypoxia-Inducible Factors and the Regulation of Lipid Metabolism.

Cells 2019 Mar 3;8(3). Epub 2019 Mar 3.

Laboratory of Physiology, Faculty of Medicine, University of Thessaly, BIOPOLIS, 41500 Larissa, Greece.

Oxygen deprivation or hypoxia characterizes a number of serious pathological conditions and elicits a number of adaptive changes that are mainly mediated at the transcriptional level by the family of hypoxia-inducible factors (HIFs). The HIF target gene repertoire includes genes responsible for the regulation of metabolism, oxygen delivery and cell survival. Although the involvement of HIFs in the regulation of carbohydrate metabolism and the switch to anaerobic glycolysis under hypoxia is well established, their role in the control of lipid anabolism and catabolism remains still relatively obscure. Read More

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http://dx.doi.org/10.3390/cells8030214DOI Listing

Gene expression patterns indicate that a high-fat-high-carbohydrate diet causes mitochondrial dysfunction in fish.

Genome 2019 Feb 4;62(2):53-67. Epub 2019 Mar 4.

a College of Fisheries Huazhong Agricultural University, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Freshwater Aquaculture Collaborative Innovation Center of Hubei Province, Wuhan 430070, P.R. China.

Expensive and unsustainable fishmeal is increasingly being replaced with cheaper lipids and carbohydrates as sources of energy in aquaculture. Although it is known that the excess of lipids and carbohydrates has negative effects on nutrient utilization, growth, metabolic homeostasis, and health of fish, our current understanding of mechanisms behind these effects is limited. To improve the understanding of diet-induced metabolic disorders (both in fish and other vertebrates), we conducted an eight-week high-fat-high-carbohydrate diet feeding trial on blunt snout bream (Megalobrama amblycephala), and studied gene expression changes (transcriptome and qPCR) in the liver. Read More

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http://dx.doi.org/10.1139/gen-2018-0159DOI Listing
February 2019

RELATIONSHIP BETWEEN CARBOHYDRATE METABOLISM VALUES AND CALPROTECTIN LEVELS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION WITH REGARD TO CONCOMITANT TYPE 2 DIABETES MELLITUS.

Georgian Med News 2019 Jan(286):46-49

Kharkiv National Medical University, Department of Internal Medicine No.2; Clinical Immunology and Allergology named after academician L.T. Malaya, Ukraine.

According to literature, the presence of concomitant diabetes mellitus type 2 (DM) is associated with a high frequency of complications in patients with acute myocardial infarction (MI) due to the development of repeated episodes of myocardial ischemia, left ventricular dysfunction, life threatening rhythm disorders, and thromboembolic events Aim: to analyze the state of immuno-inflammation based on the study of calprotectin, as well as to assess the presence and nature of links with carbohydrate metabolism parameters based on the study of blood glucose, insulin and insulin resistance. Patients with AMI in combination with DM 2 were found to have a significant increase in the level of calprotectin by 25.9% (p<0. Read More

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January 2019
4 Reads

Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance.

Nat Commun 2019 03 1;10(1):991. Epub 2019 Mar 1.

State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031, Shanghai, China.

6-Phosphogluconate dehydrogenase (6PGD) is a key enzyme that converts 6-phosphogluconate into ribulose-5-phosphate with NADP as cofactor in the pentose phosphate pathway (PPP). 6PGD is commonly upregulated and plays important roles in many human cancers, while the mechanism underlying such roles of 6PGD remains elusive. Here we show that upon EGFR activation, 6PGD is phosphorylated at tyrosine (Y) 481 by Src family kinase Fyn. Read More

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http://dx.doi.org/10.1038/s41467-019-08921-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397164PMC

[Peculiarities the main types of metabolism of students of middle educational institutions depending on the organization of the educational process and public catering].

Vopr Pitan 2019 27;88(1):62-70. Epub 2018 Dec 27.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

Taking into account the fact that factors of intra-school environment are of great importance when forming health of pupils, this study aimed to investigate the main kinds of metabolism among pupils of secondary educational institutions depending on the organization of educational process and food services.

Material And Methods: The observing group comprised of 137 students of Secondary School focusing on physico-mathematical sciences at the age of 12.9±1. Read More

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http://dx.doi.org/10.24411/0042-8833-2019-10007DOI Listing
December 2018

Chlorogenic acid attenuates high-carbohydrate, high-fat diet-induced cardiovascular, liver, and metabolic changes in rats.

Nutr Res 2019 Feb 9;62:78-88. Epub 2018 Nov 9.

Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD 4350, Australia. Electronic address:

Chlorogenic acid as a constituent of coffee is consumed regularly in the human diet. Chlorogenic acid intake has been associated with decreased risk of cardiovascular disease and type 2 diabetes. We hypothesized that chlorogenic acid would improve cardiovascular, liver, and metabolic responses in a rat model of metabolic syndrome induced by a high-carbohydrate, high-fat diet. Read More

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http://dx.doi.org/10.1016/j.nutres.2018.11.002DOI Listing
February 2019
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Distinct Genetic and Functional Traits of Human Intestinal Prevotella copri Strains Are Associated with Different Habitual Diets.

Cell Host Microbe 2019 Mar 21;25(3):444-453.e3. Epub 2019 Feb 21.

Department of Agricultural Sciences, University of Naples Federico II, Portici, Italy; Task Force on Microbiome Studies, University of Naples Federico II, Naples, Italy. Electronic address:

The role of intestinal Prevotella species in human health is controversial, with both positive and negative associations. Strain-level diversity may contribute to discrepancies in genus and species associations with health and disease. We dissected the gut metagenomes of Italians with varying dietary habits, investigating the presence of distinct Prevotella copri strains. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19313128193004
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http://dx.doi.org/10.1016/j.chom.2019.01.004DOI Listing
March 2019
7 Reads

Superficial candidosis course in patients with carbohydrate metabolism disorder and diabetes mellitus.

Wiad Lek 2019;72(1):68-71

Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.

Objective: Introduction: One of the pressing issues of modern dermatology is the prevalence of diseases of skin and mucous membranes caused by yeast-like fungi. The aim: To study specific features of the course of skin and mucous membranes superficial candidosis against the background of initial carbohydrate metabolism disorders or diabetes mellitus.

Patients And Methods: Materials and methods: We have examined 93 patients aged 18-75 suffering from superficial candidosis. Read More

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January 2019
2 Reads

Comparative Proteomic Analysis of Wheat Carrying Response to f. sp. Using Two-Dimensional Electrophoresis.

Int J Mol Sci 2019 Feb 21;20(4). Epub 2019 Feb 21.

College of Agronomy & Key Laboratory for Major Crop Diseases, Sichuan Agricultural University, Chengdu 611130, China.

Wheat powdery mildew caused by f. sp. () is considered a major wheat leaf disease in the main wheat producing regions of the world. Read More

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http://dx.doi.org/10.3390/ijms20040933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412634PMC
February 2019
2 Reads

The potential contribution of impaired brain glucose metabolism to congenital Zika syndrome.

J Anat 2019 Feb 21. Epub 2019 Feb 21.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.

The Zika virus (ZIKV) became a major worldwide public concern in 2015 due to the congenital syndrome which presents the highest risk during the first trimester of pregnancy and includes microcephaly and eye malformations. Several cellular, genetic and molecular studies have shown alterations in metabolic pathways, endoplasmic reticulum (ER) stress, immunity and dysregulation of RNA and energy metabolism both in vivo and in vitro. Here we summarise the main metabolic complications, with a particular focus on the possibility that brain energy metabolism is altered following ZIKV infection, contributing to developmental abnormalities. Read More

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http://dx.doi.org/10.1111/joa.12959DOI Listing
February 2019
1 Read
2.097 Impact Factor

Clinical and biochemical characteristics of high-intensity functional training (HIFT) and overtraining syndrome: findings from the EROS study (The EROS-HIFT).

J Sports Sci 2019 Jun 20;37(11):1296-1307. Epub 2019 Feb 20.

a Adrenal and Hypertension Unit, Division of Endocrinology and Metabolism, Department of Medicine , Federal University of São Paulo Medical School , São Paulo , Brazil.

The metabolic and hormonal consequences of high-intensity functional training regimens such as CrossFit® (CF) are unclear. Little is known about the triggers and clinical and biochemical features of CF-related overtraining syndrome (OTS). The EROS study compared endocrine and metabolic responses, and eating, social, psychological and body characteristics of OTS-affected (OTS) and healthy athletes (ATL), and non-physically active controls (NPAC). Read More

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https://www.tandfonline.com/doi/full/10.1080/02640414.2018.1
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http://dx.doi.org/10.1080/02640414.2018.1555912DOI Listing
June 2019
5 Reads

Ambient fine particulate matter exposure induces cardiac functional injury and metabolite alterations in middle-aged female mice.

Environ Pollut 2019 Jan 30;248:121-132. Epub 2019 Jan 30.

College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi, 030006, PR China. Electronic address:

Plenty of epidemiological studies have shown that exposure to ambient particulate matter (PM) is linked to cardiovascular diseases (CVDs) in older even in middle-aged populations; however, experimental evidence through intuitive metabolic analysis to confirm the age susceptibility and explain the related molecular mechanism of PM-induced cardiotoxicity is relatively rare. In the present study, C57BL/6 mice (adult (4-month) and middle-aged (10-month)) were given 3 mg/kg PM every other day by oropharyngeal aspiration for 4 weeks, and then, body and cardiac parameter, containing weight data, cardiac function, ultrastructure, metabolic analysis, and molecular detection were conducted to investigate the PM-induced cardiotoxicity. The results indicated that middle-aged mice were more susceptible to PM, displaying slow cardiac growth, cardiac dysfunction, abnormal mitochondrial structure and function, and cardiac metabolic disorders. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.01.080DOI Listing
January 2019

Diet quality and eating patterns in euthymic bipolar patients.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1221-1238

Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznań, Poland.

