120,938 results match your criteria Digital Journal of Ophthalmology[Journal]


Pet robot intervention for people with dementia: A systematic review and meta-analysis of randomized controlled trials.

Psychiatry Res 2018 Dec 6;271:516-525. Epub 2018 Dec 6.

School of Nursing, Jilin University, Changchun, China; Department of Pharmacology, college of Basic Medical sciences, Jilin University, Changchun, China. Electronic address:

This study aims to systematically evaluate the efficacy of Pet robot intervention (PRI) for people with dementia. Two waves of electronic searches of the PubMed, EMBASE, Web of Science, Cochrane library, IEEE Digital Library and PsycINFO databases were conducted. In total, eight articles from six randomized controlled trials (RCTs) met the eligibility criteria and were included in this systematic review. Read More

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December 2018

A generative model of realistic brain cells with application to numerical simulation of the diffusion-weighted MR signal.

Neuroimage 2018 Dec 12. Epub 2018 Dec 12.

Centre for Medical Image Computing and Dept of Computer Science, University College London, London, UK.

To date, numerical simulations of the brain tissue have been limited by their lack of realism and flexibility. The purpose of this work is to propose a controlled and flexible generative model for brain cell morphology and an efficient computational pipeline for the reliable and robust simulation of realistic cellular structures with application to numerical simulation of intra-cellular diffusion-weighted MR (DW-MR) signal features. Inspired by the advances in computational neuroscience for modelling brain cells, we propose a generative model that enables users to simulate molecular diffusion within realistic digital brain cells, such as neurons, in a completely controlled and flexible fashion. Read More

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December 2018

Identification of a circulating miRNA signature in extracellular vesicles collected from amyotrophic lateral sclerosis patients.

Brain Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Chemistry and Biochemistry, Université de Moncton, 18 Antonine-Maillet Avenue, Moncton, New Brunswick, E1A 3E9, Canada. Electronic address:

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder associated with the progressive death of motor neurons. Mean survival for a patient diagnosed with ALS is between 2 to 5 years. Early and efficient diagnosis of the various forms of ALS remains a significant challenge, resulting in a need to identify clinically-relevant biomarkers in readily accessible body fluids. Read More

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December 2018

Ulnar Artery Occlusion and severity markers of vasculopathy in Systemic sclerosis: a multicenter cross-sectional study.

Arthritis Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

Department of Internal Medicine and Clinical Immunology, CHU Rennes, Univ Rennes, France.

Objective: to evaluate the association of ulnar artery occlusion (UAO) assessed by Doppler Ultrasonography (dUS) with the severity markers of systemic sclerosis (SSc) METHODS: 204 unselected patients fulfilling 2013 ACR/EULAR classification criteria for SSc were included in this cross-sectional multicenter study. All patients benefit from bilateral hand dUS evaluating the presence of UAO and clinical/paraclinical visceral evaluation according to current guidelines. Univariable and multivariable ordinal regression models were conducted, grading the severity of UAO as "no UAO", "only one UAO" and "UAO on both hands" and assessing its association with clinical features of SSc. Read More

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December 2018
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Jim's view: analog to digital conversion in biology.

Authors:
James E Rothman

FEBS Lett 2018 Dec 15. Epub 2018 Dec 15.

Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA.

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December 2018

Renaming of 'Candidatus Methylocucumis oryzae' as Methylocucumis oryzae gen. nov., sp. nov., a novel Type I methanotroph isolated from India.

Antonie Van Leeuwenhoek 2018 Dec 15. Epub 2018 Dec 15.

MACS Agharkar Research Institute, G.G. Agarkar Road, Pune, 411004, Maharashtra, India.

Candidatus Methylocucumis (Mcu.) oryzae, strain Sn10-6, a Gram-negative, pale pink pigmented, motile, large Type I methanotroph (3-6 µm × 1.5-2 µm) was recently isolated from an Indian rice field. Read More

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December 2018

Elements of science and fiction.

Authors:
Suze Kundu

Nat Chem 2019 Jan;11(1):13-16

Head of Community Engagement, Digital Science, London, UK.

