4,318 results match your criteria Digestive and Liver Disease[Journal]


Clinical outcomes of endoscopic treatment for gastric epithelial neoplasm in remnant stomach after distal gastrectomy.

Dig Liver Dis 2019 Jan 17. Epub 2019 Jan 17.

Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Backgrounds/aim: We aimed to evaluate the feasibility of endoscopic treatment for gastric epithelial neoplasm in the remnant stomach after distal gastrectomy and compared the clinical outcomes by tumor location and endoscopic treatment modality.

Methods: We reviewed the data of patients who underwent endoscopic treatment for gastric epithelial neoplasms in the remnant stomach after distal gastrectomy between January 1996 and August 2013. The treatments included endoscopic resection or argon plasma coagulation. Read More

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http://dx.doi.org/10.1016/j.dld.2018.11.030DOI Listing
January 2019

Potential biomarkers to predict outcome of faecal microbiota transfer for recurrent Clostridioides difficile infection.

Dig Liver Dis 2019 Jan 26. Epub 2019 Jan 26.

Department I of Internal Medicine, University Hospital of Cologne, Germany; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Germany. Electronic address:

Background & Aims: Faecal microbiota transplantation (FMT) has proven high clinical efficacy in the management of recurrent Clostridioides difficile infection (rCDI) with cure rates of over 80% after a single treatment. Nevertheless, the reasons for failure in the remaining 20% remain elusive. The aim of the present study was to investigate different potential predictors of response to FMT. Read More

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http://dx.doi.org/10.1016/j.dld.2019.01.012DOI Listing
January 2019

Albumin-Bilirubin (ALBI) as an accurate and simple prognostic score for chronic hepatitis B-related liver cirrhosis.

Dig Liver Dis 2019 Jan 26. Epub 2019 Jan 26.

Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China. Electronic address:

Background: The Albumin-Bilirubin (ALBI) score was developed to predict the long-term prognosis of hepatocellular carcinoma patients. We aimed to investigate the performance of ALBI for predicting severity and long-term prognosis of chronic hepatitis B-related liver cirrhosis (CHB-LC).

Methods: CHB-LC patients were enrolled from two medical centers between 2011 and 2017. Read More

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http://dx.doi.org/10.1016/j.dld.2019.01.011DOI Listing
January 2019

Comparison of EUS-guided versus percutaneous and transjugular approaches for the performance of liver biopsies.

Dig Liver Dis 2019 Jan 22. Epub 2019 Jan 22.

Division of Gastroenterology, Oregon Health & Science University, Portland, OR, United States. Electronic address:

Background: Liver biopsy through endoscopic ultrasound (EUS) has become a novel approach for tissue acquisition. We aim to evaluate the adequacy of EUS-guided liver biopsies in comparison to those obtained through interventional radiology (IR) techniques.

Methods: A retrospective single-center analysis was performed of all IR (transjugular or image-guided percutaneous) and EUS-guided liver biopsies performed at an academic medical center from January 2016 to January 2018. Read More

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http://dx.doi.org/10.1016/j.dld.2019.01.006DOI Listing
January 2019
1 Read

Meta-analysis of circulating microRNAs for the diagnosis of hepatocellular carcinoma.

Dig Liver Dis 2018 Dec 28. Epub 2018 Dec 28.

Department of Hepatobiliary-Pancreatic Surgery, China-Japan Union Hospital of Jilin University, Changchun, China. Electronic address:

Aim: There are no existing biomarkers that demonstrate very reliable performance in the diagnosis of hepatocellular carcinoma (HCC), especially in the early stage. Studies have shown that numerous aberrantly expressed circulating microRNAs (miRNAs) can be used as a diagnostic tool for HCC; however, these studies have produced inconsistent results.

Methods: We performed a meta-analysis to summarize the diagnostic accuracy of circulating miRNAs, alpha-fetoprotein (AFP), and AFP combined with miRNAs in differentiating HCC patients from non-HCC controls, healthy controls and chronic liver disease controls. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15908658183143
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http://dx.doi.org/10.1016/j.dld.2018.12.011DOI Listing
December 2018
2 Reads
2.963 Impact Factor

Pathogenesis of hypothyroidism-induced NAFLD: Evidence for a distinct disease entity?

Dig Liver Dis 2019 Jan 2. Epub 2019 Jan 2.

Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.

Nonalcoholic fatty liver disease (NAFLD), the most common liver disease worldwide, may be associated with primary hypothyroidism. However, the pathogenesis underlying such an association is complex and not completely understood. Here, we specifically discuss the pathogenic mechanisms potentially involved in hypothyroidism-induced NAFLD. Read More

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http://dx.doi.org/10.1016/j.dld.2018.12.014DOI Listing
January 2019
1 Read

Association of time to colonoscopy after a positive fecal test result and fecal hemoglobin concentration with risk of advanced colorectal neoplasia.

