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DEPArray™ system: An automatic image-based sorter for isolation of pure circulating tumor cells.

Cytometry A 2018 Dec;93(12):1260-1266

Menarini Silicon Biosystems S.p.A, Bologna, Italy.

Circulating tumor cells (CTCs) are rare cells shed into the bloodstream by invasive tumors and their analysis offers a promising noninvasive tool to predict and monitor therapeutic responses. CTCs can be isolated from patient blood and their characterization at single-cell level can inform on the genomic landscape of a tumor. All CTC enrichment methods bear a burden of contaminating normal cells, which mandate a further step of purification to enable reliable downstream genetic analysis. Read More

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December 2018
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The relationship between trunk position sense and postural control in ataxic individuals.

Gait Posture 2018 Dec 6;68:258-263. Epub 2018 Dec 6.

Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey.

Background: The proprioceptive system plays a role in the maintenance of postural control more than the visual and vestibular systems in ataxic patients with postural control disorders, but the relationship between trunk proprioception and postural control has not been sufficiently investigated yet. This relationship can provide a different perspective to the ataxia rehabilitation.

Research Question: This study aimed to examine the relationship between trunk position sense and postural control in ataxic individuals by comparing them to healthy individuals. Read More

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December 2018

A randomized controlled trial to test efficacy of digital enhancements of storybooks in support of narrative comprehension and word learning.

J Exp Child Psychol 2018 Dec 11;179:212-226. Epub 2018 Dec 11.

Institute of Education, ELTE Eötvös Loránd University, 1053 Budapest, Hungary; Department of Language, Literature and Communication, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the Netherlands; Faculty of Arts and Education, University of Stavanger, 4036 Stavanger, Norway.

Experiments with film-like story presentations have been found to be beneficial in supporting children's story comprehension and word learning. The main goal of the current study was to disentangle the effects of visual and auditory enhancements in digital books. Participants were 99 typically developing children (41 boys and 58 girls) aged 4-6 years from two public kindergartens in Bursa, Turkey. Read More

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December 2018

Evaluation of three advanced methodologies, COLD-PCR, microarray and ddPCR, for identifying the mutational status by liquid biopsies in metastatic colorectal cancer patients.

Clin Chim Acta 2018 Dec 11. Epub 2018 Dec 11.

Unit of Genomic for the Diagnosis of Human Pathologies, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan 20132, Italy; Laboratory of Clinical Molecular Biology, IRCCS Ospedale San Raffaele, Milan, Italy; Università Vita-Salute San Raffaele, Milano, Italy.

A major effort has been focused on the detection of oncogenes' mutations in diverse types of clinical specimens including formalin-fixed and paraffin embedded tissues, presently the gold-standard samples, up to plasma, that constitute a noninvasive alternative source of tumor DNA. The reliable detection of mutations in circulating tumor DNA requires a high analytical sensitivity. Here, we applied three different highly sensitive methodologies (COLD-PCR, a microarray-based approach and the droplet digital PCR, ddPCR) to identify mutations in the plasma of 30 metastatic colorectal cancer patients previously genotyped on tissue biopsy. Read More

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December 2018

Mechanisms of acquired resistance to afatinib clarified with liquid biopsy.

PLoS One 2018 14;13(12):e0209384. Epub 2018 Dec 14.

Department of Internal Medicine, Division of Hematology, Respiratory Medicine and Oncology, Faculty of Medicine, Saga University, Saga, Japan.

Although mechanisms of acquired resistance to 1st and 3rd generation EGFR-TKI continue to be elucidated, there have been few clinical investigations into the mechanisms of acquired resistance to the 2nd generation EGFR-TKI afatinib. We analyzed data from 20 patients with advanced lung adenocarcinoma who acquired resistance to afatinib, including resistance during EGFR-TKI re-challenge. We examined EGFR T790M and C797S mutations, BRAF V600E mutation, and MET amplification with the MBP-QP method and with droplet digital PCR using ctDNA and re-biopsy samples obtained before and after afatinib treatment. Read More

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December 2018
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Detection of size of manufactured sand particles based on digital image processing.

PLoS One 2018 14;13(12):e0206135. Epub 2018 Dec 14.

