24,383 results match your criteria Dilated Cardiomyopathy

Clinical Characteristics and Predictors of In-Hospital Mortality in Patients With Cardiogenic Shock: Results From the RESCUE Registry.

Circ Heart Fail 2021 Jun 15;14(6):e008141. Epub 2021 Jun 15.

Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center (J.H.Y., K.H.C., T.K.P., J.M.L., Y.B.S., J.-Y.H., S.-H.C., H.-C.G.), Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: In the current era of mechanical circulatory support, limited data are available on prognosis of cardiogenic shock (CS) caused by various diseases. We investigated the characteristics and predictors of in-hospital mortality in Korean patients with CS.

Methods: The RESCUE study (Retrospective and Prospective Observational Study to Investigate Clinical Outcomes and Efficacy of Left Ventricular Assist Device for Korean Patients With CS) is a multicenter, retrospective, and prospective registry of patients that presented with CS. Read More

View Article and Full-Text PDF

SARS-CoV-2 infection associated severe dilated cardiomyopathy in a 4-week-old infant.

IDCases 2021 Jun 10:e01178. Epub 2021 Jun 10.

Western Michigan University Homer Stryker School of Medicine and Bronson Children's Hospital, Kalamazoo, MI, United States.

Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious complication associated with COVID-19. It can lead to an inflammatory process in multiple body parts, including the heart, lungs, kidneys, and the brain. In this review, we describe the case of a 4-week-old infant with severe isolated systolic dysfunction who was found to be positive for COVID-19. Read More

View Article and Full-Text PDF

Attenuated strain of CVB3 with a mutation in the CAR-interacting region protects against both myocarditis and pancreatitis.

Sci Rep 2021 Jun 14;11(1):12432. Epub 2021 Jun 14.

School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA.

Coxsackievirus B3 (CVB3), is commonly implicated in myocarditis, which can lead to dilated cardiomyopathy, in addition to causing acute pancreatitis and meningitis. Yet, no vaccines are currently available to prevent this infection. Here, we describe the derivation of a live attenuated vaccine virus, termed mutant (Mt) 10, encoding a single amino acid substitution H790A within the viral protein 1, that prevents CVB3 infection in mice and protects from both myocarditis and pancreatitis in challenge studies. Read More

View Article and Full-Text PDF

Prognostic implications of troponin T variations in inherited cardiomyopathies using systems biology.

NPJ Genom Med 2021 Jun 14;6(1):47. Epub 2021 Jun 14.

Cardiology department, Health In Code. As Xubias s/n, Edificio El Fortín, 15006, A Coruña, Spain.

The cardiac troponin T variations have often been used as an example of the application of clinical genotyping for prognostication and risk stratification measures for the management of patients with a family history of sudden cardiac death or familial cardiomyopathy. Given the disparity in patient outcomes and therapy options, we investigated the impact of variations on the intermolecular interactions across the thin filament complex as an example of an unbiased systems biology method to better define clinical prognosis to aid future management options. We present a novel unbiased dynamic model to define and analyse the functional, structural and physico-chemical consequences of genetic variations among the troponins. Read More

View Article and Full-Text PDF

Could the unfortunate outcome of pediatric acute myocarditis be predicted? Factors contributing to a poor outcome in myocarditis.

Rev Port Cardiol 2021 Jun 11. Epub 2021 Jun 11.

Cardiology Department, Mother and Child Health Institute of Serbia, Belgrade, Serbia; School of Medicine, University of Belgrade, Belgrade, Serbia. Electronic address:

Objective: Myocarditis has spontaneous resolution in 50% of patients. Our study aimed to define risk factors for developing dilated cardiomyopathy (DCM) and death in pediatric patients with acute myocarditis (AM).

Methods: The retrospective cohort study included all patients with treated AM. Read More

View Article and Full-Text PDF

Genome editing in cardiovascular diseases.

Indra Mani

Prog Mol Biol Transl Sci 2021 22;181:289-308. Epub 2021 Feb 22.

