15,255 results match your criteria Digestive diseases and sciences[Journal]


Balancing the Checkpoint: Managing Colitis Associated with Dual Checkpoint Inhibitors and High-Dose Aspirin.

Dig Dis Sci 2019 Feb 18. Epub 2019 Feb 18.

Department of Medicine, University of California, San Francisco, 513 Parnassus Ave, S-357, San Francisco, CA, 94143-0451, USA.

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http://dx.doi.org/10.1007/s10620-019-05534-5DOI Listing
February 2019

Endocut Versus Conventional Blended Electrosurgical Current for Endoscopic Biliary Sphincterotomy: A Meta-Analysis of Complications.

Dig Dis Sci 2019 Feb 18. Epub 2019 Feb 18.

Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Yangpu District, Shanghai, 200433, China.

Background And Aims: Endoscopic biliary sphincterotomy (EST) is commonly performed during therapeutic endoscopic retrograde cholangiopancreatography (ERCP), but is an independent risk factor for post-ERCP pancreatitis, bleeding and duodenal perforation. These are partly ascribed to the electrosurgical current mode used for EST, and currently the optimal current model for EST remains controversial. In this study, we aimed to compare the rate of complications undergoing EST using the Endocut versus the blended current. Read More

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http://dx.doi.org/10.1007/s10620-019-05513-wDOI Listing
February 2019

Correction to: Fecal Microbiota Transplantation Capsules with Targeted Colonic Versus Gastric Delivery in Recurrent Clostridium difficile Infection: A Comparative Cohort Analysis of High and Low Dose.

Dig Dis Sci 2019 Feb 18. Epub 2019 Feb 18.

Finch Therapeutics, Somerville, MA, USA.

The original version of the article unfortunately contained an error in article title. The corrected title is 'Fecal Microbiota Transplantation Capsules with Targeted Colonic Versus Gastric Delivery in Recurrent Clostridium difficile Infection: A Comparative Cohort Analysis of High and Low Dose'. Read More

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http://dx.doi.org/10.1007/s10620-019-05527-4DOI Listing
February 2019

Impact of Peppermint Therapy on Dysphagia and Non-cardiac Chest Pain: A Pilot Study.

Dig Dis Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, Division of Gastroenterology and Hepatology, Medical University of South Carolina, 30 Courtenay Drive, Suite 249, MSC 702, Charleston, SC, 29425-2900, USA.

Background: Due to its smooth muscle relaxing properties, peppermint oil (PO) may relieve dysphagia and chest pain due to esophageal motility disorders.

Aim: To explore the impact of PO on dysphagia and/or chest pain in patients referred for motility testing.

Methods: Patients initiated on PO for dysphagia and/or chest pain from 2013 to 2016 were identified. Read More

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http://link.springer.com/10.1007/s10620-019-05523-8
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http://dx.doi.org/10.1007/s10620-019-05523-8DOI Listing
February 2019
6 Reads

Update on the Diagnosis and Management of Gastric Intestinal Metaplasia in the USA.

Dig Dis Sci 2019 Feb 15. Epub 2019 Feb 15.

Division of Gastroenterology and Hepatology, University of Virginia, P.O. Box 800708, Charlottesville, VA, 22908, USA.

Gastric intestinal metaplasia (GIM) is a premalignant condition that can lead to intestinal-type gastric adenocarcinoma. It is characterized by a change in the gastric mucosa to a small-intestinal phenotype. Infection with Helicobacter pylori is the most common factor associated with GIM. Read More

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http://dx.doi.org/10.1007/s10620-019-05526-5DOI Listing
February 2019
1 Read

Concise Commentary: Treatment of Recurrent C. difficile Infection: A New Take on the Fecal-Oral Route.

Dig Dis Sci 2019 Feb 14. Epub 2019 Feb 14.

Gastroenterology Center of Connecticut, Yale University School of Medicine, New Haven, CT, USA.

