6,290,681 results match your criteria Diseases of Tetrapyrrole Metabolism - Refsum Disease and the Hepatic Porphyrias

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[Infectious Disease Consultations in Patients with Staphylococcus Aureus Bacteraemia - a Retrospective Observational Study at Jena University Hospital].

Dtsch Med Wochenschr 2018 Oct 14;143(21):e2. Epub 2019 Jan 14.

Institut für Infektionsmedizin und Krankenhaushygiene, Universitätsklinikum Jena.

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http://dx.doi.org/10.1055/a-0816-9947DOI Listing
October 2018

Association of ACE I/D Polymorphism with Risk of Diabetes in Cardiovascular Disease Patients.

Exp Clin Endocrinol Diabetes 2019 Jan 14. Epub 2019 Jan 14.

Diabetes and Cardio-Metabolic Disorders Lab, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan.

Angiotensin converting enzyme (ACE), as part of renin angiotensin aldosterone system, is involved in blood pressure regulation and control several physiological functions. Insertion/Deletion (I/D) polymorphism of has pronounced effects on development of metabolic diseases like diabetes, cardiovascular diseases (CVDs) and hypertension. However, association of I/D polymorphism with risk of diabetes in CVD patients is not known. Read More

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http://dx.doi.org/10.1055/a-0824-6515DOI Listing
January 2019

Success of immune checkpoint blockade therapies - mechanisms and implications for hepatology.

Z Gastroenterol 2019 Jan 14;57(1):74-86. Epub 2019 Jan 14.

Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, University Medical Center Freiburg, Faculty of Medicine, Germany.

The success of immune modulation by checkpoint blockade approaches is currently transforming oncology, with high and long-lasting tumor responses in patients with advanced disease across many cancer entities. Rooted in the reinvigoration of adaptive antitumor immune responses through disinhibition of negative feedback pathways, these approaches are particularly effective in patients with significant preexisting T cell responses in tumors with high neoantigen load. While promising data is starting to emerge from clinical trials in liver cancer patients, the underlying immunobiology remains poorly understood. Read More

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http://dx.doi.org/10.1055/a-0805-6936DOI Listing
January 2019
2 Reads

Case report: a rare cause of a hypervascular nodule in a noncirrhotic liver.

Z Gastroenterol 2019 Jan 14;57(1):57-60. Epub 2019 Jan 14.

Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.

A 37-year-old male patient with Crohn's disease and multiple liver hemangiomas was referred to our hospital for an atypical hypervascular hepatic lesion detected on an external magnetic resonance imaging (MRI) scan. The patient was otherwise well and had no history of any liver disease. Liver values and tumor markers were normal. Read More

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http://dx.doi.org/10.1055/a-0755-2478DOI Listing
January 2019

[The role of Cytochrom P4502E1 in Alcoholic Liver Disease and alcohol mediated carcinogenesis].

Z Gastroenterol 2019 Jan 14;57(1):37-45. Epub 2019 Jan 14.

Department of Medicine and Liver Diseases, Salem Medical Center, University of Heidelberg, Germany.

Various factors are involved in the pathogenesis of alcoholic liver disease (ALD) and ethanol-mediated carcinogenesis. In addition to genetic, epigenetic and immunologic mechanisms, acetaldehyde-associated toxicity, oxidative stress as well as cytokine-mediated inflammation are of major importance. Oxidative stress, with the generation of reactive oxygen species (ROS), develops either in inflammation (alcoholic hepatitis) or during oxidation of ethanol via cytochrome P4502E1 (CYP2E1). Read More

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http://dx.doi.org/10.1055/a-0784-8815DOI Listing
January 2019

[Utilisation of Psychotherapeutic Assistance By Diabetes Patients with a History of Migration].

Psychother Psychosom Med Psychol 2019 Jan 14. Epub 2019 Jan 14.

Klinik für Psychosomatische Medizin und Psychotherapie, LVR Klinikum, Kliniken der Heinrich-Heine Universität Düsseldorf.

According to available studies, migrant patients are more often affected by diabetes mellitus and comorbid psychological complaints than patients without a history of migration. Less is known about whether these patients receive psychotherapeutic assistance for their complaints and which factors may influence the utilisation of psychotherapy in this patient group. We sought to answer these questions by using culture sensitive material which included a screening for depressive symptoms (the Patient Health Questionnaire) and sociodemographic items. Read More

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http://dx.doi.org/10.1055/a-0754-2459DOI Listing
January 2019

Indwelling Pleural Catheter Placement for Nonmalignant Pleural Effusions.