Dig Liver Dis 2018 Dec 23. Epub 2018 Dec 23.

Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

Background: We evaluated the risk of advanced colorectal neoplasia (ACRN) and colorectal cancer (CRC) according to time to colonoscopy after positive fecal immunochemical test (FIT), fecal hemoglobin concentration, and combination of both.

Methods: We analyzed the records of 2362 patients aged ≥50 years who underwent colonoscopy because of a positive FIT result through the National Cancer Screening Program of Korea.

Results: ACRN risk increased with increasing time to colonoscopy after a positive FIT (17. Read More

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http://dx.doi.org/10.1016/j.dld.2018.12.008DOI Listing
December 2018

A new algorithm for predicting long-term survival in chronic hepatitis B patients with variceal bleeding after endoscopic therapy.

Dig Liver Dis 2019 Jan 14. Epub 2019 Jan 14.

Department of gastroenterology, Beijing Ditan Hospital, Capital Medical University, Beijing, China. Electronic address:

Background And Aims: A predictive algorithm for survival is urgently needed in clinical practice. This study aimed to establish an algorithm to predict long-term survival in chronic hepatitis B (CHB) patients with hepatic cirrhosis and variceal bleeding after endoscopic therapy.

Methods: This was a retrospective study in which 603 patients who followed-up for three years were randomly assigned into a training cohort and a validation cohort in a 2:1 ratio. Read More

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http://dx.doi.org/10.1016/j.dld.2019.01.004DOI Listing
January 2019
3 Reads

The size of well differentiated pancreatic neuroendocrine tumors correlates with Ki67 proliferative index and is not associated with age.

Dig Liver Dis 2019 Jan 22. Epub 2019 Jan 22.

Pancreatic Surgery Unit, Pancreas Translational & Clinical Research Center, San Raffaele Scientific Institute, "Vita-Salute" University, Milan, Italy. Electronic address:

Background: Concerns exist about a conservative management of well-differentiated nonfunctioning small pancreatic neuroendocrine tumors (NF-PanNET) in young patients and when preoperative Ki67 proliferative index is ≥3%.

Aim: To evaluate an association between age, tumor size and grading in patients with sporadic NF-PanNET who underwent curative resection.

Methods: Patients who underwent surgery for sporadic NF-PanNET (excluding G3) were retrospectively analyzed. Read More

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http://dx.doi.org/10.1016/j.dld.2019.01.008DOI Listing
January 2019
1 Read

Prospective evaluation of ERCP performance in an Italian regional database study.

Dig Liver Dis 2019 Jan 17. Epub 2019 Jan 17.

Division of Gastroenterology and Gastrointestinal Endoscopy, Vita Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Background: Prospective studies about endoscopic retrograde cholangio-pancreatography (ERCP) in a community setting are rare.

Aim: To assess success and complication rates of routinely-performed ERCP in a regional setting, and the priority quality indicators for ERCP practice.

Methods: Prospective region wide observational study on consecutive patients undergoing ERCP during a 6-month period. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15908658193000
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http://dx.doi.org/10.1016/j.dld.2018.12.021DOI Listing
January 2019
1 Read

Correlation between endoscopic and histological validated scoring indices in Crohn's disease.

Dig Liver Dis 2019 Jan 22. Epub 2019 Jan 22.

Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, PR China.

Background: It is of crucial importance to evaluate disease activity by means of endoscopy and histopathology in Crohn's disease (CD). Nonetheless, correlation between endoscopic and histological validated indices has not been verified.

Aims: We aim to correlate the Simple Endoscopic Score for Crohns disease (SES-CD) with two validated widely used histological indices in patients with established CD. Read More

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http://dx.doi.org/10.1016/j.dld.2019.01.010DOI Listing
January 2019
1 Read

Quality of life during one year of postoperative prophylactic drug therapy after intestinal resection in Crohn's patients: Results of the APPRECIA trial.

Dig Liver Dis 2019 Jan 14. Epub 2019 Jan 14.

Center for Biomedical Research in the Liver and Digestive Diseases Network (CIBERehd), Carlos III Health Institute, Madrid, Spain; Digestive Diseases Unit, University and Polytechnic Hospital of La Fe, Valencia, Spain.

Background: In APPRECIA trial, Crohn's disease (CD) patients undergoing intestinal resection were randomized to postoperative adalimumab (ADA) or azathioprine (AZA).

Aims: To evaluate health-related quality of life (HRQoL) in APPRECIA trial.

