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Workplace Exposure to Nanoparticles during Thermal Spraying of Ceramic Coatings.

Ann Work Expo Health 2018 Dec 14. Epub 2018 Dec 14.

Institute of Environmental Assessment and Water Research (IDAEA-CSIC), Barcelona, Spain.

Thermal spraying is widely used for industrial-scale application of ceramic coatings onto metallic surfaces. The particular process has implications for occupational health, as the high energy process generates high emissions of metal-bearing nanoparticles. Emissions and their impact on exposure were characterized during thermal spraying in a work environment, by monitoring size-resolved number and mass concentrations, lung-deposited surface area, particle morphology, and chemical composition. Read More

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December 2018

Disease Severity and Depressive Symptoms in Adolescents With Inflammatory Bowel Disease: The Mediating Role of Parent and Youth Illness Uncertainty.

J Pediatr Psychol 2018 Dec 14. Epub 2018 Dec 14.

Oklahoma State University.

Objective: The objective of this study is to examine parent and youth appraisals of illness uncertainty as potential serial mediators in the relation between disease severity and youth depressive symptoms in adolescents with inflammatory bowel disease (IBD).

Methods: Participants were 85 adolescents 13-18 years of age (Mage = 15.75, SD =1. Read More

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December 2018

Physiological response and mineral elements accumulation pattern in Sesuvium portulacastrum L. subjected in vitro to nickel.

Chemosphere 2018 Dec 10;219:463-471. Epub 2018 Dec 10.

Centre de Biotechnologie de Borj Cedria (LR15CBBC02), Laboratoire des Plantes Extrèmophiles, BP 901 2050 Hammam-Lif, Tunisia. Electronic address:

Sesuvium portulacastrum, a halophyte with high tolerance to heavy metals like Cd, Pb and Ni is considered for phytoremediation of metal contaminated saline soils. The tolerance to a selected metal ion could, by hypothesis, be stimulated through in vitro adaptation and regeneration of the plant. Seedlings obtained by in vitro micro-propagation, were exposed to 0, 25 and 50 μM Ni, as NiCl, in agar-based medium for 30 days. Read More

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December 2018

Influence of drivers' psychological risk profiles on the effectiveness of traffic calming measures.

Accid Anal Prev 2018 Dec 11;123:243-255. Epub 2018 Dec 11.

Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Via Paradisa 2, 56126, Pisa, Italy.

Road traffic injuries represent a serious public health problem and are one of leading cause of death, injury and disability around the world. Road accidents are often caused by an accumulation of factors; however, drivers appear to be by far the most decisive one. The driver's behaviour is complex and depends on reflex (or involuntary) and voluntary driving actions. Read More

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December 2018

Targeted and untargeted LC-MS polyphenolic profiling and chemometric analysis of propolis from different regions of Croatia.

J Pharm Biomed Anal 2018 Dec 4;165:162-172. Epub 2018 Dec 4.

University of Rijeka, Department of Biotechnology, Centre for high-throughput technologies, Radmile Matejčić 2, 51000 Rijeka, Croatia. Electronic address:

Propolis is a complex biological matrix consisting mostly of plant resins and waxes, and in a small proportion of the herbal secondary metabolites, phenols. Phenols are components that are responsible for biological activities of propolis, however, their qualitative and quantitative composition is strongly influenced by climate and vegetation. Although studies on profiling of propolis samples from different countries have been carried out for some time propolis from Croatia is still not characterized till now. Read More

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December 2018

Vertico-horizontal atlantoaxial index (VHAI): A new craniovertebral radiographic index.

Clin Neurol Neurosurg 2018 Dec 3;176:83-88. Epub 2018 Dec 3.

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Objective: The purpose of this study was to develop a new index that can reliably quantify the reduction of basilar invagination with atlantoaxial dislocation.

Patients And Methods: Between May 2012 and September 2017, 40 patients with congenital basilar invagination and atlantoaxial dislocation as well as 100 sex-and age-matched control subjects were recruited for this study. All patients underwent direct posterior reduction and fixation. Read More

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December 2018

Using tDCS to facilitate motor learning in speech production: The role of timing.

Cortex 2018 Nov 19;111:274-285. Epub 2018 Nov 19.

Burke Medical Research Institute, Edith Cowan University and Weill Cornell Medicine, White Plains, NY, USA; Moss Rehabilitation Research Institute, Philadelphia, PA, USA.

