1,344,554 results match your criteria Digestive diseases and sciences[Journal]


Process intensification of anaerobic digestion: Influence on mixing and process performance.

Bioresour Technol 2018 Dec 7;274:533-540. Epub 2018 Dec 7.

Chemical & Environmental Engineering, School of Engineering, RMIT University, 124 La Trobe St., Melbourne, VIC 3000, Australia. Electronic address:

The adoption of process intensification to anaerobic digestion can present significant complications for digester mixing and process performance. This work investigated how increasing the solids concentration of the digester sludge influenced the process at various mixing energy inputs. Based on the results, adequate mixing is defined qualitatively as the input of sufficient energy to mobilize the reactor contents without producing significant regions of inhibitory shear force. Read More

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December 2018

Validation of Diagnostic and Performance Characteristics of the Wireless Motility Capsule in Patients With Suspected Gastroparesis.

Clin Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Division of Gastroenterology, Massachusetts General Hospital, Boston, MA. Electronic address:

Background & Aims: It is a challenge to make a diagnosis of gastroparesis. There is good agreement in results from wireless motility capsule (WMC) analysis and gastric emptying scintigraphy (GES), but the diagnostic yield of WMC is unclear and the accuracy of this method has not been validated. We compared the performance characteristics of WMC vs GES in assessing gastric emptying in patients with suspected gastroparesis. Read More

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December 2018

Moina macrocopa as a non-target aquatic organism for assessment of ecotoxicity of silver nanoparticles: Effect of size.

Chemosphere 2018 Dec 7;219:713-723. Epub 2018 Dec 7.

Food Engineering and Technology Department, Institute of Chemical Technology, Mumbai 400019, Maharashtra, India.

The release of nanomaterials in water reservoirs is hazardous. Very few reports are available on the interaction of different sized nanoparticles with aquatic organisms and aquatic environment. In the present study, silver nanoparticles (AgNPs) having an average particle size of 20. Read More

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December 2018

Isolation of the first New Delhi metallo-ß-lactamase-1 (NDM-1) producing, colistin resistant, Klebsiella pneumoniae sequence type ST15, from a digestive carrier in Albania, May 2018.

J Glob Antimicrob Resist 2018 Dec 14. Epub 2018 Dec 14.

Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Objectives: Carbapenemases represent a public health threat as they can spread through horizontal gene transfer and cause outbreaks. NDM-1 is a metallo-ß-lactamase that has spread rapidly in the last decade causing worldwide alarm. We aimed to describe the first isolate of NDM-1 producing and XDR Klebsiella pneumoniae in Albania, its clinical context and genetic characterization. Read More

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December 2018

Early toxicity of a phase II trial of combined salvage radiotherapy and hormone therapy in oligometastatic pelvic node relapses of prostate cancer (OLIGOPELVIS GETUG P07).

Int J Radiat Oncol Biol Phys 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiation Oncology, Institut de Cancérologie de l`Ouest, Boulevard J. Monod, F-44800 Nantes, St-Herblain France; Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), UMR 1232 Inserm - 6299 CNRS, Institut de Recherche en Santé de l`Université de Nantes, 8 quai Moncousu, BP 70721, 44007 Nantes Cedex 1, France. Electronic address:

Purpose: Limited pelvic nodal relapse of prostatic cancer is a paramount challenge for locoregional salvage treatments. Salvage whole pelvis radiotherapy as considered in the BLINDED trial, is an attractive option but with concerns about its toxicity. This article describes early toxicity with the technique. Read More

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December 2018

Comprehensive identification of protein disulfide bonds with pepsin/trypsin digestion, Orbitrap HCD and Spectrum Identification Machine.

J Proteomics 2018 Dec 14. Epub 2018 Dec 14.

Center for Advanced Proteomics Research and Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers University - New Jersey Medical School and Cancer Institute of New Jersey, Newark, NJ 07103, USA. Electronic address:

Disulfide bonds (SS) are post-translational modifications important for the proper folding and stabilization of many cellular proteins with therapeutic uses, including antibodies and other biologics. With budding advances of biologics and biosimilars, there is a mounting need for a robust method for accurate identification of SS. Even though several mass spectrometry methods have emerged for this task, their practical use rests on the broad effectiveness of both sample preparation methods and bioinformatics tools. Read More

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December 2018

Morphology and ultrastructure of the midgut gland ("hepatopancreas") during ontogeny in the common spider crab Maja brachydactyla Balss, 1922 (Brachyura, Majidae).

