15,358 results match your criteria Digestive diseases and sciences[Journal]


Impact of Urgent Double-Balloon Enteroscopy on the Short-Term and Long-Term Outcomes in Overt Small Bowel Bleeding.

Dig Dis Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology, Sendai Kousei Hospital, Sendai, 980-0873, Japan.

Background: Double-balloon enteroscopy (DBE) is a safe and useful procedure for managing small bowel bleeding. However, there are limited studies regarding the preferable timing of DBE and its impact on long-term outcomes.

Aim: We aimed to evaluate the association between the timing of DBE and the long-term outcomes of patients suspected of having overt small bowel bleeding who underwent DBE. Read More

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http://dx.doi.org/10.1007/s10620-019-05627-1DOI Listing

Comprehensive Analysis of the Canonical and Non-canonical Wnt Signaling Pathways in Gastric Cancer.

Dig Dis Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Otolaryngology, Xi'an No.4 Hospital, No. 21 Jiefang Road, Xi'an, 710004, Shaanxi, China.

Background: Previous studies showed that dysregulation of Wnt signaling by gene mutation and abnormal gene expression is one of the causative factors for gastric cancer (GC). So far, a systematic and comprehensive analysis of gene mutation, gene expression, and DNA methylation profiles of the Wnt pathway associated with gastric carcinogenesis, however, has not yet been reported.

Aims: To this end, we investigated all the above-mentioned genetic alterations associated with the canonical and non-canonical Wnt pathways in GC tumors, in order to understand the molecular mechanism underlying gastric carcinogenesis. Read More

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http://dx.doi.org/10.1007/s10620-019-05606-6DOI Listing

Involvement of EP2 and EP4 Receptors in Eosinophilic Esophagitis: A Pilot Study.

Dig Dis Sci 2019 Apr 15. Epub 2019 Apr 15.

Otto Loewi Research Center, Divison of Pharmacology, Medical University of Graz, Universitätsplatz 4, 8010, Graz, Austria.

Background: The prostaglandin D receptor DP2 has been implicated in eosinophil infiltration and the development of eosinophilic esophagitis (EoE).

Aims And Methods: In this study, we investigated an involvement of PGE (EP1-EP4) and PGD (DP1) receptors in EoE by measuring their expression in peripheral blood eosinophils and esophageal mucosal biopsies of EoE patients and by performing migration and adhesion assays with eosinophils from healthy donors.

Results: Expression of EP2 and EP4, but not EP1 and EP3, was decreased in blood eosinophils of patients with EoE vs. Read More

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http://dx.doi.org/10.1007/s10620-019-05623-5DOI Listing

Recent Advances in Prevention and Therapies for Clinical or Experimental Necrotizing Enterocolitis.

Dig Dis Sci 2019 Apr 15. Epub 2019 Apr 15.

Department of Surgery, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Necrotizing enterocolitis (NEC) is one of the most severe diseases of preterm neonates and has a high mortality rate. With the development of inspection techniques and new biomarkers, the diagnostic accuracy of NEC is constantly improving. The most recognized potential risk factors include prematurity, formula-feeding, infection, and microbial dysbiosis. Read More

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http://dx.doi.org/10.1007/s10620-019-05618-2DOI Listing

Role of Spleen Stiffness Measurement by 2D-Shear Wave Elastography in Ruling Out the Presence of High-Risk Varices in Cirrhotic Patients.

Dig Dis Sci 2019 Apr 15. Epub 2019 Apr 15.

Academic Department of Gastroenterology, Laiko General Hospital, Medical School of National, Kapodistrian University of Athens, 17 Aghiou Thoma, 11527, Athens, Greece.

Background And Aim: To evaluate if spleen stiffness measurement (SSM) can rule out the presence of high-risk varices in patients with cirrhosis, avoiding an upper gastrointestinal endoscopy (UGE).

Methods: We enrolled 71 cirrhotic patients irrespective of liver disease's etiology. 2D shear wave elastography (SWE) of spleen and UGE was performed. Read More

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http://dx.doi.org/10.1007/s10620-019-05616-4DOI Listing

The Proton Pump Inhibitor Lansoprazole Has Hepatoprotective Effects in In Vitro and In Vivo Rat Models of Acute Liver Injury.

Dig Dis Sci 2019 Apr 15. Epub 2019 Apr 15.

Department of Surgery, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.

Background/aims: The proton pump inhibitor lansoprazole (LPZ) is clinically used to reduce gastric acid secretion, but little is known about its possible hepatoprotective effects. This study aimed to investigate the hepatoprotective effects of LPZ and its potential mechanisms using in vitro and in vivo rat models of liver injury.