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http://dx.doi.org/10.1007/s10620-019-05498-6DOI Listing
February 2019

Effects of Tec Tyrosine Kinase Inhibition on the Inflammatory Response of Severe Acute Pancreatitis-Associated Acute Lung Injury in Mice.

Dig Dis Sci 2019 Feb 14. Epub 2019 Feb 14.

Department of Gastroenterology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan, 250012, Shandong Province, China.

Background: The Tec kinase family is involved in acute and chronic inflammatory diseases, but its relationship with severe acute pancreatitis (SAP) remains unclear.

Aims: To investigate whether Tec tyrosine kinase can be used as a target for severe acute pancreatitis-associated acute lung injury (PALI).

Methods: A total of 90 mice were randomly assigned into four groups: SAP (n = 15), control (n = 15), SAP + α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13) (pretreated with Tec kinase inhibitor LFM-A13, n = 15), and SAP + Tec siRNA (pretreated with PBS/negative control siRNA/Tec siRNA, n = 45). Read More

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http://dx.doi.org/10.1007/s10620-019-05524-7DOI Listing
February 2019
1 Read

Evidence of Significant Ceftriaxone and Quinolone Resistance in Cirrhotics with Spontaneous Bacterial Peritonitis.

Dig Dis Sci 2019 Feb 14. Epub 2019 Feb 14.

Liver Center, Beth Israel Deaconess Medical Center, 110 Francis St, LMOB 8E, Boston, MA, 02215, USA.

Objectives: There are few studies addressing the impact of cephalosporin and quinolone resistance on hospital length of stay and mortality in spontaneous bacterial peritonitis (SBP). We aim to describe the shifting epidemiology of SBP at our institution and its impact on clinical outcomes.

Methods: We performed a single-center retrospective cohort study of all cases of SBP from 2005 to 2015 at a transplant center. Read More

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http://dx.doi.org/10.1007/s10620-019-05519-4DOI Listing
February 2019

Risk Behaviors Associated with Alcohol Consumption Predict Future Severe Liver Disease.

Dig Dis Sci 2019 Feb 14. Epub 2019 Feb 14.

Stress Research Institute, Stockholm University, Stockholm, Sweden.

Background: Excess consumption of alcohol can lead to cirrhosis, but it is unclear whether the type of alcohol and pattern of consumption affects this risk.

Aims: We aimed to investigate whether type and pattern of alcohol consumption early in life could predict development of severe liver disease.

Methods: We examined 43,242 adolescent men conscribed to military service in Sweden in 1970. Read More

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http://dx.doi.org/10.1007/s10620-019-05509-6DOI Listing
February 2019

New Face of Hepatitis C.

Dig Dis Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

Chronic hepatitis C viral (HCV) infection continues to carry a high burden of disease despite recent and emerging advancements in treatment. The persistently high prevalence of HCV is attributed to the rising opioid epidemic, with a history of injection drug use as the primary risk factor for infection. As a result, the epidemiology of HCV-infected individuals is changing. Read More

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http://link.springer.com/10.1007/s10620-019-05511-y
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http://dx.doi.org/10.1007/s10620-019-05511-yDOI Listing
February 2019
1 Read

Personalized Inflammatory Bowel Disease Care Reduced Hospitalizations.

Dig Dis Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Medicine, Central Arkansas Veterans Healthcare System, Little Rock, AR, USA.

Background And Aims: IBD patients with inadequately treated disease often relapse and require hospitalizations for further management. The purpose of this practice review was to determine whether personalized IBD care improved patient outcomes as measured by IBD-related hospitalizations.

Methods: A dedicated IBD clinic was created for personalized patient care in a tertiary veterans health care center in 2014. Read More

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http://dx.doi.org/10.1007/s10620-019-05485-xDOI Listing
February 2019
2 Reads

Receipt of Preventive Care Services Among US Adults with Inflammatory Bowel Disease, 2015-2016.

Dig Dis Sci 2019 Feb 12. Epub 2019 Feb 12.

Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Mailstop F-78, 4770 Buford Highway NE, Atlanta, GA, 30341, USA.

