10,870 results match your criteria Diplopia


Misdiagnosis of lamotrigine toxicity as posterior circulation transient ischemic attack or stroke.

Epilepsy Behav 2020 Jul 8;111:107284. Epub 2020 Jul 8.

Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States of America. Electronic address:

Purpose: Lamotrigine (LTG) is one of the most used antiseizure medications (ASMs). Titration is indicated for incomplete seizure control, but toxicity with vertigo, ataxia, and diplopia may ensue. Lamotrigine concentration would be the optimal diagnostic test. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107284DOI Listing

A paramedian supracerebellar, infratentorial approach for resection of midbrain tumor.

World Neurosurg 2020 Jul 8. Epub 2020 Jul 8.

Pediatric Division of Neurosurgery, University of California at San Diego. Electronic address:

Brainstem tumors represent formidable lesions for neurosurgical intervention. They should be approached with a thorough understanding of the anatomy and clear sense of surgical goals. A 14-year-old previously healthy female presented with 2 weeks of nausea, headaches, diplopia, and gait instability. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.243DOI Listing

Association Between Compensatory Overaction of the Non-Injured Eye, Measured by HESS Chart and Postoperative Diplopia in Blow-Out Fracture.

J Craniofac Surg 2020 Jul 3. Epub 2020 Jul 3.

Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, Matsumoto, Japan.

In orbital floor fracture, diplopia often persists post-operatively. This study evaluated the association between pre-operative parameters concerning the extent of the injury and post-operative diplopia, using multivariate analysis. A retrospective computed tomography analysis and chart review was performed for patients with punched out orbital floor fracture, who underwent operations during the period from April 2011 to March 2018. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006728DOI Listing

Delayed Ocular Motility Restriction After Endoscopic Sinus Surgery in a Patient With Chronic Rhinosinusitis and an Old Medial Orbital Wall Fracture.

J Craniofac Surg 2020 Jul 3. Epub 2020 Jul 3.

Department of Otorhinolaryngology-Head and Neck Surgery, Maryknoll Hospital, Busan, Republic of Korea.

The orbital complications of endoscopic sinus surgery, including diplopia and ocular motility restriction, are mainly caused by direct injury to the orbital structures. These complications are rare, but can have catastrophic consequences. Symptoms occur immediately after surgery in most cases. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006718DOI Listing

Intrascleral fixation of flanged polypropylene suture(s) for iridodialysis repair.

Retina 2020 Jul 3. Epub 2020 Jul 3.

Department of Ophthalmology, Shanghai Tenth People's Hospital Affiliated to Shanghai Tongji University School of Medicine, Shanghai, China.

Purpose: We will describe a minimally invasive technique for the repair of iridodialysis, without conjunctival dissections, using intrasceral fixation of a 6-0 polypropylene suture with a flanged tip.

Methods: A flange was created at the end of the suture with thermoplasticity. An ab interno passing of the needle attached to the suture was performed through the peripheral part of the iris and was further passed out from the eye 1. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002904DOI Listing

Young patients with divergence insufficiency related to excessive near work.

Strabismus 2020 Jul 10:1-6. Epub 2020 Jul 10.

Department of Ophthalmology, Peking University People's Hospital , Beijing.

The purpose of this study is to explore the relationships between excessive near work and divergence insufficiency esotropia in young adults. A prospective study described a series of young patients with divergence insufficiency esotropia related to excessive near work between 2012 and 2017. The medical records of twelve young patients with divergence insufficiency esotropia and a history of excessive near work were reviewed, and the duration of near work, angle of primary position deviations at distance and at near, and angle of primary position deviations after refraining from near work for 3 months were analyzed. Read More

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http://dx.doi.org/10.1080/09273972.2020.1789676DOI Listing

Correlation between serum anti-TSH receptor autoantibodies (TRAbs) and the clinical feature of Graves' orbitopathy.

J Endocrinol Invest 2020 Jul 9. Epub 2020 Jul 9.

Department of Clinical and Experimental Medicine, Endocrinology Unit II, University of Pisa and University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy.