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January 2019

Neuroinspired unsupervised learning and pruning with subquantum CBRAM arrays.

Nat Commun 2018 Dec 14;9(1):5312. Epub 2018 Dec 14.

Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA, 92093, USA.

Resistive RAM crossbar arrays offer an attractive solution to minimize off-chip data transfer and parallelize on-chip computations for neural networks. Here, we report a hardware/software co-design approach based on low energy subquantum conductive bridging RAM (CBRAM®) devices and a network pruning technique to reduce network level energy consumption. First, we demonstrate low energy subquantum CBRAM devices exhibiting gradual switching characteristics important for implementing weight updates in hardware during unsupervised learning. Read More

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December 2018

Comprehensive scoping review of health research using social media data.

BMJ Open 2018 Dec 14;8(12):e022931. Epub 2018 Dec 14.

Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK.

Introduction: The rising popularity of social media, since their inception around 20 years ago, has been echoed in the growth of health-related research using data derived from them. This has created a demand for literature reviews to synthesise this emerging evidence base and inform future activities. Existing reviews tend to be narrow in scope, with limited consideration of the different types of data, analytical methods and ethical issues involved. Read More

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December 2018

Psychiatrists' Attitudes Toward Disruptive New Technologies: Mixed-Methods Study.

JMIR Ment Health 2018 Dec 14;5(4):e10240. Epub 2018 Dec 14.

Department of Adult Psychiatry and Medical Psychology, Sorbonne Université, Saint-Antoine Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.

Background: Recent discoveries in the fields of machine learning (ML), Ecological Momentary Assessment (EMA), computerized adaptive testing (CAT), digital phenotype, imaging, and biomarkers have brought about a new paradigm shift in medicine.

Objective: The aim of this study was to explore psychiatrists' perspectives on this paradigm through the prism of new clinical decision support systems (CDSSs). Our primary objective was to assess the acceptability of these new technologies. Read More

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December 2018

Predictors of Engagement, Response to Follow Up, and Extent of Alcohol Reduction in Users of a Smartphone App (Drink Less): Secondary Analysis of a Factorial Randomized Controlled Trial.

JMIR Mhealth Uhealth 2018 Dec 14;6(12):e11175. Epub 2018 Dec 14.

Department of Behavioural Science and Health, University College London, London, United Kingdom.

Background: Digital interventions for alcohol can help achieve reductions in hazardous and harmful alcohol consumption. The Drink Less app was developed using evidence and theory, and a factorial randomized controlled trial (RCT) suggested that 4 of its intervention modules may assist with drinking reduction. However, low engagement is an important barrier to effectiveness, and low response to follow up is a challenge for intervention evaluation. Read More

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December 2018

Data Integrity-Based Methodology and Checklist for Identifying Implementation Risks of Physiological Sensing in Mobile Health Projects: Quantitative and Qualitative Analysis.

JMIR Mhealth Uhealth 2018 Dec 14;6(12):e11896. Epub 2018 Dec 14.

Mobile Health Systems Lab, Institute of Robotics and Intelligent Systems, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.

Background: Mobile health (mHealth) technologies have the potential to bring health care closer to people with otherwise limited access to adequate health care. However, physiological monitoring using mobile medical sensors is not yet widely used as adding biomedical sensors to mHealth projects inherently introduces new challenges. Thus far, no methodology exists to systematically evaluate these implementation challenges and identify the related risks. Read More

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December 2018

Age-and-sex stratified prevalence of atrial fibrillation in rural Western India: Results of SMART-India, a population-based screening study.

Int J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA; Cardiology Division, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.

Background: Early detection of Atrial Fibrillation (AF) is a public health priority across the globe because AF-related strokes are preventable. Despite an ongoing stroke epidemic in India, a public health strategy for AF screening and treatment is missing because the epidemiology of AF in India remains poorly defined.

Methods: This population-based study used mobile technology to derive age and sex-stratified AF prevalence by screening 7 participants in each of six age and sex strata (age 40-55, 56-65, 65+, and male and female) from 50 villages (2100 participants). Read More

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December 2018

Translational research on clinically failed zirconia implants.

