210,595 results match your criteria Disability and Rehabilitation [Journal]


Development and validation of a brief electronic screening test for cognitive impairment in multiple sclerosis (SCI-MS Test).

Mult Scler Relat Disord 2018 Dec 3;28:50-56. Epub 2018 Dec 3.

Department of Neurology, Clinical Neuroimmunology and Multiple Sclerosis Unit, "Donostia" Universitary Hospital, San Sebastian, Spain.

Objective: Although cognitive impairment (CI) is common in multiple sclerosis (MS), it is difficult to suspect in patients with low disability and there is a lack of brief and effective CI screening tools with a define cut-off point to be used during routine clinic visits. This study aims to validate the Electronic Screening Cognitive Impairment in Multiple Sclerosis (SCI-MS) test for CI among MS patients.

Methods: Cross-sectional, observational study that included adult patients, diagnosed with MS, Expanded Disability Status Scale (EDSS) score ≤6. Read More

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December 2018

Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity.

Mult Scler Relat Disord 2018 Dec 5;28:34-43. Epub 2018 Dec 5.

Neuroimmunological Diseases Section (NDS), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 5N248, 10 Center Drive, MSC1444, Bethesda, MD 20892, United States. Electronic address:

Background: Once multiple sclerosis (MS) reaches the progressive stage, immunomodulatory treatments have limited efficacy. This suggests that processes other than activation of innate immunity may at least partially underlie disability progression during late stages of MS. Pathology identified these alternative processes as aberrant activation of astrocytes and microglia, and subsequent degeneration of oligodendrocytes and neurons. Read More

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December 2018

PF CAT Outcomes in Diabetic Lumbar Spine Surgical Patients.

Spine J 2018 Dec 12. Epub 2018 Dec 12.

University of Utah Department of Orthopaedic Surgery, 590 Wakara Way, Salt Lake City, UT 84108. Electronic address:

Background Context: Diabetes is a highly prevalent comorbid condition among patients undergoing spine surgery. Several studies have used legacy patient-reported outcome measures to implicate diabetes as a predictor of increased disability, pain, and decreased physical function and quality of life following spine surgery. The effect of diabetes on postoperative physical function has not yet been studied using the PROMIS Physical Function Computer Adaptive Test (PF CAT). Read More

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December 2018

Identification of a circulating miRNA signature in extracellular vesicles collected from amyotrophic lateral sclerosis patients.

Brain Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemistry and Biochemistry, Université de Moncton, 18 Antonine-Maillet Avenue, Moncton, New Brunswick, E1A 3E9, Canada. Electronic address:

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder associated with the progressive death of motor neurons. Mean survival for a patient diagnosed with ALS is between 2 to 5 years. Early and efficient diagnosis of the various forms of ALS remains a significant challenge, resulting in a need to identify clinically-relevant biomarkers in readily accessible body fluids. Read More

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December 2018

Depressive symptoms and cerebral microvascular disease in adults with Type 1 diabetes mellitus.

Diabet Med 2018 Dec 15. Epub 2018 Dec 15.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

Aim: To assess the prevalence of and risk factors for depressive symptoms, comparing a sample of middle-aged adults with and without juvenile-onset Type 1 diabetes mellitus, and to determine if depressive symptoms were associated with white matter hyperintensity volume among those with Type 1 diabetes.

Methods: Depressive symptoms and white matter hyperintensities were compared between adults (age range 30-65 years) with juvenile-onset Type 1 diabetes (n=130) and adults without Type 1 diabetes (n=133). The association of Type 1 diabetes with depression was computed before and after adjustment for white matter hyperintensities. Read More

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December 2018

Imaging in neurointerventional stroke treatment: review of the recent trials and what your neurointerventionalist wants to know from emergency radiologists.

Emerg Radiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiology and Biomedical Imaging, University of California San Francisco School of Medicine, 550 16th. Street, San Francisco, CA, 94158, USA.

Stroke is one of the leading causes of death and disability worldwide. Standard treatment for stroke is intravenous (IV) injection of tissue plasminogen activator (t-PA) rapidly after symptom onset. However, there are limitations of IV t-PA treatment, such as a short time window for administration and risk for hemorrhage. Read More

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December 2018

A population-based study of cystic white matter injury on ultrasound in very preterm infants born over two decades in Nova Scotia, Canada.

