Search Our Scientific Publications & Authors

J Chiropr Med 2022 Mar 9;21(1):60-65. Epub 2022 Jun 9.

Surgery, Midwest Spine & Brain Institute, Minneapolis, Minnesota.

Objective: The purpose of this case study is to describe chiropractic care of the cervical spine for a patient who previously underwent cervical total disk replacement (CTDR) of the C5-6 and C6-7 disks.

Clinical Features: A 42-year-old female veteran of the U.S. Read More

Front Endocrinol (Lausanne) 2022 6;13:890371. Epub 2022 Jun 6.

Department of Spinal Surgery, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China.

Aim: Accurate severity grading of lumbar spine disease by magnetic resonance images (MRIs) plays an important role in selecting appropriate treatment for the disease. However, interpreting these complex MRIs is a repetitive and time-consuming workload for clinicians, especially radiologists. Here, we aim to develop a multi-task classification model based on artificial intelligence for automated grading of lumbar disc herniation (LDH), lumbar central canal stenosis (LCCS) and lumbar nerve roots compression (LNRC) at lumbar axial MRIs. Read More

Oper Neurosurg (Hagerstown) 2022 Jul 20;23(1):60-66. Epub 2022 Apr 20.

Department of Neurological Surgery, New York-Presbyterian Hospital/Weill Cornell Medicine, New York, New York, USA.

Background: Disk herniations that obstruct the spinal canal by more than 50% are named "giant disk herniations" (GDHs). GDHs are challenging to treat from a surgical perspective because of their size and the risk of iatrogenic manipulation during resection resulting in additional neurological compromise. As a result, the appropriateness of minimally invasive tubular approaches for the treatment of lumbar GDHs remains controversial. Read More

Comput Intell Neurosci 2022 27;2022:3688630. Epub 2022 May 27.

Department of Medical Administration, Shandong Provincial Third Hospital, Jinan 250031, Shandong, China.

The aim of this study was to explore the application effect of computed tomography (CT) image based on active contour segmentation algorithm in the treatment of lumbar disc herniation (LDH) with scalpel. 78 patients with LDH were selected and divided into a lateral crypt block treatment group (group A) and a scalpel treatment group (group B) randomly. All the patients were examined by lumbar CT images based on artificial intelligence (AI) algorithm. Read More

Eur J Med Res 2022 Jun 3;27(1):82. Epub 2022 Jun 3.

Cervicodynia/Omalgia/Lumbago/Sciatica Department 2, Sichuan Province Orthopedic Hospital, 132 West First Section First Ring Road, Chengdu, 610041, Sichuan, China.

Background: Lumbar disc herniation (LDH) is not a common condition in children. Most reports on pediatric LDH concern the outcomes of surgeries performed in children in whom nonsurgical treatment failed while the outcome of nonsurgical treatment of LDH in children was rarely reported.

Cases Presentation: Case 1: a 10-year-old girl presented with back pain and sciatica in her left leg for over 3 months. Read More

Khirurgiia (Mosk) 2022 (6):72-79

Irkutsk Research Center of Surgery and Traumatology, Irkutsk, Russia.

Objective: To develop a new validated classification of intervertebral disc degeneration.

Material And Methods: A retrospective observational single-center study included medical records of patients with and without degenerative disease of lumbar intervertebral discs. The interval values of apparent diffusion coefficient (ADC) of intervertebral discs were grouped into degeneration classes. Read More

Semin Musculoskelet Radiol 2022 Jun 2;26(3):314-328. Epub 2022 Jun 2.

Department of Musculoskeletal Radiology, Hôpital Cochin, AP-HP Centre, Université de Paris, Paris, France.

Management of patients after lumbar spine surgery or interventional radiology can be complex, and postoperative imaging patterns are often poorly understood by nonspecialized radiologists. This article focuses on postoperative imaging features of the lumbar spine in five clinical settings (with corresponding interventions): vertebral osteoporotic fractures (percutaneous vertebroplasty and vertebral augmentation), lumbar disk herniation (surgical diskectomy and percutaneous interventional radiology), lumbar spinal stenosis (surgical decompression), lumbar spondylolisthesis (surgical decompression and fusion), and degenerative scoliosis (techniques of osteotomies).For each intervention, we discuss imaging indications, depending if the patient is asymptomatic or if there are suspected complications, describe normal and pathologic imaging features, and present key points. Read More

Bone Joint J 2022 Jun;104-B(6):715-720

Department of Neuroscience, Leeds General Infirmary, Leeds, UK.