Dent Mater 2018 Dec 11. Epub 2018 Dec 11.

HEPIA, University of Applied Sciences - Western Switzerland (HES-SO), Geneva, Switzerland. Electronic address:

Objectives: To provide fractographic analysis of clinically fractured zirconia implants recovered with their cemented crown. To calculate bending moments, corresponding stress and crack onset location on the implant's fracture surface using a mathematical model integrating spatial coordinates of the crown-implant part and occlusal loading obtained from 2D and 3D images.

Methods: 15 fractured zirconia implants parts (11 posterior and 4 anterior) with their all- ceramic crowns still cemented on it were recovered. Read More

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December 2018

Contributions of citizen scientists to arthropod vector data in the age of digital epidemiology.

Curr Opin Insect Sci 2018 Aug 16;28:98-104. Epub 2018 May 16.

Department of Entomology, 2475 TAMU, Texas A&M University, College Station, TX 77843, USA.

Citizen-collected arthropod vectors are useful for epidemiological studies of vector-borne disease, especially since the vectors encountered by the public are the subset of vectors in nature that have a disproportionate impact on health. Programs integrating educational efforts with collecting efforts may be particularly effective for public health initiatives, resulting in an empowered public with knowledge of vector-borne disease prevention. Citizen science programs have been successfully implemented for the collection of unprecedented sample sets of mosquitos, ticks, and triatomines. Read More

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Hydrostatic High-Pressure Post-Processing of Specimens Fabricated by DLP, SLA, and FDM: An Alternative for the Sterilization of Polymer-Based Biomedical Devices.

Materials (Basel) 2018 Dec 13;11(12). Epub 2018 Dec 13.

Department of Mechanical Engineering and Advanced Materials, Tecnologico de Monterrey, Monterrey 64849, NL, Mexico.

In this work, we assess the effects of sterilization in materials manufactured using additive manufacturing by employing a sterilization technique used in the food industry. To estimate the feasibility of the hydrostatic high-pressure (HHP) sterilization of biomedical devices, we have evaluated the mechanical properties of specimens produced by commercial 3D printers. Evaluations of the potential advantages and drawbacks of Fused Deposition Modeling (FDM), Digital Light Processing (DLP) technology, and Stereolithography (SLA) were considered for this study due to their widespread availability. Read More

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December 2018

DEPArray™ system: An automatic image-based sorter for isolation of pure circulating tumor cells.

Cytometry A 2018 Dec;93(12):1260-1266

Menarini Silicon Biosystems S.p.A, Bologna, Italy.

Circulating tumor cells (CTCs) are rare cells shed into the bloodstream by invasive tumors and their analysis offers a promising noninvasive tool to predict and monitor therapeutic responses. CTCs can be isolated from patient blood and their characterization at single-cell level can inform on the genomic landscape of a tumor. All CTC enrichment methods bear a burden of contaminating normal cells, which mandate a further step of purification to enable reliable downstream genetic analysis. Read More

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December 2018
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The relationship between trunk position sense and postural control in ataxic individuals.

Gait Posture 2018 Dec 6;68:258-263. Epub 2018 Dec 6.

Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey.

Background: The proprioceptive system plays a role in the maintenance of postural control more than the visual and vestibular systems in ataxic patients with postural control disorders, but the relationship between trunk proprioception and postural control has not been sufficiently investigated yet. This relationship can provide a different perspective to the ataxia rehabilitation.

Research Question: This study aimed to examine the relationship between trunk position sense and postural control in ataxic individuals by comparing them to healthy individuals. Read More

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December 2018

A randomized controlled trial to test efficacy of digital enhancements of storybooks in support of narrative comprehension and word learning.

J Exp Child Psychol 2018 Dec 11;179:212-226. Epub 2018 Dec 11.

Institute of Education, ELTE Eötvös Loránd University, 1053 Budapest, Hungary; Department of Language, Literature and Communication, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the Netherlands; Faculty of Arts and Education, University of Stavanger, 4036 Stavanger, Norway.

