50,226 results match your criteria Dilated Pore of Winer


Renal Functions and Prognosis Stratification in Chronic Heart Failure Patients and the Importance of Neutrophil Gelatinase-Associated Lipocalin.

Kidney Blood Press Res 2018 Dec 7;43(6):1865-1877. Epub 2018 Dec 7.

Department of Internal Cardiology Medicine, Faculty Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Background/aims: The rate of incidence and prevalence of acute kidney injury is increasing due to an increased number of patients with heart failure. Therefore it is very pertinent to early detect the level of renal injuries and to make necessary heart failure predictions. Thus the aim of this study is to determine renal functions and prognosis stratification in chronic heart failure patients and importance of Neutrophil Gelatinase-Associated Lipocalin (NGAL), an early diagnostic marker of acute kidney injury, as well as stratification of cardiovascular risk in heart failure patients. Read More

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December 2018

Prenatal diagnosis of antenatal midgut volvulus: Specific ultrasound features.

Prenat Diagn 2018 Dec 9. Epub 2018 Dec 9.

Department of Pediatric Imaging, CHU Montpellier, Montpellier, France.

Objective: To assess specific, direct, and indirect prenatal ultrasound features in cases of fetal midgut volvulus.

Methods: Retrospective case series of neonatal volvulus, based on postnatal and prenatal imaging findings that occurred from 2006-2017. Prenatal and postnatal signs including the specific "whirlpool sign" were computed. Read More

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December 2018

Melatonin release by exocytosis in the rat parotid gland.

J Anat 2018 Dec 10. Epub 2018 Dec 10.

Department of Biomedical Sciences, Division of Cytomorphology, University of Cagliari, Cagliari, Italy.

Several beneficial effects on oral health are ascribed to melatonin. Due to its lipophilic nature, non-protein-bound circulating melatonin is usually thought to enter the saliva by passive diffusion through salivary acinar gland cells. Recently, however, using transmission electron microscopy (TEM), melatonin was found in acinar secretory granules of human salivary glands. Read More

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December 2018

Evaluation of a high-sensitivity cardiac troponin I assay compared to a first-generation cardiac troponin I assay in Doberman Pinschers with and without dilated cardiomyopathy.

J Vet Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Clinic of Small Animal Medicine, LMU University, Munich, Germany.

Background: Echocardiography and 24-hour ECG are the gold standard tests to diagnose dilated cardiomyopathy (DCM) in Doberman Pinschers (DP), but myocardial damage might be detected earlier using a high-sensitivity cardiac troponin I (hs-cTnI) assay.

Objective: To evaluate and compare an hs-cTnI assay (Advia Centaur TnI-Ultra assay) with a conventional cTnI assay in DP with different stages of DCM and in healthy DP.

Animals: Three hundred forty-five examinations from 162 DP with and 179 DP without DCM. Read More

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December 2018

Effects of formaldehyde on VEGF, MMP2, and Osteonectin levels in periodontal membrane and alveolar bone in the rats.

Folia Morphol (Warsz) 2018 Dec 11. Epub 2018 Dec 11.

Department of Histology and Embryology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.

Background: The objective of this study was to investigate if long term formaldehyde inhalation may effect periodontal membrane and alveolar bone loss leading to periodontitis. the negative effects of formaldehyde was described using vascular endothelial growth factor (VEGF), matrix metallopeptidase 2 (MMP2) and Osteonectin antibodies involved in the extracellular matrix and angiogenetic development.

Materials And Methods: Thirty adult Wistar albino rats were used in this study. Read More

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December 2018

Identification and Functional Characterization of an ISL1 Mutation Predisposing to Dilated Cardiomyopathy.

J Cardiovasc Transl Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiology, Cardiovascular Research Laboratory, and Center for Complex Arrhythmias of Minhang District, The Fifth People's Hospital of Shanghai, Fudan University, No. 801 Heqing Road, Shanghai, 200240, China.

Dilated cardiomyopathy (DCM) is the most prevalent cause of non-ischemic cardiac failure and the commonest indication for cardiac transplantation. Compelling evidence highlights the pivotal roles of genetic defects in the occurrence of DCM. Nevertheless, the genetic determinants underpinning DCM remain largely obscure. Read More

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December 2018

Heart involvement in patients with myotonic dystrophy type 2.