Department of Microbiology, Gargi College, University of Delhi, New Delhi, India. Electronic address:

Genetic modification at the molecular level in somatic cells, germline, and animal models requires for different purposes, such as introducing desired mutation, deletion of alleles, and insertion of novel genes in the genome. Various genome-editing tools are available to accomplish these alterations, such as zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated (Cas) system. CRISPR-Cas system is an emerging technology, which is being used in biological and medical sciences, including in the cardiovascular field. Read More

View Article and Full-Text PDF
February 2021

[Clinical and genetic characteristics of different types of non-obstructive hypertrophic cardiomyopathy].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Jun;49(6):593-600

Department of Cardiomyopathy, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China State Key Laboratory of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

To analyze the clinical and genetic characteristics of clinical subtypes of non-obstructive hypertrophic cardiomyopathy (HCM). It was a cohort study. Patients with non-obstructive HCM admitted to Fuwai Hospital, Chinese Academy of Medical Sciences, from January 1999 to April 2019 were enrolled. Read More

View Article and Full-Text PDF

A case report of cobalt cardiomyopathy leading to electric storm and cardiogenic shock: the importance of the orthopaedic background in patients with heart failure of unknown aetiology.

Eur Heart J Case Rep 2021 Apr 5;5(4):ytab057. Epub 2021 Apr 5.

Department of Cardiology, Hospital Universitario Marqués de Valdecilla, Avenida Valdecilla 25, Santander 39008, Spain.

Background : The first series of cobalt cardiomyopathy was described in the 60s in relation to the abuse of a cobalt containing beer. Since then, millions of metal hip arthroplasties have been performed and a small number of cobalt cardiomyopathies related to metal prosthesis have been reported.

Case Summary : We report a case of a 48-year-old man who developed a severe non-dilated restrictive cardiomyopathy in the setting of a systemic metallosis following several hip arthroplasties. Read More

View Article and Full-Text PDF

Sex-Specific Differences of the Inflammatory State in Experimental Autoimmune Myocarditis.

Front Immunol 2021 28;12:686384. Epub 2021 May 28.

Institute for Gender in Medicine, Center for Cardiovascular Research, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt - Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.

Increasing evidence suggests male sex as a potential risk factor for a higher incidence of cardiac fibrosis, stronger cardiac inflammation, and dilated cardiomyopathy (DCM) in human myocarditis. Chronic activation of the immune response in myocarditis may trigger autoimmunity. The experimental autoimmune myocarditis (EAM) model has been well established for the study of autoimmune myocarditis, however the role of sex in this pathology has not been fully explored. Read More

View Article and Full-Text PDF

Dilated cardiomyopathy and mild limb girdle muscular dystrophy caused by the p.Gly424Ser genetic variant in the fukutin gene.

Rev Esp Cardiol (Engl Ed) 2021 Jun 11. Epub 2021 Jun 11.

Unidad de Cardiopatías Familiares, Complexo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain; Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain; Faculdade de Medicina, Universidade da Coruña (UDC), A Coruña, Spain; Servizo Galego de Saúde (SERGAS), Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain.

View Article and Full-Text PDF

Heart Rate as a Marker of Relapse During Withdrawal of Therapy in Recovered Dilated Cardiomyopathy.

JACC Heart Fail 2021 Jun 3. Epub 2021 Jun 3.

Cardiovascular Research Centre, Royal Brompton Hospital and National Heart Lung Institute, Imperial College, London, United Kingdom. Electronic address:

Objectives: The objective of this study was to determine the relationship between heart rate and relapse among patients in the TRED-HF (Therapy withdrawal in REcovered Dilated cardiomyopathy trial).

Background: Understanding markers and mechanisms of relapse among patients with recovered dilated cardiomyopathy (DCM) may enable personalized management.

Methods: The relationship between serial heart rate measurements and relapse was examined among patients in the TRED-HF trial, a randomized trial which examined the safety and feasibility of withdrawing heart failure therapy from 51 patients with recovered DCM over 6 months. Read More

View Article and Full-Text PDF

AIM2-driven inflammasome activation in heart failure.

Cardiovasc Res 2021 Jun 12. Epub 2021 Jun 12.

Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.

Aims: Interleukin-1β (IL-1β) is an important pathogenic factor in cardiovascular diseases including chronic heart failure (HF). The CANTOS trial highlighted that inflammasomes as primary sources of IL-1 β are promising new therapeutic targets in cardiovascular diseases. Therefore, we aimed to assess inflammasome activation in failing hearts to identify activation patterns of inflammasome subtypes as sources of IL-1β. Read More

View Article and Full-Text PDF

Decline in physical activity in the weeks preceding sustained ventricular arrhythmia in women.

Heart Rhythm O2 2020 Oct 25;1(4):283-287. Epub 2020 Jun 25.

