3,048 results match your criteria Digestive Diseases[Journal]


General Aspects of Primary Cancer Prevention.

Dig Dis 2019 Feb 15:1-10. Epub 2019 Feb 15.

Clinic for Gastroenterology and Hepatology, Clinical Canter of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.

Background: Cancer is the second leading cause of death worldwide next to cardiovascular diseases. Despite the advancement in screening, early diagnosis, and development in treatment technology in last several decades, cancer incidence overall, particularly that of gastrointestinal (GI) cancers, is far from being controlled, and is expected to increase worldwide.

Summary: Although numerous preclinical and population-based clinical studies have already made important progress in restraining the overall cancer incidence and mortality, the full potential of preventive strategy is still far from being realized, and remains at an early stage. Read More

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https://www.karger.com/Article/FullText/497191
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http://dx.doi.org/10.1159/000497191DOI Listing
February 2019
1 Read

Should Focal Nodular Hyperplasia Still be Operated Upon? Analysis of a Case Series.

Dig Dis 2019 Feb 14:1-6. Epub 2019 Feb 14.

Department of Integrated Medicine, Federal University of Rio Grande do Norte/University Hospital Onofre Lopes, Natal, Rio Grande do Norte, Brazil.

Background: Focal nodular hyperplasia (FNH) is a frequent benign liver lesion. Its course is considered benign, and there is no recommendation for its treatment. Nevertheless, the literature presents a high incidence of surgery. Read More

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http://dx.doi.org/10.1159/000496430DOI Listing
February 2019

Endoscopic management of patients with early gastric cancers before and after endoscopic resection: a review.

J Dig Dis 2019 Feb 12. Epub 2019 Feb 12.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease, 145 Middle Shandong Road, Shanghai 200001, China.

With endoscopic resection for early gastric cancers (EGCs) widely accepted by not only Asian endoscopists, but also endoscopists from Western countries, there was still lack of review about standardized treatment process before and after endoscopic resection (ER). In this article, we provided a narrative review of studies describing how to choose proper EGCs for endoscopic resection and how to follow up patients with EGCs after histological assessment of ER specimen. Before endoscopic resection, EGCs should be comprehensively assessed, including exact margin, depth of EGCs and risk of lymph node metastasis (LNM). Read More

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http://dx.doi.org/10.1111/1751-2980.12715DOI Listing
February 2019

Management of Bouveret's Syndrome.

J Dig Dis 2019 Feb 12. Epub 2019 Feb 12.

Division of Transplant Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri,, United States.

Bouveret's syndrome is a rare condition characterized by gastric outlet obstruction caused by gallstone impaction in the stomach or duodenum. Gallstones that are too large to pass through the cystic and common bile ducts (CBD) can result in chronic irritation and inflammation of the gallbladder wall. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/1751-2980.12713DOI Listing
February 2019

Systematic Review with Meta-Analysis: Chromoendoscopy versus White Light Endoscopy in Detection of Dysplasia in Patients with Inflammatory Bowel Disease.

J Dig Dis 2019 Feb 12. Epub 2019 Feb 12.

State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.

Aim: To compare chromoendoscopy (CE) and white light endoscopy (WLE) for dysplasia surveillance in inflammatory bowel disease (IBD) patients.

Methods: We conducted a meta-analysis of six RCTs and five prospective studies and performed a comparison between CE and WLE groups. Fixed-effect model was used unless heterogeneity was high. Read More

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http://dx.doi.org/10.1111/1751-2980.12714DOI Listing
February 2019

Circulating miR-29b positively correlates with non-alcoholic fatty liver disease in a Chinese population.

J Dig Dis 2019 Feb 12. Epub 2019 Feb 12.

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Aim: The early screening of non-alcoholic fatty liver disease (NAFLD) is of great significance for early detection and intervention in NAFLD. MicroRNAs (miRNAs) are important regulators of metabolic disease, including NAFLD. The aim of this study was to examine the association of serum miR-29a-c with NAFLD in a Chinese population. Read More

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http://dx.doi.org/10.1111/1751-2980.12716DOI Listing
February 2019
1 Read

Single-Dose Linaclotide Is Equal in Efficacy to Polyethylene Glycol for Bowel Preparation Prior to Capsule Endoscopy.

