2,323 results match your criteria Diseases of the Esophagus [Journal]


Comparison of mediastinal lymph node metastases from adenocarcinoma of the esophagogastric junction versus lower esophageal squamous cell carcinoma with involvement of the esophagogastric junction.

Dis Esophagus 2019 Feb 22. Epub 2019 Feb 22.

Clinical Trial Planning and Management, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Ariake, Koto-ku, Tokyo, Japan.

The distribution of mediastinal lymph node metastasis in patients with adenocarcinoma of the esophagogastric junction (AEG) remains unclear. Additionally, the distribution of nodal mediastinal metastasis from squamous cell carcinoma (SCC) of the lower esophagus with involvement of the esophagogastric junction remains unclear, given the very limited number of these patients. In this retrospective review, we compared the outcomes of radical lymphadenectomy of the mediastinum, including upper mediastinal lymphadenectomy, between patients with AEG and those with SCC. Read More

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http://dx.doi.org/10.1093/dote/doz002DOI Listing
February 2019

Intraluminal mesh erosion after prosthetic hiatoplasty: incidence, management, and outcomes.

Dis Esophagus 2019 Feb 22. Epub 2019 Feb 22.

Department of Surgery Hospital Clínico San Carlos, Madrid, Spain.

The purpose of the present study was to analyze the incidence, presentation, and treatment of mesh erosion into the esophagus or stomach after mesh hiatoplasty for primary or recurrent hiatal hernia. The study is a single-institution, retrospective cohort study. From November 2005 to December 2016, 122 patients consecutively underwent mesh hiatoplasty in our department, 91 during a primary surgery and 31 for a surgical revision. Read More

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http://dx.doi.org/10.1093/dote/doy131DOI Listing
February 2019

Liquid Nitrogen Spray Cryotherapy in Treatment of Barrett's Esophagus, where do we stand? A Systematic Review and Meta-Analysis.

Dis Esophagus 2019 Jan 31. Epub 2019 Jan 31.

Division of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, Utah, USA.

Radiofrequency ablation (RFA) is the preferred treatment option for Barrett's esophagus (BE) to achieve complete eradication (CE) of dysplasia (D), and intestinal metaplasia (IM). Cryotherapy, using liquid nitrogen (LNC), is a cold-induced tissue-injury technique option for the ablation of BE. We conducted a systematic review and meta-analysis to assess the overall efficacy and safety of LNC in the treatment of BE. Read More

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http://dx.doi.org/10.1093/dote/doy130DOI Listing
January 2019

Management of eosinophilic esophagitis is often discordant with guidelines and not patient-centered: results of a survey of gastroenterologists.

Dis Esophagus 2019 Jan 31. Epub 2019 Jan 31.

Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.

Published guidelines for the management of eosinophilic esophagitis (EoE) recommend an initial trial of proton pump inhibitors (PPI), histologic assessment for response to therapy, and tailoring treatments to patient needs and provider resources. Effectiveness studies directly comparing therapies are lacking, leaving a situation ripe for shared decision making. We aimed to assess gastroenterologists' adherence to guidelines and how they respond to EoE patients' preferences regarding management. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy133DOI Listing
January 2019
2 Reads

The impact of gastroesophageal reflux disease symptoms in scleroderma: effects on sleep quality.

Dis Esophagus 2019 Jan 31. Epub 2019 Jan 31.

Division of Gastroenterology and Hepatology.

Systemic scleroderma/sclerosis (SSc) is an autoimmune connective tissue disease, which can lead to esophageal motor dysfunction and gastroesophageal reflux disease (GERD). Nocturnal GERD symptoms may be associated with sleep disturbances, which in turn can drastically affect well-being and fatigue levels. We hypothesized that GERD symptoms would be associated with poorer sleep in patients with SSc. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy136DOI Listing
January 2019
6 Reads

A competing-risks nomogram and recursive partitioning analysis for cause-specific mortality in patients with esophageal neuroendocrine carcinoma.

Authors:
G Zhang B Wu X Wang J Li

Dis Esophagus 2019 Jan 31. Epub 2019 Jan 31.

Department of Thoracic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.