Department of Medicine, Cooper Medical School of Rowan University, Camden, New Jersey.

Background: Heightened risk of cardiac arrest following physical exertion has been reported. Among patients with an implantable defibrillator, an appropriate shock for sustained ventricular arrhythmia was preceded by a retrospective self-report of engaging in mild-to-moderate physical activity. Previous studies evaluating the relationship between activity and sudden cardiac arrest lacked an objective measure of physical activity and women were often underrepresented. Read More

View Article and Full-Text PDF
October 2020

Refining the Approach to Risk Stratification in Patients With Dilated Cardiomyopathy.

J Am Coll Cardiol 2021 Jun;77(23):2906-2908

Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA.

View Article and Full-Text PDF

Improved Risk Stratification for Ventricular Arrhythmias and Sudden Death in Patients With Nonischemic Dilated Cardiomyopathy.

J Am Coll Cardiol 2021 Jun;77(23):2890-2905

Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; Department of Cardiology, North West Heart Centre, Manchester University NHS Foundation Trust, Wythenshawe Campus, Manchester, United Kingdom.

Background: Risk stratification for ventricular arrhythmias (VA) and sudden death in nonischemic dilated cardiomyopathy (DCM) remains suboptimal.

Objectives: The goal of this study was to provide an improved risk stratification algorithm for VA and sudden death in DCM.

Methods: This was a retrospective cohort study of consecutive patients with DCM who underwent cardiac magnetic resonance with late gadolinium enhancement (LGE) at 2 tertiary referral centers. Read More

View Article and Full-Text PDF

Cardiolipin Remodeling by ALCAT1 Links Hypoxia to Coronary Artery Disease by Promoting Mitochondrial Dysfunction.

Mol Ther 2021 Jun 7. Epub 2021 Jun 7.

Barshop Institute for Longevity and Aging Studies, Depart of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, 211166, China. Electronic address:

Cardiolipin is a mitochondrial signature phospholipid that plays a pivotal role in maintaining cardiac health. A loss of tetralinoleoyl cardiolipin (TLCL), the predominant cardiolipin species in the healthy mammalian heart, is implicated in the pathogenesis of coronary heart disease (CHD) through poorly defined mechanisms. Here we identified ALCAT1 as the missing link between hypoxia and CHD in an animal model of myocardial infarction (MI). Read More

View Article and Full-Text PDF

Venoarterial Extracorporeal Membrane Oxygenator Support in Lung Cancer Resection.

Ann Thorac Surg 2021 Jun 7. Epub 2021 Jun 7.

Department of Thoracic Surgery, IRCCS San Raffaele Scientific Institute, Milan, Italy; Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milan, Italy. Electronic address:

Cardiovascular comorbidities often prevent patients with otherwise resectable early-stage lung cancer from undergoing surgery due to prohibitive peri-operative risk. Here we describe the first intraoperative use of venoarterial (VA) ECMO in a stage cIIA lung cancer patient with arterial infiltration and severe post-ischemic dilated cardiomyopathy (EF 23%) undergoing left upper lobectomy with pulmonary artery angioplasty. Providing intra-operative cardiovascular and respiratory function support, VA-ECMO represents a suitable option for patients with heart failure, ensuring adequate hemodynamic profile and reducing the risk of complications. Read More

View Article and Full-Text PDF

A Novel L1 Linker Mutation in DES Resulted in Total Absence of Protein.

J Mol Neurosci 2021 Jun 9. Epub 2021 Jun 9.

Department of Neuropathology, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, 560 029, India.

Desminopathies (MIM*601419) are clinically heterogeneous, manifesting with myopathy and/or cardiomyopathy and with intra-sarcoplasmic desmin-positive deposits. They have either an autosomal dominant (AD) or recessive (AR) pattern of inheritance. Desmin is a crucial intermediate filament protein regulating various cellular functions in muscle cells. Read More

View Article and Full-Text PDF

Multisystemic inflammatory syndrome in children associated with COVID-19: a single center experience in Turkey.

Turk Arch Pediatr 2021 1;56(3):192-199. Epub 2021 May 1.

Division of Cardiology, Department of Pediatrics, Kocaeli University, Kocaeli, Turkey.

Objective: Multisystem inflammatory syndrome in children (MIS-C) associated with the coronavirus disease 2019 (COVID-19) is a new concern emerging as a severe presentation of COVID-19 in children. We aimed to describe the characteristics and short-term outcomes of children diagnosed with MIS-C.