J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiology, Dalhousie University and the IWK Health Centre, Halifax, NS, Canada.

Objective: To identify the temporal trends, risk factors and outcomes of cystic white matter injury (WMI) detected by ultrasound in a population-based cohort of very preterm infants (VPI) with a minimal risk of selection bias.

Study Design: All live-born VPIs between 22 and < 31 weeks gestational age born in Nova Scotia, Canada from 1993 to 2013.

Results: Cystic WMI was identified in 87 (7%) out of 1184 eligible infants. Read More

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December 2018

Multiple biomarkers covering distinct pathways for predicting outcomes after ischemic stroke.

Neurology 2018 Dec 14. Epub 2018 Dec 14.

From the Department of Epidemiology (C.Z., Z.Z., A.W., Tan Xu, X.B., H.P., J.Y., L.H., Tian Xu, Y.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., J.C., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Preventive Medicine (L.H.), Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China; Department of Medicine (J.C., J.H.), Tulane University School of Medicine, New Orleans, LA; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Nantong; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology; Department of Neurology (J.W.), Yutian County Hospital, Tangshan; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Taian; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Tongliao; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.

Objective: To study the prognostic significance of multiple novel biomarkers in combination after ischemic stroke.

Methods: We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke, and 12 informative biomarkers were measured. The primary outcome was the combination of death and major disability (modified Rankin Scale score ≥3) at 3 months after ischemic stroke, and secondary outcomes included major disability, death, and vascular events. Read More

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December 2018

Behaviour change interventions for the management of Raynaud's phenomenon: a systematic literature review.

BMJ Open 2018 Dec 14;8(12):e024528. Epub 2018 Dec 14.

Centre for Pain Research, University of Bath, Bath, UK.

Objectives: Raynaud's phenomenon (RP) is a significant cause of morbidity. Vasodilator medications cause unwanted adverse effects, with behavioural and lifestyle changes forming the mainstay of self-management; this is difficult to implement successfully. The objectives of this study were to evaluate the efficacy of behaviour change interventions for RP and identify learning points for future treatment development. Read More

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December 2018

Disability and morbidity among older patients in the emergency department: a Danish population-based cohort study.

BMJ Open 2018 Dec 14;8(12):e023803. Epub 2018 Dec 14.

Department of Geriatric Medicine, Odense University Hospital, Odense, Denmark.

Objectives: The objective was to describe the prevalence of geriatric conditions among older medical patients in the emergency department (ED) and the association with admission, mortality, reattendance and loss of independency.

Design: Population-based prospective cohort study.

Setting: ED of a large university hospital. Read More

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December 2018

Ten-year trends in traumatic brain injury: a retrospective cohort study of California emergency department and hospital revisits and readmissions.

BMJ Open 2018 Dec 14;8(12):e022297. Epub 2018 Dec 14.

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.

Objective: To describe visits and visit rates of adults presenting to emergency departments (EDs) with a diagnosis of traumatic brain injury (TBI). TBI is a major cause of death and disability in the USA; yet, current literature is limited because few studies examine longer-term ED revisits and hospital readmission patterns of TBI patients across a broad spectrum of injury severity, which can help inform potential unmet healthcare needs.

Design: We performed a retrospective cohort study. Read More

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December 2018

ICF Generic Set as new standard for the system wide assessment of functioning in China: a multicentre prospective study on metric properties and responsiveness applying item response theory.

BMJ Open 2018 Dec 14;8(12):e021696. Epub 2018 Dec 14.

Swiss Paraplegic Research, Nottwil, Switzerland.

Objectives: To examine metric properties and responsiveness of the International Classification of Functioning, Disability and Health (ICF) Generic Set when used in routine clinical practice to assess functioning.

Design: Prospective multicentre study.

Setting: 50 hospitals from 20 provinces of Mainland China. Read More

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December 2018

Indigenous health worker support for patients with poorly controlled type 2 diabetes: study protocol for a cluster randomised controlled trial of the Mana Tū programme.

BMJ Open 2018 Dec 14;8(12):e019572. Epub 2018 Dec 14.

Te Kupenga Hauora Māori, University of Auckland, Auckland, New Zealand.