Department of Radiation Oncology, Xiamen Cancer Hospital, First Affiliated Hospital of Xiamen University, Xiamen, Fujian Province, China.

The size distribution of manufactured sand particles has a significant influence on the quality of concrete. To overcome the shortcomings of the traditional vibration-sieving method, a manufactured sand casting/dispersing system was developed, based on the characteristics of the sand particle contours (as determined by backlit image acquisition) and an extraction mechanism. Algorithms for eliminating particles from the image that had be repeatedly captured, as well as for identifying incomplete particles at the boundaries of the image, granular contour segmentation, and the determination of an equivalent particle size, are studied. Read More

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December 2018

[The effect of the nasal packing material on nasal epithelial cells].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1900-1903

Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otolaryngology, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing, 100730,China.

The aim of this study is to investigate the effect of polyethylene glycol acrylate hybrid hydrogel degradation substance on nasal mucociliary transport system. In our experiment, the complex hydrogel were formed by the combination of different ratios of polyethyleneglycol diacrylate, chitosan and polyvinyl alcohol. The experiment was divided into four groups according to the international standard of medical devices. Read More

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December 2018
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Survey on the status of teledermatology in Austria.

J Dtsch Dermatol Ges 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Graz Medical University, Graz, Austria.

Background: The use of digital communication media is becoming increasingly important, with the primary aim of improving both treatment quality and patients' quality of life. In an effort to optimize telemedicine in the field of dermatology, we conducted a survey among dermatologists in Austria.

Methods: Statistical analysis of a questionnaire that was developed by a working group and sent to 769 Austrian dermatologists. Read More

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December 2018

The role of lip thickness in upper lip response to sagittal change of incisor position.

Orthod Craniofac Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Orthodontics and Dentofacial Orthopedics, Tufts University School of Dental Medicine, Boston, MA.

Objectives: To investigate the association between upper lip thickness and the amount of upper lip repositioning upon retraction of maxillary incisors.

Setting And Sample Population: Pre- and post-treatment lateral cephalograms of 101 patients were reviewed. All subjects were treated with fixed orthodontic appliances including extraction of two maxillary premolars. Read More

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December 2018

Kinetics of indocyanine green: Optimizing tumor to normal tissue fluorescence in image-guided oral cancer surgery applications.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.

Background: The study aimed to define indocyanine green (ICG) kinetics to determine the optimal ICG dose and surgical time for near-infrared fluorescence-guided oral cancer surgery.

Methods: Spectrometer and grayscale digital imaging were used to quantify the ICG kinetics in 12 patients with oral cancer. The fluorescence intensity and signal-to-background ratio (SBR) of tumor and normal tissue were tested at 1, 6, and 24 hours after ICG injection. Read More

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December 2018

Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders.

Ann Neurol 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania.

Objective: To use digital histology in a large autopsy cohort of Lewy Body Disorder (LBD) patients with dementia to test the hypotheses that co-occurring Alzheimer's disease (AD) pathology impacts the anatomic distribution of α-synuclein (SYN) pathology and that co-occurring neocortical tau pathology in LBD associates with worse cognitive performance and occurs in a pattern differing from AD.

Methods: Fifty-five autopsy-confirmed LBD (PDD: 36, DLB:19) patients and 25 AD patients were studied. LBD patients were categorized as having moderate/severe AD co-pathology (SYN+AD=20) or little/no AD co-pathology (SYN-AD=35). Read More

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December 2018

Coding of Experimental Conditions in Microfluidic Droplet Assays Using Colored Beads and Machine Learning Supported Image Analysis.

Small 2018 Dec 14:e1802384. Epub 2018 Dec 14.

Bio Pilot Plant, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, 07745, Jena, Germany.

To efficiently exploit the potential of several millions of droplets that can be considered as individual bioreactors in microfluidic experiments, methods to encode different experimental conditions in droplets are needed. The approach presented here is based on coencapsulation of colored polystyrene beads with biological samples. The decoding of the droplets, as well as content quantification, are performed by automated analysis of triggered images of individual droplets in-flow using bright-field microscopy. Read More

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December 2018

Surfacing tensions through making explicit our evaluative judgements of research.

