1,344,262 results match your criteria Digestive Surgery[Journal]


In vitro digestion under simulated saliva, gastric and small intestinal conditions and fermentation by human gut microbiota of polysaccharides from the fruits of Lycium barbarum.

Int J Biol Macromol 2018 Dec 12. Epub 2018 Dec 12.

National Wolfberry Engineering Research Center, Yinchuan 750002, People's Republic of China. Electronic address:

In the present study, the digestion under simulated saliva, gastric and small intestinal conditions and in vitro fermentation by human gut microbiota of Lycium barbarum polysaccharides (LBPS) were investigated. As a result, LBPS contained carbohydrates, uronic acids, protein and polyphenols of 60.96 ± 5. Read More

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December 2018

Gallstone formation as an example of the two-step space confined aggregation process.

Authors:
Jacek Siódmiak

Biosystems 2018 Dec 12. Epub 2018 Dec 12.

Institute of Mathematics and Physics, UTP University of Science and Technology, Al. Prof. S. Kaliskiego 7, 85-796 Bydgoszcz, Poland. Electronic address:

Gallstone disease and in particular its cholesterol type is one of the most common diseases of the digestive system. More than 10% of the population is affected by this disease and in the case of Native Indians of Peru and Chile this rate reaches as much as 100%. While the disease is well-researched from a medical point of view, the two-step mechanism of formation of gallstones is not well studied. Read More

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December 2018

Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide.

Gastroenterology 2018 Dec 12. Epub 2018 Dec 12.

Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine - DIMED, University of Padova, Padova, Italy. Electronic address:

Background And Aims: Bacterial infections are common and life-threatening in patients with cirrhosis. Little is known about the epidemiology of bacterial infections in different regions. We performed a multicenter prospective intercontinental study to assess the prevalence and outcomes of bacterial and fungal infections in patients with cirrhosis. Read More

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December 2018

A new mucin-binding lectin from the marine sponge Aplysina fulva (AFL) exhibits antibiofilm effects.

Arch Biochem Biophys 2018 Dec 12. Epub 2018 Dec 12.

Laboratório de Biotecnologia Marinha - BioMar-Lab, Departamento de Engenharia de Pesca, Universidade Federal do Ceará, Campus do Pici s/n, bloco 871, 60440-970, Fortaleza, Ceará, Brazil. Electronic address:

A new mucin-binding lectin (AFL) was isolated from the marine sponge Aplysina fulva. AFL was purified by affinity chromatography on Sepharose™ matrix. Its hemagglutinating activity was independent of divalent ions, and it was weakly inhibited by simple sugars. Read More

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December 2018

Extracorporeal shock wave lithotripsy is safe and effective for geriatric patients with chronic pancreatitis.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology, The Second Military Medical University, Shanghai, China.

Background & Aims: Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is first-line treatment for chronic pancreatitis (CP) patients with pancreatic stones. However, the performance of P-EWSL in geriatric patients remains unclear. We aimed to evaluate the safety and efficacy of P-ESWL for them. Read More

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December 2018

Microwave-Assisted Digestion Procedures Using Diluted Oxidant Mixture for Elemental Analysis of Crustaceans by MIP OES.

Biol Trace Elem Res 2018 Dec 14. Epub 2018 Dec 14.

Group of Analytical Spectrometry Applied, Faculty of Chemistry, Federal University of Pará, Belém, Pará, 66075-110, Brazil.

The aim of this study was to evaluate three digestion procedures using a diluted oxidant mixture of nitric acid, hydrogen peroxide, and water for determination of Cu, Fe, K, Mg, Mn, and Zn in shrimp and crab samples from Northern Brazil by microwave-induced plasma optical emission spectrometry. The efficiency of the digestion procedure was evaluated by comparing the residual carbon content, residual acidity, and elemental concentrations obtained in the samples. Digestion procedure 2 (4 mL HNO + 4 mL HO + 4 mL HO) was chosen due the adequate residual carbon content (5. Read More

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December 2018

Out-of-home informal support important for medication adherence, diabetes distress, hemoglobin A1c among adults with type 2 diabetes.