Introduction: Type 2 diabetes mellitus (T2DM) and its complications are more common among Māori and Pacific people compared with other ethnic groups in New Zealand. Comprehensive and sustained approaches that address social determinants of health are required to address this condition, including culturally specific interventions. Currently, New Zealand has no comprehensive T2DM management programme for Māori or Pacific people. Read More

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December 2018

Funding and services needed to achieve universal health coverage: applications of global, regional, and national estimates of utilisation of outpatient visits and inpatient admissions from 1990 to 2016, and unit costs from 1995 to 2016.

Lancet Public Health 2018 Dec 11. Epub 2018 Dec 11.

Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA. Electronic address:

Background: To inform plans to achieve universal health coverage (UHC), we estimated utilisation and unit cost of outpatient visits and inpatient admissions, did a decomposition analysis of utilisation, and estimated additional services and funds needed to meet a UHC standard for utilisation.

Methods: We collated 1175 country-years of outpatient data on utilisation from 130 countries and 2068 country-years of inpatient data from 128 countries. We did meta-regression analyses of annual visits and admissions per capita by sex, age, location, and year with DisMod-MR, a Bayesian meta-regression tool. Read More

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December 2018

[Intimacy and disability, experiences in a medical-social care facility].

Soins 2018 Dec;63(831):52-55

Haute école spécialisée de Suisse occidentale (HES-SO), Haute école de travail social et de la santé (EESP), chemin des Abeilles 14, 1010 Lausanne, Suisse. Electronic address:

The issue of the respect of intimacy is raised particularly for people with a motor disability who are dependent on others to perform everyday tasks and are forced to live in a medical-social care facility. Their description of their experiences, difficulties and aspirations offers a better understanding of their needs with a view to providing them with a suitable response. Read More

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December 2018

Attitudes and beliefs about musculoskeletal pain and its association with pain neuroscience knowledge among physiotherapy students in Israel.

Isr J Health Policy Res 2018 Dec 15;7(1):67. Epub 2018 Dec 15.

Department of Physical Therapy, Faculty of Health Sciences Ariel University, 40700, Ariel, Israel.

Background: Physiotherapy has a vital role in helping patients manage and overcome musculoskeletal pain. Healthcare providers' beliefs about pain are associated with the beliefs of their patients. This study evaluated the attitudes, beliefs and level of pain neuroscience knowledge among Israeli Bachelor-level physiotherapy students. Read More

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December 2018

Acknowledgement to reviewers.

Authors:
Editorial Office

S Afr J Commun Disord 2018 Nov 26;65(1):616. Epub 2018 Nov 26.

African Journal of Disability, AOSIS Publishing.

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November 2018

Long noncoding RNA RMRP upregulation aggravates myocardial ischemia-reperfusion injury by sponging miR-206 to target ATG3 expression.

Biomed Pharmacother 2019 Jan 5;109:716-725. Epub 2018 Nov 5.

Department of Experimental and Practical Teaching, Medical Information Engineering of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.

Objective: Coronary heart disease is a common cause of death and disability worldwide and mainly results from myocardial ischemia-reperfusion (I/R) injury. This study aimed to elucidate the roles and possible mechanism of long noncoding RNA Component Of Mitochondrial RNA Processing Endoribonuclease (RMRP) in protecting against ischemic myocardial injury.

Material And Methods: The H9c2 cardiomyocytes were cultured under hypoxia condition to induce myocardial injury. Read More

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January 2019

Downregulation of long noncoding RNA HOTAIRM1 variant 1 contributes to osteoarthritis via regulating miR-125b/BMPR2 axis and activating JNK/MAPK/ERK pathway.

Biomed Pharmacother 2019 Jan 14;109:1569-1577. Epub 2018 Nov 14.

Department of Orthopaedic Surgery, Tianjin Hospital, Hexi, Tianjin, 300211, China.

Objective: Osteoarthritis (OA) is a leading cause of pain and disability worldwide, which is characterized by degenerative and inflammatory processes affecting joints and surrounding tissues. This study aimed to elucidate the role and possible mechanism of long non-coding RNA HOX antisense intergenic RNA myeloid 1 variant 1 (HOTAIRM1-1) in the development of osteoarthritis (OA).

Material And Methods: The expressions of HOTAIRM1-1 and miR-125b in OA cartilages and normal articular cartilages were determined. Read More

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January 2019

Chronic fatigue syndrome (CFS): Suggestions for a nutritional treatment in the therapeutic approach.