Methods: For the in vitro model of liver injury, primary cultured rat hepatocytes were treated with interleukin-1β in the presence or absence of LPZ. Read More

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http://dx.doi.org/10.1007/s10620-019-05622-6DOI Listing

Eosinophilic Gastroenteritis: Clinical Manifestation, Natural Course, and Evaluation of Treatment with Corticosteroids and Vedolizumab.

Dig Dis Sci 2019 Apr 13. Epub 2019 Apr 13.

Department of Gastroenterology and Hepatology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.

Background: Eosinophilic gastroenteritis (EGE) is a rare, chronic inflammatory condition of the gastrointestinal tract. Little is known about its natural history and treatment outcomes. The aims of our analysis were to describe clinical presentation, response to current medical treatments, and to evaluate the response of refractory EGE to anti-integrin therapy. Read More

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http://dx.doi.org/10.1007/s10620-019-05617-3DOI Listing
April 2019
2 Reads

Clinical Predictors of Rapid Gastric Emptying in Patients Presenting with Dyspeptic Symptoms.

Dig Dis Sci 2019 Apr 13. Epub 2019 Apr 13.

Digestive Diseases and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: Rapid gastric emptying (RGE) is defined as less than 30% retention at 1 h of solid meal ingestion. It is unclear whether RGE represents a separated clinical entity or part of the functional dyspepsia spectrum.

Aims: To determine clinical predictors of RGE in patients presenting with dyspeptic symptoms. Read More

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http://dx.doi.org/10.1007/s10620-019-05620-8DOI Listing

Minichromosomal Maintenance Component Complex 5 (MCM5) as a Marker of Barrett's Esophagus-Related Neoplasia: A Feasibility Study.

Dig Dis Sci 2019 Apr 13. Epub 2019 Apr 13.

Division of Surgery and Interventional Science, University College London, London, UK.

Background: The endoscopic detection of esophageal cancer is suboptimal in both patients referred with dyspeptic symptoms and those enrolled in Barrett's surveillance programs. MCM5 expression in cells collected from gastric fluid may be correlated with the presence of dysplasia or adenocarcinoma. Analysis of this biomarker may improve the detection of cancer. Read More

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http://dx.doi.org/10.1007/s10620-019-05607-5DOI Listing

Early Hepatitis B Surface Antigen Seroclearance Following Antiviral Treatment in Patients with Reactivation of Resolved Hepatitis B.

Dig Dis Sci 2019 Apr 13. Epub 2019 Apr 13.

Division of Hematology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background And Aims: Long-term results on hepatitis B virus (HBV) reactivation in patients with resolved infection during anti-cancer therapy are unknown. This study investigated long-term risk and therapeutic endpoints including hepatitis B surface antigen (HBsAg) seroclearance following antiviral therapy in patients developing reactivation of resolved HBV.

Methods: The study included 528 consecutive HBsAg-negative/hepatitis B core antibody-positive patients who underwent rituximab treatment or hematopoietic stem cell transplantation (HSCT) between 2006 and 2016. Read More

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http://link.springer.com/10.1007/s10620-019-05614-6
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http://dx.doi.org/10.1007/s10620-019-05614-6DOI Listing
April 2019
6 Reads
2.550 Impact Factor

Therapeutic Efficacy and Adverse Events of Tacrolimus in Patients with Crohn's Disease: Systematic Review and Meta-Analysis.

Dig Dis Sci 2019 Apr 13. Epub 2019 Apr 13.

Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Minami 1-jo Nishi 16-chome, Chuo-ku, Sapporo, Hokkaido, 060-8543, Japan.

Background: Only a few randomized controlled trials (RCTs) and some uncontrolled trials have reported the efficacy and adverse events (AEs) of tacrolimus (Tac) in patients with refractory Crohn's disease (CD). The aim of this study was to undertake a systematic review and meta-analysis of the therapeutic efficacy and AEs of Tac in patients with CD.

Methods: We investigated studies reporting the therapeutic efficacy of Tac in patients with CD from 1950 until December 2017. Read More

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http://dx.doi.org/10.1007/s10620-019-05619-1DOI Listing

Optimal Timing of Simethicone Addition for Bowel Preparation Using Polyethylene Glycol Plus Ascorbic Acid.

Dig Dis Sci 2019 Apr 11. Epub 2019 Apr 11.

Department of Internal Medicine, Digestive Disease Center and Research Institute, SoonChunHyang University School of Medicine, SoonChunHyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon and Seoul, 420-767, Korea.

Background: Colonic bubbles obscure the colonic mucosa during colonoscopy following bowel preparation with polyethylene glycol plus ascorbic acid (PEG-Asc). Simethicone is used to enhance visualization during colonoscopy. We aimed to determine the optimal timing of simethicone addition to improve bowel preparation using PEG-Asc. Read More

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http://dx.doi.org/10.1007/s10620-019-05599-2DOI Listing
April 2019
2.550 Impact Factor

Obesity and the Risk of Gastrointestinal Cancers.