J Behav Med 2018 Dec 14. Epub 2018 Dec 14.

Department of Family Medicine, University of Michigan, Ann Arbor, MI, USA.

Adults with type 2 diabetes mellitus (T2DM) often receive self-management support from adult children, siblings or close friends residing outside of their home. However, the role of out-of-home support in patients' self-management and well-being is unclear. Patients (N = 313) with HbA1c > 7. Read More

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December 2018

Heller myotomy is the optimal index procedure for esophageal achalasia in adolescents and young adults.

Surg Endosc 2018 Dec 14. Epub 2018 Dec 14.

Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.

Background: There is limited and conflicting data on the optimal intervention for the treatment of achalasia in adolescents and young adults (AYA), Heller myotomy (HM), esophageal dilation (ED) or botulinum toxin injection (botox). The goal of this study is to determine the most appropriate index intervention for achalasia in the AYA population.

Methods: We completed a longitudinal, population-based analysis of the California (2005-2010) and New York (1999-2014) statewide databases. Read More

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December 2018

Isolation of Biopsy-Derived, Human Cervical Keratinocytes Propagated as Monolayer and Organoid Cultures.

Sci Rep 2018 Dec 14;8(1):17869. Epub 2018 Dec 14.

Department of Biology, Lakehead University, Thunder Bay ON, P7B 5E1, Canada.

The successful isolation and propagation of patient-derived keratinocytes from cervical lesions constitute a more appropriate model of cervical disease than traditional cervical cancer-derived cell lines such as SiHa and CaSki. Our aim was to streamline the growth of patient-obtained, cervical keratinocytes into a reproducible process. We performed an observational case series study with 60 women referred to colposcopy for a diagnostic biopsy. Read More

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December 2018

Connectivity of the Superficial Muscles of the Human Perineum: A Diffusion Tensor Imaging-Based Global Tractography Study.

Sci Rep 2018 Dec 14;8(1):17867. Epub 2018 Dec 14.

Department of Bioengineering, Medicine & Radiology, University of California, San Diego, CA, USA.

Despite the importance of pelvic floor muscles, significant controversy still exists about the true structural details of these muscles. We provide an objective analysis of the architecture and orientation of the superficial muscles of the perineum using a novel approach. Magnetic Resonance Diffusion Tensor Images (MR-DTI) were acquired in 10 healthy asymptomatic nulliparous women, and 4 healthy males. Read More

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December 2018

Sphingoid bases of dietary ceramide 2-aminoethylphosphonate, a marine sphingolipid, absorb into lymph in rats.

J Lipid Res 2018 Dec 14. Epub 2018 Dec 14.

Kyoto University, Japan;

Various functions of dietary sphingolipids have been reported; however, little is known about marine sphingolipids. Ceramide 2-aminoethylphosphonate (CAEP), an abundant sphingolipid in marine molluscs, frequently has a unique triene-type of sphingoid base (2-amino-9-methyl-4,8,10-octadecatriene-1,3-diol, or d19:3). We previously reported that dietary CAEP prepared from the skin of squid was digested in the intestinal mucosa of mice via ceramides to yield free sphingoid bases. Read More

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December 2018

Direct-Acting Antivirals in Hepatitis C Virus-Associated Diffuse Large B-cell Lymphomas.

Oncologist 2018 Dec 14. Epub 2018 Dec 14.

Department of Molecular Medicine, University of Pavia, Pavia, Italy.

Background: International guidelines suggest hepatitis C virus (HCV) eradication by direct-acting antivirals (DAAs) after first-line immunochemotherapy (I-CT) in patients with HCV-positive diffuse large B-cell lymphoma (DLBCL), although limited experiences substantiate this recommendation. Moreover, only a few data concerning concurrent administration of DAAs with I-CT have been reported.

Subjects, Materials, And Methods: We analyzed hematological and virological outcome and survival of 47 consecutive patients with HCV-positive DLBCL treated at 23 Italian and French centers with DAAs either concurrently (concurrent cohort []: = 9) or subsequently (sequential cohort []: = 38) to first-line I-CT (mainly rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone [R-CHOP]-like). Read More

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December 2018

Cortical networks are disturbed in people with cirrhosis even in the absence of neuropsychometric impairment.