Dig Dis 2019 Feb 7:1-6. Epub 2019 Feb 7.

Motility Lab, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia,

Background: Video capsule endoscopy provides noninvasive visualization of the small bowel, but yield is often limited by debris. At our institution, preparation with polyethylene glycol (PEG) and simethicone is used to improve visualization.

Aims: We hypothesized that linaclotide and simethicone would yield equal to better results. Read More

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https://www.karger.com/Article/FullText/496350
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http://dx.doi.org/10.1159/000496350DOI Listing
February 2019
3 Reads

Validation of Tokyo Guideline 2013 as Treatment of Acute Cholecystitis by Real World Data.

Dig Dis 2019 Feb 7:1-6. Epub 2019 Feb 7.

Department of Gastroenterology, Yamanashi Prefectural Central Hospital, Yamanashi, Japan.

Background: The Tokyo Guidelines (TG; 2013) indicated that emergency cholecystectomy is an important early treatment option for acute cholecystitis; however, surgical intervention is not necessarily indicated in patients with advanced age. We evaluated percutaneous transhepatic gallbladder aspiration (PTGBA), percutaneous transhepatic gallbladder drainage (PTGBD), and the administration of antibiotics alone as treatment options for acute -cholecystitis.

Methods: From January 2010 to December 2017, 159 patients with acute cholecystitis were treated at our institution. Read More

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http://dx.doi.org/10.1159/000496738DOI Listing
February 2019
1 Read

Diabetes Mellitus and Age are Risk Factors of Interval Colon Cancer: A Case-Control Study.

Dig Dis 2019 Feb 7:1-6. Epub 2019 Feb 7.

Gastroenterology and Hepatology Institute, Meir Medical Center, Kfar Saba, Israel.

Background And Aims: Interval colorectal cancer (CRC) is largely related to a poor endoscopic performance or different biology in the development of the polyp. However, patient-related factors were less investigated for their association with interval cancer. We thus evaluated tumor and patient characteristics as predictors of interval cancer in a population from Israel. Read More

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http://dx.doi.org/10.1159/000496740DOI Listing
February 2019

Unmet Medical Needs in Ulcerative Colitis: An Expert Group Consensus.

Dig Dis 2019 Feb 6:1-18. Epub 2019 Feb 6.

University Hospital Leuven, Leuven,

Background: The authors aimed to conduct an extensive literature review and consensus meeting to identify unmet needs in ulcerative colitis (UC) and ways to overcome them. UC is a relapsing and remitting inflammatory bowel disease with varied, and changing, incidence rates worldwide. UC has an unpredictable disease course and is associated with a high health economic burden. Read More

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http://dx.doi.org/10.1159/000496739DOI Listing
February 2019
2 Reads
1.832 Impact Factor

Value of contrast-enhanced harmonic endoscopic ultrasonography inthedifferentiationof gastrointestinal stromal tumors: a meta-analysis.

J Dig Dis 2019 Feb 3. Epub 2019 Feb 3.

Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Objective: Ensuring the diagnosis and determining the malignant potential of gastrointestinal stromal tumors (GISTs) as early as possible is important when making clinical therapeutic decisions. Contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) is a valuable method for this task. This study aimed to estimate the ability of CH-EUS to discriminate GISTs from benign submucosal lesions (SMLs) and predict their malignant potential. Read More

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http://dx.doi.org/10.1111/1751-2980.12710DOI Listing
February 2019
1 Read

Quantitative immunochemical fecal occult blood test for neoplasia in colon cancer screening.

J Dig Dis 2019 Feb 3. Epub 2019 Feb 3.

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing, China.

Objectives: To investigate the performance of the quantitative immunochemical fecal occult blood test (qFIT), and determine the association between the fecal hemoglobin (Hb) level and the location, size of adenomas and the grades of colorectal cancer (CRC).

Methods: A total of 692 participants were included in the study. The fecal Hb level was measured using an OC-SENSA MICRO qFIT. Read More

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http://dx.doi.org/10.1111/1751-2980.12711DOI Listing
February 2019
1 Read

Fecal occult blood test in colorectal cancer screening.

J Dig Dis 2019 Feb 3. Epub 2019 Feb 3.

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing, China.