Authors:
Rola Ajjawi

Med Educ 2019 Jan;53(1):11-12

Centre for Research in Assessment and Digital Learning, Deakin University, Melbourne, Victoria, Australia.

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January 2019

Applicability of telemedicine in the screening of diabetic retinopathy (DR): The first multicentre study in Italy. The No Blind Study.

Diabetes Metab Res Rev 2018 Dec 13:e3113. Epub 2018 Dec 13.

Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.

Aims: Diabetic retinopathy (DR) represents the main cause of blindness among adults in the industrialized Countries. Use of telemedicine could offer an easy, smart specialist fundus oculi examination, as well as putting in a screening program many patients who otherwise would be excluded.

Materials And Methods: The NO Blind is a transversal, multicentre, observational study. Read More

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December 2018

A study to investigate the impact of a blended learning teaching approach to teach pharmacy law.

Int J Pharm Pract 2018 Dec 13. Epub 2018 Dec 13.

School of Pharmacy, Newcastle University, Newcastle upon Tyne, UK.

Objective: To describe the implementation and assess the effect of a blended learning approach to teach pharmacy law.

Methods: Twenty didactic pharmacy law lectures were redeveloped to 9 h of flipped classroom sessions. Presession online videos delivered factual content created in-house. Read More

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December 2018

How Much Blood Could a JP Suck If a JP Could Suck Blood?

Laryngoscope 2018 Dec 13. Epub 2018 Dec 13.

Department of Otolaryngology Head and Neck Surgery at Chapel Hill, Chapel Hill, North Carolina, U.S.A.

Objective: Active surgical drains minimize fluid accumulation in the postoperative period. The Jackson-Pratt (JP) system consists of a silicone drain connected by flexible tubing to a bulb. When air in the bulb is evacuated, negative pressure is applied at the surgical site to aspirate fluid. Read More

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December 2018

Fully convolutional networks in multimodal nonlinear microscopy images for automated detection of head and neck carcinoma: A pilot study.

Head Neck 2018 Dec 12. Epub 2018 Dec 12.

Department of Otorhinolaryngology, Jena University Hospital, Jena, Germany.

Background: A fully convolutional neural networks (FCN)-based automated image analysis algorithm to discriminate between head and neck cancer and noncancerous epithelium based on nonlinear microscopic images was developed.

Methods: Head and neck cancer sections were used for standard histopathology and co-registered with multimodal images from the same sections using the combination of coherent anti-Stokes Raman scattering, two-photon excited fluorescence, and second harmonic generation microscopy. The images analyzed with semantic segmentation using a FCN for four classes: cancer, normal epithelium, background, and other tissue types. Read More

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December 2018

A parallel Homological Spanning Forest framework for 2D topological image analysis.

Pattern Recognit Lett 2016 Nov;83(1):49-58

Faculty of Mathematics, University of Vienna, Oskar-Morgenstern-Platz 1, Wien A-1090, Austria.

In [14], a topologically consistent framework to support parallel topological analysis and recognition for 2 digital objects was introduced. Based on this theoretical work, we focus on the problem of finding efficient algorithmic solutions for topological interrogation of a 2 digital object of interest of a presegmented digital image , using 4-adjacency between pixels of . In order to maximize the degree of parallelization of the topological processes, we use as many elementary unit processing as pixels the image has. Read More

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November 2016

The Emerging Environmental and Public Health Problem of Electronic Waste in India.

J Health Pollut 2017 Sep 7;7(15):1-7. Epub 2017 Sep 7.

Department of Chemistry, Manav Rachna University, Sector 43, Faridabad, India.

Background: Monumental progress has been made in the area of information and communication technology, leading to a tremendous increase in use of electronic equipment, especially computers and mobile phones. The expansion of production and consumption of electronic equipment along with its shorter life span has led to the generation of tremendous amounts of electronic waste (e-waste). In addition, there is a high level of trans-boundary movement of these devices as second-hand electronic equipment from developed countries, in the name of bridging the digital gap. Read More

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September 2017

Product development of a condenser dosimeter using a skin-insulated USB-A-substrate with a silicon X-ray diode.

Radiol Phys Technol 2018 Dec 13. Epub 2018 Dec 13.