Arthropod Struct Dev 2018 Dec 14. Epub 2018 Dec 14.

Independent Researcher. Barcelona Spain.

We studied the anatomy and cytology of the midgut gland (MGl) of the common spider crab Maja brachydactyla Balss 1922 at several life stages (zoea, megalopa, first juvenile, and adult) using dissection, histology, electron microscopy, computed tomography, and micro-computed tomography (micro-CT). In newly hatched larvae, 14 blind-end tubules formed the MGl. The length of the tubules increases during the larval development. Read More

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December 2018

Fine structure of the midgut epithelium of Thulinius ruffoi (Tardigrada, Eutardigrada, Parachela) in relation to oogenesis and simplex stage.

Arthropod Struct Dev 2018 Dec 14. Epub 2018 Dec 14.

University of Silesia in Katowice, Department of Animal Histology and Embryology, Bankowa 9, 40-007 Katowice, Poland. Electronic address:

Thulinius ruffoi is a small freshwater tardigrade that lives in both non-polluted and polluted freshwater environments. As a result of tardigradan body miniaturization, the digestive system is reduced and simplified. It consists of a short fore- and hindgut, and the midgut in the shape of a short tube is lined with a simple epithelium. Read More

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December 2018

Recombinant growth hormone therapy for cystic fibrosis in children and young adults.

Cochrane Database Syst Rev 2018 Dec 17;12:CD008901. Epub 2018 Dec 17.

Division of Molecular Genetics, Department of Pediatrics, Columbia University Medical Center, 630 West 168th St., New York, NY, USA, 10032.

Background: Cystic fibrosis (CF) is an inherited condition causing disease most noticeably in the lungs, digestive tract and pancreas. People with CF often have malnutrition and growth delay. Adequate nutritional supplementation does not improve growth optimally and hence an anabolic agent, recombinant human growth hormone (rhGH), has been proposed as a potential intervention. Read More

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December 2018

Effects of supplemental vitamin D and calcium on markers of proliferation, differentiation, and apoptosis in the normal colorectal mucosa of colorectal adenoma patients.

PLoS One 2018 17;13(12):e0208762. Epub 2018 Dec 17.

Department of Epidemiology, Emory University, Atlanta, Georgia, United States of America.

To clarify the roles of vitamin D and calcium as potential chemopreventive agents against colorectal cancer in humans, and to develop "treatable", pre-neoplastic, phenotypic biomarkers of risk for colorectal neoplasms, we estimated the effects of supplemental vitamin D3 (1,000 IU/day [25 μg/day]) and calcium (1,200 mg/day), alone and in combination, on biomarkers of proliferation (mib-1), differentiation (p21), and apoptosis (bax [apoptosis-promoting] and bcl-2 [apoptosis-inhibiting]), in the normal-appearing rectal mucosa in a subsample of participants (n = 104) in a larger randomized, double-blind, placebo-controlled clinical trial among colorectal adenoma patients. The biomarkers were measured in rectal biopsies at baseline and after one year of follow up, using automated immunohistochemistry and quantitative image analysis. In the vitamin D plus calcium group relative to control, in the crypt differentiation zone (upper 40% of crypts), mib-1 expression decreased 24% (P = 0. Read More

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December 2018

Identification of long intergenic non-coding RNAs (lincRNAs) deregulated in gastrointestinal stromal tumors (GISTs).

PLoS One 2018 17;13(12):e0209342. Epub 2018 Dec 17.

Institute for Digestive Research, Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Long intergenic non-coding RNAs (lincRNAs) are >200 nucleotides long non-coding RNAs, which have been shown to be implicated in carcinogenic processes by interacting with cancer associated genes or other non-coding RNAs. However, their role in development of rare gastrointestinal stromal tumors (GISTs) is barely investigated. Therefore, the aim of this study was to define lincRNAs deregulated in GIST and find new GIST-lincRNA associations. Read More

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December 2018
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A novel preservation solution containing a JNK inhibitory peptide efficiently improves islet yield for porcine islet isolation.

Transplantation 2018 Dec 13. Epub 2018 Dec 13.

Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Background: For islet transplantation, pancreas preservation in UW solution is associated with disadvantages such as collagenase inhibition, resulting in poor islet yield and islets with poor viability. In this study, we evaluated a novel preservation solution, the extracellular-type c-Jun N-terminal kinase (JNK) inhibitor-containing (EJ) solution.

