6,263,046 results match your criteria Diseases of the Esophagus [Journal]

  • Page 1 of 125261

Evaluation of in vitro antimicrobial susceptibility of strains isolated during anthrax outbreaks in Italy from 1984 to 2017.

J Vet Sci 2018 Dec 4. Epub 2018 Dec 4.

Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata, Anthrax Reference Institute of Italy, Foggia 71121, Italy.

Anthrax, caused by , is a non-contagious infectious disease that affects a wide range of animal species (primarily ruminants), as well as humans. Due to the often fatal outcome in human cases, the quick administration of definitely effective antimicrobials is crucial either as prophylaxis or for the therapy of clinical cases. In this study, a total of 110 strains, temporally, geographically and genetically different, isolated during anthrax outbreaks in Italy from 1984 to 2017, were screened for their susceptibility towards 16 clinically relevant antimicrobial agents using the broth microdilution method. Read More

View Article
December 2018

Genome-wide association study of degenerative mitral valve disease in Maltese dogs.

J Vet Sci 2018 Dec 4. Epub 2018 Dec 4.

Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, 05030, Korea.

Genome-wide association study (GWAS) is a powerful tool for identifying the genetic causes of various diseases. This study conducted to identify genomic variation in Maltese dog genomes associated with degenerative mitral valve disease (DMVD) development and evaluate the association of each biological condition with DMVD in Maltese dogs. DNA was extracted from blood samples obtained from 48 Maltese dogs (32 with DMVD and 16 controls). Read More

View Article
December 2018
1 Read

Association between Dietary Glycemic Index and Excess Weight in Pregnant Women in the First Trimester of Pregnancy.

Rev Bras Ginecol Obstet 2018 Dec 12. Epub 2018 Dec 12.

Group of Research in Nutrition and Chronic Diseases, Universidade Estadual do Ceará, Fortaleza, CE, Brazil.

Objective:  To assess the association between dietary glycemic index (GI) and excess weight in pregnant women in the first trimester of pregnancy.

Methods:  A cross-sectional study in a sample of 217 pregnant women was conducted at the maternal-fetal outpatient clinic of the Hospital Geral de Fortaleza, Fortaleza, state of Ceará, Brazil, for routine ultrasound examinations in the period between 11 and 13 weeks + 6 days of gestation. Weight and height were measured and the gestational body mass index (BMI) was calculated. Read More

View Article
December 2018
3 Reads

Imaging Description of Extragenital Müllerian Adenosarcoma: A Case Report.

Rev Bras Ginecol Obstet 2018 Dec 12. Epub 2018 Dec 12.

Section of Obstetrics and Gynecology, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.

Müllerian adenosarcoma is a very rare gynecological disease, comprising 5% of uterine sarcomas. Extragenital localizations are even rarer. We report a very interesting case of a 27-year-old woman complaining of pelvic pain, with a subsequent diagnosis of extragenital Müllerian adenosarcoma. Read More

View Article
December 2018
1 Read

[Update of multimodal therapy in canine osteoarthritis].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):337-345. Epub 2018 Dec 12.

Canine osteoarthritis is a very common disease and the main cause for chronic pain in dogs. Progressive degeneration of joint cartilage, periarticular soft tissues and subchondral bone consecutively lead to osteophytes, inflammation and pain. It is an irreversible process. Read More

View Article
October 2018

Update on therapy and prevention of canine leishmaniasis.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):315-322. Epub 2018 Dec 12.

Canine leishmaniasis is an emerging infection with increasing importance because the main vector also exists in Germany and autochthonous infections have been described. In this article we present the latest information available regarding therapy and prevention of this disease. Allopurinol-resistant strains were isolated from dogs which experienced recurrent disease while being treated with allopurinol, highlighting the need for alternative treatment options. Read More

View Article
October 2018
1 Read

[Cobalamin deficiency in dogs and cats].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):309-314. Epub 2018 Dec 12.

Cobalamin is a member of the B-group of vitamins and a cofactor for metabolic processes like nucleic acid synthesis, amino acid synthesis, and the citric acid cycle. Mammals are unable to synthesize cobalamin and therefore rely on adequate food intake. Cobalamin absorption is a complex process in the stomach, duodenum, and ileum, requiring a functional exocrine pancreas. Read More

View Article
October 2018
1 Read

Investigations on the prevalence of tortoise picorna-virus in captive tortoises in Germany.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):304-308. Epub 2018 Dec 12.