Dig Dis Sci 2019 Apr 9. Epub 2019 Apr 9.

Department of Gastroenterology, Human Nutrition and Internal Medicine, Poznan University of Medical Sciences, Fredry 10, 61-701, Poznan, Poland.

Obesity is a risk factor for all major gastrointestinal cancers. With the rapid increase in the prevalence of obesity worldwide, this link could lead to an elevated burden of cancers of the digestive system. Currently, three main mechanisms explaining the link between excess adiposity and gastrointestinal cancer risk are being considered, including altered insulin signaling, obesity-associated chronic low-grade inflammation, and altered sex hormone metabolism, although new potential mechanisms emerge. Read More

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http://dx.doi.org/10.1007/s10620-019-05603-9DOI Listing
April 2019
2 Reads

Under Pressure: Do Volume-Based Measurements Define Rectal Hyposensitivity in Clinical Practice?

Dig Dis Sci 2019 Apr 8. Epub 2019 Apr 8.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 300 Pasteur Drive, MC 5244, Stanford, CA, 94305, USA.

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http://dx.doi.org/10.1007/s10620-019-05613-7DOI Listing

Open Access Colonoscopy for Colorectal Cancer Prevention: An Evaluation of Appropriateness and Quality.

Dig Dis Sci 2019 Apr 6. Epub 2019 Apr 6.

Department of Gastroenterology, Cleveland Clinic Florida, 2950 Cleveland Clinic Boulevard, Weston, FL, USA.

Background: Open access colonoscopy (OAC) has gained widespread acceptance and has the potential to increase colorectal cancer (CRC) screening. However, there is little data evaluating its appropriateness for CRC prevention.

Aims: The aim of this study is to evaluate the appropriateness of OAC in CRC screening and polyp surveillance by comparing to procedures ordered by gastroenterologists (NOAC). Read More

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http://dx.doi.org/10.1007/s10620-019-05612-8DOI Listing
April 2019
1 Read

Chronic Megacolon Presenting in Adolescents or Adults: Clinical Manifestations, Diagnosis, and Genetic Associations.

Dig Dis Sci 2019 Apr 5. Epub 2019 Apr 5.

Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Division of Gastroenterology and Hepatology, Mayo Clinic, Charlton Bldg., Rm. 8-110, 200 First Street S.W., Rochester, MN, 55905, USA.

Objective: Chronic megacolon is rarely encountered in clinical practice beyond infancy or early childhood. Most cases are sporadic, and some are familial megacolon and present during adolescence or adulthood. There is a need for diagnostic criteria and identifying genetic variants reported in non-Hirschsprung's megacolon. Read More

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http://dx.doi.org/10.1007/s10620-019-05605-7DOI Listing

Overexpression of PARPBP Correlates with Tumor Progression and Poor Prognosis in Hepatocellular Carcinoma.

Dig Dis Sci 2019 Apr 4. Epub 2019 Apr 4.

Department of Hepatobiliary and Laparoscopic Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, People's Republic of China.

Background: PARP1-binding protein (PARPBP/PARI/C12orf48), a negative regulator of homologous recombination (HR), has been suggested to function as an oncogene in cervical, lung, and pancreatic cancer.

Objective: To investigate the expression profile of PARPBP and its role in hepatocellular carcinoma (HCC).

Methods: Using data from the Cancer Genome Atlas and Human Protein Atlas databases, PARPBP expression level and its clinical implication in HCC were identified by t test and Chi-square test. Read More

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http://dx.doi.org/10.1007/s10620-019-05608-4DOI Listing
April 2019
3 Reads

Milking the System: Dietary Therapy of Post-nephrectomy Chylous Ascites.

Dig Dis Sci 2019 Apr 4. Epub 2019 Apr 4.

Division of Gastroenterology and Hepatology, University of New Mexico School of Medicine Medical Center, MSC 10-5550, 1, Albuquerque, NM, USA.

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http://dx.doi.org/10.1007/s10620-019-05611-9DOI Listing
April 2019
1 Read

Effects and Mechanism of Constitutive TL1A Expression on Intestinal Mucosal Barrier in DSS-Induced Colitis.

Dig Dis Sci 2019 Apr 4. Epub 2019 Apr 4.

Department of Gastroenterology, The Second Hospital of Hebei Medical University, No. 80 Huanghe Road, Yuhua District, Shijiazhuang, 050000, Hebei, China.

Objective: The role of TL1A in the intestinal mucosa barrier in inflammatory bowel disease (IBD) is still unclear. This study was aimed to investigate the expression levels of tight junction protein (TJ), myosin light chain kinase (MLCK), MyD88 and tumor necrosis factor (TNF) receptor-associated factor-6 (TRAF6) and how TL1A influences the intestinal barrier in IBD.

