2,347 results match your criteria Diseases of the Esophagus [Journal]


Routine placement of feeding jejunostomy tube during esophagectomy increases postoperative complications and does not improve postoperative malnutrition.

Dis Esophagus 2019 Apr 17. Epub 2019 Apr 17.

Division of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo, Japan.

Esophagectomy for esophageal cancer is a highly invasive procedure, and a feeding jejunostomy tube (FJT) is routinely placed to ensure adequate enteral nutrition. However, the effect of perioperative short-term FJT placement remains controversial, and the aim of this study was to assess risks and benefits of routine FJT placement during esophagectomy and to determine parameters that can identify patients needing long-term FJT. This retrospective study included 393 patients who had undergone esophagectomy with gastric tube reconstruction via the posterior mediastinal route at the Kobe University Hospital and the Hyogo Cancer Center between April 2010 and December 2017. Read More

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http://dx.doi.org/10.1093/dote/doz021DOI Listing
April 2019
1 Read

How many lymph nodes should be dissected in esophagectomy with or without neoadjuvant therapy to get accurate staging?

Dis Esophagus 2019 Apr 17. Epub 2019 Apr 17.

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

It is essential to dissect an adequate number of lymph nodes (LNs) to ensure staging accuracy during esophagectomy with or without neoadjuvant therapy. We developed a statistical model to quantify the probability of precise nodal staging based on previous studies. Esophageal cancer patients who underwent esophagectomy were retrospectively reviewed in the Surveillance, Epidemiology, and End Results database. Read More

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http://dx.doi.org/10.1093/dote/doz009DOI Listing

Shorter time to achieve endoscopic eradication is not associated with improved long-term outcomes in Barrett's esophagus.

Dis Esophagus 2019 Apr 17. Epub 2019 Apr 17.

Department of Medicine, Columbia University Medical Center, New York, USA.

Quality indicators have been proposed for endoscopic eradication therapy of Barrett's esophagus (BE). One such measure suggests that complete eradication of intestinal metaplasia (CE-IM) should be achieved within 18 months of starting treatment. The aim of this study was to assess whether achievement of CE-IM within 18 months is associated with improved long-term clinical outcomes. Read More

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http://dx.doi.org/10.1093/dote/doz026DOI Listing

Effective treatment improves the body composition of patients with esophageal motility disorders.

Dis Esophagus 2019 Apr 12. Epub 2019 Apr 12.

Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, and.

Although treatment for esophageal motility disorder improves dysphagia and increases body weight, the effect of the treatment on body composition is unclear. This study aimed to assess the change in body composition between before and after treatment, the preoperative predictors of muscle increase, and the association between muscle increase and quality of life. Sixty-one patients (achalasia, n = 55; spastic esophageal disorder n = 6) who underwent per-oral endoscopic myotomy were analyzed in a single-arm prospective observational study. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doz022DOI Listing
April 2019
2 Reads

Innovative fully robotic 4-arm Ivor Lewis esophagectomy for esophageal cancer (RAMIE4).

Dis Esophagus 2019 Apr 12. Epub 2019 Apr 12.

Department of General, Visceral and Transplant Surgery, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Nowadays robotic surgery is established for abdominal and thoracic surgery. It has been shown that complex procedures are feasible using robotic systems, e.g. Read More

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http://dx.doi.org/10.1093/dote/doz015DOI Listing
April 2019
1 Read

Comparison of long-term outcomes between esophagectomy and chemoradiotherapy after endoscopic resection of submucosal esophageal squamous cell carcinoma.

Dis Esophagus 2019 Apr 12. Epub 2019 Apr 12.

Department of Gastroenterological Surgery.

Esophagectomy represents the standard treatment strategy for superficial esophageal cancer diagnosed pathologically as submucosal disease (pT1b) following an endoscopic resection (ER). However, chemoradiotherapy (CRT) is expected to become an alternative treatment option. This study retrospectively compared the outcomes of patients who underwent ER of submucosal esophageal squamous cell carcinoma, and who received additional treatment in the form of surgery and CRT. Read More

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http://dx.doi.org/10.1093/dote/doz023DOI Listing
April 2019
1 Read

Study protocol for a multicenter prospective cohort study on esophagogastric anastomoses and anastomotic leak (the Oesophago-Gastric Anastomosis Audit/OGAA).