Semin Respir Crit Care Med 2018 Dec 14;39(6):713-719. Epub 2019 Jan 14.

Division of Pulmonary, Critical Care and Sleep Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut.

Pleural effusions account for significant symptoms and morbidity. Recent studies demonstrate a high mortality in patients with "benign" pleural effusions, now better characterized as nonmalignant pleural effusions (NMPEs) based on their prognosis. The most common nonmalignant clinical conditions with recurrent pleural effusions are congestive heart failure and hepatic hydrothorax, although many other diseases exist in isolation or as comorbid conditions. Read More

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http://dx.doi.org/10.1055/s-0038-1676648DOI Listing
December 2018

Thoracoscopy: Advances and Increasing Role for Interventional Pulmonologists.

Authors:
Pyng Lee Erik Folch

Semin Respir Crit Care Med 2018 Dec 14;39(6):693-703. Epub 2019 Jan 14.

Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Thoracoscopy is an increasingly common procedure that provides significant clinical information and therapeutic applications. The procedure allows the physician to biopsy the parietal pleura under direct visualization with high accuracy. In addition, one can drain pleural fluid, place a chest tube in a precise location, and perform poudrage pleurodesis. Read More

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http://dx.doi.org/10.1055/s-0038-1676978DOI Listing
December 2018

Tracheobronchomalacia and Excessive Dynamic Airway Collapse: Medical and Surgical Treatment.

Semin Respir Crit Care Med 2018 Dec 14;39(6):667-673. Epub 2019 Jan 14.

Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Excessive central airway collapse (ECAC) is characterized by excessive narrowing of the airway lumen during exhalation leading to dyspnea, cough, mucostasis, recurrent respiratory infections, and poor quality of life. Tracheobronchomalacia and excessive dynamic airway collapse are heterogeneous entities of ECAC and are characterized by a diverse nonspecific symptom profile. Although the pathophysiology of airway mechanics as well as morphology in both entities is different, current evidence so far shows no practical benefit in making such distinction since both have similar symptoms and the diagnostic and therapeutic work-ups are the same. Read More

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http://dx.doi.org/10.1055/s-0038-1676571DOI Listing
December 2018

Linear Endobronchial Ultrasound: What's New?

Authors:
Tao He Atul C Mehta

Semin Respir Crit Care Med 2018 Dec 14;39(6):649-660. Epub 2019 Jan 14.

Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio.

Since its advent more than a decade ago, real-time linear endobronchial ultrasound (EBUS) guided transbronchial needle aspiration has revolutionized the diagnosis and staging of nonsmall cell lung cancer (NSCLC), and has become the standard of care with widespread acceptance. It is also extensively used to diagnose other disease entities such as malignancy besides NSCLC, benign diseases, or infectious processes. Ancillary studies have shown its superior safety profile and cost-effectiveness. Read More

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http://dx.doi.org/10.1055/s-0038-1676646DOI Listing
December 2018

Transbronchial Cryobiopsies.

Semin Respir Crit Care Med 2018 Dec 14;39(6):637-648. Epub 2019 Jan 14.

Division of Pulmonary, Critical Care Medicine, Clinical Immunology, and Allergy, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.

Transbronchial lung cryobiopsy (TBLCB) is a relatively new and promising technique for the acquisition of larger amounts of higher quality lung tissue for the diagnosis of lung diseases. There is a growing body of literature describing a diagnostic yield comparable to surgical lung biopsy with a favorable safety profile. Due to its advantages TBLCB has garnered significant interest with more institutions beginning to adopt this technique. Read More

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http://dx.doi.org/10.1055/s-0038-1676645DOI Listing
December 2018

Correction: Optical Imaging Technology: A Useful Tool to Identify Remission in Cushing Disease After Surgery.

Horm Metab Res 2019 Jan 14. Epub 2019 Jan 14.

Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.

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http://dx.doi.org/10.1055/a-0828-9509DOI Listing
January 2019
1 Read

The Effects of Diabetes and High-Fat Diet on Polymodal Nociceptor and Cold Thermoreceptor Nerve Terminal Endings in the Corneal Epithelium.

Invest Ophthalmol Vis Sci 2019 Jan;60(1):209-217

Department of Anatomy and Neuroscience, The University of Melbourne, Melbourne, Victoria, Australia.