The objective of this study is to estimate the probability of cause-specific mortality using a competing-risks nomogram and recursive partitioning analysis in a large population-based cohort of patients with esophageal neuroendocrine carcinoma. The surveillance, epidemiology and end results database was used to identify 162 patients diagnosed with esophageal neuroendocrine carcinoma from 1998 to 2014. We estimated a cumulative incidence function for cause-specific mortality. Read More

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http://dx.doi.org/10.1093/dote/doy129DOI Listing
January 2019

Intensity-modulated radiotherapy at high-volume centers improves survival in patients with esophageal adenocarcinoma receiving trimodality therapy.

Dis Esophagus 2018 Dec 31. Epub 2018 Dec 31.

Department of Radiation Oncology, The warren Alpert Medical School of Brown university, Providence, USA.

The standard of care trimodality therapy for resectable locally advanced esophageal adenocarcinoma is complex and necessitates multidisciplinary care and expertise. In this work, it is hypothesized that facility clinical volume and utilization of intensity-modulated radiotherapy (IMRT) may influence outcomes. The National Cancer Data Base was queried for patients with cT1-4-N0-3 M0 esophageal adenocarcinoma undergoing trimodality therapy from 2004 to 2013 (n = 2445). Read More

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http://dx.doi.org/10.1093/dote/doy124DOI Listing
December 2018
1 Read

Validation of instruments for the assessment of dysphagia due to malignancy of the esophagus.

Dis Esophagus 2018 Dec 31. Epub 2018 Dec 31.

Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital.

The aim of the study was to validate the Watson scale, the Ogilvie scale, and the Goldschmid scale for assessment of dysphagia due to malignancy of the esophagus. After translation of the scales to Swedish, 35 patients with dysphagia due to esophageal malignancy were asked to participate. On day 1, patients were asked to fill in the questionnaires. Read More

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http://dx.doi.org/10.1093/dote/doy125DOI Listing
December 2018
1 Read

Preemptive endoluminal vacuum therapy to reduce anastomotic leakage after esophagectomy: a game-changing approach?

Dis Esophagus 2018 Dec 31. Epub 2018 Dec 31.

Department of Visceral and Transplant Surgery, University Hospital Zurich, Zurich, Switzerland.

Endoluminal vacuum therapy (EVT) is an accepted treatment for anastomotic leakage (AL) after esophagectomy. A novel concept is to use this technology in a preemptive setting, with the aim to reduce the AL rate and postoperative morbidity. Preemptive EVT (pEVT) was performed intraoperatively in 19 consecutive patients undergoing minimally invasive esophagectomy, immediately after completion of esophagogastrostomy. Read More

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http://dx.doi.org/10.1093/dote/doy126DOI Listing
December 2018
1 Read

The overall metastatic rate in early esophageal adenocarcinoma: long-time follow-up of surgically treated patients.

Dis Esophagus 2018 Dec 31. Epub 2018 Dec 31.

Department of Surgery I, Klinikum Darmstadt, Darmstadt, Germany.

The overall metastatic potential of surgically treated early esophageal adenocarcinoma has not been studied in detail. This paper therefore assessed lymph node metastases at surgery, loco regional and distant metastases, in order to assess the metastatic potential of early esophageal adenocarcinoma. Two hundred and seventeen patients (53 T1a, 164 T1b; median follow-ups 87 and 75 months, 187 males) diagnosed with early esophageal adenocarcinoma and treated with esophagectomy in our tertiary center's database between July 2000 and December 2015 were included. Read More

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http://dx.doi.org/10.1093/dote/doy127DOI Listing
December 2018
1 Read

Outcomes of octogenarians with esophageal cancer: an analysis of the National Cancer Database.

Dis Esophagus 2018 Dec 31. Epub 2018 Dec 31.

Department of Thoracic Medicine and Surgery, Temple University Hospital, Philadelphia, USA.

The optimal treatment of esophageal cancer in octogenarians is controversial. While the safety of esophagectomy has been demonstrated in elderly patients, surgery and multimodality therapy are still offered to a select group. Additionally, the long-term outcomes in octogenarians have not been thoroughly compared to those in younger patients. Read More

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http://dx.doi.org/10.1093/dote/doy128DOI Listing
December 2018
1 Read

Epidural analgesia after minimally invasive esophagectomy: efficacy and complication profile.

Dis Esophagus 2018 Dec 17. Epub 2018 Dec 17.

Department of Surgery, University Medical Center Utrecht, The Netherlands.