Aims: The aim of the study was to determine if there was a direct correlation between the pain and disability experienced by patients and size of their disc prolapse, measured by the disc's cross-sectional area on T2 axial MRI scans.

Methods: Patients were asked to prospectively complete visual analogue scale (VAS) and Oswestry Disability Index (ODI) scores on the day of their MRI scan. All patients with primary disc herniation were included. Read More

BMC Musculoskelet Disord 2022 May 30;23(1):509. Epub 2022 May 30.

Department of Orthopedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China.

Background: Low back pain (LBP) is associated with lumbar disc degeneration (LDD) and fatty infiltration of paraspinal muscles. However, there are some controversies about the relationship between LDD and fatty infiltration of paraspinal muscles, and the causation of them is also not clear. Thus, we investigated whether the degree of LDD was associated with fatty infiltration of paraspinal muscles and preliminarily explored the underlying mechanism. Read More

Medicine (Baltimore) 2022 May 27;101(21):e29423. Epub 2022 May 27.

Department of Neurosurgery, Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea.

Rationale: Oblique lumbar interbody fusion (OLIF) is an effective and safe surgical technique widely used for treating spondylolisthesis; however, its use is controversial because of several associated complications, including endplate injury. We report a rare vertebral body fracture following OLIF in a patient with poor bone quality.

Patient Concerns: A 72-year-old male patient visited our clinic for 2 years with lower back pain, leg radiating pain, and intermittent neurogenic claudication. Read More

Neural Plast 2022 14;2022:7912410. Epub 2022 May 14.

Department of Orthopedics, Renhe Hospital, Baoshan District, Shanghai 200431, China.

Lumbar disc herniation (LDH) induced nerve compression syndromes have been a prevalent problem with complex neural mechanisms. Changes in distributed brain areas are involved in the occurrence and persistence of syndromes. The present study aimed to investigate the changes of brain functional network in LDH patients with chronic sciatica using graph theory analysis. Read More

J Clin Neurosci 2022 Jul 18;101:162-167. Epub 2022 May 18.

Department of Neurosurgery, University of Health Sciences Turkey, Prof. Dr. Cemil Taşçıoğlu City Hospital, Turkey. Electronic address:

Background/aim: Sleep deprivation may lead to individual and social insufficiency associated with many physiological and psychological pathologies. This study is reported to investigate sleep quality and the relationship between treatment modalities of lumbar disc herniation, which is the most common cause of chronic lower back pain and sciatica.

Materials And Methods: This present study was conducted on 249 cases with chronic lower back pain and sciatica caused by a single- level lumbar disc herniation diagnosed after lumbar MRI (Magnetic Resonance Imaging) between June 2017 and September 2019. Read More

Sci Rep 2022 May 18;12(1):8314. Epub 2022 May 18.

Faculty of Surgery, Ha Noi Medical University, 1 Ton That Tung Str., Dong Da, Ha Noi, Viet Nam.

The aim of the article is to present the first experience of applying a full-endoscopic posterior cervical foraminotomy and discectomy performed at Viet Duc University Hospital in Hanoi and describe the outcomes of such surgical intervention. This surgical series includes 20 patients underwent surgery through full-endoscopic posterior cervical foraminotomy and discectomy. The definitive diagnosis of the patients and the evidence for surgical treatment was radiculopathy due to lateral or intraforaminal disk herniation, foraminal stenosis, and lateral recess stenosis. Read More

Int J Environ Res Public Health 2022 05 7;19(9). Epub 2022 May 7.

Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.

Background: The aim of our observational study is to compare the therapeutic efficacy of combined treatment of oxygen-ozone therapy and oral treatment with alpha-lipoic acid (ALA) + palmitoylethanolamide (PEA) and myrrh in patients with peripheral neuropathic pain (sciatica) on radicular disc conflict from disc herniation and the results obtained with oxygen-ozone treatment alone.

Methods: We enrolled 318 patients with the neuroradiological diagnosis of disc herniation performed with computed tomography (CT) or magnetic resonance imaging (MRI) and symptoms characterized by low back pain complicated by sciatica, which we divided into two groups. Group A was composed of 165 patients who were treated only with oxygen-ozone therapy with CT-guided intraforaminal technique, while the remaining 153 (Group B) have undergone combined oral treatment with ALA + PEA and myrrh. Read More

PLoS One 2022 13;17(5):e0267384. Epub 2022 May 13.

Novosibirsk State University, Novosibirsk, Russia.