Methods: The mouse models of IBD were built using FMS-TL1A-GFP-transgenic mice and wild-type mice. Read More

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http://link.springer.com/10.1007/s10620-019-05580-z
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http://dx.doi.org/10.1007/s10620-019-05580-zDOI Listing
April 2019
3 Reads

α7-Nicotinic Acetylcholine Receptor Promotes Cholangiocarcinoma Progression and Epithelial-Mesenchymal Transition Process.

Dig Dis Sci 2019 Apr 4. Epub 2019 Apr 4.

Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, 266003, Shandong, China.

Background: Cholangiocarcinoma is one of the most deadly malignant tumors characterized by a tendency of local invasiveness and metastasis at the early phase, high recurrence rate, and difficulty in treatment. Alpha7-nicotinic acetylcholine receptor (α7-nAChR) is highly expressed in a variety of tumors, including cholangiocarcinoma, and may promote tumor progression, but the mechanisms are largely unknown.

Aims: Our study is the first to expound upon the role that α7-nAChR plays in cholangiocarcinoma. Read More

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http://dx.doi.org/10.1007/s10620-019-05609-3DOI Listing
April 2019
1 Read

Improved Antibody Response to Three Additional Hepatitis B Vaccine Doses Following Primary Vaccination Failure in Patients with Inflammatory Bowel Disease.

Dig Dis Sci 2019 Apr 3. Epub 2019 Apr 3.

Section of Gastroenterology, Boston University Medical Center, 85 East Concord Street, Boston, MA, 02118, USA.

Background: Studies have shown the efficacy of hepatitis B (HBV) vaccination in patients with inflammatory bowel disease (IBD) is impaired, but few data exist regarding the effectiveness of revaccination strategies following primary vaccination failure. Our aim was to analyze the association between administration of additional vaccine doses and hepatitis B surface antibody (HBsAb) seroconversion.

Methods: This is a retrospective cohort study. Read More

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http://dx.doi.org/10.1007/s10620-019-05595-6DOI Listing
April 2019
1 Read

Can Sertraline and Nortriptyline Protect the Neurons in Submucosal and Myenteric Plexuses of Rat's Colon Against Stress?

Dig Dis Sci 2019 Apr 1. Epub 2019 Apr 1.

Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Zand Ave., Shiraz, 71348-45794, Iran.

Background: The colon is partly controlled by myenteric and submucosal plexuses, which respond to stress and lead to some gastrointestinal disorders. These plexuses play roles in irritable bowel syndrome. Patients suffering from this syndrome can be treated with some antidepressants, including sertraline and nortriptyline. Read More

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http://dx.doi.org/10.1007/s10620-019-05600-yDOI Listing

Role of Liver Stiffness Measurement in Predicting HCC Occurrence in Direct-Acting Antivirals Setting: A Real-Life Experience.

Dig Dis Sci 2019 Apr 1. Epub 2019 Apr 1.

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Piazza Miraglia, 80138, Naples, Italy.

Purpose: The aim of this study was to evaluate the relationship between the liver stiffness measurement and the risk of developing hepatocellular carcinoma (HCC) in HCV cirrhotic patients undergoing new direct-acting antivirals.

Methods: From April 2015 to April 2017, all consecutive HCV cirrhotic patients treated by direct-acting antivirals were enrolled. A liver stiffness measurement was computed at baseline, and an ultrasound evaluation was provided for all patients at baseline and every 6 months until 1 year after the stopping of the antiviral therapy. Read More

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http://dx.doi.org/10.1007/s10620-019-05604-8DOI Listing
April 2019
1 Read

Early Endoscopy Is Associated with Better Clinical Outcomes in Patients Hospitalized with Ischemic Bowel Disease.

Dig Dis Sci 2019 Mar 30. Epub 2019 Mar 30.

Department of Medicine, North Shore Medical Center, Salem, MA, USA.

Background And Aims: Providing diagnostic and therapeutic interventions, lower gastrointestinal endoscopy is a salient investigative modality for ischemic bowel disease (IB). As studies on the role of endoscopic timing on the outcomes of IB are lacking, we sought to clarify this association.

Methods: After identifying 18-to-90-year-old patients with a primary diagnosis of IB from the 2012-2014 Healthcare Cost and Utilization Project-Nationwide Inpatient Sample, we grouped them based on timing of endoscopy into three: early (n = 9268), late (n = 3515), and no endoscopy (n = 18,452). Read More

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http://link.springer.com/10.1007/s10620-019-05598-3
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http://dx.doi.org/10.1007/s10620-019-05598-3DOI Listing
March 2019
8 Reads

Illuminating Elimination Diets: Controversies Regarding Dietary Treatment of Eosinophilic Esophagitis.

Dig Dis Sci 2019 Mar 29. Epub 2019 Mar 29.

Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing and Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, UNC-CH, CB#7080, Bioinformatics Building, 130 Mason Farm Rd., Chapel Hill, NC, 27599-7080, USA.

Eosinophilic esophagitis (EoE) is an immune-mediated disease triggered by food antigens for which dietary elimination treatment can induce and sustain histologic remission. Our review aims to describe the state of the art regarding dietary treatment of EoE, highlighting a number of areas of controversy related to dietary therapy in EoE, including novel modalities for determining food triggers, making the empiric dietary elimination process more efficient, issues of cross-contamination and "dosing" of how much food to avoid or add back, costs and effects on quality of life, long-term efficacy, and the risk of developing immediate IgE-type reactions after initial dietary elimination. Elemental formulas, empiric elimination diets, and targeted allergy test-directed elimination diets are well-described treatments for EoE. Read More

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http://dx.doi.org/10.1007/s10620-019-05602-wDOI Listing
March 2019
1 Read

Integrin Calculus: The Predictive Power of Vedolizumab Concentrations in IBD Therapy.

Dig Dis Sci 2019 Mar 29. Epub 2019 Mar 29.

Center for Inflammatory Bowel Diseases, Division of Gastroenterology, Beth-Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Rabb 425, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s10620-019-05601-xDOI Listing

Importance of Hepatitis C Virus RNA Testing in Patients with Suspected Drug-Induced Liver Injury.

Dig Dis Sci 2019 Mar 29. Epub 2019 Mar 29.

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, USA.

Background And Aims: The aims were to review the diagnosis, testing and presentation of acute hepatitis C (HCV) in patients initially diagnosed to have drug-induced liver injury (DILI) enrolled in the US DILI Network.

Methods: All patients with suspected DILI underwent testing for competing causes of liver injury and returned for 6-month follow-up. Causality was adjudicated by consensus expert opinion. Read More

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http://link.springer.com/10.1007/s10620-019-05591-w
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http://dx.doi.org/10.1007/s10620-019-05591-wDOI Listing
March 2019
1 Read

Market Access Analysis of Biologics and Small-Molecule Inhibitors for Inflammatory Bowel Disease Among US Health Insurance Policies.

Dig Dis Sci 2019 Mar 28. Epub 2019 Mar 28.

Division of Gastroenterology, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, USA.

Background And Aims: Treatment pathways for ulcerative colitis (UC) and Crohn's disease (CD) are shifting to a more individualized, risk-stratified approach. The perception is that insurance policies may not have implemented this paradigm shift, particularly regarding access to newer agents. We evaluated patient access to advanced therapies by analyzing policy information from the Managed Markets Insight and Technology database. Read More

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http://dx.doi.org/10.1007/s10620-019-05594-7DOI Listing
March 2019
1 Read

Capsule-Delivered Fecal Microbiota Transplant Is Safe and Well Tolerated in Patients with Ulcerative Colitis.

Dig Dis Sci 2019 Mar 27. Epub 2019 Mar 27.

Division of Gastroenterology, Department of Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA, 94143, USA.

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http://dx.doi.org/10.1007/s10620-019-05596-5DOI Listing

Mailed Outreach Is Superior to Usual Care Alone for Colorectal Cancer Screening in the USA: A Systematic Review and Meta-analysis.

Dig Dis Sci 2019 Mar 26. Epub 2019 Mar 26.

Moores Cancer Center, UC San Diego, San Diego, USA.

Mailed outreach promoting colorectal cancer (CRC) screening with a stool blood test kit may increase participation, but magnitude and consistency of benefit of this intervention strategy is uncertain. Our aim was to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing mailed outreach offering stool tests to usual care, clinic-based screening offers on CRC screening uptake in the USA. We performed a systematic literature search of five databases for RCTs of mailed outreach from January 1980 through June 2017. Read More

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http://dx.doi.org/10.1007/s10620-019-05587-6DOI Listing

Thromboelastography Parameters Are Associated with Cirrhosis Severity.

Dig Dis Sci 2019 Mar 26. Epub 2019 Mar 26.

Division of Gastroenterology and Hepatology, University of Washington Medical Center, University of Washington, 1959 NE Pacific Street, Box 356175, Seattle, WA, 98195, USA.

Background: Coagulopathy in cirrhosis represents complex coagulation derangements, and thromboelastography (TEG) measures these complex derangements.

Aim: We sought to evaluate associations between TEG parameters and validated measures of cirrhosis severity, which have not been previously investigated.

Materials And Methods: Adults with cirrhosis undergoing liver transplant (LT) were identified. Read More

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http://dx.doi.org/10.1007/s10620-019-05597-4DOI Listing
March 2019
1 Read
2.550 Impact Factor

Aberrant p53 Immunostaining in Barrett's Esophagus Predicts Neoplastic Progression: Systematic Review and Meta-Analyses.