Background: Previous reports suggest that adults with inflammatory bowel disease (IBD) receive suboptimal preventive care.

Aims: The population-based study compared the receipt of these services by US adults with and without IBD.

Methods: Adults aged ≥ 18 years with IBD (1. Read More

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http://link.springer.com/10.1007/s10620-019-05494-w
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http://dx.doi.org/10.1007/s10620-019-05494-wDOI Listing
February 2019
2 Reads

Transpapillary Biliary Cannulation is Difficult in Cases with Large Oral Protrusion of the Duodenal Papilla.

Dig Dis Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Gastroenterology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0375, Japan.

Background: Biliary cannulation failure is a major problem during endoscopic retrograde cholangiopancreatography. It remains unclear how duodenal papilla morphology affects biliary cannulation. Therefore, we proposed a new classification system for the duodenal papilla based on oral protrusion pattern (ratio of the length of the oral protrusion to the transverse diameter of the papilla) and papilla pattern. Read More

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http://dx.doi.org/10.1007/s10620-019-05510-zDOI Listing
February 2019

Acknowledgment of 2018 Reviewers.

Authors:

Dig Dis Sci 2019 Feb 12. Epub 2019 Feb 12.

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http://dx.doi.org/10.1007/s10620-019-05512-xDOI Listing
February 2019

Predictive Value of Procalcitonin in Acute Severe Ulcerative Colitis: Not Quite PerfeCT?

Dig Dis Sci 2019 Feb 7. Epub 2019 Feb 7.

Digestive Disease Center, CHA University Bundang Medical Center, 59 Yatap-ro, Bundang-gu, Seongnam, Korea.

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http://dx.doi.org/10.1007/s10620-019-05481-1DOI Listing
February 2019

Competitive Endogenous RNA (ceRNA) Regulation Network of lncRNA-miRNA-mRNA in Colorectal Carcinogenesis.

Dig Dis Sci 2019 Feb 7. Epub 2019 Feb 7.

Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department, 155# North Nanjing Street, Heping District, Shenyang City, 110001, Liaoning Province, China.

Background: Competitive endogenous RNA (ceRNA) regulation suggested complex network of all transcript RNAs including long noncoding RNAs (lncRNAs), which can act as natural miRNA sponges to inhibit miRNA functions and modulate mRNA expression. Until now, the specific ceRNA regulatory mechanism of lncRNA-miRNA-mRNA in colorectal cancer (CRC) still remains unclear.

Materials And Methods: RNA sequencing data of 478 colon adenocarcinoma cases and 41 controls as well as 166 rectum adenocarcinoma cases and 10 controls were obtained from The Cancer Genome Atlas (TCGA) to investigate the significant changes of lncRNAs, miRNAs and mRNAs in colorectal carcinogenesis. Read More

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http://dx.doi.org/10.1007/s10620-019-05506-9DOI Listing
February 2019
2 Reads

Blockage of the P2X7 Receptor Attenuates Harmful Changes Produced by Ischemia and Reperfusion in the Myenteric Plexus.

Dig Dis Sci 2019 Feb 7. Epub 2019 Feb 7.

Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Dr. Lineu Prestes, 2415, São Paulo, CEP 05508-900, Brazil.

Introduction: Our work analyzed the effects of a P2X7 receptor antagonist, Brilliant Blue G (BBG), on rat ileum myenteric plexus following ischemia and reperfusion (ISR) induced by 45 min of ileal artery occlusion with an atraumatic vascular clamp with 24 h (ISR 24-h group) or 14 d of reperfusion (ISR 14-d group).

Material And Methods: Either BBG (50 mg/kg or 100 mg/kg, BBG50 or BBG100 groups) or saline (vehicle) was administered subcutaneously 1 h after ischemia in the ISR 24-h group or once daily for the 5 d after ischemia in the ISR 14-d group (n = 5 per group). We evaluated the neuronal density and profile area by examining the number of neutrophils in the intestinal layers, protein expression levels of the P2X7 receptor, intestinal motility and immunoreactivity for the P2X7 receptor, nitric oxide synthase, neurofilament-200, and choline acetyl transferase in myenteric neurons. Read More

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http://dx.doi.org/10.1007/s10620-019-05496-8DOI Listing
February 2019

Gastrointestinal Hemorrhage in Patients with Acute Ischemic Stroke: Should Endoscopy Be Within the Scope of Practice?