Department of Physics, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba, Iwate, 028-3694, Japan.

To measure integral doses in image-guided radiation therapy, we developed an integral condenser dosimeter comprising a disposable USB-A mini-substrate with a 0.1-µF condenser and a silicon X-ray diode (Si-XD), a microcomputer (mbed) dock, and a personal computer (PC). The Si-XD is a high-sensitivity photodiode selected for detecting X-rays. Read More

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December 2018

Glucagon-like peptide-1 receptor expression after myocardial infarction: Imaging study using Ga-NODAGA-exendin-4 positron emission tomography.

J Nucl Cardiol 2018 Dec 13. Epub 2018 Dec 13.

Turku PET Centre, University of Turku, 20520, Turku, Finland.

Background: Activation of glucagon-like peptide-1 receptor (GLP-1R) signaling protects against cardiac dysfunction and remodeling after myocardial infarction (MI). The aim of the study was to evaluate Ga-NODAGA-exendin-4 positron emission tomography (PET) for assessment of GLP-1R expression after MI in rats.

Methods And Results: Rats were studied at 3 days, 1 and 12 weeks after permanent coronary ligation or a sham-operation. Read More

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December 2018
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3D printing anatomical models of head bones.

Surg Radiol Anat 2018 Dec 13. Epub 2018 Dec 13.

Anatomy Department, Hospital de Santa Maria, Instituto de Anatomia, Faculdade de Medicina da Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisbon, Portugal.

Purpose: In many medical schools, the study of Anatomy is becoming increasingly theoretical owing to the difficulty of having human body parts available, rather than offering the students the possibility of a more realistic and practical approach. We developed a project where we use a 3D printer to produce models of the human skull bones, with high quality and quantity to satisfy the needs for Anatomy classes and to be available for request to study at home.

Methods: We selected regular and well-shaped bones of the head upon which we based the 3D models. Read More

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December 2018

Decrease in interpretation time for both novice and experienced readers using a concurrent computer-aided detection system for digital breast tomosynthesis.

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

Advanced Medical Device Research Division, Korea Electrotechnology Research Institute, 111 Hanggaul-ro, Sangnok-gu, Ansan-si, Gyeonggi-do, 15588, Republic of Korea.

Objectives: To compare the diagnostic performance and interpretation time of digital breast tomosynthesis (DBT) for both novice and experienced readers with and without using a computer-aided detection (CAD) system for concurrent read.

Methods: CAD system was developed for concurrent read in DBT interpretation. In this observer performance study, we used an enriched sample of 100 DBT cases including 70 with and 30 without breast cancers. Read More

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December 2018

Energy Dispersive X-Ray Fluorescence Zn/Fe Ratiometric Determination of Zinc Levels in Expressed Prostatic Fluid: A Direct, Non-Invasive and Highly Accurate Screening for Prostate Cancer.

Acta Sci Cancer Biol 2018 Nov 10;2(9):20-26. Epub 2018 Oct 10.

The Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Maryland, United States of America.

Prostate specific antigen (PSA) does not provide the reliability that is required for the accurate urology screening of prostate cancer (PCa). Consequently, there has been a major focus and search for a simple, rapid, direct, preferably non-invasive, and highly accurate biomarker and procedure for the urology screening for prostate cancer. Virtually all PCa cases exhibit a marked decrease in zinc in prostate tissue and in prostatic fluid. Read More

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November 2018

Design of a 3D navigation template to guide the screw trajectory in spine: a step-by-step approach using Mimics and 3-Matic software.

J Spine Surg 2018 Sep;4(3):645-653

Department of Spine Surgery, Digital Orthopedic Institute, Orthopedic Hospital, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Second Medical College of Wenzhou Medical University, Zhejiang Spine Surgery Center, Wenzhou 325027, China.

Rapid development of 3D printing techniques has led to the design of navigation templates to assist with accurate insertion of pedicle screws in last decades. However, there are still without the precise step-by-step methods to design 3D navigation templates from computed tomography (CT) images. Our present article provides a detailed protocol to allow the readers or researchers to obtain the 3D navigation template easily, and assist with pedicle screw insertion in their future research and surgery. Read More

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September 2018

Bilateral Fracture of the Handle Malleus: A Case Report and Review of the Literature.

