23,381 results match your criteria Dilated Cardiomyopathy


Characterization of dendritic cells in human and experimental myocarditis.

ESC Heart Fail 2020 Jul 3. Epub 2020 Jul 3.

Department of Internal Medicine I, Division of Cardiology, University Hospital Jena, Jena, Germany.

Aims: Dendritic cells (DCs) are central mediators of adaptive immunity, and there is growing evidence of their role in myocardial inflammatory disease. We hypothesized that plasmacytoid and myeloid DCs are involved in the mechanisms of myocarditis and analysed these two main subtypes in human myocarditis subjects, as well as in a murine model of experimental autoimmune myocarditis (EAM).

Methods And Results: Circulating DCs were analysed by flow cytometry in patients with acute myocarditis, dilated cardiomyopathy, and controls. Read More

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http://dx.doi.org/10.1002/ehf2.12767DOI Listing

Dilated Cardiomyopathy Mutations in Thin Filament Regulatory Proteins Reduce Contractility, Suppress Systolic Ca & Activate NFAT & AKT Signalling.

Am J Physiol Heart Circ Physiol 2020 Jul 3. Epub 2020 Jul 3.

Radcliffe Department of Medicine (Division of Cardiovascular Medicine), University of Oxford, United Kingdom.

Dilated cardiomyopathy (DCM) is clinically characterised by dilated ventricular cavities and reduced ejection fraction, leading to heart failure and increased thromboembolic risk. Mutations in thin filament regulatory proteins can cause DCM and have been shown in vitro to reduce contractility and myofilament Ca-affinity. In this work we have studied the functional consequences of mutations in cardiac troponin T (R131W), cardiac troponin I (K36Q) and α-tropomyosin (E40K) using adenovirally transduced isolated guinea pig left ventricular cardiomyocytes. Read More

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http://dx.doi.org/10.1152/ajpheart.00272.2020DOI Listing

Left ventricular reverse remodeling after successful subannular mitral valve repair in end-stage heart failure: a case report.

Eur Heart J Case Rep 2020 Jun 27;4(3):1-5. Epub 2020 Apr 27.

Department of Cardiovascular Surgery, University Heart and Vascular Center Hamburg, Martinistraße 52, D-20246 Hamburg, Germany.

Background: Due to ongoing left ventricular (LV) remodeling and consecutive geometric displacement of both papillary muscles, end-stage heart failure is frequently associated with relevant functional mitral regurgitation (FMR) Type IIIb. Treatment strategies of FMR and their prognostic impact are still controversial.

Case Summary: We present a case of an 80-year-old patient who suffered from recurrent symptoms of congestive heart failure due to dilated cardiomyopathy and concomitant severe FMR. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319855PMC

Pseudoaneurysm rupture presenting as bleeding from the cannulation site in a paediatric patient with dilated cardiomyopathy and congenital skin lesions requiring EXCOR Paediatric ventricular assist device: a case report.

Eur Heart J Case Rep 2020 Jun 15;4(3):1-6. Epub 2020 May 15.

Department of Cardiovascular Surgery, Shizuoka Children's Hospital, 860 Urushiyama, Aoiku, Shizuoka City, Shizuoka 420-8660, Japan.

Background: EXCOR Paediatric is used worldwide as a bridge-to-transplant treatment. It provides improved patient stability during the waiting period compared with previous ventricular assist device (VAD). However, investigations into complications which may occur among the paediatric population during long waiting periods are still sparse. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319848PMC

Case report: adult-onset manifesting heterozygous glycogen storage disease type IV with dilated cardiomyopathy and absent late gadolinium enhancement on cardiac magnetic resonance imaging.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-6. Epub 2020 May 3.

Department of Radiology, Jacobi Medical Center, 1400 Pelham Pkwy S, Bronx, NY 10461, USA.

Background: Glycogen storage disease type IV (GSD IV; Andersen's disease) is a rare autosomal recessive disease caused by mutation in the GBE1 gene. Presentation of GSD IV varies on a continuum of severity and symptomatology ranging from neonatal death to mild adult-onset disease with variable involvement of hepatic, muscular, neurologic, dermatologic, and cardiac systems. Cardiomyopathy seen in GSD IV is also heterogeneous and its appearance on cardiac magnetic resonance imaging (CMR) is rarely described. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319828PMC

Epigenetic-sensitive liquid biomarkers and personalised therapy in advanced heart failure: a focus on cell-free DNA and microRNAs.

J Clin Pathol 2020 Jul 2. Epub 2020 Jul 2.

Clinical Department of Internal Medicine and Specialistics, Department of Advanced Medical and Surgical Sciences (DAMSS), University of Campania "Luigi Vanvitelli", Naples, Italy.