Lumbar intervertebral disc degeneration (DD) disease is one of the main risk factors for low back pain and a leading cause of population absenteeism and disability worldwide. Despite a variety of biological studies, lumbar DD is not yet fully understood, partially because there are only few studies that use systematic and integrative approaches. This urges the need for studies that integrate different omics (including genomics and transcriptomics) measured on samples within a single cohort. Read More

World Neurosurg 2022 Apr 30;164:118-127. Epub 2022 Apr 30.

Department of Spine Surgery, Indian Spinal Injuries Centre, New Delhi, India.

Objective: This case series looks at the role of intraoperative ultrasound in spine surgery for extradural pathologies.

Methods: Ten cases of different pathologies were included. Following posterior laminectomy, intraoperative ultrasound was used to determine the adequacy of decompression. Read More

J Vet Intern Med 2022 May 28;36(3):1049-1056. Epub 2022 Apr 28.

Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, New York, USA.

Background: Hydromyelia is a common magnetic resonance imaging (MRI) finding associated with compressive myelopathy caused by intervertebral disc extrusion (IVDE).

Objectives: To describe the MRI features of hydromyelia and explore its relationship to clinical history, neurological severity, and the duration of cord compression.

Animals: Ninety-one client-owned dogs with a focal compressive myelopathy secondary to thoracolumbar IVDE. Read More

Am J Case Rep 2022 Apr 27;23:e935208. Epub 2022 Apr 27.

Continuing Medical Education, Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, Colombia.

BACKGROUND The intervertebral disc extrusion resorption has been described in the literature by various authors. It occurs in up to 75% of patients with symptomatic extruded lumbar discs. The Atlasprofilax method favors osteo-musculo-articular rehabilitation processes, mainly impacting on 2 levels: the first is the bone anatomy of the atlanto-occipital joint, and the second is the fasciae located in the cervical region. Read More

Orthop Surg 2022 May 21;14(5):892-901. Epub 2022 Apr 21.

Department of Orthopaedics, The Fourth Medical Center, Chinese PLA General Hospital, Beijing, China.

Objective: To compare the efficacy and safety of retaining the posterior longitudinal ligament (PLL) with resecting the PLL in inside-out percutaneous endoscopic transforaminal discectomy (PETD) surgery for lumbar disc herniation (LDH).

Method: A total of 135 patients with symptomatic LDH who were treated by inside-out PETD surgery from January 2015 to January 2017were included in this retrospective analysis. There were 38 males and 30 females in the PLL resection group (mean age = 52. Read More

Int J Artif Organs 2022 May 20;45(5):478-487. Epub 2022 Apr 20.

Departments of Spine Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Purpose: To evaluate the biomechanics effect of modified cortical bone screw technique (MCBT) with other traditional internal fixation systems on lumbar osteoporotic wet specimen.

Methods: Four different finite element models were established using CT data: (1) lumbar osteoporosis model without internal fixation system; (2) traditional pedicle screw technology (TT) model; (3) traditional cortical bone screw technology (CBT) model; (4) MCBT model. The changes of global displacement, intervertebral disc displacement of all models and internal fixation system Von Mises stress among the three models were compared under the same physiological load. Read More

World J Clin Cases 2022 Mar;10(9):2883-2894

Department of Spine Surgery, The 940 Hospital of Joint Logistics Support force of Chinese People's Liberation, Lanzhou 730050, Gansu Province, China.

Background: Disc herniation refers to the displacement of disc material beyond its anatomical space. Disc sequestration is defined as migration of the herniated disc fragment into the epidural space, completely separating it from the parent disc. The fragment can move in upward, inferior, and lateral directions, which often causes low back pain and discomfort, abnormal sensation, and movement of lower limbs. Read More

J Clin Neurosci 2022 Jun 12;100:66-74. Epub 2022 Apr 12.

Bahçeşehir University, School of Medicine, Department of Physical Medicine and Rehabilitation, Istanbul, Turkey.

Schmorl's nodes (SNs) have increasingly been recognized on vertebral end-plates using advanced imaging techniques. Even though vertebral end-plates are the closest structures to discs, their pathologies are underestimated in the etiology of low back pain (LBP). We aimed to detect the prevalence of SNs and other end-plate defects in subjects with/without LBP and to understand whether SNs were associated with LBP and spinal degeneration. Read More

Stem Cells Transl Med 2022 05;11(5):490-503

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People's Republic of China.

