24,693 results match your criteria Disorders of Carbohydrate Metabolism

[The negative impact of sleep disorders on working memory may be mediated by changes in carbohydrate metabolism].

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(5. Vyp. 2):11-17

Institute of Higher Nervous Activity and Neurophysiology, Moscow, Russia.

Sleep restriction and sleep disturbances are very common in modern industrialized societies, increasing the risk for the development of chronic sleep deficiency in the long term. Sleep disturbances are known to affect cognitive functions, primarily, working memory - the ability to store, update, and manipulate information over brief intervals for use in complex cognitive problems solving. However, the specific mechanisms underlying the decline in working memory due to disturbed sleep are still unclear. Read More

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January 2022

Helpful or harmful? The impact of the ketogenic diet on eating disorder outcomes in type 1 diabetes mellitus.

Expert Rev Endocrinol Metab 2022 Jun 24:1-13. Epub 2022 Jun 24.

Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK.

Introduction: Eating disorders (EDs) are common complications in people with type 1 diabetes (PwT1D), given the rigid focus on food and insulin dose adjustment. Dietary recommendations for T1D match those for the general population, yet many fail to achieve target HbA1c. Evidence suggests that lower carbohydrate meals and thus reduced insulin requirements may decrease inconsistencies in insulin absorption, maintain euglycemia and weight. Read More

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Genetic and Epigenetic Association of Hepatocyte Nuclear Factor-1α with Glycosylation in Post-Traumatic Stress Disorder.

Genes (Basel) 2022 Jun 14;13(6). Epub 2022 Jun 14.

Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Ruder Boskovic Institute, 10000 Zagreb, Croatia.

Post-traumatic stress disorder (PTSD) is a complex trauma-related disorder, the etiology and underlying molecular mechanisms of which are still unclear and probably involve different (epi)genetic and environmental factors. Protein N-glycosylation is a common post-translational modification that has been associated with several pathophysiological states, including inflammation and PTSD. Hepatocyte nuclear factor-1α (HNF1A) is a transcriptional regulator of many genes involved in the inflammatory processes, and it has been identified as master regulator of plasma protein glycosylation. Read More

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Urine Proteome in Distinguishing Hepatic Steatosis in Patients with Metabolic-Associated Fatty Liver Disease.

Diagnostics (Basel) 2022 Jun 7;12(6). Epub 2022 Jun 7.

Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu 610041, China.

Background: In patients with metabolic-associated fatty liver disease (MAFLD), hepatic steatosis is the first step of diagnosis, and it is a risk predictor that independently predicts insulin resistance, cardiovascular risk, and mortality. Urine biomarkers have the advantage of being less complex, with a lower dynamic range and fewer technical challenges, in comparison to blood biomarkers.

Methods: Hepatic steatosis was measured by magnetic resonance imaging (MRI), which measured the proton density fat fraction (MRI-PDFF). Read More

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Genetically Encoded ATP Biosensors for Direct Monitoring of Cellular ATP Dynamics.

Cells 2022 Jun 14;11(12). Epub 2022 Jun 14.

Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.

Adenosine 5'-triphosphate, or ATP, is the primary molecule for storing and transferring energy in cells. ATP is mainly produced via oxidative phosphorylation in mitochondria, and to a lesser extent, via glycolysis in the cytosol. In general, cytosolic glycolysis is the primary ATP producer in proliferative cells or cells subjected to hypoxia. Read More

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Imaging Neurodegenerative Metabolism in Amyotrophic Lateral Sclerosis with Hyperpolarized [1-C]pyruvate MRI.

Tomography 2022 Jun 14;8(3):1570-1577. Epub 2022 Jun 14.

Center of Functionally Integrative Neuroscience, Aarhus University, 8200 Aarhus, Denmark.

The cause of amyotrophic lateral sclerosis (ALS) is still unknown, and consequently, early diagnosis of the disease can be difficult and effective treatment is lacking. The pathology of ALS seems to involve specific disturbances in carbohydrate metabolism, which may be diagnostic and therapeutic targets. Magnetic resonance imaging (MRI) with hyperpolarized [1-C]pyruvate is emerging as a technology for the evaluation of pathway-specific changes in the brain's metabolism. Read More

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Tumor Microenvironment: Lactic Acid Promotes Tumor Development.

