6,830,713 results match your criteria Diseases of Tetrapyrrole Metabolism - Refsum Disease and the Hepatic Porphyrias

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Impact of extent of disease on 1-year healthcare costs in patients who undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: retrospective observational cohort study.

BJS Open 2020 Jul 11. Epub 2020 Jul 11.

Departments of Surgery, Division of Surgical Oncology, Groningen, the Netherlands.

Background: The goal of this retrospective observational study was to determine the impact of the extent of peritoneal disease on 1-year healthcare costs in patients with colorectal peritoneal metastases (PM) who undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC). The extent of peritoneal disease, expressed by the Peritoneal Cancer Index (PCI), directly affects the complexity of CRS + HIPEC and ultimately survival outcomes. The impact of the PCI on treatment-related healthcare costs remains unknown. Read More

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http://dx.doi.org/10.1002/bjs5.50320DOI Listing

Muscle and serum myostatin expression in type 1 diabetes.

Physiol Rep 2020 Jul;8(13):e14500

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.

Type 1 diabetes (T1D) has been reported to negatively affect the health of skeletal muscle, though the underlying mechanisms are unknown. Myostatin, a myokine whose increased expression is associated with muscle-wasting diseases, has not been reported in humans with T1D but has been demonstrated to be elevated in preclinical diabetes models. Thus, the purpose of this study was to determine if there is an elevated expression of myostatin in the serum and skeletal muscle of persons with T1D compared to controls. Read More

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http://dx.doi.org/10.14814/phy2.14500DOI Listing

Review of Indoor Aerosol Generation, Transport and Control in the Context of COVID-19.

Int Forum Allergy Rhinol 2020 Jul 11. Epub 2020 Jul 11.

Department of Civil, Architectural, and Environmental Engineering, College of Engineering, Drexel University, Philadelphia, PA, USA.

The coronavirus disease 2019 (COVID-19) pandemic has heightened awareness of aerosol generation by human expiratory events and their potential role in viral respiratory disease transmission. Concerns over high Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) viral burden of mucosal surfaces has raised questions about the aerosol generating potential and dangers of many otorhinolaryngologic procedures. However, the risks of aerosol generation and associated viral transmission by droplet or airborne routes for many otorhinolaryngology procedures are largely unknown. Read More

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http://dx.doi.org/10.1002/alr.22661DOI Listing

Curcumin attenuates autoimmunity and renal injury in an experimental model of systemic lupus erythematosus.

Physiol Rep 2020 Jul;8(13):e14501

Department of Physiology & Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.

Systemic lupus erythematosus (SLE) is an autoimmune disorder with prevalent hypertension and renal disease. To avoid side effects of immunosuppressive drugs, alternative therapies are needed. Curcumin has been used in Eastern medicine for its anti-inflammatory and antioxidant properties. Read More

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http://dx.doi.org/10.14814/phy2.14501DOI Listing

Ageing-associated increase in SGLT2 disrupts mitochondrial/sarcoplasmic reticulum Ca homeostasis and promotes cardiac dysfunction.

J Cell Mol Med 2020 Jul 11. Epub 2020 Jul 11.

Departments of Biophysics, Ankara University Faculty of Medicine, Ankara, Turkey.

The prevalence of death from cardiovascular disease is significantly higher in elderly populations; the underlying factors that contribute to the age-associated decline in cardiac performance are poorly understood. Herein, we identify the involvement of sodium/glucose co-transporter gene (SGLT2) in disrupted cellular Ca -homeostasis, and mitochondrial dysfunction in age-associated cardiac dysfunction. In contrast to younger rats (6-month of age), older rats (24-month of age) exhibited severe cardiac ultrastructural defects, including deformed, fragmented mitochondria with high electron densities. Read More

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http://dx.doi.org/10.1111/jcmm.15483DOI Listing

The role of mab-3 in spermatogenesis and ontogenesis of pinewood nematode, Bursaphelenchus xylophilus.

Pest Manag Sci 2020 Jul 11. Epub 2020 Jul 11.

State Key Laboratory of Subtropical Silviculture, College of Forestry and Biotechnology, Zhejiang Agricultural & Forestry University, Hangzhou, 311300, China.

Background: Bursaphelenchus xylophilus is one of the most destructive invasive species, causing extensive economic losses worldwide. The sex ratio of female to male of B. xylophilus plays an important role in the nematode infestation. Read More

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http://dx.doi.org/10.1002/ps.6001DOI Listing

Protective effect of Lactobacillus salivarius Li01 on thioacetamide-induced acute liver injury and hyperammonaemia.

