3,068 results match your criteria Digestive Diseases[Journal]


Chinese guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency (2018 Edition).

J Dig Dis 2019 Apr 21. Epub 2019 Apr 21.

Department of Gastroenterology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai, China.

Pancreatic exocrine insufficiency (PEI) is a condition characterized by insufficient or unsynchronized secretion of pancreatic enzymes that results in maldigestion or malabsorption. The Chinese Study Group for Chronic Pancreatitis of the Chinese Medical Doctor Association gathered a group of experts on Gastroenterology, Biliary and Pancreatic Surgery, Radiology, Endocrinology, and Pathology to revise the Chinese Guidelines for the Diagnosis and Treatment of Pancreatic Exocrine Insufficiency (2012 Edition) based on the latest medical evidence both domestic and abroad. Read More

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http://dx.doi.org/10.1111/1751-2980.12753DOI Listing

Metastatic mixed acinar-neuroendocrine carcinoma of pancreas treated with multidisciplinary team: A case report and brief review of the literature.

J Dig Dis 2019 Apr 10. Epub 2019 Apr 10.

Department of Medical Oncology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.

Ranked the fourth or fifth most common cause of cancer globally, pancreatic cancer is recognized as "the king of cancer" for the high malignant potential (1). Pancreatic cancer develops from either the endocrine (islet cell) or exocrine (ductal or acinar cell) systems of the pancreas, and which can be categorized accordingly into three types: ductal, acinar or endocrine. Read More

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http://dx.doi.org/10.1111/1751-2980.12752DOI Listing
April 2019
1.924 Impact Factor

The Rationale and Efficacy of Primary and Secondary Prevention in Adenocarcinomas of the Upper Gastrointestinal Tract.

Dig Dis 2019 Apr 10:1-13. Epub 2019 Apr 10.

Department of Gastroenterology, Hepatology and Infectious Disease, Otto-von-Guericke University, Magdeburg, Germany.

While the primary risk factor for oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO) is gastro-oesophageal reflux, the infection with Helicobacter pylori (H. pylori) is the dominant risk factor for gastric cancer. Reduction of reflux by dietary measures and proton pump inhibitors has some merits in OAC prevention, and the chemopreventive effect of Aspirin and statins is being widely investigated; however, improved outcome in OAC occurs primarily as the result of secondary prevention. Read More

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http://dx.doi.org/10.1159/000499706DOI Listing
April 2019
1 Read

Safety and Efficacy of Fecal Microbiota Transplant in 9 Critically Ill Patients with Severe and Complicated Clostridium Difficile Infection with Impending Colectomy: A Case Series.

J Dig Dis 2019 Apr 10. Epub 2019 Apr 10.

Department of Gastroenterology, MedStar Georgetown University Hospital, Washington, DC, USA.

Background And Aims: There is significant data that support the efficacy and safety of Fecal Microbiota Transplant ( FMT) in Recurrent Clostridium Difficile Infection (RCDI). The objective of our study was to determine the success rate of FMT in patients diagnosed with severe and complicated CDI with impending colectomy in the ICU setting.

Methods: This was a 2 center study, which consisted of 9 patients who met criteria of severe and complicated CDI and had impending colectomy. Read More

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http://dx.doi.org/10.1111/1751-2980.12750DOI Listing
April 2019
1 Read

What are the main areas of focus to prevent or treat non-alcoholic fatty liver disease?

J Dig Dis 2019 Apr 10. Epub 2019 Apr 10.

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology, Research Institute Shahid Beheshti University of Medical Science, Tehran, Iran.

Recently, growing body of information has accumulated to suggest that nutritional status and food compounds impact on development and/or progression of non-alcoholic fatty liver disease (NAFLD). The most applicable strategy to prevent and treat NAFLD is diet and lifestyle modification through keeping healthy weight, following a well-balanced diet with appropriate energy intake and increasing physical activity and /or strength training. Here we review the literature and discuss existing and potential therapeutic strategies for prevention and management of NAFLD, emphasizing the description of nutritional status and its clinical impact on the outcomes of NAFLD. Read More

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http://dx.doi.org/10.1111/1751-2980.12751DOI Listing
April 2019
1 Read

[Pancreatic Mass or Cyst? Diagnostic Dilemma].

Dig Dis 2019 Apr 8:1-4. Epub 2019 Apr 8.