Purpose: There is a substantial body of evidence indicating that corneal sensory innervation is affected by pathology in a range of diseases. However, there are no published studies that have directly assessed whether the nerve fiber density of the different subpopulations of corneal sensory neurons are differentially affected. The present study explored the possibility that the intraepithelial nerve fiber density of corneal polymodal nociceptors and cold thermoreceptors are differentially affected in mice fed with a high-fat high cholesterol (HFHC; 21% fat, 2% cholesterol) diet and in those that also have diabetes. Read More

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http://dx.doi.org/10.1167/iovs.18-25788DOI Listing
January 2019

Molecular epidemiology and expression of capsular polysaccharides in Staphylococcus aureus clinical isolates in the United States.

PLoS One 2019 14;14(1):e0208356. Epub 2019 Jan 14.

Pfizer Vaccine Research and Development, Pearl River, New York, United States of America.

Staphylococcus aureus capsular polysaccharides (CP) are important virulence factors under evaluation as vaccine antigens. Clinical S. aureus isolates have the biosynthetic capability to express either CP5 or CP8 and an understanding of the relationship between CP genotype/phenotype and S. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208356PLOS
January 2019
1 Read

Haemophagocytic syndrome in Systemic Lupus Erythematosus - clues to an early diagnosis.

Acta Reumatol Port 2018 Oct-Dec;43(4):318-320

Centro Hospitalar São João.

Macrophage activation syndrome (MAS) is a rare life-threatening condition that involves excessive activation of inflammatory cells and overproduction of different cytokines. It is characterized by persistent fever, hepatosplenomegaly, cytopenias and coagulopathy. Other prominent features are hyperferritinemia and findings of activated macrophages in haemopoietic organs, often associated with multi-organ impairment. Read More

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January 2019

Mickey mouse sign - a rare and specific finding of Paget's disease of bone.

Acta Reumatol Port 2018 Oct-Dec;43(4):314-315

Centro Hospitalar Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.

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January 2019

Neuromuscular manifestations of primary biliary cholangitis: two case reports and literature review.

Acta Reumatol Port 2018 Oct-Dec;43(4):304-308

Primary biliary cholangitis (PBC) is a rare chronic disease, characterized by progressive cholestasis that could end in end-stage liver disease. Its diagnosis is based in the presence of a cholestatic pattern and antimitochondrial antibodies. Neurological complications of PBC are unusual, but there are descriptions of association with myopathies and neuropathies, being polymyositis the most frequent. Read More

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January 2019

Determinants of non-nociceptive pain in Rheumatoid Arthritis.

Acta Reumatol Port 2018 Oct-Dec;43(4):291-303

BG University Hospital Bergmannsheil GmbH.

Introduction: Features suggestive of neuropathic pain (NP) have been described in RA in addition to nociceptive pain. We aimed to determine the clinical predictors of NP in RA patients and study its association with radiographic structural damage.

Methods: Cross-sectional study was performed with RA patients followed at our Rheumatology department. Read More

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January 2019

The association between clinically suspect arthralgia and adipokines in obese patients.

Acta Reumatol Port 2018 Oct-Dec;43(4):284-290

Adnan Menderes University.

Objective: Obesity is a moderate low-grade chronic inflammatory condition. The cause of low-grade inflammation in obese patients who have clinically suspect arthralgia (CSA) may be the subject of debate in clinical practice. Our aim is to determine whether inflammation is associated with obesity or rheumatic disease, and the association between leptin, chemerin, visfatin and inflammatory markers in obese patients with/without musculoskeletal symptoms. Read More

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January 2019

Th17 pathway genes polymorphisms in Algerian patients with systemic sclerosis.

Acta Reumatol Port 2018 Oct-Dec;43(4):269-278

Objective: TH17 cells have involved in the pathogenesis of several autoimmune diseases including systemic sclerosis (SSc). The aim of our study was to investigate an association of IL-17A, IL-17F, IL-21, IL-23R and STAT3 genes with SSc susceptibility, and clinical and immunological phenotypes.

Patients And Methods: The case-control study included 136 patients suffering from SSc and 317 healthy controls of the Algerian population. Read More

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January 2019

Inactivating PTH/PTHrP Signaling Disorders.

Front Horm Res 2019 19;51:147-159. Epub 2018 Nov 19.