There exists debate regarding the extent to which transcranial direct current stimulation (tDCS) can affect or enhance human behavior. Here, we examined a previously unexplored domain: speech motor learning. We investigated whether speech motor learning in unimpaired participants can be enhanced using a single-session tDCS experiment, and investigated whether the timing of tDCS relative to a behavioral task affected performance. Read More

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November 2018

Ventilator-associated pneumonia: The central role of transcolonization.

J Crit Care 2018 Dec 6;50:155-161. Epub 2018 Dec 6.

Medical and Surgical Intensive Care Unit, Groupe Hospitalier Paris Saint Joseph, Paris, France; Endotoxins, Structures and Host Response, Department of Microbiology, Institute for Integrative Biology of the Cell, UMR 9891 CNRS-CEA-Paris Saclay University, 98190 Gif-sur-Yvette, France. Electronic address:

Ventilator-associated pneumonia remain frequent and serious diseases since they are associated with considerable crude mortality. Pathophysiology is centered on modifications of regional bacterial flora, especially tracheobronchial tree and oropharyngeal sphere. Bacterial migration from an anatomical area to another seems to be the main explanation of these alterations which are called "transcolonization". Read More

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December 2018

Direct potentiation of NK cell cytotoxicity by 8-azaguanine with potential antineoplastic activity.

Int Immunopharmacol 2018 Dec 11;67:152-159. Epub 2018 Dec 11.

Department of Biomedical Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea; Microbiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea; Stem Cell Immunomodulation Research Center (SCIRC), Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea. Electronic address:

This study identified 8-azaguanine (8-AG) as a novel immunomodulatory drug (IMiD) through a high-throughput screen of the Preswick Chemical Library in a model of human NK cell cytotoxicity against blood cancer cells. 8-AG, originally developed as an antineoplastic agent, significantly increased the cytotoxicity of NK cells and was superior in this activity to previously known IMiDs, such as fluoxetine and amphotericin B, identified from the same library. IFN-γ expression was also slightly increased by 8-AG. Read More

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December 2018

A novel pro-apoptotic role of zinc octacarboxyphthalocyanine in melanoma me45 cancer cell's photodynamic therapy (PDT).

J Photochem Photobiol B 2018 Dec 5;190:146-153. Epub 2018 Dec 5.

Biosystems Group, Institute of Automatic Control, Silesian University of Technology, Akademicka 16, 44-100 Gliwice, Poland; Biotechnology Centre, Silesian University of Technology, Krzywoustego 8, 44-100 Gliwice, Poland. Electronic address:

Zn-based phthalocyanine acts as drug or photosensitizer in photodynamic therapy (PDT) for the treatment of cancer cells. The activated zinc octacarboxyphthalocyanine (ZnPcOC) reacts with oxygen, to generate reactive oxygen species for the damage of melanoma cancer cells, Me45. This in vitro study aimed at investigating the cytotoxic effects of different concentrations of ZnPcOC activated with a diode laser (λ = 685 nm) on Me45, and normal human fibroblast cells, NHDF. Read More

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December 2018

Neutral/negative α-AR antagonists and calcium channel blockers at comparison in functional tests on guinea-pig smooth muscle and myocardium.

Pharmacol Rep 2018 Oct 11;71(1):128-132. Epub 2018 Oct 11.

Dipartimento di Farmacia e Biotecnologie, Università degli Studi di Bologna, Bologna, Italy. Electronic address:

Background: Constitutive (agonist-independent) activity is a prerogative of many G protein-coupled receptors (GPCRs) including α-adrenoceptors (α-ARs). Inhibition of such an activity at α-AR subtypes by antagonists with negative efficacy is difficult to be adequately tested.

Methods: In the present experimental approach, we compared the activity of three calcium channel blockers (nifedipine, diltiazem and verapamil) and of three potent benzodioxane-based α-AR antagonists, differing for subtype selectivity and inverse agonist properties, in producing smooth muscle relaxation and negative inotropy under the same test conditions. Read More

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October 2018

Fish antiviral tripartite motif (TRIM) proteins.

Fish Shellfish Immunol 2018 Dec 11. Epub 2018 Dec 11.