Acta Neurol Belg 2018 Dec 7. Epub 2018 Dec 7.

Neurology Clinic, Clinical Centre of Serbia, School of Medicine, University of Belgrade, 6, Dr Subotica Street, Belgrade, 11000, Serbia.

Myotonic dystrophy type 2 (DM2) is a slowly progressive, autosomal-dominant disease. This is a multisystemic disorder that affects the heart, which is one of the main causes of morbidity and mortality in DM2. The aim of the study was to define cardiac impairments in patients with DM2 and its association with sociodemographic and clinical features of patients. Read More

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December 2018

A case of huge lymphatic and venous malformations of the mediastinum.

Respir Med Case Rep 2019 22;26:53-55. Epub 2018 Nov 22.

Department of Respiratory Medicine, Iizuka Hospital, 3-83 Yoshiomachi, Iizuka, Fukuoka 820-0018, Japan.

We herein report a case of huge lymphatic and venous malformations of the mediastinum (LVM). A 19-year-old man presented for evaluation of a mediastinal mass. On chest computed tomography, the mass demonstrated contrast enhancement and showed dilated veins draining into the superior and inferior vena cava, with multiple scattered calcifications. Read More

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November 2018

Short-term Optic Disc Cupping Reversal in a Patient with Mild Juvenile Open-angle Glaucoma Due to Early Idiopathic Intracranial Hypertension.

J Glaucoma 2018 Dec 10. Epub 2018 Dec 10.

Vanderbilt Eye Institute, Vanderbilt University Medical Center, 2311 Pierce Avenue, Nashville, TN, 37232.

Purpose: The purpose of this study is to report a case of optic disc cupping reversal in an adult without significant intraocular pressure lowering treatment.

Patient: A 20-year-old female with a history of mild juvenile open-angle glaucoma who developed subjective blurred vision and a decrease in cupping of her optic discs.

Results: Dilated examination demonstrated decreased cup-to-disc ratios in both eyes with slight blurring of the disc margin in the right eye. Read More

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December 2018

Incarcerated paraesophageal hernia complicated by pancreatic damage and unusual comorbidity: Two retrospective case series.

Int J Surg Case Rep 2018 Nov 30;54:75-78. Epub 2018 Nov 30.

Department of Pediatric and Gastrointestinal Surgery, Oslo University Hospital, Ullevål, P.O. box 4950, 0424 Oslo, Norway. Electronic address:

Introduction: About 1% of paraesophageal hernias (PEH) require emergency surgery due to obstruction or gangrene. We present two complicated cases of incarcerated PEH. Presentation of cases: A patient aged 18 with trisomy 21 was admitted after four days of vomiting and epigastric pain. Read More

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November 2018

Coronary Sinus Stenosis with Right Coronary Artery to Coronary Sinus Fistula.

Ann Thorac Surg 2018 Dec 7. Epub 2018 Dec 7.

Division of Cardiology, Children's Hospital of Michigan, Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan. Electronic address:

Coronary artery fistula is a rare congenital cardiac anomaly. We report a 34-year-old female who presented with a recurrent large pericardial effusion during pregnancy. She was found to have a right coronary artery to coronary sinus fistula. Read More

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December 2018

Cerclage for women with twin pregnancies: a systematic review and meta-analysis.

Am J Obstet Gynecol 2018 Dec 7. Epub 2018 Dec 7.

Department of Obstetrics and Gynecology, The Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China. Electronic address:

Objective: To estimate whether cerclage could extend the prolongation of pregnancy, reduce the risk of preterm birth (PTB) and improve perinatal outcomes in women with twin pregnancies.

Study Design: The following databases including Medline, EMBASE, Scopus, ClinicalTrials.gov, Web of Science, and Cochrane Library were searched for all published studies that compared cerclage placement with expectant management in twin pregnancies from inception to July 2018. Read More

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December 2018

Genetic and non-genetic determinants of clinical phenotypes in cardiomyopathy.