Dilated cardiomyopathy (DCM) represents a common genetic cause of mechanical and/or electrical dysfunction leading to heart failure (HF) onset for which truncating variants in titin (TTN) gene result in the most frequent mutations. Moreover, myocyte and endothelial cell apoptosis is a key endophenotype underlying cardiac remodelling. Therefore, a deeper knowledge about molecular networks leading to acute injury and apoptosis may reveal novel circulating biomarkers useful to better discriminate HF phenotypes, patients at risk of heart transplant as well as graft reject in order to improve personalised therapy. Read More

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http://dx.doi.org/10.1136/jclinpath-2019-206404DOI Listing

Risk predictors in a Spanish cohort with cardiac laminopathies. The REDLAMINA registry.

Rev Esp Cardiol (Engl Ed) 2020 Jun 29. Epub 2020 Jun 29.

Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain; Departamento de Cardiología, Health in Code, A Coruña, Spain.

Introduction And Objectives: According to sudden cardiac death guidelines, an implantable cardioverter-defibrillator (ICD) should be considered in patients with LMNA-related dilated cardiomyopathy (DCM) and ≥ 2 risk factors: male sex, left ventricular ejection fraction (LVEF) <45%, nonsustained ventricular tachycardia (NSVT), and nonmissense genetic variants. In this study we aimed to describe the clinical characteristics of carriers of LMNA genetic variants among individuals from a Spanish cardiac-laminopathies cohort (REDLAMINA registry) and to assess previously reported risk criteria.

Methods: The relationship between risk factors and cardiovascular events was evaluated in a cohort of 140 carriers (age ≥ 16 years) of pathogenic LMNA variants (54 probands, 86 relatives). Read More

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http://dx.doi.org/10.1016/j.rec.2020.03.026DOI Listing

Commentary: Searching for simpler parameters in the context of non-ischemic dilated cardiomyopathy.

Semin Thorac Cardiovasc Surg 2020 Jun 29. Epub 2020 Jun 29.

Cardiac Surgery Unit, Parma General Hospital, Department of Medicine and Surgery, University of Parma, Italy. Electronic address:

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http://dx.doi.org/10.1053/j.semtcvs.2020.06.035DOI Listing

Viral myocarditis involves the generation of autoreactive T cells with multiple antigen specificities that localize in lymphoid and non-lymphoid organs in the mouse model of CVB3 infection.

Mol Immunol 2020 Jun 29;124:218-228. Epub 2020 Jun 29.

School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA. Electronic address:

Autoreactive T cells may contribute to post-viral myocarditis induced with Coxsackievirus B3 (CVB3), but the underlying mechanisms of their generation are unclear. Here, we have comprehensively analyzed the generation of antigen-specific, autoreactive T cells in the mouse model of CVB3 infection for antigens implicated in patients with myocarditis/dilated cardiomyopathy. First, comparative analysis of CVB3 proteome with five autoantigens led us to identify three mimicry epitopes, one each from adenine nucleotide translocator 1 (ANT), sarcoplasmic/endoplasmic reticulum Ca ATPase 2a (SERCA2a) and cardiac troponin I. Read More

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http://dx.doi.org/10.1016/j.molimm.2020.06.017DOI Listing

Young patients with heart failure - clinical characteristics and outcomes. Data from the Swedish Heart Failure, National Patient, Population and Cause of Death Registers.

Eur J Heart Fail 2020 Jul 2. Epub 2020 Jul 2.

Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Aims: The prevalence and hospitalizations of patients with heart failure (HF) aged <55 years have increased in Sweden during the last decades. We aimed to compare characteristics of younger and older patients with HF, and examine survival in patients <55 years compared with matched controls.

Methods And Results: All patients >18 years in the Swedish Heart Failure Register from 2003 to 2014 were included. Read More

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http://dx.doi.org/10.1002/ejhf.1952DOI Listing

Left Bundle Pacing for Left Bundle Branch Block and Intermittent Third-Degree Atrioventricular Block in a Mutation-Related Hypertrophic Cardiomyopathy With Restrictive Phenotype in a Child.

Front Pediatr 2020 16;8:312. Epub 2020 Jun 16.

Department of Cardiology, Children's Hospital of Nanjing Medical University, Nanjing, China.

Hypertrophic cardiomyopathy (HCM) is a group of myocardial diseases defined by cardiac hypertrophy which cannot be explained by secondary causes with a non-dilated left ventricle and preserved or increased ejection fraction. Sometimes it can be combined with restrictive cardiomyopathy. Here we describe a very rare case of a 12-year-old girl with non-obstructive hypertrophic cardiomyopathy accompanied by restrictive phenotype, complete left bundle branch block and intermittent third-degree atrioventricular block, who presented with recurrent syncope. Read More

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http://dx.doi.org/10.3389/fped.2020.00312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308432PMC

Reversible Cardiovocal (Ortner's) Syndrome in Dilated Cardiomyopathy - A Rare Presentation of a Common Disease.