Microb Biotechnol 2020 Jul 11. Epub 2020 Jul 11.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China.

The gut microbiota plays pivotal roles in liver disease onset and progression. The protective effects of Lactobacillus salivarius Li01 on liver diseases have been reported. In this study, we aimed to detect the protective effect of L. Read More

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http://dx.doi.org/10.1111/1751-7915.13629DOI Listing

Indirect skin sign of COVID-19 days: striae rubrae.

J Cosmet Dermatol 2020 Jul 11. Epub 2020 Jul 11.

Department of Dermatology, Karabuk University, Faculty of Medicine, Karabuk, Turkey.

During COVID-19 pandemic, an increase was observed in stress-related dermatological diseases and COVID-19 related rash, while a significant decrease was observed in cosmetological outpatient applications. However, one month after the COVID-19 outbreak began, we observed a rapid increase especially individuals under 20 years of age diagnosed with stria rubrae in dermatology outpatient clinics. The number of patients diagnosed with striae rubrae was four times higher than last month (0. Read More

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http://dx.doi.org/10.1111/jocd.13607DOI Listing

Persistently positive severe acute respiratory syndrome coronavirus 2 (SARS-COV2) nasopharyngeal PCR in a kidney transplant recipient.

Authors:
Kiran Gajurel

Transpl Infect Dis 2020 Jul 11:e13408. Epub 2020 Jul 11.

Division of Infectious Diseases, Carolinas Medical Center, Atrium Health, Charlotte, NC, USA.

Severe acute respiratory syndrome coronavirus 2 (SARS-COV2 ) infection is usually diagnosed by a positive PCR test in respiratory samples. While the respiratory PCR may remain positive for 2-3 weeks in the general population there have been occasional reports of persistent and recurrent positive SARS-COV2 PCR beyond 4 weeks despite clinical resolution . Read More

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http://dx.doi.org/10.1111/tid.13408DOI Listing

Effect of influenza A virus sow vaccination on infection in pigs at weaning: A prospective longitudinal study.

Transbound Emerg Dis 2020 Jul 11. Epub 2020 Jul 11.

Veterinary Population Medicine Department, University of Minnesota, St. Paul, MN, USA.

Although vaccination is the main measure to control influenza A virus (IAV) in swine, there is limited information on the efficacy of sow vaccination on reducing IAV infections in pigs at weaning. We assessed the effect of sow vaccination on IAV infection in pigs at weaning in a cohort of 52 breeding herds studied prospectively. Herds were voluntarily enrolled according to their IAV history, sow vaccination protocol and monitored during six months (prospective longitudinal study). Read More

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http://dx.doi.org/10.1111/tbed.13688DOI Listing

Significance of tumor microenvironment in acquiring resistance to vascular endothelial growth factor-tyrosine kinase inhibitor and recent advance of systemic treatment of clear cell renal cell carcinoma.

Pathol Int 2020 Jul 11. Epub 2020 Jul 11.

Department of Urology, Keio University School of Medicine, Tokyo, Japan.

The development of systemic therapies, including vascular endothelial growth factor-tyrosine kinase inhibitors (VEGF-TKI) and mammalian target of rapamycin (mTOR) inhibitors, represents a major breakthrough in the treatment of patients with renal cell carcinoma (RCC). However, inherent resistance is observed in some patients and acquired resistance commonly develops in many patients within several months of the initiation of systemic therapies. Since these treatments rarely cure patients, their aim is to suppress tumor progression and prolong survival. Read More

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http://dx.doi.org/10.1111/pin.12984DOI Listing

Hypertension burden and challenges across the hypertension treatment cascade among adults enrolled in HIV care in northern Tanzania.

J Clin Hypertens (Greenwich) 2020 Jul 11. Epub 2020 Jul 11.

Duke Global Health Institute, Duke University, Durham, NC, USA.

Failure to address hypertension among people living with HIV (PLWH) may undermine the significant progress made toward reducing mortality among this high-risk population in sub-Saharan Africa (SSA). Here, the authors report hypertension prevalence, diagnosis, and treatment among patients enrolled in HIV care in Tanzania. Patients attending an HIV clinic were consecutively screened for hypertension. Read More

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http://dx.doi.org/10.1111/jch.13929DOI Listing

SNPs in SNCA, MCCC1, DLG2, GBF1 and MBNL2 are associated with Parkinson's disease in southern Chinese population.

J Cell Mol Med 2020 Jul 11. Epub 2020 Jul 11.

Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated with the Shanghai Jiaotong University School of Medicine, Shanghai, China.