Objective: Tortoise picornavirus (ToPV) has been speculated to play an important role in the frequently seen disease pattern of juvenile shell softening. This study aimed to determine ToPV prevalence among German tortoise collections.

Material And Methods: A total of 334 animals selected from 27 different collections were included. Read More

View Article
October 2018

[Diagnostic value of the BRAF variant V595E in urine samples, smears and biopsies from canine transitional cell carcinoma].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):289-295. Epub 2018 Dec 12.

Objective: Transitional cell carcinoma (TCC) is the most common malignant tumour of the canine urinary tract. Previously, the mutation of the BRAF gene V595E was identified in approximately 85 % of canine TCC cases by DNA sequencing of TCC tumour cells, both in frozen and paraffin-embedded tissue sections, as well as in urine. The objective of this study was to establish these methods in cytological smears and to investigate the prevalence of BRAF mutation V595E in canine TCC in our cohort of patients. Read More

View Article
October 2018
1 Read

A Female Patient with Xq28 Microduplication Presenting with Myotubular Myopathy, Confirmed with a Custom-Designed X-array.

Neuropediatrics 2018 Dec 12. Epub 2018 Dec 12.

Department of Medical Genetics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

X-linked myotubular myopathy (XLMTM) is a rare inherited neuromuscular disorder associated with mutations in the gene on the Xq28 region. We report a severely affected girl with XLMTM, caused by maternally inherited 661 kb Xq28 microduplication identified by chromosomal microarray analysis and confirmed also on DNA from muscle biopsy with a custom-designed X-chromosome-specific microarray. X-inactivation analysis revealed a skewed inactivation pattern on the proband's muscle biopsy. Read More

View Article
December 2018

A multimodal (FACILE) classification for optical diagnosis of inflammatory bowel disease associated neoplasia.

Endoscopy 2018 Dec 12. Epub 2018 Dec 12.

Division of Gastroenterology, HSK Hospital, Wiesbaden, Germany.

Background:  Characterization of colonic lesions in inflammatory bowel disease (IBD) remains challenging. We developed an endoscopic classification of visual characteristics to identify colitis-associated neoplasia using multimodal advanced endoscopic imaging (Frankfurt Advanced Chromoendoscopic IBD LEsions [FACILE] classification).

Methods:  The study was conducted in three phases: 1) development - an expert panel defined endoscopic signs and predictors of dysplasia in IBD and, using multivariable logistic regression created the FACILE classification; 2) validation - using 60 IBD lesions from an image library, two assessments of diagnostic accuracy for neoplasia were performed and interobserver agreement between experts using FACILE was determined; 3) reproducibility - the reproducibility of the FACILE classification was tested in gastroenterologists, trainees, and junior doctors after completion of a training module. Read More

View Article
December 2018

Burden of disease (BoD), disability-adjusted life years (DALY) and frailty prevalence.

QJM 2018 Dec 12. Epub 2018 Dec 12.

Clinical Sciences Institute, National University of Ireland, Galway (NUIG), Galway City, Ireland.

Background: Burden of disease (BoD) using disability-adjusted life years (DALY) is a useful summary measure of population health and estimates are provided for Ireland annually. We hypothesised that BoD may be used as a predictor of frailty prevalence.

Aim: To examine the correlation between frailty measured by the accumulation of deficits (frailty index, FI) and Fried Frailty Phenotype (FFP) classifications and BoD, in an Irish context. Read More

View Article
December 2018
1 Read

Xenotransplantation: Progress Along Paths Uncertain from Models to Application.

ILAR J 2018 Dec 12. Epub 2018 Dec 12.

Translational Medicine and The Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina.