Dis Esophagus 2019 Mar 19. Epub 2019 Mar 19.

Academic Department of Surgery.

Esophagectomy is a mainstay in curative treatment for esophageal cancer; however, the reported techniques and outcomes can vary greatly. Thirty-day mortality of patients with an intact anastomosis is 2-3% as compared to 17-35% in patients who have an anastomotic leak. The subsequent management of leaks postesophagectomy has great global variability with little consensus on a gold standard of practice. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doz007DOI Listing
March 2019
6 Reads

Should endoscopic mucosal resection be attempted for cT2N0 esophageal cancer?

Dis Esophagus 2019 Mar 19. Epub 2019 Mar 19.

Department of Thoracic and Cardiovascular Surgery.

Endoscopic mucosal resection (EMR) can be an effective therapy for superficial esophageal cancer. Many patients with cT2 invasion by endoscopic ultrasound (EUS) receive surgery but are subsequently found to have superficial disease. The purpose of this study was to investigate the safety profile and the added value of attempting EMR for EUS-staged cT2N0 esophageal cancer. Read More

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http://dx.doi.org/10.1093/dote/doz016DOI Listing
March 2019
1 Read

Genetic variants in Barrett's esophagus and esophageal adenocarcinoma: a literature review.

Dis Esophagus 2019 Mar 19. Epub 2019 Mar 19.

Department of General Surgery, NorthShore University HealthSystem.

Surveillance of Barrett's esophagus (BE) is a clinical challenge; metaplasia of the distal esophagus increases a patient's risk of esophageal adenocarcinoma (EAC) significantly but the actual percentage of patients who progress is low. The current screening recommendations require frequent endoscopy and biopsy, which has inherent risk, high cost, and operator variation. Identifying BE patients genetically who are at high risk of progressing could deemphasize the role of endoscopic screening and create an opportunity for early therapeutic intervention. Read More

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http://dx.doi.org/10.1093/dote/doz017DOI Listing
March 2019
2.057 Impact Factor

What is the best method for calculating the optimal position of an esophageal pH probe in children?

Dis Esophagus 2019 Mar 19. Epub 2019 Mar 19.

Department of Pediatric Gastroenterology, Hepatology and Nutrition, Sant Joan de Déu Hospital, Barcelona, Catalonia, Spain.

In assessment of distal esophageal pH, the sensor of the probe should be placed above the upper border of the lower esophageal sphincter. There are several methods to estimate the distance from the nose where the probe should be fixed according to the patient's height. We studied the accuracy of these methods. Read More

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http://dx.doi.org/10.1093/dote/doz014DOI Listing

The prevalence and role of coping strategies in the nutritional intake of children born with esophageal atresia: a condition-specific approach.

Dis Esophagus 2019 Mar 19. Epub 2019 Mar 19.

Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

This study describes results of a condition-specific approach to the assessment of coping strategies in nutritional intake situations used by children with esophageal atresia. One hundred three families of children 2-17 years old with esophageal atresia participated (94% response rate). Following standardized focus groups with 30 families, nine coping items were developed, reflecting nine different coping strategies in nutritional intake situations. Read More

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http://dx.doi.org/10.1093/dote/doz004DOI Listing

Factors associated with overall survival and relief of dysphagia in advanced esophageal cancer patients after 125I seed-loaded stent placement: a multicenter retrospective analysis.

Dis Esophagus 2019 Mar 19. Epub 2019 Mar 19.

Center of Interventional Radiology and Vascular Surgery, Department of Radiology.

Iodine-125 (125I) seed-loaded stent placement has served as an effective palliation for malignant esophageal strictures in China. We performed a retrospective study to identify the prognostic factors of this irradiation stent placement in advanced esophageal cancer patients. A total of 201 patients who underwent 125I seed-loaded stent placement were included in this study from June 2012 to March 2016 at five hospitals in China. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doz012DOI Listing
March 2019
7 Reads

Prognostic impact of lymphovascular invasion in lymph node-negative superficial esophageal squamous cell carcinoma.