Dig Dis Sci 2019 Mar 26. Epub 2019 Mar 26.

Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, 3500 Gaston Avenue, Dallas, TX, 75246, USA.

Risk stratification of patients with Barrett's esophagus (BE) presently relies on the histopathologic grade of dysplasia found in esophageal biopsies, which is limited by sampling error and inter-pathologist variability. p53 immunostaining of BE biopsies has shown promise as an adjunct tool but is not recommended by American gastroenterology societies, who cite insufficient evidence of its prognostic value. We have conducted a systematic review and meta-analyses to clarify this value. Read More

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http://dx.doi.org/10.1007/s10620-019-05586-7DOI Listing

Radiation Training, Radiation Protection, and Fluoroscopy Utilization Practices Among US Therapeutic Endoscopists.

Dig Dis Sci 2019 Mar 25. Epub 2019 Mar 25.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 300 Pasteur Drive, MC 5244, Stanford, CA, 94305, USA.

Background: Fluoroscopy use during ERCP exposes patients and providers to deleterious effects of radiation. Formal training in fluoroscopy/radiation protection is not widely emphasized during therapeutic endoscopy training, and radiation use during GI endoscopy has not previously been characterized in the USA. In this study, we evaluated radiation training, fluoroscopy use patterns, and radiation protection practices among US therapeutic endoscopists. Read More

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http://link.springer.com/10.1007/s10620-019-05564-z
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http://dx.doi.org/10.1007/s10620-019-05564-zDOI Listing
March 2019
5 Reads

Diagnostic and Therapeutic Delays in the Management of Postoperative Crohn's Disease.

Dig Dis Sci 2019 Mar 22. Epub 2019 Mar 22.

Division of Gastroenterology, IBD Center, Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.

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http://dx.doi.org/10.1007/s10620-019-05592-9DOI Listing
March 2019
1 Read

Determinants of Hepatitis C Treatment Adherence and Treatment Completion Among Veterans in the Direct Acting Antiviral Era.

Dig Dis Sci 2019 Mar 22. Epub 2019 Mar 22.

VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.

Background: Despite the availability of direct acting antiviral medications (DAAs), there are ongoing concerns about adherence to hepatitis C virus (HCV) treatment. We sought to understand the barriers to and facilitators of DAA adherence in the Veteran population.

Methods: Patients completed semi-structured interviews focused on barriers to and facilitators of HCV treatment adherence both pre- and post-DAA treatment. Read More

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http://dx.doi.org/10.1007/s10620-019-05590-xDOI Listing

Living Donor Liver Transplantation for Hepatocellular Carcinoma: An Asian Perspective.

Dig Dis Sci 2019 Apr;64(4):993-1000

Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Korea.

Despite advancements in early diagnosis and medico-surgical treatment, hepatocellular carcinoma (HCC) is still a major cancer that causes substantial mortality in Asian countries. Liver transplantation (LT) has been accepted worldwide as the most effective treatment modality for patients with HCC; however, with the high incidence of HCC and low organ donation rate, Asia has developed distinctive features of indications and strategies for the application of LT. Unlike Western countries, living donor liver transplantation (LDLT) accounts for most LT cases for HCC in Asian countries, and most major transplantation centers perform LDLT for HCC patients with extended criteria. Read More

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http://dx.doi.org/10.1007/s10620-019-05551-4DOI Listing

Liver Allocation Policies in the USA: Past, Present, and the Future.

Dig Dis Sci 2019 Apr;64(4):985-992

Center for Liver Diseases, University of Chicago Medicine, 5841 S. Maryland Ave. |MC 7120|, Chicago, IL, 60637, USA.

Identifying the optimal allocation policy with regard to hepatocellular carcinoma has been a persistent and evolving challenge. The current criteria for LT for HCC endorsed by the United Network of Organ Sharing (UNOS) are based on the Milan Criteria: a solitary tumor < 5 cm, or maximum of three tumors ≤ 3 cm each, without vascular invasion or evidence of extrahepatic spread. Contraindications to HCC exception points include: stage 1 HCC, ruptured HCC, extrahepatic HCC, and main portal or hepatic vein HCC invasion. Read More

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http://dx.doi.org/10.1007/s10620-019-05549-yDOI Listing

Multidisciplinary Approach to HCC Management: How Can This Be Done?

Dig Dis Sci 2019 Apr;64(4):968-975

Department of Medicine, Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, 7th Floor, 3400 Civic Center Drive, Philadelphia, PA, 19104, USA.

