50,201 results match your criteria Dilated Cardiomyopathy
Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):429-433. Epub 2018 Nov 30.
Instituto Mexicano del Seguro Social, Hospital de Cardiología, Servicio de Anestesiología. Ciudad de México, México
Background: Extracorporeal membrane oxygenation is a technique indicated in cases of severe respiratory failure or in situations where pump failure or heart failure is refractory to conventional medical treatment. Our goal was to describe the results of a patient with chronic Chagas dilated cardiomyopathy treated with extracorporeal membrane oxygenation as bridging therapy for heart transplantation.
Case Report: A 62-year old male with a history of Chagas disease and severe ventricular failure who underwent veno-arterial extracorporeal membrane oxygenation as bridging therapy for heart transplantation, with good clinical evolution. Read More
Int Heart J 2018 Dec 5. Epub 2018 Dec 5.
Cardiovascular Center, Onze Lieve Vrouw Ziekenhuis.
This study aimed to examine the relationship between corin expression and circulating brain natriuretic peptide in patients with left ventricular (LV) dysfunction.Circulating levels of B-type natriuretic peptide (BNP) can be an indicator of LV dysfunction. The 32-amino-acid BNP is cleaved by corin, a cardiac serine protease, from its108-amino-acid pro-brain natriuretic peptide (proBNP) precursor. Read More
J Biol Chem 2018 Dec 5. Epub 2018 Dec 5.
Cellular and Molecular Physiology, Penn State University College of Medicine, United States.
Myosins are molecular motors that use a conserved ATPase cycle to generate force. We investigated two mutations in the converter domain of myosin V (R712G and F750L) to examine how altering specific structural transitions in the motor ATPase cycle can impair myosin mechanochemistry. The corresponding mutations in the human beta-cardiac myosin gene are associated with hypertrophic and dilated cardiomyopathy, respectively. Read More
J Med Genet 2018 Dec 5. Epub 2018 Dec 5.
The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University, Beer Sheva, Israel.
Background: Dilated cardiomyopathy (DCM) is a primary myocardial disease leading to contractile dysfunction, progressive heart failure and excessive risk of sudden cardiac death. Around half of DCM cases are idiopathic, and genetic factors seem to play an important role.
Aim: We investigated a possible genetic cause of DCM in two consanguineous children from a Bedouin family. Read More
Acta Cardiol 2018 Dec 3:1-7. Epub 2018 Dec 3.
a Dipartimento di Medicina Interna e Scienze Biomediche, Sezione di Cardiologia , Università degli Studi di Parma , Parma , Italy.
Background: We aimed to depict the electrocardiographic and echocardiographic aspects in patients before elective major vascular surgery.
Methods: We evaluated through standard 12 lead electrocardiography and transthoracic echocardiography 469 patients with asymptomatic large abdominal aortic aneurysm (AAA), 334 with critical carotid stenosis (CAS), and 238 with advanced peripheral artery disease (PAD) before surgical revascularization.
Results: Patients with AAA were predominantly males (p < . Read More
Brain Behav 2018 Dec 3:e01167. Epub 2018 Dec 3.
Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, China.
Introduction: Emery-Dreifuss muscular dystrophy (EDMD) is a hereditary myopathy characterized as triad of muscular dystrophy, joint contractures, and conduction cardiomyopathy. In this study, we diagnosed a X-linked recessive EDMD patient with severe conduction cardiomyopathy while noteless muscular and joint disorders.
Methods: A Chinese cardiomyopathy family spanning four generations was enrolled in the study. Read More
J Cell Mol Med 2018 Dec 1. Epub 2018 Dec 1.
Department of Nephrology, The First Affiliated Hospital of Air Force Medical University, Xi'an, Shaanxi, China.
