6,269,501 results match your criteria Diseases of Tetrapyrrole Metabolism: Refsum Disease and the Hepatic Porphyrias

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Treatment consensus for management of polymyositis and dermatomyositis among rheumatologists, neurologists and dermatologists.

J Dermatol 2018 Dec 18. Epub 2018 Dec 18.

Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.

Although rheumatologists, neurologists and dermatologists see patients with polymyositis (PM) and dermatomyositis (DM), their management appears to vary depending on the physician's specialty. The aim of the present study was to establish the treatment consensus among specialists of the three fields to standardize the patient care. We formed a research team supported by a grant from the Ministry of Health, Labor and Welfare, Japan. Read More

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http://dx.doi.org/10.1111/1346-8138.14604DOI Listing
December 2018

Twenty-five years of research about adipogenic adenoviruses: A systematic review.

Obes Rev 2018 Dec 18. Epub 2018 Dec 18.

Department of Nutritional Sciences, Texas Tech University, Lubbock, TX, USA.

Infectious etiology is implicated in chronic diseases such as gastric ulcer or atherosclerosis. However, "infection" is a recent term in the field of obesity. Since the first report in 1982 of obesity due to infection, several microbes have been linked to obesity. Read More

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http://dx.doi.org/10.1111/obr.12808DOI Listing
December 2018

Optimal surgical treatment in patients with T1b gallbladder cancer: An international multicenter study.

J Hepatobiliary Pancreat Sci 2018 Dec;25(12):533-543

Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.

Background: There is no consensus on the optimal treatment of T1b gallbladder cancer (GBC) due to the lack of evidence and the difficulty of anatomy and pathological standardization.

Methods: A total of 272 patients with T1b GBC who underwent surgical resection at 14 centers with specialized hepatobiliary-pancreatic surgeons and pathologists in Korea, Japan, Chile, and the United States were studied. Clinical outcomes including disease-specific survival (DSS) rates according to the types of surgery were analyzed. Read More

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http://dx.doi.org/10.1002/jhbp.593DOI Listing
December 2018

Intra-articular Corticosteroids for Knee Pain-What Have We Learned from the Equine Athlete and Current Best Practice.

J Knee Surg 2018 Dec 18. Epub 2018 Dec 18.

Department of Orthopaedic Surgery, Division of Sports Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

The use of intra-articular corticosteroids for traumatic arthritis and osteoarthritis (OA) is common in the horse. The beneficial and deleterious effects of the principal corticosteroids used betamethasone esters (Celestone [Soluspan], methylprednisolone acetate [Depo Medrol], and triamcinolone acetonide [TA] [Vetalog or Kenalog]) have been defined for the horse. While TA has both disease-modifying as well as symptom-modifying effects, methyl prednisolone acetate has deleterious effects on the articular cartilage. Read More

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http://dx.doi.org/10.1055/s-0038-1676449DOI Listing
December 2018

An Update on Addison's Disease.

Exp Clin Endocrinol Diabetes 2018 Dec 18. Epub 2018 Dec 18.

Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany.

Addison's disease - the traditional term for primary adrenal insufficiency (PAI) - is defined as the clinical manifestation of chronic glucocorticoid- and/or mineralocorticoid deficiency due to failure of the adrenal cortex which may result in an adrenal crisis with potentially life-threatening consequences. Even though efficient and safe pharmaceutical preparations for the substitution of endogenous gluco- and mineralocorticoids are established in therapy, the mortality in patients with PAI is still increased and the health-related quality of life (HRQoL) is often reduced.PAI is a rare disease but recent data report an increasing prevalence. Read More

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http://dx.doi.org/10.1055/a-0804-2715DOI Listing
December 2018

[It can not be healthy not to be ill].

Dtsch Med Wochenschr 2018 Dec 18;143(25):1826-1831. Epub 2018 Dec 18.

This article is written in remembrance of Karl Valentin's 70th anniversary of his death. He was a comedian and song writer suffering from vegetative dystonia and depression lifelong. This hypochondriac developed extreme self observation and had anxiety to get ill permanently. Read More

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http://dx.doi.org/10.1055/a-0649-0274DOI Listing
December 2018

["Humor does not make disease" - Paracelsus' scientific revolution].