Dis Esophagus 2019 Mar 18. Epub 2019 Mar 18.

Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan.

The relationship between lymphovascular invasion (LVI) and prognosis in patients with superficial esophageal squamous cell carcinoma (SESCC) is unclear. The aim of this study is to evaluate prognostic factors in patients with lymph node-negative SESCC. A total of 195 patients with pathologically confirmed T1a-MM, T1b, and lymph node-negative SESCC were retrospectively reviewed in this study. Read More

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http://dx.doi.org/10.1093/dote/doz001DOI Listing

Randomized phase II trial comparing tumor bed alone with tumor bed and elective nodal postoperative radiotherapy in patients with locoregionally advanced thoracic esophageal squamous cell carcinoma.

Dis Esophagus 2019 Mar 11. Epub 2019 Mar 11.

Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University.

This study compares the outcomes of different postoperative radiation fields for locoregionally advanced thoracic esophageal squamous cell carcinoma (ESCC) patients. This is a multi-institution randomized phase II trial and noninferior study. Patients with ESCC who had undergone esophagectomy (stage T3-4N0-3M0) were enrolled and randomized into the large-field irradiation arm (LFI; tumor bed and elective lymph node region) and small-field irradiation arm (SFI; tumor bed only). Read More

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http://dx.doi.org/10.1093/dote/doz013DOI Listing
March 2019
7 Reads

Utility of routine oral contrast study for detecting postesophagectomy anastomotic leak - a systematic review and meta-analysis.

Dis Esophagus 2019 Mar 11. Epub 2019 Mar 11.

Division of Cancer Surgery, Peter MacCallum Cancer Centre (Victorian Comprehensive Cancer Centre).

Oral contrast studies are used to detect anastomotic leak (AL) postesophagectomy. However, recent evidence suggests oral contrast studies have low sensitivity in detecting ALs, and their false positive results can lead to unnecessary prolonged hospital stay. The objective of this study was to determine if oral contrast studies should be used routinely post-esophagectomy for cancer. Read More

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http://dx.doi.org/10.1093/dote/doz011DOI Listing

Preoperative esophageal stenting and short-term outcomes of surgery for esophageal cancer in a population-based study from Finland and Sweden.

Dis Esophagus 2019 Mar 11. Epub 2019 Mar 11.

Department of Surgery, Central Finland Central Hospital, Jyväskylä.

Population-based studies examining whether preoperative esophageal stenting influences the short-term outcomes after esophagectomy for esophageal cancer are lacking. This nationwide cohort combining data from Finland and Sweden was conducted to cover this gap. Patients with locally advanced esophageal cancer (T ≥ 3 and/or N ≥ 1, M0) who underwent esophagectomy between 2007 and 2014 were identified from nationwide registries in Finland and Sweden. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doz005DOI Listing
March 2019
5 Reads

Food impaction: etiology over 35 years and association with eosinophilic esophagitis.

Dis Esophagus 2019 Apr;32(4)

Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1093/dote/doz010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437261PMC

Can we perform esophagectomy for esophageal cancer patients with concomitant liver cirrhosis? A comprehensive systematic review and meta-analysis.

Dis Esophagus 2019 Mar 4. Epub 2019 Mar 4.

Lung Cancer Center, West China Hospital, Sichuan University, Chengdu.

Liver cirrhosis is sometimes encountered in esophageal cancer patients intended for surgery. However, the impact of liver cirrhosis on patients with surgically treated esophageal cancer remains unclear. Therefore, we conducted the first meta-analysis focusing on current topic. Read More

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http://dx.doi.org/10.1093/dote/doz003DOI Listing
March 2019
1 Read

Management of esophageal atresia and early predictive factors of mortality and morbidity in a developing country.

Dis Esophagus 2019 Mar 4. Epub 2019 Mar 4.

Pediatric Surgery Department, Hedi Chaker Hospital, Sfax, Tunisia.