Background: Graves' orbitopathy (GO) is the most common extrathyroidal manifestation of Graves' disease (GD). Several studies support the involvement of TSH receptor autoantibodies (TRAbs) in the pathogenesis of GO, and a correlation between GO features and TRAbs has been reported, but not confirmed by all studies. Thus, we conducted a cross-sectional investigation to determine whether there is a correlation between TRAbs and the clinical features of GO in an initial phase of the eye disease. Read More

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http://dx.doi.org/10.1007/s40618-020-01353-yDOI Listing

Radiosurgery vs. microsurgery for newly diagnosed, small petroclival meningiomas with trigeminal neuralgia.

Neurosurg Rev 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurosurgery, Gangnam Severance Hospital, Yonsei University Health System, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Republic of Korea.

Trigeminal neuralgia (TN) is an excruciating pain that can occur with petroclival meningiomas (PCMs). Gamma knife radiosurgery (GKRS) is an appealing option for small PCMs, but the role of microsurgery (MS) compared to GKRS is not well defined for small PCMs with regard to TN relief. From January 2009 to September 2019, 70 consecutive patients were treated by GKRS or MS for newly diagnosed, small (< 3. Read More

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http://dx.doi.org/10.1007/s10143-020-01346-8DOI Listing

Long term follow up after transorbital penetrating injury: A case report.

Am J Ophthalmol Case Rep 2020 Sep 24;19:100792. Epub 2020 Jun 24.

University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Purpose: Traumatic brain injury is the leading cause of mortality and disability among young individuals. Unfortunately, there are few publications concerning long term follow up of patients with these types of injuries. We present a case of trans-orbital penetrating brain injury with an 18 year follow up. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334582PMC
September 2020

Surgical Approach to Orbital Floor Fractures: Comparing Complication Rates Between Subciliary and Subconjunctival Approaches.

Craniomaxillofac Trauma Reconstr 2020 Mar 16;13(1):45-48. Epub 2020 Mar 16.

Division of Plastic and Reconstructive Surgery, Department of Surgery, Loyola University Medical Center, Maywood, IL, USA.

Background: There are multiple approaches to repairing orbital floor fractures. This study compares the postoperative complications of the subciliary and transconjunctival approaches.

Methods: The electronic medical records from 2 hospitals were screened for CPT codes associated with orbital floor reconstruction. Read More

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http://dx.doi.org/10.1177/1943387520904893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311850PMC

[Unilateral ptosis induced by pure midbrain infarction: a case report].

Rinsho Shinkeigaku 2020 Jul 7. Epub 2020 Jul 7.

Department of Neurology, Sapporo Medical University School of Medicine.

We describe herein a case with left-side ptosis induced by pure midbrain infarction in a 49-year-old woman. She also presented with diplopia and right-side cerebellar ataxia. MRI demonstrated new ischemic stroke of the left ventral paramedian midbrain. Read More

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http://dx.doi.org/10.5692/clinicalneurol.60.cn-001397DOI Listing

Neurovascular Behçet's Disease Presenting with Cavernous Sinus Thrombosis: A Rare Case of Assumed Tolosa-Hunt-Like Syndrome.

Arch Rheumatol 2020 Mar 25;35(1):128-131. Epub 2019 Jun 25.

Department of Internal Medicine, Wonkwang University Hospital, Iksan, South Korea.

Behçet's disease (BD) is a rare, chronic, auto-inflammatory disorder of unknown origin. Mucocutaneous lesions and pan-uveitis constitute the hallmark of BD. Additionally, vessels of all sizes and types are affected. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2020.7351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322304PMC

A case of neurosarcoidosis presenting with multiple cranial neuropathies.

Am J Ophthalmol Case Rep 2020 Sep 27;19:100796. Epub 2020 Jun 27.

Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Purpose: We report a case of neurosarcoidosis that presented simultaneously with oculomotor nerve palsy, contralateral abducens nerve palsy, and paresthesia of both lower limbs.

Observations: A 69-year-old Japanese woman who suffered from repeated diplopia and lower-limb paresthesia was referred to our hospital. Ophthalmic findings included oculomotor nerve and contralateral abducens nerve palsies. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330492PMC
September 2020

Teprotumumab: a disease modifying treatment for graves' orbitopathy.

Thyroid Res 2020 4;13:12. Epub 2020 Jul 4.

Adnexal Department, Moorfields Eye Hospital NHS Foundation Trust, 162 City Road, London, EC1V 2PD UK.