Numerous single nucleotide polymorphisms (SNPs), which have been identified as susceptibility factors for Parkinson's disease (PD) as per genome-wide association studies, have not been fully characterized for PD patients in China. This study aimed to replicate the relationship between 12 novel SNPs of 12 genes and PD risk in southern Chinese population. Twelve SNPs of 12 genes were detected in 231 PD patients and 249 controls, using the SNaPshot technique. Read More

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http://dx.doi.org/10.1111/jcmm.15508DOI Listing

The impact of antibiotic allergy testing in transplant patients.

Transpl Infect Dis 2020 Jul 11:e13411. Epub 2020 Jul 11.

Department of Infectious Diseases and Centre for Antibiotic Allergy and Research, Austin Health,, VIC, Australia.

Patient reported antibiotic allergies, so-called antibiotic allergy labels (AAL) are highly prevalent amongst hospitalized patients globally . The highest prevalence of AALs has been found to be in immunocompromised patients, in particular transplant patients, with a large U.S. Read More

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http://dx.doi.org/10.1111/tid.13411DOI Listing

Priming of microglia with IFN-γ impairs adult hippocampal neurogenesis and leads to depression-like behaviors and cognitive defects.

Glia 2020 Jul 11. Epub 2020 Jul 11.

School of Life Science and Technology, Center for Informational Biology, University of Electronic Science and Technology of China, Chengdu, China.

Neuroinflammation driven by interferon-gamma (IFN-γ) and microglial activation has been linked to neurological disease. However, the effects of IFN-γ-activated microglia on hippocampal neurogenesis and behavior are unclear. In the present study, IFN-γ was administered to mice via intracerebroventricular injection. Read More

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http://dx.doi.org/10.1002/glia.23878DOI Listing

Interventional low-dose azithromycin attenuates cigarette smoke-induced emphysema and lung inflammation in mice.

Physiol Rep 2020 Jul;8(13):e14419

Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.

Cigarette smoke (CS)-induced emphysema is an important contributor to chronic obstructive pulmonary disease (COPD). We have shown the efficacy of azithromycin in reducing airway inflammation in COPD and in reducing exacerbations in severe asthma; however, the effects of long-term azithromycin on emphysema development have not been shown. We employed live animal imaging to monitor emphysema-like development and the effects of interventional azithromycin treatment in CS-exposed mice. Read More

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http://dx.doi.org/10.14814/phy2.14419DOI Listing

Revascularization for multivessel disease: Getting closer, but….

Authors:
Samuel M Butman

Catheter Cardiovasc Interv 2020 Jul;96(1):52

Verde Valley Medical Center, Cottonwood, Arizona, USA.

In a registry, it is all about any differences. PCI and CABG for multivessel disease are comparable with regard to risk of death/MI/stroke, but PCI has a significantly higher risk of return to Cath Lab for PCI or even CABG in follow-up. Read More

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http://dx.doi.org/10.1002/ccd.29087DOI Listing

Women with chronic kidney disease undergoing transcatheter aortic valve replacement: Caveat emptor.

Catheter Cardiovasc Interv 2020 Jul;96(1):208-209

Division of Cardiovascular Medicine, Department of Medicine, State University of New York at Stony Brook, Stony Brook, New York, USA.

Over 60% of women presenting for transcatheter aortic valve replacement (TAVR) have coexisting chronic kidney disease (CKD). In women undergoing TAVR, CKD was associated with significantly higher rates of adverse events, including a twofold higher rate of risk-adjusted mortality at 1 year. This study is an important step forward in our understanding of risk stratification in women with CKD undergoing TAVR and suggests that measures to optimize outcomes warrant further investigation in this high-risk group of patients. Read More

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http://dx.doi.org/10.1002/ccd.29080DOI Listing

Peripheral vascular disease in women: Are we analyzing the costs correctly?

Catheter Cardiovasc Interv 2020 Jul;96(1):143-144

Lankenau Medical Center, Main Line Health System, Wynnewood, Pennsylvania, USA.

Women treated with a peripheral vascular intervention, on average, have more comorbidities and cost more per hospital admission than women treated with a percutaneous coronary intervention. The impact of critical limb ischemia on these results is likely significant, but not available in these data. Physicians need to be more aware of the differences in the risks and manifestations of cardiovascular disease in women. Read More

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http://dx.doi.org/10.1002/ccd.29086DOI Listing

Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X -BAX Interaction.

Mol Oncol 2020 Jul 11. Epub 2020 Jul 11.

Departments of Pharmacology & Toxicology, School of Medicine, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.