SUMOylation of proteins is an important regulatory element in modulating protein function and has been implicated in the pathogenesis of numerous human diseases such as cancers, neurodegenerative diseases, brain injuries, diabetes, and familial dilated cardiomyopathy. Growing evidence has pointed to a significant role of SUMO in kidney diseases such as DN, RCC, nephritis, AKI, hypertonic stress and nephrolithiasis. Recently, emerging studies in podocytes demonstrated that SUMO might have a protective role against podocyte apoptosis. Read More
Eur J Pediatr 2018 Dec 1. Epub 2018 Dec 1.
Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 80138, Naples, Italy.
Antibiotics are often used to prevent post-catheterization urinary tract infections (UTIs) in patients undergoing cystography. However, there is no universally accepted protocol and the literature data are conflicting. We aimed to determine prevalence and risk factors of post-cystography UTIs in non-toilet-trained children. Read More
Heart Views 2018 Apr-Jun;19(2):71-73
Department of General Medicine, MES Medical College, Malappuram, Kerala, India.
We present a 32-year-old woman with no morbidities who was admitted with a dilated cardiomyopathy and cardiac failure due to adrenocortical carcinoma (ACC) which improved completely with surgical resection. Awareness regarding such rare presentations can avoid undue delay in diagnosis and management. Read More
Oman J Ophthalmol 2018 Sep-Dec;11(3):274-276
2nd Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, "Papageorgiou" General Hospital, 564 03 Thessaloniki, Macedonia, Greece.
We aim to present a case of bilateral rhegmatogenous retinal detachment (RRD) after successful phacoemulsification procedures performed 23 years before RRD onset and surgical management. A 57-year-old female presented with blurred vision due to floaters in the left eye. The patient was followed up with dilated fundus examination. Read More
Nat Commun 2018 Nov 30;9(1):5107. Epub 2018 Nov 30.
Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon 16419, Korea.
Dysregulation of Ca/calmodulin-dependent protein kinase (CaMK)II is closely linked with myocardial hypertrophy and heart failure. However, the mechanisms that regulate CaMKII activity are incompletely understood. Here we show that protein arginine methyltransferase 1 (PRMT1) is essential for preventing cardiac CaMKII hyperactivation. Read More
Medicina (B Aires) 2018 ;78(6):443-446
Centro de Medicina Respiratoria, Hospital Británico de Buenos Aires, Argentina.
Multiple myeloma is a hematologic disease, which accounts for 15% of hematologic malignancies. The average age of onset is between 65-70 years and is very rare in young patients, as 2% are under 40 years old. We present a case of 36-year-old women with history of 20 pack years (p/y) smoking, who complaints of dyspnea associated with signs of right cardiac overload, anemia, proteinuria, elevated acute phase reactants and spirometry pattern suggestive of moderately-severe restriction and severe drop in diffusing capacity for carbon monoxide (DLCO). Read More
Mol Cell Endocrinol 2018 Nov 29. Epub 2018 Nov 29.
Department of Endocrinology, The Third Affiliated Hospital of Soochow University, Changzhou City, 213003, China. Electronic address:
Background And Aims: Obstructive sleep apnea syndrome is a chronic disease associated with intermittent hypoxia (IH) and is an important risk factor for cardiovascular disease. Glucagon-like peptide (GLP-1) is a naturally occurring incretin used as a promising therapeutic agent in the treatment of acute myocardial infarction, dilated cardiomyopathy, and advanced heart failure. However, whether GLP-1 can protect against IH-induced cardiac injury is still unclear. Read More
Fertil Steril 2018 Dec;110(7):1410-1411
Department of Urology, University of Miami, Miami, Florida. Electronic address:
Objective: To demonstrate a safe and effective approach to the treatment of obstructing midline prostate utricle cyst with the use of a holmium laser.
Design: Video presentation.
Setting: University hospital. Read More
J Plast Reconstr Aesthet Surg 2018 Nov 2. Epub 2018 Nov 2.