Experiments with film-like story presentations have been found to be beneficial in supporting children's story comprehension and word learning. The main goal of the current study was to disentangle the effects of visual and auditory enhancements in digital books. Participants were 99 typically developing children (41 boys and 58 girls) aged 4-6 years from two public kindergartens in Bursa, Turkey. Read More

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December 2018

Evaluation of three advanced methodologies, COLD-PCR, microarray and ddPCR, for identifying the mutational status by liquid biopsies in metastatic colorectal cancer patients.

Clin Chim Acta 2018 Dec 11. Epub 2018 Dec 11.

Unit of Genomic for the Diagnosis of Human Pathologies, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan 20132, Italy; Laboratory of Clinical Molecular Biology, IRCCS Ospedale San Raffaele, Milan, Italy; Università Vita-Salute San Raffaele, Milano, Italy.

A major effort has been focused on the detection of oncogenes' mutations in diverse types of clinical specimens including formalin-fixed and paraffin embedded tissues, presently the gold-standard samples, up to plasma, that constitute a noninvasive alternative source of tumor DNA. The reliable detection of mutations in circulating tumor DNA requires a high analytical sensitivity. Here, we applied three different highly sensitive methodologies (COLD-PCR, a microarray-based approach and the droplet digital PCR, ddPCR) to identify mutations in the plasma of 30 metastatic colorectal cancer patients previously genotyped on tissue biopsy. Read More

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December 2018

Mechanisms of acquired resistance to afatinib clarified with liquid biopsy.

PLoS One 2018 14;13(12):e0209384. Epub 2018 Dec 14.

Department of Internal Medicine, Division of Hematology, Respiratory Medicine and Oncology, Faculty of Medicine, Saga University, Saga, Japan.

Although mechanisms of acquired resistance to 1st and 3rd generation EGFR-TKI continue to be elucidated, there have been few clinical investigations into the mechanisms of acquired resistance to the 2nd generation EGFR-TKI afatinib. We analyzed data from 20 patients with advanced lung adenocarcinoma who acquired resistance to afatinib, including resistance during EGFR-TKI re-challenge. We examined EGFR T790M and C797S mutations, BRAF V600E mutation, and MET amplification with the MBP-QP method and with droplet digital PCR using ctDNA and re-biopsy samples obtained before and after afatinib treatment. Read More

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December 2018
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Detection of size of manufactured sand particles based on digital image processing.

PLoS One 2018 14;13(12):e0206135. Epub 2018 Dec 14.

Department of Radiation Oncology, Xiamen Cancer Hospital, First Affiliated Hospital of Xiamen University, Xiamen, Fujian Province, China.

The size distribution of manufactured sand particles has a significant influence on the quality of concrete. To overcome the shortcomings of the traditional vibration-sieving method, a manufactured sand casting/dispersing system was developed, based on the characteristics of the sand particle contours (as determined by backlit image acquisition) and an extraction mechanism. Algorithms for eliminating particles from the image that had be repeatedly captured, as well as for identifying incomplete particles at the boundaries of the image, granular contour segmentation, and the determination of an equivalent particle size, are studied. Read More

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December 2018

[The effect of the nasal packing material on nasal epithelial cells].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(24):1900-1903

Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otolaryngology, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing, 100730,China.

The aim of this study is to investigate the effect of polyethylene glycol acrylate hybrid hydrogel degradation substance on nasal mucociliary transport system. In our experiment, the complex hydrogel were formed by the combination of different ratios of polyethyleneglycol diacrylate, chitosan and polyvinyl alcohol. The experiment was divided into four groups according to the international standard of medical devices. Read More

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December 2018
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Survey on the status of teledermatology in Austria.

J Dtsch Dermatol Ges 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, Graz Medical University, Graz, Austria.

Background: The use of digital communication media is becoming increasingly important, with the primary aim of improving both treatment quality and patients' quality of life. In an effort to optimize telemedicine in the field of dermatology, we conducted a survey among dermatologists in Austria.

Methods: Statistical analysis of a questionnaire that was developed by a working group and sent to 769 Austrian dermatologists. Read More

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December 2018

The role of lip thickness in upper lip response to sagittal change of incisor position.