Colorectal cancer (CRC) is currently the second leading cause of cancer-related mortality worldwide. CRC screening can reduce the mortality of CRC. The most important stool test for CRC screening is the fecal occult blood test (FOBT) which includes gFOBT and FIT. Read More

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http://dx.doi.org/10.1111/1751-2980.12712DOI Listing
February 2019
1 Read

Role of gut microbial metabolites in nonalcoholic fatty liver disease.

J Dig Dis 2019 Jan 31. Epub 2019 Jan 31.

Center for Fatty Liver, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Nonalcoholic fatty liver disease (NAFLD) is a common, multifactorial liver disease and has emerged as a global challenge due to the increasing prevalence and lack of sustainable treatment options. The gut microbiota possesses vital functions in fermenting dietary nutrients and synthesizing bioactive molecules. This function is of great importance in maintaining health because these microbial metabolites are essential in regulating energy metabolism, immune response and other vital physiological processes. Read More

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http://dx.doi.org/10.1111/1751-2980.12709DOI Listing
January 2019

Relapse patterns and predictors of IgG4-related diseases involved with autoimmune pancreatitis: A single-center retrospective study of 115 patients.

J Dig Dis 2019 Jan 31. Epub 2019 Jan 31.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Objective: Autoimmune pancreatitis (AIP) was autoimmune disorder accompanied by clinicopathological manifestation whose concept was established as IgG4-related disease (IgG4-RD). Other IgG4-RDs are often involved with autoimmune pancreatitis, sometimes relapsing despite the favorable response to a steroid therapy. This study aimed to clarify patterns and risk factors for extrapancreatic relapse. Read More

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http://dx.doi.org/10.1111/1751-2980.12708DOI Listing
January 2019
2 Reads

Diagnosis and Management of Pancreatic Adenocarcinoma in the Background of Chronic Pancreatitis: Core Issues.

Dig Dis 2019 Jan 30:1-10. Epub 2019 Jan 30.

Consultant, Department of Gastrointestinal Surgery, Lilavati Hospital and Research Center, Mumbai, India.

Background: The incidence of pancreatic adenocarcinoma (PDAC) in patients with chronic pancreatitis (CP) is as high as 5%. It is a commonly encountered diagnostic challenge in patients with CP on long-term follow-up.

Summary: This review consolidates the existing literature on assessment of PDAC in background of CP, its evaluation through the available investigations, surgical management, and prognostication. Read More

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http://dx.doi.org/10.1159/000496507DOI Listing
January 2019
1 Read

Endoscopic Features of Sessile Serrated Adenoma/Polyps under Narrow Band Imaging: A Retrospective study.

J Dig Dis 2019 Jan 28. Epub 2019 Jan 28.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.

Objective: Sessile serrated adenoma/polyps (SSA/Ps) are recognized as precancerous lesions in the colon and resemble hyperplastic polyps (HPs). Definite endoscopic features under narrow band imaging (NBI) with or without magnification may help differentiate between these two lesions. Our study was designed to identify specific endoscopic features of SSA/Ps by NBI. Read More

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http://dx.doi.org/10.1111/1751-2980.12706DOI Listing
January 2019
1 Read

Chinese consensus on the clinical application of hepatobiliary MR imaging contrast agent - Gd-EOB-DTPA.

J Dig Dis 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiology, Zhongshan Hospital, Fudan University and Shanghai Medical Imaging Institute, Shanghai, China.

Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) helps improve the ability of detection and diagnosis of focal hepatic lesions, especially for evaluating smaller lesions (<1 cm in diameter) and the diseases of the biliary system. MRI-based function tests with Gd-EOB-DTPA have gained immense popularity in recent years as it can be integrated into clinical setup with a higher temporal and spatial resolution and without ionizing radiation. Gd-EOB-DTPA has been in use since 2011 in China. Read More

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http://dx.doi.org/10.1111/1751-2980.12707DOI Listing
January 2019
6 Reads

Gastrointestinal Involvement in Patients with Mantle Cell Lymphoma: A Single Center Experience of Eighty-Five Patients.

Dig Dis 2019 Jan 24:1-7. Epub 2019 Jan 24.

Clinical Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.