Department of Hand and Plastic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, 109 West Xue Yuan Road, Lu Cheng District, Wenzhou 325000 China. Electronic address:
Background: Necrosis of propeller flaps is a problem in clinical practice. This study was performed to investigate the effects of pedicle torsion on dynamic perforasome survival using a multiterritory perforator flap model in rats.
Methods: Intercostal artery perforator flaps (IC flaps) containing two adjacent dynamic perforasomes were applied to both sides of the dorsum in 15 rats. Read More
PLoS One 2018 5;13(12):e0202838. Epub 2018 Dec 5.
Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.
Objectives: We hypothesized that systemic administration of high-mobility group box 1 fragment attenuates the progression of myocardial fibrosis and cardiac dysfunction in a hamster model of dilated cardiomyopathy by recruiting bone marrow mesenchymal stem cells thus causing enhancement of a self-regeneration system.
Methods: Twenty-week-old J2N-k hamsters, which are δ-sarcoglycan-deficient, were treated with systemic injection of high-mobility group box 1 fragment (HMGB1, n = 15) or phosphate buffered saline (control, n = 11). Echocardiography for left ventricular function, cardiac histology, and molecular biology were analyzed. Read More
Surg Laparosc Endosc Percutan Tech 2018 Dec 3. Epub 2018 Dec 3.
Department of Surgery, University of Buenos Aires.
Purpose: The present study aimed to determine whether the percentage of bleeding complications differs between the right and the left approaches in percutaneous biliary drainage (PBD) in adult patients.
Materials And Methods: This was a prospective, descriptive, nonrandomized comparative and longitudinal study. We included adult patients over 18 years of age who underwent a PBD. Read More
J Endovasc Ther 2018 Dec 4:1526602818816656. Epub 2018 Dec 4.
1 Department of Vascular and Endovascular Surgery, IRCCS Sacro Cuore Don Calabria, Negrar, Italy.
Purpose: To evaluate the safety and efficacy of carotid artery stenting (CAS) performed without an embolic protection device (EPD) in a selected group of asymptomatic patients with primary internal carotid artery (ICA) stenosis or restenosis after carotid endarterectomy (CEA).
Materials And Methods: Between May 2015 and May 2018, 77 patients (mean age 77 years; 60 men) underwent CAS without any embolic protection device. Forty-seven (61%) patients had primary ICA stenosis and were excluded from CEA because of high surgical risk; the other 30 (39%) patients had post-CEA restenosis (n=26) or a distal ICA flap after eversion CEA (n=4). Read More
Rev Prat 2017 Apr;67(4):421-423
Service de cardiologie, centre hospitalier universitaire Ibn Rochd, Casablanca, Maroc.
Peripartum cardiomyopathy. Peripartum cardiomyopathy (PPCM) is a dilated cardiomyopathy occurring during or following pregnancy in the absence of pre-existing heart disease. The aetiology is still uncertain. Read More
Neuroimage 2018 Dec 1. Epub 2018 Dec 1.
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, 11794, USA. Electronic address:
Cocaine is a highly addictive drug with complex pharmacological effects. Most preclinical imaging studies investigating the effects of cocaine in the brain have been performed under anesthesia, which confounds findings. To tackle this problem, we used optical imaging to compare the effects of cocaine in the awake versus the anesthetized state. Read More
Case Rep Gastrointest Med 2018 30;2018:7091520. Epub 2018 Oct 30.
Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
In this report, we described two patients with white globe appearance in autoimmune atrophic gastritis. Endoscopy revealed multiple white substances in the stomach in both cases. Biopsied specimens from the lesions contained dilated glands and showed a decrease in parietal cells. Read More
Radiol Case Rep 2019 Feb 26;14(2):265-268. Epub 2018 Nov 26.
Department of Radiology, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 10104, USA.