Authors:
Christian Hick

Dtsch Med Wochenschr 2018 Dec 18;143(25):1820-1825. Epub 2018 Dec 18.

Paracelsus was an adventurer in more than one way. We retrace the little that is known about his life and then focus on his adventures in the history of ideas, namely the scientific revolution he brought about for humoral pathology. Following the landmark study of Pagel (1982) we identify two of his conceptions of disease: diseases as fruits and diseases as minerals, discovered by a new science, a "scientia separationis". Read More

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http://dx.doi.org/10.1055/a-0601-0473DOI Listing
December 2018

Correction: Congenital Transcobalamin II Deficiency: A Rare Entity with a Broad Differential.

Klin Padiatr 2017 Nov 18;229(6):e1. Epub 2018 Dec 18.

Pediatric Hematology Oncology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1055/a-0820-5131DOI Listing
November 2017

[Immunometabolism and systemic lupus erythematosus].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1120-1124

Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha 410008, China.

Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease, characterized by production of pathogenic autoantibodies and wide involvement of multiple systems. Damageofimmune tolerance and imbalance of immune homeostasis lead to the production of autoantibodies and the injuries of multiple organs and systems. In recent years, plenty of studies have identified that immunometabolism affects survival status of certain cells, also cell activation, differentiation and effector functions. Read More

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December 2018

[A case of gout secondary to primary myelofibrosis].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1117-1119

Department of Rheumatology and Immunology,Peking University First Hospital, Beijing 100034, China.

A 52-year-old man was referred to our department with a 2-year history of polyarthritis. He was diagnosed as gout due to acute arthritis of bilateral feet dorsum 2 years ago,but he didn't receive any standard treatment. 1 year ago,there were more and more joints evolved during the gout attack, and many subcutaneous nodules occurred. Read More

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December 2018

[Systemic lupus erythematosus with acquired hemophilia A: a case report].

Authors:
F Yang Y S Zhou Y Jia

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1108-1111

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.

Acquired hemophilia A (AHA) is anunusual disease resulting from autoantibodies (inhibitors) against coagulation factor VIII (FVIII) and clinically manifests as bleeding, which sometimes can cause potentially limb-threatening or life-threatening situations. AHA is associated with cancers, auto-immune disorders, infections, dermatologic conditions and certain medications, among which it is commonly secondary to multiple rheumatologic conditions, such as rheumatoid arthritis, systemic lupus erythematosus (SLE), pollymyositis, autoimmune hemolytic anemia and undifferentiated connective tissue disease. In autoimmune diseases, it may be the result of autoantibody producing against FVIII, and some cases of AHA may act as the first manifestation of SLE. Read More

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December 2018

[Posterior reversible encephalopathy syndrome in systemic lupus erythematosus: a case report].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1102-1107

Department of Rheumatology and Immunology, Peking University First Hospital, Beijing 100034, China.

This case report concerns a 22-year-old woman who had been diagnosed with systemic lupus erythematosus (SLE). She had intermittent fever, butterfly erythema, photosensitivity, oral ulcers, and multiple arthralgia in the past seven years, but she did not adhere to regular treatments. The edema of the lower extremities and face aggravated in the recent two weeks, so she was admitted to our Department of Rheumatology and Clinical Immunology. Read More

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December 2018

[Retrospective analysis of early dental implant failure].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1088-1091

First Clinical Division, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100034, China.

Objective: To analyze the risk factors of early dental implant failure,treatment and prognosis.

Methods: Cases of dental implants in the first clinical division from January 2000 to December 2016 were selected according to inclusion criteria. The differences of gender,age,smoking,location of implants, healing abutments and bone graft were compared between early failed implants and success implants. Read More

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December 2018

[Staining effect of bovine incisors in vitro by tea solutions].

Authors:
M M Zhu Y L Li J Pan

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1083-1087

Department of General, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To determine the optimum staining condition of tea solutions on bovine incisors in vitro, by comparing the color stability of tooth surface of different concentrations of tea solutions and methods on bovine incisors in vitro.