Material And Methods: A retrospective study was conducted on 24 patients who were diagnosed with MIS-C between June 1, 2020 and December 1, 2020. Read More

View Article and Full-Text PDF

Burden of out-of-pocket payments among patients with cardiovascular disease in public and private hospitals in Ibadan, South West, Nigeria: a cross-sectional study.

BMJ Open 2021 06 8;11(6):e044044. Epub 2021 Jun 8.

Health Policy and Management, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan, Nigeria

Objective: Given that the mechanism for financial protection is underdeveloped in Nigeria, out-of-pocket (OOP) payment for treating cardiovascular disease could impose substantial financial burden on individuals and their families. This study estimated the burden of OOP expenditures incurred by a cohort of patients with cardiovascular disease (CVD) in Ibadan, Nigeria.

Design And Settings: This study used a descriptive cross-sectional study design. Read More

View Article and Full-Text PDF

Heart failure due to primary hypothyroidism. Case report and review

Rev Med Inst Mex Seguro Soc 2020 04 13;58(2):206-211. Epub 2020 Apr 13.

Hospital Militar Central, Unidad de Insuficiencia Cardiaca, Servicio de Cardiología, Buenos Aires, Argentina.

Background: There are well-recognized relationships between thyroid hormones, heart and peripheral vascular system. Thyroid hormones have relevant actions on the heart and circulation, generate multiple effects including hemodynamic changes and exert mediated effects on cardiac cells through gene expression.

Clinical Case: We present a 64-year-old woman with diagnosis of dilated cardiomyopathy with reduced ejection fraction, in whom coronary disease was thought of as the most probable etiology by clinical antecedents but in the evolution, other possible etiologies were to appear. Read More

View Article and Full-Text PDF

Single-cell transcriptomic analyses of cardiac immune cells reveal that Rel-driven CD72-positive macrophages induce cardiomyocyte injury.

Cardiovasc Res 2021 Jun 8. Epub 2021 Jun 8.

The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510407, China.

Aims: The goal of our study was to investigate the heterogeneity of cardiac macrophages (CMφs) in mice with transverse aortic constriction (TAC) via single-cell sequencing and identify a subset of macrophages associated with heart injury.

Methods And Results: We selected all CMφs from CD45+ cells using single-cell mRNA sequencing data. Through dimension reduction, clustering and enrichment analyses, CD72hi CMφs were identified as a subset of proinflammatory macrophages. Read More

View Article and Full-Text PDF

Left ventricular noncompaction-a rare cause of triad: heart failure, ventricular arrhythmias, and systemic embolic events: a case report.

J Med Case Rep 2021 Jun 8;15(1):316. Epub 2021 Jun 8.

Faculty of Medicine- Physiology Department, The University of Medicine and Pharmacy Craiova, Craiova, Romania.

Background: Left ventricular noncompaction is a rare cardiomyopathy characterized by a thin, compacted epicardial layer and a noncompacted endocardial layer, with trabeculations and recesses that communicate with the left ventricular cavity. In the advanced stage of the disease, the classical triad of heart failure, ventricular arrhythmia, and systemic embolization is common. Segments involved are the apex and mid inferior and lateral walls. Read More

View Article and Full-Text PDF

The multifaceted view of heart problem in Duchenne muscular dystrophy.

Cell Mol Life Sci 2021 Jun 6. Epub 2021 Jun 6.

Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.

Dystrophin is a large protein serving as local scaffolding repetitively bridging cytoskeleton and the outside of striated muscle cell. As such dystrophin is a critical brick primarily in dystrophin-associated protein complex (DAGC) and in a larger submembranous unit, costamere. Accordingly, the lack of functional dystrophin laying at the root of Duchenne muscular dystrophy (DMD) drives sarcolemma instability. Read More

View Article and Full-Text PDF

Predicting inappropriate S-ICD® episodes by simple 12-lead surface ECG parameters.

J Electrocardiol 2021 May 27;67:89-93. Epub 2021 May 27.

Department of Cardiology II - Electrophysiology, University Hospital Muenster, Muenster, Germany. Electronic address:

Aims: The present study aims at analyzing the role of a preimplantation 12-lead electrocardiogram (ECG) on the prediction of inappropriate S-ICD® episodes.

