1,344,241 results match your criteria Digestive and Liver Disease[Journal]
Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.
Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Background: The aim of this study was to examine work loss in patients with Crohn's disease.
Methods: Using nationwide registers, we identified incident patients with Crohn's disease (2007-2010) and population comparator subjects without inflammatory bowel disease, matched by age, sex, calendar year, health care region, and education level. We assessed the number of lost workdays due to sick leave and disability pension from 5 years before to 5 years after first diagnosis of Crohn's disease or end of follow-up (September 30, 2015). Read More
Chemosphere 2018 Dec 6;219:321-327. Epub 2018 Dec 6.
School of Life Science, Shanxi University, Taiyuan, Shanxi, 030006, China. Electronic address:
Experiments were carried out to investigate the bioaccumulation and elimination of cadmium (Cd) in tissues (kidney, gills, digestive gland, mantle, visceral mass, foot, adductor muscle and hemolymph) from the freshwater mussel, Anodonta woodiana. The mussels were exposed to subchronic Cd at concentrations of 0.168 and 0. Read More
Bioresour Technol 2018 Dec 4;274:395-402. Epub 2018 Dec 4.
Chemical Engineering Department, Universidad Autonoma de Madrid, Campus de Cantoblanco, 28049 Madrid, Spain. Electronic address:
The potential of hydrothermal carbonization (HTC) as a novel choice for treating microalgal biomass (MAB) was assessed. The hydrochar obtained at 210 °C had a carbon content and a higher heating value (HHV) 1.09 and 1. Read More
Dig Endosc 2018 Dec 14. Epub 2018 Dec 14.
Division of Upper GI and Metabolic Surgery, Department of Surgery, Institute of Digestive Disease.
Endoscopic submucosal dissection (ESD) is technically challenging due to lack of depth perception. This report investigated effect of 3D endoscope for ESD and translate the technique from bench to clinical. In preclinical porcine experiment, the performance of ESD using 3D endoscope was compared between experienced and novice endoscopist. Read More
Curr Opin Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.
Pancreato-Biliary Endoscopy Division and Endosonography Division, Pancreas Translational and Clinical Research Centre, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan.
Purpose Of Review: Alcohol is a type I carcinogen and the WHO stated that it caused 5% of all deaths in 2016, of which 13% because of cancers. Among digestive tract cancers, this association is clear for esophageal, liver and colorectal cancer, and more debated for gastric and pancreatic cancer. The present review will revise recent evidence on epidemiologic association and mechanisms linking alcohol with the risk of esophageal, gastric, colorectal and pancreatic cancers. Read More
Liver Int 2018 Dec 14. Epub 2018 Dec 14.
Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.
Laboratory tests in an asymptomatic 70-year-old Caucasian man revealed biological cholestasis with an increased level of γ-GT. Abdominal tomography showed a mass in the left hepatic lobe, nearly four centimeters in diameter and associated with a dilated left bile duct. PET imaging revealed high glucose uptake. Read More
Dig Endosc 2018 Dec 14. Epub 2018 Dec 14.
Digestive Disease Center, Showa Inan General Hospital, Komagane, Japan.
Colonoscopy has been shown to reduce the risk of colon cancer by enabling the removal of precancerous lesions. Although the cold snare and hot snare polypectomy have similar retrieval rates and complete resection rates, the rates of delayed bleeding tend to be lower with cold snare polypectomy than with hot snare polypectomy, especially for patients taking antithrombotic agents. However, among cold snares there may be differences in terms of the completeness of polyp excision, as complete removal appears more likely with thin-wire dedicated cold snares compared to the traditional, thick-wire cold snares. Read More
Dig Endosc 2018 Dec 14. Epub 2018 Dec 14.
Graduate School of Informatics, Nagoya University, Nagoya, Japan.