J Immunol Res 2022 12;2022:3119375. Epub 2022 Jun 12.

Department of Laboratory Medicine, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.

Lactic acid is a "metabolic waste" product of glycolysis that is produced in the body. However, the role of lactic acid in the development of human malignancies has gained increasing interest lately as a multifunctional small molecule chemical. There is evidence that tumor cells may create a large amount of lactic acid through glycolysis even when they have abundant oxygen. Read More

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Cellular metabolism in pancreatic cancer as a tool for prognosis and treatment (Review).

Int J Oncol 2022 Aug 22;61(2). Epub 2022 Jun 22.

Department of Biochemistry, Cell and Molecular Biology, Third Faculty of Medicine, Charles University, 10000 Prague, Czech Republic.

Pancreatic cancer (PC) has one of the highest fatality rates and the currently available therapeutic options are not sufficient to improve its overall poor prognosis. In addition to insufficient effectiveness of anticancer treatments, the lack of clear early symptoms and early metastatic spread maintain the PC survival rates at a low level. Metabolic reprogramming is among the hallmarks of cancer and could be exploited for the diagnosis and treatment of PC. Read More

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The gut metagenomics and metabolomics signature in patients with inflammatory bowel disease.

Gut Pathog 2022 Jun 21;14(1):26. Epub 2022 Jun 21.

Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu, People's Republic of China.

Inflammatory bowel disease (IBD), a chronic gut immune dysregulation and dysbiosis condition is rapidly increasing in global incidence. Regardless, there is a lack of ideal diagnostic markers, while conventional treatment provides scarce desired results, thus, the exploration for better options. Changes in the gut microbial composition and metabolites either lead to or are caused by the immune dysregulation that characterizes IBD. Read More

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Polymalic acid for translational nanomedicine.

J Nanobiotechnology 2022 Jun 21;20(1):295. Epub 2022 Jun 21.

Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu, China.

With rich carboxyl groups in the side chain, biodegradable polymalic acid (PMLA) is an ideal delivery platform for multifunctional purposes, including imaging diagnosis and targeting therapy. This polymeric material can be obtained via chemical synthesis, or biological production where L-malic acids are polymerized in the presence of PMLA synthetase inside a variety of microorganisms. Fermentative methods have been employed to produce PMLAs from biological sources, and analytical assessments have been established to characterize this natural biopolymer. Read More

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Presence of rare potential pathogenic variants in subjects under 65 years old with very severe or fatal COVID-19.

Sci Rep 2022 Jun 20;12(1):10369. Epub 2022 Jun 20.

Department of Genetics & Genomics, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Madrid, Spain.

Rare variants affecting host defense against pathogens could be involved in COVID-19 severity and may help explain fatal outcomes in young and middle-aged patients. Our aim was to report the presence of rare genetic variants in certain genes, by using whole exome sequencing, in a selected group of COVID-19 patients under 65 years who required intubation or resulting in death (n = 44). To this end, different etiopathogenic mechanisms were explored using gene prioritization-based analysis in which genes involved in immune response, immunodeficiencies or blood coagulation were studied. Read More

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Insight into the microbial mechanisms for the improvement of composting efficiency driven by Aneurinibacillus sp. LD3.

Bioresour Technol 2022 Jun 17;359:127487. Epub 2022 Jun 17.

School of Minerals Processing and Bioengineering, Central South University, Changsha 410083, China; Key Laboratory of Biometallurgy, Ministry of Education, Changsha 410083, China. Electronic address:

This work explored the microbial mechanisms for the improvement of composting efficiency driven by thermotolerant lignin-degrading bacterium Aneurinibacillus sp. LD3 (LD3). Results showed that LD3 inoculant prolonged the thermophilic period by 4 days, improved the final content of humic acid, total phosphorus (TP), nitrogen, potassium and seed germination index. Read More

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Obese Individuals With and Without Phlegm-Dampness Constitution Show Different Gut Microbial Composition Associated With Risk of Metabolic Disorders.

Front Cell Infect Microbiol 2022 1;12:859708. Epub 2022 Jun 1.