Methods: EJ solution has high sodium-low potassium composition with low viscosity compared to UW solution. Read More

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December 2018

The pharmacokinetics, pharmacodynamics, and mucosal responses to maraviroc-containing PrEP Regimens in Men who have Sex with Men.

AIDS 2018 Dec 13. Epub 2018 Dec 13.

Division of Infectious Diseases, Weill Cornell Medicine, New York, New York.

Objective: HIV Prevention Trials Network 069/AIDS Clinical Trials Group A5305 was a study of 48-week oral pre-exposure prophylaxis (PrEP) regimens in MSM and transgender women. A rectal substudy was included to evaluate drug concentrations in rectal compartment vs. blood, gut-associated lymphoid tissue (GALT) responses to four antiretroviral PrEP regimens [maraviroc (MVC), MVC + emtricitabine (FTC), MVC + tenofovir (TFV) disoproxil fumarate, and TFV disoproxil fumarate + FTC], and to determine whether ARV exposure was associated with ex-vivo suppression of HIV infection in colorectal explants. Read More

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December 2018

Innovative operational strategies for biogas plant including temperature and stirring management.

Waste Manag Res 2018 Dec 17:734242X18816800. Epub 2018 Dec 17.

TUHH - Hamburg University of Technology, Institute of Environmental Technology and Energy Economics, Waste Resources Management, Hamburg, Germany.

Finding the optimum operational conditions (mainly temperature and stirring) inside the fermenters is crucial in the field of anaerobic digestion. This study was conducted to contribute to the research area of anaerobic digestion process optimization and is an example for other biogas plants to improve efficiency. The research aimed at finding the optimum operational conditions in a large-scale biogas plant located in Lower Saxony, Germany, which started operation in 2011. Read More

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December 2018

Carrier-assisted single-tube processing approach for targeted proteomics analysis of low numbers of mammalian cells.

Anal Chem 2018 Dec 17. Epub 2018 Dec 17.

Heterogeneity in composition is inherent in all cell populations, even those containing a single cell type. Single-cell proteomics characterization of cell heterogeneity is currently achieved by antibody-based technologies, which are limited by the availability of high-quality antibodies. Herein we report a simple, easily implemented, mass spectrometry-based targeted proteomics approach, termed cLC-SRM (carrier-assisted liquid chromatography coupled to selected reaction monitoring), for reliable multiplexed quantification of proteins in low numbers of mammalian cells. Read More

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December 2018

Embryogenesis and early larval development in wild-caught Levantine scraper, Capoeta damascina (Valenciennes, 1842).

J Morphol 2019 Jan;280(1):133-148

School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, AL, USA.

Levantine scraper, Capoeta damascina is a candidate species for future stock assessments, conservation studies, and hatchery efforts. Herein, we documented embryonic and early larval development, from egg activation to the exogenous feeding period, using morphological and histological landmarks. Embryos were obtained by in vitro fertilization from hormonally induced wild-caught broodstock, and subsequent development was monitored at temperatures coinciding with native conditions. Read More

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January 2019

Circ_0009910 regulates growth and metastasis and is associated with poor prognosis in gastric cancer.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8248-8256

Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Cancer Invasion and Metastasis Research and National Clinical Research Center for Digestive Diseases, Xi-Cheng District, Beijing, P.R. China.

Objective: Circular RNAs (circRNAs) have recently shown capabilities as gene regulators in mammals. In this study, we aimed to evaluate the effects and mechanism of circ_0009910 in gastric cancer (GC).

Patients And Methods: Circ_0009910 expression was quantified by Real-time PCR in human GC cell lines and tissues. Read More

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December 2018

Twist1/2 activates MMP2 expression via binding to its promoter in colorectal cancer.

Authors:
K Lu J-L Dong W-J Fan

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8210-8219

Department of Digestive Diseases, Zhoukou Central hospital, Zhoukou, Henan, China.

Objective: This study aimed to characterize the effect of Twist2 on epithelial-to-mesenchymal transition (EMT) and the invasive potential of colorectal cancer (CRC) cells and to explore the mechanisms underlying the regulative effect of Twist1 and Twist2 on matrix metalloproteinase 2 (MMP2) expression in CRC.

Patients And Methods: Data mining was performed in colorectal cancer cohort (COADREAD) in the Cancer Genome Atlas (TCGA-COADREAD). CRC LoVo and HCT116 cells were used as in vitro cell models. Read More

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December 2018

Properties of oils from plantain pseudostem biotransformed using crude local enzyme sources: a comparison of poultry feed oil.