Methods: HRQoL was evaluated using disease-specific shortened Spanish version of the IBDQ (SIBDQ-9) and generic European Quality of Life-5 Dimensions (EQ-5D) questionnaires, completed at baseline and at weeks 24 and 52. Read More

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http://dx.doi.org/10.1016/j.dld.2019.01.002DOI Listing
January 2019
1 Read

Lesson from epidemiology of paediatric Crohn's disease.

Dig Liver Dis 2019 Jan 17. Epub 2019 Jan 17.

Women's and Children's Department, Sapienza University of Rome, Italy.

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http://dx.doi.org/10.1016/j.dld.2018.12.020DOI Listing
January 2019

Angiotensin II and tumor necrosis factor-α stimulate the growth, migration and invasion of BEL-7402 cells via down-regulation of GRK2 expression.

Dig Liver Dis 2019 Feb 20;51(2):263-274. Epub 2018 Jun 20.

Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei, Anhui, PR China. Electronic address:

Purpose: To investigate the effects of angiotensin II (Ang II) and tumor necrosis factor-α (TNF-α) on the biological characteristics of hepatocellular carcinoma (HCC) cells and the associated changes in G protein-coupled receptor kinase 2 (GRK2) expression.

Methods: The mean serum levels of Ang II and TNF-α in normal subjects and patients with benign liver tumors (BLTs) and HCC were evaluated by enzyme-linked immunosorbent assay (ELISA), and liver samples from the patients with HCC and HCC mice were used to assess the protein levels of both cytokines, their major receptors and GRK2. In addition, the dynamics of Bel-7402 cells were determined with cell counting kit-8 (CCK-8) and Transwell experiments, while the levels of the primary cytokine receptors Ang II type-1 receptor (AT1R) and type-2 receptor (AT2R) as well as TNF receptor 1 (TNFR1) were detected by flow cytometry (FCM). Read More

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http://dx.doi.org/10.1016/j.dld.2018.06.007DOI Listing
February 2019
1 Read

Successful outcome of the transitional process of inflammatory bowel disease from pediatric to adult age: A five years experience.

Dig Liver Dis 2018 Dec 10. Epub 2018 Dec 10.

Gastroenterology, Department of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.

Introduction And Aim: The transitional process of young patients affected by inflammatory bowel disease from pediatric to adult care is a crucial step. Our study aimed to investigate the 1-year success outcome of this transitional process.

Methods: From 2013 to 2018, we evaluated the transitional process of patients with Crohn's disease or ulcerative colitis. Read More

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http://dx.doi.org/10.1016/j.dld.2018.11.034DOI Listing
December 2018
5 Reads

Evaluation of three "beyond Baveno VI" criteria to safely spare endoscopies in compensated advanced chronic liver disease.

Dig Liver Dis 2019 Jan 11. Epub 2019 Jan 11.

CRC "A. M. e A. Migliavacca" Center for Liver Disease, Division of Gastroenterology and Hepatology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

Background: Liver stiffness measurement (LSM) <20 kPa and platelet count >150,000/mm exclude varices needing treatment (VNT) in viral compensated advanced chronic liver disease (cACLD), saving-up to 20-25% endoscopies (Baveno VI criteria). Refinements of such criteria to further reduce endoscopies and an approach without LSM (Platelet 150/MELD 6) were later proposed.

Aims: To assess LSM 25/platelet 125, LSM 25/platelet 110 (Expanded-Baveno VI) and Platelet 150/MELD 6 accuracy versus Baveno VI criteria, and the impact of platelet count variability on criteria accuracy in all-etiologies cACLD. Read More

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http://dx.doi.org/10.1016/j.dld.2018.12.025DOI Listing
January 2019

Micro-elimination of hepatitis C virus infection in β-Thalassaemia major patients: Positively moving towards the World Health Organisation 2030 eradication goal.

Dig Liver Dis 2019 Jan 14. Epub 2019 Jan 14.

Division of Internal Medicine and Hepatology, Humanitas Research Hospital, Rozzano; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

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http://dx.doi.org/10.1016/j.dld.2019.01.001DOI Listing
January 2019

Uncommon appearance of concurrent liver cirrhosis and chronic pancreatitis: The alcohol metabolism theory.

Dig Liver Dis 2019 Jan 11. Epub 2019 Jan 11.

Institute for Translational Medicine, University of Pécs, Medical School, János Szentágothai Research Centre, Pécs, Hungary; Momentum Gastroenterology Multidisciplinary Research Group, Hungarian Academy of Sciences University of Szeged, Szeged, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.dld.2018.12.023DOI Listing
January 2019
1 Read

Nonalcoholic fatty liver disease is associated with breast cancer in nonobese women.

Dig Liver Dis 2019 Jan 9. Epub 2019 Jan 9.

Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Growing evidence supports that nonalcoholic fatty liver disease (NAFLD) is associated with extrahepatic cancers. Nonalcoholic fatty liver disease (NAFLD) and breast cancer share similar risk factors, including obesity.

Aim: The aim of this case-control study was to investigate the association between NAFLD and breast cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15908658193000
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http://dx.doi.org/10.1016/j.dld.2018.12.024DOI Listing
January 2019
3 Reads

Premedication as primary prophylaxis does not influence the risk of acute infliximab infusion reactions in immune-mediated inflammatory diseases: A systematic review and meta-analysis.

Dig Liver Dis 2018 Dec 13. Epub 2018 Dec 13.

Department of Biostatistics, Amiens University Hospital, Amiens, France.

Introduction: Up to 25% of patients treated with infliximab experience hypersensitivity reactions. Prophylactic premedication prior to infliximab infusion, comprising corticosteroids and/or antihistamines, is widely used in clinical practice but its efficacy has recently been called into question due to the lack of pathophysiological rationale and validation by controlled trials.

Materials And Methods: We conducted a comprehensive literature search of multiple electronic databases from inception to June 2017 to identify studies reporting the impact of corticosteroid and/or antihistamine premedication on the risk of acute (<24 h) hypersensitivity reaction to infliximab in immune-mediated inflammatory diseases (IMIDs). Read More

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http://dx.doi.org/10.1016/j.dld.2018.12.002DOI Listing
December 2018

Epidemiological features and disease-related concerns of a large cohort of Italian patients with active Crohn's disease.

Dig Liver Dis 2019 Jan 3. Epub 2019 Jan 3.

IBD Unit, University of Bologna, Emilia-Romagna Region IBD Reference Center, S. Orsola-Malpighi Hospital, Bologna, Italy.

Background-aims: The SOLE study was conducted on a large cohort of Italian patients with moderate-severe Crohn's disease (CD) to assess epidemiological and disease characteristics and their correlation with disease-related worries, treatment satisfaction and adherence, workability.

Methods: The following tools were used over 12 months to assess: Results were correlated with demographic and clinical variables with linear regression models.

Results: 552 patients with active CD (51% men) were recruited. Read More

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http://dx.doi.org/10.1016/j.dld.2018.12.019DOI Listing
January 2019
3 Reads

Time to revise the definition of NAFLD: A purist vision.

Dig Liver Dis 2019 Jan 3. Epub 2019 Jan 3.

Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.dld.2018.12.018DOI Listing
January 2019

Association of vitamin D levels and vitamin D-related gene polymorphisms with liver fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease.

Dig Liver Dis 2019 Jan 9. Epub 2019 Jan 9.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.

Background: Vitamin D has promising anti-proliferative and anti-fibrotic properties, but its clinical utility in nonalcoholic fatty liver disease (NAFLD) is unclear.

Aims: This study aimed to clarify the association between vitamin D levels, single nucleotide polymorphisms (SNPs) in vitamin D-related genes, and the histopathological severity of disease in patients with biopsy-proven NAFLD.

Methods: SNPs in CYP2R1, DHCR7, vitamin D binding protein (GC), CYP27B1, and vitamin D receptor (VDR) were determined for 229 consecutive patients with biopsy-proven NAFLD. Read More

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http://dx.doi.org/10.1016/j.dld.2018.12.022DOI Listing
January 2019

HepaDisk - A new quality of life questionnaire for HCV patients.

Dig Liver Dis 2018 Dec 23. Epub 2018 Dec 23.

Cronic Infectious Diseases Unit, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

Background: Since most patients with hepatitis C virus (HCV) infection now receive treatment irrespective of liver disease severity, special attention to patient quality of life (QoL), including psycho-social aspects, is required. No QoL questionnaire is specific for patients with HCV.

Aims: To develop and validate a short Italian questionnaire (HepaDisk) assessing the QoL of patients affected by HCV with intuitive graphic results that is understandable by patients and physicians. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15908658183130
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http://dx.doi.org/10.1016/j.dld.2018.12.009DOI Listing
December 2018
4 Reads

Comparison of asymmetric (low morning-dose) and standard split-dose regimen of PEG plus bisacodyl for bowel preparation: A randomized controlled trial.

Dig Liver Dis 2018 Dec 28. Epub 2018 Dec 28.

Department of Gastroenterology, Rho and Garbagnate Milanese Hospital, ASST Rhodense, Milano, Italy. Electronic address:

Background: Reducing the morning dose of PEG solution may be a reliable strategy to improve the patient compliance of split-dose regimens without affecting efficacy of bowel cleansing.

Aims: to compare the efficacy for bowel cleansing of an asymmetric split-dose regimen (25% of the dose on the day of colonoscopy and 75% on the day before) with the standard split-dose regimen.