National Institute of Traditional Chinese Medicine Constitution and Preventive Treatment of Diseases, Beijing University of Chinese Medicine, Beijing, China.

Background: Obesity is conventionally considered a risk factor for multiple metabolic diseases, such as dyslipidemia, type 2 diabetes, hypertension, and cardiovascular disease (CVD). However, not every obese patient will progress to metabolic disease. Phlegm-dampness constitution (PDC), one of the nine TCM constitutions, is considered a high-risk factor for obesity and its complications. Read More

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Predictive value of baseline metabolic tumor volume in early-stage favorable Hodgkin Lymphoma - Data from the prospective, multicenter phase III HD16 trial.

BMC Cancer 2022 Jun 18;22(1):672. Epub 2022 Jun 18.

Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Straße 62, 50937, Cologne, Germany.

Background: F -fluorodeoxyglucose (FDG) positron emission tomography (PET) plays an important role in the staging and response assessment of lymphoma patients. Our aim was to explore the predictive relevance of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in patients with early stage Hodgkin lymphoma treated within the German Hodgkin Study Group HD16 trial.

Methods: F-FDG PET/CT images were available for MTV and TLG analysis in 107 cases from the HD16 trial. Read More

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PET-CTBased Quantitative Parameters for Assessment of Treatment Response and Disease Activity in Cancer and Noncancerous Disorders.

PET Clin 2022 Jul;17(3):465-478

Radiation Medicine Centre (BARC), Tata Memorial Hospital Annexe, Parel, Mumbai, India; Homi Bhabha National Institute, Mumbai, India. Electronic address:

The various semiquantitative and quantitative PET-CT parameters provide measurement of disease activity and assessment of treatment response in the PET-CT studies. These include standardized uptake value (SUV), metabolic tumor volume (MTV) and total lesion glycolysis (TLG), and total metabolic tumor volume (TMTV). Thresholding and adaptive thresholding methods are commonly used algorithms for the evaluation of global disease activity. Read More

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Effects of transdermal versus oral hormone replacement therapy in postmenopause: a systematic review.

Arch Gynecol Obstet 2022 Jun 17. Epub 2022 Jun 17.

Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, Verona, Italy.

Purpose: To summarize available evidence comparing the transdermal and the oral administration routes of hormone replacement therapy (HRT) in postmenopausal women.

Methods: We performed a systematic review of the literature on multiple databases between January 1990 and December 2021. We included randomized controlled trials and observational studies comparing the transdermal and oral administration routes of estrogens for HRT in postmenopausal women regarding at least one of the outcomes of interest: cardiovascular risk, venous thromboembolism (VTE), lipid metabolism, carbohydrate metabolism, bone mineral density (BMD), and risk of pre-malignant and malignant endometrial lesions, or breast cancer. Read More

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A novel photosynthetic biologic topical gel for enhanced localized hyperoxygenation augments wound healing in peripheral artery disease.

Sci Rep 2022 Jun 15;12(1):10028. Epub 2022 Jun 15.

Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.

Peripheral artery disease and the associated ischemic wounds are substantial causes of global morbidity and mortality, affecting over 200 million people worldwide. Although advancements have been made in preventive, pharmacologic, and surgical strategies to treat this disease, ischemic wounds, a consequence of end-stage peripheral artery disease, remain a significant clinical and economic challenge. Synechococcus elongatus is a cyanobacterium that grows photoautotrophically and converts carbon dioxide and water into oxygen. Read More

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Partial Remission of Diabetes in a Young Adult While Testing Positive for Several Islet Cell Autoantibodies: A Case Report, Literature Review, and Patient Perspective.

Samson O Oyibo

Cureus 2022 Jun 8;14(6):e25746. Epub 2022 Jun 8.

Diabetes and Endocrinology, Peterborough City Hospital, Peterborough, GBR.

Type 1 diabetes is a chronic disease characterized by abnormal metabolism and hyperglycemia due to insulin deficiency. There is a rapid decline in insulin production due to autoimmune destruction of the pancreatic beta cells. Partial remission (honeymoon phase) of type 1 diabetes is common in children and young adults with newly diagnosed type 1 diabetes. Read More

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Blood-based untargeted metabolomics in relapsing-remitting multiple sclerosis revealed the testable therapeutic target.