Background: On 21st January 2020, the FDA approved Tepezza (teprotumumab-trbw) for the treatment of active Graves' orbitopathy (GO) in adults. This approval was based on positive results from two multinational randomised double-blind placebo-controlled clinical trials.

Discussion: This article discusses the outcomes of those trials and the potential role of teprotumumab in altering current treatment paradigms in Graves' orbitopathy. Read More

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http://dx.doi.org/10.1186/s13044-020-00086-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334856PMC

Rare neurovascular conflict between oculomotor nerve and posterior communicating artery.

Neuroradiology 2020 Jul 6. Epub 2020 Jul 6.

Department of Neurosurgery, Neurocenter of the Southern Switzerland, Lugano, Switzerland.

Paroxysmal diplopia could be the expression of a multitude of clinical or anatomical conditions. Both ophthalmological and neurological pathologies could be responsible of this symptom. Rarely, a neurovascular conflict involving the oculomotor nerve is the etiology. Read More

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http://dx.doi.org/10.1007/s00234-020-02489-7DOI Listing

Reversal of severe vergence anomaly associated with convergence insufficiency.

J AAPOS 2020 Jul 1. Epub 2020 Jul 1.

Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California. Electronic address:

Central disruption of fusion refers to a subject's inability to align images, resulting in constant diplopia. Severely reduced vergences, or vergence anomalies, producing markedly decreased fusional amplitudes resembling fusional disruption have not been reported previously with convergence insufficiency. We report 3 patients with severe vergence anomaly in the setting of convergence insufficiency. Read More

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http://dx.doi.org/10.1016/j.jaapos.2020.04.004DOI Listing

Acute acquired concomitant esotropia associated with myopia: is the condition related to any binocular function failure?

Graefes Arch Clin Exp Ophthalmol 2020 Jul 2. Epub 2020 Jul 2.

University Eye Clinic, St. Orsola-Malpighi Teaching Hospital, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, University of Bologna, Bologna, Italy.

Purpose: To evaluate the sensory motor state, accommodation, and accommodative convergence to accommodation ratio (AC/A) in a cohort of non-amblyopic myopes with acquired concomitant esotropia (Bielschowsky esotropia (BE)).

Methods: Refraction, near and far deviation, fusional amplitude (FA), near point of accommodation (NPA), AC/A (gradient method), and stereopsis were measured in a cohort of 26 patients (25 phakic and 1 pseudophakic, age: 14-60 years) with BE, prospectively recruited from January to September 2019 at St. Orsola-Malpighi Hospital, Bologna, Italy. Read More

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http://dx.doi.org/10.1007/s00417-020-04818-1DOI Listing

Sagging Eye Syndrome: A Differential Diagnosis for Diplopia.

Intern Med 2020 Jun 30. Epub 2020 Jun 30.

Department of Neurology, Gifu University Graduate School of Medicine, Japan.

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http://dx.doi.org/10.2169/internalmedicine.4802-20DOI Listing

[Orbital fractures: enigmatic and insidious entities].

Authors:
Paolo Scolozzi

Rev Med Suisse 2020 Jul;16(699):1281-1286

Service de chirurgie maxillo-faciale et de chirurgie buccale, Département de chirurgie, HUG, 1211 Genève 14.

Orbital fractures are frequent and can result in severe complications (visual impairment, diplopia and enophthalmos). Their management is challenging and remains controversial. Whereas immediate surgery is clearly indicated in children with trapdoor fractures associated with annoying diplopia and observational management is indicated in cases with no diplopia, a grey zone of therapy decisions concern a significant portion of cases. Read More

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Anti-N-methyl-D-aspartate-receptor antibody encephalitis combined with syphilis: A case report.

World J Clin Cases 2020 Jun;8(12):2603-2609

Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin Dementia Institute, Department of Neurology, Tianjin Huanhu Hospital, Tianjin 300350, China.

Background: Anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis is a common type of autoimmune encephalitis characterized by complex clinical signs and variable imaging manifestations. The pathogenesis of the disease is unclear. Syphilis is an infectious disease caused by that can invade the nervous and immune systems and cause systemic symptoms. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i12.2603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322422PMC

[Pituitary tumor resection in a patient with SARS-CoV-2 (COVID-19) infection. A case report and suggested airway management guidelines].