INRA, Virologie et Immunologie Moléculaires, Université Paris-Saclay, Jouy-en-Josas, France. Electronic address:

Tripartite motif (TRIM) family or RBCC proteins comprises characteristic zinc-binding domains (a RING (R), a B-box type 1 (B1) and a B-box type 2 (B2)) and coiled-coil (CC) domain followed by a C-terminus variable domain. There are about 80 different TRIM proteins in human, but more than 200 in zebrafish with several large gene expansions (ftr >70 genes; btr >30 genes; trim35 > 30 genes). Repertoires of trim genes in fish are variable across fishes, but they have been remarkably diversified independently in a number of species. Read More

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December 2018

The effects of unintentional and intentional process disturbances on tablet quality during long continuous manufacturing runs.

Eur J Pharm Sci 2018 Dec 11. Epub 2018 Dec 11.

School of Pharmacy, Promis Centre, University of Eastern Finland, Kuopio, Finland. Electronic address:

Several kinds of process disturbances can occur during (continuous) tablet manufacturing, i.e. unintentional or intentional disturbances. Read More

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December 2018

CircRNAs and cancer: biomarkers and master regulators.

Semin Cancer Biol 2018 Dec 11. Epub 2018 Dec 11.

Molecular Oncology group, Biodonostia Research Institute, Paseo Doctor Begiristain, s/n San Sebastián, 20014, Spain; Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom; IKERBASQUE, Basque Foundation for Science, María Díaz Haroko Kalea, 3, 48013, Bilbao, Spain. Electronic address:

Circular RNAs (circRNAs) are a novel class of regulatory RNAs that despite being relatively abundant have only recently begun to be explored. There are many thousands of genes that appear capable of producing circRNAs, however the function of all but a handful remain to be determined. What is emerging about these highly conserved molecules is that they play important roles in biology and cancer biology in particular. Read More

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December 2018
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Targeting STATs in neuroinflammation: the Road Less Traveled!

Pharmacol Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Pharmacology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

JAK/STAT transduction pathway is a highly conserved pathway implicated in regulating cellular proliferation, differentiation, survival and apoptosis. Dysregulation of this pathway is involved in the onset of autoimmune, haematological, oncological, metabolic and neurological diseases. Over the last few years, the research of anti-neuroinflammatory agents has gained considerable attention. Read More

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December 2018
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Microfluidic assembly of hydrogel-based immunogenic tumor spheroids for evaluation of anticancer therapies and biomarker release.

J Control Release 2018 Dec 11. Epub 2018 Dec 11.

Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA. Electronic address:

Diffuse large B cell lymphoma (DLBCL), the most common subtype of Non-Hodgkin lymphoma, exhibits pathologic heterogeneity and a dynamic immunogenic tumor microenvironment (TME). However, the lack of preclinical in vitro models of DLBCL TME hinders optimal therapeutic screening. This study describes the development of an integrated droplet microfluidics-based platform for high-throughput generation of immunogenic DLBCL spheroids. Read More

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December 2018
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Toll-like receptor 3 activation increases voluntary alcohol intake in C57BL/6J male mice.

Brain Behav Immun 2018 Dec 11. Epub 2018 Dec 11.

Waggoner Center for Alcoholism and Addiction Research, University of Texas at Austin, Austin, TX 78712, USA; Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA.

Many genes differentially expressed in brain tissue from human alcoholics and animals that have consumed large amounts of alcohol are components of the innate immune toll-like receptor (TLR) pathway. TLRs initiate inflammatory responses via two branches: [1] MyD88-dependent or [2] TRIF-dependent. All TLRs signal through MyD88 except TLR3. Read More

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December 2018

LncRNA PMS2L2 protects ATDC5 chondrocytes against lipopolysaccharide-induced inflammatory injury by sponging miR-203.

Life Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedics, Affiliated Hospital of Jining Medical University, Jining 272029, China. Electronic address:

Aims: PMS1 Homolog 2, Mismatch Repair System Component Pseudogene 2 (PMS2L2) has been reported as an up-regulated long non-coding RNA (lncRNA) in osteoarthritis (OA) tissues. The purpose of the present work is to explore whether the differently expressed PMS2L2 is associated with the pathogenesis of OA.

Main Methods: Chondrogenic ATDC5 cells were exposed to various doses of lipopolysaccharide (LPS). Read More

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December 2018

Role of the androgen receptor gene CAG repeat polymorphism on the sequence of pubertal events and adiposity in girls with high dehydroepiandrosterone sulfate.