For more than a century, transplantation of tissues and organs from animals into man, xenotransplantation, has been viewed as a potential way to treat disease. Ironically, interest in xenotransplantation was fueled especially by successful application of allotransplantation, that is, transplantation of human tissue and organs, as a treatment for a variety of diseases, especially organ failure because scarcity of human tissues limited allotransplantation to a fraction of those who could benefit. In principle, use of animals such as pigs as a source of transplants would allow transplantation to exert a vastly greater impact than allotransplantation on medicine and public health. Read More

View Article
December 2018
2 Reads

Applied Institutional Approaches for the Evaluation and Management of Zoonoses in Contemporary Laboratory Animal Research Facilities.

ILAR J 2018 Dec 12. Epub 2018 Dec 12.

Department of Population Health, University of Georgia College of Veterinary Medicine, Athens, Georgia.

Zoonoses, diseases transmitted between animals and humans, have been a concern in laboratory animal medicine for decades. Exposure to zoonotic organisms not only poses health risks to personnel and research animals but may also affect research integrity. Early laboratory animal programs were ineffective at excluding and preventing transmission of zoonotic diseases: the health status of the animals were often unknown, endemic diseases occurred frequently, housing conditions were less controlled, and veterinary care programs were decentralized. Read More

View Article
December 2018

Assessment of Bowel Inflammation and Strictures by Magnetic Resonance Enterography in Long-term Crohn´s Disease.

J Crohns Colitis 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology, Akershus University Hospital, Lørenskog, Norway.

Background: Crohns disease (CD) is a chronic inflammation in the gut that often progresses to fibrosis. Magnetic Resonance Enterography (MRE) is an important diagnostic tool in evaluating CD. We aimed to assess the prevalence of inflammation and stricturing disease in patients with long-term CD and investigate associations with clinical factors. Read More

View Article
December 2018

Pancreatic Islet Transplantation in Humans: Recent Progress and Future Directions.

Endocr Rev 2018 Dec 12. Epub 2018 Dec 12.

Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA.

Pancreatic islet transplantation has become an established approach to β-cell replacement therapy for the treatment of insulin deficient diabetes. Recent progress in techniques for islet isolation, islet culture, and peri-transplant management of the islet transplant recipient have resulted in substantial improvements in metabolic and safety outcomes for patients. For patients requiring total or sub-total pancreatectomy for benign disease of the pancreas, isolation of islets from the diseased pancreas with intrahepatic transplantation of autologous islets can prevent or ameliorate post-surgical diabetes, and for patients previously experiencing painful recurrent acute or chronic pancreatitis, quality-of-life is substantially improved. Read More

View Article
December 2018
1 Read

Household transmission of seasonal influenza from HIV-infected and -uninfected individuals in South Africa, 2013-2014.

J Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.

Background: Differential transmission from HIV-infected compared to HIV-uninfected individuals may impact influenza burden. We estimated the household secondary infection risk (SIR) and serial interval (SI) for influenza transmission from HIV-infected and HIV-uninfected index cases and identified associated factors.

Methods: Index cases were the first symptomatic person in a household with influenza-like illness, testing influenza positive on real-time reverse transcription polymerase chain reaction (rRT-PCR). Read More

View Article
December 2018

MAGE genes in the kidney: identification of MAGED2 as upregulated during kidney injury and in stressed tubular cells.

Nephrol Dial Transplant 2018 Dec 11. Epub 2018 Dec 11.

Nephrology, IIS-Fundacion Jimenez Diaz-Universidad Autonoma de Madrid and Fundacion Renal Iñigo Alvarez de Toledo-IRSIN, Madrid, Spain.

Background: Mutations in Melanoma Antigen-encoding Gene D2 (MAGED2) promote tubular dysfunction, suggesting that MAGE proteins may play a role in kidney pathophysiology. We have characterized the expression and regulation of MAGE genes in normal kidneys and during kidney disease.

Methods: The expression of MAGE genes and their encoded proteins was explored by systems biology multi-omics (kidney transcriptomics and proteomics) in healthy adult murine kidneys and following induction of experimental acute kidney injury (AKI) by a folic acid overdose. Read More

View Article
December 2018

The relationship between type 1 IFN and vasculopathy in anti-MDA5 antibody-positive dermatomyositis patients.

Rheumatology (Oxford) 2018 Dec 11. Epub 2018 Dec 11.

Department of Rheumatology, Faculty of Medicine, Saga University, Saga, Japan.