J Assoc Physicians India 2020 Jun;68(6):65-66

Resident, Sri Venkateswara Medical College and Research Institute- Pondicherry.

Ortners syndrome is a rare cause of recurrent laryngeal nerve palsy due to cardiac causes. After the description of this syndrome by Ortner in patients with mitral stenosis, it was described by many authors in multiple other cardiac conditions. Here we present a case of Ortner's syndrome in Dilated cardiomyopathy,which reverted completely after medical management of DCMP. Read More

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Myotonic dystrophy type 1 and high ventricular vulnerability at the electrophysiological evaluation: ICD yes or not?

Acta Myol 2020 Mar 1;39(1):32-35. Epub 2020 Mar 1.

Department of Cardiac Electrophysiology and Pacing, Istituto Clinico Sant'Ambrogio, Milan, Italy.

A significant number of sudden death (SD) is observed in myotonic dystrophy (DM1) despite pacemaker implantation and some consider the ICD to be the preferential device in patients with conduction disease. According to the latest guidelines, prophylactic ICD implantation in patients with neuromuscular disorder should follow the same recommendations of non-ischemic dilated cardiomyopathy, being reasonable when pacing is needed. We here report a case of DM1 patient who underwent ICD implantation even in the absence of conduction disturbances on ECG and ventricular dysfunction/fibrosis at cardiac magnetic resonance. Read More

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http://dx.doi.org/10.36185/2532-1900-006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315899PMC

Transplanted stents: a case report.

BMC Cardiovasc Disord 2020 Jun 30;20(1):312. Epub 2020 Jun 30.

Department of Cardiac Surgery, Medical University Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Background: An optimal donor work-up to exclude preexisting conditions is recommended, but urgency and technical equipment in donor centers must be considered. We report a case of two coronary stents present in the donor heart and the related long-term outcome.

Case Presentation: A 59-year-old European male patient suffering from dilated cardiomyopathy with severely reduced left ventricular function and presenting with NYHA III underwent cardiac transplantation in 2004. Read More

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http://dx.doi.org/10.1186/s12872-020-01597-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325242PMC

Prognostic value of free triiodothyronine in patients with dilated cardiomyopathy.

Chin Med J (Engl) 2020 Jun 26. Epub 2020 Jun 26.

Section of Pacing and Electrophysiology, Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.

Background: The association between free triiodothyronine (FT3) and long-term prognosis in dilated cardiomyopathy (DCM) patients has not been evaluated. The purpose of this study was to determine whether the level of FT3 could provide prognostic value in patients with DCM.

Methods: Data of consecutive patients diagnosed with DCM were collected from October 2009 to December 2014. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000896DOI Listing

Gain of Function Variants in Dilated Cardiomyopathy.

Circ Genom Precis Med 2020 Jun 30. Epub 2020 Jun 30.

Dorothy M. Davis Heart and Lung Research Institute & Divisions of Human Genetics & Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH.

- Dilated cardiomyopathy (DCM) is a genetically heterogeneous cardiac disease characterized by progressive ventricular enlargement and reduced systolic function. Here, we report genetic and functional analyses implicating the RAS signaling protein, SOS1, in DCM pathogenesis. - Exome sequencing was performed on 412 probands and family members from our DCM cohort, identifying several variants with potential disease involvement. Read More

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http://dx.doi.org/10.1161/CIRCGEN.119.002892DOI Listing

BET bromodomain proteins regulate transcriptional reprogramming in genetic dilated cardiomyopathy.

JCI Insight 2020 Jun 30. Epub 2020 Jun 30.

Department of Medicine, Emory University School of Medicine, Atlanta, United States of America.

The bromodomain and extraterminal (BET) family of epigenetic reader proteins are key regulators of inflammatory and hypertrophic gene expression in the heart. We previously identified the activation of pro-inflammatory gene networks as a key early driver of dilated cardiomyopathy (DCM) in transgenic mice expressing a mutant form of phospholamban (PLNR9C) - a genetic cause of DCM in humans. We hypothesized that BETs coactivate this inflammatory process, representing a critical node in the progression of DCM. Read More

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http://dx.doi.org/10.1172/jci.insight.138687DOI Listing

Left ventricular midwall fibrosis as a predictor of sudden cardiac death in non-ischaemic dilated cardiomyopathy: a meta-analysis.

ESC Heart Fail 2020 Jun 30. Epub 2020 Jun 30.

Department of Cardiology, West China Hospital, Sichuan University, Guoxue Xiang No. 37, Chengdu, Sichuan, 610041, China.