Authors:
Seitaro Nomura

J Cardiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address:

Cardiomyopathy, a leading cause of death worldwide, is etiologically and phenotypically heterogeneous and is caused by a combination of genetic and non-genetic factors. Major genomic determinants of dilated cardiomyopathy (DCM) are titin truncating mutations and lamin A/C mutations. Patients with these two genotypes show critically different phenotypes, including penetrance, coexistence with a conduction system abnormality, cardiac prognosis, and treatment response. Read More

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December 2018
1 Read

The Skin Bridge Is More Important as an Additional Venous Draining Route in a Perforator-Plus Flap.

J Surg Res 2019 Feb 27;234:40-48. Epub 2018 Sep 27.

Fujian Key Laboratory of Brain Aging and Neurodegenerative Diseases, Department of Human Anatomy and Embryology, Fujian Medical University, Fuzhou, Fujian, China. Electronic address:

Background: The skin bridge in the perforator-plus flap is considered as an additional source for arterial input and venous drainage apart from the perforator. However, its exact role requires further elucidation.

Materials And Methods: Forty rats that underwent flap elevation with a size of 9 × 3 cm on the dorsum were evenly divided into a perforators-intact group with an intact vascular pedicle, an artery-deficient group with the artery ligated, a vein-deficient group with the vein ligated, and a perforators-deficient group with both vessels ligated. Read More

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February 2019

Cardiovascular images: vascular hamartoma of the mitral valve in a horse.

J Vet Cardiol 2018 Dec 18;20(6):399-404. Epub 2018 Oct 18.

Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA. Electronic address:

An 8-month-old Hanoverian gelding was presented with a history of cardiac murmurs that were not apparent as a foal nor reported at the time of castration. Major echocardiographic findings included mitral valvular thickening, functional stenosis, and mitral regurgitation of sufficient severity to cause diastolic and systolic cardiac murmurs, left-sided volume overload, and pulmonary hypertension. Due to the hemodynamic severity of the lesion and poor prognosis for future performance and longevity, euthanasia was elected. Read More

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December 2018

BK virus nephropathy and multiorgan involvement in a child with heart transplantation
.

Clin Nephrol 2018 Dec 11. Epub 2018 Dec 11.

BK virus is a known cause of renal failure in kidney transplant recipients, but there is little data regarding its effect on native kidneys in heart transplant patients. Here, we describe the case of a child who underwent heart transplantation and was later diagnosed with BK virus with multiorgan involvement. This patient was diagnosed with dilated cardiomyopathy at 4 months of age and underwent heart transplantation at the age of 5 years. Read More

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December 2018

Novel Therapeutic Strategy for Pharyngoesophageal Stricture following Total Laryngectomy.

Otolaryngol Head Neck Surg 2018 Dec 11:194599818815164. Epub 2018 Dec 11.

1 Department of Gastroenterology and Hepatology, St George Hospital, Sydney, Australia.

Current therapeutic strategies for pharyngoesophageal stricture, while effective in the short term, are protracted and costly in the longer term. Conceptually, if a stricture can be dilated with minimal tissue injuries, the rate of fibrosis and the resultant stricture recurrence could be reduced. We evaluated a prototype computer-controlled syringe pump device programmed to distend a commercially available balloon dilator at variable rate, asserting incremental lumen distension pressures tailored to the resistive force encountered within the stricture. Read More

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December 2018

Linking Clinical Parameters and Genotype in Dilated Cardiomyopathy.

Authors:
Jared M Churko

Circ Heart Fail 2018 Nov;11(11):e005459

Department of Cellular and Molecular Medicine, University of Arizona, Tucson.

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November 2018

Early myocardial changes induced by doxorubicin in the non-failing dilated ventricle.

Am J Physiol Heart Circ Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Physiology, Faculty of Medicine, University of Porto, Portugal.