Caroli syndrome, which is characterized by saccular and fusiform dilatation of the biliary ducts, is usually observed in association with autosomal recessive polycystic kidney disease (ARPKD). Although the diagnosis of ARPKD is generally easy to make in postnatal ultrasound, the diagnosis of Caroli syndrome may be challenging in prenatal ultrasound. Herein, we present a case of a 29-week fetus with ARPKD associated with Caroli syndrome in whom fetal magnetic resonance imaging was essential to identify the "central dot sign" within the dilated biliary ducts to confirm the prenatal diagnosis of Caroli syndrome and to increase our level of confidence in this diagnosis. Read More
Eye (Lond) 2018 Dec 3. Epub 2018 Dec 3.
Vanderbilt Eye Institute, Nashville, TN, 37232, USA.
Purpose: The purpose of this study is to measure optical coherence tomography angiography (OCTA)-defined retinal vascular and choriocapillaris parameters in diabetic patients without clinically evident diabetic retinopathy.
Methods: Retrospective case series of eyes in patients with a documented history of either type 1 or type 2 diabetes mellitus without any clinical signs of diabetic retinopathy seen at the Vanderbilt Eye Institute. All eyes underwent dilated funduscopic examination along with OCTA. Read More
BMC Cell Biol 2018 Dec 3;19(1):26. Epub 2018 Dec 3.
Randall Centre for Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London, SE1 1UL, UK.
Background: Endothelial cells provide a barrier between blood and tissues, which is regulated to allow molecules and cells in out of tissues. Patients with cerebral cavernous malformations (CCM) have dilated leaky blood vessels, especially in the central nervous system. A subset of these patients has loss-of-function mutations in CCM3. Read More
PLoS Comput Biol 2018 Nov 30;14(11):e1006632. Epub 2018 Nov 30.
Department of Experimental and Applied Psychology, Vrije Universiteit, Amsterdam, Noord-Holland, The Netherlands.
Cognition can reveal itself in the pupil, as latent cognitive processes map onto specific pupil responses. For instance, the pupil dilates when we make decisions and these pupil size fluctuations reflect decision-making computations during and after a choice. Surprisingly little is known, however, about how pupil responses relate to decisions driven by the learned value of stimuli. Read More
World Neurosurg 2018 Nov 27. Epub 2018 Nov 27.
Department of Radiology, Mayo Clinic, 4500 San Pablo Road S, Jacksonville, Florida, USA, 32224; Department of Neurologic Surgery, Mayo Clinic, Jacksonville, FL, USA, 4500 San Pablo Road S, Jacksonville, Florida, USA. Electronic address:
Background: Classic trigeminal neuralgia is an often debilitating condition that frequently results from vascular compression at the root entry zone of the trigeminal nerve. Here, the authors report a case of dural arteriovenous fistula surrounding the trigeminal nerve from near the root entry zone extending as far ventral as Meckel cave treated solely with Gamma Knife radiosurgery.
Case Description: A 71-year-old woman presented with a history of persistent attacks of right facial pain after failed conservative management. Read More
J Cutan Pathol 2018 Nov 29. Epub 2018 Nov 29.
Department of Dermatology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea.
Multinucleate cell angiohistiocytoma (MCAH) is a rare cutaneous disease entity characterized by multiple red-to-brown or violaceous papules usually located on the acral regions such as the face and the distal arms and legs. It affects elderly women more than men and hardly occurs at a young age. The exact pathogenic mechanism of MCAH is not yet clearly understood. Read More
Gastroenterol Res Pract 2018 25;2018:6056379. Epub 2018 Oct 25.
Division of Gastroenterology and Hepatology, Toho University Omori Medical Center, Tokyo, Japan.
Aim: Endoscopic pancreatic stenting for refractory pancreatic duct strictures associated with impacted pancreatic stones in chronic pancreatitis cases has yielded conflicting results. We retrospectively evaluated the efficacy of endoscopic treatment in chronic pancreatitis patients with pancreatic duct strictures.
Methods: Pancreatic sphincterotomy, dilatation procedures, pancreatic brush cytology, and pancreatic juice cytology were routinely performed, and malignant diseases were excluded. Read More
J Electrocardiol 2018 Nov - Dec;51(6):1067-1070. Epub 2018 Sep 17.