With recent breakthroughs in artificial intelligence, computer-aided diagnosis (CAD) for upper gastrointestinal endoscopy is gaining increasing attention. Main research focuses in this field include automated identification of dysplasia in Barrett's esophagus and detection of early gastric cancers. By helping endoscopists avoid missing and mischaracterizing neoplastic change in both the esophagus and stomach, these technologies potentially contribute to solving current limitations of gastroscopy. Read More
Hepatology 2018 Dec 14. Epub 2018 Dec 14.
Gustave Roussy Cancer Campus, Département de Biologie et Pathologie Médicales, Service de Pathologie Moléculaire, Villejuif.
Liver transplantation (LT) has been proposed as a curative treatment in hereditary hemorrhagic telangiectasia (HHT) with severe hepatic involvement. We provide a long-term evaluation of graft status after LT for HHT, with a focus on the risk of recurrence. The present study included all patients prospectively followed-up after LT for HHT in the Lyon liver transplant unit from 1993 to 2010, with a survival of more than 1 year. Read More
Hepatology 2018 Dec 14. Epub 2018 Dec 14.
University of Michigan.
Background/aim: Monotherapy with interferon or nucleoside analog is generally not recommended during the immune tolerant (IT) phase of chronic hepatitis B virus (HBV) infection. Recognition that high HBV DNA levels are associated with hepatocellular carcinoma has increased interest in treating HBV in the IT phase. Small pediatric studies reported efficacy with combination nucleoside analog and interferon therapy. Read More
Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.
Department of Surgical Oncology, Unit of Surgical Oncology of the Esophagus and Digestive Tract, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
Introduction: Lymphocele occurs frequently after regional lymph node dissection. Surgery with multiple lymphatic ligation represents the only reliable treatment for long-standing chronic lymphocele.
Materials And Surgical Technique: We report the case of a man with chronic axillary seroma after axillary lymphadenectomy for melanoma. Read More
Neurogastroenterol Motil 2018 Dec 13:e13509. Epub 2018 Dec 13.
Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
Background: Anxiety and depression are implicated as contributors to abdominal pain in pediatric irritable bowel syndrome (IBS) but is unclear if this pain is associated with other psychological factors. The study objective was to test if the impact of anxiety or depression on IBS symptom severity is mediated by somatization and/or pain catastrophizing.
Methods: We utilized baseline data from local pediatric IBS clinical studies. Read More
APMIS 2019 Jan 22;127(1):27-32. Epub 2018 Nov 22.
Department of Pathology, Copenhagen University Hospital Rigshospitalet, København, Denmark.
Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic ductal adenocarcinoma (PDAC). Current edition of WHO Classification of Tumors of the Digestive System recognizes four different subtypes (gastric, intestinal, pancreatobiliary, and oncocytic) and recommends analysis of mucin expression (MUC1, MUC2, MUC5AC, MUC6) as well as evaluation of architectural and cell differentiation patterns for correct classification. However, there is no consensus on MUC1 expression of IPMN-lesions in the literature. Read More
Colorectal Dis 2018 Dec 13. Epub 2018 Dec 13.
Unit of Digestive of Digestive Surgery, Henri Mondor Hospital, AP-HP, University of Paris Est, UPEC, Créteil, France.
Synchronous, locally-advanced, low rectal cancer and prostate adenocarcinoma together represent a rare and challenging situation for both colorectal surgeons and urologists. The simultaneous resection of both adenocarcinomas after long-course chemoradiation therapy may be associated with a potentially increased postoperative morbidity [1, 2]. On the other hand, simultaneous resection minimises the complications which might be expected if the two procedures are scheduled sequentially. Read More
Am J Med Genet A 2018 Dec 12:e40530. Epub 2018 Dec 12.
Laboratoire de Génétique Médicale, Faculté de Médecine, Université de Strasbourg, Strasbourg cedex, France.
Anorectal anomalies (ARA) are common congenital anomalies. The etiology of ARA is unclear and its pathogenesis is controversial. Cases with ARA often have other non-ARA-associated congenital anomalies. Read More
J Sci Food Agric 2018 Dec 12. Epub 2018 Dec 12.