Adequate postoperative pain management is essential to facilitate uneventful recovery after esophagectomy. Although epidural analgesia is the gold standard, it is not satisfactory in all patients. The aim of this study is to describe the efficacy and complication profile of epidural analgesia after minimally invasive esophagectomy (MIE). Read More

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http://dx.doi.org/10.1093/dote/doy116DOI Listing
December 2018
1 Read

Reply to letter: Neoadjuvant chemoradiotherapy or chemotherapy for esophageal cancer: what is the current evidence?

Dis Esophagus 2018 Dec 17. Epub 2018 Dec 17.

Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Theme Cancer, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1093/dote/doy101DOI Listing
December 2018
1 Read

Efficacy of triamcinolone-soaked polyglycolic acid sheet plus fully covered metal stent for preventing stricture formation after large esophageal endoscopic submucosal dissection.

Dis Esophagus 2019 Feb;32(2)

Department of Gastroenterology, Chinese PLA General Hospital, Beijing, China.

Esophageal stricture is a major problem for patients with large superficial esophageal squamous cell neoplasms (SESCNs) after endoscopic submucosal dissection (ESD). Although many measures could be used as prophylaxis for post-ESD strictures, a well-accepted method has not yet been established. We propose using a triamcinolone-soaked polyglycolic acid sheet plus fully covered metal stent (TS-PGA+FCMS) as a novel method to prevent stricture formation after large esophageal ESD. Read More

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http://dx.doi.org/10.1093/dote/doy121DOI Listing
February 2019
1 Read

Evolution of the surgical technique of minimally invasive Ivor-Lewis esophagectomy: description according to the IDEAL framework-but which IDEAL stage?

Authors:
A Hirst P McCulloch

Dis Esophagus 2018 Dec 17. Epub 2018 Dec 17.

IDEAL Collaboration, University of Oxford.

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http://dx.doi.org/10.1093/dote/doy122DOI Listing
December 2018
1 Read

Effervescent agents in acute esophageal food impaction.

Dis Esophagus 2018 Dec 17. Epub 2018 Dec 17.

Division of Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, Arizona, USA.

Acute esophageal food impaction (AEFI) occurs frequently. Few data are published describing the use of effervescent agents (EAs) for treatment of AEFI. We aimed to evaluate the effectiveness, cost, and safety of EAs in the treatment of AEFI. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy117DOI Listing
December 2018
8 Reads

Does DeMeester score still define GERD?

Dis Esophagus 2018 Dec 17. Epub 2018 Dec 17.

Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, USA.

Gastroesophageal reflux disease (GERD) clinical presentation may encompass a myriad of symptoms that may mimic other esophageal and extra-esophageal diseases. Thus, GERD diagnosis by symptoms only may be inaccurate. Upper digestive endoscopy and barium esophagram may also be misleading. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy118DOI Listing
December 2018
14 Reads

Intraoperative pyloric botulinum toxin injection during Ivor-Lewis gastroesophagectomy to prevent delayed gastric emptying.

Dis Esophagus 2018 Dec 17. Epub 2018 Dec 17.

Peninsula Oesophago-gastric Centre, University Hospitals Plymouth NHS Trust, united Kingdom.

Delayed gastric emptying (DGE) is a common morbidity that affects 10%-50% of Ivor-Lewis gastroesophagectomy (ILGO) patients. DGE management is variable with no gold standard prevention or treatment. We conducted a study to assess the effectiveness of intraoperative pyloric botulinum toxin injection in preventing DGE. Read More

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http://dx.doi.org/10.1093/dote/doy112DOI Listing
December 2018
2 Reads

Author's response regarding manuscript 'Evolution of the surgical technique of minimally invasive Ivor-Lewis esophagectomy: description according to the IDEAL framework'.

Dis Esophagus 2019 Feb;32(2)

Department of Surgery, Radboud University Medical Centre, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1093/dote/doy123DOI Listing
February 2019
1 Read

An anatomical hypothesis: a "concentric-structured model" for the theoretical understanding of the surgical anatomy in the upper mediastinum required for esophagectomy with radical mediastinal lymph node dissection.

Dis Esophagus 2018 Dec 17. Epub 2018 Dec 17.