J Pediatr Adolesc Gynecol 2018 Dec 11. Epub 2018 Dec 11.

Institute of Maternal and Child Research, School of Medicine, University of Chile, Santiago, Chile. Electronic address:

Study Objective: The Androgen Receptor (AR) harbors a variable repeat of a variable number of glutamine residues [(CAG)n] which seems to affect inversely AR transcriptional activity. We assessed whether (CAG)n affect the sequence of the androgen-sensitive pubertal events and body composition in prepubertal girls.

Design: and participants: Nested case-control study within the Growth and Obesity Cohort Study of 1196 low-middle income children (≈50% girls) from Santiago, Chile. Read More

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December 2018
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Dependence of initial silica scaling on the surface physicochemical properties of reverse osmosis membranes during bench-scale brackish water desalination.

Water Res 2018 Nov 30;150:358-367. Epub 2018 Nov 30.

School of Environment, Beijing Normal University, No. 19, Xinjiekouwai Street, Beijing, 100875, China; Department of Environmental Health and Engineering, Bloomberg School of Public Health, The John Hopkins University, 615 North Wolfe Street, MD, 21205, USA. Electronic address:

Silica scaling of reverse osmosis membranes in brackish water desalination is less understood than hardness scaling due to the complex silica behaviors at the membrane/water interface. In this study, -COOH, -SOH, -NH and -OH functional groups were introduced onto polyamide membranes to create distinct surface physicochemical properties. The resulting membranes were further studied under similar scaling conditions to yield temporal flux loss data that were empirically interpreted by a logistic growth model. Read More

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November 2018

A New Model to Predict Ischemic Stroke in Patients with Atrial Fibrillation Using Warfarin or Direct Oral Anticoagulants.

Heart Rhythm 2018 Dec 11. Epub 2018 Dec 11.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.

Background: Stroke risk stratification scores (e.g., CHADS-VASc) are used to tailor therapeutic recommendations for patients with atrial fibrillation (AF) in different risk groups. Read More

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December 2018
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Recovery of metabolic impairment of patients who cleared HCV infections after direct-acting antiviral therapy.

Int J Antimicrob Agents 2018 Dec 11. Epub 2018 Dec 11.

National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS- Via Portuense, 292- 00149 Rome, Italy. Electronic address:

Chronic Hepatitis C (CHC) is a complex disease that can affect different metabolic processes, including glucose and lipids metabolic pathways, with a significant impact on development of heart disease and stroke. The recent therapy with Direct Antiviral Agents (DAAs) beyond the high efficacy on CHC eradication, showed a beneficial impact on glucose and lipid metabolism. This review aims to describe current evidences about the association between HCV infection and impairment of glucose and lipids metabolism and discuss potential public health implications at the light of new DAA therapy and their availability at global level. Read More

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December 2018

Combined Raman- and AFM-based detection of biochemical and nanomechanical features of endothelial dysfunction in aorta isolated from ApoE/LDLR-/- mice.

Nanomedicine 2018 Dec 11. Epub 2018 Dec 11.

Institute of Physiology II, University of Münster, Münster, Germany; Institute of Physiology, University of Lübeck, Lübeck, Germany. Electronic address:

Endothelial dysfunction is recognized as a critical condition in the development of cardiovascular disorders. This multifactorial process involves changes in the biochemical and mechanical properties of endothelial cells leading to disturbed release of vasoprotective mediators. Hypercholesterolemia and increased stiffness of the endothelial cortex are independently shown to result in reduced release of nitric oxide and thus endothelial dysfunction. Read More

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December 2018

Clinicopathological and molecular analysis of multinodular and vacuolating neuronal tumors of the cerebrum.

Hum Pathol 2018 Dec 11. Epub 2018 Dec 11.

Department of Pathology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Neuroscience, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Multinodular and vacuolating neuronal tumor (MVNT) of the cerebrum is a recently recognized rare neuronal tumor, and its pathogenesis is unclear. We analyzed 7 cases of histologically typical MVNT: six were adults [mean age: 43.0years (range: 23-56)] and one was a child (10-year-old). Read More

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December 2018

Comparison of stool examination techniques to detect Opisthorchis viverrini in low intensity infection.

Acta Trop 2018 Dec 11. Epub 2018 Dec 11.