Food Protein Research and Development Center, Department of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, PR China.
Background: During the last decade, buckwheat is reported to have biological activities and functional properties. The present study investigated the high-polyphenol buckwheat (Fagopyrum esculentum Moench) protein prepared by dual-enzymatic hydrolysis assisting and its physicochemical property, in vitro digestibility and antioxidant activity.
Results: Results showed that the polyphenols of the buckwheat protein (E-BWP) from a synergistic enzymatic action of 1. Read More
Obes Rev 2018 Dec 11. Epub 2018 Dec 11.
Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL, USA.
The rapid decrease in infectious diseases globally has coincided with an increase in the prevalence of obesity and other components of metabolic syndrome. Insulin resistance is a common feature of metabolic syndrome and can be influenced by genetic and non-genetic/environmental factors. The emergence of metabolic syndrome epidemics over only a few decades suggests a more prominent role of the latter. Read More
J Vet Intern Med 2018 Dec 12. Epub 2018 Dec 12.
Clinic for Ruminants, Nantes, France.
Actinobacillosis usually is a sporadic infection that affects the tongue in cattle ("wooden tongue") with possible spread to the digestive tract. Two 4-year-old Rouge-des-Prés cows from a single French beef herd were referred for chronic (2-6 months) swelling and cutaneous nodules in the distal hind limbs. In addition to cutaneous signs, physical examination disclosed cachexia, lameness, lymphadenitis of the hind limbs, and pneumonia in both cows. Read More
Physiol Rep 2018 Dec;6(23):e13937
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.
Inflammation contributes to obesity-related hyperinsulinemia and insulin resistance, which often precede type 2 diabetes. Inflammation is one way that obesity can promote insulin resistance. It is not clear if the extent of obesity, hyperinsulinemia, or hyperglycemia, underpins changes in cellular immunity during diet-induced obesity. Read More
Physiol Rep 2018 Dec;6(23):e13939
Department of Medicine, Division of Nephrology and Hypertension, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
The bioactive peptides of the apelinergic system and its receptor APJ have been shown to play a protective role in experimental cardiovascular and diabetic kidney disease (DKD). Mechanisms of this renoprotective effect remain to be elucidated. In this study, we examined the localization of APJ within the normal kidney and its kidney expression in the db/db model of DKD. Read More
Am J Physiol Gastrointest Liver Physiol 2018 Dec 14. Epub 2018 Dec 14.
University of California at San Francisco, United States.
Radiat Oncol 2018 Dec 14;13(1):246. Epub 2018 Dec 14.
Department of Radiology, Kyoto Prefectural University Graduate School of Medical Science, 465 Kajiicho Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Background: The standard treatment for superficial esophageal cancer (SEC) involving muscularis mucosal (T1a-MM) or submucosal (T1b) invasion has been the surgical resection of the esophagus. However, esophagectomy with extended lymph node dissection is highly invasive. Recent reports have shown that endoscopic submucosal dissection (ESD) followed by chemoradiotherapy (CRT) has promising results and might become a new therapeutic approach. Read More
J Palliat Med 2018 Dec 14. Epub 2018 Dec 14.
5 Jersey City, New Jersey.
Background: Inpatient palliative care consultation (PCC) may reduce 30-day readmissions and inpatient mortality among seriously ill patients.
Objective: To evaluate the impact of timing of PCC on 30-day readmissions and inpatient mortality.
Design: Retrospective, observational study comparing risk-adjusted, observed-to-expected (O/E) 30-day readmissions and inpatient mortality among patients receiving inpatient PCC to all other inpatients. Read More
J Health Pollut 2017 Sep 7;7(15):71-84. Epub 2017 Sep 7.
Department of Chemistry, University of Ibadan, Ibadan, Nigeria.
Background: Soil contamination from heavy metals and polycyclic aromatic hydrocarbons (PAHs) released during informal e-waste processing and disposal poses human and ecological health risks in Nigeria.