Tumor cells undergo senescence in response to both conventional and targeted cancer therapy. The induction of senescence in response to cancer therapy can contribute to unfavorable outcomes, potentially including cancer relapse. This work demonstrates that tumor cells induced into senescence by doxorubicin, etoposide, or radiation can give rise to viable tumors in vivo. Read More

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http://dx.doi.org/10.1002/1878-0261.12761DOI Listing

Monitoring skin metastases during immuno- and targeted therapy using total-body 3D photography.

J Eur Acad Dermatol Venereol 2020 Jul 11. Epub 2020 Jul 11.

Department of Dermatology, University Hospital Erlangen, CCC-EMN, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Eruptive skin metastases in melanoma are an uncommon manifestation of rapidly progressive, systemic disease . Type and kinetics of these lesions have not been analyzed before, because of the rarity of the event and technical restrictions of total-body photography. We present the first sequential total-body 3D photography-based analysis by a VECTRA 360WB imaging system of a melanoma patient suffering from disseminated, spreading skin metastases under treatment with immune checkpoint antibodies and subsequent BRAF/MEK inhibition. Read More

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http://dx.doi.org/10.1111/jdv.16806DOI Listing

Sotrastaurin, a PKC inhibitor, attenuates RANKL-induced bone resorption and attenuates osteochondral pathologies associated with the development of OA.

J Cell Mol Med 2020 Jul 11. Epub 2020 Jul 11.

Department of Orthopedics, The Ninth Affiliated Hospital of Guangxi Medical University, Beihai, China.

Osteoarthritis (OA) is a common degenerative disease that affects the musculoskeletal structure of the whole joint, which is characterized by progressive destruction of both articular cartilage and subchondral bone. Treatment of the bone pathologies, particularly osteoclast-mediated subchondral bone loss in the early stages of OA, could prevent subsequent cartilage degeneration and progression of OA. In the present study, the PKC inhibitor, Sotrastaurin, was found to inhibit RANKL-induced osteoclast formation in vitro in a dose- and time-dependent manner. Read More

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http://dx.doi.org/10.1111/jcmm.15404DOI Listing

Disseminated Cryptococcosis with Cutaneous Manifestation.

Transpl Infect Dis 2020 Jul 11:e13412. Epub 2020 Jul 11.

Division of Infectious Diseases, Carolinas Medical Center, Atrium Health, Charlotte, NC, USA.

Cutaneous cryptococcosis is uncommon. It is usually a result of disseminated infection and can present with a wide of variety of skin lesions. We report a case of disseminated cryptococcosis in a kidney transplant recipient who presented with nodular lesions in the forehead following a bout of acute cellular rejection. Read More

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http://dx.doi.org/10.1111/tid.13412DOI Listing

NAFLD is related to Postprandial Triglyceride-enrichment of HDL Particles in Association with Endothelial and HDL Dysfunction.

Liver Int 2020 Jul 11. Epub 2020 Jul 11.

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

NAFLD is closely related with the metabolic syndrome (MetS) and increased risk of cardiovascular disease. Liver fat associates with postprandial hypertriglyceridemia, potentially contributing to triglyceride-enrichment of high-density-lipoproteins (HDL-TG), and subsequent HDL-dysfunction. We assessed liver fat by MR-spectroscopy, and its association with HDL physiochemical properties, and endothelial function, measured as flow-mediated dilation (FMD), before and following 3 consecutive meals, in 36 men with type 2 diabetes (T2DM), with the MetS, and controls. Read More

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http://dx.doi.org/10.1111/liv.14597DOI Listing

Management and outcomes of heart failure patients with CKD: experience from an inter-disciplinary clinic.

ESC Heart Fail 2020 Jul 11. Epub 2020 Jul 11.

Renal and Transplantation Unit, St George's University Hospital NHS Foundation Trust, London, UK.

Aims: CKD-HF patients suffer excess hospitalization and mortality, often under-treated with life-prolonging medications due to fear of worsening renal function and hyperkalaemia. Yet, role of inter-disciplinary working in improving therapy is unknown, which this study aims to investigate.

Methods And Results: Clinical, biochemical data, and medications at first and last clinic visit were obtained from patient records for 124 patients seen in kidney failure-heart failure clinic (23 March 2017 to 11 April 2019). Read More

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http://dx.doi.org/10.1002/ehf2.12796DOI Listing

Nitric oxide and oxidative stress pathways do not contribute to sex differences in renal injury and function in Dahl SS/Jr rats.

Physiol Rep 2020 Jul;8(13):e14440

Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.