Background: The frequency of endoscopically apparent gastrointestinal tract (GI) involvement in patients with mantle cell lymphoma (MCL) at diagnosis is thought to be in the range of 30%. While reports on GI involvement in MCL patients exist, most series lack a strict GI assessment due to the often asymptomatic nature of GI involvement. Owing to the standardized staging routine at our institution including GI assessment at diagnosis, we have analyzed the rate and prognostic impact of GI involvement in MCL. Read More

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https://www.karger.com/Article/FullText/496508
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http://dx.doi.org/10.1159/000496508DOI Listing
January 2019
3 Reads

China Medicinal Biotech Association, Chinese Association of Digestive Disease and Chinese Society of Gastroenterology Consensus on standard biobanking of the gut microbiota.

J Dig Dis 2019 Jan 24. Epub 2019 Jan 24.

Department of Gastroenterology and Hepatology, Institute of Digestive Diseases, Chinese PLA General Hospital, Beijing, China.

Biobanks are collections of various biological samples and their related information. These samples include organs, tissues, cells, blood, body fluids, secretions, excretions and biological macromolecular derivatives from healthy or diseased individuals that are collected, processed, stored and utilized under standard procedures. Sample-related information consists of clinical information, test results, pathology, imaging, treatment, follow-up visits and informed patient consent as well as quality control, information management and application systems associated with the samples. Read More

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http://doi.wiley.com/10.1111/1751-2980.12705
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http://dx.doi.org/10.1111/1751-2980.12705DOI Listing
January 2019
6 Reads

Corticotropin-releasing factor induces inflammatory cytokines via the NLRP6-inflammatory cytokine axis in a murine model of irritable bowel syndrome.

J Dig Dis 2019 Jan 20. Epub 2019 Jan 20.

Department of Gastroenterology, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China.

Aim: As a stress-related disorder, irritable bowel syndrome (IBS) has aberrant brain-gut communication and low-grade inflammation in the intestine. This study determined the effect of corticotropin-releasing factor (CRF) on regulating the NOD-like receptor pyrin domain-containing protein 6 (NLRP6)- inflammatory cytokine axis in a murine model of IBS.

Methods: C57BL/6 mice were subjected to water avoidance stress (WAS) for 1 h/day over the course of 10 days. Read More

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http://dx.doi.org/10.1111/1751-2980.12704DOI Listing
January 2019
2 Reads
1.924 Impact Factor

Can Iodixanol Prevent Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis? A Prospective, Randomized, Controlled Trial.

Dig Dis 2019 Jan 17:1-7. Epub 2019 Jan 17.

Background: It is yet not clear whether differences in the contrast medium may affect post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP).

Aim: The aim of this study was to evaluate the rate of PEP between high osmolality contrast medium (HOCM) and iso osmolar medium (IOCM) in a prospective, randomized, controlled trial.

Methods: Patients who were scheduled to undergo a diagnostic or therapeutic procedure under ERCP guidance were included. Read More

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https://www.karger.com/Article/FullText/496349
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http://dx.doi.org/10.1159/000496349DOI Listing
January 2019
7 Reads

Transjugular intrahepatic portosystemic shunt prevents rebleeding in cirrhotic patients with cavernous transformation of the portal vein without improving survival.

J Dig Dis 2019 Jan 10. Epub 2019 Jan 10.

Department of Gastroenterology, Provincial Hospital Affiliated to Shandong University, Jinan, China.

Aim: The efficacies in decreasing rebleeding and improving survival rate by transjugular intrahepatic portosystemic shunt(TIPS) and endoscopic variceal ligation(EVL) plus propranolol were compared in cirrhotic patients with cavernous transformation of the portal vein(CTPV).

Methods: Cirrhotic patients with CTPV and variceal bleeding history treated for a second prophylaxis of recurrent variceal bleeding between June 2010 and July 2016 were identified and classified based on the treatment that they received (TIPS or EVL + propranolol). Patients' demographics and clinical data were recorded. Read More

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http://dx.doi.org/10.1111/1751-2980.12702DOI Listing
January 2019
2 Reads

Clinical outcomes of endoscopic submucosal dissection for laterally spreading tumors involving the dentate line.

J Dig Dis 2019 Jan 10. Epub 2019 Jan 10.

Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China.

Objective: Endoscopic submucosal dissection (ESD) for laterally spreading tumors (LST) involving the dentate line (LST-DL) is challenging because of the specific anatomical features of the anorectum. This study aimed to evaluate the efficacy and safety of ESD for LST-DL.