Objectives: This study assesses the levels of heavy metals and PAHs in soils of e-waste dumpsites in Lagos and Ibadan, Nigeria.
Methods: Composite soil samples were collected at depths of 0-15 cm, 15-30 cm and 30-45 cm from major e-waste dumpsites in Lagos and Ibadan and analyzed for lead (Pb), cadmium (Cd), copper (Cu), nickel (Ni), zinc (Zn), chromium (Cr) and PAHs to evaluate the potential contaminant contribution from e-waste activities. Read More
J Health Pollut 2016 Jun 16;6(10):84-94. Epub 2016 Jun 16.
Management, Treatment and Promotion of Wastes Laboratory; Faculty of Science, University of Lomé, Togo.
Background: Phosphorites in the mining area of Hahotoé-Kpogamé contain high levels of fluoride that can cause illness among people living close to the mining and processing sites.
Objectives: To assess the distribution of fluoride in the different areas around the phosphorite mining areas in Togo.
Methods: Analyses were performed by molecular absorption spectrometer (HACH DR3800) according to the procedure manual at the geochemical laboratory of the University of Lomé. Read More
Methods Mol Biol 2019 ;1894:313-322
Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA.
Nanoparticles can enter the body via the lungs, the digestive tract, and the skin. The pulmonary effects of nanoparticles and the underlying mechanisms may be investigated by histopathological examination, immunostaining, bronchoalveolar lavage (BAL), and so on. BAL is a simple, fast, and inexpensive method that is commonly used to investigate the immune cells and acellular components in the lungs, which reflect the health state of the lungs. Read More
Esophagus 2018 Dec 13. Epub 2018 Dec 13.
AI Medical Service Inc., Tokyo, Japan.
Background And Aims: The endocytoscopic system (ECS) helps in virtual realization of histology and can aid in confirming histological diagnosis in vivo. We propose replacing biopsy-based histology for esophageal squamous cell carcinoma (ESCC) by using the ECS. We applied deep-learning artificial intelligence (AI) to analyse ECS images of the esophagus to determine whether AI can support endoscopists for the replacement of biopsy-based histology. Read More
Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.
Faculty of Agricultural and Environmental Sciences, University of Rostock, Justus-von-Liebig-Weg 6, 18059, Rostock, Germany.
The anaerobic digestion of wastewater from the cleaning of tank cars transporting food and fodder was investigated in both bench and pilot scales with a single-stage, mesophilic (39 °C), completely mixed process. The promising results lead to the planning and building of a 1200-m full-scale biogas plant at TS-Clean cleaning station in Fahrbinde, Germany. Due to softened water used in the cleaning of the car tanks, the alkalinity in the digester decreased as predicted by the physicochemical model developed for this treatment process. Read More
Rev Endocr Metab Disord 2018 Dec 13. Epub 2018 Dec 13.
Medicover GmbH, Berlin/Hannover, Germany.
The pituitary gland and the hypothalamus can be affected by autoimmune-mediated structural and functional disruption. These autoimmune-mediated diseases occur more commonly in females and are often found during pregnancy or in the post-partum period. Autoimmune diseases can either affect parts of the pituitary or hypothalamus, or can involve both sellar and suprasellar structures. Read More
Obes Surg 2018 Dec 13. Epub 2018 Dec 13.
Department of Digestive Surgery, Archet II Hospital, University of Nice-Sophia-Antipolis, 151 Route de Saint-Antoine, 06200, Nice, France.
Background: Laparoscopic sleeve gastrectomy represents the most performed bariatric procedure in France. Staple line leak is the major short-term complication of the procedure. Patients with persistent fistula after sleeve gastrectomy, after failure of endoscopic and radiological treatment, are candidates for salvage surgery. Read More
AMB Express 2018 Dec 13;8(1):192. Epub 2018 Dec 13.
Liaoning Provincial Key Laboratory of Zoonosis, College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, Liaoning, 110866, People's Republic of China.