Methods: Outpatients were enrolled in a randomized, single-blind, non-inferiority clinical trial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15908658183144
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http://dx.doi.org/10.1016/j.dld.2018.12.012DOI Listing
December 2018
6 Reads

Feasibility and reproducibility of liver and pancreatic stiffness in patients with alcohol-related liver disease.

Dig Liver Dis 2019 Jan 3. Epub 2019 Jan 3.

Department of Internal Medicine 1, Hospital of the Goethe University, Frankfurt, Germany.

Background: To date no studies evaluated liver stiffness and pancreatic stiffness by shear-wave elastography, in alcoholic liver disease setting.

Aims: To assess feasibility and reproducibility of Shear-wave elastrography in measuring liver and pancreatic stiffness in alcoholic liver disease and investigate the correlation among liver and pancreatic stiffness and clinical data.

Methods: Liver and pancreatic stiffness were measured by elastography (2 examiners) in patients with alcoholic liver disease and in healthy volunteers, for reference values. Read More

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http://dx.doi.org/10.1016/j.dld.2018.12.017DOI Listing
January 2019
1 Read

Impact of the direct-acting antiviral agents (DAAs) on chronic hepatitis C in Sardinian patients with transfusion-dependent Thalassemia major.

Dig Liver Dis 2019 Jan 3. Epub 2019 Jan 3.

Thalassemia Unit, 'A. Cao' Hospital, A.O. 'G. Brotzu', Cagliari, Italy. Electronic address:

Background And Aims: Direct antiviral agents (DAAs) have revolutionised the standard of care for the treatment of hepatitis even in patients with hemoglobinopathies. The aim of this study is to show how, thanks to DAAs, HCV infection has been substantially eradicated in one of the biggest Centres for the management of Thalassemia in Europe.

Methods: Thalassemia major patients regularly transfused and iron chelated in Cagliari (Italy) who were HCV-RNA positive were evaluated for the potential prescription of antiviral therapy. Read More

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http://dx.doi.org/10.1016/j.dld.2018.12.016DOI Listing
January 2019
3 Reads

Adherence to European Society of Gastrointestinal Endoscopy recommendations of endoscopists performing small bowel capsule endoscopy in Italy.

Dig Liver Dis 2018 Dec 10. Epub 2018 Dec 10.

Division of Oncological Gastroenterology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.

Background: The European Society of Gastrointestinal Endoscopy (ESGE) has recently issued a technical review focused on small bowel capsule endoscopy (SBCE).

Aim: To compare SBCE current practice in Italy to ESGE technical recommendations.

Material And Methods: A dedicated per-centre semi-quantitative questionnaire was prepared by a group of SBCE experts. Read More

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http://dx.doi.org/10.1016/j.dld.2018.11.031DOI Listing
December 2018
2 Reads

A neonate with pneumoperitoneum and cyanosis of lower limbs skin during esophagogastroduodenoscopy.

Dig Liver Dis 2019 Jan 3. Epub 2019 Jan 3.

Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan.

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http://dx.doi.org/10.1016/j.dld.2018.12.015DOI Listing
January 2019
3 Reads

"Are the Expanded Baveno VI Criteria really safe to screen compensated cirrhotic patients for high-risk varices?"

Dig Liver Dis 2018 Dec 28. Epub 2018 Dec 28.

Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S15908658183144
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http://dx.doi.org/10.1016/j.dld.2018.12.013DOI Listing
December 2018
5 Reads

Early metabolic response to chemoradiotherapy by interim FDG PET/CT is associated with better overall survival and histological response in esophageal cancers.

Dig Liver Dis 2018 Dec 23. Epub 2018 Dec 23.

Department of Radiation Oncology, Saint Louis Hospital, Paris, France. Electronic address:

Background: Early assessment of response to neoadjuvant chemoradiotherapy (CRT) is crucial in determining the most suitable treatment strategy in locally advanced oesophageal cancer (LAEC).

Aims: We evaluated the impact of early metabolic response during CRT on overall survival (OS) and histological response.

Methods: Patients with biopsy-proven oesophageal carcinoma underwent FDG PET/CT with evaluation of the standardized uptake value (SUV) before any treatment and during CRT after 20 Gy. Read More

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http://dx.doi.org/10.1016/j.dld.2018.12.006DOI Listing
December 2018
1 Read

Colon stenting as "Bridge-to-surgery": A further piece of the puzzle toward…?

Dig Liver Dis 2018 Dec 28. Epub 2018 Dec 28.