The aim of this study is to investigate management and outcome in esophageal atresia (EA) and to identify early predictive factors of morbidity and mortality in a developing country. Charts of neonates with repaired EA from 2007 to 2016 were reviewed. Patients' characteristics, operative details, and postoperative outcomes were collected. Read More

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http://dx.doi.org/10.1093/dote/doy135DOI Listing
March 2019
2 Reads

Twenty-four hour pH score is still useful after 45 years.

Authors:
T R DeMeester

Dis Esophagus 2019 Mar 4. Epub 2019 Mar 4.

Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1093/dote/doy134DOI Listing

Stenosis of the celiac trunk is associated with anastomotic leak after Ivor-Lewis esophagectomy.

Dis Esophagus 2019 Mar 1. Epub 2019 Mar 1.

Department of General, Visceral and Cancer Surgery, University of Cologne, Germany.

Transthoracic esophagectomy with gastric tube formation is the surgical treatment of choice for esophageal cancer. The surgical reconstruction induces changes of gastric microcirculation, which are recognized as potential risk factors of anastomotic leak. This prospective observational study investigates the association of celiac trunk (TC) stenosis with postoperative anastomotic leak. Read More

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http://dx.doi.org/10.1093/dote/doy107DOI Listing

Delays in referral from primary care are associated with a worse survival in patients with esophagogastric cancer.

Dis Esophagus 2019 Mar 1. Epub 2019 Mar 1.

Department of Surgery and Cancer, St Mary's Hospital Campus.

NICE referral guidelines for suspected cancer were introduced to improve prognosis by reducing referral delays. However, over 20% of patients with esophagogastric cancer experience three or more consultations before referral. In this retrospective cohort study, we hypothesize that such a delay is associated with a worse survival compared with patients referred earlier. Read More

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http://dx.doi.org/10.1093/dote/doy132DOI Listing

Incidence and risk factors for esophageal cancer following achalasia treatment: national population-based case-control study.

Dis Esophagus 2019 Feb 27. Epub 2019 Feb 27.

Department Surgery & Cancer, Imperial College London, London.

The objective of this study is to identify the incidence of and risk factors associated with the development of esophageal cancer in treated achalasia patients in a national cohort. Patients with esophageal achalasia diagnosed and receiving a treatment between 2002 and 2012 were identified in England. Patient and treatment factors were compared between individuals who developed esophageal cancer and those that did not using univariate and multivariate analyses. Read More

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http://dx.doi.org/10.1093/dote/doy106DOI Listing
February 2019

Prognostic significance of sarcopenia in patients undergoing esophagectomy for superficial esophageal squamous cell carcinoma.

Dis Esophagus 2019 Feb 27. Epub 2019 Feb 27.

Department of Gastroenterological Surgery, Tokai University School of Medicine, Kanagawa, Japan.

Nononcological prognostic factors in superficial esophageal squamous cell carcinoma (SESCC) patients remain unclear. The aim of this study is to evaluate the relationship between sarcopenia and surgical outcome in patients with SESCC who had undergone definitive surgery. A total of 194 SESCC patients who had undergone thoracic esophagectomy with three-field lymphadenectomy without neoadjuvant therapy at Tokai University Hospital between January 2006 and December 2015 were analyzed retrospectively. Read More

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http://dx.doi.org/10.1093/dote/doy104DOI Listing
February 2019

Comparison of mediastinal lymph node metastases from adenocarcinoma of the esophagogastric junction versus lower esophageal squamous cell carcinoma with involvement of the esophagogastric junction.

Dis Esophagus 2019 Feb 22. Epub 2019 Feb 22.

Clinical Trial Planning and Management, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Ariake, Koto-ku, Tokyo, Japan.

The distribution of mediastinal lymph node metastasis in patients with adenocarcinoma of the esophagogastric junction (AEG) remains unclear. Additionally, the distribution of nodal mediastinal metastasis from squamous cell carcinoma (SCC) of the lower esophagus with involvement of the esophagogastric junction remains unclear, given the very limited number of these patients. In this retrospective review, we compared the outcomes of radical lymphadenectomy of the mediastinum, including upper mediastinal lymphadenectomy, between patients with AEG and those with SCC. Read More

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http://dx.doi.org/10.1093/dote/doz002DOI Listing
February 2019

Intraluminal mesh erosion after prosthetic hiatoplasty: incidence, management, and outcomes.