Department of Esophageal Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Understanding the surgical anatomy is the key to reducing surgical invasiveness especially in the upper mediastinal dissection for esophageal cancer, which is supposed to have a significant impact on curability and morbidity. However, there is no theoretical recognition regarding the surgical anatomy required for esophagectomy, although the surgical anatomy in abdominal digestive surgery has been developed on the basis of embryological findings of intestinal rotation and fusion fascia. Therefore, we developed a hypothesis of a 'concentric-structured model' of the surgical anatomy in the upper mediastinum based on human embryonic development. Read More

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http://dx.doi.org/10.1093/dote/doy119DOI Listing
December 2018
1 Read

Normal radiological lymph node appearance in the thorax.

Dis Esophagus 2018 Dec 17. Epub 2018 Dec 17.

Department of Surgical Sciences.

Modern treatment of esophageal cancer is multimodal and highly dependent on a detailed diagnostic assessment of clinical stage, which includes nodal stage. Clinical appraisal of nodal stage is highly dependent on knowledge of normal radiological appearance, information of which is scarce. We aimed to describe lymph node appearance on computed tomography (CT) investigations in a randomly selected cohort of healthy subjects. Read More

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http://dx.doi.org/10.1093/dote/doy120DOI Listing
December 2018
1 Read

Wide-area transepithelial sampling with computer-assisted 3-dimensional analysis (WATS) markedly improves detection of esophageal dysplasia and Barrett's esophagus: analysis from a prospective multicenter community-based study.

Dis Esophagus 2018 Dec 12. Epub 2018 Dec 12.

Gastroenterology, New York University Langone Medical Center, New York, NY, USA.

The 4-quadrant forceps biopsy (FB) protocol for identifying Barrett's esophagus (BE) and esophageal dysplasia (ED) suffers from poor sensitivity due to significant sampling error. We investigated the benefit of wide-area transepithelial sampling with 3-dimensional computer-assisted analysis (WATS) used adjunctively to the combination of random and targeted FB in the detection of ED, and as a secondary outcome, BE. In this multicenter prospective trial, community endoscopists at 21 sites utilized WATS as an adjunct to both targeted and random FB in patients undergoing BE screening and surveillance. Read More

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http://dx.doi.org/10.1093/dote/doy099DOI Listing
December 2018
5 Reads

Association of preoperative inflammation-based prognostic score with survival in patients undergoing salvage esophagectomy.

Dis Esophagus 2018 Jul 26. Epub 2018 Jul 26.

Department of Gastrointestinal Surgery, Graduate School of Medicine, the University of Tokyo.

Salvage esophagectomy (SALV) is potentially beneficial for patients with residual or relapsed esophageal carcinoma after definitive chemoradiotherapy (dCRT), although preoperatively identifying good candidates for SALV remains difficult. We investigated the prognostic impacts of inflammatory and nutritional status in patients undergoing SALV after dCRT. Forty-seven SALV patients were retrospectively reviewed, of whom 46 (98%) had squamous cell carcinoma and 1 (2%) adenocarcinoma. Read More

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http://dx.doi.org/10.1093/dote/doy066DOI Listing
July 2018
1 Read

Preoperative endoscopic pyloric balloon dilatation decreases the rate of delayed gastric emptying after Ivor-Lewis esophagectomy.

Dis Esophagus 2018 Dec 1. Epub 2018 Dec 1.

Department of General-, Visceral-, and Transplant Surgery, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Delayed gastric emptying (DGE) after Ivor-Lewis esophagectomy occurs postoperatively in up to 50% of the patients. This pyloric dysfunction can lead to severe secondary complications postoperatively such as early aspiration, pneumonia or may even have an impact on anastomotic healing and therefore leakage. Early detection of DGE is essential to prevent further complications. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy097DOI Listing
December 2018
11 Reads

Associated risks of proton pump inhibitors and their influence on prescribing habits: is change truly warranted?

Authors:
A Dua M Venu

Dis Esophagus 2018 Nov 28. Epub 2018 Nov 28.

Loyola University Medical Center, Division of Gastroenterology , Stritch School of Medicine, Maywood, Illinois, USA.

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy103DOI Listing
November 2018
2 Reads

A biomarker panel predicts progression of Barrett's esophagus to esophageal adenocarcinoma.

Dis Esophagus 2019 Jan;32(1)

Medical Research Council Cancer Unit, Hutchison-MRC Research Center, University of Cambridge,Cambridge,United Kingdom.

Progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC) is uncommon but the consequences are serious. Predictors of progression are essential to optimize resource utilization. This study assessed the utility of a promising panel of biomarkers applicable to routine paraffin embedded biopsies (FFPE) to predict progression of BE to EAC in a large population-based, nested case-control study. Read More

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http://dx.doi.org/10.1093/dote/doy102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303732PMC
January 2019
7 Reads

Enhanced recovery protocol in esophagectomy, is it really worth it? A cost analysis related to team experience and protocol compliance.

Dis Esophagus 2018 Nov 28. Epub 2018 Nov 28.

Division of General and Upper Gastrointestinal Surgery, Department of Surgery.

Application of enhanced recovery protocols (ERP) in esophageal surgery seems to lead an advantage in terms of length of hospital staying and outcomes, but only few data exist on its cost effectiveness. Previous literature analyzed pre- and post-ERP groups, finding a cost reduction with the introduction of the pathway. We aimed to study the influence on costs of accumulating experience and compliance in an ERP group. Read More

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http://dx.doi.org/10.1093/dote/doy114DOI Listing
November 2018
2 Reads

Outcomes of nutritional jejunostomy in the curative treatment of esophageal cancer.

Dis Esophagus 2018 Nov 28. Epub 2018 Nov 28.

Surgical Care Science, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Substantial weight loss and eating problems are common before and after esophagectomy for cancer. The use of jejunostomy might prevent postoperative weight loss, but studies evaluating other outcomes are scarce. This study aims to assess the influence of jejunostomy on postoperative health-related quality of life (HRQOL), complications, reoperation, hospital stay, and survival. Read More

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http://dx.doi.org/10.1093/dote/doy113DOI Listing
November 2018
12 Reads

Preoperative sarcopenia is a predictor of poor prognosis of esophageal cancer after esophagectomy: a comprehensive systematic review and meta-analysis.

Dis Esophagus 2018 Nov 28. Epub 2018 Nov 28.

Department of Thoracic Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

The impact of preoperative sarcopenia on long-term survival of esophageal cancer patients after esophagectomy remains unclear. We conducted an updated meta-analysis focusing on current topic comprehensively. We systematically searched relevant studies investigating the impact of preoperative sarcopenia on survival of patients with surgically treated esophageal cancer in PubMed, Embase, and Web of Science up to July 20, 2018. Read More

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http://dx.doi.org/10.1093/dote/doy115DOI Listing
November 2018
3 Reads

Does the Pittsburgh Severity Score predict outcome in esophageal perforation?

Dis Esophagus 2019 Feb;32(2)

Department of Upper Gastrointestinal Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Esophageal perforation is an uncommon and challenging surgical emergency associated with high rates of morbidity and mortality. At present, no consensus exists on optimal management of the condition. The Pittsburgh Severity Score (PSS) is a tool intended to stratify perforation severity and guide treatment. Read More

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http://dx.doi.org/10.1093/dote/doy109DOI Listing
February 2019
2 Reads

Does robot-assisted minimally invasive esophagectomy really have the advantage of lymphadenectomy over video-assisted minimally invasive esophagectomy in treating esophageal squamous cell carcinoma? A propensity score-matched analysis based on short-term outcomes.

Dis Esophagus 2018 Nov 28. Epub 2018 Nov 28.

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.

This study aims to investigate advantages of robot-assisted minimally invasive esophagectomy (RAMIE) over video-assisted minimally invasive esophagectomy (VAMIE) in treating esophageal squamous cell carcinoma by applying propensity score-matched analysis. From April 2016 to January 2018, consecutive patients undergoing a McKeown RAMIE or VAMIE for esophageal squamous cell carcinoma were prospectively included for analysis. Baseline data, pathological findings, and short-term outcomes of the two groups (RAMIE group and VAMIE group) were collected and compared. Read More

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http://dx.doi.org/10.1093/dote/doy110DOI Listing
November 2018
10 Reads

National guidelines may reduce socioeconomic disparities in treatment selection for esophageal cancer.

Dis Esophagus 2018 Nov 28. Epub 2018 Nov 28.