Department of Parasitology, Phramongkutklao College of Medicine, Bangkok, 10400, Thailand. Electronic address:

Opisthorchiasis, caused by Opisthorchis viverrini, remains the public health significance in Thailand, particularly in the northeastern region. Number of parasitological techniques is available for diagnosis. However, the detection the parasite's eggs in stool still referred as gold standard. Read More

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December 2018

Delivering in-school interventions to improve dietary behaviours amongst 11- to 16-year-olds: A systematic review.

Obes Rev 2018 Dec 14. Epub 2018 Dec 14.

The Staffordshire Centre for Psychological Research and Centre for Health Psychology, Staffordshire University, Stoke-on-Trent, UK.

Childhood obesity is a global health concern, which has both short- and long-term health consequences for the individual, and is a potential burden on health care services and the wider economy. The school environment is a setting where changes can be applied to dietary behaviours, as schools have direct and intensive contact with children. This systematic review evaluated school-based interventions designed to improve dietary behaviours among adolescents (11- to 16-year-olds). Read More

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December 2018
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Reversing wetland death from 35,000 cuts: Opportunities to restore Louisiana's dredged canals.

PLoS One 2018 14;13(12):e0207717. Epub 2018 Dec 14.

University of Central Florida, Orlando, Florida, United States of America.

We determined the number of permits for oil and gas activities in 14 coastal Louisiana parishes from 1900 to 2017, compared them to land loss on this coast, and estimated their restoration potential. A total of 76,247 oil and gas recovery wells were permitted, of which 35,163 (46%) were on land (as of 2010) and 27,483 of which are officially abandoned. There is a direct spatial and temporal relationship between the number of these permits and land loss, attributable to the above and belowground changes in hydrology resulting from the dredged material levees placed parallel to the canal (spoil banks). Read More

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December 2018
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Musculoskeletal injuries and absenteeism among healthcare professionals-ICD-10 characterization.

PLoS One 2018 14;13(12):e0207837. Epub 2018 Dec 14.

Department of Occupational Health, Centro Hospitalar Universitário São João, Porto, Portugal.

Introduction: Healthcare workers account for 10% of the EU's total workforce, with a significant proportion of those employed in hospitals. Musculoskeletal injuries are the predominant group of injuries in healthcare professionals due to the physical demands of their work, such as the mobilization and positioning of the dependent patients. The management of this type of problem should take into account direct and indirect costs, such as periods of incapacity for work due to illness, hiring and training of new employees during periods of absence, reduced levels of productivity and the effects on production and quality of work. Read More

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December 2018
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Economic impact of dengue in Mexico considering reported cases for 2012 to 2016.

PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006938. Epub 2018 Dec 14.

Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.

Background: Given that dengue disease is growing and may progress to dengue hemorrhagic fever (DHF), data on economic cost and disease burden are important. However, data for Mexico are limited.

Methodology/principal Findings: Burden of dengue fever (DF) and DHF in Mexico was assessed using official databases for epidemiological information, disabilities weights from Shepard et al, the reported number of cases and deaths, and costs. Read More

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December 2018

Effects of Intimate Partner Violence and Home Environment on Child Language Development in the First 3 Years of Life.

J Dev Behav Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH.

Objective: Intimate partner violence (IPV) can adversely affect children's cognitive development, but links between IPV exposure and language development in the earliest years of life remain unknown. The present study examined the effects of IPV and the quality of the home environment on children's language development at age 3 years.

Methods: In a prospective, 5-panel, longitudinal study of 79 mother-child dyads assessed prenatally to age 3 years, we examined standardized measures of receptive and expressive language development at age 3 years. Read More

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December 2018
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Diagnostic Value of the Magnetic Resonance Imaging With Intratympanic Gadolinium Administration (IT-Gd MRI) Versus Audio-Vestibular Tests in Menière's Disease: IT-Gd MRI Makes the Difference.

Otol Neurotol 2018 Dec 13. Epub 2018 Dec 13.

Albers-Schönberg Institute for Radiology in Hamburg, Germany.