Recent Pat Food Nutr Agric 2018 Dec 17. Epub 2018 Dec 17.

Department of Biochemistry, University of Port Harcourt, Choba, Rivers State. Nigeria.

Objectives: Plantain pseudostem (PPS) wastes were biotransformed by applying simultaneous saccharification and fermentation (SSF) using excised snail digestive juice and yeast slurry, and their oil properties compared with oils from commercially sold poultry feeds (PF). Patents suggesting inclusion of certain additives (US20090226558A1), spices (US5741508A), cysteamine (US4711897A), and dextrin (US6326051B1) in animal diets are regarded as expensive, thus, requiring cheaper and readily available sources of growth.

Methods: The analysis of their free radical scavenging potentials was carried by spectrophotometry, while fatty acids, volatile fatty acids, essentials oils, and phytosterols were determined by chromatography. Read More

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December 2018

Inhibition of α-amylase activity by Zn2+: insights from spectroscopy and molecular dynamics simulations.

Med Chem 2018 Dec 16. Epub 2018 Dec 16.

College of Life Science and Technology, Guangxi University, Nanning, Guangxi, 530004 . China.

Background: Inhibition of α-amylase activity is an important strategy in the treatment of diabetes mellitus. An important treatment for diabetes mellitus is to reduce the digestion of carbohydrates and blood glucose concentrations. Inhibiting the activity of carbohydrate-degrading enzymes such as α-amylase and glucosidase significantly decreases the blood glucose level. Read More

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December 2018

Preventing secondary exposure to women from men applying a novel nestorone/testosterone contraceptive gel.

Andrology 2018 Dec 16. Epub 2018 Dec 16.

Department of Medicine, Division of Endocrinology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.

Background: Testosterone (T)/Nestorone (NES) combination gel is a potential transdermal male contraceptive that suppresses gonadotropins and spermatogenesis. Transfer of transdermal T from men to women can be prevented by washing or covering application sites with clothing.

Objectives: We hypothesized that showering or wearing a shirt over gel application sites would prevent secondary exposure of T and NES to a woman after close skin contact. Read More

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December 2018
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Individual diet specialisation in sparrows is driven by phenotypic plasticity in traits related to trade-offs in animal performance.

Ecol Lett 2019 Jan;22(1):128-137

Departamento de Ciencias Ecológicas, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile.

Individual diet specialisation (IS) is frequent in many animal taxa and affects population and community dynamics. The niche variation hypothesis (NVH) predicts that broader population niches should exhibit greater IS than populations with narrower niches, and most studies that examine the ecological factors driving IS focus on intraspecific competition. We show that phenotypic plasticity of traits associated with functional trade-offs is an important, but unrecognised mechanism that promotes and maintains IS. Read More

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January 2019

Association study between two polymorphisms of tumor necrosis factor ligand superfamily member 15 (TNFSF15) gene and ulcerative colitis in south-west of Iran.

J Cell Biochem 2018 Dec 16. Epub 2018 Dec 16.

Research Center for Infectious Diseases of Digestive System, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

BACKGROUND AND AIMS: Ulcerative colitis (UC) is the most prevalent clinical manifestation of the inflammatory bowel disease (IBD). Several candidate genes have been suggested to be involved in the genetic susceptibility or resistance in the development of UC. Among them, tumor necrosis factor ligand superfamily member 15 (TNFSF15) have been reported in association with IBD in several studies. Read More

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December 2018

Prohibitin 1 Acts As a Negative Regulator of Wingless/Integrated-Beta-Catenin Signaling in Murine Liver and Human Liver Cancer Cells.

Hepatol Commun 2018 Dec 27;2(12):1583-1600. Epub 2018 Sep 27.

Division of Digestive and Liver Diseases, Department of Medicine Cedars Sinai Medical Center Los Angeles CA.

Prohibitin1 () is a mitochondrial chaperone with diverse functions that include cell proliferation, apoptosis, and mitochondrial homoeostasis. Liver-specific knockout (KO) mice develop spontaneous injury and hepatocellular carcinoma (HCC). Our previous work demonstrated that PHB1 negatively regulates the H19-insulin-like growth factor 2 (IGF2)-H19-IGF2 axis signaling pathway and E-box activity in hepatocytes and HCC cells. Read More

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December 2018
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Acute-on-Chronic Liver Failure: An Old Entity in Search of Clarity.