Division of Gastroenterology and Hepatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

A santorinicele is a rare anomaly defined as focal cystic dilation of the terminal portion of the dorsal pancreatic duct at the minor papilla. Importantly this anomaly has been suggested as a possible cause of relative stenosis of the minor papilla. This anomaly has been associated with pancreatic divisum and recurrent acute pancreatitis. Read More

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http://dx.doi.org/10.1159/000497448DOI Listing
April 2019
1 Read

The long non-coding RNAs exert regulatory roles in acetaminophen induced liver injury.

J Dig Dis 2019 Apr 5. Epub 2019 Apr 5.

Department of Liver Surgery and Liver Transplantation Center, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Aims: This study aimed to explore the expression profile and role of hepatic lncRNA in acetaminophen induced liver injury (AILI) mouse model using lncRNA-mRNA co-expression analysis.

Methods: Mice were sacrificed at different time points after APAP 300mg/kg treatment and serum aminotransferase, liver pathology and inflammatory cells were analyzed. High-throughput RNA sequencing was performed to investigate the liver expression profile of mRNA and lncRNA. Read More

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http://dx.doi.org/10.1111/1751-2980.12749DOI Listing

Pulley Traction-Assisted Colonic Endoscopic Submucosal Dissection: A Retrospective Case Series.

Dig Dis 2019 Apr 3:1-5. Epub 2019 Apr 3.

Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.

Background And Study Aims: We have reported the usefulness of traction-assisted colorectal endoscopic submucosal dissection (TAC-ESD) to overcome the technical difficulty of colorectal ESD. However, the direction of traction is toward the anal side only. We retrospectively evaluate the safety and efficacy of "pulley" TAC-ESD. Read More

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http://dx.doi.org/10.1159/000499670DOI Listing
April 2019
3 Reads

"Long-term efficacy and safety of Vedolizumab in Inflammatory Bowel Diseases patients: a real-life experience from a Tertiary Referral Center".

J Dig Dis 2019 Mar 30. Epub 2019 Mar 30.

IBD Referral Center, Gastroenterology Department, AOU Careggi Hospital, Florence, (Italy).

Aims: The aim of the study is to evaluate the long-term efficacy and safety of Vedolizumab in a real-life cohort of IBD patients enrolled at a tertiary referral center.

Methods: Data were retrospectively collected from August 2016 to November 2018. The primary outcomes rates were clinical response and remission at 14, 24 and 52 weeks, and steroid-free remission at 52 weeks. Read More

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http://dx.doi.org/10.1111/1751-2980.12748DOI Listing

Assessment of Duodenal Adenomas and Strategies for Curative Therapy.

Dig Dis 2019 Mar 28:1-7. Epub 2019 Mar 28.

Clinic for Gastroenterology and Hepatology, Clinical Center Serbia, Belgrade, Serbia.

Background: The increasing incidence of duodenal neoplasm has underlined different methods of resection depending on the clinical presentation, endoscopic features and histopathology. In this comprehensive review, we systematically describe the current knowledge concerning the diagnosis and management of duodenal adenomas (DAs) and discuss data considering all possible therapeutic approaches.

Summary: Among a variety of duodenal lesions, including neuroendocrine tumors and gastrointestinal stromal tumors, DAs present precancerous lesions of the duodenal papilla or non-ampullary region necessitating removal. Read More

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https://www.karger.com/Article/FullText/496697
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http://dx.doi.org/10.1159/000496697DOI Listing
March 2019
3 Reads
1.832 Impact Factor

Double open per-oral endoscopic myotomy(D-O-POEM) for the treatment of achalasia.

J Dig Dis 2019 Mar 27. Epub 2019 Mar 27.

Department of Gastroenterology, West China Hospital, Sichuan University, China, NO. 37, Guo Xue Xiang, Chengdu, Sichuan, China. 610041.

After the introduction of per-oral endoscopic myotomy(POEM) which was initially carried out in humans with achalasia by Inoue et al. in 2010, POEM has become an established treatment for achalasia due to its high feasibility and effectiveness. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/1751-2980.12723DOI Listing
March 2019
1 Read

Pancreatic Neuroendocrine Tumours: The Role of Endoscopic Ultrasound Biopsy in Diagnosis and Grading Based on the WHO 2017 Classification.

Dig Dis 2019 21;37(4):325-333. Epub 2019 Mar 21.

Humanitas Clinical and Research Center, IRCCS, Digestive Endoscopy Unit, Division of Gastroenterology, Milan, Italy.