Objectives: Based on the antibody profiles of inflammatory myositis patients, we investigated the type 1 IFN (T1-IFN) signature in serum and DM skin to determine the relationship between T1-IFN and vasculopathy in anti-melanoma differentiation-associated 5 gene (MDA5) antibody-positive DM patients.

Methods: We examined 47 patients with new-onset inflammatory myositis. We divided them into three groups: the anti-MDA5 antibody-positive patients (MDA5 group, n = 16), the anti-aminoacyl-tRNA synthetase antibody-positive patients (aminoacyl-tRNA synthetase group, n = 12), and the double-negative patients (n = 19). Read More

View Article
December 2018
1 Read

Capsular polysaccharide in Mycoplasma mycoides is a virulence factor.

J Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

J. Craig Venter Institute, Rockville, MD USA.

Capsular polysaccharides have been confirmed to be an important virulence trait in many different Gram-positive and Gram-negative bacteria. Similarly, they are proposed to be virulence traits in minimal Mycoplasma that cause disease in humans and animals. In this study, goats were infected with the caprine pathogen Mycoplasma mycoides subsp. Read More

View Article
December 2018

A coronary artery disease-associated tRNAThr mutation altered mitochondrial function, apoptosis and angiogenesis.

Nucleic Acids Res 2018 Dec 12. Epub 2018 Dec 12.

Division of Medical Genetics and Genomics, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, China.

The tissue specificity of mitochondrial tRNA mutations remains largely elusive. In this study, we demonstrated the deleterious effects of tRNAThr 15927G>A mutation that contributed to pathogenesis of coronary artery disease. The m. Read More

View Article
December 2018

The Gly385(388)Arg Polymorphism of the FGFR4 Receptor regulates Hepatic Lipogenesis under healthy Diet.

J Clin Endocrinol Metab 2018 Dec 12. Epub 2018 Dec 12.

Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tübingen, Germany.

Context: The effect of a lifestyle intervention to reduce liver fat content in nonalcoholic fatty liver disease in humans is influenced by genetics. We hypothesized that the functionally active amino acid exchange in humans Gly388Arg (mouse homologue: Gly385Arg) in the fibroblast growth factor receptor 4 (FGFR4), which regulates bile acid, lipid and glucose metabolism, may determine the dynamics of hepatic lipid accumulation and insulin sensitivity in humans. Mechanisms of this substitution were studied in mice under normal chow and high-fat diet. Read More

View Article
December 2018
1 Read

Detecting moderate or complex congenital heart defects in adults from an electronic health records system.

J Am Med Inform Assoc 2018 Dec;25(12):1634-1642

Emory University School of Medicine, Atlanta, GA, USA.

Background: The prevalence of moderate or complex (moderate-complex) congenital heart defects (CHDs) among adults is increasing due to improved survival, but many patients experience lapses in specialty care or their CHDs are undocumented in the medical system. There is, to date, no efficient approach to identify this population.

Objective: To develop and assess the performance of a risk score to identify adults aged 20-60 years with undocumented specific moderate-complex CHDs from electronic health records (EHR). Read More

View Article
December 2018
3 Reads

Classification of chronic kidney disease 10 years on: what have we learnt in the Netherlands.

Fam Pract 2018 Dec;35(6):744-745

Department of Primary and Community Care, Radboud university medical center, Nijmegen, the Netherlands.

View Article
December 2018

Improvement in insulin sensitivity and serum leptin concentration after the switch from a ritonavir-boosted PI to raltegravir or dolutegravir in non-diabetic HIV-infected patients.

J Antimicrob Chemother 2018 Dec 12. Epub 2018 Dec 12.

Department of Medical and Surgical Sciences, Unit of Infectious Diseases, 'Alma Mater Studiorum' University of Bologna, S. Orsola-Malpighi Hospital, via Massarenti 11, Bologna, Italy.

Objectives: An observational, prospective, cohort study was performed to assess changes in insulin sensitivity and serum leptin level after a switch from a ritonavir-boosted PI (PI/r) to raltegravir or dolutegravir in HIV-infected adults on stable combination ART (cART).