Clin Neurophysiol 2018 Nov 26. Epub 2018 Nov 26.

UCL Institute for Liver & Digestive Health, Division of Medicine, Royal Free Campus, University College London, Hampstead, London, UK. Electronic address:

Objective: Hepatic encephalopathy is a common complication of cirrhosis; it is characterised by neuropsychometric/neurophysiological abnormalities. Its pathophysiology is complex but glial neuronal communication is likely to be disrupted and to impact on oscillatory networks and cortical connectivity. The aim of this study was to use multichannel electroencephalography (EEG) to investigate functional connectivity, as a surrogate for cortical networks, in patients with cirrhosis. Read More

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November 2018

Bifidobacterium xylocopae sp. nov. and Bifidobacterium aemilianum sp. nov., from the carpenter bee (Xylocopa violacea) digestive tract.

Syst Appl Microbiol 2018 Nov 29. Epub 2018 Nov 29.

Dipartimento di Scienze e Tecnologie Agro-Alimentari, University of Bologna, Viale Fanin 44, 40127, Bologna, Italy.

Social bees harbor a community of gut mutualistic bacteria, among which bifidobacteria occupy an important niche. Recently, four novel species have been isolated from guts of different bumblebees, thus allowing to suppose that a core bifidobacterial population may be present in wild solitary bees. To date there is sparse information about bifidobacteria in solitary bees such as Xylocopa and Osmia spp. Read More

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November 2018

[Constitutional MMR deficiency: Genetic bases and clinical implications].

Bull Cancer 2018 Dec 11. Epub 2018 Dec 11.

Paris Sciences Lettres Research University, institut Curie, département de génétique, 75005 Paris, France; Sorbonne Universités, UPMC université Paris 06, Centre de recherche Saint-Antoine, Inserm, CNRS, 75012 Paris, France. Electronic address:

Inherited mono-allelic mutation in one of the 4 major MMR genes results in Lynch syndrome which predisposes, in adulthood, mainly to colorectal and endometrial tumors characterized by microsatellite instability (MSI phenotype). Individuals with bi-allelic mutations of one of these genes developed early and multiple malignancies, most often in childhood. This recessively inherited condition is named CMMRD for Constitutional Mismatch Repair Deficiency. Read More

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December 2018

Composition and functional roles of the gut microbiota in mosquitoes.

Authors:
Michael R Strand

Curr Opin Insect Sci 2018 Aug 22;28:59-65. Epub 2018 May 22.

Department of Entomology, University of Georgia, Athens, GA 30602, United States of America. Electronic address:

An estimated 3500 species of mosquitoes (family Culicidae) exist worldwide of which several are known vectors of pathogens that cause disease in humans and other vertebrates. Mosquitoes also host communities of microbes in their digestive tract that form a gut microbiota. Recent studies provide important insights on how mosquitoes acquire a gut microbiota and the community of microbes that are present. Read More

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Transmission of mutualistic bacteria in social and gregarious insects.

Curr Opin Insect Sci 2018 Aug 14;28:50-58. Epub 2018 May 14.

Department of Evolutionary Ecology, Institute of Organismic and Molecular Evolution, Johannes Gutenberg-University Mainz, Johann-Joachim-Becher-Weg 13, 55128 Mainz, Germany. Electronic address:

Symbiotic microbes can confer a range of benefits to social, sub-social, and gregarious insects that include contributions to nutrition, digestion, and defense. Transmission of beneficial symbionts to the next generation in these insects sometimes occurs transovarially as in many solitary insects, but primarily through social contact such as coprophagy in gregarious taxa, and trophallaxis in eusocial insects. While these behaviors benefit reliable transmission of multi-microbial assemblages, they may also come at the cost of inviting the spread of parasites and pathogens. Read More

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Pancreatic carcinoma underlying a complex presentation in late pregnancy: a case report.

J Med Case Rep 2018 Dec 15;12(1):369. Epub 2018 Dec 15.

Department of Maternal-Fetal Medicine Pregnancy Research Centre, Royal Women's Hospital, Parkville, Australia.