J Clin Imaging Sci 2018 15;8:49. Epub 2018 Nov 15.

Department of Radiology, Division of Neuroradiology, University of Michigan Health System. Ann Arbor, Michigan, USA.

Malleus fracture is a rare condition. Usually, the handle of the malleus is involved, and we do not find reports in the literature of this condition in the bilateral presentation. It is present as sudden conductive hearing loss commonly after digital manipulation of the external auditory canal. Read More

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November 2018

Evaluation of prostate-specific antigen density in the diagnosis of prostate cancer combined with magnetic resonance imaging before biopsy in men aged 70 years and older with elevated PSA.

Mol Clin Oncol 2018 Dec 19;9(6):656-660. Epub 2018 Sep 19.

Department of Urology, Keio University School of Medicine, Tokyo 160-8582, Japan.

There is an increasing proportion of individuals aged 70 years and older, as well as an increasing life expectancy worldwide. The present study may guide the management of older patients with elevated prostate specific antigen (PSA). The medical records of 241 older men aged >70 years who underwent multiparametric magnetic resonance imaging (mpMRI) before prostate biopsy (PBx) at our institution were reviewed retrospectively. Read More

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December 2018

Identification of rare levels of methylated tumor DNA fragments using an optimized bias based pre-amplification-digital droplet PCR (OBBPA-ddPCR).

Oncotarget 2018 Nov 16;9(90):36137-36150. Epub 2018 Nov 16.

Institute of Clinical Chemistry and Laboratory Medicine, Carl Gustav Carus University Hospital, Technical University of Dresden, Dresden, Germany.

Background: The analysis of aberrant DNA methylations is used for the diagnosis of cancer as significant changes in the gene methylation pattern are often detected during early carcinogenesis. In this study, we evaluated the performance of a two-step method that combines pre-amplification with ddPCR technique.

Results: By using ddPCR, the dependence of amplification efficiency for methylated and unmethylated DNA fragments on the relevant MgCl concentration and the annealing temperature was established in addition to the primer design. Read More

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November 2018

The Over-Extended Mind? Pink Noise and the Ethics of Interaction-Dominant Systems.

Nanoethics 2018 1;12(3):269-281. Epub 2018 Nov 1.

4Department of Health and Social Sciences, UWE, Bristol, Coldharbour Lane, Bristol, BS16 1QY UK.

There is a growing recognition within cognitive enhancement and neuroethics debates of the need for greater emphasis on cognitive artefacts. This paper aims to contribute to this broadening and expansion of the cognitive-enhancement and neuroethics debates by focusing on a particular form of relation or coupling between humans and cognitive artefacts: interaction-dominance. We argue that interaction-dominance as an emergent property of some human-cognitive artefact relations has important implications for understanding the attribution and distribution of causal and other forms of responsibility as well as agency relating to the actions of human-cognitive artefact couplings. Read More

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November 2018

Reliability and accuracy of linear measurements in cone-beam computed tomography using different software programs and voxel sizes.

J Conserv Dent 2018 Nov-Dec;21(6):607-612

Department of Dentistry, State University of Maringá, Maringá, PR, Brazil.

Objectives: The aim of this study is to evaluate the accuracy of linear measurements on cone-beam computed tomography (CBCT) images using three software programs and different voxel sizes.

Methods: Ten human mandibles with 25 silica markers were scanned for 0.250-, 0. Read More

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December 2018
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REASSURED diagnostics to inform disease control strategies, strengthen health systems and improve patient outcomes.

Nat Microbiol 2019 Jan 13;4(1):46-54. Epub 2018 Dec 13.

London School of Hygiene and Tropical Medicine, London, England.

Lack of access to quality diagnostics remains a major contributor to health burden in resource-limited settings. It has been more than 10 years since ASSURED (affordable, sensitive, specific, user-friendly, rapid, equipment-free, delivered) was coined to describe the ideal test to meet the needs of the developing world. Since its initial publication, technological innovations have led to the development of diagnostics that address the ASSURED criteria, but challenges remain. Read More

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January 2019

Use of the Normalized Difference Road Landside Index (NDRLI)-based method for the quick delineation of road-induced landslides.