Dig Dis Sci 2019 Feb 7. Epub 2019 Feb 7.

Division of Gastrointestinal and Liver Diseases, University of Southern California School of Medicine, 1510 San Pablo Street, Los Angeles, CA, 90033, USA.

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http://dx.doi.org/10.1007/s10620-019-05503-yDOI Listing
February 2019

Anterograde Endoscopic Ultrasound-Guided Pancreatic Duct Drainage: A Technical Review.

Dig Dis Sci 2019 Feb 7. Epub 2019 Feb 7.

Section of Digestive Diseases, West Virginia University Medicine, PO Box 9161, One Medical Center Drive, Morgantown, WV, 26506-9161, USA.

The advancement of pancreatic endotherapy has increased the availability of minimally invasive endoscopic pancreatic ductal drainage techniques. In this regard, familiarity with endoscopic ultrasound-guided pancreatic duct drainage (EUS-PDD) is critical for treatment of obstructed pancreatic ductal systems, especially in nonsurgical candidates and in patients desiring a minimally invasive approach. Two distinct forms of EUS-PDD exist, viz. Read More

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http://dx.doi.org/10.1007/s10620-019-05495-9DOI Listing
February 2019
1 Read

ERCP Success Rate and Periampullary Diverticula: The Pocket Makes No Difference.

Dig Dis Sci 2019 Feb 7. Epub 2019 Feb 7.

Baylor College of Medicine Medical Center, McNair Campus, 7200 Cambridge St., 8th Floor, Suite 8B, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s10620-019-05497-7DOI Listing
February 2019

Real-World Experience with Tofacitinib in IBD at a Tertiary Center.

Dig Dis Sci 2019 Feb 7. Epub 2019 Feb 7.

Inflammatory Bowel Disease Center, University of Chicago Medicine, 5841 S. Maryland Ave, MC 4076, Chicago, IL, 60637, USA.

Background And Aims: Many inflammatory bowel disease (IBD) patients do not respond to medical therapy. Tofacitinib is a first-in-class, partially selective inhibitor of Janus kinase, recently approved for treating patients with ulcerative colitis (UC). We describe our experience with the use of tofacitinib for treatment of patients with moderate-to-severe IBD. Read More

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http://link.springer.com/10.1007/s10620-019-05492-y
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http://dx.doi.org/10.1007/s10620-019-05492-yDOI Listing
February 2019
7 Reads

Early Response to Corticosteroid and Baseline C-Reactive Protein Predicts Outcomes in Children with Moderate to Severe Ulcerative Colitis.

Dig Dis Sci 2019 Feb 7. Epub 2019 Feb 7.

Gastroenterology Department, Princess Margaret Hospital for Children, Roberts Road, Subiaco, Perth, WA, 6008, Australia.

Background: Initial response to corticosteroids (CS) is recognized as a strong predictor of outcomes in ulcerative colitis (UC).

Aim: To compare outcomes of early poor responders (PR) versus good responders (GR) to initial CS at 1, 2, and 3 years from diagnosis.

Methods: In this retrospective study, we report longitudinal outcomes of children with moderate-severe UC, initiating oral/IV CS < 1 month of diagnosis and a minimum follow-up (FU) of 1 year. Read More

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http://dx.doi.org/10.1007/s10620-019-05486-wDOI Listing
February 2019

How the "Opt-In" Option Optimizes Organ Donation Rates.

Dig Dis Sci 2019 Feb 7. Epub 2019 Feb 7.

Division of Gastroenterology and Hepatology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

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http://dx.doi.org/10.1007/s10620-019-05483-zDOI Listing
February 2019

Glypican-1 Promotes Tumorigenesis by Regulating the PTEN/Akt/β-Catenin Signaling Pathway in Esophageal Squamous Cell Carcinoma.