Department of Surgery, Division of Thoracic Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

The 2011 National Comprehensive Cancer Network guidelines first incorporated the results of the landmark CROSS trial, establishing induction therapy (chemotherapy ± radiation) and surgery as the treatment standard for locoregional esophageal cancer in the United States. The effect of guideline publication on socioeconomic status (SES) inequalities in cancer treatment selection remains unknown.Patients diagnosed with Stage II/III esophageal cancer between 2004 and 2013 who underwent curative treatment with definitive chemoradiation or multimodality treatment (induction and surgery) were identified from the Surveillance, Epidemiology and End Results (SEER)-Medicare registry. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy111DOI Listing
November 2018
7 Reads

Sarcopenia: an unneglectable nutritional status in oncological esophagectomy.

Authors:
H-Y Deng L Hou P Zha

Dis Esophagus 2018 Nov 28. Epub 2018 Nov 28.

Department of Endocrinology, West China Hospital, Sichuan University, Chengdu, China.

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http://dx.doi.org/10.1093/dote/doy108DOI Listing
November 2018
1 Read

Endoscopic dilatation improves long-term dysphagia following head and neck cancer therapies: a randomized control trial.

Dis Esophagus 2018 Nov 20. Epub 2018 Nov 20.

Department of Gastroenterology and Hepatology.

Long-term pharyngeal dysphagia is a common complication following head and neck cancer (HNC) therapies. High-level evidence for pharyngoesophageal junction (POJ) dilatation as a treatment in this population is lacking. We aimed to evaluate the safety and efficacy of POJ dilatation in dysphagic HNC survivors. Read More

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http://dx.doi.org/10.1093/dote/doy087DOI Listing
November 2018
10 Reads

Oral delivery of fluticasone powder improves esophageal eosinophilic inflammation and symptoms in adults with eosinophilic esophagitis.

Dis Esophagus 2018 Dec;31(12)

Department of Medicine, Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Topical steroids are the primary medical therapy for eosinophilic esophagitis (EoE). Current steroid formulations are used off-label and designed for airway delivery. It is known that the efficacy of topical steroids depends on drug-mucosal contact time, which is related to its formulation. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy098DOI Listing
December 2018
20 Reads

Neoadjuvant chemoradiotherapy or chemotherapy for esophageal cancer: what is the current evidence?

Dis Esophagus 2019 Feb;32(2)

Lung cancer center, and West China Hospital, Sichuan University, Chengdu, China.

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http://dx.doi.org/10.1093/dote/doy100DOI Listing
February 2019
2 Reads

Pneumatic dilation versus laparoscopic Heller's myotomy in the treatment of achalasia: systematic review and meta-analysis based on randomized controlled trials.

Dis Esophagus 2019 Feb;32(2)

Gastroenterology Department, Endoscopy Unit, Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil.

Achalasia is a primary esophageal motor disorder with a variety of causes. It is most common in Central and South America, where Chagas disease is endemic. In addition to the infectious etiology, achalasia can be idiopathic, autoimmune, or drug induced. Read More

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http://dx.doi.org/10.1093/dote/doy105DOI Listing
February 2019
3 Reads

Long-term weight development after esophagectomy for cancer-comparison between open Ivor-Lewis and minimally invasive surgical approaches.

Dis Esophagus 2018 Oct 22. Epub 2018 Oct 22.

Division of Surgery, Department of Clinical Science, Technology and Intervention (CLINTEC), Karolinska Institutet.

Esophagectomy is an extensive procedure with severe postoperative effects. It can be assumed that the greater the trauma, the longer the nutritional recovery. This retrospective observational single-center cohort study compared weight development after esophagectomy with open and minimally invasive techniques. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy075DOI Listing
October 2018
10 Reads

Texture analysis of computed tomography data using morphologic and metabolic delineation of esophageal cancer-relation to tumor type and neoadjuvant therapy response.

Dis Esophagus 2018 Oct 8. Epub 2018 Oct 8.

Department of Diagnostic Radiology, Centre for Digestive Diseases, Karolinska Institutet, CLINTEC, Karolinska University Hospital, Stockholm, Sweden.