Dis Esophagus 2019 Feb 22. Epub 2019 Feb 22.

Department of Surgery Hospital Clínico San Carlos, Madrid, Spain.

The purpose of the present study was to analyze the incidence, presentation, and treatment of mesh erosion into the esophagus or stomach after mesh hiatoplasty for primary or recurrent hiatal hernia. The study is a single-institution, retrospective cohort study. From November 2005 to December 2016, 122 patients consecutively underwent mesh hiatoplasty in our department, 91 during a primary surgery and 31 for a surgical revision. Read More

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http://dx.doi.org/10.1093/dote/doy131DOI Listing
February 2019
3 Reads

Liquid Nitrogen Spray Cryotherapy in Treatment of Barrett's Esophagus, where do we stand? A Systematic Review and Meta-Analysis.

Dis Esophagus 2019 Jan 31. Epub 2019 Jan 31.

Division of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, Utah, USA.

Radiofrequency ablation (RFA) is the preferred treatment option for Barrett's esophagus (BE) to achieve complete eradication (CE) of dysplasia (D), and intestinal metaplasia (IM). Cryotherapy, using liquid nitrogen (LNC), is a cold-induced tissue-injury technique option for the ablation of BE. We conducted a systematic review and meta-analysis to assess the overall efficacy and safety of LNC in the treatment of BE. Read More

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http://dx.doi.org/10.1093/dote/doy130DOI Listing
January 2019
1 Read

Management of eosinophilic esophagitis is often discordant with guidelines and not patient-centered: results of a survey of gastroenterologists.

Dis Esophagus 2019 Jan 31. Epub 2019 Jan 31.

Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.

Published guidelines for the management of eosinophilic esophagitis (EoE) recommend an initial trial of proton pump inhibitors (PPI), histologic assessment for response to therapy, and tailoring treatments to patient needs and provider resources. Effectiveness studies directly comparing therapies are lacking, leaving a situation ripe for shared decision making. We aimed to assess gastroenterologists' adherence to guidelines and how they respond to EoE patients' preferences regarding management. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy133DOI Listing
January 2019
9 Reads

The impact of gastroesophageal reflux disease symptoms in scleroderma: effects on sleep quality.

Dis Esophagus 2019 Jan 31. Epub 2019 Jan 31.

Division of Gastroenterology and Hepatology.

Systemic scleroderma/sclerosis (SSc) is an autoimmune connective tissue disease, which can lead to esophageal motor dysfunction and gastroesophageal reflux disease (GERD). Nocturnal GERD symptoms may be associated with sleep disturbances, which in turn can drastically affect well-being and fatigue levels. We hypothesized that GERD symptoms would be associated with poorer sleep in patients with SSc. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy136DOI Listing
January 2019
8 Reads

A competing-risks nomogram and recursive partitioning analysis for cause-specific mortality in patients with esophageal neuroendocrine carcinoma.

Authors:
G Zhang B Wu X Wang J Li

Dis Esophagus 2019 Jan 31. Epub 2019 Jan 31.

Department of Thoracic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.

The objective of this study is to estimate the probability of cause-specific mortality using a competing-risks nomogram and recursive partitioning analysis in a large population-based cohort of patients with esophageal neuroendocrine carcinoma. The surveillance, epidemiology and end results database was used to identify 162 patients diagnosed with esophageal neuroendocrine carcinoma from 1998 to 2014. We estimated a cumulative incidence function for cause-specific mortality. Read More

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http://dx.doi.org/10.1093/dote/doy129DOI Listing
January 2019

Intensity-modulated radiotherapy at high-volume centers improves survival in patients with esophageal adenocarcinoma receiving trimodality therapy.

Dis Esophagus 2018 Dec 31. Epub 2018 Dec 31.

Department of Radiation Oncology, The warren Alpert Medical School of Brown university, Providence, USA.