Orthod Craniofac Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Orthodontics and Dentofacial Orthopedics, Tufts University School of Dental Medicine, Boston, MA.

Objectives: To investigate the association between upper lip thickness and the amount of upper lip repositioning upon retraction of maxillary incisors.

Setting And Sample Population: Pre- and post-treatment lateral cephalograms of 101 patients were reviewed. All subjects were treated with fixed orthodontic appliances including extraction of two maxillary premolars. Read More

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December 2018

Kinetics of indocyanine green: Optimizing tumor to normal tissue fluorescence in image-guided oral cancer surgery applications.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.

Background: The study aimed to define indocyanine green (ICG) kinetics to determine the optimal ICG dose and surgical time for near-infrared fluorescence-guided oral cancer surgery.

Methods: Spectrometer and grayscale digital imaging were used to quantify the ICG kinetics in 12 patients with oral cancer. The fluorescence intensity and signal-to-background ratio (SBR) of tumor and normal tissue were tested at 1, 6, and 24 hours after ICG injection. Read More

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December 2018

Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders.

Ann Neurol 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania.

Objective: To use digital histology in a large autopsy cohort of Lewy Body Disorder (LBD) patients with dementia to test the hypotheses that co-occurring Alzheimer's disease (AD) pathology impacts the anatomic distribution of α-synuclein (SYN) pathology and that co-occurring neocortical tau pathology in LBD associates with worse cognitive performance and occurs in a pattern differing from AD.

Methods: Fifty-five autopsy-confirmed LBD (PDD: 36, DLB:19) patients and 25 AD patients were studied. LBD patients were categorized as having moderate/severe AD co-pathology (SYN+AD=20) or little/no AD co-pathology (SYN-AD=35). Read More

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December 2018

Coding of Experimental Conditions in Microfluidic Droplet Assays Using Colored Beads and Machine Learning Supported Image Analysis.

Small 2018 Dec 14:e1802384. Epub 2018 Dec 14.

Bio Pilot Plant, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, 07745, Jena, Germany.

To efficiently exploit the potential of several millions of droplets that can be considered as individual bioreactors in microfluidic experiments, methods to encode different experimental conditions in droplets are needed. The approach presented here is based on coencapsulation of colored polystyrene beads with biological samples. The decoding of the droplets, as well as content quantification, are performed by automated analysis of triggered images of individual droplets in-flow using bright-field microscopy. Read More

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December 2018

Surfacing tensions through making explicit our evaluative judgements of research.

Authors:
Rola Ajjawi

Med Educ 2019 Jan;53(1):11-12

Centre for Research in Assessment and Digital Learning, Deakin University, Melbourne, Victoria, Australia.

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January 2019

Applicability of telemedicine in the screening of diabetic retinopathy (DR): The first multicentre study in Italy. The No Blind Study.

Diabetes Metab Res Rev 2018 Dec 13:e3113. Epub 2018 Dec 13.

Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.

Aims: Diabetic retinopathy (DR) represents the main cause of blindness among adults in the industrialized Countries. Use of telemedicine could offer an easy, smart specialist fundus oculi examination, as well as putting in a screening program many patients who otherwise would be excluded.

Materials And Methods: The NO Blind is a transversal, multicentre, observational study. Read More

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December 2018

A study to investigate the impact of a blended learning teaching approach to teach pharmacy law.

Int J Pharm Pract 2018 Dec 13. Epub 2018 Dec 13.

School of Pharmacy, Newcastle University, Newcastle upon Tyne, UK.

Objective: To describe the implementation and assess the effect of a blended learning approach to teach pharmacy law.

Methods: Twenty didactic pharmacy law lectures were redeveloped to 9 h of flipped classroom sessions. Presession online videos delivered factual content created in-house. Read More

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December 2018

How Much Blood Could a JP Suck If a JP Could Suck Blood?

Laryngoscope 2018 Dec 13. Epub 2018 Dec 13.

Department of Otolaryngology Head and Neck Surgery at Chapel Hill, Chapel Hill, North Carolina, U.S.A.