The burden of hypertension in the United States is increasing and yields significant morbidity and mortality, and sex differences in hypertension are widely recognized. Reduced nitric oxide (NO) bioavailability and increased oxidative stress are known to contribute to the pathogenesis of hypertensive renal injury, and but their contributions to sex differences in injury progression of are undefined. Our purpose was to test the hypothesis that male hypertensive rats have accelerated renal injury compared to females and to determine the contributions of the nitric oxide pathway and oxidative stress in these differences. Read More

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http://dx.doi.org/10.14814/phy2.14440DOI Listing

Topical RT1640 treatment effectively reverses gray hair and stem cell loss in a mouse model of radiation-induced canities.

Pigment Cell Melanoma Res 2020 Jul 11. Epub 2020 Jul 11.

Department of Biology, University of Alabama at Birmingham, Birmingham, AL, USA.

Gray hair is a visible sign of tissue degeneration during aging. Graying is attributed to dysfunction of melanocyte stem cells (McSCs) that results in depletion of their melanin-producing progeny. This non-lethal phenotype makes the hair follicle and its pigment system an attractive model for investigating mechanisms that contribute to tissue aging as well as therapeutic strategies to combat this process. Read More

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http://dx.doi.org/10.1111/pcmr.12913DOI Listing

Increased Inflammasome Activity in Subcutaneous Adipose Tissue of Patients with Metabolic Syndrome.

Diabetes Metab Res Rev 2020 Jul 11. Epub 2020 Jul 11.

VA Medical Center, Mather, California.

Aims: The metabolic syndrome (MetS) is an inflammatory disorder associated with an increased risk for diabetes and atherosclerotic cardiovascular disease (ASCVD). Studies in patients and animal models of obesity and diabetes have shown increased NOD-like receptor family pyrin domain containing 3 (NLPR3) inflammasome activity. However, there is scanty data on the activity of the NLRP3 inflammasome in patients with nascent MetS. Read More

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http://dx.doi.org/10.1002/dmrr.3383DOI Listing

Huntingtin gene CAG repeat size affects autism risk: Family-based and case-control association study.

Am J Med Genet B Neuropsychiatr Genet 2020 Jul 11. Epub 2020 Jul 11.

Interdepartmental Program "Autism 0-90", "Gaetano Martino" University Hospital, University of Messina, Messina, Italy.

The Huntingtin (HTT) gene contains a CAG repeat in exon 1, whose expansion beyond 39 repeats consistently leads to Huntington's disease (HD), whereas normal-to-intermediate alleles seemingly modulate brain structure, function and behavior. The role of the CAG repeat in Autism Spectrum Disorder (ASD) was investigated applying both family-based and case-control association designs, with the SCA3 repeat as a negative control. Significant overtransmission of "long" CAG alleles (≥17 repeats) to autistic children and of "short" alleles (≤16 repeats) to their unaffected siblings (all p < 10 ) was observed in 612 ASD families (548 simplex and 64 multiplex). Read More

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http://dx.doi.org/10.1002/ajmg.b.32806DOI Listing

De novo mutation and skewed X-inactivation in girl with BCAP31-related syndrome.

Hum Mutat 2020 Jul 11. Epub 2020 Jul 11.

Departments of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.

Full genome analysis of a young girl with deafness, dystonia, central hypomyelination, refractory seizure, and fluctuating liver function impairment revealed a heterozygous, de novo variant in the BCAP31 gene on chromosome Xq28 (NM_001256447.2:c.92G>A), mutations of which caused the X-linked recessive severe neurologic disorder DDCH (Deafness, Dystonia, and Cerebral Hypomyelination). Read More

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http://dx.doi.org/10.1002/humu.24080DOI Listing

Homozygous mutations in C1QBP as cause of Progressive External Ophthalmoplegia (PEO) and mitochondrial myopathy with multiple mtDNA deletions.

Hum Mutat 2020 Jul 11. Epub 2020 Jul 11.

Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.

Biallelic mutations in the C1QBP gene have been associated with mitochondrial cardiomyopathy and combined Respiratory-Chain deficiencies, with variable onset (including intrauterine or neonatal forms), phenotypes and severity. We studied two unrelated adult patients from consanguineous families, presenting with Progressive External Ophthalmoplegia (PEO), mitochondrial myopathy and without any heart involvement. Muscle biopsies from both patients showed typical mitochondrial alterations and the presence of multiple mitochondrial DNA deletions, whereas biochemical defects of the Respiratory-Chain were present only in one subject. Read More

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http://dx.doi.org/10.1002/humu.24081DOI Listing

Letter to the Editor: D-dimer and presumptive diagnosis of COVID-19.