The treatment of intervertebral disc degeneration (IVDD) is still a huge challenge for clinical updated surgical techniques and basic strategies of intervertebral disc regeneration. Few studies have ever tried to combine surgery and cell therapy to bridge the gap between clinical and basic research. A prospective clinical study with a 72-month follow-up was conducted to assess the safety and feasibility of autologous discogenic cells transplantation combined with discectomy in the treatment of lumbar disc herniation (LDH) and to evaluate the regenerative ability of discogenic cells in IVDD. Read More

Oper Neurosurg (Hagerstown) 2022 05;22(5):e221

Division of Physical Medicine and Rehabilitation, Department of Orthopedics and Rehabilitation, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.

Zh Vopr Neirokhir Im N N Burdenko 2022 ;86(2):109-118

Sklifosovsky Research Institute for Emergency Care, Moscow, Russia.

One of the most common causes of radiculopathy requiring neurosurgical treatment is a herniated disc. Magnetic resonance imaging (MRI) is still the main diagnostic approach for this lesion. However, MRI does not allow assessing the functional state of the root. Read More

Neurol Sci 2022 Jul 8;43(7):4167-4173. Epub 2022 Apr 8.

Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico C. Besta, University of Milan, Via Giovanni Celoria 11, 20133, Milan, Italy.

Background And Purpose: Intradural disc herniation (IDH) can manifest with radicular or medullary syndrome. In about 15% of cases, IDH may be responsible, through a dural laceration, for a CSF leak, determining spontaneous intracranial hypotension (SIH) and CNS superficial siderosis (CNSss). This paper attempts to present an overview on IDH as the cause for both CSF leak, and subsequent SIH, and CNSss, and to describe a peculiar clinical and neuroradiological scenario related to this condition. Read More

J Clin Neurosci 2022 Jun 4;100:37-45. Epub 2022 Apr 4.

A.U.O. "Policlinico Umberto I" - Neurosurgery Division - Sapienza University - Rome - Human Neurosciences Department - Via del Policlinico, 155 - 00161 Roma, Italy.

Purpose: Giant thoracic disc herniations (GTDH) are considered a subgroup of TDHs with worse functional outcomes, a high calcification rate, and a considerable risk of complications. We aimed to determine whether there is a relationship between the extent of calcification of GTDH and outcomes concerning the risk of complications, the surgical technique, and changes in neuromonitoring signals.

Methods: We present a retrospective analysis of 76 patients undergoing surgery for calcific GTDH. Read More

J Orthop Surg Res 2022 Apr 4;17(1):203. Epub 2022 Apr 4.

Spine Surgery Department 1, The Third Hospital of Hebei Medical University, Shijiazhuang, China.

Background: The fusion of the lumbar spine may lead to the degeneration of the adjacent segments. In this study, the effects of OLIF and TLIF on adjacent segments after treatment of L4 degenerative lumbar spondylolisthesis (DLS) were compared and analysed.

Methods: This was a retrospective analysis of the medical records of consecutive patients treated with OLIF or TLIF for L4DLS. Read More

Eur Rev Med Pharmacol Sci 2022 03;26(6):1923-1929

Department of Radiology, Inonu University, Faculty of Medicine, Malatya, Turkey.

Objective: The aim of this study was to compare preoperative and postoperative findings of the sciatic nerve by using B-mode ultrasound, strain elastography (SE), and shear wave elastography (SWE) in patients with unilateral lumbar foraminal disc herniation.

Patients And Methods: In this prospective study group, patients with complaints of foraminal disc herniation due to one level (L4-5 or L5-S1) were included. Preoperative and postoperative (one month after surgery) B-mode ultrasound, SE, and SWE findings of the affected sciatic nerve in patients who underwent unilateral spinal decompression surgery were compared. Read More

Eur J Pain 2022 Jul 12;26(6):1269-1281. Epub 2022 Apr 12.

Division of Spine Surgery, Department of Orthopedics, Rambam Health Care Campus, Haifa, Israel.

Background: Painful lumbar radiculopathy is a neuropathic pain condition, commonly attributed to nerve root inflammation/compression by disc herniation. The present exploratory study searched for associations between pain intensity and inflammatory markers, herniated disc size, infection, psychological factors and pain modulation in patients with confirmed painful lumbar radiculopathy scheduled for spine surgery.

Methods: Prior to surgery, 53 patients underwent the following evaluation: pain intensity measured on a 0-10 numeric rating scale (NRS) and the Short-Form McGill Pain Questionnaire; sensory testing (modified DFNS protocol); pain processing including temporal summation and conditioned pain modulation (CPM); neurological examination; psychological assessment including Spielberger's Anxiety Inventory, Pain Sensitivity Questionnaire and the Pain Catastrophizing Scale. Read More