Rev Bras Anestesiol 2020 Jun 9. Epub 2020 Jun 9.

University of Mississippi Medical Center, Department of Anesthesiology, Jackson, Mississippi.

The 2020 pandemic caused by the novel coronavirus, COVID-19, had its headquarters in China. It causes Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and presents a broad spectrum of clinical manifestations, ranging from entirely asymptomatic through severe acute respiratory failure and death. Presuming a significant quantity of ventilator-dependent patients, several institutions strategically delayed elective surgeries. Read More

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http://dx.doi.org/10.1016/j.bjan.2020.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282784PMC

Surgery as a safe and effective treatment option for spheno-orbital meningioma: a systematic review and meta-analysis of surgical techniques and outcomes.

Acta Ophthalmol 2020 Jun 29. Epub 2020 Jun 29.

Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands.

Purpose: The effectiveness and safety of surgery for spheno-orbital meningiomas remains subject of debate, as studies often describe different surgical approaches and reconstruction techniques with very heterogeneous outcomes. We aimed to systematically summarize and analyse the literature on spheno-orbital meningiomas regarding presenting symptoms, surgical techniques, outcomes and complications.

Methods: Studies were retrieved from eight databases. Read More

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http://dx.doi.org/10.1111/aos.14517DOI Listing

Adult Pineal Region Atypical Teratoid Rhabdoid Tumor: A Case for Aggressive Surgical and Chemoradiation Management with Comprehensive Literature Review.

World Neurosurg 2020 Jun 26. Epub 2020 Jun 26.

Ochsner Clinic Foundation Department of Neurosurgery, New Orleans, LA; Tulane Medical Center Department of Neurosurgery, New Orleans, LA.

Background: Atypical teratoid rhabdoid tumor (ATRT) is a rare, highly malignant central nervous system neoplasm classified as an embryonal grade IV neoplasm by the World Health Organization. ATRT generally occurs in children younger than 3 years of age with 85 pathologically confirmed cases reported in adults. It is most commonly supratentorial with only 9 confirmed adult cases localized to the pineal region. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.144DOI Listing

Metachronous Bilateral Silent Sinus Syndrome: A Case Report.

Iran J Otorhinolaryngol 2020 May;32(110):175-179

Azienda Unità Sanitaria Locale di Bologna, ENT Department Bologna, Via Altura 3 40139 Bologna, Italy.

Introduction: Bilateral silent sinus syndrome (SSS) is a very rare pathology reported only in few papers in literature. Most of the described cases are simultaneous, and only one had a metachronous presentation. The evolutionary phases of the disease have yet to be well demonstrated and a complete radiological evaluation is needed to demonstrate the pathogenetic mechanisms that cause the disease. Read More

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http://dx.doi.org/10.22038/ijorl.2020.42809.2396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302533PMC

Acute abducens nerve palsy in a patient with the novel coronavirus disease (COVID-19).

J AAPOS 2020 Jun 24. Epub 2020 Jun 24.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. Electronic address:

We present a case of an abducens nerve palsy in a previously healthy young man in the setting of SARS-CoV-2 infection. Magnetic resonance imaging obtained 5 weeks after the onset of diplopia demonstrated an atrophic left lateral rectus muscle, which was hyperintense on T2 weighting, consistent with denervation. Although the mechanism of the nerve palsy remains unclear, it is suspected to be related to his viral illness, because the patient had no preexisting vascular risk factors or evidence of other neurologic disease on neuroimaging. Read More

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http://dx.doi.org/10.1016/j.jaapos.2020.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311910PMC

Transient Neurological Symptoms Preceding Cerebellar Ataxia with Glutamic Acid Decarboxylase Antibodies.

Cerebellum 2020 Jun 26. Epub 2020 Jun 26.

French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, Bron, France.

A prompt diagnosis and treatment of patients with autoimmune cerebellar ataxia (CA) with antibodies against glutamic acid decarboxylase (GAD-Abs) may lead to a better prognosis. Herein, we report prodromal transient neurological symptoms that should raise clinical suspicion of CA with GAD-Abs. We initially identified a 70-year-old man who presented a first acute episode of vertigo, diplopia, and ataxia lasting 2 weeks. Read More

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http://dx.doi.org/10.1007/s12311-020-01159-xDOI Listing

Comparison of post-operative outcomes of graft materials used in reconstruction of blow-out fractures.