Acad Emerg Med 2020 Jul 11. Epub 2020 Jul 11.

Royal College Emergency Residency Program and Emergency Department, Faculty of Medicine, McGill University, Montréal, Canada.

We read with interest, "D-dimer triage for COVID-19" by Chenghong et al. This observational cohort study from Wuhan, China concludes that a D-dimer done at admission could be an effective and easily available diagnostic surrogate marker for coronavirus disease-19 (COVID-19). We are concerned that several limitations in the study's methodology affect the authors' conclusions. Read More

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http://dx.doi.org/10.1111/acem.14085DOI Listing

High-protein diet more effectively reduces hepatic fat than low-protein diet despite lower autophagy and FGF21 levels.

Liver Int 2020 Jul 11. Epub 2020 Jul 11.

Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, 14558, Germany.

Background And Aims: Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent and nutrition intervention remains the most important therapeutic approach for NAFLD. Our aim was to investigate whether low- (LP) or high-protein (HP) diets are more effective in reducing liver fat and reversing NAFLD and which mechanisms are involved.

Methods: 19 participants with morbid obesity undergoing bariatric surgery were randomized into two hypocaloric (1500-1600 kcal/day) diet groups, a low protein (10E% protein) and a high protein (30E% protein), for three weeks prior to surgery. Read More

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http://dx.doi.org/10.1111/liv.14596DOI Listing

STIs and the COVID-19 pandemic: the lockdown does not stop sexual infections.

J Eur Acad Dermatol Venereol 2020 Jul 11. Epub 2020 Jul 11.

Division of Dermatology, STI Clinic, Santa Chiara Hospital, Trento, Italy.

In December 2019 a novel coronavirus (SARS-CoV-2) emerged in Wuhan, China, responsible for an aggressive interstitial pneumonia. Italy was the first western country to be hit by the CoronaVIrus Disease 2019 (COVID-19) and on 9 March our Prime Minister announced a nationwide lockdown, strictly forbidding any contacts outside cohabitants, except for urgent or medical reasons. In compliance with the ministerial decree, all scheduled visits were suspended, maintaining hospital access only for emergencies. Read More

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http://dx.doi.org/10.1111/jdv.16808DOI Listing

Shift work and incidence of dementia: A Danish Nurse Cohort study.

Alzheimers Dement 2020 Jul 11. Epub 2020 Jul 11.

Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Introduction: A few studies suggest that working night and rotating shifts increase the risk of dementia. We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses.

Methods: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018. Read More

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http://dx.doi.org/10.1002/alz.12126DOI Listing

Decreased RPM reduces von Willebrand factor degradation with the EVAHEART LVAS: implications for device-specific LVAD management.

J Card Surg 2020 Jul;35(7):1477-1483

Evaheart Inc, Houston, Texas.

Background: Continuous-flow left ventricular assist devices (LVADs) produces supraphysiologic shear stress that causes von Willebrand factor (VWF) degradation and a bleeding diathesis. Reduction of revolutions per minute (RPM) with axial-flow LVADs does not decrease shear stress enough to reduce VWF degradation and bleeding. However, it is unknown if RPM reduction with centrifugal flow LVADs may minimize VWF degradation. Read More

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http://dx.doi.org/10.1111/jocs.14620DOI Listing

Anomalous origin of left vertebral artery from descending thoracic aorta: A rare variant.

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiovascular Radiology and Endovascular Interventions, All India Institute of Medical Sciences, New Delhi, India.

We present a case of a 4-year-old child operated previously for cyanotic congenital heart disease where the follow-up computed tomography (CT) angiography revealed anomalous origin of the left vertebral artery from the descending thoracic aorta. This case also highlights the potential implications of this variant and the value of CT angiography in diagnosing this anomaly. Read More

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http://dx.doi.org/10.1111/jocs.14786DOI Listing

Tricuspid annuloplasty: Too many, too few? Virtue may be in the middle!

Authors:
Manuel J Antunes

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Clinic of Cardiothoracic Surgery, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Background: Significant secondary tricuspid regurgitation, often accompanied by right ventricular dilation and dysfunction, occurs in a significant proportion of patients submitted to surgery for severe mitral valve disease. It appears a vicious circle that is not interrupted by the treatment of the left heart valve alone, hence it requires concomitant intervention on the tricuspid valve.