Methods: N=116 screened patients (pts) with an S-ICD® and a follow-up of at least 6 months were included. A preimplantation 12-lead ECG (50 mm/s, 10 mm/mV) was analyzed with regard to QRS and T-wave amplitude, T wave concordance or discordance and QRS/T wave ratio in all 12 leads. Read More

View Article and Full-Text PDF

Left ventricular global longitudinal strain predicts elevated cardiac pressures and poor clinical outcomes in patients with non-ischemic dilated cardiomyopathy.

Cardiovasc Ultrasound 2021 Jun 5;19(1):21. Epub 2021 Jun 5.

Department of Pathology, Forensic Medicine and Pharmacology, Institute of Biomedical Science, Faculty of Medicine, Vilnius University, M. K. Čiurlionio 21, 03101, Vilnius, Lithuania.

Background: Risk stratification in patients with non-ischemic dilated cardiomyopathy (NI-DCM) is essential to treatment planning. Global longitudinal strain (GLS) predicts poor prognosis in various cardiac diseases, but it has not been evaluated in a cohort of exclusively NI-DCM. Although deformation parameters have been shown to reflect diastolic function, their association with other hemodynamic parameters needs further elucidation. Read More

View Article and Full-Text PDF

Disorganization of intercalated discs in dilated cardiomyopathy.

Sci Rep 2021 Jun 4;11(1):11852. Epub 2021 Jun 4.

Department of Cellular and Organ Pathology, Graduate School of Medicine, Akita University, 1-1-1 Hondo, Akita, Akita, 010-8543, Japan.

Dilated cardiomyopathy (DCM) is a primary myocardial disease, the pathology of which is left ventricular or biventricular dilation and impaired myocardial contractility. The clinical and pathological diagnosis of DCM is difficult, and other cardiac diseases must be ruled out. Several studies have reported pathological findings that are characteristic of DCM, including cardiomyocyte atrophy, nuclear pleomorphism, and interstitial fibrosis, but none of these findings are DCM-specific. Read More

View Article and Full-Text PDF

Generation of a heterozygous FLNC mutation-carrying human iPSC line, USFi002-A, for modeling dilated cardiomyopathy.

Stem Cell Res 2021 May 12;53:102394. Epub 2021 May 12.

Heart Institute, Morsani College of Medicine, University of South Florida, Tampa FL, USA. Electronic address:

Dilated Cardiomyopathy (DCM) is one of the main causes of sudden cardiac death and heart failure and is the leading indication for cardiac transplantation worldwide. Mutations in different genes including TTN, MYH7, and LMNA, have been linked to the development of DCM. Here, we generated a human induced pluripotent stem cell (IPSC) line from a DCM patient with a familial history that carries a frameshift mutation in Filamin C (FLNC). Read More

View Article and Full-Text PDF

Generation and characterization of three human induced pluripotent stem cell lines (iPSC) from two family members with dilated cardiomyopathy and left ventricular noncompaction (DCM-LVNC) and one healthy heterozygote sibling.

Stem Cell Res 2021 May 5;53:102382. Epub 2021 May 5.

The Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Faculty of Engineering Sciences, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel; The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel; Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel. Electronic address:

Autophagy serves as a master regulator of cellular homeostasis. Hence, expectedly autophagic dysfunction has been documented in many diseases such as cancer, neurodegeneration and cardiovascular disorders. A novel homozygous mutation in PLEKHM2 gene (mPLEKHM2) resulted in dilated cardiomyopathy with left ventricular noncompaction (DCM-LVNC), probably as result of impaired autophagy due to disruption of lysosomal movement assisted by PLEKHM2. Read More

View Article and Full-Text PDF

Heavy alcohol drinking and subclinical echocardiographic abnormalities of structure and function.

Open Heart 2021 Jun;8(1)

Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.

Objective: The aim of the study is to assess changes in heart structure and function associated with heavy alcohol use by comparing echocardiographic indices in a population-based sample to those in patients admitted to an inpatient facility with severe alcohol problems.

Methods And Results: We used data from the Know Your Heart study (2015-2017) which is a cross-sectional study that recruited 2479 participants aged 35-69 years from the general population of the city of Arkhangelsk in Northwest Russia and 278 patients from the Arkhangelsk Regional Psychiatric Hospital with a primary diagnosis related to chronic alcohol use (narcology clinic subsample). The drinking patterns of the population-based sample were characterised in detail. Read More

View Article and Full-Text PDF