Background: One of the controversial issues in the diagnosis of pancreatic neuroendocrine tumours (pNETs) is the accurate prediction of their clinical behaviour.

Objectives: The aim of the study was to evaluate the role of endoscopic ultrasound (EUS) biopsy in the diagnosis and grading of pNETs in a certified ENETS Center.

Methods: A prospectively maintained database of EUS biopsy procedures was retrospectively reviewed to identify all consecutive patients referred to a certified ENETS Center with a suspicion of pNET between June 2014 and April 2017. Read More

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http://dx.doi.org/10.1159/000499172DOI Listing
March 2019
2 Reads

Radiofrequency ablation is safe and effective in the treatment of Chinese patients with gastroesophageal reflux disease: A single-center prospective study.

J Dig Dis 2019 Mar 15. Epub 2019 Mar 15.

Digestive Endoscopy Center, Department of Gastroenterology, Changhai Hospital, Second Military Medical University (Naval Medical University), Shanghai, China.

Objective: This study aimed to evaluate the safety and efficiency of radiofrequency ablation (RFA) in Chinese patients with gastroesophageal reflux disease (GERD).

Methods: This was a single-center, prospective study including 27 Chinese patients with GERD. The outcomes in all patients were evaluated before and at 3, 6, and 12 months after RFA, including their GERD health-related quality of life (GERD-HRQL) score, esophageal acid exposure, DeMeester score, lower esophageal sphincter (LES) resting pressure, and patient's satisfaction with symptom control. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1751-2980.12
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http://dx.doi.org/10.1111/1751-2980.12722DOI Listing
March 2019
6 Reads

The utility of single operator cholangioscope (Spyglass) to diagnose and treat radiographically negative biliary stones: A case series and review.

J Dig Dis 2019 Mar 13. Epub 2019 Mar 13.

Department of Medicine, Division of Gastroenterology-Hepatology, Albany Medical College, Albany, New York, USA.

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http://doi.wiley.com/10.1111/1751-2980.12721
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http://dx.doi.org/10.1111/1751-2980.12721DOI Listing
March 2019
11 Reads

Gastrointestinal manifestations on impaired quality of life in systemic sclerosis.

J Dig Dis 2019 Mar 5. Epub 2019 Mar 5.

Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Objective: To analyze the impact of gastrointestinal manifestations on quality of life in patients with systemic sclerosis (SSc) and to provide clinical evidence for their early treatment and health-related management.

Methods: Altogether 65 patients admitted to the Peking Union Medical College Hospital selected from a disease cohort and 127 matched controls were enrolled. A self-assessment questionnaire was completed by all participants. Read More

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http://dx.doi.org/10.1111/1751-2980.12720DOI Listing

Bowel Preparation for Colonoscopy in Children: 1 Day PEG-3350 with Bisacodyl versus 3 Day Sennosides.

Dig Dis 2019 5;37(4):334-342. Epub 2019 Mar 5.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Marmara University School of Medicine, Istanbul, Turkey,

Background And Objectives: Bowel preparation (BP) for colonoscopy is a challenging procedure in children and different regimens have been used for this purpose. Polyethylene glycol (PEG) is the most preferred agent in recent years. The primary aim of this study was to evaluate the efficacy of 1-day PEG-3350 with bisacodyl (PEG-B) and comparing it with 3-day sennosides A+B. Read More

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http://dx.doi.org/10.1159/000497819DOI Listing
March 2019
2 Reads

Appropriate Management of Attenuated Familial Adenomatous Polyposis: Report of a Case and Review of the Literature.

Dig Dis 2019 Mar 5:1-6. Epub 2019 Mar 5.

Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Belgrade, Serbia,

Hereditary polyposis syndromes in which APC gene germline mutations can lead to colorectal carcinogenesis are familial adenomatous polyposis (FAP), attenuated FAP (AFAP) and MUTYH-associated polyposis. All 3 syndromes increase the potential for the development of colorectal cancer. AFAP is diagnosed if less than 100 adenomas are detected in the colon at presentation. Read More

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http://dx.doi.org/10.1159/000497207DOI Listing
March 2019
1 Read

The impact of endoscopic ultrasound in preoperative evaluation for ampullary adenomas.

J Dig Dis 2019 Mar 4. Epub 2019 Mar 4.

Department of Gastroenterology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China.

Objective: We aimed to evaluate the efficacy of endoscopic ultrasonography (EUS) in assessing locoregionally and determining therapeutic options for ampullary adenomas and the related factors.