Remarkably little information is available about the interaction between the gut microbiota and intestinal immunity in fish and crustaceans. In our study, we used Illumina MiSeq sequencing and real-time quantitative PCR to compare the microbial community and immunity genes expression in the foregut, midgut and hindgut of Chinese mitten crab (Eriocheir sinensis). Our results indicated that the community richness of the midgut is higher than in the foregut or the hindgut, although the bacterial diversity in the hindgut is higher. Read More
Diabetologia 2018 Dec 14. Epub 2018 Dec 14.
Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, 7465 Medical Research Bldg IV, Vanderbilt University Medical Center, 2215 Garland Avenue, Nashville, TN, 37232-0475, USA.
Over the last two decades, improved access to human islets and the development of human islet distribution networks have enabled the use of millions of human islets in hundreds of scientific research projects, leading to a dramatic increase in our understanding of human islet biology. Here we discuss recent scientific advances as well as methodological and experimental challenges that impact human islet quality, experimental outcomes and the reporting of human islets used in scientific publications. In a survey of over 200 scientific publications with human islet experimentation, we found that the reporting of critical information was quite variable, sometimes obscure, and often failed to adequately outline the experiments and results using human islets. Read More
Surg Radiol Anat 2018 Dec 13. Epub 2018 Dec 13.
Department of General and Minimally Invasive Surgery, Centre Hospitalier de Luxembourg, 4, rue Ernest Barblé, 1210, Luxembourg City, Luxembourg.
Purpose: Our aim is to present a rare case of anatomic variation of the arterial blood supply to the liver because preoperative knowledge of hepatic vascular variations is mandatory in hepatic surgery and liver transplantation.
Methods: We present a case of unusual arterial blood supply to the liver, a right hepatic artery coming from the splenic artery, associated to a classical common hepatic artery and a left hepatic artery from the left gastric artery. Preoperative diagnosis was made using CT-scan and 3D reconstruction. Read More
Surg Radiol Anat 2018 Dec 13. Epub 2018 Dec 13.
Department of Plastic, Reconstructive and Aesthetic Surgery, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris, Université Paris Descartes, Paris V, 20 rue Leblanc, 75908, Paris Cedex 15, France.
Purpose: While anatomical variations of the subscapular vessels are frequently encountered during axillary dissection, little is found in the literature. The aim of this cadaveric study was to define arterial and venous anatomical variations and frequencies of the subscapular vascular pedicle and its terminal/afferent vessels in women.
Methods: We performed 80 dissections of the axillary region on forty female formalin-embalmed cadavers. Read More
Food Funct 2018 Dec 14. Epub 2018 Dec 14.
School of Food and Nutrition, Massey Institute of Food Science and Technology, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand.
The digestibility of wheat starch gels in the presence of Mesona chinensis polysaccharide (MCP) was studied. MCP was found to be the most effective polysaccharide in reducing wheat starch digestion in comparison to starch gels of similar hardness containing xanthan, guar, locust bean gum (LBG) and agar. A 33% reduction in the digestibility of intact starch gels containing 5% w/w MCP (after 120 minutes of digestion) was observed and this was attributed to the strengthening of the gels in the presence of high concentration of the polysaccharide. Read More
Curr Opin Endocr Metab Res 2018 Oct 5;2:29-33. Epub 2018 Feb 5.
Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland.
Thyroid stimulating hormone and insulin-like growth factor 1 receptors (TSHRs and IGF1Rs, respectively) interact leading to additive or synergistic stimulation of cellular responses. Recent findings provide evidence that the interaction between TSHRs and IGF1Rs is similar to that described for other G protein-coupled receptors and receptor tyrosine kinases. These types of interactions occur at or proximal to the receptors and are designated "receptor cross-talk. Read More
Front Pediatr 2018 28;6:360. Epub 2018 Nov 28.
Centre National de Référence des Staphylocoques, Institut des Agents Infectieux, Centre de Biologie et de Pathologie Nord, Hospices Civils de Lyon, Lyon, France.