Objective: Our aim was to evaluate the validity and reliability of clinically relevant tests in the diagnosis of Menière's disease (MD) according to the criteria formulated during 2015 as well as their efficacy in detecting endolymphatic hydrops (EH). The focus was on: three-dimensional fluid-attenuated inversion recovery-SPectral Attenuated Inversion Recovery (3D-FLAIR-SPAIR) sequences using 3 Tesla magnetic resonance imaging (3T MRI) performed 24 hours after intratympanic Gadolinium injection (IT-Gd) in comparison with the functional tests pure tone audiometry (PTA), caloric test, video head impulse test (vHIT), and cervical-vestibular-evoked-myogenic-potentials (cVEMP).

Study Design: Retrospective study. Read More

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December 2018

Osseointegrated Percutaneous Prosthetic System for the Treatment of Patients With Transfemoral Amputation: A Prospective Five-year Follow-up of Patient-reported Outcomes and Complications.

J Am Acad Orthop Surg 2018 Dec 13. Epub 2018 Dec 13.

From the Centre for Advanced Reconstruction of Extremities (C.A.R.E.), Sahlgrenska University Hospital, Department of Orthopaedics, Institute for Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden (Dr. Brånemark, Dr. Hagberg, Mrs. Kulbacka-Ortiz, and Dr. Berlin), International Centre for Osseointegration Research, Education and Surgery (iCORES), Department of Orthopaedics, University of California, San Francisco, CA (Dr. Brånemark), and the Sahlgrenska University Hospital, Department of Orthopaedics, Institute for Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden (Dr. Rydevik).

Introduction: Direct skeletal attachment of prostheses has previously been shown to improve patient-reported outcome (PRO) measures of individuals with transfemoral amputation (TFA) at 2-year follow-up. This prospective study reports the outcomes at 5-year follow-up.

Methods: A total of 51 patients (55 legs) with TFA were included in a prospective study. Read More

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December 2018

The impact of anti-vascular endothelial growth factor agents on visual impairment/blindness prevention in patients with diabetic macular edema and on associated patient and caregiver burden in Japan.

J Med Econ 2018 Dec 14:1-28. Epub 2018 Dec 14.

e Market Access, Health Economics and Outcomes Research , Bayer Yakuhin, Ltd , Tokyo , Japan.

Aims: To estimate the impact of anti-vascular endothelial growth factor (VEGF) agents on visual impairment and blindness avoided in patients with diabetic macular edema (DME) and on associated patient and caregiver productivity loss in Japan.

Methods: We compared the impact of current care (estimated at 53.8% utilization of anti-VEGF agents using current data) with that of hypothetical care (characterized by a higher utilization of anti-VEGF agents [80. Read More

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December 2018
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Molecular diagnostics of disorders of sexual development: an Indian survey and systems biology perspective.

Syst Biol Reprod Med 2018 Dec 14:1-16. Epub 2018 Dec 14.

b Division of Pharmacology and Toxicology , CSIR- Indian Institute of Chemical Technology , Hyderabad , India.

We aimed to survey the monogenic causes of disorders of sex development (DSD) and thereby its prevalence in India. This study revealed mutations resulting in androgen insensitivity syndrome, 5α-reductase type 2 deficiency, and gonadal dysgenesis were commonly reported. Intriguingly, AR deficits were the most prevalent (32 mutations) and of 11/26 missense mutations were in exons 4-8 (encoding ligand binding domain). Read More

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December 2018

Losartan prevents the elevation of blood pressure in adipose-PRR deficient female mice while elevated circulating sPRR activates the renin angiotensin system.

Am J Physiol Heart Circ Physiol 2018 Dec 14. Epub 2018 Dec 14.

Graduate Center for Nutritional Sciences, University of Kentucky, United States.

The deletion of the prorenin receptor (PRR) in adipose tissue elevates systolic blood pressure (SBP) and circulating soluble form of PRR (sPRR) in male mice fed a high-fat diet (HF). However, sex differences in the contribution of adipose-PRR and sPRR to the regulation of the renin-angiotensin system (RAS) in key organs for blood pressure control are undefined. Therefore, we assessed blood pressure and the systemic and intrarenal RAS status in adipose-PRR KO female mice. Read More

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December 2018
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Pulmonary hypertension in patients with a history of intravenous drug use.

Curr Med Res Opin 2018 Dec 14:1-14. Epub 2018 Dec 14.

a Cardiovascular Department , John Hunter Hospital , Newcastle NSW , Australia.