Sci Rep 2018 Dec 13;8(1):17815. Epub 2018 Dec 13.

Key Laboratory of Environment Change and Resources Use in Beibu Gulf, Ministry of Education, Guangxi Teachers Education University, 175 Mingxiu East St., Nanning, 530001, China.

Recognition and classification of road-related landslides are a critical requirement in pre- and post-disaster hazard analysis. They are primarily done through field mapping or manual image interpretation from commercial satellites images. This paper developed a Normalized Difference Road Landside Index (NDRLI)-based method to delineate road-induced landslides and enhance their presence in remotely sensed digital imagery based on free Landsat Operational Land Imager (OLI) sources. Read More

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December 2018

Elements of Trust in Digital Health Systems: Scoping Review.

J Med Internet Res 2018 Dec 13;20(12):e11254. Epub 2018 Dec 13.

Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.

Background: Information and communication technologies have long become prominent components of health systems. Rapid advances in digital technologies and data science over the last few years are predicted to have a vast impact on health care services, configuring a paradigm shift into what is now commonly referred to as digital health. Forecasted to curb rising health costs as well as to improve health system efficiency and safety, digital health success heavily relies on trust from professional end users, administrators, and patients. Read More

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December 2018
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What is an appropriate level of evidence for a digital health intervention?

Lancet 2018 Dec 7. Epub 2018 Dec 7.

National Institute for Health and Care Excellence, London, UK; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

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December 2018

Deadbeat-fuzzy controller for the power control of a Doubly Fed Induction Generator based wind power system.

ISA Trans 2018 Dec 5. Epub 2018 Dec 5.

Federal University of ABC - Santo André, SP, Brazil. Electronic address:

This paper proposes a Fuzzy Logic Controller for improvement of the steady-state response of a Doubly Fed Induction Generator used in a wind energy system, and governed by means of a Deadbeat Power Controller. The generator mathematical model is consistent with the Stator Flux oriented strategy in the synchronous reference frame. Different simulation scenarios were developed in Matlab/Simulink to evaluate the dynamic and the steady-state responses. Read More

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December 2018

Esophageal atresia, Europe, and the future: BAPS Journal of Pediatric Surgery Lecture.

Authors:
Benno Ure

J Pediatr Surg 2018 Nov 7. Epub 2018 Nov 7.

Department of Pediatric Surgery, Hannover Medical School, Carl-Neuberg-Straße 130625, Hannover, Germany. Electronic address:

Europe has changed remarkably over the past decades and so have concepts and outcomes of esophageal atresia repair. In this article, both the efforts to create a united Europe and the achievements in dealing with esophageal atresia from the 1950s on are outlined. Furthermore, this paper deals with the future of pediatric surgery and is focused on two aspects: the "Fourth Industrial Revolution" which builds on the digital revolution, artificial intelligence and robotics, and its potential impact on pediatric surgery and the life of patients. Read More

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November 2018

Calibrated Breast Density Measurements.

Acad Radiol 2018 Dec 10. Epub 2018 Dec 10.

Cancer Epidemiology Department, Moffitt Cancer Center & Research Institute, 12902 Bruce B Downs Blvd, Mail Stop: MRC Can/Cont, Tampa, FL 33612. Electronic address:

Rationale And Objectives: Mammographic density is an important risk factor for breast cancer, but translation to the clinic requires assurance that prior work based on mammography is applicable to current technologies. The purpose of this work is to evaluate whether a calibration methodology developed previously produces breast density metrics predictive of breast cancer risk when applied to a case-control study.

Materials And Methods: A matched case control study (n = 319 pairs) was used to evaluate two calibrated measures of breast density. Read More

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December 2018

Assessment of right atrium dysfunction in patients with obstructive sleep apnea syndrome using velocity vector imaging.

Cardiovasc Ultrasound 2018 Dec 13;16(1):32. Epub 2018 Dec 13.

Department of Echocardiography, Qingdao University Affiliated Hospital, No. 16 Jiangsu Road, Qingdao, 266001, China.

Background And Objectives: This study aimed to assess the changes of RA function in patients with obstructive sleep apnea syndrome (OSAS) using velocity vector imaging (VVI) and to evaluate the application of VVI technology.