Methods: Twenty bovine incisors with color surface A1 were chosen, then randomly divided into 4 groups (n=10). Group 1: soaked with 2% tea solution continuously for 6 days; group 2: soaked with 2% tea solution for 6 days, but changed fresh tea solution everyday; group 3: soaked with 1% tea solution continuously for 6 days; group 4: soaked with 1% tea solution for 6 days but fresh tea solution changed every day. Read More

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December 2018

[Effects of intranasal dexmedetomidine for children undergoing dental rehabilitation under general anesthesia: a double-blinded randomized controlled trial].

Authors:
L Gao Y Liu X D Yang

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1078-1082

Department of Anesthesiology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To observe the preoperative sedation, the status of separation from parents, compliance with the mask, hemodynamic parameters and postoperative agitation of intranasal dexmedetomidine (DEX) premedication on children undergoing dental rehabilitation under general anesthesia.

Methods: In the study, 60 children of American Society of Anesthesiology classification (ASA I-II), aged 2-9 years, were randomly assigned to one of two equal groups. Thirty minutes before operation, control group received intranasal placebo (0. Read More

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December 2018

[Clinical analysis of candidemia in immunocompetent patients].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1063-1069

Department of Nosocomial Infection,Peking University Third Hospital, Beijing 100191, China.

Objective: To investigate the etiological and clinical characteristics of immunocompetent patients with candidemia.

Methods: The clinical and microbiological data of patients diagnosed as candidemia admitted in Peking University Third Hospital from January 2010 to June 2016 were retrospectively analyzed. Underlying diseases, Candida spp. Read More

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December 2018

[Single-center study of laparoscopic radical nephrectomy with Mayo 0-2 level inferior vena cava thrombectomy].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1053-1056

Department of Urology, Peking University Third Hospital, Beijing 100191, China.

Objective: To investigate the safety and feasibility of laparoscopic treatment for renal carcinoma with Mayo 0-2 level venous thrombosis.

Methods: From January 2015 to February 2018, 58 renal carcinoma cases with venous thrombus underwent laparoscopic radical nephrectomy with inferior vena cava thrombectomy in Department of Urology, Peking University Third Hospital, of which, 51 cases were male, and 7 female, aged 29-82 years. According to the Mayo grade classification, 20 cases were level 0, 20 cases were level 1, and 18 cases were level 2, with left side being 22 cases, and right side 36 cases. Read More

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December 2018

[Application of artificial ligament in treatment of lower abdominal wall reconstruction after pubic tumor resection].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1049-1052

Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing 100044, China.

Objective: For patients who had hemipelvectomies involving the resection of a portion or the whole of the pubis, bony reconstruction was not recommended commonly. However, the soft tissue reconstruction of the lower abdominal wall may benefit these patients. The object of the study was to determine the clinical effect of lower abdominal wall reconstruction with LARS ligament after pubic tumor resection interms of patient-reported and objective outcome. Read More

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December 2018

[A multi-center cross-sectional survey of medicine application in patients with osteoarthritis in China].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1044-1048

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.

Objective: To investigate the clinical characteristics, the medicine application and to evaluate the disease activity in patients with osteoarthritis (OA) in China.

Methods: This was a cross-sectional study. Totally 1 066 cases of OA from 40 hospitals in China from April to October 2017 were retrospectively enrolled. Read More

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December 2018

[A cross-sectional study of the clinical features and physician visit patterns at onset of immunoglobulin G4 related disease].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1039-1043

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.

Objective: To comprehend clinical features and patient's physician visit patterns at onset of immunoglobulin G4 related disease (IgG4RD).

Methods: In the study, 100 patients with IgG4RD who received treatments in the Department of Rheumatology and Immunology of Peking University People's Hospital from Apr. 1st, 2017 to Apr. Read More

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December 2018

[Case series and clinical analysis of 14 cases of catastrophic antiphospholipid syndrome].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1033-1038

Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.

Objective: Catastrophic antiphospholipid syndrome (CAPS), also known as Asherson's syndrome, is a special subtype of antiphospholipid syndrome (APS) characterized by multiple intravascular thrombosis involving multiple organs systems or tissues simultaneously or continuously, high titer antiphospholipid antibodies and high mortality rate. This article's aims was to analyze the clinical manifestation, laboratory examination and treatment therapy of CAPS for the purpose of improving the understanding, diagnosis and treatment of the disease in clinical practice.