Several studies demonstrate that administration of doxorubicin results in cardiotoxicity, which eventually progresses to dilated cardiomyopathy. The present work aims to evaluate the early myocardial changes of doxorubicin-induced cardiotoxicity. Male New Zealand white rabbits were injected intravenously, twice weekly for 8 weeks with doxorubicin (DOXO-HF) or with an equivolumetric dose of saline (CONTROL). Read More

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December 2018

Extracorporeal membrane oxygenation as a bridge for heart transplantation by Chagas cardiomyopathy

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):429-433. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Cardiología, Servicio de Anestesiología. Ciudad de México, México

Background: Extracorporeal membrane oxygenation is a technique indicated in cases of severe respiratory failure or in situations where pump failure or heart failure is refractory to conventional medical treatment. Our goal was to describe the results of a patient with chronic Chagas dilated cardiomyopathy treated with extracorporeal membrane oxygenation as bridging therapy for heart transplantation.

Case Report: A 62-year old male with a history of Chagas disease and severe ventricular failure who underwent veno-arterial extracorporeal membrane oxygenation as bridging therapy for heart transplantation, with good clinical evolution. Read More

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November 2018
2 Reads

Natriuretic Peptide Processing in Patients with and Without Left Ventricular Dysfunction.

Int Heart J 2018 Dec 5. Epub 2018 Dec 5.

Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis.

This study aimed to examine the relationship between corin expression and circulating brain natriuretic peptide in patients with left ventricular (LV) dysfunction.Circulating levels of B-type natriuretic peptide (BNP) can be an indicator of LV dysfunction. The 32-amino-acid BNP is cleaved by corin, a cardiac serine protease, from its108-amino-acid pro-brain natriuretic peptide (proBNP) precursor. Read More

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December 2018

Converter domain mutations in myosin alter structural kinetics and motor function.

J Biol Chem 2018 Dec 5. Epub 2018 Dec 5.

Cellular and Molecular Physiology, Penn State University College of Medicine, United States.

Myosins are molecular motors that use a conserved ATPase cycle to generate force. We investigated two mutations in the converter domain of myosin V (R712G and F750L) to examine how altering specific structural transitions in the motor ATPase cycle can impair myosin mechanochemistry. The corresponding mutations in the human beta-cardiac myosin gene are associated with hypertrophic and dilated cardiomyopathy, respectively. Read More

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December 2018

CAP2 mutation leads to impaired actin dynamics and associates with supraventricular tachycardia and dilated cardiomyopathy.

J Med Genet 2018 Dec 5. Epub 2018 Dec 5.

The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel.

Background: Dilated cardiomyopathy (DCM) is a primary myocardial disease leading to contractile dysfunction, progressive heart failure and excessive risk of sudden cardiac death. Around half of DCM cases are idiopathic, and genetic factors seem to play an important role.

Aim: We investigated a possible genetic cause of DCM in two consanguineous children from a Bedouin family. Read More

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December 2018

Electrocardiographic and echocardiographic features in patients with major arterial vascular disease assigned to surgical revascularization.

Acta Cardiol 2018 Dec 3:1-7. Epub 2018 Dec 3.

a Dipartimento di Medicina Interna e Scienze Biomediche, Sezione di Cardiologia , Università degli Studi di Parma , Parma , Italy.

Background: We aimed to depict the electrocardiographic and echocardiographic aspects in patients before elective major vascular surgery.

Methods: We evaluated through standard 12 lead electrocardiography and transthoracic echocardiography 469 patients with asymptomatic large abdominal aortic aneurysm (AAA), 334 with critical carotid stenosis (CAS), and 238 with advanced peripheral artery disease (PAD) before surgical revascularization.

Results: Patients with AAA were predominantly males (p < . Read More

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December 2018

A novel EMD mutation in a Chinese family with initial diagnosis of conduction cardiomyopathy.

Brain Behav 2018 Dec 3:e01167. Epub 2018 Dec 3.

Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, China.

Introduction: Emery-Dreifuss muscular dystrophy (EDMD) is a hereditary myopathy characterized as triad of muscular dystrophy, joint contractures, and conduction cardiomyopathy. In this study, we diagnosed a X-linked recessive EDMD patient with severe conduction cardiomyopathy while noteless muscular and joint disorders.

Methods: A Chinese cardiomyopathy family spanning four generations was enrolled in the study. Read More

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December 2018
1 Read

Deciphering the SUMO code in the kidney.

J Cell Mol Med 2018 Dec 1. Epub 2018 Dec 1.