Methods: According to the apnea-hypopnea index (AHI), 71 patients with OSAS were divided into three groups: mild, moderate, and severe. A total of 30 cases of healthy subjects were enrolled as the control group. Read More

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December 2018

Healthcare establishments as owner-operators of digital billboards: making the most of excellent roadside visibility and high traffic counts to better connect with patients.

BMC Health Serv Res 2018 Dec 14;18(Suppl 3):928. Epub 2018 Dec 14.

Willis-Knighton Health System, 2600 Greenwood Road, Shreveport, LA, 71103, USA.

Background: Given the importance of communicating effectively with current and prospective patients, healthcare institutions must direct considerable energies toward achieving associated excellence. Pursuits usually center on addressing the marketing communications mix properly, but in order to maximize communications prowess, attention also should be directed toward incorporating emerging communications innovations, when and where possible, to bolster opportunities to connect with patients.

Discussion: In pursuit of communications excellence, Willis-Knighton Health System's executives reflected on campus dynamics in the context of modern outdoor advertising technologies, namely, digital billboards, which present electronic advertisements on-demand, around-the-clock. Read More

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December 2018

New regression equations for mixed dentition space analysis in Nepalese mongoloids.

BMC Oral Health 2018 Dec 13;18(1):214. Epub 2018 Dec 13.

Department of Orthodontics, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.

Background: Mixed dentition space analysis methods using regression equations, namely, Moyers' analysis and Tanaka-Johnston analysis are commonly used around the world. However, the applicability of these analyses among different racial groups have been questioned. The primary objective of this study was to assess the applicability of the Moyers' and Tanaka-Johnston analyses among Nepalese Mongoloids and to develop regression equations for the same population if needed. Read More

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December 2018

Effect of Gender on the Outcome of Patients Receiving Immune Checkpoint Inhibitors for Advanced Cancer: A Systematic Review and Meta-Analysis of Phase III Randomized Clinical Trials.

J Clin Med 2018 Dec 12;7(12). Epub 2018 Dec 12.

Department of Medical, Oral and Biotechnological Sciences and CeSI-MeT, G. D'Annunzio University, 66100 Chieti, Italy.

Evidence has recently emerged on the influence of gender on the immune system. In this systematic review and meta-analysis of phase III randomized clinical trials (RCTs), we explored the impact of gender on survival in patients with advanced cancer treated with immune checkpoint inhibitors (ICIs). We performed a comprehensive search of the literature updated to April 2018, including the Cochrane Central Register of Controlled Trials, PubMed, and EMBASE. Read More

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December 2018

Characterization of Tunable Micro-Lenses with a Versatile Optical Measuring System.

Sensors (Basel) 2018 Dec 12;18(12). Epub 2018 Dec 12.

STMicroelectronics, 20010 Cornaredo (Mi), Italy.

In this work, we present the results of the opto⁻electro⁻mechanical characterization of tunable micro-lenses, Tlens, performed with a single-spot optical measuring system. Tested devices are composed of a transparent soft polymer layer that is deposited on a supporting glass substrate and is covered by a glass membrane with a thin-film piezoelectric actuator on top. Near-infrared optical low-coherence reflectometry is exploited for both static and low-frequency dynamic analyses in the time domain. Read More

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December 2018

Food Parenting Practices among Parents with Overweight and Obesity: A Systematic Review.

Nutrients 2018 Dec 12;10(12). Epub 2018 Dec 12.

Applied Psychology, International Digital Laboratory, Warwick Manufacturing Group, University of Warwick, Coventry CV4 7AL, UK.

Given the links between parental obesity and eating psychopathology in their children, it is important to understand the mechanisms via which unhealthy relationships with eating are passed from generation to generation. The aim was to review research focusing on food-related parenting practices (FPPs) used by parents with overweight/obesity. Web of Science, PubMed and PsycINFO were searched. Read More

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December 2018

Damage of Hygrothermally Conditioned Carbon Epoxy Composites under High-Velocity Impact.

Materials (Basel) 2018 Dec 12;11(12). Epub 2018 Dec 12.