Pseudohypoparathyroidism (PHP), pseudo-PHP, acrodysostosis, and progressive osseous heteroplasia are heterogeneous disorders characterized by physical findings, differently associated in each subtype, including short bones, short stature, a stocky build, ectopic ossifications (features associated with Albright's hereditary osteodystrophy), as well as laboratory abnormalities consistent with hormone resistance, such as hypocalcemia, hyperphosphatemia, and elevated parathyroid hormone (PTH) and thyroid-stimulating hormone levels. All these disorders are caused by impairments in the cAMP-mediated signal transduction pathway and, in particular, in the PTH/PTHrP signaling pathway: the main subtypes of PHP and related disorders are caused by de novo or autosomal dominantly inherited inactivating genetic mutations, and/or epigenetic, sporadic, or genetic-based alterations within or upstream of GNAS, PRKAR1A, PDE4D, and PDE3A. Here we will review the impressive progress that has been made over the past 30 years on the pathophysiology of these diseases and will describe the recently proposed novel nomenclature and classification. Read More

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http://dx.doi.org/10.1159/000491045DOI Listing
November 2018

Conventional Treatment of Hypoparathyroidism.

Front Horm Res 2019 19;51:160-164. Epub 2018 Nov 19.

The treatment of hypoparathyroidism depends on the severity of hypocalcemia, how rapidly the hypocalcemia developed, and the symptomatology. Chronic hypoparathyroidism is usually treated with oral supplementations, including calcium, calcitriol, or other active vitamin D analogs, and at times, thiazide diuretics. Although the standard therapy can adequately control patients with this disease, sometimes very high doses are required to maintain serum calcium levels in the normal range, with poor compliance and risk of long-term complications. Read More

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http://dx.doi.org/10.1159/000491046DOI Listing
November 2018

Normocalcemic Hyperparathyroidism.

Authors:
Sabrina Corbetta

Front Horm Res 2019 19;51:23-39. Epub 2018 Nov 19.

Parathyroid hormone (PTH) disorders are characterized by a wide spectrum of clinical and biochemical presentations. The increasing use of serum PTH assay in the set of the diagnostic workout in patients with osteoporosis has identified patients with features of surgically confirmed primary hyperparathyroidism (PHPT) associated with persistent normal serum calcium levels, which has been recognized as a distinct entity from hypercalcemic PHPT (HPHPT) by the last international consensus. Normocalcemic PHPT (NPHPT) affects about 6-8% of PHPT patients. Read More

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http://dx.doi.org/10.1159/000491036DOI Listing
November 2018

Nonparathyroid Hypercalcemia.

Authors:
David Goltzman

Front Horm Res 2019 19;51:77-90. Epub 2018 Nov 19.

Primary hyperparathyroidism is among the most common causes of hypercalcemia. However, ingestion of medication, including hydrochlorathiazide, lithium, and foscarnet, excessive vitamin A ingestion, endocrinopathies such as hyperthyroidism, adrenal insufficiency, and acromegaly, abnormal nutrient intake such as parenteral nutrition in preterm infants and milk-alkali syndrome, and prolonged immobilization have all been associated with hypercalcemia. The most common cause of nonparathyroid hypercalcemia is neoplasia. Read More

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http://dx.doi.org/10.1159/000491040DOI Listing
November 2018

Familial Hypocalciuric Hypercalcemia and Neonatal Severe Hyperparathyroidism.

Front Horm Res 2019 19;51:52-62. Epub 2018 Nov 19.

Familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT) are genetically determined variants of primary hyperparathyroidism. FHH usually has a benign course, and patients do not require treatment, whereas NSHPT is a severe disorder often requiring early parathyroidectomy for young patients to survive. Recent discoveries in the genetic basis and new findings in therapeutic approaches have led to a great interest in these rare diseases. Read More

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http://dx.doi.org/10.1159/000491038DOI Listing
November 2018

Familial and Hereditary Forms of Primary Hyperparathyroidism.

Front Horm Res 2019 19;51:40-51. Epub 2018 Nov 19.

Individuals with a familial predisposition to the development of parathyroid tumors constitute a small minority of all patients with primary hyperparathyroidism (PHPT). These familial syndromes exhibit Mendelian inheritance patterns and the main causative genes in most families have been identified. They include multiple endocrine neoplasia (MEN; types 1, 2A, and 4), hyperparathyroidism-jaw tumor (HPT-JT) syndrome, familial isolated hyperparathyroidism, familial hypocalciuric hypercalcemia (FHH), and neonatal severe PHPT. Read More

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https://www.karger.com/Article/FullText/491037
Publisher Site
http://dx.doi.org/10.1159/000491037DOI Listing
November 2018
2 Reads

Resistance Exercise Improves Mitochondrial Quality Control in a Rat Model of Sporadic Inclusion Body Myositis.

Gerontology 2019 Jan 14:1-13. Epub 2019 Jan 14.