Methods: Consecutive patients with LST-DL who had undergone ESD at our hospital between January 2010 and December 2015 were retrospectively enrolled in this study. Read More

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http://doi.wiley.com/10.1111/1751-2980.12701
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http://dx.doi.org/10.1111/1751-2980.12701DOI Listing
January 2019
14 Reads

Acid exposure in patients with gastroesophageal reflux disease is associated with esophageal dysmotility.

J Dig Dis 2019 Jan 10. Epub 2019 Jan 10.

Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.

Objective: To explore the correlation between reflux disease and abnormal esophageal motility in patients with gastroesophageal reflux disease (GERD).

Methods: Participants (patients with GERD and controls) who underwent 24-h impedance-pH monitoring (MII-pH monitoring) and high-resolution manometry between January 2012 and February 2017 were retrospectively studied. The patients were divided into two groups (acid reflux and nonacid reflux) based on their MII-pH monitoring data. Read More

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http://doi.wiley.com/10.1111/1751-2980.12703
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http://dx.doi.org/10.1111/1751-2980.12703DOI Listing
January 2019
7 Reads

Diabetic Retinopathy as a Risk Factor Associated with the Development of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease.

Dig Dis 2019 Jan 9:1-8. Epub 2019 Jan 9.

Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.

Background: The risk factors associated with the development of hepatocellular carcinoma (HCC) in nonalcoholic fatty liver disease (NAFLD) are still unclear. The aim of the present study was to identify such risk factors in NAFLD patients who developed HCC.

Methods: Between April 2000 and -December 2016, a total of 182 patients with NAFLD were enrolled in this study; of these, only 22 patients had HCC. Read More

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https://www.karger.com/Article/FullText/493580
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http://dx.doi.org/10.1159/000493580DOI Listing
January 2019
15 Reads

Positive Response to Tolvaptan Treatment Would Be a Good Prognostic Factor for Cirrhotic Patients with Ascites.

Authors:
Yohei Kida

Dig Dis 2019 Jan 9:1-8. Epub 2019 Jan 9.

Aims: Ascites is one of the major complications in advanced cirrhotic patients. Tolvaptan is a non-peptide orally available arginine vasopressin V2 receptor antagonist. We investigated and found that tolvaptan therapy improved the prognosis and predictive factor of cirrhotic patients with ascites. Read More

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https://www.karger.com/Article/FullText/494438
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http://dx.doi.org/10.1159/000494438DOI Listing
January 2019
2 Reads

Dexlansoprazole is Effective in Relieving Heartburn during the Fasting Month of Ramadan.

Dig Dis 2019 Jan 9:1-6. Epub 2019 Jan 9.

Background And Aims: Proton pump inhibitors are effective at reducing heartburn. No studies have evaluated their efficacy in Ramadan. Dexlansoprazole has a unique active formulation independent of time-of-day dosing or food. Read More

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https://www.karger.com/Article/FullText/496091
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http://dx.doi.org/10.1159/000496091DOI Listing
January 2019
3 Reads

Chinese expert consensus on perioperative medications for endoscopic retrograde cholangiopancreatography (ERCP).

J Dig Dis 2019 Jan 2. Epub 2019 Jan 2.

Department of Gastroenterology, Changhai Hospital, The Naval Medical University (Second Military Medical University), Shanghai, China.

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http://dx.doi.org/10.1111/1751-2980.12699DOI Listing
January 2019
3 Reads

Gastro Update Europe 2018.

Authors:
Guido N J Tytgat

Dig Dis 2019 Jan 2:1-13. Epub 2019 Jan 2.

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http://dx.doi.org/10.1159/000495705DOI Listing
January 2019
1 Read

Pseudoachalasia as First Manifestation of a Malignancy.

Dig Dis 2019 Jan 2:1-8. Epub 2019 Jan 2.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz,

Pseudoachalasia is a condition in which symptoms, radiologic, endoscopic, and manometric findings mimick idiopathic achalasia. About 4% of patients with a typical constellation for idiopathic achalasia will turn out to have pseudoachalasia, posing a major diagnostic challenge. A large spectrum of underlying causes of pseudoachalasia has been described. Read More

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http://dx.doi.org/10.1159/000495758DOI Listing
January 2019
2 Reads

Gastroduodenal Symptoms in Inflammatory Bowel Disease Are Correlated with Gastric Emptying and Serum Levels of Active Ghrelin.