Department of Pediatrics, Pediatric Electrophysiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address:
A 13 kg, 20 month-old, Caucasian girl, presented with cardiomyopathy, biventricular dysfunction and pre-excitation on electrocardiogram. She had normal intracardiac anatomy with severely dilated left ventricle and severely diminished biventricular function (Fig. 1). Read More
J Electrocardiol 2018 Nov - Dec;51(6):1011-1013. Epub 2018 Aug 13.
Teknon Medical Center, Barcelona, Spain. Electronic address:
A 69-year-old male with dilated non-ischemic cardiomyopathy and history of sustained monomorphic VT (SMVT) underwent an unsuccessful VT substrate ablation due to the proximity of the earliest activation site to the conduction system. A second attempt was performed using an ablation catheter with mini-electrodes (ME) and multiple extrastimuli to unveil hidden slow conduction (HSC) sites, allowing the performance of a successful ablation. No SMVT was induced thereafter. Read More
Ultrastruct Pathol 2018 Nov 29:1-8. Epub 2018 Nov 29.
a Departments of Physiology , College of Medicine, King Khalid University , Abha , Saudi Arabia.
Diabetic complications that affect vital organs such as the heart and liver represent a major public health concern. The potential protective effects of the hormone insulin against hepatocyte ultrastructural alterations induced secondary to type 1 diabetes mellitus (T1DM) in a rat model of the disease have not been investigated before. Therefore, rats were injected once with 65 mg/kg streptozotocin (T1DM group) and the protection group (T1DM+Ins) received a daily injection of insulin 48 h post diabetic induction by streptozotocin and continued until being sacrificed at week 8. Read More
Ophthalmic Epidemiol 2018 Nov 29:1-5. Epub 2018 Nov 29.
d School of Optometry and Vision Science , UNSW , Sydney , Australia.
Purpose: To report the prevalence of primary glaucoma as identified by study optometrists of the L. V. Prasad Eye Institute - Glaucoma Epidemiology and Molecular Genetics Study (LVPEI-GLEAMS). Read More
Mol Cell Biochem 2018 Nov 28. Epub 2018 Nov 28.
Department of Experimental Medicine and Biotechnology, PGIMER, Lab No 2009, Research Block B, Chandigarh, 160012, India.
In the original publication of the article, the location and rs number of TNNI3K mouse SNP (3784 C>T) (rs49812611) has been mentioned inadvertently in place of its human homologue. The correct information for human SNP is rs760769780 located at position 74436534, resulting in (G>A) change in human TNNI3K gene. Read More
Int J Organ Transplant Med 2018 1;9(3):137-139. Epub 2018 Aug 1.
Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Concomitant replacement of the ascending aorta and heart transplantation are an infrequent procedure. This procedure was most often performed in patients with Marfan syndrome, however, it has its own technical difficulties. Hereby, we report on combined heart transplantation and aortic root replacement using donor's ascending aorta in a 25-year-old man diagnosed with dilated cardiomyopathy and ascending aorta aneurysm. Read More
Nat Commun 2018 Nov 28;9(1):5033. Epub 2018 Nov 28.
Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, 02118, USA.
Inflammatory diseases of the pancreas have no specific therapy. Discovery of the genetic basis of chronic pancreatitis identified the digestive enzyme trypsin as a therapeutic target. Preclinical testing of trypsin inhibition has been hampered by the lack of animal models. Read More
Cold Spring Harb Mol Case Stud 2018 Nov 28. Epub 2018 Nov 28.