The prognostic values of image-based tumor texture analysis based on computed tomography (CT) and of limiting the segmented tumor volume to metabolically active regions using fludeoxyglucose-positron emission tomography (FDG-PET) were studied in 25 patients with esophageal adenocarcinoma and 11 patients with squamous cell carcinoma. The aims of this study are to describe their CT-image-based texture characteristics before and after neoadjuvant therapy and to evaluate whether limiting the examined tumor volume to metabolically active regions detected with FDG-PET image data would further improve their value. Textural parameters (homogeneity, energy, entropy, contrast, and correlation) based on gray-level co-occurrence matrices (GLCM) were calculated for 3D volumes of segmented esophageal tumors before and after neoadjuvant chemotherapy or radiochemotherapy. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy096DOI Listing
October 2018
2 Reads

Infections of the esophagus: an update on risk factors, diagnosis, and management.

Dis Esophagus 2018 Dec;31(12)

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

Infectious esophagitis is a leading cause of esophagitis worldwide. While esophageal infections have traditionally been associated with immunocompromised patients, these disorders are becoming increasingly recognized in immunocompetent individuals. The three most common etiologies of infectious esophagitis are Candida, herpes simplex virus, and cytomegalovirus. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy094DOI Listing
December 2018
15 Reads

Hybrid transgastric approach for the treatment of gastroesophageal junction pathologies.

Dis Esophagus 2019 Feb;32(2)

IHU-Strasbourg, Institute of Image-Guided Surgery, Strasbourg, France.

Flexible endoscopy has evolved to the point that it includes many endoluminal procedures that once required open or laparoscopic surgery, for instance, antireflux surgery, pyloromyotomy, mucosal and submucosal tumor resections, and even full-thickness resection. However, these procedures remain technically demanding due to flexible technology issues: difficult imaging, limited energy devices, lack of staplers, unsatisfactory suturing abilities, and so on. Transgastric laparoscopy or hybrid laparoscopy/flex endoscopy has been described for almost two decades as an alternative to a pure endoluminal approach, mainly for pancreatic pseudocyst drainage and full-thickness and mucosal resection of various lesions. Read More

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http://dx.doi.org/10.1093/dote/doy095DOI Listing
February 2019
2 Reads

Effect of preoperative inspiratory muscle training on physical functioning following esophagectomy.

Dis Esophagus 2019 Feb;32(2)

Department of Surgery, St. James' Hospital, Dublin, Ireland.

This study aims to examine the effect of preoperative inspiratory muscle training (IMT) on pre- and postoperative functional exercise performance in patients undergoing esophagectomy. A subcohort of patients recruited to the PREPARE randomized control trial were studied. Following evaluation of respiratory muscle function (spirometry, maximum inspiratory pressure (MIP), and inspiratory muscle endurance), postoperative mobilization (accelerometry) and postoperative physical functioning (6-minute walk test (6MWT)), participants scheduled for esophagectomy were randomly assigned to either 2 weeks of preoperative IMT or a control group. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361819PMC
February 2019
12 Reads

Food impaction: etiology over 35 years and association with eosinophilic esophagitis.

Dis Esophagus 2018 Oct 8. Epub 2018 Oct 8.

Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

With the emergence of eosinophilic esophagitis (EoE) as a common cause of food impaction (FI) and a presumed increase in incidence of EoE in the population, the effect on the incidence of FI has not been well described. The aim of this study is to describe the incidence of FI and endoscopic findings in these patients and the association with EoE. A population-based retrospective chart review of the Rochester Epidemiology Project database was performed to identify all patients within Olmsted County that presented with FI from 1976 to 2012. Read More

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http://dx.doi.org/10.1093/dote/doy093DOI Listing
October 2018
1 Read

Radiotherapy improves the survival of patients with metastatic esophageal squamous cell carcinoma: a propensity score matched analysis of Surveillance, Epidemiology, and End Results database.

Dis Esophagus 2019 Jan;32(1)

Cancer Center.

The survival advantage of radiotherapy (RT) for patients with metastatic esophagus cancer has not been adequately evaluated. This study aims to find out the role of RT for metastatic esophagus cancer and to find the different effect for RT to esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC). This study included 5,970 metastatic esophagus cancer patients from the Surveillance, Epidemiology, and End Results (SEER) database, registered from January 2004 to December 2013. Read More

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https://academic.oup.com/dote/article/doi/10.1093/dote/doy07
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http://dx.doi.org/10.1093/dote/doy074DOI Listing
January 2019
2 Reads

Evolution of the surgical technique of minimally invasive Ivor-Lewis esophagectomy: description according to the IDEAL framework.