The standard of care trimodality therapy for resectable locally advanced esophageal adenocarcinoma is complex and necessitates multidisciplinary care and expertise. In this work, it is hypothesized that facility clinical volume and utilization of intensity-modulated radiotherapy (IMRT) may influence outcomes. The National Cancer Data Base was queried for patients with cT1-4-N0-3 M0 esophageal adenocarcinoma undergoing trimodality therapy from 2004 to 2013 (n = 2445). Read More

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http://dx.doi.org/10.1093/dote/doy124DOI Listing
December 2018
1 Read

Validation of instruments for the assessment of dysphagia due to malignancy of the esophagus.

Dis Esophagus 2018 Dec 31. Epub 2018 Dec 31.

Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital.

The aim of the study was to validate the Watson scale, the Ogilvie scale, and the Goldschmid scale for assessment of dysphagia due to malignancy of the esophagus. After translation of the scales to Swedish, 35 patients with dysphagia due to esophageal malignancy were asked to participate. On day 1, patients were asked to fill in the questionnaires. Read More

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http://dx.doi.org/10.1093/dote/doy125DOI Listing
December 2018
1 Read

Preemptive endoluminal vacuum therapy to reduce anastomotic leakage after esophagectomy: a game-changing approach?

Dis Esophagus 2018 Dec 31. Epub 2018 Dec 31.

Department of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland.

Endoluminal vacuum therapy (EVT) is an accepted treatment for anastomotic leakage (AL) after esophagectomy. A novel concept is to use this technology in a preemptive setting, with the aim to reduce the AL rate and postoperative morbidity. Preemptive EVT (pEVT) was performed intraoperatively in 19 consecutive patients undergoing minimally invasive esophagectomy, immediately after completion of esophagogastrostomy. Read More

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http://dx.doi.org/10.1093/dote/doy126DOI Listing
December 2018
1 Read

The overall metastatic rate in early esophageal adenocarcinoma: long-time follow-up of surgically treated patients.

Dis Esophagus 2018 Dec 31. Epub 2018 Dec 31.

Department of Surgery I, Klinikum Darmstadt, Darmstadt, Germany.

The overall metastatic potential of surgically treated early esophageal adenocarcinoma has not been studied in detail. This paper therefore assessed lymph node metastases at surgery, loco regional and distant metastases, in order to assess the metastatic potential of early esophageal adenocarcinoma. Two hundred and seventeen patients (53 T1a, 164 T1b; median follow-ups 87 and 75 months, 187 males) diagnosed with early esophageal adenocarcinoma and treated with esophagectomy in our tertiary center's database between July 2000 and December 2015 were included. Read More

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http://dx.doi.org/10.1093/dote/doy127DOI Listing
December 2018
1 Read

Outcomes of octogenarians with esophageal cancer: an analysis of the National Cancer Database.

Dis Esophagus 2018 Dec 31. Epub 2018 Dec 31.

Department of Thoracic Medicine and Surgery, Temple University Hospital, Philadelphia, USA.

The optimal treatment of esophageal cancer in octogenarians is controversial. While the safety of esophagectomy has been demonstrated in elderly patients, surgery and multimodality therapy are still offered to a select group. Additionally, the long-term outcomes in octogenarians have not been thoroughly compared to those in younger patients. Read More

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http://dx.doi.org/10.1093/dote/doy128DOI Listing
December 2018
1 Read

Epidural analgesia after minimally invasive esophagectomy: efficacy and complication profile.

Dis Esophagus 2018 Dec 17. Epub 2018 Dec 17.

Department of Surgery, University Medical Center Utrecht, The Netherlands.

Adequate postoperative pain management is essential to facilitate uneventful recovery after esophagectomy. Although epidural analgesia is the gold standard, it is not satisfactory in all patients. The aim of this study is to describe the efficacy and complication profile of epidural analgesia after minimally invasive esophagectomy (MIE). Read More

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http://dx.doi.org/10.1093/dote/doy116DOI Listing
December 2018
1 Read

Reply to letter: Neoadjuvant chemoradiotherapy or chemotherapy for esophageal cancer: what is the current evidence?