Biomed Pharmacother 2019 Jan 5;109:1000-1007. Epub 2018 Nov 5.

Research Department, Innlandet Hospital Trust, Brumunddal, Norway; Inland Norway University of Applied Sciences, Elverum, Norway.

Chronic fatigue syndrome (CFS) is known as a multi-systemic and complex illness, which induces fatigue and long-term disability in educational, occupational, social, or personal activities. The diagnosis of this disease is difficult, due to lacking a proper and suited diagnostic laboratory test, besides to its multifaceted symptoms. Numerous factors, including environmental and immunological issues, and a large spectrum of CFS symptoms, have recently been reported. Read More

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January 2019

Problem behaviours and Major Depressive Disorder in adults with intellectual disability and autism.

Psychiatry Res 2018 Dec 15;270:769-774. Epub 2018 Oct 15.

CREA (Research and Clinical Centre), San Sebastiano Foundation, Florence Italy. Electronic address:

The high prevalence of Problem Behaviours (PB) in persons with intellectual disability (ID) and Autism Spectrum Disorder (ASD) has been associated by some researchers to a proportionate frequency of Major Depressive Disorder (MDD), which have a different presentation in persons with ID and ASD than in the general population, mostly as behavioural changes. Nevertheless, evidence on this behavioural equivalency is still scarce. The present study aims at evaluating the rate of MDD in persons with ID and ASD presenting PB. Read More

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December 2018
1 Read

Work Loss Before and After Diagnosis of Crohn's Disease.

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.

Background: The aim of this study was to examine work loss in patients with Crohn's disease.

Methods: Using nationwide registers, we identified incident patients with Crohn's disease (2007-2010) and population comparator subjects without inflammatory bowel disease, matched by age, sex, calendar year, health care region, and education level. We assessed the number of lost workdays due to sick leave and disability pension from 5 years before to 5 years after first diagnosis of Crohn's disease or end of follow-up (September 30, 2015). Read More

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December 2018
2 Reads

The antecedents of loneliness in older people with an intellectual disability.

Res Dev Disabil 2018 Dec 11;85:116-130. Epub 2018 Dec 11.

School of Nursing and Midwifery, Trinity College Dublin, Dublin, Ireland.

Introduction: The cognitive discrepancy approach to loneliness is often used to describe loneliness in ageing populations, but to date, it has never been used to explore loneliness in older people with an intellectual disability. An analysis is needed utilising a refined list of causes of loneliness in this population.

Method: Using data from a nationally representative dataset of people aged over 40 with an intellectual disability (N = 708), this analysis runs repeated regressions of variables grouped into conceptual blocks, organised from sociodemographic to network quality. Read More

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December 2018

Associations between cognitive impairment and quality of life in euthymic bipolar patients.

Psychiatry Res 2018 Nov 26;271:510-515. Epub 2018 Nov 26.

Department of Psychiatry, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

During the euthymic state in bipolar disorder, cognitive functions often remain affected. Specifically, subjective and objective cognitive impairment might distinctly affect patients' quality of life (QoL); however, this question had not been examined previously in Japanese patients. Therefore, the current study investigated the associations between cognitive complaints, QoL, and objective cognitive functions. Read More

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November 2018
1 Read

Influence of drivers' psychological risk profiles on the effectiveness of traffic calming measures.

Accid Anal Prev 2018 Dec 11;123:243-255. Epub 2018 Dec 11.

Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Via Paradisa 2, 56126, Pisa, Italy.

Road traffic injuries represent a serious public health problem and are one of leading cause of death, injury and disability around the world. Road accidents are often caused by an accumulation of factors; however, drivers appear to be by far the most decisive one. The driver's behaviour is complex and depends on reflex (or involuntary) and voluntary driving actions. Read More

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December 2018

An improved rat model for chronic inflammatory bowel disease.

Pharmacol Rep 2018 Oct 11;71(1):149-155. Epub 2018 Oct 11.

School of Health and Wellbeing, University of Southern Queensland, Toowoomba, QLD, Australia; Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD, Australia. Electronic address:

Background: Inflammatory bowel disease (IBD) is an important cause of chronic disability in humans.