Methods: Retrospective analysis and descriptive statistics were applied to the clinical manifestations and laboratory findings of 14 CAPS cases from APS Shanghai Database (APS-SH) with catastrophic antiphospholipid. Read More

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December 2018

[Increased serum soluble-endoglin level and its clinical significance in antiphospholipid syndrome].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1027-1032

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.

Objective: To detect the serum levels of soluble endothelial glycoprotein endoglin (s-Eng) in patients with antiphospholipid syndrome (APS) and to evaluate the correlation between s-Eng levels and clinical features and laboratory parameters.

Methods: The levels of serum s-Eng were measured by enzyme linked immunosorbent assay (ELISA) in 139 patients with APS, 44 patients with SLE but no APS, 37 patients with primary Sjögren's syndrome (pSS), 23 patients with Bechet's disease (BD), 22 patients with systemic sclerosis (SSc) and 22 persistent anticardiolipin antibody (aCL) positive individuals without SLE or APS (simply aCL positive group) and 87 health controls (HC) without any auto-immune diseases. These APS patients included 64 primary APS patients and 75 APS patients secondary to SLE. Read More

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December 2018

[Comparison of disease activities and extent measurements for anti-neutrophil cytoplasmic autoantibody-associated vasculitis].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1022-1026

Department of Rheumatology, Fouth Medical Center of PLA General Hospital, Beijing 100048, China.

Objective: To investigate the significance of a set of seven disease activities and extension measurements and their correlations between one and another for anti-neutrophil cytoplasmic autoantibody associated vasculitis (AAV).

Methods: A total of 121 patients from Peking University International Hospital and Fouth Medical Center of PLA General Hospital with confirmed diagnoses of AAV clinically were enrolled in the study, including 15 cases of eosinophilic granulomatous with polyangiitis (EGPA), 59 cases of granulomatous with polyangiitis (GPA) and 47 cases of microscopic polyangiitis (MPA). A hundred and twenty-one AAV patients were divided into death group and survival group according to their survival conditions. Read More

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December 2018

[Efficacy of mesenchymal stem cells on systemic lupus erythematosus:a meta-analysis].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1014-1021

Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.

Objective: Systemic lupus erythematosus (SLE) is an autoimmune disease with multi-organ involvement and several typical autoantibodies. Mesenchymal stem cells (MSC) are multipotent stem cells with low immunogenicity that can differentiate into various kinds of cells, such as bone, cartilage, fat and skin tissue. MSC have immunomodulatory and reparative properties through interactions with immune cells. Read More

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December 2018

[Multidisciplinary classification of magnetic resonance imaging features of neuropsychiatric lupus].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1009-1013

Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China.

Objective: To investigate the clinical correlation between the manifestations of neuropsychiatric lupus (NPSLE) and brain magnetic resonance imaging (MRI).

Methods: Retrospective analysis of 65 neuropsychiatric lupus patients with brain MRI and clinical data from Peking University Third Hospital from January 2006 to October 2016, which was classified by rheumatologist, neurologists, and radiologists based on their brain MRI findings. The correlation between brain MRI findings and clinical manifestations was analyzed. Read More

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December 2018

[Clinical and immunological characteristics of patients with systemic lupus erythematosus in Tibet plateau, China].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):1004-1008

Department of Rheumatology and Immunology, Tibet Autonomous Region People's Hospital, Lhasa 850000, China.

Objective: To describe the clinical, immunological characteristics and organ involvement of patients with systemic lupus erythematosus (SLE) in Tibet plateau, China.

Methods: We retrospectively investigated 70 patients admitted in the Tibet Autonomous Region People's Hospital between May 2014 and April 2016. In the study, 120 hospitalized patients with SLE from the Department of Rheumatology and Immunology of the Peking University People's Hospital were randomly selected as the control (plain) group. Read More

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December 2018

[Study of bone mineral density and serum bone turnover markers in newly diagnosed systemic lupus erythematosus patients].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):998-1003

Department of Rheumatology and Immunology, Peking University People's Hospital,Beijing 100044, China.