Ulus Travma Acil Cerrahi Derg 2020 Jun;26(4):538-544

Department of Ear Nose Throat and Head and Neck Surgery, Yüksek İhtisas University Faculty of Medicine, Liv Hospital Ankara, Ankara-Turkey.

Background: Trauma to the face caused by assault or impact may cause internal orbital fracture. Increased intraorbital pressure without disruption of soft tissue integrity or causing a fracture line in orbital rims or orbital floor fractures described as 'orbital blow-out fracture'. Such fractures have been categorized as 'pure blow-out fractures' in which only the orbital floor is affected, and 'impure blow-out fractures' in which other maxillofacial bones such as zygoma, maxilla and nasoethmoid are also affected. Read More

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http://dx.doi.org/10.14744/tjtes.2020.80552DOI Listing

Balancing orbital volume reduction and redistribution for a tailored surgical treatment in Graves' ophthalmopathy.

Graefes Arch Clin Exp Ophthalmol 2020 Jun 25. Epub 2020 Jun 25.

Department of Endocrinology, Grigore T. Popa University of Medicine and Pharmacy, Universitatii Str, no. 16, 700115, Iasi, Romania.

Aim: The purpose of this study is to share our experience on the use of different orbital decompression techniques, as well as the principles followed for deciding the most case-appropriate procedure that ensured the most favorable outcomes.

Methods: We reviewed the Graves' ophthalmopathy cases operated over the course of 14 years, regarding the presenting signs, the imaging evaluation, the degree of exophthalmos, the type of surgical orbital decompression performed, and the postoperative outcomes.

Results: All 42 patients identified presented with proptosis, with 92. Read More

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http://dx.doi.org/10.1007/s00417-020-04807-4DOI Listing

Pituitary adenoma presenting as acute onset isolated complete third cranial nerve palsy without vision changes.

BMJ Case Rep 2020 Jun 24;13(6). Epub 2020 Jun 24.

Child Sight Institute, Pediatric Ophthalmology, Strabismus and Neuro-ophthalmology, Nimmagadda Prasad Children Eye Care Centre, LV Prasad Eye Institute, GMRV Campus, Visakhapatnam, Andhra Pradesh, India

We report a case of isolated unilateral complete pupil involving third cranial nerve palsy due to pituitary adenoma with parasellar extension into the right cavernous sinus. The patient was referred to us from neurosurgery with sudden onset binocular vertical diplopia with complete ptosis, and mild right-sided headache of 5-day duration. Ocular examination revealed pupil involving third cranial nerve palsy in right eye while rest of the examination including automated perimetry was normal. Read More

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http://dx.doi.org/10.1136/bcr-2019-232490DOI Listing

[Signs, symptoms, and clinical forms of cataract in adults].

J Fr Ophtalmol 2020 Jun 22. Epub 2020 Jun 22.

Service d'ophtalmologie, hôpital d'instruction des Armées Percy, 101, avenue Henri-Barbusse, BP 406, 92141 Clamart cedex, France; École du Val-de-Grâce, 1, place Alphonse-Laveran, 75230 Paris Cedex 05, France.

Cataract is a partial or total opacification of the crystalline lens. In adults, cataract is acquired; the most common form is the age-related cataract. Assessment of the functional impact of a cataract is clinical. Read More

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http://dx.doi.org/10.1016/j.jfo.2019.11.009DOI Listing

Factors associated with long-term risk of recurrence after percutaneous radiofrequency thermocoagulation of the gasserian ganglion for patients with trigeminal neuralgia involving the ophthalmic division: A retrospective study.

Pain Pract 2020 Jun 25. Epub 2020 Jun 25.

Department of Pain Management, Xuanwu Hospital of Capital Medical University, Beijing, China, 100053.

Objective: To evaluate risk factors associated with recurrence after radiofrequency thermocoagulation (RFT) of gasserian ganglion among patients with ophthalmic trigeminal neuralgia (TN) and prognostic factors in terms of recurrence-free survival (RFS) during a long-term follow-up.

Methods: From January 2005 to December 2017, 300 patients with ophthalmic TN underwent RFT. A retrospective analysis of 14-year outcomes was performed. Read More

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http://dx.doi.org/10.1111/papr.12930DOI Listing

Diplopia and ocular pain due to orbital myositis.