Objective: Active surgical drains minimize fluid accumulation in the postoperative period. The Jackson-Pratt (JP) system consists of a silicone drain connected by flexible tubing to a bulb. When air in the bulb is evacuated, negative pressure is applied at the surgical site to aspirate fluid. Read More

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December 2018

Fully convolutional networks in multimodal nonlinear microscopy images for automated detection of head and neck carcinoma: A pilot study.

Head Neck 2018 Dec 12. Epub 2018 Dec 12.

Department of Otorhinolaryngology, Jena University Hospital, Jena, Germany.

Background: A fully convolutional neural networks (FCN)-based automated image analysis algorithm to discriminate between head and neck cancer and noncancerous epithelium based on nonlinear microscopic images was developed.

Methods: Head and neck cancer sections were used for standard histopathology and co-registered with multimodal images from the same sections using the combination of coherent anti-Stokes Raman scattering, two-photon excited fluorescence, and second harmonic generation microscopy. The images analyzed with semantic segmentation using a FCN for four classes: cancer, normal epithelium, background, and other tissue types. Read More

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December 2018

A parallel Homological Spanning Forest framework for 2D topological image analysis.

Pattern Recognit Lett 2016 Nov;83(1):49-58

Faculty of Mathematics, University of Vienna, Oskar-Morgenstern-Platz 1, Wien A-1090, Austria.

In [14], a topologically consistent framework to support parallel topological analysis and recognition for 2 digital objects was introduced. Based on this theoretical work, we focus on the problem of finding efficient algorithmic solutions for topological interrogation of a 2 digital object of interest of a presegmented digital image , using 4-adjacency between pixels of . In order to maximize the degree of parallelization of the topological processes, we use as many elementary unit processing as pixels the image has. Read More

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November 2016

The Emerging Environmental and Public Health Problem of Electronic Waste in India.

J Health Pollut 2017 Sep 7;7(15):1-7. Epub 2017 Sep 7.

Department of Chemistry, Manav Rachna University, Sector 43, Faridabad, India.

Background: Monumental progress has been made in the area of information and communication technology, leading to a tremendous increase in use of electronic equipment, especially computers and mobile phones. The expansion of production and consumption of electronic equipment along with its shorter life span has led to the generation of tremendous amounts of electronic waste (e-waste). In addition, there is a high level of trans-boundary movement of these devices as second-hand electronic equipment from developed countries, in the name of bridging the digital gap. Read More

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September 2017

Product development of a condenser dosimeter using a skin-insulated USB-A-substrate with a silicon X-ray diode.

Radiol Phys Technol 2018 Dec 13. Epub 2018 Dec 13.

Department of Physics, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba, Iwate, 028-3694, Japan.

To measure integral doses in image-guided radiation therapy, we developed an integral condenser dosimeter comprising a disposable USB-A mini-substrate with a 0.1-µF condenser and a silicon X-ray diode (Si-XD), a microcomputer (mbed) dock, and a personal computer (PC). The Si-XD is a high-sensitivity photodiode selected for detecting X-rays. Read More

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December 2018

Glucagon-like peptide-1 receptor expression after myocardial infarction: Imaging study using Ga-NODAGA-exendin-4 positron emission tomography.

J Nucl Cardiol 2018 Dec 13. Epub 2018 Dec 13.

Turku PET Centre, University of Turku, 20520, Turku, Finland.

Background: Activation of glucagon-like peptide-1 receptor (GLP-1R) signaling protects against cardiac dysfunction and remodeling after myocardial infarction (MI). The aim of the study was to evaluate Ga-NODAGA-exendin-4 positron emission tomography (PET) for assessment of GLP-1R expression after MI in rats.

Methods And Results: Rats were studied at 3 days, 1 and 12 weeks after permanent coronary ligation or a sham-operation. Read More

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December 2018
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3D printing anatomical models of head bones.

Surg Radiol Anat 2018 Dec 13. Epub 2018 Dec 13.

Anatomy Department, Hospital de Santa Maria, Instituto de Anatomia, Faculdade de Medicina da Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028, Lisbon, Portugal.