Dig Dis 2019 Jan 2:1-8. Epub 2019 Jan 2.

Department of Clinical Medicine, Federal University of Ceará, Fortaleza,

Background: Inflammatory bowel disease (IBD) is associated with delay in gastric emptying, increase in ghrelin, and decrease in leptin. The aim was to investigate the correlation between gastroduodenal (GD) symptoms, gastric emptying, and serum levels of active ghrelin and leptin in IBD. Twenty-seven IBD patients and 26 healthy volunteers were asked to complete the Porto Alegre Dyspeptic Symptoms Questionnaire. Read More

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http://dx.doi.org/10.1159/000494920DOI Listing
January 2019
1 Read

Loss of response to scheduled infliximab therapy for Crohn's disease in adults: A systematic review and meta-analysis.

J Dig Dis 2018 Dec 23. Epub 2018 Dec 23.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology, Ministry of Health, Inflammatory Bowel Disease Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease, Shanghai, China.

Objective: We aimed to determine the potential predictors of loss of response (LOR) to infliximab (IFX) therapy for Crohn's disease (CD) in adults.

Methods: We searched for English-language articles published between 1990 and March 2017 in PubMed, Embase, and the Cochrane Library. After identifying eligible studies, data extraction was performed independently by two reviewers. Read More

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http://dx.doi.org/10.1111/1751-2980.12698DOI Listing
December 2018
1 Read

Corticosteroid therapy in drug-induced liver injury: Pros and cons.

J Dig Dis 2018 Dec 23. Epub 2018 Dec 23.

Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Drug-induced liver injury (DILI) is a liver toxicity induced by a drug or its metabolite. The incidence of DILI continues to increase and it has been an enormous challenge worldwide, while the prognosis is not optimistic. Currently, the most effective treatment for DILI is to suspend the offending drug(s) and to avoid re-exposure, with no definitive therapy available for idiosyncratic DILI with or without acute liver failure. Read More

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http://dx.doi.org/10.1111/1751-2980.12697DOI Listing
December 2018
2 Reads

Splenic marginal zone lymphoma leads to sinistral portal hypertension.

J Dig Dis 2019 Jan;20(1):45-48

Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1751-2980.12
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http://dx.doi.org/10.1111/1751-2980.12696DOI Listing
January 2019
12 Reads

Sofosbuvir plus ribavirin for the treatment of hepatitis C virus genotype 2 in Korea: What's the optimal dosage of ribavirin in real-world setting?

J Dig Dis 2019 Jan;20(1):31-37

Department of Internal Medicine, Mokpo Hankook Hospital, Mokpo, South Korea.

Objective: This study aimed to investigate the efficacy and safety of sofosbuvir plus ribavirin for the treatment of hepatitis C virus (HCV) genotype 2 infection and to determine the optimal ribavirin dosage.

Methods: From May 2016 to March 2017, 199 patients received sofosbuvir plus ribavirin treatment for HCV genotype 2 infection at four centers in Jeollanam-do Province, Korea. After excluding patients lost to follow-up and those with insufficient data, we retrospectively assessed the data for 194 patients. Read More

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http://dx.doi.org/10.1111/1751-2980.12695DOI Listing
January 2019
1 Read

Accuracy and Pitfalls in the Assessment of Early Gastrointestinal Lesions.

Dig Dis 2018 Dec 12:1-10. Epub 2018 Dec 12.

Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Belgrade, Serbia.

Superficial neoplastic lesions of the digestive tract are usually asymptomatic, and often represent incidental findings on endoscopy. The Paris Classification was developed for the systematic evaluation of superficial lesions of the oesophagus, stomach and colon. The significance of this classification in clinical practice is that it allows the depth of invasion to be estimated. Read More

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http://dx.doi.org/10.1159/000495849DOI Listing
December 2018
5 Reads
1.832 Impact Factor

The "Difficult" Colorectal Polyps and Adenomas: Practical Aspects.

Dig Dis 2018 Dec 12:1-6. Epub 2018 Dec 12.