Background: Gestational diabetes mellitus is strongly related to the risk of pancreatic cancer in pregnant women, but gestational diabetes can precede a diagnosis of pancreatic cancer by many years. Women with a history of gestational diabetes showed a relative risk of pancreatic cancer of 7.1. Read More

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December 2018

Piperlongumine, a piper alkaloid targets Ras/PI3K/Akt/mTOR signaling axis to inhibit tumor cell growth and proliferation in DMH/DSS induced experimental colon cancer.

Biomed Pharmacother 2019 Jan 13;109:1462-1477. Epub 2018 Nov 13.

Department of Biochemistry Basic Medical Science Block-II Sector-25, South Campus, Panjab University, Chandigarh 160014, India. Electronic address:

Colorectal cancer (CRC) is the most common carcinoma of the digestive tract. The slow growing nature of CRC offers a great opportunity for prevention strategies. The concept of chemoprevention of colorectal cancer using plant derived natural products is gaining substantial attention because it is an inherently safe and cost-effective alternative to conventional cancer therapies. Read More

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January 2019

Chemopreventive and Anticancer Activities of Bacopa monnieri Extracted from Artificial Digestive Juices.

Nat Prod Commun 2017 Mar;12(3):337-342

Bacopa monnieri (L.) Pennell (water hyssop) from the Scrophulariaceae family represents one of the best known plants of the Ayurveda system, with reported precognitive, antioxidant, anti-inflammatory, neuroprotective, and anticonvulsant activity. It is considered to be a central nervous system modulating agent. Read More

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Work Loss Before and After Diagnosis of Crohn's Disease.

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.

Background: The aim of this study was to examine work loss in patients with Crohn's disease.

Methods: Using nationwide registers, we identified incident patients with Crohn's disease (2007-2010) and population comparator subjects without inflammatory bowel disease, matched by age, sex, calendar year, health care region, and education level. We assessed the number of lost workdays due to sick leave and disability pension from 5 years before to 5 years after first diagnosis of Crohn's disease or end of follow-up (September 30, 2015). Read More

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December 2018
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Cadmium bioaccumulation and elimination in tissues of the freshwater mussel Anodonta woodiana.

Chemosphere 2018 Dec 6;219:321-327. Epub 2018 Dec 6.

School of Life Science, Shanxi University, Taiyuan, Shanxi, 030006, China. Electronic address:

Experiments were carried out to investigate the bioaccumulation and elimination of cadmium (Cd) in tissues (kidney, gills, digestive gland, mantle, visceral mass, foot, adductor muscle and hemolymph) from the freshwater mussel, Anodonta woodiana. The mussels were exposed to subchronic Cd at concentrations of 0.168 and 0. Read More

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December 2018

Valorization of microalgal biomass by hydrothermal carbonization and anaerobic digestion.

Bioresour Technol 2018 Dec 4;274:395-402. Epub 2018 Dec 4.

Chemical Engineering Department, Universidad Autonoma de Madrid, Campus de Cantoblanco, 28049 Madrid, Spain. Electronic address:

The potential of hydrothermal carbonization (HTC) as a novel choice for treating microalgal biomass (MAB) was assessed. The hydrochar obtained at 210 °C had a carbon content and a higher heating value (HHV) 1.09 and 1. Read More

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December 2018

How I Do it: Flexible 3D endoscope for Endoscopic Submucosal Dissection.

Dig Endosc 2018 Dec 14. Epub 2018 Dec 14.

Division of Upper GI and Metabolic Surgery, Department of Surgery, Institute of Digestive Disease.

Endoscopic submucosal dissection (ESD) is technically challenging due to lack of depth perception. This report investigated effect of 3D endoscope for ESD and translate the technique from bench to clinical. In preclinical porcine experiment, the performance of ESD using 3D endoscope was compared between experienced and novice endoscopist. Read More

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December 2018
1 Read

Alcohol and gastrointestinal cancers.

Curr Opin Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Pancreato-Biliary Endoscopy Division and Endosonography Division, Pancreas Translational and Clinical Research Centre, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan.