Dis Esophagus 2018 Sep 21. Epub 2018 Sep 21.

Department of Surgery, Radboud University Medical Centre.

Totally minimally invasive Ivor-Lewis esophagectomy (Ivor Lewis TMIE) is a technically challenging procedure and is associated with a learning curve. Refinement of surgical technique is an important part of this learning curve. However, detailed descriptions of these refinements according to the idea, development, exploration, assessment, and long-term follow-up (IDEAL) framework are lacking and this study was undertaken to fill this knowledge gap. Read More

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http://dx.doi.org/10.1093/dote/doy079DOI Listing
September 2018
12 Reads

Neoadjuvant chemotherapy with irinotecan and nedaplatin in a single cycle followed by esophagectomy on cT4 resectable esophageal squamous cell carcinoma: a prospective nonrandomized trial for short-term outcomes.

Dis Esophagus 2018 Aug 27. Epub 2018 Aug 27.

Department of Cardiothoracic Surgery, Affiliated Hospital of North Sichuan Medical College.

Neoadjuvant chemotherapy (NAC) significantly extends survival in advanced esophageal squamous cell carcinoma (ESCC), but the short-term outcomes for cT4 ESCC remain controversial. Many NAC regimens have been previously reported, although no study has reported a regimen of irinotecan and nedaplatin for cT4 potential resectable ESCC. We evaluated the short-term outcomes of NAC with irinotecan and nedaplatin in a single cycle followed by esophagectomy on cT4 resectable ESCC. Read More

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http://dx.doi.org/10.1093/dote/doy080DOI Listing
August 2018
1 Read

Sarcopenia, the depletion of muscle mass, an independent predictor of respiratory complications after oncological esophagectomy.

Dis Esophagus 2018 Sep 17. Epub 2018 Sep 17.

Department of Surgery, National Center for Global Health and Medicine, Tokyo, Japan.

Surgery for esophageal carcinoma is known to be associated with high morbidity. Recent studies have reported a correlation of nutritional and inflammatory parameters with postoperative course. This study aims to clarify the risk factors for operative morbidity after resection of esophageal carcinoma. Read More

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http://dx.doi.org/10.1093/dote/doy092DOI Listing
September 2018
1 Read

A crosssectional analysis of Facebook comments to study public perception of a new diagnostic test called the Cytosponge.

Dis Esophagus 2019 Jan;32(1)

MRC Cancer Unit, University of Cambridge, London, UK.

Social media provides a useful platform for informal discussions about healthcare. Acceptability is key to the uptake of diagnostic devices and this can be difficult to gauge from questionnaires and qualitative studies. The aim of this study is to investigate whether Facebook could be used to gauge public perception toward uptake of a new diagnostic test for Barrett's esophagus called the Cytosponge. Read More

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http://dx.doi.org/10.1093/dote/doy085DOI Listing
January 2019
1 Read

Do dysplastic proximal resection margins predict the risk of anastomotic recurrence and overall survival in patients with esophageal squamous cell carcinoma?

Dis Esophagus 2018 Sep 17. Epub 2018 Sep 17.

Division of Thoracic Surgery, Chang Gung Memorial Hospital-Linkou, College of Medicine, Taoyuan, Taiwan.

Positive proximal resection margins are strongly associated with anastomotic recurrence in esophageal cancer. However, the prognostic significance of dysplastic proximal resection margins remains unclear. The aim of this study is to investigate whether the dysplastic proximal resection margin can predict anastomotic recurrence and overall survival in patients with esophageal squamous cell carcinoma. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
Publisher Site
http://dx.doi.org/10.1093/dote/doy090DOI Listing
September 2018
3 Reads

Pulmonary diffusion capacity predicts major complications after esophagectomy for patients with esophageal cancer.

Dis Esophagus 2018 Sep 17. Epub 2018 Sep 17.

Department of Surgery, University Medical Center Utrecht, Utrecht University, The Netherlands.

A reduced forced expiratory volume in one second (FEV1) is a well-recognized risk factor for complications after esophagectomy. Lung diffusing capacity for carbon monoxide (DLCO) is not routinely integrated in the risk assessment of esophagectomy. The aim of this study is to evaluate the association of preoperative pulmonary function tests with major postoperative complications after esophagectomy for cancer. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy082DOI Listing
September 2018
14 Reads