Dis Esophagus 2019 Mar;32(3)

Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Theme Cancer, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1093/dote/doy101DOI Listing
March 2019
1 Read

Efficacy of triamcinolone-soaked polyglycolic acid sheet plus fully covered metal stent for preventing stricture formation after large esophageal endoscopic submucosal dissection.

Dis Esophagus 2019 Feb;32(2)

Department of Gastroenterology, Chinese PLA General Hospital, Beijing, China.

Esophageal stricture is a major problem for patients with large superficial esophageal squamous cell neoplasms (SESCNs) after endoscopic submucosal dissection (ESD). Although many measures could be used as prophylaxis for post-ESD strictures, a well-accepted method has not yet been established. We propose using a triamcinolone-soaked polyglycolic acid sheet plus fully covered metal stent (TS-PGA+FCMS) as a novel method to prevent stricture formation after large esophageal ESD. Read More

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http://dx.doi.org/10.1093/dote/doy121DOI Listing
February 2019
1 Read

Evolution of the surgical technique of minimally invasive Ivor-Lewis esophagectomy: description according to the IDEAL framework-but which IDEAL stage?

Authors:
A Hirst P McCulloch

Dis Esophagus 2018 Dec 17. Epub 2018 Dec 17.

IDEAL Collaboration, University of Oxford.

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http://dx.doi.org/10.1093/dote/doy122DOI Listing
December 2018
1 Read

Effervescent agents in acute esophageal food impaction.

Dis Esophagus 2019 Apr;32(4)

Division of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, Arizona, USA.

Acute esophageal food impaction (AEFI) occurs frequently. Few data are published describing the use of effervescent agents (EAs) for treatment of AEFI. We aimed to evaluate the effectiveness, cost, and safety of EAs in the treatment of AEFI. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy117DOI Listing
April 2019
11 Reads

Does DeMeester score still define GERD?

Dis Esophagus 2018 Dec 17. Epub 2018 Dec 17.

Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, USA.

Gastroesophageal reflux disease (GERD) clinical presentation may encompass a myriad of symptoms that may mimic other esophageal and extra-esophageal diseases. Thus, GERD diagnosis by symptoms only may be inaccurate. Upper digestive endoscopy and barium esophagram may also be misleading. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy118DOI Listing
December 2018
23 Reads

Intraoperative pyloric botulinum toxin injection during Ivor-Lewis gastroesophagectomy to prevent delayed gastric emptying.

Dis Esophagus 2018 Dec 17. Epub 2018 Dec 17.

Peninsula Oesophago-gastric Centre, University Hospitals Plymouth NHS Trust, united Kingdom.

Delayed gastric emptying (DGE) is a common morbidity that affects 10%-50% of Ivor-Lewis gastroesophagectomy (ILGO) patients. DGE management is variable with no gold standard prevention or treatment. We conducted a study to assess the effectiveness of intraoperative pyloric botulinum toxin injection in preventing DGE. Read More

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http://dx.doi.org/10.1093/dote/doy112DOI Listing
December 2018
3 Reads

Author's response regarding manuscript 'Evolution of the surgical technique of minimally invasive Ivor-Lewis esophagectomy: description according to the IDEAL framework'.

Dis Esophagus 2019 Feb;32(2)

Department of Surgery, Radboud University Medical Centre, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1093/dote/doy123DOI Listing
February 2019
1 Read

An anatomical hypothesis: a "concentric-structured model" for the theoretical understanding of the surgical anatomy in the upper mediastinum required for esophagectomy with radical mediastinal lymph node dissection.

Dis Esophagus 2018 Dec 17. Epub 2018 Dec 17.

Department of Esophageal Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Understanding the surgical anatomy is the key to reducing surgical invasiveness especially in the upper mediastinal dissection for esophageal cancer, which is supposed to have a significant impact on curability and morbidity. However, there is no theoretical recognition regarding the surgical anatomy required for esophagectomy, although the surgical anatomy in abdominal digestive surgery has been developed on the basis of embryological findings of intestinal rotation and fusion fascia. Therefore, we developed a hypothesis of a 'concentric-structured model' of the surgical anatomy in the upper mediastinum based on human embryonic development. Read More

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http://dx.doi.org/10.1093/dote/doy119DOI Listing
December 2018
1 Read

Normal radiological lymph node appearance in the thorax.