Purpose Of Review: Alcohol is a type I carcinogen and the WHO stated that it caused 5% of all deaths in 2016, of which 13% because of cancers. Among digestive tract cancers, this association is clear for esophageal, liver and colorectal cancer, and more debated for gastric and pancreatic cancer. The present review will revise recent evidence on epidemiologic association and mechanisms linking alcohol with the risk of esophageal, gastric, colorectal and pancreatic cancers. Read More

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December 2018

Intraductal papillary neoplasm of the bile duct (IPNB): a rare precursor of cholangiocarcinoma.

Liver Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium.

Laboratory tests in an asymptomatic 70-year-old Caucasian man revealed biological cholestasis with an increased level of γ-GT. Abdominal tomography showed a mass in the left hepatic lobe, nearly four centimeters in diameter and associated with a dilated left bile duct. PET imaging revealed high glucose uptake. Read More

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December 2018
1 Read

Cold snare polypectomy: indications, devices, techniques, outcomes and future.

Dig Endosc 2018 Dec 14. Epub 2018 Dec 14.

Digestive Disease Center, Showa Inan General Hospital, Komagane, Japan.

Colonoscopy has been shown to reduce the risk of colon cancer by enabling the removal of precancerous lesions. Although the cold snare and hot snare polypectomy have similar retrieval rates and complete resection rates, the rates of delayed bleeding tend to be lower with cold snare polypectomy than with hot snare polypectomy, especially for patients taking antithrombotic agents. However, among cold snares there may be differences in terms of the completeness of polyp excision, as complete removal appears more likely with thin-wire dedicated cold snares compared to the traditional, thick-wire cold snares. Read More

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December 2018

Artificial intelligence and upper gastrointestinal endoscopy: current status and future perspective.

Dig Endosc 2018 Dec 14. Epub 2018 Dec 14.

Graduate School of Informatics, Nagoya University, Nagoya, Japan.

With recent breakthroughs in artificial intelligence, computer-aided diagnosis (CAD) for upper gastrointestinal endoscopy is gaining increasing attention. Main research focuses in this field include automated identification of dysplasia in Barrett's esophagus and detection of early gastric cancers. By helping endoscopists avoid missing and mischaracterizing neoplastic change in both the esophagus and stomach, these technologies potentially contribute to solving current limitations of gastroscopy. Read More

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December 2018

Recurrence of hereditary hemorrhagic telangiectasia after liver transplantation: clinical implications and physiopathological insights.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

Gustave Roussy Cancer Campus, Département de Biologie et Pathologie Médicales, Service de Pathologie Moléculaire, Villejuif.

Liver transplantation (LT) has been proposed as a curative treatment in hereditary hemorrhagic telangiectasia (HHT) with severe hepatic involvement. We provide a long-term evaluation of graft status after LT for HHT, with a focus on the risk of recurrence. The present study included all patients prospectively followed-up after LT for HHT in the Lyon liver transplant unit from 1993 to 2010, with a survival of more than 1 year. Read More

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December 2018

Entecavir and peginterferon alfa-2a in adults with HBeAg-positive immune tolerant chronic hepatitis B virus infection.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

University of Michigan.

Background/aim: Monotherapy with interferon or nucleoside analog is generally not recommended during the immune tolerant (IT) phase of chronic hepatitis B virus (HBV) infection. Recognition that high HBV DNA levels are associated with hepatocellular carcinoma has increased interest in treating HBV in the IT phase. Small pediatric studies reported efficacy with combination nucleoside analog and interferon therapy. Read More

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December 2018

Indocyanine green-enhanced fluorescence-guided video-assisted axillary surgery for chronic lymphocele.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Surgical Oncology, Unit of Surgical Oncology of the Esophagus and Digestive Tract, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.

Introduction: Lymphocele occurs frequently after regional lymph node dissection. Surgery with multiple lymphatic ligation represents the only reliable treatment for long-standing chronic lymphocele.

Materials And Surgical Technique: We report the case of a man with chronic axillary seroma after axillary lymphadenectomy for melanoma. Read More

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December 2018
1 Read

Multiple psychological factors predict abdominal pain severity in children with irritable bowel syndrome.