Dig Dis Sci 2019 Feb 7. Epub 2019 Feb 7.

Department of Gastroenterology, Zhongshan Hospital, Key Laboratory of Medical Molecule Virology, Ministry of Education and Health, Shanghai Institute of Liver Diseases, Fudan University, Shanghai, 200032, China.

Background And Aims: Glypican-1 (GPC1), a cell-surface heparan sulfate proteoglycan, promotes the pathogenesis of many human cancers. This study focuses on the role of GPC1 in the promotion of cell proliferation and motility in esophageal squamous cell carcinoma (ESCC).

Methods: The expression and distribution of GPC1 were measured in tumor tissues from 248 ESCC patients using immunohistochemical (IHC) assays. Read More

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http://dx.doi.org/10.1007/s10620-019-5461-9DOI Listing
February 2019
1 Read

Off-Label Teduglutide Therapy in Non-intestinal Failure Patients with Chronic Malabsorption.

Dig Dis Sci 2019 Feb 7. Epub 2019 Feb 7.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, 840 S Wood St (M/C 716), Chicago, IL, 60612, USA.

Background: Teduglutide, a glucagon-like peptide 2 analog, has demonstrated efficacy in treating adult patients with short bowel syndrome (SBS) and dependence on parenteral nutrition (PN), but its role in chronic malabsorptive states that do not necessitate PN remains uncertain.

Aims: To evaluate teduglutide use beyond its approved indications and to discuss the results of this adjunctive treatment in patients resistant to established therapy.

Results: This series reports four patients treated with teduglutide off-label. Read More

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http://dx.doi.org/10.1007/s10620-019-5473-5DOI Listing
February 2019
1 Read

Presence of Irritable Bowel Syndrome Symptoms in Quiescent Inflammatory Bowel Disease Is Associated with High Rate of Anxiety and Depression.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Medical College of Wisconsin, Milwaukee, WI, USA.

Background: Inflammatory bowel disease (IBD; Crohn's disease, CD and Ulcerative colitis, UC) and irritable bowel syndrome (IBS) have overlapping symptoms. Few prevalence studies of IBS in quiescent IBD have used colonoscopy with histology to confirm inactive disease. The aims were (1) to determine the percentage of IBD patients in deep remission whose persistent IBS-like symptoms (IBD/IBS+) would cause them to be classified as having active disease, based on the calculation of Harvey Bradshaw Index (HBI) or UC disease activity index (UCDAI); (2) to identify demographic and disease characteristics that are associated with IBD/IBS+. Read More

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http://dx.doi.org/10.1007/s10620-019-05488-8DOI Listing
February 2019
2 Reads

Complications of Long-Term Indwelling Transmural Double Pigtail Stent Placement for Symptomatic Peripancreatic Fluid Collections.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Department of Gastroenterology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0375, Japan.

Background: Endoscopic transmural drainage is performed for symptomatic peripancreatic fluid collections (PPFCs). Long-term transmural double-pigtail stent (DPS) placement is useful in preventing recurrences. There are few reports on the long-term safety of DPS placement. Read More

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http://dx.doi.org/10.1007/s10620-019-05508-7DOI Listing
February 2019
1 Read

Timely Use of Biologics in Early Crohn's Disease: The Return of "Hit Hard and Early"?

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

INSERM U954 and Department of Gastroenterology, Nancy University Hospital, Université de Lorraine, 1 Allée du Morvan, 54 511, Vandœuvre-lès-Nancy, France.

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http://dx.doi.org/10.1007/s10620-019-05504-xDOI Listing
February 2019

Rifaximin for Irritable Bowel Syndrome (IBS) in Gulf War Veterans: Losing the Battle but Winning the War?

Authors:
Lucinda A Harris

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 13400 E. Shea Blvd, Scottsdale, AZ, 85259, USA.

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http://dx.doi.org/10.1007/s10620-019-05505-wDOI Listing
February 2019

Do Elevated Triglycerides Truly Trigger Acute Pancreatitis?