Department of Exercise Biochemistry, Korea National Sport University, Seoul, Republic of

Background: Mitochondrial dysfunction is implicated in the pathogenesis of multiple muscular diseases, including sporadic inclusion body myositis (s-IBM), the most common aging-related muscle disease. However, the factors causing mitochondrial dysfunction in s-IBM are unknown.

Objective: We hypothesized that resistance exercise (RE) may alleviate muscle impairment by improving mitochondrial function via reducing amyloid-beta (Aβ) accumulation. Read More

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http://dx.doi.org/10.1159/000494723DOI Listing
January 2019

Classification of Hypoparathyroid Disorders.

Front Horm Res 2019 19;51:127-138. Epub 2018 Nov 19.

The term hypoparathyroidism encompasses a huge group of disorders all characterized by an abnormal mineral homeostasis determined by inadequate secretion of parathyroid hormone. Postsurgical hypoparathyroidism is a complication of neck surgery (thyroidectomy, parathyroidectomy, lymph node, and cancer neck dissection), closely related to the extent of the surgical procedure and the experience of the surgeon. If lasting more than 6 months it is defined as chronic hypoparathyroidism, requiring life-long replacement therapy with active vitamin D metabolites. Read More

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http://dx.doi.org/10.1159/000491043DOI Listing
November 2018

Secondary and Tertiary Hyperparathyroidism.

Front Horm Res 2019 19;51:91-108. Epub 2018 Nov 19.

Secondary hyperparathyroidism (SHP) is a frequent complication of kidney diseases. At variance with all the other forms of SHP, which are compensatory conditions, renal SHP has many pathogenetic peculiarities, which have been only in part defined. Furthermore, in the long course of chronic kidney diseases (CKD), SHP sometimes transforms into a hypercalcemic condition resembling the autonomous form of hyperparathyroidism (tertiary hyperparathyroidism; THP). Read More

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http://dx.doi.org/10.1159/000491041DOI Listing
November 2018

Primary Hyperparathyroidism.

Authors:
Laura Masi

Front Horm Res 2019 19;51:1-12. Epub 2018 Nov 19.

The 4 parathyroid glands derive from the third and fourth pharyngeal pouches and descend caudally to the anterior neck. Through the secretion of parathyroid hormone (PTH), the parathyroid glands are primarily responsible for maintaining extracellular calcium and phosphorus concentrations. Hypercalcemia may be distinguished in parathyroid-hypercalcemia and nonparathyroid hypercalcemia. Read More

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http://dx.doi.org/10.1159/000491034DOI Listing
November 2018

Evaluation of controlled-release triamcinolone acetonide-loaded mPEG-PLGA nanoparticles in treating experimental autoimmune uveitis.

Nanotechnology 2019 Jan 14. Epub 2019 Jan 14.

Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Shandong University, Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan, 250002, Jinan, 250002, CHINA.

Uveitis is a recurrent, sight-threatening intraocular inflammatory disease and is treated with glucocorticoids in clinical practice. In the present study, methoxypoly(ethyleneglycol)-poly(dl-lactide-co-glycolic acid) (mPEG-PLGA) nanoparticles in combination with triamcinolone acetonide (TA) were fabricated using a modified double emulsification method. Further, we characterized the TA-loaded nanoparticles, investigated the effects of TA-loaded nanoparticles on experimental autoimmune uveitis rats, including histopathological examination and the alterations of interleukin (IL)-17 and IL-10 at mRNA and protein levels in either aqueous humor or serum. Read More

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http://dx.doi.org/10.1088/1361-6528/aafe36DOI Listing
January 2019

Transcriptome analysis reveals immune-related gene expression changes with age in giant panda () blood.

Aging (Albany NY) 2019 Jan 14. Epub 2019 Jan 14.

Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, College of Life Science, Sichuan University, Chengdu 610064, China.

The giant panda (), an endangered species endemic to western China, has long been threatened with extinction that is exacerbated by highly contagious and fatal diseases. Aging is the most well-defined risk factor for diseases and is associated with a decline in immune function leading to increased susceptibility to infection and reduced response to vaccination. Therefore, this study aimed to determine which genes and pathways show differential expression with age in blood tissues. Read More

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http://dx.doi.org/10.18632/aging.101747DOI Listing
January 2019

Hepatitis B Virus Infection: What Is Current and New.

Authors:
Marion G Peters

Top Antivir Med 2019 Jan;26(4):112-116

University of California San Francisco, San Francisco, CA, USA.