Neurogastroenterol Motil 2018 Dec 13:e13509. Epub 2018 Dec 13.

Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Background: Anxiety and depression are implicated as contributors to abdominal pain in pediatric irritable bowel syndrome (IBS) but is unclear if this pain is associated with other psychological factors. The study objective was to test if the impact of anxiety or depression on IBS symptom severity is mediated by somatization and/or pain catastrophizing.

Methods: We utilized baseline data from local pediatric IBS clinical studies. Read More

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December 2018

Subtyping of intraductal papillary mucinous neoplasms - pitfalls of MUC1 immunohistochemistry.

APMIS 2019 Jan 22;127(1):27-32. Epub 2018 Nov 22.

Department of Pathology, Copenhagen University Hospital Rigshospitalet, København, Denmark.

Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic ductal adenocarcinoma (PDAC). Current edition of WHO Classification of Tumors of the Digestive System recognizes four different subtypes (gastric, intestinal, pancreatobiliary, and oncocytic) and recommends analysis of mucin expression (MUC1, MUC2, MUC5AC, MUC6) as well as evaluation of architectural and cell differentiation patterns for correct classification. However, there is no consensus on MUC1 expression of IPMN-lesions in the literature. Read More

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January 2019

Simultaneous Robotic Total Mesorectal Excision and Radical Prostatectomy and Enlarged Iliac Lymphadenectomy for Synchronous Adenocarcinomas - a Video Vignette.

Colorectal Dis 2018 Dec 13. Epub 2018 Dec 13.

Unit of Digestive of Digestive Surgery, Henri Mondor Hospital, AP-HP, University of Paris Est, UPEC, Créteil, France.

Synchronous, locally-advanced, low rectal cancer and prostate adenocarcinoma together represent a rare and challenging situation for both colorectal surgeons and urologists. The simultaneous resection of both adenocarcinomas after long-course chemoradiation therapy may be associated with a potentially increased postoperative morbidity [1, 2]. On the other hand, simultaneous resection minimises the complications which might be expected if the two procedures are scheduled sequentially. Read More

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December 2018

Associated anomalies in cases with anorectal anomalies.

Am J Med Genet A 2018 Dec 12:e40530. Epub 2018 Dec 12.

Laboratoire de Génétique Médicale, Faculté de Médecine, Université de Strasbourg, Strasbourg cedex, France.

Anorectal anomalies (ARA) are common congenital anomalies. The etiology of ARA is unclear and its pathogenesis is controversial. Cases with ARA often have other non-ARA-associated congenital anomalies. Read More

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December 2018

Enzymatic Assisted Development of Biofunctional Polyphenol-enriched Buckwheat Protein: Physicochemical Property, In Vitro Digestibility and Antioxidant Activity.

J Sci Food Agric 2018 Dec 12. Epub 2018 Dec 12.

Food Protein Research and Development Center, Department of Food Science and Engineering, South China University of Technology, Guangzhou, 510640, PR China.

Background: During the last decade, buckwheat is reported to have biological activities and functional properties. The present study investigated the high-polyphenol buckwheat (Fagopyrum esculentum Moench) protein prepared by dual-enzymatic hydrolysis assisting and its physicochemical property, in vitro digestibility and antioxidant activity.

Results: Results showed that the polyphenols of the buckwheat protein (E-BWP) from a synergistic enzymatic action of 1. Read More

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December 2018

Microbes: possible link between modern lifestyle transition and the rise of metabolic syndrome.

Obes Rev 2018 Dec 11. Epub 2018 Dec 11.

Department of Internal Medicine, Division of Gastroenterology, Rush University Medical Center, Chicago, IL, USA.

The rapid decrease in infectious diseases globally has coincided with an increase in the prevalence of obesity and other components of metabolic syndrome. Insulin resistance is a common feature of metabolic syndrome and can be influenced by genetic and non-genetic/environmental factors. The emergence of metabolic syndrome epidemics over only a few decades suggests a more prominent role of the latter. Read More

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December 2018

Atypical actinobacillosis affecting hind limbs and lungs in a single beef cattle herd.