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Division of Gastroenterology, Pancreatitis Center, Johns Hopkins Medical Institutions, 1830 E. Monument Street, Room 428, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1007/s10620-019-05501-0DOI Listing
February 2019
1 Read

Gut Microbiome in HIV Infection: Overcoming Barriers?

Authors:
Brett Williams

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Rush University Infectious Disease, 600 S. Paulina #143, Chicago, IL, USA.

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http://dx.doi.org/10.1007/s10620-019-05500-1DOI Listing
February 2019

Biosimilars in IBD: Similarity Breeds Contented Patients.

Authors:
Vito Annese

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Valiant Clinic & American Hospital, Dubai, UAE.

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http://dx.doi.org/10.1007/s10620-019-05499-5DOI Listing
February 2019

Variations in the Clinical Course of Patients with Herpes Simplex Virus Esophagitis Based on Immunocompetence and Presence of Underlying Esophageal Disease.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Background And Aims: Herpes simplex esophagitis (HSE) is the second most common cause of infectious esophagitis and occurs in both immunocompetent and immunocompromised patients. The aim of this study was to reappraise the clinical course of HSE in different patient populations based on degree of immunocompetence and the presence or absence of underlying esophageal disease.

Methods: Patients with histopathologically confirmed HSE identified from the Mayo Clinic pathology database from 2006 to 2016 were included in this study. Read More

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http://link.springer.com/10.1007/s10620-019-05493-x
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http://dx.doi.org/10.1007/s10620-019-05493-xDOI Listing
February 2019
3 Reads

Analysis of Phenotypic Variables and Differentiation Between Untypical Crohn's Disease and Untypical Intestinal Tuberculosis.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Department of Gastroenterology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.

Background: The differentiation between untypical intestinal tuberculosis (UITB) and untypical Crohn's disease (UCD) is a challenge.

Aims: To analyze phenotypic variables and propose a novel prediction model for differential diagnosis of two conditions.

Methods: A total of 192 patients were prospectively enrolled. Read More

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http://dx.doi.org/10.1007/s10620-019-05491-zDOI Listing
February 2019
1 Read

Efficacy and Safety of Tenofovir Disoproxil Fumarate in Treatment-Naïve Patients with Chronic Hepatitis B in Korea.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, South Korea.

Aims: To evaluate the efficacy and safety of 144-week tenofovir disoproxil fumarate (TDF) therapy in treatment-naïve chronic hepatitis B (CHB) patients in Korean.

Methods: In total, 579 treatment-naïve CHB patients at 11 medical centers were enrolled retrospective and prospective from September 2015 to January 2016 by design (NCT02533544). We evaluated the complete virologic response (CVR) rate and the renal safety of TDF. Read More

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http://dx.doi.org/10.1007/s10620-019-05489-7DOI Listing
February 2019
3 Reads
2.550 Impact Factor

Primary Sclerosing Cholangitis: A Concise Review of Diagnosis and Management.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Section of Gastroenterology, Evans Department of Medicine, Boston University School of Medicine, Suite 7717, 85 E Concord St, Boston, MA, 02118, USA.

Primary sclerosing cholangitis is a rare, chronic cholestatic liver disease characterized by progressive idiopathic stricturing of the biliary system, typically leading to cirrhosis, end-stage liver disease, and colonic or hepatobiliary malignancy. Its presentation is often that of asymptomatic alkaline phosphatase elevation. When symptoms are present, they typically include fatigue, pruritus, or jaundice. Read More

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http://dx.doi.org/10.1007/s10620-019-05484-yDOI Listing
February 2019
1 Read

Alternate Settings for Infusions in Inflammatory Bowel Disease Patients: Homing in on Optimal Care.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Department of Gastroenterology and Hepatology, College of Medicine, University of Arizona, 1501 N. Campbell Avenue, PO Box 245028, Tucson, AZ, 85724-5028, USA.