Methods: Patients undergoing EUS and surgical or endoscopic resection for biopsy-proven ampullary adenomas between 2009 and 2016 were retrospectively analyzed. The depth of tumor invasion, intraductal extension, and regional lymph node staging evaluated by EUS were compared with post-treatment pathological findings. Read More

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http://dx.doi.org/10.1111/1751-2980.12719DOI Listing

Emerging next-generation robotic colonoscopy systems towards painless colonoscopy.

J Dig Dis 2019 Apr;20(4):196-205

Bio-Medical Engineering (HK) Limited, Hong Kong SAR, China.

Advances in the field of robotics have allowed modern technology to be integrated into medicine and that can minimize patients suffering from the side effects that are inherent to procedures for improving their quality of life. Conventional devices that are used for colonoscopies are rigid and require a high level of expertise from endoscopists to perform the procedure. Advances in robot-assisted colonoscopic systems now produce softer, more slender, automated designs that no longer require the operator to use forceful pushing to advance the colonoscope inside the colon, reducing risks to the patient of perforation and pain. Read More

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http://dx.doi.org/10.1111/1751-2980.12718DOI Listing
April 2019
5 Reads

Missense mutation in PRKCQ is associated with Crohn's disease.

J Dig Dis 2019 Mar 4. Epub 2019 Mar 4.

Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: Recent genome-wide association studies have demonstrated that rs2236379 in PRKCQ is a novel significant locus for Crohn's disease (CD). However, the association has not been replicated in any populations. We therefore aimed to investigate the prevalence of the PRKCQ rs2236379 variant in the Chinese Han population and evaluate whether the genetic variant of PRKCQ confers susceptibility to CD and is associated with its clinical characteristics. Read More

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http://dx.doi.org/10.1111/1751-2980.12717DOI Listing
March 2019
4 Reads

Mentality, Career, Mentorship: My Way.

Authors:
Zsolt Tulassay

Dig Dis 2019 21;37(4):263-265. Epub 2019 Feb 21.

Internal and Gastroenterological Clinic, Semmelweis University Budapest, Budapest, Hungary,

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http://dx.doi.org/10.1159/000497192DOI Listing
February 2019

Risk Factors for Low Bone Density in Inflammatory Bowel Disease: Use of Glucocorticoids, Low Body Mass Index, and Smoking.

Dig Dis 2019 21;37(4):284-290. Epub 2019 Feb 21.

Department of Endocrinology, Rambam Health Care Centre, Haifa, Israel.

Background: Inflammatory bowel disease (IBD) patients are reported to have lower bone density compared to healthy controls. There is limited consensus regarding factors affecting bone density among these patients. Our aim, therefore, was to determine clinical and genetic variables that contribute to lower bone mineral density (BMD) in IBD patients. Read More

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http://dx.doi.org/10.1159/000496935DOI Listing
February 2019
5 Reads

General Aspects of Primary Cancer Prevention.

Dig Dis 2019 Feb 15:1-10. Epub 2019 Feb 15.

Clinic for Gastroenterology and Hepatology, Clinical Canter of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.

Background: Cancer is the second leading cause of death worldwide next to cardiovascular diseases. Despite the advancement in screening, early diagnosis, and development in treatment technology in last several decades, cancer incidence overall, particularly that of gastrointestinal (GI) cancers, is far from being controlled, and is expected to increase worldwide.

Summary: Although numerous preclinical and population-based clinical studies have already made important progress in restraining the overall cancer incidence and mortality, the full potential of preventive strategy is still far from being realized, and remains at an early stage. Read More

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https://www.karger.com/Article/FullText/497191
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http://dx.doi.org/10.1159/000497191DOI Listing
February 2019
7 Reads
1.832 Impact Factor

Should Focal Nodular Hyperplasia Still be Operated Upon? Analysis of a Case Series.

Dig Dis 2019 14;37(4):309-314. Epub 2019 Feb 14.

Department of Integrated Medicine, Federal University of Rio Grande do Norte/University Hospital Onofre Lopes, Natal, Rio Grande do Norte, Brazil.

Background: Focal nodular hyperplasia (FNH) is a frequent benign liver lesion. Its course is considered benign, and there is no recommendation for its treatment. Nevertheless, the literature presents a high incidence of surgery. Read More

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http://dx.doi.org/10.1159/000496430DOI Listing
February 2019
1 Read

Endoscopic management of patients with early gastric cancer before and after endoscopic resection: A review.