Toxic shock syndromes (TSS) are severe shocks due to staphylococcal or streptococcal infection that require specific treatments. The early recognition of these shocks is crucial to improve their outcomes. The primary objective of this study was to compare characteristics and outcomes of staphylococcal and streptococcal TSS in children, in order to identify putative early clinical diagnostic criteria. Read More
Fatigue 2018 3;6(1):5-19. Epub 2017 Dec 3.
Liver & Energy Metabolism Unit, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
Aims: We sought to examine whether disturbances in central and peripheral circadian rhythms were related to the experience of fatigue in patients with chronic liver disease (CLD).
Methods: Fatigued and non-fatigued patients with compensated CLD were enrolled in a prospective pilot study. Patients underwent a one week evaluation of free-living sleep and physical activity patterns, followed by a 24-hour admission, during which they underwent serial blood sampling, polysomnography, a 6-minute walk test and continuous core temperature measurements under standardized conditions. Read More
Mol Clin Oncol 2018 Dec 4;9(6):651-655. Epub 2018 Oct 4.
First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Neuroendocrine tumors (NETs), belong to a group of neoplasms that arise from neuroendocrine cells and express markers such as synaptophysin and chromogranin A. The digestive system (DS) is the most common site of NET development. The World Health Organization classification divides NETs into low grade (G1-G2) tumors (NETs) and high grade carcinomas [neuroendocrine carcinomas (NECs)], based on mitotic index and histological criteria. Read More
Oncol Lett 2018 Dec 28;16(6):7264-7270. Epub 2018 Sep 28.
Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama 224-8503, Japan.
With recent advances in endoscopic treatment, many T1 colorectal carcinomas (CRCs) are resected endoscopically with a negative margin. However, some lesions exhibit skip lymphovascular invasion (SLVI), which is defined as the discontinuous foci of the tumor cells within the colon wall. The aim of the present study was to reveal the clinicopathological features of T1 CRCs with SLVI and validate the Japanese guidelines regarding SLVI. Read More
Exp Ther Med 2018 Dec 19;16(6):4602-4608. Epub 2018 Sep 19.
Department of Gastroenterology, Xijing Hospital of Digestive Diseases, State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xi'an, Shaanxi 710000, P.R. China.
Despite significant developments in its clinical treatment, the reported incidence and mortality of gastric cancer have exhibited marked increases. The molecular mechanisms of gastric cancer initiation and progression remain to be fully elucidated. The aim of the present study was to identify novel microRNAs (miRNAs/miRs) with a role in the peritoneal metastasis of gastric cancer by comparing the miRNA expression in the gastric cancer cell line GC9811 with that in its variant GC9811-P, a sub-cell line with a high potential for peritoneal metastasis. Read More
Sci Rep 2018 Dec 13;8(1):17834. Epub 2018 Dec 13.
Department of Paediatrics, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada.
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Next to progressive airway disease, CF is also associated with intestinal inflammation and dysbiosis. Ivacaftor, a CFTR potentiator, has improved pulmonary and nutritional status but its effects on the intestinal microbiota and inflammation are unclear. Read More
Oncogene 2018 Dec 13. Epub 2018 Dec 13.
Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China.
Hepatocellular carcinoma (HCC), the major form of liver cancer, has shown increasing incidence and poor prognosis. Adipose tissue is known to function in energy storage and metabolism regulation by the secretion of adipokines. Circular RNAs (circRNAs), a novel type of noncoding RNA, have recently been recognized as key factors in tumor development, but the role of exosome circRNAs derived from adipose tissues has not been defined yet. Read More
Cell Death Differ 2018 Dec 13. Epub 2018 Dec 13.
Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, UK.
Autophagy is a conserved intracellular degradation pathway essential for protein homeostasis, survival and development. Defects in autophagic pathways have been connected to a variety of human diseases, including cancer and neurodegeneration. In the process of macroautophagy, cytoplasmic cargo is enclosed in a double-membrane structure and fused to the lysosome to allow for digestion and recycling of material. Read More
Nat Commun 2018 Dec 13;9(1):5293. Epub 2018 Dec 13.