Objective: Pulmonary hypertension may be a consequence of intrinsic elevation in pulmonary vasculature resistance or complicate numerous other conditions affecting the cardiac and respiratory systems. In this review we sought to explore the relationship between pulmonary hypertension and intravenous drug use.

Methods: A narrative review was conducted using PubMed MeSH search with further papers were identified using a standard PubMed search with relevant key terms and various synonyms. Read More

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December 2018
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Evaluation of Carriage with the Analysis of Serogroups, Genogroups and Clonal Complexes among Polish Soldiers.

Pol J Microbiol 2018 ;67(4):493-500

Military Institute of Medicine, Department of Epidemiology and Tropical Medicine , Warsaw , Poland.

Neisseria meningitidis is an etiological factor of invasive meningococcal disease (IMD). This Gram-negative diplococcus is transmitted from person to person via droplets or through a direct physical contact with secretions of infected patients or asymptomatic carriers. The latter account for 5-10% of the general population. Read More

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January 2018

Drug Susceptibility of Non-tuberculous Strains of Isolated from Birds from Poland.

Pol J Microbiol 2018 ;67(4):487-492

Department of Pathology and Veterinary Diagnostics, Warsaw University of Life Sciences , Warsaw , Poland.

Mycobacterioses are a constant problem in backyard poultry, as well as pet birds. To date, no evidence of direct transmission of atypical bacilli between humans has been demonstrated, but it cannot be ruled out that sick animals can be a source of infection for people in their environment. The aim of the study was to identify mycobacteria isolated from birds with diagnosed mycobacteriosis and to determine the susceptibility of mycobacterial isolates from these animals to antituberculous drugs most commonly used in the treatment of mycobacterial infections in humans. Read More

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January 2018
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Sparsity-based photoacoustic image reconstruction with a linear array transducer and direct measurement of the forward model.

J Biomed Opt 2018 Dec;24(3):1-9

Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire, United States.

Photoacoustic (PA) imaging is an emerging imaging technique for many clinical applications. One of the challenges posed by clinical translation is that imaging systems often rely on a finite-aperture transducer rather than a full tomography system. This results in imaging artifacts arising from an underdetermined reconstruction of the initial pressure distribution (IPD). Read More

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December 2018

[The Good Samaritan Donor Experience].

G Ital Nefrol 2018 Dec;35(6)

Psicologa Clinica, Psicoterapeuta Sistemico Relazionale IIPR, Psicologa Clinica Ismett, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione - IRCCS, Palermo.

The need for patients with a chronic kidney failure and on dialysis to embark on a kidney transplant process, poses the challenge to identify alternative and effective surgical strategies to overcome the insufficient number of deceased donors. The purpose is to allow the considerable number of patients on the kidney transplant waiting lists to receive appropriate treatment in time and under the most favorable clinical conditions. Living donation from a significant other is becoming increasingly widespread, on a national and international level. Read More

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December 2018

Identification of a Novel Gene Mutation in a Chinese Pedigree with X-linked Thrombocytopenia.

Clin Lab 2018 Oct;64(11)

Background: X-linked thrombocytopenia (XLT) is a milder form of Wiskott-Aldrich syndrome (WAS), characterized predominantly by thrombocytopenia with small-sized platelets. Mutations in the WAS gene are responsible for the disease. We herein detected a new mutation in the WAS gene responsible for XLT in a 3-generation Chinese pedigree. Read More

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October 2018

The Generation of Hematopoietic Progenitor Cells from Endothelial Cells by Silymarin.

Clin Lab 2018 Oct;64(11)

Background: The generation of hematopoietic cells from endothelial cells may determine a novel approach for the production of blood cells. Regenerative functions of Silymarin, a mixture of polyphenolic flavonoids derived from milk thistle, have previously been reported. The purpose of this study was to investigate the direct effect of Silymarin on conversion of endothelial cells to hematopoietic cells. Read More

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October 2018

Thoracoscopic left apical bisegmentectomy.

Authors:
George Rakovich

Multimed Man Cardiothorac Surg 2018 Dec 5;2018. Epub 2018 Dec 5.

Hôpital Maisonneuve-Rosemont (University of Montreal) 5415, l'Assomption Montréal, QC, H1T 2M4, Canada.