J Dig Dis 2019 Feb 12. Epub 2019 Feb 12.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

With the wide application of endoscopic resection for early gastric cancer (EGC) by not only Asian endoscopists but also those from Western countries, reviews on standardized treatment processes before and after endoscopic resection are nevertheless lacking. In this article we provide a narrative review of studies on the selection of appropriate EGC for endoscopic resection and the follow-up strategies for those with histologically confirmed EGC after endoscopic resection. EGC should be comprehensively assessed before endoscopic resection, including its exact margin, invasive depth and risk of lymph node metastasis (LNM). Read More

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http://dx.doi.org/10.1111/1751-2980.12715DOI Listing
February 2019

Management of Bouveret's syndrome.

J Dig Dis 2019 Apr 28;20(4):215-219. Epub 2019 Mar 28.

Division of Transplant Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1111/1751-2980.12713DOI Listing
April 2019
2 Reads

Systematic review with meta-analysis: Chromoendoscopy versus white light endoscopy in detection of dysplasia in patients with inflammatory bowel disease.

J Dig Dis 2019 Apr 9;20(4):206-214. Epub 2019 Apr 9.

State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi Province, China.

Objective: To compare chromoendoscopy (CE) and white light endoscopy (WLE) for dysplasia surveillance in patients with inflammatory bowel disease (IBD).

Methods: We conducted a meta-analysis of 6 randomized controlled trials (RCTs) and 5 prospective studies and compared the CE and WLE groups. A fixed-effect model was used unless the heterogeneity was high. Read More

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http://dx.doi.org/10.1111/1751-2980.12714DOI Listing

Circulating miR-29b positively correlates with non-alcoholic fatty liver disease in a Chinese population.

J Dig Dis 2019 Apr 3;20(4):189-195. Epub 2019 Apr 3.

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Objective: Early screening of non-alcoholic fatty liver disease (NAFLD) is of great significance for the early detection and intervention in NAFLD. MicroRNAs (miRNAs) are important regulators of metabolic diseases including NAFLD. The aim of this study was to investigate the association of serum miR-29a-c with NAFLD in a Chinese population. Read More

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http://dx.doi.org/10.1111/1751-2980.12716DOI Listing
April 2019
2 Reads

Single-Dose Linaclotide Is Equal in Efficacy to Polyethylene Glycol for Bowel Preparation Prior to Capsule Endoscopy.

Dig Dis 2019 7;37(4):297-302. Epub 2019 Feb 7.

Motility Lab, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia, USA,

Background: Video capsule endoscopy provides noninvasive visualization of the small bowel, but yield is often limited by debris. At our institution, preparation with polyethylene glycol (PEG) and simethicone is used to improve visualization.

Aims: We hypothesized that linaclotide and simethicone would yield equal to better results. Read More

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https://www.karger.com/Article/FullText/496350
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http://dx.doi.org/10.1159/000496350DOI Listing
February 2019
8 Reads

Validation of Tokyo Guideline 2013 as Treatment of Acute Cholecystitis by Real World Data.

Dig Dis 2019 7;37(4):303-308. Epub 2019 Feb 7.

Department of Gastroenterology, Yamanashi Prefectural Central Hospital, Yamanashi, Japan.

Background: The Tokyo Guidelines (TG; 2013) indicated that emergency cholecystectomy is an important early treatment option for acute cholecystitis; however, surgical intervention is not necessarily indicated in patients with advanced age. We evaluated percutaneous transhepatic gallbladder aspiration (PTGBA), percutaneous transhepatic gallbladder drainage (PTGBD), and the administration of antibiotics alone as treatment options for acute -cholecystitis.

Methods: From January 2010 to December 2017, 159 patients with acute cholecystitis were treated at our institution. Read More

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http://dx.doi.org/10.1159/000496738DOI Listing
February 2019
2 Reads

Diabetes Mellitus and Age are Risk Factors of Interval Colon Cancer: A Case-Control Study.

Dig Dis 2019 7;37(4):291-296. Epub 2019 Feb 7.

Gastroenterology and Hepatology Institute, Meir Medical Center, Kfar Saba, Israel.

Background And Aims: Interval colorectal cancer (CRC) is largely related to a poor endoscopic performance or different biology in the development of the polyp. However, patient-related factors were less investigated for their association with interval cancer. We thus evaluated tumor and patient characteristics as predictors of interval cancer in a population from Israel. Read More

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http://dx.doi.org/10.1159/000496740DOI Listing
February 2019
1 Read

Unmet Medical Needs in Ulcerative Colitis: An Expert Group Consensus.