Objective: To investigate the changes of bone mineral density (BMD) and serum bone turnover factor in newly diagnosed systemic lupus erythematous (SLE) patients.

Methods: Eighty newly diagnosed SLE patients and 80 age and gender matched healthy controls were enrolled. None of the SLE patients had ever received glucocorticoid, immunosuppressive agents or vitamin D. Read More

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December 2018

[Effect of functional exercises on patients with rheumatoid arthritis: a meta-analysis].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):991-997

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China.

Objective: To evaluate the effect of functional exercises on disease activity, joint function and quality of life of patients with rheumatoid arthritis (RA).

Methods: Randomized controlled trials were searched in Cochrane Library, PubMed, China National Knowledge Infrastructure (CNKI), VIP database and Wanfang database with keywords being "rheumatoid arthritis/RA", "function exercise (training)/joint exercise (training)/physical exercise (training)/resistance movement (exercise)/isotonic and isometric/stretching exercise/muscle exercise", and "trials/clinical trials". Then literature selection, extraction and literature quality evaluation were carried out by two of the authors independently following the including and excluding standards. Read More

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December 2018

[Clinical characteristic of 74 cases of malignant tumor in rheumatoid arthritis].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):986-990

Department of Rheumatology and Immunology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

Objective: To investigate the clinical characteristics of rheumatoid arthritis (RA) patients with malignant tumor.

Methods: Retrospective summary was made of 1 562 in patients of RA from January 2011 to June 2017. In the study, 74 RA patients with malignant tumor were reviewed and analyzed, and the general conditions, tumor types, RA and tumor onset sequence, and the medication situation were analyzed. Read More

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December 2018

[Value of serum matrix metalloproteinase 3 in the assessment of early rheumatoid arthritis].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):981-985

Department of Rheumatology and Immunology, Peking University People's Hospital & Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135) Beijing 100044, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University School of Pharmaceutical Sciences, Beijing 100191, China.

Objective: To investigate the expression level of serum matrix metalloproteinase 3 (MMP3) in early rheumatoid arthritis (ERA) patients with normal C-reaction protein (CRP) or erythrocyte sedimentation rate (ESR), and the significance in disease assessment.

Methods: In the study, 133 cases of early RA patients, 25 osteoarthritis (OA) patients and 60 healthy controls in Peking University People's Hospital from 2011 to 2015 were included. The RA patients were further divided into 4 groups according to levels of CRP and ESR: 88 patients with increased CRP and increased ESR, 15 patients with normal CRP and normal ESR, 17 patients with normal CRP but increased ESR, and 13 patients with increased CRP but normal ESR. Read More

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December 2018

[Clinical significance of detection of soluble interleukin 2 receptor alpha chain in the assessment of rheumatoid arthritis disease activity].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):975-980

Department of Rheumatology and Immunology, Peking University People's Hospital,Beijing 100044, China.

Objective: To evaluate soluble interleukin-2 receptor alpha chain (sIL-2Rα, sCD25) in serum for the determination of rheumatoid arthritis (RA) activity.

Methods: Peripheral blood was collected from 108 patients with RA, 39 patients with osteoarthritis (OA) and 50 healthy control subjects, and synovial fluids were from 40 patients with RA. The sera from the patients with RA, the disease control group (osteoarthritis), the healthy control group, and the synovial fluids of the RA patients were detected by enzyme-linked immunosorbent assay (ELISA). Read More

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December 2018

[Increased receptor activator of nuclear factor kappa B ligand expressed on B10 cells in rheumatoid arthritis].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):968-974

Department of Rheumatology and Immunology,the People's Hospital of China Three Gorges University,Yichang 443000, Hubei, China.

Objective: To detect receptor activator of nuclear factor kappa B ligand (RANKL) expressed on B10 cells in rheumatoid arthritis (RA) and to evaluate the correlation between RANKL-producing B10 cells in RA and clinical features and laboratory parameters, trying to reveal the possible role of B10 cells in the pathogenesis of RA and the potential mechanism of impaired immunosuppressive capacities.