Aims: In this commentary I will discuss a paper published in this issue of the Journal by Calafiore et al from Riyadh - Saudi Arabia, reporting a retrospective study that evaluated the influence of preoperative right ventricular and tricuspid valve (TV) remodeling on the fate of tricuspid annuloplasty (TA) and RV in 423 patients undergoing TA for functional TR operated on from May 2009 to December 2015 at their institution. Read More

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http://dx.doi.org/10.1111/jocs.14843DOI Listing

Density-induced social stress alters oxytocin and vasopressin activities in the brain of a small rodent species.

Integr Zool 2020 Jul 11. Epub 2020 Jul 11.

State Key Laboratory of Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

It is known that social stress could alter oxytocin (OT) and arginine-vasopressin (AVP) expression in specific regions of brains which regulate the aggressive behavior of small rodents, but the effects of density-induced social stress are still unknown. Brandt's voles (Lasiopodomys brandtii) is a small herbivores in the grassland of China, but the underlying neurological mechanism of population regulation is still unknown. We tested the effects of housing density of Brandt's voles on OT/AVP system with physical contact (allowing aggression) and without physical contact (not allowing aggression) under laboratory conditionunder laboratory conditions. Read More

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http://dx.doi.org/10.1111/1749-4877.12467DOI Listing

The value of preoperative high-resolution MRI with microscopy coil for facial nonmelanoma skin cancers.

Skin Res Technol 2020 Jul 11. Epub 2020 Jul 11.

Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, P.R.China.

Background: The extent and depth of facial nonmelanoma skin cancers and the involvement of adjacent structures are critical features for surgical planning, but they are difficult to assess clinically. High-resolution MRI (HR-MRI) with microscopy coil may facilitate detailed evaluation of skin lesions. The authors performed this prospective study to determine the value of high-resolution microscopy coil MRI in the preoperative evaluation of nonmelanoma skin cancer. Read More

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http://dx.doi.org/10.1111/srt.12909DOI Listing

Metabolic implication of tigecycline as an efficacious second-line treatment for sorafenib-resistant hepatocellular carcinoma.

FASEB J 2020 Jul 11. Epub 2020 Jul 11.

Institute of Pharmacy, Center for Public Health, Paracelsus Medical University, Salzburg, Austria.

Sorafenib represents the current standard of care for patients with advanced-stage hepatocellular carcinoma (HCC). However, acquired drug resistance occurs frequently during therapy and is accompanied by rapid tumor regrowth after sorafenib therapy termination. To identify the mechanism of this therapy-limiting growth resumption, we established robust sorafenib resistance HCC cell models that exhibited mitochondrial dysfunction and chemotherapeutic crossresistance. Read More

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http://dx.doi.org/10.1096/fj.202001128RDOI Listing

Identification and genetic characterization of Contracaecum sp. (Nematoda Anisakidae) from China.

Integr Zool 2020 Jul 11. Epub 2020 Jul 11.

National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Contracaecum species are economically important fish-borne larval nematodes with zoonotic significance. In June 2019, more than one hundred piscivorous birds were died in its habitats close to the Wild Duck Lake, located in Yanqing, northwest of Beijing, China. Post-mortem examination of Black Night Herons (Nycticorax) revealed the presence of numerous anisakid nematodes in the proventriculus. Read More

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http://dx.doi.org/10.1111/1749-4877.12465DOI Listing

Low protein intake during reproduction compromises the recovery of lactation-induced bone loss in female mouse dams without affecting skeletal muscles.

FASEB J 2020 Jul 11. Epub 2020 Jul 11.

Institute of Life Course and Medical Sciences, The MRC - Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing (CIMA), University of Liverpool, Liverpool, UK.

Lactation-induced bone loss occurs due to high calcium requirements for fetal growth but skeletal recovery is normally achieved promptly postweaning. Dietary protein is vital for fetus and mother but the effects of protein undernutrition on the maternal skeleton and skeletal muscles are largely unknown. We used mouse dams fed with normal (N, 20%) or low (L, 8%) protein diet during gestation and lactation and maintained on the same diets (NN, LL) or switched from low to normal (LN) during a 28 d skeletal restoration period post lactation. Read More

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http://dx.doi.org/10.1096/fj.202001131RDOI Listing

Nuclear β-catenin immunoexpression in scars.

J Cutan Pathol 2020 Jul 11. Epub 2020 Jul 11.

Department of Diagnostic Pathology, Shizuoka Cancer Center Hospital, Nagaizumi, Japan.