Clin Rheumatol 2020 Jun 23. Epub 2020 Jun 23.

Department of Rheumatology, Hospital Universitario "Dr. Jose Eleuterio Gonzalez", Monterrey, Nuevo Leon, Mexico.

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http://dx.doi.org/10.1007/s10067-020-05147-8DOI Listing

Immunotherapy-related skeletal muscle weakness in cancer patients: a case series.

Ann Palliat Med 2020 Jun 21. Epub 2020 Jun 21.

Department of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Immunotherapy has become a lifeline in cancer treatment. However, increasingly reports of programmed death-1 (PD-1) inhibitors have been linked to autoimmune disorders. We highlight two unique cases that presented with skeletal weakness and resulted in fatalities after developing de novo myasthenia gravis and myositis associated to immunotherapy treatment. Read More

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http://dx.doi.org/10.21037/apm-20-454DOI Listing

A case of silent sinus syndrome following a history of multiple facial traumas.

Authors:
Megan C Mills

Clin Exp Optom 2020 Jun 22. Epub 2020 Jun 22.

School of Optometry, University of Alabama at Birmingham, Birmingham, Alabama, USA.

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http://dx.doi.org/10.1111/cxo.13113DOI Listing

Breast Cancer Metastases to the Paranasal Sinuses Mimicking Inflammatory Sinus Disease.

J Craniofac Surg 2020 Jul-Aug;31(5):e525-e527

Department of Otolaryngology, Head and Neck Surgery, Tufts Medical Center, Boston, MA.

Introduction: Breast cancer is one of the most common cancers in women. Metastatic disease is a leading cause of morbidity and mortality. It frequently metastasizes to bone, lungs, regional lymph nodes, liver and brain. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006708DOI Listing

Clinical efficacy of the partial rectus muscle transportation procedure for paralytic strabismus.

Int J Ophthalmol 2020 18;13(6):978-984. Epub 2020 Jun 18.

Eye Center of Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.

Aim: To analyze the clinical efficacy of the partial rectus muscle transportation (PRT) procedure for paralytic strabismus due to single rectus muscle palsy.

Methods: In total, 28 patients (31 eyes) who underwent the PRT procedure for paralytic strabismus due to single rectus muscle palsy were retrospectively examined. The following data were collected pre- and postoperatively: angle of deviation in the primary position, presence of diplopia in the primary position, presence of compensatory head posture, and motility of the affected eye. Read More

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http://dx.doi.org/10.18240/ijo.2020.06.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270266PMC

Immune Checkpoint Inhibitor-Mediated Myasthenia Gravis.

J Emerg Med 2020 Jun 18. Epub 2020 Jun 18.

Department of Acute Medicine and Critical Care, The Christie, NHS Foundation Trust, Manchester, United Kingdom.

Background: Immune checkpoint inhibitors (ICIs) have a wide range of toxicities affecting potentially any organ system stemming from increased activity within the T-cell lineage similar to that observed in autoimmunity.

Case Report: A 57-year-old man with metastatic papillary renal cell carcinoma treatment with combination ICI therapy presented with a history of rapidly progressive diplopia. Neurological examination revealed bilateral fatigable ptosis and asymmetrical ophthalmoplegia. Read More

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http://dx.doi.org/10.1016/j.jemermed.2020.05.004DOI Listing
June 2020
1.175 Impact Factor

The Impact of Thyroid Diseases on the Working Life of Patients: A Systematic Review.

Int J Environ Res Public Health 2020 Jun 16;17(12). Epub 2020 Jun 16.

Section of Occupational Medicine, Department of Public Health, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.

Thyroid diseases are characterized by a wide range of physical and mental symptoms that can affect biological function, emotional and social life of patients. However, their impact on work functioning is not yet fully understood. Therefore, this review aims to address the way in which thyroid diseases can affect occupational outcomes, i. Read More

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http://dx.doi.org/10.3390/ijerph17124295DOI Listing

Successful Intravascular Treatment of an Intraosseous Arteriovenous Fistula in Fibrous Dysplasia.

Calcif Tissue Int 2020 Aug 17;107(2):195-200. Epub 2020 Jun 17.

Skeletal Diseases and Mineral Homeostasis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Building 30, Room 207, Bethesda, MD, 20892-4320, USA.