Department of Nephrology, The First Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi, China.

SUMOylation of proteins is an important regulatory element in modulating protein function and has been implicated in the pathogenesis of numerous human diseases such as cancers, neurodegenerative diseases, brain injuries, diabetes, and familial dilated cardiomyopathy. Growing evidence has pointed to a significant role of SUMO in kidney diseases such as DN, RCC, nephritis, AKI, hypertonic stress and nephrolithiasis. Recently, emerging studies in podocytes demonstrated that SUMO might have a protective role against podocyte apoptosis. Read More

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December 2018

Antibiotics for urethral catheterization in children undergoing cystography: retrospective evaluation of a single-center cohort of pediatric non-toilet-trained patients.

Eur J Pediatr 2018 Dec 1. Epub 2018 Dec 1.

Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 80138, Naples, Italy.

Antibiotics are often used to prevent post-catheterization urinary tract infections (UTIs) in patients undergoing cystography. However, there is no universally accepted protocol and the literature data are conflicting. We aimed to determine prevalence and risk factors of post-cystography UTIs in non-toilet-trained children. Read More

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December 2018

Adrenocortical Carcinoma Presenting as Reversible Dilated Cardiomyopathy.

Heart Views 2018 Apr-Jun;19(2):71-73

Department of General Medicine, MES Medical College, Malappuram, Kerala, India.

We present a 32-year-old woman with no morbidities who was admitted with a dilated cardiomyopathy and cardiac failure due to adrenocortical carcinoma (ACC) which improved completely with surgical resection. Awareness regarding such rare presentations can avoid undue delay in diagnosis and management. Read More

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December 2018

Bilateral identical intervals between phacoemulsification procedures performed 23 years before retinal detachment.

Oman J Ophthalmol 2018 Sep-Dec;11(3):274-276

2nd Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, "Papageorgiou" General Hospital, 564 03 Thessaloniki, Macedonia, Greece.

We aim to present a case of bilateral rhegmatogenous retinal detachment (RRD) after successful phacoemulsification procedures performed 23 years before RRD onset and surgical management. A 57-year-old female presented with blurred vision due to floaters in the left eye. The patient was followed up with dilated fundus examination. Read More

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December 2018
1 Read

Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation.

Nat Commun 2018 11 30;9(1):5107. Epub 2018 Nov 30.

Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 16419, Korea.

Dysregulation of Ca/calmodulin-dependent protein kinase (CaMK)II is closely linked with myocardial hypertrophy and heart failure. However, the mechanisms that regulate CaMKII activity are incompletely understood. Here we show that protein arginine methyltransferase 1 (PRMT1) is essential for preventing cardiac CaMKII hyperactivation. Read More

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November 2018

[Pulmonary hypertension as presentation in multiple myeloma].

Medicina (B Aires) 2018 ;78(6):443-446

Centro de Medicina Respiratoria, Hospital Británico de Buenos Aires, Argentina.

Multiple myeloma is a hematologic disease, which accounts for 15% of hematologic malignancies. The average age of onset is between 65-70 years and is very rare in young patients, as 2% are under 40 years old. We present a case of 36-year-old women with history of 20 pack years (p/y) smoking, who complaints of dyspnea associated with signs of right cardiac overload, anemia, proteinuria, elevated acute phase reactants and spirometry pattern suggestive of moderately-severe restriction and severe drop in diffusing capacity for carbon monoxide (DLCO). Read More

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January 2018

Recombinant human glucagon-like peptide-1 protects against chronic intermittent hypoxia by improving myocardial energy metabolism and mitochondrial biogenesis.

Mol Cell Endocrinol 2018 Nov 29. Epub 2018 Nov 29.

Department of Endocrinology, The Third Affiliated Hospital of Soochow University, Changzhou City, 213003, China. Electronic address:

Background And Aims: Obstructive sleep apnea syndrome is a chronic disease associated with intermittent hypoxia (IH) and is an important risk factor for cardiovascular disease. Glucagon-like peptide (GLP-1) is a naturally occurring incretin used as a promising therapeutic agent in the treatment of acute myocardial infarction, dilated cardiomyopathy, and advanced heart failure. However, whether GLP-1 can protect against IH-induced cardiac injury is still unclear. Read More

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November 2018

Transurethral ablation of a prostatic utricle cyst with the use of a holmium laser.