Dis Esophagus 2018 Dec 17. Epub 2018 Dec 17.

Department of Surgical Sciences.

Modern treatment of esophageal cancer is multimodal and highly dependent on a detailed diagnostic assessment of clinical stage, which includes nodal stage. Clinical appraisal of nodal stage is highly dependent on knowledge of normal radiological appearance, information of which is scarce. We aimed to describe lymph node appearance on computed tomography (CT) investigations in a randomly selected cohort of healthy subjects. Read More

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http://dx.doi.org/10.1093/dote/doy120DOI Listing
December 2018
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Wide-area transepithelial sampling with computer-assisted 3-dimensional analysis (WATS) markedly improves detection of esophageal dysplasia and Barrett's esophagus: analysis from a prospective multicenter community-based study.

Dis Esophagus 2019 Mar;32(3)

Gastroenterology, New York University Langone Medical Center, New York, NY, USA.

The 4-quadrant forceps biopsy (FB) protocol for identifying Barrett's esophagus (BE) and esophageal dysplasia (ED) suffers from poor sensitivity due to significant sampling error. We investigated the benefit of wide-area transepithelial sampling with 3-dimensional computer-assisted analysis (WATS) used adjunctively to the combination of random and targeted FB in the detection of ED, and as a secondary outcome, BE. In this multicenter prospective trial, community endoscopists at 21 sites utilized WATS as an adjunct to both targeted and random FB in patients undergoing BE screening and surveillance. Read More

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http://dx.doi.org/10.1093/dote/doy099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403460PMC
March 2019
5 Reads

Association of preoperative inflammation-based prognostic score with survival in patients undergoing salvage esophagectomy.

Dis Esophagus 2019 Apr;32(4)

Department of Gastrointestinal Surgery, Graduate School of Medicine, the University of Tokyo.

Salvage esophagectomy (SALV) is potentially beneficial for patients with residual or relapsed esophageal carcinoma after definitive chemoradiotherapy (dCRT), although preoperatively identifying good candidates for SALV remains difficult. We investigated the prognostic impacts of inflammatory and nutritional status in patients undergoing SALV after dCRT. Forty-seven SALV patients were retrospectively reviewed, of whom 46 (98%) had squamous cell carcinoma and 1 (2%) adenocarcinoma. Read More

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http://dx.doi.org/10.1093/dote/doy066DOI Listing
April 2019
1 Read

Preoperative endoscopic pyloric balloon dilatation decreases the rate of delayed gastric emptying after Ivor-Lewis esophagectomy.

Dis Esophagus 2018 Dec 1. Epub 2018 Dec 1.

Department of General-, Visceral-, and Transplant Surgery, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Delayed gastric emptying (DGE) after Ivor-Lewis esophagectomy occurs postoperatively in up to 50% of the patients. This pyloric dysfunction can lead to severe secondary complications postoperatively such as early aspiration, pneumonia or may even have an impact on anastomotic healing and therefore leakage. Early detection of DGE is essential to prevent further complications. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy097DOI Listing
December 2018
18 Reads

Associated risks of proton pump inhibitors and their influence on prescribing habits: is change truly warranted?

Authors:
A Dua M Venu

Dis Esophagus 2019 Apr;32(4)

Loyola University Medical Center, Division of Gastroenterology , Stritch School of Medicine, Maywood, Illinois, USA.

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy103DOI Listing
April 2019
2 Reads

A biomarker panel predicts progression of Barrett's esophagus to esophageal adenocarcinoma.

Dis Esophagus 2019 Jan;32(1)

Medical Research Council Cancer Unit, Hutchison-MRC Research Center, University of Cambridge,Cambridge,United Kingdom.

Progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC) is uncommon but the consequences are serious. Predictors of progression are essential to optimize resource utilization. This study assessed the utility of a promising panel of biomarkers applicable to routine paraffin embedded biopsies (FFPE) to predict progression of BE to EAC in a large population-based, nested case-control study. Read More

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http://dx.doi.org/10.1093/dote/doy102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303732PMC
January 2019
7 Reads