Identification of patients with non-ischaemic dilated cardiomyopathy (NICM) who are at risk of sudden cardiac death (SCD) and could benefit from an implantable cardioverter defibrillator (ICD) is challenging. The study aims to systematically assess the prognostic value of left ventricular (LV) midwall late gadolinium enhancement (LGE) pattern in patients with NICM and further explore its value on predicting SCD events. The study was prospectively registered in PROPSERO (CRD42019138468). Read More

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http://dx.doi.org/10.1002/ehf2.12865DOI Listing

Cardiorenal Amyloidosis.

J Assoc Physicians India 2020 Jul;68(7):74-76

Senior Resident, Family Medicine, Max Superspeciality Hospital, Saket, New Delhi.

Amyloidosis is a conglomeration of diseases due to production and deposition of amyloid, a proteinaceous substance, into organs, tissues, nerves and other places in the body affecting their normal function. This case report is of a 65 year old gentleman, resident of Bihar admitted with a short history of two months. He came with chief complaints of swelling in both lower limbs associated with heaviness in legs, shortness of breath, dizziness, fatigue and passage of frothy urine for two months. Read More

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A Korean child diagnosed with malonic aciduria harboring a novel start codon mutation following presentation with dilated cardiomyopathy.

Mol Genet Genomic Med 2020 Jun 30:e1379. Epub 2020 Jun 30.

Department of Laboratory Medicine, Kyung Hee University School of Medicine, Seoul, Korea.

Background: Malonic aciduria (MA, OMIM#248360) is an extremely rare inherited metabolic disorder caused by the deficiency of malonyl-CoA decarboxylase. The phenotype exhibited by patients with MA is variable, but may include symptoms, such as developmental delay in early childhood, seizures, vomiting, metabolic acidosis, hypoglycemia, ketosis, and cardiomyopathy. We describe the first case of a Korean child with MA who presented with dilated cardiomyopathy (DCMP) at the age of 3 months. Read More

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http://dx.doi.org/10.1002/mgg3.1379DOI Listing

Practice makes perfect: improved long-term survival in nonischaemic dilated cardiomyopathy with contemporary treatment.

Eur J Heart Fail 2020 Jun 29. Epub 2020 Jun 29.

Department of Cardiology, Clinical Centre of Serbia, Belgrade, Serbia.

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http://dx.doi.org/10.1002/ejhf.1950DOI Listing

An Increased Burden of Ion Channel Gene Variants Is Related to Distinct Phenotypes in Pediatric Patients with Left Ventricular Noncompaction.

Circ Genom Precis Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Pediatrics, University of Toyama, Toyama, Japan.

- Left ventricular noncompaction (LVNC) is a hereditary type of cardiomyopathy. Although it is associated with high morbidity and mortality, the related ion channel gene variants in children have not been fully investigated. This study aimed to elucidate the ion channel genetic landscape of LVNC and identify genotype-phenotype correlations in a large Japanese cohort. Read More

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http://dx.doi.org/10.1161/CIRCGEN.119.002940DOI Listing

Relationship between malnutrition and coronary microvascular dysfunction in patients with nonischemic dilated cardiomyopathy.

Turk J Med Sci 2020 Jun 30. Epub 2020 Jun 30.

Background/ aim: Malnutrition is common in patients with nonischemic dilated cardiomyopathy (DCM), especially in the end-stages of the disease where heart failure symptoms predominate. Malnutrition has been associated with atherosclerosis in patients with chronic kidney disease, but it is unknown whether a similar relationship exist between malnutrition and coronary microvascular dysfunction (CMD). In the present study, we aimed to analyze whether indices of malnutrition were associated with coronary flow reserve (CFR) in patients with DCM. Read More

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http://dx.doi.org/10.3906/sag-2003-239DOI Listing

Bipolar radiofrequency ablation for ventricular tachycardias originating from the interventricular septum: safety and efficacy in a pilot cohort study.

Heart Rhythm 2020 Jun 26. Epub 2020 Jun 26.

Department of Arrhythmology and Cardiac Electrophysiology, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Background: Interest has grown in recent years for bipolar radiofrequency ablation (B-RFA). However, indications and outcome in patients with ventricular tachycardia (VT) are still to be defined.

Objective: To describe patient selection, safety and effectiveness of B-RFA, in a pilot cohort study of patients with nonischemic dilated cardiomyopathy (NIDCM) and drug-refractory VT. Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.06.025DOI Listing
June 2020
5.076 Impact Factor

[Full - transcriptome analysis of miRNA expression in mononuclear cells in patients with acute decompensation of chronic heart failure of various etiologies].

Ter Arkh 2019 Sep 15;91(9):62-67. Epub 2019 Sep 15.

Myasnikov Institute of Clinical Cardiology, National Medical Research Center of Cardiology.

It is known that micro RNAs are an important regulatory element in the pathogenesis of many diseases, including cardiovascular diseases. Different levels of expression of these molecules in various pathologies makes miRNA a potential diagnostic and prognostic biomarker.