Proc Natl Acad Sci U S A 2022 Jun 14;119(25):e2123265119. Epub 2022 Jun 14.

Department of Neurology, Henry Ford Health System, Detroit, MI 48202.

Metabolic aberrations impact the pathogenesis of multiple sclerosis (MS) and possibly can provide clues for new treatment strategies. Using untargeted metabolomics, we measured serum metabolites from 35 patients with relapsing-remitting multiple sclerosis (RRMS) and 14 healthy age-matched controls. Of 632 known metabolites detected, 60 were significantly altered in RRMS. Read More

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Myeloid FoxO1 depletion attenuates hepatic inflammation and prevents nonalcoholic steatohepatitis.

J Clin Invest 2022 Jun 14. Epub 2022 Jun 14.

Department of Pediatrics, Children's Hospital, University of Pittsburgh School of Medicine, Pittsburgh, United States of America.

Hepatic inflammation is culpable for the evolution of asymptomatic steatosis to nonalcoholic steatohepatitis (NASH). Hepatic inflammation results from abnormal macrophage activation. We found that FoxO1 links overnutrition to hepatic inflammation by regulating macrophage polarization and activation. Read More

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Carbulin: A Comprehensive Mobile Application for Advanced Carbohydrate Counting and Diet- and Insulin-Regimen Planning for Type 1 Diabetic Patients.

J Biomed Phys Eng 2022 Jun 1;12(3):319-324. Epub 2022 Jun 1.

PhD, Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Nowadays, the introduction of the so-called 'diabetes technology', either hardware/device or software, to different aspects of day-to-day living in patients with diabetes aims to improve blood glucose control and various lifestyle features. The coordination of vast context of diabetes education/training, particularly in the area of medical nutrition therapy, is considered as a great concern. On the other hand, Iranian food culture consists of a set of traditional dietary patterns and food consumption habit. Read More

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Regulation of photosynthetic light reaction proteins via reversible phosphorylation.

Plant Sci 2022 Aug 13;321:111312. Epub 2022 May 13.

National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi 110067, India. Electronic address:

The regulation of photosynthesis occurs at different levels including the control of nuclear and plastid genes transcription, RNA processing and translation, protein translocation, assemblies and their post translational modifications. Out of all these, post translational modification enables rapid response of plants towards changing environmental conditions. Among all post-translational modifications, reversible phosphorylation is known to play a crucial role in the regulation of light reaction of photosynthesis. Read More

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iProtGly-SS: A Tool to Accurately Predict Protein Glycation Site Using Structural-Based Features.

Methods Mol Biol 2022 ;2499:125-134

Department of Computer Science and Engineering, United International University, Dhaka, Bangladesh.

Posttranslational modification (PTM) is an important biological mechanism to promote functional diversity among the proteins. So far, a wide range of PTMs has been identified. Among them, glycation is considered as one of the most important PTMs. Read More

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Comprehensive Assessment of Functional Effects of Commonly Used Sugar Substitute Sweeteners on Human Gut Microbiome.

Microbiol Spectr 2022 Jun 13:e0041222. Epub 2022 Jun 13.

School of Pharmaceutical Sciences, Faculty of Medicine, University of Ottawagrid.28046.38, Ottawa, Ontario, Canada.

The composition and function of the human gut microbiome are often associated with health and disease status. Sugar substitute sweeteners are widely used food additives, although many studies using animal models have linked sweetener consumption to gut microbial changes and health issues. Whether sugar substitute sweeteners directly change the human gut microbiome functionality remains largely unknown. Read More

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Antigen glycosylation regulates efficacy of CAR T cells targeting CD19.

Nat Commun 2022 Jun 11;13(1):3367. Epub 2022 Jun 11.

Division of Oncology, Washington University School of Medicine, Saint Louis, MO, USA.