Fertil Steril 2018 Dec;110(7):1410-1411

Department of Urology, University of Miami, Miami, Florida. Electronic address:

Objective: To demonstrate a safe and effective approach to the treatment of obstructing midline prostate utricle cyst with the use of a holmium laser.

Design: Video presentation.

Setting: University hospital. Read More

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December 2018

Effects of pedicle torsion on dynamic perforasome survival in a multiterritory perforator flap model: An experimental study.

J Plast Reconstr Aesthet Surg 2018 Nov 2. Epub 2018 Nov 2.

Department of Hand and Plastic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 West Xue Yuan Road, Lu Cheng District, Wenzhou 325000 China. Electronic address:

Background: Necrosis of propeller flaps is a problem in clinical practice. This study was performed to investigate the effects of pedicle torsion on dynamic perforasome survival using a multiterritory perforator flap model in rats.

Methods: Intercostal artery perforator flaps (IC flaps) containing two adjacent dynamic perforasomes were applied to both sides of the dorsum in 15 rats. Read More

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November 2018

The administration of high-mobility group box 1 fragment prevents deterioration of cardiac performance by enhancement of bone marrow mesenchymal stem cell homing in the delta-sarcoglycan-deficient hamster.

PLoS One 2018 5;13(12):e0202838. Epub 2018 Dec 5.

Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Objectives: We hypothesized that systemic administration of high-mobility group box 1 fragment attenuates the progression of myocardial fibrosis and cardiac dysfunction in a hamster model of dilated cardiomyopathy by recruiting bone marrow mesenchymal stem cells thus causing enhancement of a self-regeneration system.

Methods: Twenty-week-old J2N-k hamsters, which are δ-sarcoglycan-deficient, were treated with systemic injection of high-mobility group box 1 fragment (HMGB1, n = 15) or phosphate buffered saline (control, n = 11). Echocardiography for left ventricular function, cardiac histology, and molecular biology were analyzed. Read More

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December 2018
3 Reads

Prospective Comparison of Bleeding Complications Between Right and Left Approaches in Percutaneous Biliary Drainage.

Surg Laparosc Endosc Percutan Tech 2018 Dec 3. Epub 2018 Dec 3.

Department of Surgery, University of Buenos Aires.

Purpose: The present study aimed to determine whether the percentage of bleeding complications differs between the right and the left approaches in percutaneous biliary drainage (PBD) in adult patients.

Materials And Methods: This was a prospective, descriptive, nonrandomized comparative and longitudinal study. We included adult patients over 18 years of age who underwent a PBD. Read More

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December 2018

Carotid Artery Stenting Without Embolic Protection Device: A Single-Center Experience.

J Endovasc Ther 2018 Dec 4:1526602818816656. Epub 2018 Dec 4.

1 Department of Vascular and Endovascular Surgery, IRCCS Sacro Cuore Don Calabria, Negrar, Italy.

Purpose: To evaluate the safety and efficacy of carotid artery stenting (CAS) performed without an embolic protection device (EPD) in a selected group of asymptomatic patients with primary internal carotid artery (ICA) stenosis or restenosis after carotid endarterectomy (CEA).

Materials And Methods: Between May 2015 and May 2018, 77 patients (mean age 77 years; 60 men) underwent CAS without any embolic protection device. Forty-seven (61%) patients had primary ICA stenosis and were excluded from CEA because of high surgical risk; the other 30 (39%) patients had post-CEA restenosis (n=26) or a distal ICA flap after eversion CEA (n=4). Read More

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December 2018

Hemodynamic and neuronal responses to cocaine differ in awake versus anesthetized animals: Optical brain imaging study.

Neuroimage 2018 Dec 1. Epub 2018 Dec 1.

Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, 11794, USA. Electronic address:

Cocaine is a highly addictive drug with complex pharmacological effects. Most preclinical imaging studies investigating the effects of cocaine in the brain have been performed under anesthesia, which confounds findings. To tackle this problem, we used optical imaging to compare the effects of cocaine in the awake versus the anesthetized state. Read More

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December 2018
1 Read

Two Cases of White Globe Appearance in Autoimmune Atrophic Gastritis.