Gastroenterology, Department of Clinical Medicine and Surgery, School of Medicine Federico II of Naples, Naples, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S15908658183143
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http://dx.doi.org/10.1016/j.dld.2018.11.167DOI Listing
December 2018
7 Reads

Genetic depletion of Soat2 diminishes hepatic steatosis via genes regulating de novo lipogenesis and by GLUT2 protein in female mice.

Dig Liver Dis 2018 Dec 23. Epub 2018 Dec 23.

Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Metabolism Unit, Department of Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden; Patient Area Nephrology and Endocrinology, Inflammation and Infection Theme, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

Depletion of the cholesterol esterifying enzyme acyl-Coenzyme A: cholesterol acyltransferase 2 (ACAT2, encoded by Soat2) protects mice from atherosclerosis, diet-induced hypercholesterolemia, and hepatic steatosis when fed high-cholesterol diet. The glucose transporter 2 (GLUT2) represents the main gate of glucose uptake by the liver. Lipid synthesis from glucose (de novo lipogenesis; DNL) plays a pivotal role in the development of hepatic steatosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15908658183130
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http://dx.doi.org/10.1016/j.dld.2018.12.007DOI Listing
December 2018
5 Reads

Deep remission on magnetic resonance imaging impacts outcomes of perianal fistulizing Crohn's disease.

Dig Liver Dis 2018 Dec 23. Epub 2018 Dec 23.

Department of Radiology, Rouen University Hospital, Normandie Univ, UNIROUEN, Quantif-LITIS EA 4108, Rouen cedex, France. Electronic address:

Background: The long-term management of perianal Crohn's disease for patients on anti-TNF-α therapy remains challenging.

Aim: To evaluate the long-term course and complications of patients with perianal fistulas treated with anti-TNF-α based on their clinical remission and healing on MRI.

Methods: Patients were evaluated clinically and by MRI. Read More

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http://dx.doi.org/10.1016/j.dld.2018.12.010DOI Listing
December 2018
5 Reads

Long-term outcome of pediatric-onset Crohn's disease: A population-based cohort study.

Dig Liver Dis 2018 Dec 23. Epub 2018 Dec 23.

Public Health, Epidemiology and Economic Health Unit, Epimad Registry, Maison Régionale de la Recherche Clinique, Université Lille Nord de France, Lille, France; Inserm, Lille University, LIRIC UMR 995, Team 5, France. Electronic address:

Background: Pediatric-onset Crohn's disease (CD) may represent a more severe form of disease. The aim of this study was to describe long-term outcome and identify associated risk factors of complicated behavior in a large population-based pediatric-onset CD cohort.

Patients And Methods: Cases included all patients recorded in the EPIMAD registry diagnosed with definite or probable CD between January 1988 and December 2004, under the age of 17 years at the time of diagnosis, with at least two years of follow-up. Read More

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http://dx.doi.org/10.1016/j.dld.2018.11.033DOI Listing
December 2018
6 Reads

Comparison and correlation of fibrosis stage assessment by collagen proportionate area (CPA) and the ELF panel in patients with chronic liver disease.

Dig Liver Dis 2018 Dec 19. Epub 2018 Dec 19.

Regenerative Medicine and Fibrosis Group, Institute for Liver and Digestive Health, University College London, Royal Free Campus London, United Kingdom; Sheila Sherlock Liver Centre, Royal Free Hospital, London, United Kingdom.

Background: Fibrosis progression is the common consequence of most chronic liver diseases.

Aims: To evaluate the performance of Collagen Proportionate Area (CPA) and ELF using Ishak's score in patients with chronic liver diseases.

Methods: Retrospective analysis of medical data from patients on whom a liver biopsy was performed as part of the diagnostic assessment. Read More

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http://dx.doi.org/10.1016/j.dld.2018.12.005DOI Listing
December 2018
3 Reads

Characteristics of Inflammatory Bowel Disease in patients of Roma/Gypsy ethnicity. A case-control study.

Dig Liver Dis 2018 Dec 19. Epub 2018 Dec 19.

IBD Unit, Department of Gastroenterology, University Hospital «Germans Trias i Pujol», Badalona, Catalunya, Spain; Centre for Network Biomedical Research in Liver and Digestive Diseases (CIBEREHD), Madrid, Spain.

Background: Peculiarities of Inflammatory Bowel Disease (IBD) have been explored in ethnic groups, such as Asians, Hispanics, and Afro-Americans, but not in other ethnic minorities, such as Roma/Gypsies.

Methods: In a retrospective, hospital-based study, all adult Roma/Gypsy patients included in the IBD databases of seven Spanish centres were identified as cases. For each Roma/Gypsy patient, a Caucasian patient, matched for several demographic features, was searched as a control. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15908658183127
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http://dx.doi.org/10.1016/j.dld.2018.12.004DOI Listing
December 2018
2 Reads

Hepatic encephalopathy 2018: A clinical practice guideline by the Italian Association for the Study of the Liver (AISF).