Hubei Key Laboratory of Theory and Application of Advanced Materials Mechanics, Wuhan University of Technology, Wuhan 430070, China.

The influence of hygrothermal aging on high-velocity impact damage of carbon fiber-reinforced polymer (CFRP) laminates is investigated. Composite laminate specimens were preconditioned in water at 70 °C. The laminates were subsequently impacted by flat-, sphere-, and cone- ended projectiles with velocities of 45, 68, and 86 m/s. Read More

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December 2018

Energy and Spectrally Efficient Modulation Scheme for IoT Applications.

Sensors (Basel) 2018 Dec 11;18(12). Epub 2018 Dec 11.

Electrical Engineering Department, Faculty of Engineering, Assiut University, Assiut 71515, Egypt.

Due to the Internet of Things (IoT) requirements for a high-density network with low-cost and low-power physical (PHY) layer design, the low-power budget transceiver systems have drawn momentous attention lately owing to their superior performance enhancement in both energy efficiency and hardware complexity reduction. As the power budget of the classical transceivers is envisioned by using inefficient linear power amplifiers (PAs) at the transmitter (TX) side and by applying high-resolution analog to digital converters (ADCs) at the receiver (RX) side, the transceiver architectures with low-cost PHY layer design (i.e. Read More

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December 2018

Remote Sensing Assessment of Safety Risk of Iron Tailings Pond Based on Runoff Coefficient.

Sensors (Basel) 2018 Dec 11;18(12). Epub 2018 Dec 11.

Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines, Northeastern University, Shenyang 110819, China.

Iron tailings ponds are engineered dam and dyke systems used to capture iron tailings. They are high-risk hazards with high potential energy. If the tailings dam broke, it would pose a serious threat to the surrounding ecological environment, residents' lives, and property. Read More

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December 2018

Interfacing Digital Microfluidics with Ambient Mass Spectrometry Using SU-8 as Dielectric Layer.

Micromachines (Basel) 2018 Dec 8;9(12). Epub 2018 Dec 8.

Drug Research Program, Faculty of Pharmacy, Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Viikinkaari 5E, 00790 Helsinki, Finland.

This work describes the interfacing of electrowetting-on-dielectric based digital microfluidic (DMF) sample preparation devices with ambient mass spectrometry (MS) via desorption atmospheric pressure photoionization (DAPPI). The DMF droplet manipulation technique was adopted to facilitate drug distribution and metabolism assays in droplet scale, while ambient mass spectrometry (MS) was exploited for the analysis of dried samples directly on the surface of the DMF device. Although ambient MS is well-established for bio- and forensic analyses directly on surfaces, its interfacing with DMF is scarce and requires careful optimization of the surface-sensitive processes, such as sample precipitation and the subsequent desorption/ionization. Read More

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December 2018

Manufacturing Signatures of Injection Molding and Injection Compression Molding for Micro-Structured Polymer Fresnel Lens Production.

Micromachines (Basel) 2018 Dec 10;9(12). Epub 2018 Dec 10.

Department of Mechanical Engineering, Technical University of Denmark (DTU), 2800 Kgs. Lyngby, Denmark.

Injection compression molding (ICM) provides enhanced optical performances of molded polymer optics in terms of birefringence and transmission of light compared to Injection molding (IM). Nevertheless, ICM requires case-dedicated process optimization to ensure that the required high accuracy geometrical replication is achieved, particularly especially in the case of surface micro-features. In this study, two factorial designs of experiments (DOE) were carried out to investigate the replication capability of IM and ICM on a micro structured Fresnel lens. Read More

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December 2018

Effect of the Transition Points Mismatch on Quanta Image Sensors.

Sensors (Basel) 2018 Dec 10;18(12). Epub 2018 Dec 10.

School of Microelectronics, Tianjin University and Tianjin Key Laboratory of Imaging and Sensing Microelectronic Technology, No. 92 Weijin Road, Nankai District, Tianjin 300072, China.

Mathematical models and imaging models that show the relationship between the transition points mismatch of analog-to-digital converters (ADCs) and the bit error rate (BER) in single-bit and multi-bit quanta image sensors (QISs) are established. The mathematical models suggest that when the root-mean-square (r.m. Read More

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December 2018