Multidisciplinary tumor boards have evolved to address the increasing complexity of cancer care management. Given that hepatocellular carcinoma (HCC) often arises in the setting of underlying cirrhosis, expert input from hepatologists alongside hepatobiliary and transplant surgeons, radiation oncologists, interventional and body radiologists, and medical oncologists has become increasingly important in order to offer patients appropriate cancer treatments. The MDLTB structure has evolved since the early 2000s to bring these specialists together at regularly scheduled meetings to develop a therapeutic treatment plan for HCC management. Read More

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http://dx.doi.org/10.1007/s10620-019-05593-8DOI Listing

Biliary Strictures After Liver Transplantation with Grafts from Donors After Cardiac Death: Narrowing Down the Etiologies.

Dig Dis Sci 2019 Mar 18. Epub 2019 Mar 18.

Department of Medicine, Division of Gastroenterology and Hepatology, Virginia Commonwealth University, Richmond, VA, USA.

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http://link.springer.com/10.1007/s10620-019-05589-4
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http://dx.doi.org/10.1007/s10620-019-05589-4DOI Listing
March 2019
2 Reads

Systemic Management for Advanced Hepatocellular Carcinoma: A Review of the Molecular Pathways of Carcinogenesis, Current and Emerging Therapies, and Novel Treatment Strategies.

Dig Dis Sci 2019 Apr;64(4):1016-1029

Section of Digestive Diseases, Department of Internal Medicine, Yale School of Medicine, 1080 LMP, PO Box 208019, New Haven, CT, 06520-8019, USA.

Hepatocellular carcinoma (HCC) arises from a number of cirrhosis-related and non-cirrhosis-related exposures and is one of the leading causes of cancer-related deaths worldwide. Achieving a durable cure currently relies on either resection or transplantation, but since most patients will be diagnosed with inoperable disease, there is great interest in achieving more effective systemic therapies. At a molecular level, HCC is heterogeneous, but initial treatment strategies, including the use of multi-targeted tyrosine kinase inhibitors and checkpoint inhibitors, have been fairly homogenous, depending on general host factors and overall tumor burden rather than specific molecular signatures. Read More

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http://link.springer.com/10.1007/s10620-019-05582-x
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http://dx.doi.org/10.1007/s10620-019-05582-xDOI Listing
April 2019
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In the ZOne: How Impedance Facilitates Progress in Functional Dyspepsia Research.

Dig Dis Sci 2019 Mar 18. Epub 2019 Mar 18.

Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia.

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http://dx.doi.org/10.1007/s10620-019-05575-wDOI Listing

Improving Anemia in Inflammatory Bowel Disease: Impact of the Anemia Care Pathway.

Dig Dis Sci 2019 Mar 16. Epub 2019 Mar 16.

Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Blvd, Houston, TX, 77030, USA.

Background: Anemia is a common complication of inflammatory bowel disease (IBD). Despite existing guidelines for anemia in IBD, it is frequently under-treated and the prevalence of anemia has remained high. To address this gap, the Crohn's and Colitis Foundation developed the Anemia Care Pathway (ACP). Read More

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http://dx.doi.org/10.1007/s10620-019-05559-wDOI Listing
March 2019
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2.550 Impact Factor

WDR34 Activates Wnt/Beta-Catenin Signaling in Hepatocellular Carcinoma.

Dig Dis Sci 2019 Mar 15. Epub 2019 Mar 15.

Department of Hepatobiliary and Pancreatic Surgery, Huai'an First People's Hospital, Nanjing Medical University, 6 Beijing Road West, Huai'an, 223300, Jiangsu Province, People's Republic of China.

Background: Wnt ligand binding initiates the interaction between Frizzled and Dvl proteins. However, the regulation of Frizzled-Dvl proteins interaction remains largely unknown.

Aims: The present study aims to elucidate the regulation of Frizzled-Dvl interaction by WDR34. Read More

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http://dx.doi.org/10.1007/s10620-019-05583-wDOI Listing
March 2019
2.550 Impact Factor

Patient-Initiated Colonoscopy Scheduling Effectively Increases Colorectal Cancer Screening Adherence.

Dig Dis Sci 2019 Mar 15. Epub 2019 Mar 15.

Department of Gastroenterology and Hepatology, Digestive Disease and Surgical Institute, The Cleveland Clinic, 9500 Euclid Avenue/A30, Cleveland, OH, 44195, USA.

Background And Aim: We identified patients without medical record evidence of up-to-date colorectal cancer (CRC) screening and sent an invitation letter to self-schedule a colonoscopy without requiring prior primary care or gastroenterologist consultation. The aim of the study was to evaluate the response rate to the letter and factors associated with colonoscopy completion.

Methods: A computer algorithm invited patients not up to date with CRC screening, with an INR < 1. Read More

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http://link.springer.com/10.1007/s10620-019-05584-9
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http://dx.doi.org/10.1007/s10620-019-05584-9DOI Listing
March 2019
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Coexistence of Alterations of Gastrointestinal Function and Mechanical Allodynia in the Reserpine-Induced Animal Model of Fibromyalgia.