Hepatitis B virus (HBV) infection is a lifelong dynamic disease that can be controlled with treatment but cannot yet be cured. Risk of end-stage liver disease and hepatocellular carcinoma (HCC) increases with ongoing inflammation and HBV viremia. Initial treatments consist of tenofovir or entecavir. Read More

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January 2019

Infectious and Other Complications of Immunobiologic Agents.

Authors:
Peter Chin-Hong

Top Antivir Med 2019 Jan;26(4):100-103

University of California San Francisco, San Francisco, CA, USA.

Individuals with HIV infection are living longer, and are at risk of autoimmune disorders and cancers associated with aging. Many of these conditions are treated with immunobiologic agents that affect immune function and may increase risk of opportunistic infections (OIs) and other immune disorders in individuals with HIV infection. For example, tumor necrosis factor-alpha inhibitors, used to treat such disorders as Crohn's disease, are associated with risk of tuberculosis and histoplasmosis. Read More

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January 2019

MicroRNA-Based Prophylaxis in a Mouse Model of Cirrhosis and Liver Cancer.

Mol Ther Nucleic Acids 2018 Dec 6;14:239-250. Epub 2018 Dec 6.

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy. Electronic address:

Most hepatocellular carcinomas (HCCs) arise in the context of chronic liver disease and/or cirrhosis. Thus, chemoprevention in individuals at risk represents an important but yet unproven approach. In this study, we investigated the ability of microRNA (miRNA)-based molecules to prevent liver cancer development in a cirrhotic model. Read More

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http://dx.doi.org/10.1016/j.omtn.2018.11.018DOI Listing
December 2018

Picomolar detection of retinol binding protein 4 for early management of type II diabetes.

Biosens Bioelectron 2018 Dec 24;128:122-128. Epub 2018 Dec 24.

CNR NANOTEC Institute of Nanotechnology, via Monteroni, 73100 Lecce, Italy; Department of Mathematics and Physics, University of Salento, via Monteroni, 73100 Lecce, Italy. Electronic address:

Type (II) diabetes is one of the major threats to mankind as it causes insulin resistance in human body and Retinol Binding Protein 4 (RBP4) is currently considered as a potential biomarker for early management of this disease. Hence a low-level detection of RBP4 is a very important task and for this purpose, a novel RBP4 biosensor has been developed using homemade plastic chip electrodes (PCEs) as a platform for self-assembled monolayer (SAM) of 4-ATP and further functionalization with glutaraldehyde. Anti RBP4 is used as biorecognition species and electrochemical impedance spectroscopy has been performed to detect different RBP4 concentrations plotted against charge transfer resistance. Read More

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http://dx.doi.org/10.1016/j.bios.2018.12.032DOI Listing
December 2018

Proximity recognition and polymerase-powered DNA walker for one-step and amplified electrochemical protein analysis.

Biosens Bioelectron 2019 Jan 9;128:104-112. Epub 2019 Jan 9.

Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, Ministry of Education; Shandong Key Laboratory of Biochemical Analysis, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, No. 53, Rd., Zhengzhou, Qingdao 266042, China. Electronic address:

The development of simple, flexible, cost-effective and sensitive electrochemical methods for protein analysis is of very importance for its potential application in disease diagnosis and biomedicine research. Herein, a new protein binding-induced proximity recognition and polymerase-powered DNA walker strategy was proposed for one-step and sensitive electrochemical quantification of proteins. Two DNA probes were designed with a hairpin-like one immobilized on the electrode and another one used as a DNA walker strand. Read More

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http://dx.doi.org/10.1016/j.bios.2018.12.053DOI Listing
January 2019

Overdose mortality rates in Croatia and factors associated with self-reported drug overdose among persons who inject drugs in three Croatian cities.

Int J Drug Policy 2019 Jan 11;64:95-102. Epub 2019 Jan 11.

University Hospital for Infectious Diseases "Dr. Fran Mihaljevic", School of Medicine, University of Zagreb, Mirogojska cesta 8, 10000 Zagreb, Croatia. Electronic address:

Background: Drug overdose is the major cause of morbidity and mortality among persons who inject drugs (PWID). We assessed factors associated with the non-fatal drug overdose among PWID in three Croatian cities and national trends of overdose-related mortality (OM), and rates of uptake of opioid agonist drug treatment (OAT).

Methods: We used a respondent-driven sampling method to recruit 830 PWID in Zagreb, Split and Rijeka in 2014/2015. Read More

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http://dx.doi.org/10.1016/j.drugpo.2018.11.017DOI Listing
January 2019

Stressful life events and alcohol consumption in pregnant women: A cross-sectional survey.

Midwifery 2019 Jan 3;71:27-32. Epub 2019 Jan 3.