Dig Dis 2019 6;37(4):266-283. Epub 2019 Feb 6.

University Hospital Leuven, Leuven, Belgium,

Background: The authors aimed to conduct an extensive literature review and consensus meeting to identify unmet needs in ulcerative colitis (UC) and ways to overcome them. UC is a relapsing and remitting inflammatory bowel disease with varied, and changing, incidence rates worldwide. UC has an unpredictable disease course and is associated with a high health economic burden. Read More

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http://dx.doi.org/10.1159/000496739DOI Listing
February 2019
3 Reads
1.832 Impact Factor

Value of contrast-enhanced harmonic endoscopic ultrasonography in differentiating between gastrointestinal stromal tumors: A meta-analysis.

J Dig Dis 2019 Mar;20(3):127-134

Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Objective: Contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) is a valuable device to diagnose and determine the malignant potential of gastrointestinal stromal tumors (GIST) as early as possible when making clinical therapeutic decisions. This study aimed to estimate the ability of CH-EUS to discriminate between GIST and benign submucosal lesions (SML) and to predict their malignant potential.

Methods: PubMed, MEDLINE, EMBASE, the Web of Science, and Cochrane Central Register of Controlled Trials databases were screened. Read More

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http://dx.doi.org/10.1111/1751-2980.12710DOI Listing
March 2019
2 Reads

Quantitative immunochemical fecal occult blood test for neoplasia in colon cancer screening.

J Dig Dis 2019 Feb 10;20(2):78-82. Epub 2019 Mar 10.

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objective: To investigate the performance of the quantitative immunochemical fecal occult blood test (qFIT) and to determine the association between the fecal hemoglobin (Hb) level and the location and size of adenomas and the stages of colorectal cancer (CRC).

Methods: A total of 692 participants were included in the study. Their fecal Hb level was measured using an OC-SENSA MICRO qFIT. Read More

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http://dx.doi.org/10.1111/1751-2980.12711DOI Listing
February 2019
3 Reads

Fecal occult blood test in colorectal cancer screening.

J Dig Dis 2019 Feb 5;20(2):62-64. Epub 2019 Mar 5.

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Cancer screening is known to decrease mortality from CRC. One important test for CRC screening is the fecal occult blood test (FOBT), which includes guaiac FOBT and fecal immunological tests. Read More

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http://dx.doi.org/10.1111/1751-2980.12712DOI Listing
February 2019
5 Reads

Role of gut microbial metabolites in nonalcoholic fatty liver disease.

J Dig Dis 2019 Apr 10;20(4):181-188. Epub 2019 Mar 10.

Center for Fatty Liver, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Nonalcoholic fatty liver disease (NAFLD) is a common, multifactorial liver disease that has emerged as a global challenge due to its increasing prevalence and lack of sustainable treatment options. Gut microbiota possess vital functions in fermenting dietary nutrients and synthesizing bioactive molecules. This function is of great importance in maintaining health because these microbial metabolites are essential in regulating energy metabolism, immune response, and other vital physiological processes. Read More

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http://dx.doi.org/10.1111/1751-2980.12709DOI Listing

Relapse patterns and predictors of IgG4-related diseases involved with autoimmune pancreatitis: A single-center retrospective study of 115 patients.

J Dig Dis 2019 Mar;20(3):152-158

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Objective: Autoimmune pancreatitis is an autoimmune disorder accompanied by clinicopathological manifestations that have been established as immunoglobulin (IgG)4-related diseases (IgG4-RD). Other IgG4-RD are often involved with autoimmune pancreatitis. They sometimes relapse despite a favorable response to steroid therapy. Read More

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http://dx.doi.org/10.1111/1751-2980.12708DOI Listing
March 2019
9 Reads

Diagnosis and Management of Pancreatic Adenocarcinoma in the Background of Chronic Pancreatitis: Core Issues.

Dig Dis 2019 30;37(4):315-324. Epub 2019 Jan 30.

Consultant, Department of Gastrointestinal Surgery, Lilavati Hospital and Research Center, Mumbai, India.

Background: The incidence of pancreatic adenocarcinoma (PDAC) in patients with chronic pancreatitis (CP) is as high as 5%. It is a commonly encountered diagnostic challenge in patients with CP on long-term follow-up.