Methods: We characterized a model of chronic IBD in young male Wistar rats by administering dextran sodium sulfate (DSS: 0%, 0.25%, 0. Read More

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October 2018
1 Read

Health risk assessment on N-nitrosodimethylamine in drinking water and food in major cities of China with disability-adjusted life years (DALYs).

Ecotoxicol Environ Saf 2018 Dec 11;170:412-417. Epub 2018 Dec 11.

Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China.

In this study, a health risk assessment of N-nitrosodimethylamine (NDMA) in drinking water and food was conducted using disability-adjusted life years (DALYs) in major cities of China. Considering the numerous non-detected values found in drinking water samples, a zero-inflated model was employed to obtain a more precise NDMA concentration distribution function in drinking water. With exogenous chronic daily intake of 1. Read More

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December 2018

Which patients initiate cognitive processing therapy and prolonged exposure in department of veterans affairs PTSD clinics?

J Anxiety Disord 2018 Nov 20;62:53-60. Epub 2018 Nov 20.

Center for Chronic Disease Outcomes Research, Minneapolis VA Health Care System, One Veterans Drive, Minneapolis, MN 55417, USA; Department of Medicine, University of Minnesota, 420 Delaware St SE, Minneapolis, MN 55455, USA; Department of Psychiatry, University of Minnesota, 2450 Riverside Ave, Minneapolis, MN 55454, USA; Department of Psychology, University of Minnesota, 75 E River Rd, Minneapolis, MN 55455, USA. Electronic address:

The United States Department of Veterans Affairs (VA) provides Cognitive Processing Therapy (CPT) and Prolonged Exposure therapy (PE) for PTSD at all of its facilities, but little is known about systematic differences between patients who do and do not initiate these treatments. VA administrative data were analyzed for 6,251 veterans receiving psychotherapy over one year in posttraumatic stress disorder (PTSD) specialty clinics at nine VA medical centers. CPT and PE were initiated by 2,173 (35%) patients. Read More

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November 2018

Economic impact of dengue in Mexico considering reported cases for 2012 to 2016.

PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006938. Epub 2018 Dec 14.

Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.

Background: Given that dengue disease is growing and may progress to dengue hemorrhagic fever (DHF), data on economic cost and disease burden are important. However, data for Mexico are limited.

Methodology/principal Findings: Burden of dengue fever (DF) and DHF in Mexico was assessed using official databases for epidemiological information, disabilities weights from Shepard et al, the reported number of cases and deaths, and costs. Read More

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December 2018

Asymmetrical interference between number and item size perception provides evidence for a domain specific impairment in dyscalculia.

PLoS One 2018 14;13(12):e0209256. Epub 2018 Dec 14.

Cognitive Neuroimaging Unit, CEA DRF/I2BM, INSERM, Université Paris-Sud, Université Paris-Saclay, NeuroSpin Center, Gif-sur-Yvette, France.

Dyscalculia, a specific learning disability that impacts arithmetical skills, has previously been associated to a deficit in the precision of the system that estimates the approximate number of objects in visual scenes (the so called 'number sense' system). However, because in tasks involving numerosity comparisons dyscalculics' judgements appears disproportionally affected by continuous quantitative dimensions (such as the size of the items), an alternative view linked dyscalculia to a domain-general difficulty in inhibiting task-irrelevant responses. To arbitrate between these views, we evaluated the degree of reciprocal interference between numerical and non-numerical quantitative dimensions in adult dyscalculics and matched controls. Read More

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December 2018

Technique of Fractionated Transcatheter Arterial Embolization for Treating Large Arteriovenous Malformation in Brain Functional Area.

J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing.

Objective: At present, large cranial function area arteriovenous malformation (fAVM) is mainly treated by craniotomy with a high risk of operation and high disability. In recent years, with the continuous improvement of the neural intervention technology, fractionated transcatheter arterial embolization (fTAE) may be used to treat the fAVM instead of surgical treatment. However, its effectiveness for treating fAVM has never been explored. Read More

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December 2018

What Is the Prevalence of Cam Deformity After Prophylactic Pinning of the Contralateral Asymptomatic Hip in Unilateral Slipped Capital Femoral Epiphysis? A 10-year Minimum Followup Study.

Clin Orthop Relat Res 2018 Dec 13. Epub 2018 Dec 13.