Dig Liver Dis 2019 Feb 12;51(2):190-205. Epub 2018 Dec 12.

Clinical Pharmacology & Digestive Pathophysiology Unit, Department of Clinical & Experimental Medicine, University of Parma, Italy.

Hepatic encephalopathy (HE) is a common, worrisome and sometimes difficult to manage complication of end-stage liver disease. HE is often recurrent, requiring multiple hospital admissions. It can have serious implications in terms of a patient's ability to perform complex tasks (for example driving), their earning capacity, their social and family roles. Read More

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http://dx.doi.org/10.1016/j.dld.2018.11.035DOI Listing
February 2019
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Efficacy and safety of anticoagulation for atrial fibrillation in patients with cirrhosis: A systematic review and meta-analysis.

Dig Liver Dis 2018 Dec 13. Epub 2018 Dec 13.

Department of Medicine, University of Mississippi Medical Center, MS, USA.

Objective: The atrial fibrillation-related stroke is clearly prevented by anticoagulation treatment, however, management of anticoagulation for AF in patients with cirrhosis represents a challenge due to bleeding concerns. To address this issue, a systematic review and meta-analysis of the literature was performed.

Methods: A literature search for studies reporting the incidence of AF in patients with cirrhosis was conducted using MEDLINE, EMBASE and Cochrane Database, from inception through July 2018. Read More

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http://dx.doi.org/10.1016/j.dld.2018.12.001DOI Listing
December 2018
1 Read
2.963 Impact Factor

Risk of advanced lesions in patients with branch-duct IPMN and relative indications for surgery according to European evidence-based guidelines.

Dig Liver Dis 2018 Dec 10. Epub 2018 Dec 10.

Department of Gastroenterology and Hepatology, University Hospitals St-Luc, Brussels, Belgium.

Background: European evidence-based guidelines proposed surgery for branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) based on the presence of 1-2 relative indications, depending on the comorbidity burden.

Aims: To assess the accuracy of the guidelines in patients with relative indications in a surgical cohort of demonstrated BD-IPMNs.

Methods: This report describes a multi-centre, observational, retrospective study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15908658183126
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http://dx.doi.org/10.1016/j.dld.2018.11.028DOI Listing
December 2018
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Harmonization of quality of care in an IBD center impacts disease outcomes: Importance of structure, process indicators and rapid access clinic.

Dig Liver Dis 2018 Dec 3. Epub 2018 Dec 3.

Inflammatory Bowel Disease Centre, Division of Gastroenterology, McGill University Health Centre (MUHC), Montreal, Quebec, Canada; 1st Department of Medicine, Semmelweis University, Budapest, Hungary. Electronic address:

Background And Aims: We aimed to evaluate the quality of care at a tertiary inflammatory bowel disease (IBD) center using quality of care indicators (QIs) including patient assessment strategy, monitoring, treatment decisions and outcomes.

Methods: We retrospectively reviewed the quality of care pre- and post-referral and during follow-up at the at the McGill University Health Center (MUHC) IBD center. Consecutive patients were included presenting with an outpatient visit ('index visit') between July and December 2016. Read More

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http://dx.doi.org/10.1016/j.dld.2018.11.013DOI Listing
December 2018
1 Read

Risk and survival of third primary cancers in a population-based cohort of gastric cancer patients.

Dig Liver Dis 2018 Dec 12. Epub 2018 Dec 12.

EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal; Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal. Electronic address:

Background: The growing number of gastric cancers together with improved survival resulted in an increasing population of survivors at risk of multiple primary cancers.

Aims: To estimate the 10-year risk and survival of third primary cancers (TPCs) among gastric first primary cancers (FPCs).

Methods: Gastric FPCs from the Portuguese North Region Cancer Registry, diagnosed in 2000-2006 (n = 7409), were followed for a TPC (31/12/2012), and for all-cause death (31/12/2017). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15908658183127
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http://dx.doi.org/10.1016/j.dld.2018.12.003DOI Listing
December 2018
8 Reads

Factors affecting vitamin D deficiency in active inflammatory bowel diseases.

Dig Liver Dis 2018 Dec 7. Epub 2018 Dec 7.

Department of Internal Medicine and Medical Specialties, Gastroenterology, Sapienza University of Rome, Rome, Italy.

Background: Hypovitaminosis D is prevalent in inflammatory bowel disease (IBD) and may be associated with disease activity.

Aim: This study evaluated vitamin D (VitD) status in an Italian cohort of IBD patients, not taking VitD supplementation. We investigated risk factors for VitD deficiency and its correlation with disease activity. Read More

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http://dx.doi.org/10.1016/j.dld.2018.11.036DOI Listing
December 2018
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Epidemiology of primary biliary cholangitis in Italy: Evidence from a real-world database.