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http://link.springer.com/10.1007/s10620-019-05480-2
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http://dx.doi.org/10.1007/s10620-019-05480-2DOI Listing
February 2019
2 Reads

Impact of Angiotensin II Signaling Blockade on Clinical Outcomes in Patients with Inflammatory Bowel Disease.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Section of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Chicago, 900 East 57th St., MB #9, Chicago, IL, 60637, USA.

Background: Preclinical data demonstrate that activation of the renin-angiotensin system (RAS) contributes to mucosal inflammation, and RAS inhibition by angiotensin-converting-enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) improves colitis in animal models. Less is known regarding the effects of RAS inhibition on clinical outcomes in inflammatory bowel disease (IBD) patients.

Aim: Evaluate the impact of ACEI and ARB on clinical outcomes in IBD. Read More

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http://dx.doi.org/10.1007/s10620-019-5474-4DOI Listing
February 2019
2 Reads

Magnetic Steering of Capsule Endoscopy Improves Small Bowel Capsule Endoscopy Completion Rate.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

National Clinical Research Center for Digestive Diseases, Department of Gastroenterology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, China.

Background: Capsule endoscopy is currently available as a noninvasive and effective diagnostic modality to identify small bowel abnormalities, with a completion rate to the cecum between 75.1 and 95.6%. Read More

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http://link.springer.com/10.1007/s10620-019-5479-z
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http://dx.doi.org/10.1007/s10620-019-5479-zDOI Listing
February 2019
2 Reads

Case Report of Novel Endoscopic Findings in SMA Syndrome Demonstrated by Video Endoscopy: Visibly Pulsating, Band-Like, Compression in Third Portion of Duodenum, with the Pulsations Corresponding One-for-One with the Radial Pulse and EKG Cycle.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Division of Gastroenterology and Hepatology, Department of Medicine, William Beaumont Hospital, MOB 602, 3535 West Thirteen Mile Road, Royal Oak, MI, 48073, USA.

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http://dx.doi.org/10.1007/s10620-019-5472-6DOI Listing
February 2019

Accuracy of EUS-FNA in Solid Pancreatic Lesions: Sometimes Size Does Matter.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Division of Gastroenterology, Hunter Holmes McGuire Veterans Affairs Medical Center, 111 N, 1201 Broad Rock Blvd, Richmond, VA, 23224, USA.

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http://dx.doi.org/10.1007/s10620-019-5468-2DOI Listing
February 2019

Gastroparesis Versus Functional Dyspepsia: Still Running on Emptying.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s10620-019-5466-4DOI Listing
February 2019
1 Read

Recommendations on the Diagnosis and Initial Management of Acute Variceal Bleeding and Hepatorenal Syndrome in Patients with Cirrhosis.

Dig Dis Sci 2019 Jan 25. Epub 2019 Jan 25.

Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine - DIMED, University of Padova, Via Giustiniani, 2, 35128, Padua, Italy.

Cirrhosis is a serious and life-threatening condition which imposes a significant socioeconomic burden on affected individuals and healthcare systems. Cirrhosis can result in portal hypertension, which may lead to major complications, including acute variceal bleeding and hepatorenal syndrome. Without prompt treatment, these complications may be life-threatening. Read More

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http://dx.doi.org/10.1007/s10620-018-5448-yDOI Listing
January 2019
4 Reads

An Operable, Portable, and Disposable Ultrathin Endoscope for Evaluation of the Upper Gastrointestinal Tract.

Dig Dis Sci 2019 Jan 25. Epub 2019 Jan 25.

Catholic Photomedicine Research Institute, Seoul St. Mary's Hospital, The Catholic University of Korea, 505, Banpo-dong, Seocho-gu, Seoul, 137-070, Korea.

Background And Aims: A prototype of a disposable endoscope (DE) with easy viewing of the esophagus has been developed. The aim of this study was to develop a new version of DE with improved functionality and to assess the feasibility of DE as a screening tool for upper gastrointestinal diseases compared with conventional endoscopes.