T. D. Lerch, F. Schmaranzer, S. D. Steppacher, M. Tannast, K. A. Siebenrock, Department of Orthopaedic Surgery, Inselspital, University of Bern, Bern, Switzerland E. N. Novais, Department of Pediatric Orthopedic surgery, Boston Children's Hospital, Boston, MA, USA K. Ziebarth, Department of Pediatric Surgery, Inselspital, University of Bern, Bern, Switzerland.

Background: Prophylactic pinning of the asymptomatic and normal-appearing contralateral hip in patients with unilateral slipped capital femoral epiphysis (SCFE) remains controversial. Understanding the minimal 10-year clinical, functional, and radiographic outcomes of the contralateral asymptomatic hip in unilateral SCFE may be helpful in the decision regarding whether the benefits associated with potentially preventing a SCFE are outweighed by the risk of additional surgery.

Questions/purposes: Among patients with SCFE treated with prophylactic pinning of the asymptomatic and contralateral hip, we sought (1) to determine the complications and reoperations; (2) to evaluate the development of cam deformities and the frequency and severity of osteoarthritis progression; and (3) to characterize hip pain and function as measured by the Harris hip score (HHS) and the Hip Disability and Osteoarthritis Outcome Score (HOOS) at minimal 10-year followup. Read More

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December 2018

Return to Sport After Ankle Syndesmotic Injury: A Systematic Review.

Sports Health 2018 Dec 14:1941738118816282. Epub 2018 Dec 14.

Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.

Context:: Ankle syndesmotic injuries present a significant challenge for athletes due to prolonged disability and recovery periods. The optimal management of these injuries and rates of return to sport in athletes remains unclear.

Objective:: The purpose of this study was to evaluate return to sport for athletes after ankle syndesmotic injuries. Read More

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December 2018

Windows to functional decline: Naturalistic eye movements in older and younger adults.

Psychol Aging 2018 Dec;33(8):1215-1222

Department of Communication Sciences and Disorders, Temple University.

Subtle changes in everyday tasks precede and predict future disability in older adults. Eye tracking may provide a sensitive tool for detecting subtle disruption of everyday task performance and informing the mechanism(s) of breakdown. We tracked eye movements of healthy older adults (OA, n = 24) and younger adults (YA, n = 25) while they passively viewed a naturalistic scene (Passive Viewing condition) and then verbally reported the necessary steps for achieving a task goal (e. Read More

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December 2018
1 Read

Rehabilitation in systemic sclerosis: proposed personalised rehabilitation programme.

G Ital Med Lav Ergon 2018 Dec;40(4):248-256

Physical Medicine and Rehabilitation Unit, IRCCS Policlinico San Matteo Foundation, Pavia, Italy; University of Pavia, Italy.

Objectives: Systemic sclerosis is a multisystem autoimmune disease that causes chronic widespread obliterative vasculopathy of the small arteries associated with various degrees of tissue fibrosis. The prognosis of the disease depends largely on the visceral involvement; however musculoskeletal involvement is an important factor to functional disability. Suffering from a chronic auto-immune disease, such as Systemic Sclerosis, compromises the quality of life and the work ability. Read More

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December 2018

[Validation of a short Spanish version of the instrument Barriers to Physical Activity Questionnaire for People with Mobility Impairments.]

Salud Publica Mex 2018 Sep-Oct;60(5):539-548

Departamento de Educación Física y Deportiva, Universitat de València. España.

Objective: To validate a short Spanish version of the instrument Barriers to Physical Activity Questionnaire for People with Mobility Impairments (BPAQ-MI), applicable to different types of disability.

Materials And Methods: The questionnaire was administered to 791 university students with disabilities. The factorial structure was validated by confirmatory factor analysis and Spearman correlations were carried out to assess criterion validity. Read More

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February 2017

The Efficacy of Intravenous Immunoglobulin in Guillain-Barré Syndrome: The Experience of a Tertiary Medical Center.

Isr Med Assoc J 2018 Dec;20(12):754-760

Borenstein Talpiot Medical Leadership Program, 2013, Sheba Medical Center, Tel Hashomer, Israel.

Background: Guillain-Barré syndrome (GBS) is an autoimmune disease of the peripheral nervous system with a typical presentation of acute paralysis and hyporeflexia. Intravenous immunoglobulin (IVIG) and plasma exchange (PLEX) are treatments that have proven to expedite recuperation and recovery of motor function.