Aim: Analysis of miRNA expression levels in mononuclear blood cells (MBC) of patients with acute decompensation f chronic heart failure (CHF) of various etiologies and evaluation of the possibility of their use as a biological marker. Read More

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http://dx.doi.org/10.26442/00403660.2019.09.000294DOI Listing
September 2019

Association of S100B 3'UTR polymorphism with risk of chronic heart failure in a Chinese Han population.

Medicine (Baltimore) 2020 Jun;99(26):e21018

Department of Cardiovascular Medicine.

To study the correlation between single nucleotide polymorphism (SNP) of the 3' untranslated region (UTR) rs9722 locus in S100B and the risk of chronic heart failure (CHF), plasma levels of S100B protein as well as has-miR-340-3p in a Chinese Han population.A total of 215 patients with CHF (124 ischemic cardiomyopathy (ICM) and 91 dilated cardiomyopathy (DCM)) and 215 healthy controls were recruited to analyze the S100B rs9722 genotype by Sanger sequencing. The levels of hsa-miR-340-3p in the plasma were detected by RT-PCR, and S100B levels were detected by ELISA. Read More

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http://dx.doi.org/10.1097/MD.0000000000021018DOI Listing

Correlation Between Arrhythmia and the Prognosis in Children With EFE/LVNC/DCM.

Front Pediatr 2020 10;8:280. Epub 2020 Jun 10.

Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang, China.

To explore the correlation between different phenotypes of arrhythmia and the prognosis in children with EFE/LVNC/DCM. A total of 167 children with cardiomyopathy diagnosed and treated in Shengjing Hospital between January 2010 and May 2019 were evaluated. After patient screening, 31 patients with endomyocardial fibroelastosis (EFE), left ventricular non-compaction, or dilated cardiomyopathy with significant arrhythmias were selected. Read More

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http://dx.doi.org/10.3389/fped.2020.00280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297920PMC

Hypochlorhydria reduces mortality in heart failure caused by Kcne2 gene deletion.

FASEB J 2020 Jun 25. Epub 2020 Jun 25.

Experimental and Clinical Research Center, Berlin, Germany.

Heart failure (HF) is an increasing global health crisis, affecting 40 million people and causing 50% mortality within 5 years of diagnosis. A fuller understanding of the genetic and environmental factors underlying HF, and novel therapeutic approaches to address it, are urgently warranted. Here, we discovered that cardiac-specific germline deletion in mice of potassium channel β subunit-encoding Kcne2 (Kcne2 ) causes dilated cardiomyopathy and terminal HF (median longevity, 28 weeks). Read More

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http://dx.doi.org/10.1096/fj.202000013RRDOI Listing

Hypertrophic and Dilated Cardiomyopathy-Associated Troponin T Mutations R130C and ΔK210 Oppositely Affect Length-Dependent Calcium Sensitivity of Force Generation.

Front Physiol 2020 3;11:516. Epub 2020 Jun 3.

Institute of Vegetative Physiology, University of Cologne, Cologne, Germany.

Length-dependent activation of calcium-dependent myocardial force generation provides the basis for the Frank-Starling mechanism. To directly compare the effects of mutations associated with hypertrophic cardiomyopathy and dilated cardiomyopathy, the native troponin complex in skinned trabecular fibers of guinea pigs was exchanged with recombinant heterotrimeric, human, cardiac troponin complexes containing different human cardiac troponin T subunits (hcTnT): hypertrophic cardiomyopathy-associated hcTnT, dilated cardiomyopathy-associated hcTnT or the wild type hcTnT (hcTnT) serving as control. Force-calcium relations of exchanged fibers were explored at short fiber length defined as 110% of slack length () and long fiber length defined as 125% of (1. Read More

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http://dx.doi.org/10.3389/fphys.2020.00516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283609PMC

The association of hematological indices with the response to cardiac resynchronization therapy: a single-center study.

Hippokratia 2019 Jul-Sep;23(3):118-125

Second Department of Cardiology; Michaelidion Cardiac Center, University of Ioannina, Ioannina, Greece.

Background: Cardiac resynchronization therapy (CRT) is an established therapeutic option for patients with heart failure (HF) and left ventricular ejection fraction (LVEF) ≤35 % who meet specific criteria according to current guidelines. However, up to 40 % of patients have no response to CRT. Our study aimed to investigate the association between different hematological and biochemical indices and response to CRT. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307505PMC

Identification of Target Genes and Transcription Factors in Mice with LMNA-Related Dilated Cardiomyopathy by Integrated Bioinformatic Analyses.

Med Sci Monit 2020 Jun 14;26:e924576. Epub 2020 Jun 14.

Department of Cardiovascular Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China (mainland).