Background: Colonoscopy is the gold standard for adenoma detection. All endoscopists who perform colonoscopy must by mandate be skilled to perform polypectomy. However, there are significant differences between endoscopists in terms of the polyp detection rate and in the effectiveness of polypectomy. Read More

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http://dx.doi.org/10.1159/000495694DOI Listing
December 2018
8 Reads

Positive endoscopic and ultrasonographic findings in patients with symptom-diagnosed functional gastrointestinal disorder: Data from a Chinese cross-sectional study.

J Dig Dis 2018 Dec;19(12):759-765

Division of Gastroenterology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Objective: Few studies have systematically assessed symptom-based diagnoses of functional gastrointestinal disorders (FGID) in China. This study aimed to evaluate the positive endoscopic and ultrasonographic findings in patients with symptom-based FGID.

Methods: Adult patients with gastrointestinal symptoms but not red flag symptoms who were empirically diagnosed with FGID underwent an upper or lower gastrointestinal endoscopy. Read More

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http://doi.wiley.com/10.1111/1751-2980.12693
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http://dx.doi.org/10.1111/1751-2980.12693DOI Listing
December 2018
10 Reads
1.924 Impact Factor

Changes in the distal esophageal microbiota in Chinese patients with reflux esophagitis.

J Dig Dis 2019 Jan 27;20(1):18-24. Epub 2018 Dec 27.

Department of Gastroenterology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Objective: Changes in microbiota composition in the distal esophagus may be associated with the pathogenesis of gastroesophageal reflux disease. We aimed to compare the composition of distal esophageal microbiota between Chinese patients with reflux esophagitis (RE) and healthy volunteers using metagenomic high-throughput DNA sequencing and bioinformatic analyses.

Methods: Healthy volunteers (controls) and patients with reflux esophagitis (RE) were enrolled. Read More

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http://doi.wiley.com/10.1111/1751-2980.12692
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http://dx.doi.org/10.1111/1751-2980.12692DOI Listing
January 2019
20 Reads

Upregulation of Fibroblast Growth Factor 19 Is Associated with the Initiation of Colorectal Adenoma.

Dig Dis 2018 Dec 5:1-12. Epub 2018 Dec 5.

Department of Gastroenterology, Translational Gastroenterology Laboratory, Shandong University, Qilu Hospital, Shandong,

Fibroblast growth factor 19 (FGF19) promotes tumor growth in various types of cancer, but its function has not been investigated in the context of colorectal adenoma. Here, we report that FGF19 expression was greater in colorectal adenoma than in normal tissues, as measured by an enzyme-linked immunosorbent assay, quantitative reverse-transcription PCR and immunohistochemistry. FGF19 expression was also elevated in a subset of human colon cancer cell lines. Read More

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https://www.karger.com/Article/FullText/494454
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http://dx.doi.org/10.1159/000494454DOI Listing
December 2018
10 Reads

A single-center experience with methotrexate in the treatment of Chinese Crohn's disease patients.

J Dig Dis 2018 Dec;19(12):753-758

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Inflammatory Bowel Disease Research Center, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Objective: Methotrexate (MTX) can be used as an alternative for patients with Crohn's disease (CD) who are intolerant of thiopurine. This retrospective study aimed to provide some clues about MTX treatment in Chinese patients with CD.

Methods: Medical records of 27 adult patients with CD who were treated with MTX between 2012 and 2017 at Renji Hospital were reviewed. Read More

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http://dx.doi.org/10.1111/1751-2980.12694DOI Listing
December 2018
15 Reads

Steroid treatment in patients with acute-on-chronic liver failure precipitated by hepatitis B: A 10-year cohort study in a university hospital in East China.

J Dig Dis 2019 Jan;20(1):38-44

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.

Objective: To investigate retrospectively the efficacy of steroids in patients with acute-on-chronic liver failure (ACLF) precipitated by hepatitis B.

Methods: Patients with ACLF precipitated by hepatitis B were included and categorized according to treatment modalities (steroid vs. control). Read More

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http://dx.doi.org/10.1111/1751-2980.12691DOI Listing
January 2019
1 Read

Circular incision and cutting, a novel treatment for patients with esophageal cancer with anastomotic stricture after esophagectomy.

J Dig Dis 2019 Jan 27;20(1):25-30. Epub 2018 Dec 27.

Department of Gastroenterology, Xinqiao Hospital, Army Medical University, Chongqing, China.