Methods: Non-diabetic HIV-infected patients receiving suppressive cART including tenofovir disoproxil fumarate/emtricitabine plus one PI/r, who underwent a switch from the PI/r to raltegravir (group A) or dolutegravir (group B), were enrolled in the study. Serum levels of insulin, leptin and the homeostasis model assessment of insulin resistance (HOMA) index were evaluated during a 12 month follow-up. Read More

View Article
December 2018

University athletes and changes in cardiac geometry: insight from the 2015 Gwangju Summer Universiade.

Eur Heart J Cardiovasc Imaging 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiovascular Medicine, Chonnam National University Hospital, 42 Jebong-ro, Dong-gu, Gwangju, Korea.

Aims: There is a paucity of data regarding the changes of cardiac geometry in highly trained international and multiracial university athletes. We aimed to investigate the incidence of structural cardiac abnormalities and changes of cardiac geometry in highly trained university athletes.

Methods And Results: Comprehensive echocardiographic studies were performed in 1185 university athletes through the Check-up Your Heart Program during the 2015 Gwangju Summer Universiade. Read More

View Article
December 2018

Effect of Sleep Quality on aMCI Vulnerable Brain Regions in Cognitively Normal Elderly Individuals.

Sleep 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychiatry and Behavioral Sciences.

Study Objectives: This study aims to evaluate the extent to which sleep quality impacts amnestic mild cognitive impairment (aMCI)-related brain regions in a cognitively normal cohort of individuals.

Methods: Seventy four participants were rigorously evaluated using a battery of cognitive tests and a detailed clinical assessment to verify normal cognitive status. We then screened for sleep quality using the Pittsburgh Sleep Quality Index (PSQI) and depressive symptoms using the Geriatric Depression Scale (GDS). Read More

View Article
December 2018

Educational level and risk of chronic kidney disease: longitudinal data from the PREVEND study.

Nephrol Dial Transplant 2018 Dec 12. Epub 2018 Dec 12.

Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: The longitudinal association between low education and chronic kidney disease (CKD) and its underlying mechanisms is poorly characterized. We therefore examined the association of low education with incident CKD and change in kidney function, and explored potential mediators of this association.

Methods: We analysed data on 6078 participants from the community-based Prevention of Renal and Vascular End-stage Disease study. Read More

View Article
December 2018

Hypertension in chronic kidney disease: Nephrology Dialysis Transplantation notable 2017 advances.

Nephrol Dial Transplant 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, Indiana University School of Medicine and Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA.

View Article
December 2018

The role of glutamine metabolism for host defense against Mycobacterium tuberculosis infection.

J Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Radboud university medical center, Department of Internal Medicine and Radboud Center of Infectious Diseases, Nijmegen, the Netherlands.

Background: Rewiring cellular metabolism is important for activation of immune cells during host defense against Mycobacterium tuberculosis. Glutamine has been implicated as an immunomodulatory nutrient, but its role in response to M. tuberculosis is unknown. Read More

View Article
December 2018
1 Read

Validated screening tools for the assessment of cachexia, sarcopenia, and malnutrition: a systematic review.

Am J Clin Nutr 2018 Dec;108(6):1196-1208

Clinical Surgery, University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom.

Background: There is great overlap between the presentation of cachexia, sarcopenia, and malnutrition. Distinguishing between these conditions would allow for better targeted treatment for patients.

Objectives: The aim was to systematically review validated screening tools for cachexia, sarcopenia, and malnutrition in adults and, if a combined tool is absent, make suggestions for the generation of a novel screening tool. Read More

View Article
December 2018
1 Read

A 12-wk whole-grain wheat intervention protects against hepatic fat: the Graandioos study, a randomized trial in overweight subjects.

Am J Clin Nutr 2018 Dec;108(6):1264-1274

Wageningen University, Division of Human Nutrition, Wageningen, The Netherlands.

Background: Whole-grain wheat (WGW) is described as nutritionally superior to refined wheat (RW) and thus advocated as the healthy choice, although evidence from intervention studies is often inconsistent. The liver, as the central organ in energy metabolism, might be an important target organ for WGW interventions.

Objective: The aim of this study was to investigate the potential benefits of WGW consumption compared with RW consumption on liver health and associated parameters. Read More

View Article
December 2018

Severe vitamin D deficiency is a risk factor for renal hyperfiltration.