Exome sequencing is increasingly utilized in both clinical and non-clinical settings, but little is known about its utility in healthy individuals. Most previous studies on this topic have examined a small subset of genes known to be implicated in human disease and/or have used automated pipelines to assess pathogenicity of known variants. In order to determine the frequency of both medically actionable and non-actionable but medically relevant exome findings in the general population we assessed the exomes of 70 participants who have been extensively characterized over the past several years as part of a longitudinal integrated multi-omics profiling study. Read More
Aerosp Med Hum Perform 2018 Dec;89(12):1089-1091
A number of ophthalmic abnormalities, including optic disc edema, have been reported in several astronauts involved in long-duration spaceflights. An increased understanding of factors contributing to this syndrome, initially designated visual impairment and intracranial pressure syndrome and recently renamed spaceflight-associated neuro-ocular syndrome, has become a high priority for ESA and NASA, especially in view of future long-duration missions, including trips to Mars. The underlying pathophysiological mechanisms of this syndrome are still not well understood. Read More
Zootaxa 2018 Nov 13;4521(1):89-115. Epub 2018 Nov 13.
Institut de Biologia Evolutiva (CSIC-Universitat Pompeu Fabra), 08003 Barcelona, Spain..
In this article, I describe a new endemic genus of New Caledonian Eumolpinae, Kumatoeides gen. nov. (tribe Eumolpini), and eight new species currently conforming the genus: K. Read More
Zootaxa 2018 Nov 25;4524(5):581-594. Epub 2018 Nov 25.
Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, 690022, Russia..
Grammapsychops lebedevi Martynova, 1954 from the Late Cretaceous (Cenomanian) of Siberia is re-described based on the holotype. The species is represented by a hind wing as its CuA is definitely concave, although the costal space is strongly dilated. This genus together with three other Cretaceous genera (i. Read More
Zootaxa 2018 Oct 18;4500(4):517-542. Epub 2018 Oct 18.
Laboratório de Ecologia e Evolução, Escola de Artes, Ciências e Humanidades (EACH), Universidade de São Paulo (USP), Av. Arlindo Bettio, 1000, São Paulo, SP, 03828-000, Brazil.
The Brazilian land planarians Cratera crioula, C. joia, Geoplana hina, and G. taxiarcha (Platyhelminthes, Tricladida, Geoplanidae) are revised taxonomically from type material and additional specimens. Read More
Zootaxa 2018 Oct 31;4508(2):151-178. Epub 2018 Oct 31.
USDA APHIS PPQ South Florida, P.O. Box 660520, Miami, FL 33266, USA..
Ceratophila new genus (Erotylidae: Pharaxonothinae) inhabiting male cones of the Mesoamerican cycad genus Ceratozamia Brongniart (Zamiaceae) is described for seven new species and compared to other genera of the Pharaxonothinae. Ceratophila differs from other genera of the Pharaxonothinae in many characters, most notable of which are: lateral pronotal carina thicker anteriorly in lateral view; head with supraocular and transverse occipital lines; elytra lacking a basal bead; and stridulatory files at base of head narrowly separated. Ceratophila has the male genitalia laterally compressed with a short median lobe and flagellum, similar to other Erotylidae. Read More
Congenit Heart Dis 2018 Nov 28. Epub 2018 Nov 28.
Department of Cardiology, Katip Çelebi University Atatürk Training and Research Hospital, Izmir, Turkey.
Objective: The bicuspid aortic valve (BAV) is the most common congenital heart disease. The process of aortic dilatation is not completely clear in patients with the BAV. Apelin is a peptide found at high levels in vascular endothelial cells which has a role in vascular regulation and cardiovascular function. Read More
PLoS One 2018 28;13(11):e0208100. Epub 2018 Nov 28.
Yonsei University Health System, Yonsei Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Introduction: The presence of late gadolinium enhancement (LGE) at the right ventricular insertion point (RVIP) on cardiac magnetic resonance (CMR) is generally believed to be nonspecific, but the clinical implication of this unique LGE pattern in patients with non-ischemic dilated cardiomyopathy (NICM) has not been elucidated.
Objectives: We investigated the prognostic significance of RVIP-LGE in NICM patients.