Case Rep Gastrointest Med 2018 30;2018:7091520. Epub 2018 Oct 30.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.

In this report, we described two patients with white globe appearance in autoimmune atrophic gastritis. Endoscopy revealed multiple white substances in the stomach in both cases. Biopsied specimens from the lesions contained dilated glands and showed a decrease in parietal cells. Read More

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October 2018
2 Reads

Prenatal MR imaging features of Caroli syndrome in association with autosomal recessive polycystic kidney disease.

Radiol Case Rep 2019 Feb 26;14(2):265-268. Epub 2018 Nov 26.

Department of Radiology, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 10104, USA.

Caroli syndrome, which is characterized by saccular and fusiform dilatation of the biliary ducts, is usually observed in association with autosomal recessive polycystic kidney disease (ARPKD). Although the diagnosis of ARPKD is generally easy to make in postnatal ultrasound, the diagnosis of Caroli syndrome may be challenging in prenatal ultrasound. Herein, we present a case of a 29-week fetus with ARPKD associated with Caroli syndrome in whom fetal magnetic resonance imaging was essential to identify the "central dot sign" within the dilated biliary ducts to confirm the prenatal diagnosis of Caroli syndrome and to increase our level of confidence in this diagnosis. Read More

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February 2019
1 Read

Optical coherence tomography angiography characteristics in diabetic patients without clinical diabetic retinopathy.

Eye (Lond) 2018 Dec 3. Epub 2018 Dec 3.

Vanderbilt Eye Institute, Nashville, TN, 37232, USA.

Purpose: The purpose of this study is to measure optical coherence tomography angiography (OCTA)-defined retinal vascular and choriocapillaris parameters in diabetic patients without clinically evident diabetic retinopathy.

Methods: Retrospective case series of eyes in patients with a documented history of either type 1 or type 2 diabetes mellitus without any clinical signs of diabetic retinopathy seen at the Vanderbilt Eye Institute. All eyes underwent dilated funduscopic examination along with OCTA. Read More

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December 2018

The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs.

BMC Cell Biol 2018 Dec 3;19(1):26. Epub 2018 Dec 3.

Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London, SE1 1UL, UK.

Background: Endothelial cells provide a barrier between blood and tissues, which is regulated to allow molecules and cells in out of tissues. Patients with cerebral cavernous malformations (CCM) have dilated leaky blood vessels, especially in the central nervous system. A subset of these patients has loss-of-function mutations in CCM3. Read More

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December 2018

How pupil responses track value-based decision-making during and after reinforcement learning.

PLoS Comput Biol 2018 Nov 30;14(11):e1006632. Epub 2018 Nov 30.

Department of Experimental and Applied Psychology, Vrije Universiteit, Amsterdam, Noord-Holland, The Netherlands.

Cognition can reveal itself in the pupil, as latent cognitive processes map onto specific pupil responses. For instance, the pupil dilates when we make decisions and these pupil size fluctuations reflect decision-making computations during and after a choice. Surprisingly little is known, however, about how pupil responses relate to decisions driven by the learned value of stimuli. Read More

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November 2018

Trigeminal Neuralgia Caused by Dural Arteriovenous Fistula in Meckel Cave Treated with Gamma Knife Radiosurgery: A Case Report.

World Neurosurg 2018 Nov 27. Epub 2018 Nov 27.

Department of Radiology, Mayo Clinic, 4500 San Pablo Road S, Jacksonville, Florida, USA, 32224; Department of Neurologic Surgery, Mayo Clinic, Jacksonville, FL, USA, 4500 San Pablo Road S, Jacksonville, Florida, USA. Electronic address:

Background: Classic trigeminal neuralgia is an often debilitating condition that frequently results from vascular compression at the root entry zone of the trigeminal nerve. Here, the authors report a case of dural arteriovenous fistula surrounding the trigeminal nerve from near the root entry zone extending as far ventral as Meckel cave treated solely with Gamma Knife radiosurgery.