BACKGROUND Dilated cardiomyopathy (DCM), which is characterized by enlarged ventricular dimensions and systolic dysfunction, is the most common type of cardiomyopathy. Mutations in the LMNA gene are reported in approximately 10% of familial DCM cases. However, the mechanism of LMNA mutations in human DCM remains unclear. Read More

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http://dx.doi.org/10.12659/MSM.924576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313426PMC

Clinical outcomes after primary prevention defibrillator implantation are better predicted when the left ventricular ejection fraction is assessed by cardiovascular magnetic resonance.

J Cardiovasc Magn Reson 2020 Jun 25;22(1):48. Epub 2020 Jun 25.

Service de Cardiologie, EA4650 (Signalisation, électrophysiologie et imagerie des lésions d'ischémie-reperfusion myocardique), Normandie Univ, UNICAEN, CHU de Caen Normandie, 14000, Caen, France.

Background: The left ventricular ejection fraction (LVEF) is the key selection criterion for an implanted cardioverter defibrillator (ICD) in primary prevention of sudden cardiac death. LVEF is usually assessed by two-dimensional echocardiography, but cardiovascular magnetic resonance (CMR) imaging is increasingly used. The aim of our study was to evaluate whether LVEF assessment using CMR imaging (CMR-LVEF) or two-dimensional echocardiography (2D echo-LVEF) may predict differently the occurrence of clinical outcomes. Read More

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http://dx.doi.org/10.1186/s12968-020-00640-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315498PMC

Nanoscale regulation of L-type calcium channels differentiates between ischemic and dilated cardiomyopathies.

EBioMedicine 2020 Jun 21;57:102845. Epub 2020 Jun 21.

Department of Cardiovascular Sciences, Imperial Centre for Translational and Experimental Medicine, National Heart and Lung Institute, Imperial College London, London W120NN, UK. Electronic address:

Background: Subcellular localization and function of L-type calcium channels (LTCCs) play an important role in regulating contraction of cardiomyocytes. Understanding how this is affected by the disruption of transverse tubules during heart failure could lead to new insights into the disease.

Methods: Cardiomyocytes were isolated from healthy donor hearts, as well as from patients with cardiomyopathies and with left ventricular assist devices. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317229PMC

Biventricular Thrombi in Substance-Induced Dilated Cardiomyopathy.

CASE (Phila) 2020 Jun 20;4(3):170-174. Epub 2020 Feb 20.

Department of Cardiology, Gundersen Health System, La Crosse, Wisconsin.

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http://dx.doi.org/10.1016/j.case.2020.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303235PMC

Liver-Specific siRNA-Mediated Stat3 or C3 Knockdown Improves the Outcome of Experimental Autoimmune Myocarditis.

Mol Ther Methods Clin Dev 2020 Sep 22;18:62-72. Epub 2020 May 22.

Department of Molecular Biotechnology and Health Science, University of Torino, Via Nizza 52, Torino 10126, Italy.

Myocarditis can lead to autoimmune disease, dilated cardiomyopathy, and heart failure, which is modeled in the mouse by cardiac myosin immunization (experimental autoimmune myocarditis [EAM]). Signal transducer and activator of transcription 3 (STAT3) systemic inhibition exerts both preventive and therapeutic effects in EAM, and STAT3 constitutive activation elicits immune-mediated myocarditis dependent on complement C3 and correlating with activation of the STAT3-interleukin 6 (IL-6) axis in the liver. Thus, liver-specific STAT3 inhibition may represent a therapeutic option, allowing to bypass the heart toxicity, predicted by systemic STAT3 inhibition. Read More

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http://dx.doi.org/10.1016/j.omtm.2020.05.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301178PMC
September 2020

Clinical, pathological, imaging, and genetic characterization in a Taiwanese cohort with limb-girdle muscular dystrophy.

Orphanet J Rare Dis 2020 Jun 23;15(1):160. Epub 2020 Jun 23.

Baylor Genetics, Houston, TX, USA.

Background: Limb-girdle muscular dystrophy (LGMD) is a genetically heterogeneous, hereditary disease characterized by limb-girdle weakness and histologically dystrophic changes. The prevalence of each subtype of LGMD varies among different ethnic populations. This study for the first time analyzed the phenotypes and genotypes in Taiwanese patients with LGMD in a referral center for neuromuscular diseases (NMDs). Read More

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http://dx.doi.org/10.1186/s13023-020-01445-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310488PMC

CFTR deficiency causes cardiac dysplasia during zebrafish embryogenesis and is associated with dilated cardiomyopathy.

Mech Dev 2020 Jun 20:103627. Epub 2020 Jun 20.