Dig Dis Sci 2019 Mar 14. Epub 2019 Mar 14.

Faculty of Pharmaceutical Sciences, Aomori University, 2-3-1 Kohbata, Aomori-city, Aomori, 030-0943, Japan.

Background: Fibromyalgia (FM) is a disorder characterized by widespread chronic pain as core symptom and a broad range of comorbidities. Despite the prevalence of gastrointestinal (GI) comorbidities in patients with FM, GI functions have rarely been investigated in animal models of FM.

Aims: The purpose of the present study is to investigate the coexistence of alterations of GI function in the reserpine-induced myalgia (RIM) rat, a validated FM model associated with disruption of monoamine system. Read More

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http://dx.doi.org/10.1007/s10620-019-05577-8DOI Listing
March 2019
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Locostatin Alleviates Liver Fibrosis Induced by Carbon Tetrachloride in Mice.

Dig Dis Sci 2019 Mar 14. Epub 2019 Mar 14.

Department of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, No. 215 Heping West Road, Shijiazhuang, 050000, Hebei, China.

Background And Aims: Liver fibrosis is featured with excessive deposition of extracellular matrix and fibrous connective tissue hyperplasia. The specific inhibitor of Raf-1 kinase inhibitor protein, locostatin, inhibits the migration of hepatic stellate cells. In this study, we investigated the effect of locostatin on liver fibrosis and its underlying mechanism. Read More

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http://link.springer.com/10.1007/s10620-019-05588-5
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http://dx.doi.org/10.1007/s10620-019-05588-5DOI Listing
March 2019
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Utilization of Census Tract-Based Neighborhood Poverty Rates to Predict Non-adherence to Screening Colonoscopy.

Dig Dis Sci 2019 Mar 14. Epub 2019 Mar 14.

Division of Digestive Diseases, Department of Medicine, Rush University Medical Center, 1725 West Harrison Street, Suite 206, Chicago, IL, 60612, USA.

Objectives: Efforts to improve colorectal cancer (CRC) screening rates include recognizing predictors of colonoscopy non-adherence and identifying these high-risk patient populations. Past studies have focused on individual-level factors but few have evaluated the influence of neighborhood-level predictors. We sought to assess the effect of census tract-based neighborhood poverty rates on scheduled screening colonoscopy non-adherence. Read More

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http://dx.doi.org/10.1007/s10620-019-05585-8DOI Listing
March 2019
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Functional Role of Basolateral ClC-2 Channels in the Regulation of Duodenal Anion Secretion in Mice.

Dig Dis Sci 2019 Mar 14. Epub 2019 Mar 14.

Department of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.

Background: Although ClC-2 channels are important in colonic Cl secretion, it is unclear about their roles in small intestinal anion secretion. Therefore, we sought to examine whether ClC-2 channels play important roles in anion secretion, particularly duodenal bicarbonate secretion (DBS).

Methods: Duodenal mucosae from mice were stripped of seromuscular layers and mounted in Ussing chambers. Read More

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http://link.springer.com/10.1007/s10620-019-05578-7
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http://dx.doi.org/10.1007/s10620-019-05578-7DOI Listing
March 2019
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Clinical Impact of Sonographic Transmural Healing After Anti-TNF Antibody Treatment in Patients with Crohn's Disease.

Dig Dis Sci 2019 Mar 14. Epub 2019 Mar 14.

Department of Digestive Medicine, Hospital Universitario Dr. Peset, University of Valencia, Gaspar Aguilar 90, 46017, Valencia, Spain.

Aim: To assess the clinical benefits of transmural healing (TH) shown on intestinal ultrasound (IUS) after treatment with tumor necrosis factor-alpha antibodies (anti-TNF) in patients with Crohn's disease.

Materials And Methods: This prospective study included consecutively 36 patients who underwent IUS in the week prior to start anti-TNF treatment, at 12 weeks, and 1 year after starting treatment. The clinical response to treatment was assessed using the Crohn's disease activity index and C-reactive protein (CRP) values. Read More

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http://dx.doi.org/10.1007/s10620-019-05567-wDOI Listing
March 2019
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What Comes First: Treatment of Viral Hepatitis or Liver Cancer?

Dig Dis Sci 2019 Apr;64(4):1041-1049

Toronto Centre for Liver Disease, Toronto General Hospital, Sandra Rotman Centre for Global Health, University of Toronto, 200 Elizabeth Street, 9EB-240, Toronto, ON, M5G 2C4, Canada.

Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are the most important underlying causes for the development of hepatocellular carcinoma (HCC) worldwide. Determining the optimal approach for management of the viral infection and the HCC depends on the virus and the stage of the cancer. In patients with HCV-associated HCC, there are multiple reasons to first treat the HCC. Read More

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http://dx.doi.org/10.1007/s10620-019-05518-5DOI Listing