Methods: 25 RA patients and 20 healthy volunteers were enrolled. These RA patients did not received treatment with glucocorticoids, disease-modifying anti-rheumatic drug and biologics during the recent half of a year. Read More

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December 2018

[Diagnosis and treatment of antiphospholipid antibody-related recurrent spontaneous abortion and analysis of therapeutic drugs and pregnancy outcome in 75 patients with antiphospholipid syndrome].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):956-961

Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China.

Recurrent spontaneous abortion is one of the common complications in women of childbearing age during pregnancy. The immune factor accounts for a large proportion of many causes. Antiphospholipid antibody syndrome is the most common type of acquired thrombophilia disease. Read More

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December 2018

Baicalin Ameliorates Collagen-Induced Arthritis Through the Suppression of Janus Kinase 1 (JAK1)/Signal Transducer and Activator of Transcription 3 (STAT3) Signaling in Mice.

Med Sci Monit 2018 Dec 18;24:9213-9222. Epub 2018 Dec 18.

Department of Rheumatology, Qilu Hospital of Shandong University, Ji'nan, Shandong, China (mainland).

BACKGROUND Rheumatoid arthritis is an autoimmune disease that causes chronic joint inflammation and there is no cure. Baicalin, as an ingredient in the roots of Scutellaria baicalensis, is supposed to possess an anti-inflammatory effect. However, the protective effect of baicalin on collagen-induced arthritis requires further investigation. Read More

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http://dx.doi.org/10.12659/MSM.910347DOI Listing
December 2018

Garcinia Multiflora Inhibits FPR1-Mediated Neutrophil Activation and Protects Against Acute Lung Injury.

Cell Physiol Biochem 2018 Dec 12;51(6):2776-2793. Epub 2018 Dec 12.

Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan,

Background/aims: Formyl peptide receptors (FPRs) recognize different endogenous and exogenous molecular stimuli and mediate neutrophil activation. Dysregulation of excessive neutrophil activation and the resulting immune responses can induce acute lung injury (ALI) in the host. Accordingly, one promising approach to the treatment of neutrophil-dominated inflammatory diseases involves therapeutic FPR1 inhibition. Read More

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http://dx.doi.org/10.1159/000495970DOI Listing
December 2018

Long Noncoding RNA HOTTIP Promotes Mouse Hepatic Stellate Cell Activation via Downregulating miR-148a.

Cell Physiol Biochem 2018 Dec 13;51(6):2814-2828. Epub 2018 Dec 13.

Background/aims: HOTTIP is a critical modulator in human diseases including liver cancer, but its role and molecular biological mechanisms in liver fibrosis are still unclear.

Methods: The expression profile of HOTTIP during the progression of liver fibrosis was detected in human liver samples and in CCl4-treated mice using qRT-PCR. The expressing sh-HOTTIP adenoviral vector was used to reduce HOTTIP levels in vivo. Read More

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http://dx.doi.org/10.1159/000496012DOI Listing
December 2018

Shikimic Acid Inhibits Osteoclastogenesis in Vivo and in Vitro by Blocking RANK/TRAF6 Association and Suppressing NF-κB and MAPK Signaling Pathways.

Cell Physiol Biochem 2018 Dec 14;51(6):2858-2871. Epub 2018 Dec 14.

Department of Orthopedics, Shanghai Changhai Hospital, Second Military Medical University, Shanghai,

Background/aims: Bone homeostasis is associated with the balance between bone-resorbing osteoclasts and bone-forming osteoblasts. Unbalanced bone homeostasis as a result of reduced osteogenesis or excessive osteoclastogenesis can lead to disorders such as osteoporosis, Paget's disease, and rheumatoid arthritis. Shikimic acid is a cyclohexanecarboxylic acid, reported to exhibit pharmacological properties including anti-inflammatory and antioxidant activities. Read More

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http://dx.doi.org/10.1159/000496039DOI Listing
December 2018

High Expressions of CUL4A and TP53 in Colorectal Cancer Predict Poor Survival.

Cell Physiol Biochem 2018 Dec 18;51(6):2829-2842. Epub 2018 Dec 18.

Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai,

Background/aims: Cullin 4A (CUL4A) is vital in cell survival, development, growth and cell cycle, it plays an important role in chaperone-mediated ubiquitination and interacts with TP53 in carcinogenesis. However, the clinicopathologic significance of CUL4A expression in colorectal cancer is unknown; in particular, the prognostic value of CUL4A combined with TP53 expression has not been explored.

Methods: We analyzed the expression of CUL4A in both public database (Oncomine) and 180 cases of colorectal cancer and paired normal tissues by real-time polymerase chain reaction and western blotting. Read More

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http://dx.doi.org/10.1159/000496013DOI Listing
December 2018

Loss of Tumor Suppressor Gene Function in Human Cancer: An Overview.

Cell Physiol Biochem 2018 Dec 12;51(6):2647-2693. Epub 2018 Dec 12.

Research Institute of Pharmaceutical Science, Department of Pharmacy, Seoul National University College of Pharmacy, Seoul, Republic of

Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research has been conducted over the last few decades to elucidate the role of TSGs in cancer development. In cancer, loss of TSG function occurs via the deletion or inactivation of two alleles, according to Knudson's two-hit model hypothesis. Read More

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http://dx.doi.org/10.1159/000495956DOI Listing
December 2018

FOXD1 Promotes Cell Growth and Metastasis by Activation of Vimentin in NSCLC.

Cell Physiol Biochem 2018 Dec 12;51(6):2716-2731. Epub 2018 Dec 12.

Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Background/aims: Forkhead box D1 (FOXD1) has a well-established role in early embryonic development and organogenesis and functions as an oncogene in several cancers. However, the clinical significance and biological roles of FOXD1 in non-small cell lung cancer (NSCLC) remain largely unknown.

Methods: A total of 264 primary NSCLC tissue samples were collected. Read More

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http://dx.doi.org/10.1159/000495962DOI Listing
December 2018

Coccomyxa Gloeobotrydiformis Polysaccharide Inhibits Lipopolysaccharide-Induced Inflammation in RAW 264.7 Macrophages.

Cell Physiol Biochem 2018 Dec 11;51(6):2523-2535. Epub 2018 Dec 11.

Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang,

Background/aims: Inflammation plays a vital role in the etiology and pathogenesis of chronic noncommunicable diseases (NCDs), which are the leading health issues throughout the world. Our previous studies verified the satisfactory therapeutic effects of Coccomyxa gloeobotrydiformis (CGD) polysaccharide on several NCDs. In this study, we aimed to investigate the anti-inflammatory effects of CGD polysaccharide, and the corresponding molecular mechanisms, on lipopolysaccharide (LPS)-induced inflammation in RAW264. Read More

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http://dx.doi.org/10.1159/000495922DOI Listing
December 2018

Expression of PRDX6 Correlates with Migration and Invasiveness of Colorectal Cancer Cells.

Cell Physiol Biochem 2018 Dec 11;51(6):2616-2630. Epub 2018 Dec 11.

Institute of Nursing and Department of Nursing, Chang Gung Institute of Technology Chiayi Campus, Chiayi, Taiwan.

Background/aims: Colorectal cancer (CRC) is the third most common type of cancer and the second leading cause of cancer-related deaths worldwide. PRDXs are antioxidant enzymes that play an important role in cell differentiation, proliferation and apoptosis and have diverse functions in malignancy development. However, the mechanism of aberrant overexpression of PRDX6 in CRC remains unclear. Read More

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http://dx.doi.org/10.1159/000495934DOI Listing
December 2018

The Prognostic Significance of NEK2 in Hepatocellular Carcinoma: Evidence from a Meta-Analysis and Retrospective Cohort Study.

Cell Physiol Biochem 2018 Dec 12;51(6):2746-2759. Epub 2018 Dec 12.

Department of Hepatic Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou,

Background/aims: Numerous studies have shown that NIMA-related kinase 2 (NEK2) expression in hepatocellular carcinoma (HCC) tissue is associated with survival and clinicopathological features; however, the evidence remains inconclusive. Thus, we aimed to further explore the prognostic and clinicopathological significance of NEK2 expression in HCC using a two-part study consisting of a retrospective cohort study and a meta-analysis.