Department of Pathology and Cell Biology, Columbia University, New York, 10032, NY, USA.
We used allogeneic bone marrow transplantation (BMT) and a mouse multistage cutaneous carcinogenesis model to probe recruitment of bone marrow-derived epithelial cells (BMDECs) in skin tumors initiated with the carcinogen, dimethylbenz[a]anthracene (DMBA), and promoted with 12-O-tetradecanolyphorbol-13-acetate (TPA). BMDECs clustered in the lesional epithelium, expressed cytokeratins, proliferated, and stratified. We detected cytokeratin induction in plastic-adherent bone marrow cells (BMCs) cultured in the presence of filter-separated keratinocytes (KCs) and bone morphogenetic protein 5 (BMP5). Read More
Am J Case Rep 2018 Dec 14;19:1488-1494. Epub 2018 Dec 14.
Department of Digestive Surgery, Tenri Hospital, Tenri, Nara, Japan.
BACKGROUND Colostomy creation via intraperitoneal route is often performed during laparoscopic Hartmann's operation or abdominoperineal resection (APR). Herein, we report 3 rare cases of internal hernia associated with colostomy (IHAC). CASE REPORT The first case involved a 70-year-old man with IHAC after laparoscopic APR. Read More
Am J Kidney Dis 2018 Dec 10. Epub 2018 Dec 10.
Division of Kidney Diseases and Hypertension, George Washington University, Washington, DC. Electronic address:
Rationale & Objective: Traditional risk estimates for atherosclerotic vascular disease (ASVD) and death may not perform optimally in the setting of chronic kidney disease (CKD). We sought to determine whether the addition of measures of inflammation and kidney function to traditional estimation tools improves prediction of these events in a diverse cohort of patients with CKD.
Study Design: Observational cohort study. Read More
BMC Genomics 2018 Dec 13;19(1):928. Epub 2018 Dec 13.
BOA, INRA, Université de Tours, 37380, Nouzilly, France.
Background: The sustainability of poultry farming relies on the development of more efficient and autonomous production systems in terms of feed supply. This implies a better integration of adaptive traits in breeding programs, including digestive efficiency, in order to favor the use of a wider variety of feedstuffs. The aim of the project was to improve the understanding of genes involved in digestive functions by characterizing the transcriptome of different sections of the digestive tract: the junction between the proventriculus and the gizzard, the gizzard, the gastroduodenal junction, and the jejunum. Read More
Biosensors (Basel) 2018 Dec 12;8(4). Epub 2018 Dec 12.
Global Alliance for Rapid Diagnostics. Michigan State University, East Lansing, MI 48824, USA.
A new method using a magnetic nanoparticle-based colorimetric biosensing assay (NCBA) was compared with sputum smear microscopy (SSM) for the detection of pulmonary tuberculosis (PTB) in sputum samples. Studies were made to compare the NCBA against SSM using sputum samples collected from PTB patients prior to receiving treatment. Experiments were also conducted to determine the appropriate concentration of glycan-functionalized magnetic nanoparticles (GMNP) used in the NCBA and to evaluate the optimal digestion/decontamination solution to increase the extraction, concentration and detection of acid-fast bacilli (AFB). Read More
Molecules 2018 Dec 12;23(12). Epub 2018 Dec 12.
IATE, CIRAD, Montpellier SupAgro, INRA, Université de Montpellier, 34060 Montpellier, France.
This experimental work aims at investigating the effects of milling; sieving; and electrostatic separation on the biochemical methane potential of two olive pomaces from traditional olive oil extraction (M) and from a three-phase system (T). Sieving proved to be efficient for increasing the soluble chemical oxygen demand in the smallest fractions of the sieve of both M (62%) and T (78%) samples. The positive fraction following electrostatic separation also enhanced chemical oxygen demand (COD) solubilisation by 94%, in comparison to sample T milled at 4 mm. Read More