Background: Histopathologically, scars can mimic superficial fibromatoses. Superficial fibromatoses are known to show nuclear β-catenin immunoexpression, although the tumor types do not harbor CTNNB1 or APC alterations. The present study aimed to evaluate nuclear β-catenin immunoexpression in scars compared to that in superficial fibromatoses. Read More

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http://dx.doi.org/10.1111/cup.13806DOI Listing

Clinical and Laboratory Interpretation of Mitochondrial mRNA Variants.

Hum Mutat 2020 Jul 11. Epub 2020 Jul 11.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TEXAS, USA.

Interpretation of mitochondrial protein-encoding (mt-mRNA) variants has been challenging due to mitochondrial characteristics that have not been addressed by ACMG guidelines. We developed criteria for the interpretation of mt-mRNA variants via literature review of reported variants, tested and refined these criteria by using our new cases, followed by interpreting 421 novel variants in our clinical database using these verified criteria. Thirty-two out of 56 previously reported pathogenic (P) variants had convincing evidence for pathogenicity. Read More

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http://dx.doi.org/10.1002/humu.24082DOI Listing

Long-term risk of heart failure and mortality following mitral valve surgery in patients with and without right ventricular pacemaker.

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Medicine, Section of Cardiovascular Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts.

Objectives: Patients undergoing mitral valve surgery are at risk of developing postoperative conduction blocks and have a high incidence of heart failure (HF). Mitral valve surgery often results in reduced left ventricular systolic ejection fraction following surgery and the imposition of dyssynchrony with right ventricular (RV) pacing may further compromise stroke volume. Our aim was to investigate the risks of HF and mortality in patients with vs without RV pacemaker placement (PPM) after mitral valve surgery. Read More

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http://dx.doi.org/10.1111/jocs.14847DOI Listing

MicroRNA-142 regulates osteoblast differentiation and apoptosis of mouse pre-osteoblast cells by targeting bone morphogenetic protein 2.

FEBS Open Bio 2020 Jul 11. Epub 2020 Jul 11.

Department of Anesthesiology, Weifang People's Hospital, Weifang, Shandong Province, 261041, P. R. China.

Osteoporosis is a common disease that can seriously impair the physical and mental health of the elderly. However, current treatment is unsatisfactory, due to the lack of effective therapeutic targets. Abnormal expression and involvement of microRNA-142 (miR-142) have been identified in many diseases, including bone-related diseases. Read More

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http://dx.doi.org/10.1002/2211-5463.12929DOI Listing

MR Elastography-Based Liver Fibrosis Correlates with Liver Events in Nonalcoholic Fatty Liver Patients: A Multi-Center Study.

Liver Int 2020 Jul 11. Epub 2020 Jul 11.

Fatty Liver Program, Division of Digestive and Liver Diseases, Comprehensive Transplant Program, Cedars-Sinai Medical Center, Los Angeles, California, United States.

Background & Aims: Liver fibrosis assessed by liver biopsy is predictive of clinical liver events in patients with nonalcoholic fatty liver disease (NAFLD). Magnetic resonance elastography (MRE) correlates with liver biopsy in assessing liver fibrosis. However, data assessing the relationship between MRE and clinical liver events are lacking. Read More

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http://dx.doi.org/10.1111/liv.14593DOI Listing

Acquired von Willebrand syndrome secondary to mitral and aortic regurgitation.

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiovascular Surgery, National Hospital Organization Tokyo Medical Center, Meguro, Tokyo, Japan.

Background: The association of aortic valve stenosis with gastrointestinal bleeding was first described by Edward Heyde in 1958. Since then, there have been numerous case reports of Heyde syndrome in the medical literature worldwide.

Aims: Recently, the definition of Heyde syndrome has been updated to include the combination of aortic valve stenosis, intestinal angiodysplasia, and acquired von Willebrand factor syndrome (AVWS). Read More

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http://dx.doi.org/10.1111/jocs.14796DOI Listing

'Well, if I don't show up and go through with the fertility treatment, I won't have a baby'; Patient involvement in clinical practice: Option or condition?

J Eval Clin Pract 2020 Jul 11. Epub 2020 Jul 11.

Department of Public Health, Nursing, Aarhus University, Aarhus, Denmark.

Rationale, Aims, And Objectives: Worldwide, the concept of patient involvement has a growing impact on health care. Involvement in care represents a benefit to many patients, but while being involved is inevitable for the patient, we assume that getting involved is not in all cases obtainable. On this background, we aimed to investigate patients' perceptions and experiences concerning their treatment and care in a clinical fertility treatment setting, and discuss how these may influence their possibilities for involvement in care. Read More

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http://dx.doi.org/10.1111/jep.13435DOI Listing
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