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Klin Monbl Augenheilkd 2017 04 10;234(4):595-596. Epub 2017 Mar 10.

Augenzentrum Pallas Kliniken, Olten, Switzerland (Director: Prof. Dr. med. Heinrich Gerding, F. E. B. O.).

An Bras Dermatol 2015 Nov-Dec;90(6):780-96; quiz 797-8

Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal.

Benign follicular tumors comprise a large and heterogeneous group of neoplasms that share a common histogenesis and display morphological features resembling one or several portions of the normal hair follicle, or recapitulate part of its embryological development. Most cases present it as clinically nondescript single lesions and essentially of dermatological relevance. Occasionally, however, these lesions be multiple and represent a cutaneous marker of complex syndromes associated with an increased risk of visceral neoplasms. Read More

Am J Dermatopathol 2010 Dec;32(8):749-54

WCP Laboratories Inc., St. Louis, MO 63043, USA.

Hair cortex comedo was described originally in an article detailing 2 cases of a comedo-like clinical lesion that was histologically a keratinous plug with cornification similar to the cortex of the hair shaft. We have collected retro- and prospectively a series of 34 cases of hair cortex comedo. In our series, there was a slight female predominance (Male:Female of 1:1. Read More

Eur J Dermatol 2010 Mar-Apr;20(2):229. Epub 2010 Jan 28.

Ophthalmic Plast Reconstr Surg 2009 Sep-Oct;25(5):411-3

David G. Cogan Ophthalmic Pathology Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA.

A 71-year-old woman had a whitish mass of the outer right lower eyelid with an eccentric pore plugged with keratin. Histopathologic evaluation disclosed an epidermoid cyst that opened widely to the surface and was filled with flaky keratin. The wall displayed a proliferation of rete ridge-type structures that projected in the surrounding dermis. Read More

Actas Dermosifiliogr 2008 Jul-Aug;99(6):456-63

Servicio de Dermatología, Fundación Jiménez Díaz, Madrid, Spain.

Background: Selective immunostaining for calretinin labels the innermost layer of the outer root sheath of normal hair follicles, which is difficult to distinguish with hematoxylin-eosin staining.

Objective: The aim of this study was to determine whether immunohistochemistry for calretinin allows identification of cutaneous adnexal tumors with follicular differentiation towards cells of the outer root sheath.

Material And Methods: We analyzed the staining pattern for calretinin by immunohistochemistry in 49 biopsies of cutaneous adnexal tumors with follicular differentiation. Read More

Indian J Dermatol Venereol Leprol 2002 Jul-Aug;68(4):239-40

Department of Dermato-Venereology, Govt Medical College & Rajindra Hospital, Patiala-147 001, Punjab, India.

Two cases of dilated pore of Winer were observed. First case had single defined black papule with well defined margin, central pore and discharge of black powdery material from nose since 3 years. The second case had one 9 mm, black well-defined papule with central pore discharging black powdery material on right forearm since 9 months and 9 similar smaller papules were seen on forearm and lower abdomen. Read More

Dermatol Surg 2000 Sep;26(9):874-6

Department of Dermatology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

A pore of Winer is a common, benign epidermal appendageal tumor arising from a hair follicle. We present a case where routine removal of a pore of Winer revealed the presence of a trichoid basal cell carcinoma. We describe the history of these lesions, discuss clinical and histologic differential diagnoses, and propose an explanation for the presence of these tumor cells. Read More

Am J Dermatopathol 1996 Jun;18(3):322-5

Department of Dermatology, Kyushu University Faculty of Medicine, Fukuoka, Japan.

We report two cases of skin lesions that clinically resemble a comedo. Both lesions demonstrated a firm black papule which was histopathologically reminiscent of a dilated hair follicle associated with an abnormality of the hair cortex. These findings are thus considered to represent a unique and peculiar variant of the dilated pore of Winer, and the term "hair cortex comedo" is therefore believed to be suitable for such lesions. Read More

Am J Dermatopathol 1993 Apr;15(2):169-71

Hahnemann University Hospital, Department of Medicine, Philadelphia, Pennsylvania 19102.

Histology of a nevus comedonicus showed aggregates of dilated follicular cysts reminiscent of dilated pore of Winer. This finding has not been previously reported. We propose the term dilated pore nevus for this lesion, which we conceive to be a histologic variant of nevus comedonicus, similar to porokeratotic eccrine ostial and dermal duct nevus. Read More

G Ital Dermatol Venereol 1990 May;125(5):197-9

Istituto di Clinica Dermatologica, II Cattedra, Università di Torino.

A 23-year-old man with a keratotic-nodular lesion localized on the neck since infancy is reported. Histologically, there was a funnel-shaped follicle with central horny material and multiple digitations of the follicular sheath epithelium with some features resembling dilated pore of Winer. In addition, there were pale dyskeratotic epithelial cells in the infundibular portion of the tumor and in the surrounding epidermis. Read More

J Comp Pathol 1989 Nov;101(4):375-9

New York State College of Veterinary Medicine, Cornell University, Ithaca, New York.

A retrospective study of 125 cutaneous cystic lesions in cats from 1978 to 1987 Revealed 14 examples of the dilated pore of Winer, a lesion previously described in man and in one cat. Histologically, this lesion appears as a flasklike cystic structure with a wide external opening and laminated keratinaceous content. The cyst is characterized by a thickened wall with numerous, closely apposed rete ridges, either at its base or throughout most of the circumference, with a thinner atrophic wall approaching the os. Read More

Med Cutan Ibero Lat Am 1989 ;17(1):45-7

Cátedra y Servicio de Dermatología, Hospital Clínico, Barcelona, España.

Dilated pore (Winer) is a not uncommon adnexal benign tumor with follicular differentiation. Clinically the lesion looks like a giant comedo, usually located on the facial area of the elderly. Due to annular elevation of the borders, differential diagnosis needs to be made with basal cell epithelioma and senile sebaceous adenoma. Read More

Hautarzt 1983 May;34(5):209-16

This report presents clinical and histological data of dilated pores of 54 biopsies from 45 patients from Munich and 39 biopsies from 36 patients from Detroit. The dilated pore of Winer is a relatively common benign adnexal tumor originating from the outer hair root sheath. Three-dimensional reconstructions of the tumor show that four different types of dilated pores can be considered. Read More

Ann Dermatol Venereol 1981 ;108(1):59-66

Tricholemmal adnexal pilar tumors may be classified according to the tricholemmal zone whose structure they reproduce and according to their degree of maturation or dedifferentiation. The pilar sheath acanthoma (dilated pore of Winer), the tumor of follicular infundibulum and the follicular poroma (inverted follicular keratosis) are related to the infundibulum and keratinize according to the epidermal pattern. The tricholemmal cysts (of simple or proliferating type) and the keratinizing tricholemmoma are related to the upper part of the isthmus of the anagen hair and keratinize according to the specific pattern of the outer root sheath at this isthmic level. Read More

J Invest Dermatol 1954 Sep;23(3):181-8