Fibrous dysplasia (FD) is a benign bone disease characterized by expansile lesions that typically stabilize with age. Rarely, FD can undergo malignant transformation, presenting with atypical, rapid growth and destruction of adjacent bone. Other potential causes of rapid FD expansion include secondary lesions, such as aneurysmal bone cysts. Read More

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http://dx.doi.org/10.1007/s00223-020-00712-4DOI Listing

Pituitary apoplexy induced by gonadotropin-releasing hormone agonist administration: a rare complication of prostate cancer treatment.

Endocrinol Diabetes Metab Case Rep 2020 Jun 4;2020. Epub 2020 Jun 4.

Department of Endocrinology, Hospital de Braga, Braga, Portugal.

Summary: Gonadotropin-releasing hormone (GnRH) agonists, currently used in the treatment of advanced prostate cancer, have been described as a rare cause of pituitary apoplexy, a potentially life-threatening clinical condition. We report the case of a 69-year-old man with a known pituitary macroadenoma who was diagnosed with prostate cancer and started treatment with GnRH agonist leuprorelin (other hormones were not tested before treatment). Few minutes after drug administration, the patient presented with acute-onset severe headache, followed by left eye ptosis, diplopia and vomiting. Read More

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http://dx.doi.org/10.1530/EDM-20-0018DOI Listing

Transvenous embolization of bilateral indirect carotid-cavernous fistulas via a unilateral transorbital approach.

Orbit 2020 Jun 19:1-6. Epub 2020 Jun 19.

Department of Neurological Surgery, Tulane University , New Orleans, USA.

A 73-year-old man with a complex ophthalmologic history presented with several weeks of worsening diplopia, visual acuity, and proptosis bilaterally. Cerebral angiography demonstrated bilateral indirect Barrow type B carotid-cavernous fistulas (CCFs). Transarterial embolization was not attempted due to small arterial diameter and risk of stroke. Read More

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http://dx.doi.org/10.1080/01676830.2020.1779753DOI Listing

Rhino-orbital-cerebral mucormycosis (ROCM) and associated cerebritis treated with adjuvant retrobulbar amphotericin B.

Am J Ophthalmol Case Rep 2020 Sep 6;19:100771. Epub 2020 Jun 6.

California Pacific Medical Center, San Francisco, CA, United States.

Purpose: We report a case of rhino-orbital-cerebral mucormycosis (ROCM) with focal anterior cerebritis treated favorably with retrobulbar amphotericin B and systemic antifungals.

Observations: A 55-year-old diabetic male presented to the emergency department with left sided proptosis, left temple headache, maxillary sinus pain, and diplopia of 3 days duration. Biopsy results from the left middle turbinate, ethmoid, and maxillary sinus revealed broad and irregular non-septate hyphae consistent with mucormycosis. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287239PMC
September 2020

Primary Sinonasal Lymphoma: A Rare Cause of Cranial Neuropathies.

Cureus 2020 May 15;12(5):e8135. Epub 2020 May 15.

Medicine/Hematology, State University of New York (SUNY) Upstate Medical University, Syracuse, USA.

Primary sinonasal lymphomas are a rare type of non-Hodgkin lymphoma (NHL) with an overall incidence of about 1% of all head and neck cancers. Diffuse large B-cell lymphoma (DLBCL) is the most common type of NHL and it most commonly occurs in elderly men. The diagnosis of such a lymphoma is difficult because of its varied presentation, which usually occurs late after a significant mass effect has taken place. Read More

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http://dx.doi.org/10.7759/cureus.8135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294899PMC

Management of Recurrent Pterygium with Severe Symblepharon Using Mitomycin C, Double Amniotic Membrane Transplantation, Cryopreserved Limbal Allograft, and a Conjunctival Flap.

Int Med Case Rep J 2020 21;13:201-209. Epub 2020 May 21.

Department of Ophthalmology, Kurume University School of Medicine, Fukuoka, Japan.

Purpose: The aim of this study was to evaluate the clinical outcomes of management of recurrent pterygium with severe symblepharon using mitomycin C, double amniotic membrane transplantation, cryopreserved limbal allograft, and a conjunctival flap.