Department of Neuroscience and Behavior, Section of Child and Adolescent Psychiatry, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil, Av. dos Bandeirantes, 3900, 14049-900 Ribeirao Preto, SP, Brazil. Electronic address:

Background: Psychological stress in pregnancy has been related to different adaptations (physical, emotional and social) of the woman's life during this period. Although maternal stress is a common occurrence in pregnancy, studies indicate that the high levels of stressful life events are a predisposing factor to alcohol consumption in pregnant women. Though postnatal maternal emotional distress has been extensively investigated, little is known about the association between stressful life events and maternal risk behaviors during pregnancy. Read More

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http://dx.doi.org/10.1016/j.midw.2018.12.019DOI Listing
January 2019

Utility of combined inflammatory biomarkers for the identification of cognitive dysfunction in non-diabetic participants of the ELSA-Brasil.

Psychoneuroendocrinology 2019 Jan 9;103:61-66. Epub 2019 Jan 9.

Department of Epidemiology, School of Public Health, University of Sao Paulo, Brazil. Electronic address:

Introduction: Insulin resistance and low-grade inflammation are pathophysiological mechanisms shared by type 2 diabetes and dementia. A cluster of biomarkers that could help diagnosing cognitive dysfunction prior to the installation of insulin resistance is desirable. This ELSA sub-study examined whether a cluster of selected inflammatory biomarkers was associated with worse cognitive scores in non-diabetic participants. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.01.003DOI Listing
January 2019

Computational modeling of early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) to identify personalized therapy using genomics.

Leuk Res 2019 Jan 7;78:3-11. Epub 2019 Jan 7.

Department of Medicine/Division of Hematology Oncology, University of Florida, Gainesville, FL, USA. Electronic address:

Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is an aggressive hematological malignancy for which optimal therapeutic approaches are poorly characterized. Using computational biology modeling (CBM) in conjunction with genomic data from cell lines and individual patients, we generated disease-specific protein network maps that were used to identify unique characteristics associated with the mutational profiles of ETP-ALL compared to non-ETP-ALL (T-ALL) cases and simulated cellular responses to a digital library of FDA-approved and investigational agents. Genomics-based classification of ETP-ALL patients using CBM had a prediction sensitivity and specificity of 93% and 87%, respectively. Read More

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http://dx.doi.org/10.1016/j.leukres.2019.01.003DOI Listing
January 2019

New Aspect of Liver IL-17γδ T Cells.

Mol Immunol 2019 Jan 11;107:41-43. Epub 2019 Jan 11.

The First Affiliated Hospital, Biomedical Translational Research Institute and School of Pharmacy, Jinan University, Guangzhou, 510632, China; The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, 511518, China. Electronic address:

Liver is a critical organ where comprehensive immune regulation or defense occurs. γδ T cells in liver represent indispensable population and are found to be regulating a variety of diseases including autoimmunity, cancer, fibrosis, and infections. IL-17 γδ T cells in liver is a functional subset which has been found to have pro-inflammatory effect or anti-infection ability. Read More

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http://dx.doi.org/10.1016/j.molimm.2018.12.030DOI Listing
January 2019

Quantitative Proteomics Reveals the Dynamic Protein Landscape during Initiation of Human Th17 Cell Polarization.

iScience 2018 Dec 26;11:334-355. Epub 2018 Dec 26.

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Tykistökatu 6, FI-20520 Turku, Finland. Electronic address:

Th17 cells contribute to the pathogenesis of inflammatory and autoimmune diseases and cancer. To reveal the Th17 cell-specific proteomic signature regulating Th17 cell differentiation and function in humans, we used a label-free mass spectrometry-based approach. Furthermore, a comprehensive analysis of the proteome and transcriptome of cells during human Th17 differentiation revealed a high degree of overlap between the datasets. Read More

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http://dx.doi.org/10.1016/j.isci.2018.12.020DOI Listing
December 2018

Design, synthesis and molecular docking studies of novel N-arylsulfonyl-benzimidazoles with anti Trypanosoma cruzi activity.

Eur J Med Chem 2019 Jan 7;165:1-10. Epub 2019 Jan 7.

Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina. Electronic address:

Currently, only two drugs (i.e. benznidazole (BZN) and nifurtimox (NFX)) have been approved for the treatment of Trypanosoma cruzi (Tc) infection, the etiological agent causing Chagas disease. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.01.013DOI Listing
January 2019

Blood kidney injury molecule-1 predicts short and longer term kidney outcomes in patients undergoing diagnostic coronary and/or peripheral angiography-Results from the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) study.