Summary: This review consolidates the existing literature on assessment of PDAC in background of CP, its evaluation through the available investigations, surgical management, and prognostication. Read More

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http://dx.doi.org/10.1159/000496507DOI Listing
January 2019
2 Reads

Endoscopic features of sessile serrated adenoma/polyps under narrowband imaging: A retrospective study.

J Dig Dis 2019 Mar;20(3):135-142

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Objective: Sessile serrated adenoma/polyps (SSA/P) are recognized as precancerous lesions in the colon and resemble hyperplastic polyps (HP). Definite endoscopic features under narrow band imaging (NBI) with or without magnification may help differentiate these two lesions. Our study aimed to identify specific endoscopic features of SSA/P by NBI. Read More

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http://dx.doi.org/10.1111/1751-2980.12706DOI Listing
March 2019
6 Reads

Chinese consensus on the clinical application of hepatobiliary magnetic resonance imaging contrast agent: Gadoxetic acid disodium.

J Dig Dis 2019 Feb 10;20(2):54-61. Epub 2019 Mar 10.

Department of Radiology, Zhongshan Hospital, Fudan University, and Shanghai Institute of Medical Imaging, Shanghai, China.

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http://dx.doi.org/10.1111/1751-2980.12707DOI Listing
February 2019
17 Reads

Gastrointestinal Involvement in Patients with Mantle Cell Lymphoma: A Single Center Experience of Eighty-Five Patients.

Dig Dis 2019 24;37(3):194-200. Epub 2019 Jan 24.

Clinical Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.

Background: The frequency of endoscopically apparent gastrointestinal tract (GI) involvement in patients with mantle cell lymphoma (MCL) at diagnosis is thought to be in the range of 30%. While reports on GI involvement in MCL patients exist, most series lack a strict GI assessment due to the often asymptomatic nature of GI involvement. Owing to the standardized staging routine at our institution including GI assessment at diagnosis, we have analyzed the rate and prognostic impact of GI involvement in MCL. Read More

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https://www.karger.com/Article/FullText/496508
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http://dx.doi.org/10.1159/000496508DOI Listing
March 2019
8 Reads

Consensus on standard biobanking of gut microbiota.

J Dig Dis 2019 Mar 6;20(3):114-121. Epub 2019 Mar 6.

Department of Gastroenterology and Hepatology, Institute of Digestive Diseases, Chinese PLA General Hospital, Beijing, China.

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http://doi.wiley.com/10.1111/1751-2980.12705
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http://dx.doi.org/10.1111/1751-2980.12705DOI Listing
March 2019
16 Reads

Corticotropin-releasing factor induces inflammatory cytokines via the NLRP6-inflammatory cytokine axis in a murine model of irritable bowel syndrome.

J Dig Dis 2019 Mar 5;20(3):143-151. Epub 2019 Mar 5.

Department of Gastroenterology, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.

Objective: This study aimed to determine the effect of corticotropin-releasing factor (CRF) on regulating the NOD-like receptor pyrin domain-containing protein 6 (NLRP6)-inflammatory cytokine axis in a murine model of irritable bowel syndrome (IBS).

Methods: C57BL/6 mice were subjected to water avoidance stress (WAS) for 1 h per day for 10 days, and the abdominal withdrawal reflex (AWR) and colonic inflammation were assessed. We also measured the levels of CRF, NLRP6 inflammasome components, myeloperoxidase, D-lactate, interleukin (IL)-1β, and IL-18. Read More

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http://dx.doi.org/10.1111/1751-2980.12704DOI Listing
March 2019
2 Reads
1.924 Impact Factor

Can Iodixanol Prevent Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis? A Prospective, Randomized, Controlled Trial.

Dig Dis 2019 17;37(3):255-261. Epub 2019 Jan 17.

Second Department of Internal Medicine, Osaka Medical College, Osaka, Japan.

Background: It is yet not clear whether differences in the contrast medium may affect post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP).

Aim: The aim of this study was to evaluate the rate of PEP between high osmolality contrast medium (HOCM) and iso osmolar medium (IOCM) in a prospective, randomized, controlled trial.

Methods: Patients who were scheduled to undergo a diagnostic or therapeutic procedure under ERCP guidance were included. Read More

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https://www.karger.com/Article/FullText/496349
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http://dx.doi.org/10.1159/000496349DOI Listing
March 2019
15 Reads

Transjugular intrahepatic portosystemic shunt prevents rebleeding in cirrhotic patients having cavernous transformation of the portal vein without improving their survival.