Am J Clin Nutr 2018 Dec;108(6):1342-1351

Department of Internal Medicine, College of Medicine, Institute of Kidney Disease Research.

Background: Vitamin D deficiency is associated with renal progression in chronic kidney disease. Moreover, improvement of clinical outcomes after vitamin D supplementation has been reported in the diabetic and chronic kidney disease population.

Objective: We investigated the association between renal hyperfiltration (RHF) and vitamin D status in a relatively healthy population. Read More

View Article
December 2018

In Vivo Imaging With Confirmation by Histopathology for Increased Rigor and Reproducibility in Translational Research: A Review of Examples, Options, and Resources.

ILAR J 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology, Miller Research Building Molecular Imaging Service Center, Johns Hopkins University, Baltimore, Maryland.

Preclinical noninvasive imaging can be an indispensable tool for studying animal models of disease. In vivo imaging to assess anatomical, functional, and molecular features requires verification by a comparison to the macroscopic and microscopic morphological features, since all noninvasive in vivo imaging methods have much lower resolution than standard histopathology. Comprehensive pathological evaluation of the animal model is underutilized; yet, many institutions have veterinary or human pathologists with necessary comparative pathology expertise. Read More

View Article
December 2018

Factors that can influence the survival rates of coral snakes (Micrurus corallinus) for antivenom production.

J Anim Sci 2018 Dec 12. Epub 2018 Dec 12.

Laboratório de Herpetologia do Instituto Butantan, Av. Vital Brazil, São Paulo - Brasil.

Envenoming and deaths resulting from snakebites are a particularly important public health problem in rural tropical areas of Africa, Asia, Latin America and New Guinea. In 2015 The Lancet highlighted snake-bite envenoming as a neglected tropical disease and urged the world to increase antivenom production. In Brazil around 20,000 snakebites occur per year affecting mostly agricultural workers and children, of which 1% are caused by coral snakes (Micrurus sp). Read More

View Article
December 2018

Older HIV+ and HIV- Adults Provide Similar Definitions of Successful Aging: A Mixed-Methods Examination.

Gerontologist 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychiatry, University of California, San Diego.

Background And Objective: As HIV-infected (HIV+) individuals age, there is a need to understand successful aging (SA) from the patient perspective. This study compared SA definitions between HIV+ and HIV-uninfected (HIV-) older adults and then examined correlates of SA categories.

Research Design And Methods: Ninety-three HIV+ and 46 HIV- older (aged 50+) adults provided brief definitions of SA, which was examined using content analysis. Read More

View Article
December 2018
1 Read

Prognostic value of left atrial strain in predicting cardiovascular morbidity and mortality in the general population.

Eur Heart J Cardiovasc Imaging 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiology, Herlev & Gentofte Hospital, University of Copenhagen, Denmark.

Aims: Left atrial (LA) enlargement predicts cardiovascular risk. The prognostic value of left atrial peak reservoir strain (LA RS) by two-dimensional speckle tracking in the general population is currently unknown. This study sought to determine the prognostic value of LA RS in the general population. Read More

View Article
December 2018

Implementation of a Stirling number estimator enables direct calculation of population genetics tests for large sequence data sets.

Authors:
Swaine L Chen

Bioinformatics 2018 Dec 12. Epub 2018 Dec 12.

Department of Medicine, Division of Infectious Diseases, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; and Infectious Diseases Group, Genome Institute of Singapore, Singapore.

Motivation: Stirling numbers enter into the calculation of several population genetics statistics, including Fu's Fs. However, as alignments become large (>∼50 sequences), the Stirling numbers required rapidly exceed the standard floating point range. Another recursive method for calculating Fu's Fs suffers from floating point underflow issues. Read More

View Article
December 2018

Effect of Salvia Miltiorrhiza Injection in Patients With Autologous Fat Grafting to the Breast: A Preliminary Comparative Study.

Aesthet Surg J 2018 Dec 12. Epub 2018 Dec 12.

Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

Background: Salvia miltiorrhiza (SM) is a herb used in Chinese medicine formulations for promoting blood circulation and minimizing vascular stasis. It has been successfully utilized in treating cardiovascular diseases, such as atherosclerosis, thromboembolism, and angina.