Purpose: In many medical schools, the study of Anatomy is becoming increasingly theoretical owing to the difficulty of having human body parts available, rather than offering the students the possibility of a more realistic and practical approach. We developed a project where we use a 3D printer to produce models of the human skull bones, with high quality and quantity to satisfy the needs for Anatomy classes and to be available for request to study at home.

Methods: We selected regular and well-shaped bones of the head upon which we based the 3D models. Read More

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December 2018

Decrease in interpretation time for both novice and experienced readers using a concurrent computer-aided detection system for digital breast tomosynthesis.

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

Advanced Medical Device Research Division, Korea Electrotechnology Research Institute, 111 Hanggaul-ro, Sangnok-gu, Ansan-si, Gyeonggi-do, 15588, Republic of Korea.

Objectives: To compare the diagnostic performance and interpretation time of digital breast tomosynthesis (DBT) for both novice and experienced readers with and without using a computer-aided detection (CAD) system for concurrent read.

Methods: CAD system was developed for concurrent read in DBT interpretation. In this observer performance study, we used an enriched sample of 100 DBT cases including 70 with and 30 without breast cancers. Read More

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December 2018

Energy Dispersive X-Ray Fluorescence Zn/Fe Ratiometric Determination of Zinc Levels in Expressed Prostatic Fluid: A Direct, Non-Invasive and Highly Accurate Screening for Prostate Cancer.

Acta Sci Cancer Biol 2018 Nov 10;2(9):20-26. Epub 2018 Oct 10.

The Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Maryland, United States of America.

Prostate specific antigen (PSA) does not provide the reliability that is required for the accurate urology screening of prostate cancer (PCa). Consequently, there has been a major focus and search for a simple, rapid, direct, preferably non-invasive, and highly accurate biomarker and procedure for the urology screening for prostate cancer. Virtually all PCa cases exhibit a marked decrease in zinc in prostate tissue and in prostatic fluid. Read More

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November 2018

Design of a 3D navigation template to guide the screw trajectory in spine: a step-by-step approach using Mimics and 3-Matic software.

J Spine Surg 2018 Sep;4(3):645-653

Department of Spine Surgery, Digital Orthopedic Institute, Orthopedic Hospital, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Second Medical College of Wenzhou Medical University, Zhejiang Spine Surgery Center, Wenzhou 325027, China.

Rapid development of 3D printing techniques has led to the design of navigation templates to assist with accurate insertion of pedicle screws in last decades. However, there are still without the precise step-by-step methods to design 3D navigation templates from computed tomography (CT) images. Our present article provides a detailed protocol to allow the readers or researchers to obtain the 3D navigation template easily, and assist with pedicle screw insertion in their future research and surgery. Read More

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September 2018

Bilateral Fracture of the Handle Malleus: A Case Report and Review of the Literature.

J Clin Imaging Sci 2018 15;8:49. Epub 2018 Nov 15.

Department of Radiology, Division of Neuroradiology, University of Michigan Health System. Ann Arbor, Michigan, USA.

Malleus fracture is a rare condition. Usually, the handle of the malleus is involved, and we do not find reports in the literature of this condition in the bilateral presentation. It is present as sudden conductive hearing loss commonly after digital manipulation of the external auditory canal. Read More

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November 2018

Evaluation of prostate-specific antigen density in the diagnosis of prostate cancer combined with magnetic resonance imaging before biopsy in men aged 70 years and older with elevated PSA.

Mol Clin Oncol 2018 Dec 19;9(6):656-660. Epub 2018 Sep 19.

Department of Urology, Keio University School of Medicine, Tokyo 160-8582, Japan.

There is an increasing proportion of individuals aged 70 years and older, as well as an increasing life expectancy worldwide. The present study may guide the management of older patients with elevated prostate specific antigen (PSA). The medical records of 241 older men aged >70 years who underwent multiparametric magnetic resonance imaging (mpMRI) before prostate biopsy (PBx) at our institution were reviewed retrospectively. Read More

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December 2018

Identification of rare levels of methylated tumor DNA fragments using an optimized bias based pre-amplification-digital droplet PCR (OBBPA-ddPCR).