Patients And Methods: This retrospective case series included 10 eyes of 10 patients with recurrent pterygium with severe symblepharon. Eight patients have diplopia in primary gaze. Read More

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http://dx.doi.org/10.2147/IMCRJ.S245256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247734PMC

The good toxin: 10 years of experience with botulinum toxin A in the treatment of benign essential blepharospasm.

Eur J Ophthalmol 2020 May 26:1120672120925630. Epub 2020 May 26.

Department of Ophthalmology, Tung Wah Eastern Hospital, Causeway Bay, Hong Kong.

Purpose: To describe the efficacy and safety of botulinum toxin A (Botox) in patients with benign essential blepharospasm.

Methods: Retrospective review of operation, injection, and medical records.

Results: Information of 29 patients (nine males) was reviewed, and the average age of benign essential blepharospasm onset was 59. Read More

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http://dx.doi.org/10.1177/1120672120925630DOI Listing

Optical Coherence Tomography Findings Following Orbital Fractures.

J Craniofac Surg 2020 Jul-Aug;31(5):e522-e525

Division of Maxillofacial Surgery, University Hospital "Maggiore della Carità," University of Eastern Piedmont, Novara, Italy.

Introduction: A closed globe trauma is often associated with orbital wall fractures. In addition to diplopia, further eye disturbances can be observed. The aim of this preliminary prospective study was to investigate the optical coherence tomography (OCT) findings in patients that presented with orbital fractures in association with diplopia but without decreased visual acuity or further ocular symptoms. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006695DOI Listing

Neuroanatomical basis of Wallenberg syndrome.

Cir Cir 2020 ;88(3):376-382

Facultad de Medicina, Universidad Autónoma de México (UNAM), Ciudad de México, México.

Wallenberg syndrome, or lateral medullar syndrome, is the clinical presentation of the infarct in the territory of posterior inferior cerebellar artery. Its signs and symptoms include vertigo, nystagmus, diplopia, ipsilateral Horner syndrome, facial ruddiness and dry skin, dysphonia, dysphagia, dysarthria, ipsilateral loss of gag reflex, ipsilateral ataxia, ipsilateral impaired taste, ipsilateral facial pain and paresthesia, decreased ipsilateral blink reflex, contralateral hypoalgesia and thermoanaesthesia in the trunk and limbs; and ipsilateral facial hypoalgesia and thermoanaesthesia. Neuroanatomical knowledge is essential to its comprehension, study and diagnosis, because the classic neurological manifestations are easy to explain and understand if function and localization of affected anatomical structures are known as if the posterior cerebral circulation is. Read More

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http://dx.doi.org/10.24875/CIRU.19000801DOI Listing
January 2020

Intravenous Glucocorticoid Treatment for Korean Graves' Ophthalmopathy Patients.

J Korean Med Sci 2020 Jun 15;35(23):e177. Epub 2020 Jun 15.

Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea.

Background: High-dose intravenous steroids are the first-line treatment for patients with moderate-to-severe and active Graves' ophthalmopathy (GO). We aimed to investigate the response rate of methylprednisolone (MPD) treatment among Korean patients with active moderate-to-severe GO and to identify predictive factors of treatment response.

Methods: This is a retrospective observational study. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295605PMC

[A case of sporadic late-onset nemaline myopathy associated with myasthenia gravis positive for anti-titin antibody and anti-Kv1.4 antibody].

Rinsho Shinkeigaku 2020 Jun 13. Epub 2020 Jun 13.

Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University.

A 66-year-old woman who had myasthenia gravis (MG) admitted for type II respiratory failure and right heart failure. Although she had neither ptosis, eye movement disorder, nor diplopia, she had orbital muscles weakness, reduction of gag reflex, dysarthria, dysphagia, and mild proximal muscle weakness. Blood tests showed anti-striated muscle antibodies (anti-titin antibody and anti-Kv1. Read More

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http://dx.doi.org/10.5692/clinicalneurol.60.cn-001427DOI Listing

Isolated post SARS-CoV-2 diplopia.

J Neurol 2020 Jun 12. Epub 2020 Jun 12.

Service de Neurologie, APHP, Hôpital Avicenne, Hôpitaux Universitaires de Paris-Seine Saint Denis, Sorbonne Paris Nord, Bobigny, France.

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http://dx.doi.org/10.1007/s00415-020-09987-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292242PMC