Objectives: To describe our experience at one tertiary medical center treating GBS with IVIG and to compare the efficacy of IVIG as the sole treatment versus combined therapy of IVIG and plasma exchange. Read More

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December 2018

Comparative study between Plate-Graff, Plate-Cage and peek cage in cervical spine fusion.

Acta Ortop Mex 2018 Jul-Aug;32(4):203-208

Spine Surgery Service. National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra. Mexico City. Mexico.

Objective: To compare results of Plate-Graff, Plate-Cage and PEEK cage in patients with cervical stenosis.

Material And Methods: Prospective, with before and after intervention and comparative study. From January 2005 to October 2011 we included 37 patients (male: 48. Read More

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December 2018

What Should a Psychiatrist Know About Genetics? Review and Recommendations From the Residency Education Committee of the International Society of Psychiatric Genetics.

J Clin Psychiatry 2018 Nov 27;80(1). Epub 2018 Nov 27.

Centre for Addiction and Mental Health and University of Toronto, Toronto, Ontario, Canada.

The International Society of Psychiatric Genetics (ISPG) created a Residency Education Committee with the purpose of identifying key genetic knowledge that should be taught in psychiatric training programs. Thirteen committee members were appointed by the ISPG Board of Directors, based on varied training, expertise, gender, and national origin. The Committee has met quarterly for the past 2 years, with periodic reports to the Board and to the members of the Society. Read More

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November 2018

Cognitive Deficits in the THINC-Integrated Tool (THINC-it) Are Associated With Psychosocial Dysfunction in Patients With Major Depressive Disorder.

J Clin Psychiatry 2018 Nov 20;80(1). Epub 2018 Nov 20.

Department of Psychiatry, Melbourne Medical School, University of Melbourne, Parkville, VIC 3010, Melbourne, Australia.

Objective: To evaluate the extent to which cognitive measures in the recently developed THINC-integrated tool (THINC-it) are associated with global and domain specific psychosocial disability in patients with current and remitted major depressive disorder (MDD).

Methods: Cross-sectional data (N = 127) were obtained from participants with current (n = 105) or remitted (n = 22) MDD who completed the THINC-it between July 2014 and June 2018. Major depressive disorder was diagnostically assessed with DSM-IV and DSM-5 criteria. Read More

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November 2018
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Ambulatory Care Sensitive Admissions in Individuals With Autism Spectrum Disorder, Intellectual Disability, and Population Controls.

Autism Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.

Ambulatory care sensitive (ACS) admissions are those for which effective primary care can prevent the need for emergency department (ED) visits and inpatient hospitalizations, and are an indicator of primary care access. Individuals with autism spectrum disorder (ASD) and/or intellectual disability (ID) may be at higher risk for ACS admissions than individuals in the general population due to difficulty accessing primary care. The objective of this study was to compare the incidence of ACS admissions among four cohorts of individuals aged 2-24 years: ASD without co-occurring ID (ASD-only), ASD with co-occurring ID (ASD + ID), ID without ASD (ID-only), and population controls (PC). Read More

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December 2018

A case of YY1-associated syndromic learning disability or Gabriele-de Vries syndrome with myasthenia gravis.

Am J Med Genet A 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurology, Mayo Clinic, Mayo Clinic, Scottsdale, Arizona.

Exome sequencing is being used increasingly to evaluate patients with intellectual disability. YY1 is a ubiquitously distributed transcription factor belonging to the GLIKruppel class of zinc finger proteins recently recognized as the causative gene in 23 patients for the Gabriele-de Vries syndrome. We report a new case with similar features and a novel variant in YY1, in a region of the gene, which has not previously been reported. Read More

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December 2018

GPR126: A novel candidate gene implicated in autosomal recessive intellectual disability.

Am J Med Genet A 2018 Dec 14. Epub 2018 Dec 14.

Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

Intellectual disability (ID), a genetically and clinically heterogeneous disorder, affects 1%-3% of the general population and is a major health problem, especially in developing countries and in populations with a high frequency of consanguineous marriage. Using whole exome sequencing, a homozygous missense variation (c.3264G>C, p. Read More

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December 2018

The progression of Wiedemann-Steiner syndrome in adulthood and two novel variants in the KMT2A gene.

Am J Med Genet A 2018 Dec 14. Epub 2018 Dec 14.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.