J Vet Intern Med 2018 Dec 12. Epub 2018 Dec 12.

Clinic for Ruminants, Nantes, France.

Actinobacillosis usually is a sporadic infection that affects the tongue in cattle ("wooden tongue") with possible spread to the digestive tract. Two 4-year-old Rouge-des-Prés cows from a single French beef herd were referred for chronic (2-6 months) swelling and cutaneous nodules in the distal hind limbs. In addition to cutaneous signs, physical examination disclosed cachexia, lameness, lymphadenitis of the hind limbs, and pneumonia in both cows. Read More

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December 2018
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TNF, but not hyperinsulinemia or hyperglycemia, is a key driver of obesity-induced monocytosis revealing that inflammatory monocytes correlate with insulin in obese male mice.

Physiol Rep 2018 Dec;6(23):e13937

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.

Inflammation contributes to obesity-related hyperinsulinemia and insulin resistance, which often precede type 2 diabetes. Inflammation is one way that obesity can promote insulin resistance. It is not clear if the extent of obesity, hyperinsulinemia, or hyperglycemia, underpins changes in cellular immunity during diet-induced obesity. Read More

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December 2018

Apelinergic system in the kidney: implications for diabetic kidney disease.

Physiol Rep 2018 Dec;6(23):e13939

Department of Medicine, Division of Nephrology and Hypertension, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

The bioactive peptides of the apelinergic system and its receptor APJ have been shown to play a protective role in experimental cardiovascular and diabetic kidney disease (DKD). Mechanisms of this renoprotective effect remain to be elucidated. In this study, we examined the localization of APJ within the normal kidney and its kidney expression in the db/db model of DKD. Read More

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December 2018
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Introduction to Themed Series on Intestinal Stem Cells and the NIDDK Intestinal Stem Cell Consortium.

Am J Physiol Gastrointest Liver Physiol 2018 Dec 14. Epub 2018 Dec 14.

University of California at San Francisco, United States.

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December 2018

Endoscopic submucosal dissection followed by chemoradiotherapy for superficial esophageal cancer: choice of new approach.

Radiat Oncol 2018 Dec 14;13(1):246. Epub 2018 Dec 14.

Department of Radiology, Kyoto Prefectural University Graduate School of Medical Science, 465 Kajiicho Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Background: The standard treatment for superficial esophageal cancer (SEC) involving muscularis mucosal (T1a-MM) or submucosal (T1b) invasion has been the surgical resection of the esophagus. However, esophagectomy with extended lymph node dissection is highly invasive. Recent reports have shown that endoscopic submucosal dissection (ESD) followed by chemoradiotherapy (CRT) has promising results and might become a new therapeutic approach. Read More

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December 2018

Timing of Palliative Care Consultation and the Impact on Thirty-Day Readmissions and Inpatient Mortality.

J Palliat Med 2018 Dec 14. Epub 2018 Dec 14.

5 Jersey City, New Jersey.

Background: Inpatient palliative care consultation (PCC) may reduce 30-day readmissions and inpatient mortality among seriously ill patients.

Objective: To evaluate the impact of timing of PCC on 30-day readmissions and inpatient mortality.

Design: Retrospective, observational study comparing risk-adjusted, observed-to-expected (O/E) 30-day readmissions and inpatient mortality among patients receiving inpatient PCC to all other inpatients. Read More

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December 2018

Heavy Metals and Polycyclic Aromatic Hydrocarbons in Soil from E-waste Dumpsites in Lagos and Ibadan, Nigeria.

J Health Pollut 2017 Sep 7;7(15):71-84. Epub 2017 Sep 7.

Department of Chemistry, University of Ibadan, Ibadan, Nigeria.

Background: Soil contamination from heavy metals and polycyclic aromatic hydrocarbons (PAHs) released during informal e-waste processing and disposal poses human and ecological health risks in Nigeria.

Objectives: This study assesses the levels of heavy metals and PAHs in soils of e-waste dumpsites in Lagos and Ibadan, Nigeria.