Hepatol Commun 2018 Dec 10;2(12):1421-1424. Epub 2018 Dec 10.

Section of Digestive Diseases Yale University School of Medicine New Haven CT.

It is a commentary intended to outline and try to clarify some of the issues that have led to confusion in the field regarding acute-on-chronic liver failure. Read More

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December 2018

Imaging-Guided Nanoplatform for Tumor Targeting Delivery and Combined Chemo-, Gene- and Photothermal Therapy.

Theranostics 2018 10;8(20):5662-5675. Epub 2018 Nov 10.

Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, P. R. China.

Currently, a large number of anti-tumor drug delivery systems have been widely used in cancer therapy. However, due to the molecular complexity and multidrug resistance of tumors, monotherapies remain suboptimal. Thus, this study aimed to develop a multifunctional theranostic nanoplatform for effective cancer therapy. Read More

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November 2018

Expression of a Recombinant Xylanase by and Its Effects on Ruminal Fermentation and Microbial Community in Incubation of Agricultural Straws.

Front Microbiol 2018 30;9:2944. Epub 2018 Nov 30.

Jiangxi Province Key Laboratory of Animal Nutrition/Engineering Research Center of Feed Development, Jiangxi Agricultural University, Nanchang, China.

Agricultural straws, such as rice straw, wheat straw, and corn straw, are produced abundantly every year but not utilized efficiently in China. An experiment was conducted to determine the effects of recombinant xylanase on ruminal fermentation and microbial community structure in incubation of these straws. The recombinant xylanase from (rLeXyn11A) was produced in . Read More

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November 2018

Ammonia Inhibition of Anaerobic Volatile Fatty Acid Degrading Microbial Communities.

Front Microbiol 2018 30;9:2921. Epub 2018 Nov 30.

Department of Environmental Microbiology, UFZ-Helmholtz Center for Environmental Research, Leipzig, Germany.

Ammonia inhibition is an important reason for reactor failures and economic losses in anaerobic digestion. Its impact on acetic acid degradation is well-studied, while its effect on propionic and butyric acid degradation has received little attention and is consequently not considered in the Anaerobic Digestion Model No. 1 (ADM1). Read More

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November 2018

Comparative Microbiome Signatures and Short-Chain Fatty Acids in Mouse, Rat, Non-human Primate, and Human Feces.

Front Microbiol 2018 30;9:2897. Epub 2018 Nov 30.

Department of Internal Medicine-Molecular Medicine, Wake Forest School of Medicine, Center for Diabetes, Obesity and Metabolism, Winston-Salem, NC, United States.

Gut microbiome plays a fundamental role in several aspects of host health and diseases. There has been an exponential surge in the use of animal models that can mimic different phenotypes of the human intestinal ecosystem. However, data on host species-specific signatures of gut microbiome and its metabolites like short-chain fatty acids (SCFAs; i. Read More

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November 2018

Association Between Type I and II Diabetes With Gallbladder Stone Disease.

Front Endocrinol (Lausanne) 2018 29;9:720. Epub 2018 Nov 29.

Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.

To assess the association of type 1 diabetes (T1DM) and type 2 diabetes (T2DM) with the subsequent development of gallbladder stone disease (GSD). Cohort Study. We identified two study cohort groups to evaluate the association of T1DM and T2DM with the development of GSD. Read More

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November 2018

Pathophysiology of NSAID-Associated Intestinal Lesions in the Rat: Luminal Bacteria and Mucosal Inflammation as Targets for Prevention.

Front Pharmacol 2018 29;9:1340. Epub 2018 Nov 29.

Clinical Pharmacology & Digestive Pathophysiology Unit, Department of Clinical & Experimental Medicine, University of Parma, Parma, Italy.

Non-steroidal anti-inflammatory drugs (NSAIDs) can damage the small intestine, mainly through an involvement of enteric bacteria. This study examined the pathophysiology of NSAID-associated intestinal lesions in a rat model of diclofenac-enteropathy and evaluated the effect of rifaximin on small bowel damage. Enteropathy was induced in 40-week old male rats by intragastric diclofenac (4 mg/kg BID, 14 days). Read More

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November 2018

Activation of polymeric nanoparticle intracellular targeting overcomes chemodrug resistance in human primary patient breast cancer cells.

Int J Nanomedicine 2018 29;13:8153-8164. Epub 2018 Nov 29.