Wiedemann-Steiner syndrome is a genetic condition associated with dysmorphic facies, hypertrichosis, short stature, developmental delay, and intellectual disability. Congenital malformations of the cerebral, cardiac, renal, and optic structures have also been reported. Because the majority of reported individuals with this condition have been under age 20, the long-term prognosis is not well defined. Read More

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December 2018

Optic Disc Coloboma in children - prevalence, clinical characteristics and associated morbidity.

Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Purpose: The aim of the study was to report prevalence, ocular outcome, neurological characteristics, cognitive and behavioural problems in children with optic disc coloboma (ODC).

Methods: This was a population-based, cross-sectional study of 31 children between 2 and 18 years of age diagnosed with ODC. The children were part of a larger cohort of 184 children with congenital optic disc malformations. Read More

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December 2018
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The centrality of health behaviours: A network analytic approach.

Br J Health Psychol 2018 Dec 13. Epub 2018 Dec 13.

School of Psychological Sciences, Tel Aviv University, Israel.

Objectives: Since behavioural risk factors are the foremost causes of disability and premature mortality, developing new perspectives for understanding them is of utmost importance. This paper describes an innovative approach that conceptualizes health-related behaviours as nodes in a weighted network.

Design & Methods: Using self-reported data from a representative sample (n = 374), a network of 37 health behaviours was analysed, with the aim of identifying 'central' nodes, that is, behaviours that are likely to co-occur with others and potentially influence them. Read More

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December 2018

The effect of body condition on postoperative recovery of dachshunds with intervertebral disc disease treated with postoperative physical rehabilitation.

Vet Surg 2018 Dec 13. Epub 2018 Dec 13.

College of Veterinary Medicine, University of Illinois, Urbana-Champaign, Illinois.

Objective: To determine the impact of obesity on postoperative recovery from thoracolumbar hemilaminectomy in dachshunds treated with rehabilitation.

Study Design: Prospective observational trial.

Animals: Thirty-two dachshunds with thoracolumbar intervertebral disk disease and pain perception. Read More

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December 2018
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Veterinary-focused assessment with sonography for trauma-airway, breathing, circulation, disability and exposure: a prospective observational study in 64 canine trauma patients.

J Small Anim Pract 2018 Dec 13. Epub 2018 Dec 13.

Lodi's ICU and Sub ICU Head, ASST Lodi 26900, Italy.

Objective: To describe the technique and findings of the 'veterinary focused assessment with sonography for trauma-airway, breathing, circulation, disability and exposure' protocol in dogs suffering from trauma.

Materials And Methods: Prospective observational study on a new point-of-care ultrasound protocol on 64 dogs suffering from trauma and comparison of findings with radiology.

Results: Comparison of the results of this new ultrasound protocol for trauma patients with radiography findings for pneumothorax, pleural effusion, alveolar-interstitial syndrome and abdominal effusion revealed positive agreement of 89, 83, 100 and 87% and negative agreement of 76, 83, 76 and 92%, respectively. Read More

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December 2018
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Illness Perception and Job Satisfaction in Patients Suffering from Migraine Headaches: Trait Anxiety and Depressive Symptoms as Potential Mediators.

Headache 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, S. Andrea Hospital, Sapienza University, Rome, Italy.

Background And Objectives: Migraine headache is the seventh leading cause of disability worldwide causing adverse outcomes in many aspects of an individual's life. Many psychological aspects affect chronic migraine (CM): illness perception, anxiety, depressive symptoms, and job satisfaction. This observational study aimed to examine the association among illness perception, anxiety, depressive symptoms, and job satisfaction, connected to migraine and its features. Read More

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December 2018

Resolving reading disability-Childhood predictors and adult-age outcomes.

Dyslexia 2018 Dec 12. Epub 2018 Dec 12.

Niilo Mäki Institute, Jyväskylä, Finland.

We examined frequency of adult-age reading disability (RD) and its childhood predictors among 48 adults (20 to 39 years) with documented childhood RD, and contrasted their cognitive skills, education, and employment with 37 matched controls. Among individuals with childhood RD, more than half had improved in their reading fluency to the level where the set criterion for adult-age RD was not met anymore. More fluent rapid naming, less severe childhood RD, and multiple support providers in childhood together predicted improvement of reading fluency. Read More

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December 2018