Case Description: A 71-year-old woman presented with a history of persistent attacks of right facial pain after failed conservative management. Read More

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November 2018
4 Reads

A case of multinucleate cell angiohistiocytoma in a 14-year old boy showing two different clinical and histopathological findings.

J Cutan Pathol 2018 Nov 29. Epub 2018 Nov 29.

Department of Dermatology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea.

Multinucleate cell angiohistiocytoma (MCAH) is a rare cutaneous disease entity characterized by multiple red-to-brown or violaceous papules usually located on the acral regions such as the face and the distal arms and legs. It affects elderly women more than men and hardly occurs at a young age. The exact pathogenic mechanism of MCAH is not yet clearly understood. Read More

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November 2018
3 Reads

10 Fr S-Type Plastic Pancreatic Stents in Chronic Pancreatitis Are Effective for the Treatment of Pancreatic Duct Strictures and Pancreatic Stones.

Gastroenterol Res Pract 2018 25;2018:6056379. Epub 2018 Oct 25.

Division of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo, Japan.

Aim: Endoscopic pancreatic stenting for refractory pancreatic duct strictures associated with impacted pancreatic stones in chronic pancreatitis cases has yielded conflicting results. We retrospectively evaluated the efficacy of endoscopic treatment in chronic pancreatitis patients with pancreatic duct strictures.

Methods: Pancreatic sphincterotomy, dilatation procedures, pancreatic brush cytology, and pancreatic juice cytology were routinely performed, and malignant diseases were excluded. Read More

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October 2018

Pre-excitation induced ventricular dysfunction and successful berlin heart explantation after accessory pathway ablation.

J Electrocardiol 2018 Nov - Dec;51(6):1067-1070. Epub 2018 Sep 17.

Department of Pediatrics, Pediatric Electrophysiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address:

A 13 kg, 20 month-old, Caucasian girl, presented with cardiomyopathy, biventricular dysfunction and pre-excitation on electrocardiogram. She had normal intracardiac anatomy with severely dilated left ventricle and severely diminished biventricular function (Fig. 1). Read More

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September 2018

Mini-electrodes help identifying hidden slow conduction during ventricular tachycardia substrate ablation.

J Electrocardiol 2018 Nov - Dec;51(6):1011-1013. Epub 2018 Aug 13.

Teknon Medical Center, Barcelona, Spain. Electronic address:

A 69-year-old male with dilated non-ischemic cardiomyopathy and history of sustained monomorphic VT (SMVT) underwent an unsuccessful VT substrate ablation due to the proximity of the earliest activation site to the conduction system. A second attempt was performed using an ablation catheter with mini-electrodes (ME) and multiple extrastimuli to unveil hidden slow conduction (HSC) sites, allowing the performance of a successful ablation. No SMVT was induced thereafter. Read More

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Insulin protects against hepatocyte ultrastructural damage induced by type 1 diabetes mellitus in rats.

Ultrastruct Pathol 2018 Nov 29:1-8. Epub 2018 Nov 29.

a Departments of Physiology , College of Medicine, King Khalid University , Abha , Saudi Arabia.

Diabetic complications that affect vital organs such as the heart and liver represent a major public health concern. The potential protective effects of the hormone insulin against hepatocyte ultrastructural alterations induced secondary to type 1 diabetes mellitus (T1DM) in a rat model of the disease have not been investigated before. Therefore, rats were injected once with 65 mg/kg streptozotocin (T1DM group) and the protection group (T1DM+Ins) received a daily injection of insulin 48 h post diabetic induction by streptozotocin and continued until being sacrificed at week 8. Read More

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November 2018
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Prevalence of Primary Glaucoma as Diagnosed by Study Optometrists of L. V. Prasad eye Institute - Glaucoma Epidemiology and Molecular Genetics Study.

Ophthalmic Epidemiol 2018 Nov 29:1-5. Epub 2018 Nov 29.

d School of Optometry and Vision Science , UNSW , Sydney , Australia.

Purpose: To report the prevalence of primary glaucoma as identified by study optometrists of the L. V. Prasad Eye Institute - Glaucoma Epidemiology and Molecular Genetics Study (LVPEI-GLEAMS). Read More

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November 2018