The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY 12144, USA,

Background: Successfully overcoming obstacles due to anticancer drugs' toxicity and achieving effective treatment using unique nanotechnology is challenging. The complex nature of breast tumors is mainly due to chemoresistance. Successful docetaxel (DTX) delivery by nanoparticles (NPs) through inhibition of multidrug resistance (MDR) can be a bridge to enhance intracellular dose and achieve higher cytotoxicity for cancer cells. Read More

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November 2018

Toward the universal scoring system in treatment for patients with hepatocellular carcinoma.

J Hepatol 2018 Dec 13. Epub 2018 Dec 13.

Cleveland Clinic Lerner College of Medicine and Department of General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

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December 2018

Intrinsic Dynamics of a Human Gene Reveal the Basis of Expression Heterogeneity.

Cell 2018 Dec 10. Epub 2018 Dec 10.

Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD, USA. Electronic address:

Transcriptional regulation in metazoans occurs through long-range genomic contacts between enhancers and promoters, and most genes are transcribed in episodic "bursts" of RNA synthesis. To understand the relationship between these two phenomena and the dynamic regulation of genes in response to upstream signals, we describe the use of live-cell RNA imaging coupled with Hi-C measurements and dissect the endogenous regulation of the estrogen-responsive TFF1 gene. Although TFF1 is highly induced, we observe short active periods and variable inactive periods ranging from minutes to days. Read More

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December 2018

[Clear cell sarcoma or gastrointestinal neuroectodermal tumor (GNET) of the tongue? Case report and review of the literature of an extremely rare tumor localization].

Ann Pathol 2018 Dec 13. Epub 2018 Dec 13.

Service d'anatomie pathologique, hôpital André-Mignot, centre hospitalier de Versailles, 177, rue de Versailles, 78150 Le Chesnay, France. Electronic address:

Clear cells sarcomas (CCS) are exceptionally rare in the tongue, with, to our knowledge, only three previous reports in anglo-saxon literature. Through our case, we will discuss the differential diagnosis of clear cells tumors of the tongue and bring this tumour closer to the newly described entity of the gastrointestinal tract named "clear cells sarcoma-like gastrointestinal (SCCLGI)", recently renamed "gastrointestinal neuroectodermal tumour (GNET)". SCCLGI/GNET share morphological and molecular characteristics with SCC but had until then been observed only in the digestive tract. Read More

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December 2018

The diagnostic role of triple endoscopy in pediatric patients with chronic cough.

Int J Pediatr Otorhinolaryngol 2019 Jan 13;116:58-61. Epub 2018 Oct 13.

Pediatric Department Massachusetts Eye and Ear Infirmary, Airway and Swallowing Center Massachusetts Eye and Ear Infirmary, United States.

Objective/hypothesis: Multi-disciplinary aero-digestive centers provide high quality health care through improved outcomes and treatment costs over separate sub specialty clinics. These outcomes are often the result of a common investigative tool known as triple endoscopy: a rigid bronchoscopy performed by an otolaryngologist, flexible bronchoscopy and lavage obtained by a pulmonologist, and an endoscopy with guided biopsies performed by a gastroenterologist. Combining such procedures into one 'triple endoscopy' allows for diagnoses which otherwise might have been missed with just one procedure. Read More

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January 2019

[Overexpression of miR-107 promotes the proliferation and tumorigenic ability of HT29 cells].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2018 Oct;34(10):908-913

Xijing Hospital of Digestive Diseases, Air Force Military Medical University, Xi'an 710032, China. *Corresponding author, E-mail:

Objective To investigate the effect of miR-107 on the proliferation of colorectal cancer cells. Methods The expression of miR-107 was detected in colorectal cancer tissues and colorectal cancer cell lines by real-time quantitative PCR (qRT-PCR). miR-107 expression was up-regulated and down-regulated by the transfection of miR-107 mimic and miR-107 inhibitor in HT29 cells, respectively. Read More

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October 2018

[Preparation of in vitro transcribed mouse MUC1 mRNA and its expression in NIH/3T3 cells].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2018 Oct;34(10):896-901

Key Laboratory of Biology and Medical Engineering, Immune Cells and Antibody Engineering Research Center of Guizhou Province, Engineering Research Center of Medical Biotechnology, State Key Laboratory of Functions and Applications of Medicinal Plants, School of Biology and Engineering, Guizhou Medical University, Guiyang 550025, China. *Corresponding author, E-mail:

Objective To obtain in vitro transcription of mouse mucin 1(MUC1) mRNA and express it in NIH/3T3 cells. Methods The MUC1 gene was amplified from mouse 4T1 cells by reverse transcription PCR (RT-PCR), and then inserted into the eukaryotic expression vector pcDNA3.1(+) to construct the recombinant vector pcDNA3. Read More

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October 2018

Wheat gluten intake increases the severity of experimental colitis and bacterial translocation by weakening of the proteins of the junctional complex.