Dig Liver Dis 2018 Nov 17. Epub 2018 Nov 17.

Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Viale del Policlinico 155, 00185, Rome, Italy. Electronic address:

Background: Primary biliary cholangitis is an autoimmune disease affecting the interlobular bile ducts. Limited information is available on its epidemiology and treatment in Italy.

Aims: To describe primary biliary cholangitis epidemiology and investigate treatment patterns for Italian patients with this disease. Read More

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http://dx.doi.org/10.1016/j.dld.2018.11.008DOI Listing
November 2018
7 Reads

Diagnostic yield of upper endoscopy according to appropriateness: A systematic review.

Dig Liver Dis 2018 Dec 10. Epub 2018 Dec 10.

Internal Medicine and Gastroenterology, Department of Surgical and Medical Sciences, University of Bologna, Bologna, Italy.

Background/aim: Despite some official guidelines are available, a substantial rate of inappropriateness for upper gastrointestinal (UGI) endoscopies has been reported. This study aimed to estimate the inappropriate rate of UGI in different countries, also including the diagnostic yield.

Methods: A systematic review of studies on UGI endoscopy appropriateness was performed by adopting official guidelines as reference standard. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15908658183126
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http://dx.doi.org/10.1016/j.dld.2018.11.029DOI Listing
December 2018
12 Reads

A study of the association between UGT1A1*28 variant allele of UGT1A1 gene and colonic phenotype of sporadic colorectal cancer.

Dig Liver Dis 2018 Dec 10. Epub 2018 Dec 10.

Department of Hepatogastroenterology and Digestive Oncology, Tours, France; EA 7501 (GICC), Université de Tours, France.

Introduction: The transcriptional activity of the UGT1A1 gene is modulated by a variable number of repetitions of the dinucleotide (TA) within its promoter region. By comparison to the most common allele (TA) (UGT1A1*1), decreased activity is observed with increasing TA repetitions. The aim of this study was to determine whether the presence of the variant allele UGT1A1*28, harbouring seven TA repetitions, (TA), in the homozygous state, is associated with precancerous colonic lesions and/or with specific colorectal cancer characteristics. Read More

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http://dx.doi.org/10.1016/j.dld.2018.11.032DOI Listing
December 2018
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Predictors of early recurrence after strictureplasty for Crohn's disease of the small bowel during the years of biologics.

Dig Liver Dis 2018 Dec 8. Epub 2018 Dec 8.

Surgery of the Alimentary Tract, Department of Medical and Surgical Sciences, Sant'Orsola - Malpighi Hospital, Alma Mater Studiorum University of Bologna, Bologna, Italy.

Background: The identification of patients prone to early recurrence of Crohn's disease at the site of a strictureplasty is fundamental in the clinical practice.

Aims: Aim of the study is to detect the risk factors for early reoperation for recurrence after primary strictureplasty.

Methods: From 2000, patients undergoing a primary strictureplasty and a subsequent reoperation for recurrence of Crohn's disease at the site of a strictureplasty were included. Read More

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http://dx.doi.org/10.1016/j.dld.2018.11.027DOI Listing
December 2018
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Coronary flow reserve is an innovative tool for the early detection of cardiovascular dysfunction in primary biliary cholangitis patients.

Dig Liver Dis 2018 Nov 29. Epub 2018 Nov 29.

Department of Biomedical Sciences, Humanitas University, Milan, Italy; Internal Medicine and Hepatology Unit, Humanitas Clinical and Research Center, IRCCS, Rozzano (MI), Italy. Electronic address:

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http://dx.doi.org/10.1016/j.dld.2018.11.017DOI Listing
November 2018
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Modified FOLFIRINOX versus CisGem first-line chemotherapy for locally advanced non resectable or metastatic biliary tract cancer (AMEBICA)-PRODIGE 38: Study protocol for a randomized controlled multicenter phase II/III study.

Dig Liver Dis 2019 Feb 28;51(2):318-320. Epub 2018 Nov 28.

Hôpital privé Jean Mermoz, Lyon, France.

Introduction: Combination of cisplatine and Gemcitabine (CisGem) is the reference 1st line Chemotherapy in patients with advanced biliary cancer. FOLFIRINOX demonstrated an overall survival superiority when compared to gemcitabine in 1st line for patients with metastatic pancreatic adenocarcinoma. Because of similarities between pancreatic and biliary cancers, we proposed a randomized trial comparing mFOLFIRINOX and CisGEm. Read More

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http://dx.doi.org/10.1016/j.dld.2018.11.018DOI Listing
February 2019
2 Reads