Methods: A total of 360 consecutive NICM patients referred for CMR (102 with no LGE, 50 with RVIP-LGE, 121 with left ventricular [LV]-LGE, and 87 with both an LV and RVIP-LGE) were studied. Read More
Braz J Med Biol Res 2018 Nov 23;52(1):e7914. Epub 2018 Nov 23.
Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China.
Yes-associated protein (YAP) is an important regulator of cellular proliferation and transdifferentiation. However, little is known about the mechanisms underlying myofibroblast transdifferentiation in dilated cardiomyopathy (DCM). We investigated the role of YAP in the pathological process of cardiac matrix remodeling. Read More
Cardiol J 2018 Nov 28. Epub 2018 Nov 28.
Collegium Medicum of Jagiellonian University, Department of Cardiac and Vascular Diseases, John Paul II Hospital, Kraków, Poland, ul.Prądnicka 80, 31-202 Cracow, Poland.
Background: Fibrosis of the extracellular matrix (ECM) in dilated cardiomyopathy (DCM) is common and compromises both systolic and diastolic function. The aim of this study was to investigate the kinetics of ECM fibrosis markers over a 12 month follow-up in patients with DCM based on the severity of diastolic dysfunction (DD).
Methods: Seventy consecutive DCM patients (48 ± 12. Read More
Indian J Pediatr 2018 Nov 28. Epub 2018 Nov 28.
Department of Medical Genetics, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.
Cardiomyopathy is an etiologically heterogeneous condition, and non-syndromic as well as syndromic genetic causes are identified in a significant proportion of cases without a known acquired cause. The present report describes a 2-mo-old boy who presented initially with a referral diagnosis of isolated dilated cardiomyopathy, without any associated dysmorphism or malformations, and with history of similar cardiac disease and early infantile death in an elder male sibling. Next generation sequencing (NGS) based multigene panel testing of the cardiomyopathy-associated genes was done which revealed the diagnosis of Alström syndrome, based on which appropriate management and surveillance could be planned for the child and accurate genetic counseling could be provided to the parents. Read More
Neth Heart J 2018 Nov 27. Epub 2018 Nov 27.
Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands.
Graefes Arch Clin Exp Ophthalmol 2018 Nov 27. Epub 2018 Nov 27.
Department of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, D-53127, Bonn, Germany.
Purpose: To determine the prevalence of and identify factors associated with visual impairment and blindness in institutionalized elderly in Germany.
Methods: In this prospective multicenter cross-sectional study, ophthalmic health care need and provision were investigated in institutionalized elderly in 32 nursing homes in Germany. All participants underwent a standardized examination including medical and ocular history, refraction, visual acuity testing, tonometry, biomicroscopy, and dilated funduscopy. Read More
Heart Lung Circ 2018 Oct 11. Epub 2018 Oct 11.
Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia; St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia; Cardiology Department, St. Vincent's Hospital, Sydney, NSW, Australia. Electronic address:
Cardiac arrhythmias are frequently seen in patients with dilated cardiomyopathy (DCM) and can precipitate heart failure and death. In patients with non-ischaemic DCM, evidence for the benefit of an implantable cardioverter-defibrillator (ICD) for primary prevention of sudden cardiac death has recently been questioned. Algorithms devised to identify high-risk individuals who might benefit most from ICD implantation have focussed on clinical criteria with little attention paid to the underlying aetiology of DCM. Read More
Int J Cardiol 2018 Oct 23. Epub 2018 Oct 23.
Department of Inherited Neuro-metabolic Disorders, Anna Meyer Children's Hospital, viale Pieraccini 24, 50159 Florence, Italy. Electronic address:
Background: Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like (MELAS) syndrome is a rare condition with heterogeneous clinical presentation. Cardiac involvement commonly develops during adulthood, comprising both structural and conduction/arrhythmic abnormalities; early paediatric onset has rarely been reported. We describe the clinical profile, outcome and clinical implication of MELAS-associated cardiomyopathy at a tertiary referral centre. Read More