Br J Nutr 2018 Dec 17:1-13. Epub 2018 Dec 17.

1Departamento de Bioquímica e Imunologia,Universidade Federal de Minas Gerais,Belo Horizonte, MG,31270-901,Brazil.

Gluten is only partially digested by intestinal enzymes and can generate peptides that can alter intestinal permeability, facilitating bacterial translocation, thus affecting the immune system. Few studies addressed the role of diet with gluten in the development of colitis. Therefore, we investigate the effects of wheat gluten-containing diet on the evolution of sodium dextran sulphate (DSS)-induced colitis. Read More

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December 2018

Effects of substituting kraft pulp with corn silage on dry matter intake, ruminal mat formation, rumen fermentation, and rumination activity in non-lactating cows.

Anim Sci J 2018 Dec 16. Epub 2018 Dec 16.

College of Agriculture, Food and Environment Sciences, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.

The present study examined the effects of substituting kraft pulp (KP) with corn silage (CS) on dry matter intake (DMI), ruminal mat and rumen fermentation characteristics, and rumination. Four non-lactating, rumen-cannulated Holstein cows were fed a CS diet comprising 36% grass silage (GS) and 64% CS or a KP diet comprising 36% GS, 57% KP, and 7% soybean meal. DMI was significantly lower in cows fed the KP diet than in those fed the CS diet (p < 0. Read More

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December 2018
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The survival of pathogenic bacteria and plant growth promoting bacteria during mesophilic anaerobic digestion in full-scale biogas plants.

Anim Sci J 2018 Dec 16. Epub 2018 Dec 16.

Graduate School of Animal and Food Hygiene, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan.

The introduction of biogas plants is a promising way to recycle organic wastes with renewable energy production and reducing greenhouse gas. Application of anaerobic digestate as a fertilizer reduces the consumption of chemical fertilizers. In this study, the survival of pathogenic bacteria and plant growth promoting bacteria (PGPB) in two full-scale biogas plants operated at mesophilic condition were investigated. Read More

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December 2018
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Iterative cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: A multi-institutional experience.

J Surg Oncol 2018 Dec 16. Epub 2018 Dec 16.

St. George Hospital & University of New South Wales, Department of Surgery, Sydney, NSW, Australia.

Background And Objectives: The aims of this multi-institutional study were to assess the feasibility of iterative cytoreductive surgery (iCRS)/hyperthermic intraperitoneal chemotherapy, iCRS in colorectal peritoneal carcinomatosis (CRPC), evaluate survival, recurrence, morbidity and mortality outcomes, and identify prognostic factors for overall survival.

Methods: Patients with CRPC that underwent an iCRS, with or without intraperitoneal chemotherapy, from June 1993 to July 2016 at 13 institutions were retrospectively analyzed from prospectively maintained databases.

Results: The study comprised of 231 patients, including 126 females (54. Read More

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December 2018

Quorum sensing between Gram-negative bacteria responsible for methane production in a complex waste sewage sludge consortium.

Appl Microbiol Biotechnol 2018 Dec 15. Epub 2018 Dec 15.

Department of Biological Functions Engineering, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu, Kitakyushu, 808-0196, Japan.

Quorum sensing (QS) plays a key role in activating bacterial functions through small molecules called autoinducers. In this study, the QS of Gram-negative bacteria in waste sewage sludge (WSS) was downregulated by adding the quorum quenching enzyme, AiiM lactonase, which cleaved the acyl-homoserine lactone (AHL) autoinducer signals from Gram-negative bacteria, and subsequently methane production was inhibited by over 400%. The pH was lowered after 2 days in the anaerobic fermentation whereas protease activity at the hydrolysis step was almost the same with or without AiiM. Read More

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December 2018

Minimally Invasive Function-Preserving Gastrectomy with Sentinel Node Biopsy for Early Gastric Cancer.

Digestion 2018 Dec 14;99(1):14-20. Epub 2018 Dec 14.