Objective: Endoscopic balloon dilation (EBD) is still considered the standard treatment for patients with anastomotic strictures after esophagectomy. However, repeated dilation sessions are often required to maintain the lumen patency. We therefore developed a novel method called circular incision and cutting (CIC) and compared the efficacy of CIC and EBD among patients with anastomotic strictures after esophagectomy or gastrectomy. Read More

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http://doi.wiley.com/10.1111/1751-2980.12689
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http://dx.doi.org/10.1111/1751-2980.12689DOI Listing
January 2019
10 Reads
1.924 Impact Factor

Differential clustering of fecal and mucosa-associated microbiota in 'healthy' individuals.

J Dig Dis 2018 Dec;19(12):745-752

Department of Microbiology, Tumor and Cell Biology & Science for Life Laboratory, Karolinska Institute, Solna, Sweden.

Objective: Fecal samples are often used to characterize gut microbiota. However, whether or not fecal microbiota differs from mucosa-associated microbiota remains largely unknown. This may be specifically relevant in conditions that are characterized by complex mucosal microbe-host interactions, such as Crohn's disease. Read More

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http://dx.doi.org/10.1111/1751-2980.12688DOI Listing
December 2018
9 Reads

Is Liver Ultrasound Useful as Part of the Surveillance Strategy following Potentially Curative Colorectal Cancer Resection?

Dig Dis 2018 Nov 22:1-5. Epub 2018 Nov 22.

Department of General Surgery, Aberdeen Royal Infirmary, Aberdeen, United Kingdom.

Background: Optimal surveillance monitoring following curative resection of colorectal cancer remains unclear. Guidelines recommend computed tomography (CT)-based imaging for the initial 3 years following surgical intervention due to the high rates of local and distant recurrence. However, there is currently limited supporting evidence for this strategy. Read More

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http://dx.doi.org/10.1159/000495114DOI Listing
November 2018
11 Reads

Novel Magnified Single-Balloon Enteroscopy Enables Observation of Jejunal White Spots Associated with Lymphangiectasia.

Dig Dis 2019 22;37(2):170-174. Epub 2018 Nov 22.

A 59-year-old woman was diagnosed with primary intestinal lymphangiectasia (PIL), with characteristic findings on capsule enteroscopy and confirmation by histopathological examination of biopsy specimens. We viewed the abnormal jejunal mucosa using a newly developed magnifying single-balloon enteroscope (SIF-Y0007). Conventional observation showed leakage of chyle. Read More

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http://dx.doi.org/10.1159/000493578DOI Listing
February 2019
2 Reads

Guidelines of prevention and treatment for alcoholic liver disease (2018, China).

J Dig Dis 2018 Nov 18. Epub 2018 Nov 18.

Department of Gastroenterology, XinHua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Children's Digestion and Nutrition, Shanghai, China.

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http://doi.wiley.com/10.1111/1751-2980.12687
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http://dx.doi.org/10.1111/1751-2980.12687DOI Listing
November 2018
15 Reads

Guidelines of prevention and treatment of nonalcoholic fatty liver disease (2018, China).

J Dig Dis 2018 Nov 16. Epub 2018 Nov 16.

Peking University Health Science Center, Beijing, China.

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http://doi.wiley.com/10.1111/1751-2980.12685
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http://dx.doi.org/10.1111/1751-2980.12685DOI Listing
November 2018
16 Reads

The role of dietary factors in inflammatory bowel diseases: New perspectives.

J Dig Dis 2019 Jan 4;20(1):11-17. Epub 2018 Dec 4.

Department of Clinical Nutrition, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

The current review aimed to elucidate the role of diet in every stage of inflammatory bowel diseases, from aspects of prevention, treatment and rehabilitation. Western diet, characterized by overconsumption of refined sugar and saturated fat and low consumption of dietary fiber, may partly be blamed for its pathogenesis. Some immune-modulated nutrients (fibers, monounsaturated fatty acids, n-3 polyunsaturated fatty acids and vitamin D) exert their potential beneficial effects on gut microbiota and immune function, resulting in clinical remission and/or preventing relapse. Read More

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http://doi.wiley.com/10.1111/1751-2980.12686
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http://dx.doi.org/10.1111/1751-2980.12686DOI Listing
January 2019
13 Reads
1.924 Impact Factor