Oncotarget 2018 Nov 16;9(90):36137-36150. Epub 2018 Nov 16.

Institute of Clinical Chemistry and Laboratory Medicine, Carl Gustav Carus University Hospital, Technical University of Dresden, Dresden, Germany.

Background: The analysis of aberrant DNA methylations is used for the diagnosis of cancer as significant changes in the gene methylation pattern are often detected during early carcinogenesis. In this study, we evaluated the performance of a two-step method that combines pre-amplification with ddPCR technique.

Results: By using ddPCR, the dependence of amplification efficiency for methylated and unmethylated DNA fragments on the relevant MgCl concentration and the annealing temperature was established in addition to the primer design. Read More

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November 2018

The Over-Extended Mind? Pink Noise and the Ethics of Interaction-Dominant Systems.

Nanoethics 2018 1;12(3):269-281. Epub 2018 Nov 1.

4Department of Health and Social Sciences, UWE, Bristol, Coldharbour Lane, Bristol, BS16 1QY UK.

There is a growing recognition within cognitive enhancement and neuroethics debates of the need for greater emphasis on cognitive artefacts. This paper aims to contribute to this broadening and expansion of the cognitive-enhancement and neuroethics debates by focusing on a particular form of relation or coupling between humans and cognitive artefacts: interaction-dominance. We argue that interaction-dominance as an emergent property of some human-cognitive artefact relations has important implications for understanding the attribution and distribution of causal and other forms of responsibility as well as agency relating to the actions of human-cognitive artefact couplings. Read More

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November 2018

Reliability and accuracy of linear measurements in cone-beam computed tomography using different software programs and voxel sizes.

J Conserv Dent 2018 Nov-Dec;21(6):607-612

Department of Dentistry, State University of Maringá, Maringá, PR, Brazil.

Objectives: The aim of this study is to evaluate the accuracy of linear measurements on cone-beam computed tomography (CBCT) images using three software programs and different voxel sizes.

Methods: Ten human mandibles with 25 silica markers were scanned for 0.250-, 0. Read More

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December 2018
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REASSURED diagnostics to inform disease control strategies, strengthen health systems and improve patient outcomes.

Nat Microbiol 2019 Jan 13;4(1):46-54. Epub 2018 Dec 13.

London School of Hygiene and Tropical Medicine, London, England.

Lack of access to quality diagnostics remains a major contributor to health burden in resource-limited settings. It has been more than 10 years since ASSURED (affordable, sensitive, specific, user-friendly, rapid, equipment-free, delivered) was coined to describe the ideal test to meet the needs of the developing world. Since its initial publication, technological innovations have led to the development of diagnostics that address the ASSURED criteria, but challenges remain. Read More

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January 2019

Use of the Normalized Difference Road Landside Index (NDRLI)-based method for the quick delineation of road-induced landslides.

Sci Rep 2018 Dec 13;8(1):17815. Epub 2018 Dec 13.

Key Laboratory of Environment Change and Resources Use in Beibu Gulf, Ministry of Education, Guangxi Teachers Education University, 175 Mingxiu East St., Nanning, 530001, China.

Recognition and classification of road-related landslides are a critical requirement in pre- and post-disaster hazard analysis. They are primarily done through field mapping or manual image interpretation from commercial satellites images. This paper developed a Normalized Difference Road Landside Index (NDRLI)-based method to delineate road-induced landslides and enhance their presence in remotely sensed digital imagery based on free Landsat Operational Land Imager (OLI) sources. Read More

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December 2018

Elements of Trust in Digital Health Systems: Scoping Review.

J Med Internet Res 2018 Dec 13;20(12):e11254. Epub 2018 Dec 13.

Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.

Background: Information and communication technologies have long become prominent components of health systems. Rapid advances in digital technologies and data science over the last few years are predicted to have a vast impact on health care services, configuring a paradigm shift into what is now commonly referred to as digital health. Forecasted to curb rising health costs as well as to improve health system efficiency and safety, digital health success heavily relies on trust from professional end users, administrators, and patients. Read More

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December 2018
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