Department of Surgery, Keio University School of Medicine, Tokyo, Japan.

Background: Recently, minimally invasive approaches such as endoscopic treatment or laparoscopic gastrectomy for early gastric cancer have made rapid progress. However, the extent of gastrectomy and lymphadenectomy in laparoscopic surgery is radical, similar to that of open gastrectomy for patients with early gastric cancer diagnosed as not indicated for endoscopic treatment. Since it is well known that lymph node metastasis is an important prognostic factor, the standard procedure of gastrectomy with radical lymph node dissection has been performed for the purpose of curative resection. Read More

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December 2018
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Irritable Bowel Syndrome-Like Symptoms in Ulcerative Colitis Patients in Clinical Remission: Association with Residual Colonic Inflammation.

Digestion 2018 Dec 14;99(1):46-51. Epub 2018 Dec 14.

Department of Internal Medicine II, Shimane University Faculty of Medicine, Izumo, Japan.

Ulcerative colitis (UC) patients in clinical remission often experience irritable bowel syndrome (IBS)-like symptoms. The prevalence rate of UC patients meeting the definition of IBS, such as shown by the Rome criteria, is significantly higher in those without ongoing clinical activity as compared to healthy controls. Several studies have investigated residual low-grade inflammation found in colonic mucosa of quiescent UC patients and its association with development of IBS-like symptoms. Read More

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December 2018

Recurrence Patterns and Outcomes of Salvage Surgery in Cases of Non-Curative Endoscopic Submucosal Dissection without Additional Radical Surgery for Early Gastric Cancer.

Digestion 2018 Dec 14;99(1):52-58. Epub 2018 Dec 14.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background/aims: The outcomes of salvage surgery for recurrence after non-curative endoscopic submucosal dissection (ESD) without additional radical surgery for early gastric cancer (EGC) remain unclear. We determined the recurrence patterns and outcomes of salvage surgery in such cases using data from a multicenter, retrospective study.

Methods: Of 15,785 patients who underwent ESD for EGC at 19 participating institutions between January 2000 and August 2011, 1,969 failed to meet the current curative criteria after ESD. Read More

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December 2018
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Current Status and Challenges of Endoscopic Treatments for Duodenal Tumors.

Digestion 2018 Dec 14;99(1):21-26. Epub 2018 Dec 14.

Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Tokyo,

Background: Superficial tumors of the duodenum, other than ampullary tumors, have been traditionally considered rare. However, reports of this kind of tumor have increased in recent times, and the demand for minimally invasive treatments have also increasing.

Summary: Adenomas and intramucosal carcinomas are target lesions for treatment. Read More

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December 2018

Low Skeletal Muscle Mass before Salvage-Line Chemotherapy Is a Poor Prognostic Factor in Patients with Refractory Metastatic Colorectal Cancer.

Digestion 2018 Dec 14;99(1):79-85. Epub 2018 Dec 14.

Background: Regorafenib and TAS-102 are standard salvage-line treatment options for patients with chemorefractory metastatic colorectal cancer (mCRC). We aimed to evaluate the prognostic significance of skeletal muscle mass in mCRC patients receiving these salvage-line therapies.

Methods: We conducted a retrospective analysis of 52 patients with mCRC who received regorafenib or TAS-102 as salvage-line treatment. Read More

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December 2018

The Incidence and Risk Factors of Venous Thromboembolism in Patients with Inflammatory Bowel Disease: A Prospective Multicenter Cohort Study.

Digestion 2018 Dec 14:1-9. Epub 2018 Dec 14.

Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.

Background: Venous thromboembolism (VTE) has been shown to be more frequent in inflammatory bowel disease (IBD) than in the general population in Western studies. However, the actual state of VTE in Asian IBD remains poorly understood.

Aims: To reveal the incidence of VTE in IBD patients in Japan. Read More

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December 2018

Gastric Cancer with Submucosal Invasion after Successful Helicobacter pylori Eradication: A Propensity Score-Matched Analysis of Patients with Annual Patient Endoscopic Survey.

Digestion 2018 Dec 14;99(1):59-65. Epub 2018 Dec 14.

Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan.

Background And Aim: The incidence of gastric cancer occurring after successful Helicobacter pylori eradication has been increasing. We aimed to clarify the influence of eradication therapy on the ability to diagnose early gastric cancer after successful H. pylori eradication in patients who underwent annual endoscopic screening. Read More

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December 2018
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