SCU-CUHK Joint Laboratory for Reproductive Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, People's Republic of China. Electronic address:

Mutations in the CFTR gene cause cystic fibrosis (CF) with myocardial dysfunction. However, it remains unknown whether CF-related heart disease is a secondary effect of pulmonary disease, or an intrinsic primary defect in the heart. Here, we used zebrafish, which lack lung tissue, to investigate the role of CFTR in cardiogenesis. Read More

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http://dx.doi.org/10.1016/j.mod.2020.103627DOI Listing

Cushing syndrome cardiomyopathy: an unusual manifestation of small-cell lung cancer.

ESC Heart Fail 2020 Jun 23. Epub 2020 Jun 23.

Department of Medicine, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT, 06030-2202, USA.

Cushing syndrome is a rare cause of dilated cardiomyopathy and heart failure with reduced ejection fraction. Cases describing this association are scarce. We describe a patient presenting with acute heart failure, new cardiomyopathy, refractory hypokalaemia, severe hyperglycaemia, and uncontrolled hypertension who was found to have hypercortisolism secondary to an ectopic adrenocorticotropic hormone-secreting primary lung neoplasm. Read More

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http://dx.doi.org/10.1002/ehf2.12860DOI Listing

Cardiac hypertrophic risk markers of left ventricle and left atrium in chronic heart failure due to aortic and mitral valve disease.

Acta Radiol 2020 Jun 22:284185120933530. Epub 2020 Jun 22.

Faculty of Biological Sciences, Department of Biochemistry, Quaid-I-Azam University, Islamabad, Pakistan.

Background: Chronic valvular heart disease leads to systolic dysfunction and left atrial enlargement that ultimately results in heart failure.

Purpose: To investigate prognostic importance of Echocardiography and plasma natriuretic peptide levels that increase as a compensatory response and can be used as predictive markers for cardiac hypertrophy.

Material And Methods: The patients were divided into three groups: 51 with left ventricle hypertrophy due to aortic valve disease; 126 with left atrial enlargement due to mitral valve dysfunction; and 76 with both conditions. Read More

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http://dx.doi.org/10.1177/0284185120933530DOI Listing

Prevalence and prognostic relevance of myocardial inflammation and cardiotropic viruses in non-ischemic dilated cardiomyopathy.

Cardiol J 2020 Jun 22. Epub 2020 Jun 22.

Department of Pathology, Forensic Medicine and Pharmacology, Faculty of Medicine, Vilnius University, M. K. Ciurlionio 21, LT-03101 Vilnius, Lithuania.

Background: Non-ischemic dilated cardiomyopathy (DCM) is a heterogeneous disease with a spectrum of etiological factors. However, subsets of the disease are not well-characterized with respect to these factors. The aim of this study was to evaluate the prevalence of myocardial inflammation and cardiotropic viruses in DCM patients and their impact on clinical outcome. Read More

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http://dx.doi.org/10.5603/CJ.a2020.0088DOI Listing

Alterations of the renin angiotensin system in human end-stage heart failure before and after mechanical cardiac unloading by LVAD support.

Mol Cell Biochem 2020 Jun 20. Epub 2020 Jun 20.

Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.

Heart transplantation is often an unrealizable therapeutic option for end-stage heart failure, which is why mechanical left ventricular assist devices (LVADs) become an increasingly important therapeutic alternative. Currently, there is a lack of information about molecular mechanisms which are influenced by LVADs, particularly regarding the pathophysiologically critical renin angiotensin system (RAS). We, therefore, determined regulation patterns of key components of the RAS and the β-arrestin signaling pathways in left ventricular (LV) tissue specimens from 8 patients with end-stage ischemic cardiomyopathy (ICM) and 12 patients with terminal dilated cardiomyopathy (DCM) before and after LVAD implantation and compared them with non-failing (NF) left ventricular tissue samples: AT1R, AT2R, ACE, ACE2, MasR, and ADAM17 were analyzed by polymerase chain reaction. Read More

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http://dx.doi.org/10.1007/s11010-020-03787-7DOI Listing

Troponin T amino acid mutation (ΔK210) knock-in mice as a neonatal dilated cardiomyopathy model.

Pediatr Res 2020 Jun 20. Epub 2020 Jun 20.

Department of Cell Physiology, The Jikei University School of Medicine, Tokyo, Japan.

Background: Dilated cardiomyopathy (DCM) in children is often associated with poor morbidity and mortality and exhibits distinct pathological entities from those of adult DCM. Owing to the limited number of patients and the lack of a good animal model, the molecular mechanisms underlying pediatric DCM remain poorly understood. The purpose of this study is to establish an animal model of neonatal DCM and identify early progression factors. Read More

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http://dx.doi.org/10.1038/s41390-020-1016-1DOI Listing

The Cardiac Lipidome in Models of Cardiovascular Disease.

Metabolites 2020 Jun 17;10(6). Epub 2020 Jun 17.

Diabetes Research Envisioned and Accomplished in Manitoba (DREAM) Theme of the Children's Hospital Research Institute of Manitoba, 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada.