Methods: Composite soil samples were collected at depths of 0-15 cm, 15-30 cm and 30-45 cm from major e-waste dumpsites in Lagos and Ibadan and analyzed for lead (Pb), cadmium (Cd), copper (Cu), nickel (Ni), zinc (Zn), chromium (Cr) and PAHs to evaluate the potential contaminant contribution from e-waste activities. Read More

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September 2017

Distribution of Fluoride in the Phosphorite Mining Area of Hahotoe-Kpogame (Togo).

J Health Pollut 2016 Jun 16;6(10):84-94. Epub 2016 Jun 16.

Management, Treatment and Promotion of Wastes Laboratory; Faculty of Science, University of Lomé, Togo.

Background: Phosphorites in the mining area of Hahotoé-Kpogamé contain high levels of fluoride that can cause illness among people living close to the mining and processing sites.

Objectives: To assess the distribution of fluoride in the different areas around the phosphorite mining areas in Togo.

Methods: Analyses were performed by molecular absorption spectrometer (HACH DR3800) according to the procedure manual at the geochemical laboratory of the University of Lomé. Read More

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Evaluation of Pulmonary Toxicity of Nanoparticles by Bronchoalveolar Lavage.

Methods Mol Biol 2019 ;1894:313-322

Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA.

Nanoparticles can enter the body via the lungs, the digestive tract, and the skin. The pulmonary effects of nanoparticles and the underlying mechanisms may be investigated by histopathological examination, immunostaining, bronchoalveolar lavage (BAL), and so on. BAL is a simple, fast, and inexpensive method that is commonly used to investigate the immune cells and acellular components in the lungs, which reflect the health state of the lungs. Read More

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January 2019
5 Reads

Diagnosis using deep-learning artificial intelligence based on the endocytoscopic observation of the esophagus.

Esophagus 2018 Dec 13. Epub 2018 Dec 13.

AI Medical Service Inc., Tokyo, Japan.

Background And Aims: The endocytoscopic system (ECS) helps in virtual realization of histology and can aid in confirming histological diagnosis in vivo. We propose replacing biopsy-based histology for esophageal squamous cell carcinoma (ESCC) by using the ECS. We applied deep-learning artificial intelligence (AI) to analyse ECS images of the esophagus to determine whether AI can support endoscopists for the replacement of biopsy-based histology. Read More

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December 2018

Anaerobic treatment of residuals from tanks transporting food and fodder.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Faculty of Agricultural and Environmental Sciences, University of Rostock, Justus-von-Liebig-Weg 6, 18059, Rostock, Germany.

The anaerobic digestion of wastewater from the cleaning of tank cars transporting food and fodder was investigated in both bench and pilot scales with a single-stage, mesophilic (39 °C), completely mixed process. The promising results lead to the planning and building of a 1200-m full-scale biogas plant at TS-Clean cleaning station in Fahrbinde, Germany. Due to softened water used in the cleaning of the car tanks, the alkalinity in the digester decreased as predicted by the physicochemical model developed for this treatment process. Read More

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December 2018
1 Read

Primary hypophysitis and other autoimmune disorders of the sellar and suprasellar regions.

Rev Endocr Metab Disord 2018 Dec 13. Epub 2018 Dec 13.

Medicover GmbH, Berlin/Hannover, Germany.

The pituitary gland and the hypothalamus can be affected by autoimmune-mediated structural and functional disruption. These autoimmune-mediated diseases occur more commonly in females and are often found during pregnancy or in the post-partum period. Autoimmune diseases can either affect parts of the pituitary or hypothalamus, or can involve both sellar and suprasellar structures. Read More

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December 2018
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Laparoscopic Roux-En-Y Fistulo-Jejunostomy, a Preferred Technique after Failure of Endoscopic and Radiologic Management of Fistula Post Sleeve Gastrectomy.

Obes Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Digestive Surgery, Archet II Hospital, University of Nice-Sophia-Antipolis, 151 Route de Saint-Antoine, 06200, Nice, France.

Background: Laparoscopic sleeve gastrectomy represents the most performed bariatric procedure in France. Staple line leak is the major short-term complication of the procedure. Patients with persistent fistula after sleeve gastrectomy, after failure of endoscopic and radiological treatment, are candidates for salvage surgery. Read More

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December 2018
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