Objective: To study the effect of SM injections in autologous fat grafting to the breast. Read More

View Article
December 2018

Cancer stem cells in relation to treatment.

Jpn J Clin Oncol 2018 Dec 12. Epub 2018 Dec 12.

Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

The classical cancer therapies, including chemotherapy and radiation therapy, can initially show good results and tumor shrinkage; however, for most cancer patients disease recurrence is a common event. This tumor regrowth following therapy is now thought to depend on a small population of cancer stem cells (CSCs), which, similar to other stem cells, have the capacity for self-renewal and multipotent differentiation. Cancer stem cells have been identified based on cell surface protein expression in many tumor types, and for all diseases studied, this specific cell population is required for serial transplantation in animal models. Read More

View Article
December 2018

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer.

Authors:
Naomi Walsh Han Zhang Paula L Hyland Qi Yang Evelina Mocci Mingfeng Zhang Erica J Childs Irene Collins Zhaoming Wang Alan A Arslan Laura Beane-Freeman Paige M Bracci Paul Brennan Federico Canzian Eric J Duell Steven Gallinger Graham G Giles Michael Goggins Gary E Goodman Phyllis J Goodman Rayjean J Hung Charles Kooperberg Robert C Kurtz Núria Malats Loic LeMarchand Rachel E Neale Sara H Olson Ghislaine Scelo Xiao O Shu Stephen K Van Den Eeden Kala Visvanathan Emily White Wei Zheng Demetrius Albanes Gabriella Andreotti Ana Babic William R Bamlet Sonja I Berndt Ayelet Borgida Marie-Christine Boutron-Ruault Lauren Brais Paul Brennan Bas Bueno-de-Mesquita Julie Buring Kari G Chaffee Stephen Chanock Sean Cleary Michelle Cotterchio Lenka Foretova Charles Fuchs J Michael M Gaziano Edward Giovannucci Michael Goggins Thilo Hackert Christopher Haiman Patricia Hartge Manal Hasan Kathy J Helzlsouer Joseph Herman Ivana Holcatova Elizabeth A Holly Robert Hoover Rayjean J Hung Vladimir Janout Eric A Klein Robert C Kurtz Daniel Laheru I-Min Lee Lingeng Lu Núria Malats Satu Mannisto Roger L Milne Ann L Oberg Irene Orlow Alpa V Patel Ulrike Peters Miquel Porta Francisco X Real Nathaniel Rothman Howard D Sesso Gianluca Severi Debra Silverman Oliver Strobel Malin Sund Mark D Thornquist Geoffrey S Tobias Jean Wactawski-Wende Nick Wareham Elisabete Weiderpass Nicolas Wentzensen William Wheeler Herbert Yu Anne Zeleniuch-Jacquotte Peter Kraft Donghui Li Eric J Jacobs Gloria M Petersen Brian M Wolpin Harvey A Risch Laufey T Amundadottir Kai Yu Alison P Klein Rachael Z Stolzenberg-Solomon

J Natl Cancer Inst 2018 Dec 12. Epub 2018 Dec 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Background: Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a powerful tool to identify networks of susceptibility genes.

Methods: We conducted a large agnostic pathway-based meta-analysis of GWAS data using the summary-based adaptive rank truncated product method to identify gene sets and pathways associated with pancreatic ductal adenocarcinoma (PDAC) in 9040 cases and 12 496 controls. Read More

View Article
December 2018

Examining associations between physical activity and cardiovascular mortality using negative control outcomes.

Int J Epidemiol 2018 Dec 11. Epub 2018 Dec 11.

Charles Perkins Centre, University of Sydney, Sydney, Australia.

Background: The purpose of a negative control is to reproduce a condition that cannot involve the hypothesized causal mechanism, but does involve the same sources of bias and confounding that may distort the primary association of interest. Observational studies suggest physical inactivity is a major risk factor for cardiovascular disease (CVD), although potential sources of bias, including reverse causation and residual confounding, make it difficult to infer causality. The aim was to employ a negative control outcome to explore the extent to which the association between physical activity and CVD mortality is explained by confounding. Read More

View Article
December 2018

Single-dose radical cure for Plasmodium vivax.