Cardiovascular disease (CVD) is the leading cause of death worldwide. There are numerous factors involved in the development of CVD. Among these, lipids have an important role in maintaining the myocardial cell structure as well as cardiac function. Read More

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http://dx.doi.org/10.3390/metabo10060254DOI Listing

Management of pediatric cardiac transplantation candidates with pulmonary hypertension and high pulmonary vascular resistance.

Turk J Pediatr 2020 ;62(3):461-467

Departments of Cardiovascular Surgery, Başkent University Faculty of Medicine, Ankara.

Background And Objectives: Right ventricular failure is an important cause of mortality and morbidity after orthotopic heart transplantation (OHT). The right ventricle of the donor may fail to accommodate to the high pulmonary vascular resistance (PVR) of the recipient. Pulmonary hypertension (PH) due to chronic heart failure with PVRi > 4 Wood units. Read More

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http://dx.doi.org/10.24953/turkjped.2020.03.013DOI Listing
January 2020

Delayed-type Hypersensitivity to Metals in Newly Diagnosed Patients with Nonischemic Dilated Cardiomyopathy.

Cardiovasc Toxicol 2020 Jun 15. Epub 2020 Jun 15.

Department of Internal Medicine and Cardiology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.

The causes of nonischemic dilated cardiomyopathy are classified as genetic or nongenetic, but environmental factors such as metal pollutants may interact with genetic susceptibility. The presence of metal particles has been detected in the myocardium, including in those patients with dilated cardiomyopathy. It is also known that hypersensitivity reactions can induce inflammation in tissue. Read More

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http://dx.doi.org/10.1007/s12012-020-09582-6DOI Listing
June 2020
2.060 Impact Factor

The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unreponsive to standard heart failure therapy.

Sci Rep 2020 Jun 17;10(1):9819. Epub 2020 Jun 17.

Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Phospholamban (PLN) plays a role in cardiomyocyte calcium handling as primary inhibitor of sarco/endoplasmic reticulum Ca-ATPase (SERCA). The p.(Arg14del) pathogenic variant in the PLN gene results in a high risk of developing dilated or arrhythmogenic cardiomyopathy with heart failure. Read More

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http://dx.doi.org/10.1038/s41598-020-66656-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300032PMC

The multiple faces of Danon disease.

Hellenic J Cardiol 2020 Jun 15. Epub 2020 Jun 15.

1(st) Cardiology Department, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece.

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http://dx.doi.org/10.1016/j.hjc.2020.06.004DOI Listing

The prevalence of atrial premature complexes in healthy Doberman Pinschers and their role in the diagnosis of occult dilated cardiomyopathy.

Authors:
J Eberhard G Wess

Vet J 2020 May - Jun;259-260:105475. Epub 2020 Jun 3.

Clinic of Small Animal Medicine, LMU University, Veterinärstrasse 13, 80539 Munich, Germany. Electronic address:

The importance of atrial premature complexes (APCs) as a possible marker of occult dilated cardiomyopathy (DCM) in Doberman Pinschers (DP) is unknown. The aim of this study was to identify APC in healthy DP and to investigate their role as early markers of occult DCM. Holter-ECG results from 561 examinations of 153 DP at different time points were retrospectively evaluated, with special emphasis on APCs. Read More

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http://dx.doi.org/10.1016/j.tvjl.2020.105475DOI Listing

Hemolysis and methemoglobinemia in a child with left ventricular assist Levitronix PediMag.

Int J Artif Organs 2020 Jun 18:391398820932175. Epub 2020 Jun 18.

Department of Pediatric Intensive Care, Hospital General Universitario Gregorio Marañon, Madrid, Spain.

A 5-month-old male was treated with left ventricular assist device due to cardiac failure secondary to dilated cardiomyopathy. The patient developed acute severe intravascular hemolysis with methemoglobinemia and renal failure, related to a mechanical problem due to pump cylinder misalignment. Secondary severe methemoglobinemia has not been previously described in patients undergoing ventricular assist device. Read More

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http://dx.doi.org/10.1177/0391398820932175DOI Listing

Peripheral Vascular Function in Dilated Cardiomyopathy of Different Etiology.

Angiology 2020 Jun 17:3319720932803. Epub 2020 Jun 17.

Department of Translational Medical Sciences, Federico II University School of Medicine, Naples, Italy.

Vascular function in dilated cardiomyopathy of different etiology has been poorly investigated. Moreover, reference values of flow-mediated dilation (FMD) in chronic heart failure (CHF) need to be updated according to the new standardized protocols. We characterized the vascular impairment in different stages of post-ischemic dilated cardiomyopathy (PI-DC) or idiopathic dilated cardiomyopathy (I-DC). Read More

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http://dx.doi.org/10.1177/0003319720932803DOI Listing