Methods: Diagnostic accuracy and maneuverability of DE were evaluated by comparing endoscopy using DE with conventional endoscopy. Read More

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http://dx.doi.org/10.1007/s10620-019-5478-0DOI Listing
January 2019
2 Reads

Laryngopharyngeal Reflux: Weak Acid and Weaker Correlations.

Dig Dis Sci 2019 Jan 25. Epub 2019 Jan 25.

Division of Gastrointestinal and Minimally Invasive Surgery, The Oregon Clinic and The Foundation for Surgical Innovation and Education, 4805 NE Glisan Street, Suite 6N60, Portland, OR, 97213, USA.

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http://dx.doi.org/10.1007/s10620-019-5465-5DOI Listing
January 2019

Empagliflozin for the Treatment of Nonalcoholic Steatohepatitis in Patients with Type 2 Diabetes Mellitus.

Dig Dis Sci 2019 Jan 25. Epub 2019 Jan 25.

Gastroenterology and Hepatology Unit, Department of Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Background And Aims: Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a novel class of drugs that lower glucose by inducing renal glycosuria. We aimed to explore whether SGLT2 inhibitor added to the usual care for patients with type 2 diabetes mellitus (T2DM) and biopsy-proven nonalcoholic steatohepatitis (NASH) will benefit NASH histology.

Methods: In this investigator-initiated, single-arm, open-label, pilot study, nine biopsy-proven NASH patients with T2DM were given empagliflozin 25 mg daily for 24 weeks. Read More

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http://link.springer.com/10.1007/s10620-019-5477-1
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http://dx.doi.org/10.1007/s10620-019-5477-1DOI Listing
January 2019
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Early Postoperative Anti-TNF Therapy Does Not Increase Complications Following Abdominal Surgery in Crohn's Disease.

Dig Dis Sci 2019 Jan 25. Epub 2019 Jan 25.

Department of Surgery, University of Maryland School of Medicine, 29 South Greene Street, 6th Floor, Baltimore, MD, 21201, USA.

Background: The impact of postoperative anti-TNF therapy on infectious complications following Crohn's disease surgery remains controversial. Use of anti-TNF therapy 2-4 weeks postoperatively appears safe, but safety of use within 2 weeks is unknown.

Aims: We sought to evaluate the effect of anti-TNF therapy initiated within 2 weeks of abdominal surgery in patients with Crohn's disease. Read More

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http://dx.doi.org/10.1007/s10620-019-5476-2DOI Listing
January 2019
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Safety of Cold Snare Polypectomy in Patients Receiving Treatment with Antithrombotic Agents.

Dig Dis Sci 2019 Jan 25. Epub 2019 Jan 25.

Department of Gastroenterology and Hepatology, Yokohama City University School of Medicine, Yokohama, Japan.

Background: With the aging of the population and rising incidence of thromboembolic events, the clinical use of antithrombotic agents is also increasing. There are few reports yet on the management of antithrombotic agent use in patients undergoing cold snare polypectomy (CSP).

Aims: The aim of this study was to evaluate whether continued administration of antithrombotic agents in patients undergoing CSP would be associated with an increased rate of delayed post-polypectomy bleeding (DPPB). Read More

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http://dx.doi.org/10.1007/s10620-019-5469-1DOI Listing
January 2019

Musculoskeletal Injuries Are Commonly Reported Among Gastroenterology Trainees: Results of a National Survey.

Dig Dis Sci 2019 Jan 25. Epub 2019 Jan 25.

Division of Gastroenterology and Hepatology, University of Wisconsin-Madison, Madison, USA.

Background: Endoscopy-related musculoskeletal injuries are increasingly recognized among gastroenterologists. While injury rates and risk factors have been studied among practicing gastroenterologists, little is known about rates among trainees during fellowship.

Aims: This study analyzes the prevalence of endoscopy-related overuse injuries and risk factors for injuries among a national sample of gastroenterology (GI) fellows. Read More

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http://link.springer.com/10.1007/s10620-019-5463-7
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http://dx.doi.org/10.1007/s10620-019-5463-7DOI Listing
January 2019
12 Reads