Minimally invasive pulmonary segmentectomy allows adequate oncologic treatment in selected cases while preserving lung parenchyma and minimizing perioperative morbidity and length of hospital stay. It may also be ideal for removing benign obstructive lesions. Most lung segments may be resected as segmentectomies or as partial bisegmentectomies (as is the case for the lingula). Read More

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December 2018

Preoperative serum albumin as a predictor of complications following total hip replacement in patients with rheumatoid arthritis.

Acta Ortop Mex 2018 Jul-Aug;32(4):193-197

Trauma and Orthopaedic Surgery Hospitals. UMAE «Dr. Victorio de la Fuente Narváez», Mexico City.

Background: Rheumatoid arthritis is a chronic inflammatory disease characterized by polyarthritis with progressive articular wear, immunologic abnormalities and increasing physical limitation. Surgical correction with hip replacement comes as a successful solution for patients with advanced articular destruction. Following intervention, surgical site infection (SSI), venous thromboembolism, sepsis, renal and major cardiovascular complications are among the most cited in the literature. Read More

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December 2018

Prenatal alcohol exposure prevalence as measured by direct ethanol metabolites in meconium in a Native American tribe of the southwest.

Birth Defects Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmaceutical Sciences and Community Environmental Health Program, University of New Mexico College of Pharmacy, Albuquerque, New Mexico.

Background: Although fetal alcohol spectrum disorders represent a significant public health problem, Native Americans are underrepresented in population and targeted screening programs. Prior reports suggest that Native American tribal communities may have a higher prevalence of alcohol use during pregnancy; however, systematic examination using ethanol biomarkers is lacking.

Methods: This study utilized data collected through the Navajo Birth Cohort Study (NBCS)-a birth cohort study of a Southwestern tribal community. Read More

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December 2018
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Tolerability and effectiveness of generic direct-acting antiviral drugs in eradication of hepatitis C genotype 4 among Egyptian patients.

Liver Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University Cairo, Egypt.

Background: We investigated tolerability and effectiveness of generic, less expensive direct antiviral drugs in the treatment of hepatitis C virus genotype 4(HCV- GT-4) in an Egyptian cohort.

Patients And Methods: Retrospectively, we analyzed data from 648 patients with HCV-GT4 attending Alexandria Main University Hospital from January 2016 to May 2017 [488 treatment naïve/160 treatment experienced/288 with chronic hepatitis/360 with cirrhosis]. Patients received generic sofosbuvir/ledipasvir (n= 168, treatment naïve = 136, treatment-experienced = 32) or sofosbuvir/daclatasvir (n= 480, treatment naïve = 352, treatment-experienced = 128) ± ribavirin. Read More

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December 2018

The presence of varices in patients after hepatitis C eradication predicts deterioration in the FIB-4 index.

Hepatol Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto.

Aims: The liver function of patients with hepatitis C virus (HCV) infection who obtained sustained virological response (SVR) has been known to improve after HCV eradication. However, a predictor of liver function after SVR has not been definitively identified. The aim of this retrospective study was to identify a predictor of deteriorated liver function and FIB-4 index after SVR was achieved by direct-acting antiviral (DAA) treatment. Read More

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December 2018

Impact of cancer service centralisation on the radical treatment of men with high-risk and locally advanced prostate cancer: A national cross-sectional analysis in England.

Int J Cancer 2018 Dec 14. Epub 2018 Dec 14.

Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine.

In many countries, specialist cancer services are centralised to improve outcomes. We explored how centralisation affects the radical treatment of high-risk and locally advanced prostate cancer in the English NHS. 79,085 patients diagnosed with high-risk and locally advanced prostate cancer in England (April 2014 to March 2016) were identified in the National Prostate Cancer Audit database. Read More

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December 2018

A Cross-linked Conjugated Polymer Photosensitizer Enables Efficient Sunlight-induced Photooxidation.

Angew Chem Int Ed Engl 2018 Dec 13. Epub 2018 Dec 13.

National University of Singapore, Department of Chemical and Biomolecular Engineering, 4 Engineering Drive 4, National University of Singapore, 117585, Singapore, SINGAPORE.

Photooxidation under sunlight has great potentials in organic synthesis, bacterial killing, organic waste treatment, etc. Photosensitizers (PSs) often play a very important role in this process. High 1O2 generation efficiency and excellent photostability under sunlight, as well as easy recyclability are ideal properties for PSs used for photooxidation, which are not easy to achieve simultaneously. Read More

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December 2018
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