J Dig Dis 2019 Feb 3;20(2):89-96. Epub 2019 Mar 3.

Department of Gastroenterology, Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong Province, China.

Objective: To compare the efficacy of transjugular intrahepatic portosystemic shunts (TIPS) and endoscopic variceal ligations (EVL) plus propranolol in decreasing rebleeding and improving survival rates in cirrhotic patients with cavernous transformation of the portal vein (CTPV).

Methods: Cirrhotic patients with CTPV and a history of variceal bleeding who were treated for recurrent variceal bleeding between June 2010 and July 2016 were identified and classified based on the treatment they received (TIPS or EVL plus propranolol). Their characteristics and clinical data were recorded. Read More

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http://dx.doi.org/10.1111/1751-2980.12702DOI Listing
February 2019
9 Reads

Clinical outcomes of endoscopic submucosal dissection for laterally spreading tumors involving the dentate line.

J Dig Dis 2019 Feb 11;20(2):83-88. Epub 2019 Feb 11.

Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China.

Objective: Endoscopic submucosal dissection (ESD) for laterally spreading tumors (LST) involving the dentate line (LST-DL) is challenging because of the specific anatomical features of the anorectum. This study aimed to evaluate the efficacy and safety of ESD for LST-DL.

Methods: Consecutive patients with LST-DL who had undergone ESD at our hospital between January 2010 and December 2015 were retrospectively enrolled in this study. Read More

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http://doi.wiley.com/10.1111/1751-2980.12701
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http://dx.doi.org/10.1111/1751-2980.12701DOI Listing
February 2019
25 Reads

Acid exposure in patients with gastroesophageal reflux disease is associated with esophageal dysmotility.

J Dig Dis 2019 Feb 19;20(2):73-77. Epub 2019 Feb 19.

Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Objective: To explore the correlation between reflux disease and abnormal esophageal motility in patients with gastroesophageal reflux disease (GERD).

Methods: Participants (patients with GERD and controls) who underwent 24-h impedance-pH monitoring (MII-pH monitoring) and high-resolution manometry between January 2012 and February 2017 were retrospectively studied. The patients were divided into two groups (acid reflux and nonacid reflux) based on their MII-pH monitoring data. Read More

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http://doi.wiley.com/10.1111/1751-2980.12703
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http://dx.doi.org/10.1111/1751-2980.12703DOI Listing
February 2019
11 Reads

Diabetic Retinopathy as a Risk Factor Associated with the Development of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease.

Dig Dis 2019 9;37(3):247-254. Epub 2019 Jan 9.

Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.

Background: The risk factors associated with the development of hepatocellular carcinoma (HCC) in nonalcoholic fatty liver disease (NAFLD) are still unclear. The aim of the present study was to identify such risk factors in NAFLD patients who developed HCC.

Methods: Between April 2000 and -December 2016, a total of 182 patients with NAFLD were enrolled in this study; of these, only 22 patients had HCC. Read More

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https://www.karger.com/Article/FullText/493580
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http://dx.doi.org/10.1159/000493580DOI Listing
March 2019
21 Reads

Positive Response to Tolvaptan Treatment Would Be a Good Prognostic Factor for Cirrhotic Patients with Ascites.

Authors:
Yohei Kida

Dig Dis 2019 9;37(3):239-246. Epub 2019 Jan 9.

Department of Internal Medicine, Kainan Municipal Medical Center, Kainan, Japan,

Aims: Ascites is one of the major complications in advanced cirrhotic patients. Tolvaptan is a non-peptide orally available arginine vasopressin V2 receptor antagonist. We investigated and found that tolvaptan therapy improved the prognosis and predictive factor of cirrhotic patients with ascites. Read More

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https://www.karger.com/Article/FullText/494438
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http://dx.doi.org/10.1159/000494438DOI Listing
March 2019
2 Reads

Dexlansoprazole is Effective in Relieving Heartburn during the Fasting Month of Ramadan.

Dig Dis 2019 9;37(3):188-193. Epub 2019 Jan 9.

Division of Gastroenterology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon,

Background And Aims: Proton pump inhibitors are effective at reducing heartburn. No studies have evaluated their efficacy in Ramadan. Dexlansoprazole has a unique active formulation independent of time-of-day dosing or food. Read More

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https://www.karger.com/Article/FullText/496091
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http://dx.doi.org/10.1159/000496091DOI Listing
March 2019
4 Reads