Authors:
Kevin C Kain

J Travel Med 2018 Dec 12. Epub 2018 Dec 12.

Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto; SAR Laboratories, Sandra Rotman Centre for Global Health, University Health Network-Toronto General Hospital, University of Toronto, Toronto, Canada.

View Article
December 2018

DNA damage and repair in the female germline: contributions to ART.

Hum Reprod Update 2018 Dec 12. Epub 2018 Dec 12.

Priority Research Centre for Reproductive Science, Discipline of Biological Sciences, University of Newcastle, Callaghan, NSW, Australia.

Background: DNA integrity and stability are critical determinants of cell viability. This is especially true in the female germline, wherein DNA integrity underpins successful conception, embryonic development, pregnancy and the production of healthy offspring. However, DNA is not inert; rather, it is subject to assault from various environment factors resulting in chemical modification and/or strand breakage. Read More

View Article
December 2018
1 Read

A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease.

Hum Mol Genet 2018 Dec 12. Epub 2018 Dec 12.

KU Leuven - Department of Neurosciences, Laboratory for Neuroimmunology, B-3000 Leuven, Belgium.

The role of somatic variants in diseases beyond cancer is increasingly being recognized, with potential roles in autoinflammatory and autoimmune diseases. However, as mutation rates and allele fractions are lower, studies in these diseases are substantially less tolerant of false positives and bio-informatics algorithms require high replication rates. We developed a pipeline combining two variant callers, MuTect2 and VarScan2, with technical filtering and prioritization. Read More

View Article
December 2018

Safety Considerations When Working with Humanized Animals.

ILAR J 2018 Dec 12. Epub 2018 Dec 12.

Unit for Laboratory Animal Medicine, University of Michigan Medical School in Ann Arbor, Michigan.

Research using laboratory animals has been revolutionized by the creation of humanized animal models, which are immunodeficient animals engrafted with human cells, tissues, or organs. These animal models provide the research community a unique and promising opportunity to mimic a wide variety of disease conditions in humans, from infectious disease to cancer. A vast majority of these models are humanized mice like those injected with human CD34+ hematopoietic stem cells and patient-derived xenografts. Read More

View Article
December 2018

The Na+/H+ Exchanger Nhe1 Modulates Network Excitability via GABA Release.

Cereb Cortex 2018 Dec 12. Epub 2018 Dec 12.

Institute of Human Genetics, Jena University Hospital, Jena, Germany.

Brain functions are extremely sensitive to pH changes because of the pH-dependence of proteins involved in neuronal excitability and synaptic transmission. Here, we show that the Na+/H+ exchanger Nhe1, which uses the Na+ gradient to extrude H+, is expressed at both inhibitory and excitatory presynapses. We disrupted Nhe1 specifically in mice either in Emx1-positive glutamatergic neurons or in parvalbumin-positive cells, mainly GABAergic interneurons. Read More

View Article
December 2018
1 Read

Detection of IgG1 against rK39 improves monitoring of treatment outcome in visceral leishmaniasis.

Clin Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Faculty of Medicine, University of Khartoum, Sudan.

Background: Visceral leishmaniasis (VL), caused by the Leishmania donovani complex, is a fatal neglected tropical disease that is targeted for elimination in India, Nepal and Bangladesh. Improved diagnostic tests are required for early case detection and for monitoring outcome of treatment. Previous investigations using Leishmania lysate antigen demonstrated that IgG1 response is a potential indicator of clinical status after chemotherapy. Read More

View Article
December 2018

Management of paediatric patients with medically-refractory Crohn's disease using Ustekinumab: A multi-centred cohort study.

J Crohns Colitis 2018 Dec 12. Epub 2018 Dec 12.

Division of Gastroenterology, Montreal Children's Hospital, Department of Paediatrics, McGill University, Montreal, Quebec, Canada.

Background: Ustekinumab (UST) is effective in the treatment of adults with moderate to severe Crohn's disease (CD). There is a paucity of data on its use in children.

Aim: To evaluate the response to UST in children with moderate to severe CD. Read More

View Article
December 2018
1 Read
  • Page 1 of 125261