Methods: In the cohort study, NEK2 expression in 206 HCC samples and adjacent normal liver tissues was detected by immunohistochemistry (IHC). Read More

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http://dx.doi.org/10.1159/000495966DOI Listing
December 2018

miR-486-3p Influences the Neurotoxicity of a-Synuclein by Targeting the SIRT2 Gene and the Polymorphisms at Target Sites Contributing to Parkinson's Disease.

Cell Physiol Biochem 2018 Dec 12;51(6):2732-2745. Epub 2018 Dec 12.

Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Guangdong,

Background/aims: Increasing evidence suggests the important role of sirtuin 2 (SIRT2) in the pathology of Parkinson's disease (PD). However, the association between potential functional polymorphisms in the SIRT2 gene and PD still needs to be identified. Exploring the molecular mechanism underlying this potential association could also provide novel insights into the pathogenesis of this disorder. Read More

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http://dx.doi.org/10.1159/000495963DOI Listing
December 2018
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Targeting PPARα for the Treatment and Understanding of Cardiovascular Diseases.

Cell Physiol Biochem 2018 Dec 12;51(6):2760-2775. Epub 2018 Dec 12.

Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.

Three members of the peroxisome proliferator-activated receptor (PPAR) family, PPARα, PPARγ, and PPARβ/δ, have been investigated widely over the past few decades. Although the roles of these PPARs and their agonists/antagonists were defined in clinical and basic studies, the conflicting results from these studies indicate that more analysis is needed to understand the roles of PPARs. PPARα is a ligand-activated transcription factor that contributes to the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis. Read More

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http://dx.doi.org/10.1159/000495969DOI Listing
December 2018

UV-light mediated green synthesis of silver and gold nanoparticles using Cornelian cherry fruit extract and their comparative effects in experimental inflammation.

J Photochem Photobiol B 2018 Dec 11;191:26-37. Epub 2018 Dec 11.

Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, 11 Arany Janos Street, 400028 Cluj-Napoca, Romania. Electronic address:

The purpose of our study is to investigate the comparative effects of materials based on silver and gold nanoparticles functionalized with polyphenols from Cornus Mas extract (AgNPs-CM and AuNPs-CM) in vivo on experimental inflammation. The nanoparticles were obtained at room temperature under UV irradiation and were characterized by different methods: ultraviolet-visible spectroscopy, transmission electron microscopy, X ray diffraction, Fourier transform infrared spectroscopy and dynamic light scattering. The modulatory effects of AgNPs-CM and AuNPs-CM on inflammation were quantified by oxidative stress parameters, pro and anti-inflammatory cytokines levels and apoptosis assessment at 2 h, 24 and 48 h after induction of inflammation with carrageenan in the paw tissue of Wistar rats. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2018.12.006DOI Listing
December 2018

Long-term survival in patients with advanced non-small-cell lung cancer treated with atezolizumab versus docetaxel: Results from the randomised phase III OAK study.

Eur J Cancer 2018 Dec 15;107:124-132. Epub 2018 Dec 15.

Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Background: Atezolizumab (anti-programmed death-ligand 1 [PD-L1]) received approval from the US Food and Drug Administration and European Medicines Agency for previously treated advanced non-small-cell lung cancer based on OAK-a randomised, phase III trial that showed significantly improved survival with atezolizumab versus docetaxel regardless of PD-L1 expression. With longer follow-up, we summarised the characteristics of long-term survivors (LTSs).

Methods: In OAK (NCT02008227), patients were randomised 1:1 to receive atezolizumab or docetaxel until loss of clinical benefit or disease progression, respectively. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.11.020DOI Listing
December 2018

Arsenic exposure and young adult's mortality risk: A 13-year follow-up study in Matlab, Bangladesh.

Environ Int 2018 Dec 15;123:358-367. Epub 2018 Dec 15.

ICDDRB, 68 Shahid Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh.

Background: Widespread arsenic contamination in underground water is a well-documented public health concern that threatens millions of lives worldwide. We investigated the risk of young-adult mortality due to high chronic exposure to arsenic through years of drinking arsenic contaminated water.

Methods: A prospective cohort study of 58,406 individuals was enrolled who were 4-18 years at baseline. Read More

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http://dx.doi.org/10.1016/j.envint.2018.12.006DOI Listing
December 2018
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