Am Heart J 2018 Dec 7;209:36-46. Epub 2018 Dec 7.

Cardiology Division, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA; Baim Institute for Clinical Research, Boston, MA. Electronic address:

Background: Kidney injury is common in patients with cardiovascular disease.

Objectives: We determined whether blood measurement of kidney injury molecule-1 (KIM-1), would predict kidney outcomes in patients undergoing angiographic procedures for various indications.

Methods: One thousand two hundred eight patients undergoing coronary and/or peripheral angiography were prospectively enrolled; blood was collected for KIM-1 measurement. Read More

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http://dx.doi.org/10.1016/j.ahj.2018.12.001DOI Listing
December 2018

Pollution in living and working environments, climate variability, and their impact on non-communicable disease burden.

Sci Total Environ 2019 Jan 8;660:593-594. Epub 2019 Jan 8.

University of Ioannina, Department of Physics, Laboratory of Meteorology, Ioannina, Greece.

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.055DOI Listing
January 2019

Monitoring the health of green turtles in northern Queensland post catastrophic events.

Sci Total Environ 2019 Jan 7;660:586-592. Epub 2019 Jan 7.

WWF-Australia, Brisbane, Queensland 4000, Australia.

Between 2014 and 2017, the Rivers to Reef to Turtles (RRT) project examined the health of green turtles at two coastal sites impacted by urban and agricultural human activities (Cleveland and Upstart Bays) and one proposed pristine site (Howick Group of Reefs) in northern Queensland, Australia, through blood biochemistry and haematology, plasma protein electrophoresis, and clinical assessments including body condition and barnacle counts. Furthermore, cases of mortality were subjected to comprehensive postmortem examination. In an attempt to advance diagnostics, associations between specific contaminants and health of turtles in this region were tested. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.065DOI Listing
January 2019

Melamine and cyanuric acid exposure and kidney injury in US children.

Environ Res 2018 Nov 2;171:18-23. Epub 2018 Nov 2.

Department of Pediatrics, New York University School of Medicine, New York, NY, USA; NYU Wagner School of Public Service, New York, NY, USA; Department of Nutrition, Food, and Public Health, NYU Steinhardt School of Culture, Education and Human Development, New York, NY, USA; NYU Global Institute of Public Health, New York University, New York, NY, USA.

Background: Melamine and cyanuric acid, which are currently used in a variety of common consumer products and present in foods, have been implicated in the development of urolithiasis and acute kidney injury in Chinese children. To determine whether US children have measurable concentrations of these chemicals in their bodies and whether they are at greater risk of acute kidney injury, we measured melamine and cyanuric acid exposure in a cohort of US children and determined their relationship with markers of kidney injury.

Methods: We measured urinary melamine and cyanuric acid in a convenience sample of 109 children (4 months - 8 years) from Seattle, WA and New York City, NY using liquid chromatography with tandem mass spectrometry. Read More

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http://dx.doi.org/10.1016/j.envres.2018.10.038DOI Listing
November 2018

How graphene affects the misfolding of human prion protein: A combined experimental and molecular dynamics simulation study.

Environ Res 2018 Dec 28;171:1-10. Epub 2018 Dec 28.

State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau, China.

As the broad application of graphene in the biomedical field, it is urgent and important to evaluate how the graphene affects the structure and function of the proteins in our body, especially the amyloid-related proteins. Prion protein, as a typical amyloid protein, it misfolding and aggregation will lead to serious prion diseases. To explore if graphene promotes or inhibits the formation of amyloid, here, we combined the experimental and molecular dynamics (MD) simulation methods to study the influence of graphene on the globular domain of prion protein (PrP). Read More

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http://dx.doi.org/10.1016/j.envres.2018.12.057DOI Listing
December 2018

Effect of vermicompost application on root growth and ginsenoside content of Panax ginseng.

J Environ Manage 2019 Jan 11;234:458-463. Epub 2019 Jan 11.

National Institute of Agricultural Sciences, RDA, Wanju, 55365, Republic of Korea.

Vermicomposts are valuable by-products of organic wastes and can be used to improve soil environments in ginseng production. We compared the effects of food waste vermicompost (FWV), cow manure vermicompost (CMV) and paper sludge vermicompost (PSV) on several ginseng root production variables. Interactions between soil chemical properties, root growth, ginsenoside content and plant mineral content were also investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03014797183152
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http://dx.doi.org/10.1016/j.jenvman.2018.12.101DOI Listing
January 2019
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