While chimeric antigen receptor (CAR) T cells targeting CD19 can cure a subset of patients with B cell malignancies, most patients treated will not achieve durable remission. Identification of the mechanisms leading to failure is essential to broadening the efficacy of this promising platform. Several studies have demonstrated that disruption of CD19 genes and transcripts can lead to disease relapse after initial response; however, few other tumor-intrinsic drivers of CAR T cell failure have been reported. Read More

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Contribution of Metabolic Tumor Volume and Total Lesion Glycolysis to Predict Prognosis in Early-Stage Lung Cancer at Preoperative Staging.

J Coll Physicians Surg Pak 2022 Jun;32(6):740-745

Department of Thoracic Surgery, Recep Tayyip Erdogan University Education and Research Hospital, Rize, Turkey.

Objective: To evaluate the effect of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) values of the primary tumor measured by preoperative positron emission tomography/computed tomography (FDG-PET/CT) on survival in patients with operated non-small cell lung cancer (NSCLC).

Study Design: Cohort study.

Place And Duration Of Study: Recep Tayyip Erdogan University, Faculty of Medicine, Department of Medical Oncology from January 2017 to June 2020, Turkey. Read More

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Diet and Pediatric Functional Gastrointestinal Disorders in Mediterranean Countries.

Nutrients 2022 Jun 2;14(11). Epub 2022 Jun 2.

Department of Translational Medical Science, Section of Pediatrics, University of Naples "Federico II", 80138 Naples, Italy.

Background: The increased intake of FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides, and polyol) rich foods has been suggested as a possible trigger of functional gastrointestinal disorders (FGIDs). Despite the high FODMAP content, the Mediterranean diet (MD) appears to have beneficial effects on health. Our aim was to evaluate whether the prevalence of FGIDs in different Mediterranean countries may be influenced by FODMAP consumption and adherence to the MD. Read More

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Sedoheptulose Kinase SHPK Expression in Glioblastoma: Emerging Role of the Nonoxidative Pentose Phosphate Pathway in Tumor Proliferation.

Int J Mol Sci 2022 May 26;23(11). Epub 2022 May 26.

Fondazione Pisana per la Scienza, 56017 Pisa, Italy.

Glioblastoma (GBM) is the most common form of malignant brain cancer and is considered the deadliest human cancer. Because of poor outcomes in this disease, there is an urgent need for progress in understanding the molecular mechanisms of GBM therapeutic resistance, as well as novel and innovative therapies for cancer prevention and treatment. The pentose phosphate pathway (PPP) is a metabolic pathway complementary to glycolysis, and several PPP enzymes have already been demonstrated as potential targets in cancer therapy. Read More

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A Community-Led Approach as a Guide to Overcome Challenges for Therapy Research in Congenital Disorders of Glycosylation.

Int J Environ Res Public Health 2022 06 2;19(11). Epub 2022 Jun 2.

CDG & Allies-Professionals and Patient Associations International Network (CDG & Allies-PPAIN), Department of Life Sciences, School of Science and Technology, NOVA University Lisbon, 2819-516 Caparica, Portugal.

Congenital Disorders of Glycosylation (CDG) are a large family of rare genetic diseases for which effective therapies are almost nonexistent. To better understand the reasons behind this, to analyze ongoing therapy research and development (R&D) for CDG, and to provide future guidance, a community-led mixed methods approach was organized during the 4th World Conference on CDG for Families and Professionals. In the quantitative phase, electronic surveys pointed to the prioritization of six therapeutic R&D tools, namely biobanks, registries, biomarkers, disease models, natural history studies, and clinical trials. Read More

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-GlcNAcylation: The Underestimated Emerging Regulators of Skeletal Muscle Physiology.

Cells 2022 05 30;11(11). Epub 2022 May 30.

National Experimental Teaching Demonstration Center of Animal Medicine Foundation, College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China.

-GlcNAcylation is a highly dynamic, reversible and atypical glycosylation that regulates the activity, biological function, stability, sublocation and interaction of target proteins. -GlcNAcylation receives and coordinates different signal inputs as an intracellular integrator similar to the nutrient sensor and stress receptor, which target multiple substrates with spatio-temporal analysis specifically to maintain cellular homeostasis and normal physiological functions. Our review gives a brief description of -GlcNAcylation and its only two processing enzymes and HBP flux, which will help to better understand its physiological characteristics of sensing nutrition and environmental cues. Read More

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