Objective: As mood disorders and obesity are interrelated, and both are linked to increased morbidity and mortality, risk factors for obesity should be identified and closely monitored in patients with bipolar disorder (BD). The aim of this study was to determine the diet quality of BD patients and to investigate its putative associations with comorbid obesity and disorders of carbohydrate metabolism, as well as the relationship between diet and clinical features of BD.

Patients And Methods: Eating patterns in 113 euthymic BD patients and 160 healthy control subjects were assessed using data obtained from a food frequency questionnaire. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17016DOI Listing
February 2019

Chaperone Mediated Autophagy in the Crosstalk of Neurodegenerative Diseases and Metabolic Disorders.

Front Endocrinol (Lausanne) 2018 31;9:778. Epub 2019 Jan 31.

Dentistry Faculty, Institute in Dentistry Sciences, University of Chile, Santiago, Chile.

Chaperone Mediated Autophagy (CMA) is a lysosomal-dependent protein degradation pathway. At least 30% of cytosolic proteins can be degraded by this process. The two major protein players of CMA are LAMP-2A and HSC70. Read More

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http://dx.doi.org/10.3389/fendo.2018.00778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365421PMC
January 2019

Urine metabolic profiles in paediatric asthma.

Respirology 2019 Feb 14. Epub 2019 Feb 14.

Department of Paediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Background And Objective: Asthma is a global problem and complex disease suited for metabolomic profiling. This study explored the candidate biomarkers specific to paediatric asthma and provided insights into asthmatic pathophysiology.

Methods: Children (aged 6-11 years) meeting the criteria for healthy control (n = 29), uncontrolled asthma (n = 37) or controlled asthma (n = 43) were enrolled. Read More

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http://dx.doi.org/10.1111/resp.13479DOI Listing
February 2019
2 Reads

Macronutrients and the Adipose-Liver Axis in Obesity and Fatty Liver.

Cell Mol Gastroenterol Hepatol 2019 Feb 11;7(4):749-761. Epub 2019 Feb 11.

Department of Medicine and Liver Center, University of California, San Francisco, San Francisco, California.

Macronutrient metabolism is a highly orchestrated process, with adipose tissue and liver each playing central roles in nutrient uptake, processing, transport, and storage. These 2 tissues form an important metabolic circuit, particularly as it relates to lipids as the primary storage form of excess energy. The function of the circuit is influenced by many factors, including the quantity and type of nutrients consumed and their impact on the overall health of the tissues. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2019.02.001DOI Listing
February 2019
1 Read

[The prospective of using plant polyphenols as functional food ingredients].

Vopr Pitan 2018 13;87(6):57-66. Epub 2018 Nov 13.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

In this review we briefly discuss the publications dedicated to experimental evaluation of hypoglycemic, hypolipidemic and antioxidant properties of different plant polyphenols. The stages of preclinical studies of their efficacy are presented: in silico studies with molecular docking methods and in vivo studies with the use of genetic and medicamental models of type 2 diabetes. The results of own studies present the substantiation of prospects of using the plant polyphenol extracts as functional food ingredients for diet therapy and treatment of patients with type 2 diabetes. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10067DOI Listing
November 2018

Relationship between HbA1c and Lipid Profile Seen in Bangladeshi Type 2 Diabetes Mellitus Patients Attending BIRDEM Hospital: A Cross-Sectional Study.

Mymensingh Med J 2019 Jan;28(1):91-95

Dr Afsana Begum, Lecturer, Department of Biochemistry, Mugda Medical College (MuMC), Dhaka, Bangladesh; E-mail:

Diabetes mellitus is one of the leading non-communicable diseases all over the world including Bangladesh. Diabetes is characterized by chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. Glycated hemoglobin (HbA1c) level of ≥6. Read More

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January 2019

Two KTR Mannosyltransferases Are Responsible for the Biosynthesis of Cell Wall Mannans and Control Polarized Growth in .

MBio 2019 02 12;10(1). Epub 2019 Feb 12.

Aspergillus Unit, Institut Pasteur, Paris, France

Fungal cell wall mannans are complex carbohydrate polysaccharides with different structures in yeasts and molds. In contrast to yeasts, their biosynthetic pathway has been poorly investigated in filamentous fungi. In , the major mannan structure is a galactomannan that is cross-linked to the β-1,3-glucan-chitin cell wall core. Read More

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http://dx.doi.org/10.1128/mBio.02647-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372797PMC
February 2019
1 Read