4,474 results match your criteria Digestion[Journal]


A Potassium-Competitive Acid Blocker-Based Regimen as Second-Line Therapy Improves Helicobacter pylori Eradication.

Digestion 2019 Apr 16:1-7. Epub 2019 Apr 16.

Department of Gastroenterology, Utsunomiya Memorial Hospital, Utsunomiya, Japan.

Background/aims: Although a potassium-competitive acid blocker (PCAB)-based regimen improves the rate of successful Helicobacter pylori first-line eradication, the efficacy of a PCAB-based regimen as second-line therapy is unclear. The aim of this study is to compare the success of second-line eradication of H. pylori using PCAB and proton pump inhibitor (PPI)-based regimens. Read More

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https://www.karger.com/Article/FullText/499857
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http://dx.doi.org/10.1159/000499857DOI Listing
April 2019
1 Read

Changes of Dyspeptic Symptom after Successful Eradication in Helicobacter pylori-Associated Dyspepsia.

Digestion 2019 Apr 16:1-9. Epub 2019 Apr 16.

Department of Gastroenterology and Hepatology, Hokkaido University Faculty of Medicine, Sapporo, Japan.

Background: Helicobacter pylori (H. pylori) gastritis could cause dyspepsia, and eradication is recommended as the first-line treatment. Patients who continuously have their symptoms under control > 6 months after eradication are defined as having H. Read More

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http://dx.doi.org/10.1159/000497432DOI Listing

Evaluating the Accuracy of the Endoscopic ABC Classification System in Diagnosing Helicobacter pylori-Infected Gastritis.

Digestion 2019 Apr 12:1-10. Epub 2019 Apr 12.

Department of General Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Aims: Evaluating the accuracy of the modified Endoscopic ABC (Endo ABC) classification with an electronic endoscopy with narrow band imaging without magnification in diagnosing Helicobacter pylori (H. pylori)-infected gastritis.

Methods: A total of 576 patients were enrolled and they underwent modified Endo ABC. Read More

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http://dx.doi.org/10.1159/000498966DOI Listing

An International Study on the Diagnostic Accuracy of the Japan Narrow-Band Imaging Expert Team Classification for Colorectal Polyps Observed with Blue Laser Imaging.

Digestion 2019 Apr 12:1-8. Epub 2019 Apr 12.

Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: The Japan narrow-band imaging Expert Team (JNET) classification of colorectal polyps based on magnifying endoscopy is used in Japan, but not worldwide. The objective of this study was to clarify differences of diagnostic accuracy between JNET users in Japan and non-JNET users in other countries.

Methods: A total of 185 colorectal tumors were assessed. Read More

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http://dx.doi.org/10.1159/000499856DOI Listing
April 2019
2.032 Impact Factor

Assessment of the Quality and Content of Clinical Practice Guidelines on Irritable Bowel Syndrome Using the AGREE II Instrument.

Digestion 2019 Apr 10:1-11. Epub 2019 Apr 10.

Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China,

Objectives: The aim of the study was to assess the quality of guidelines on irritable bowel syndrome (IBS) using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument and identify concordance of different commendations.

Materials And Methods: A systematic search was undertaken from inception to May 2018. Two reviewers independently selected the titles and abstracts. Read More

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http://dx.doi.org/10.1159/000499838DOI Listing
April 2019
3 Reads

Clinicopathological and Molecular Findings of Differentiated-Type Minute Gastric Intramucosal Neoplasia.

Digestion 2019 Apr 3:1-11. Epub 2019 Apr 3.

Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan.

Background/aims: To evaluate gastric early differentiate-type carcinogenesis, we attempted to identify clinicopathological and biological differences in differentiated-type minute intramucosal neoplasia (MIMN), which was defined as a tumor with a diameter of < 5 mm.

Methods: We examined clinicopathological findings and biological factors, including TP53 overexpression, mucin phenotype, Ki-67-positive rate, MLH1, intranuclear accumulation of β-catenin, and DNA methylation status (low methylation epigenotype [LME], intermediate methylation epigenotype, and high methylation epigenotype [HME]) in MIMNs. In addition, non-MIMNs were also analyzed. Read More

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http://dx.doi.org/10.1159/000499464DOI Listing
April 2019
1 Read

Diagnostic Yield of Colon Capsule Endoscopy in Detection of Superficial Colorectal Lesions.

Digestion 2019 Mar 27:1-8. Epub 2019 Mar 27.

Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan.

Background: The efficacy of second-generation PillCam -COLON2 capsule endoscopy (CCE2) in detecting colorectal superficial lesions remains unclear.

Objective: We sought to determine the diagnostic yield of CCE2 in the detection of colorectal superficial lesions.

Methods: We performed CCE2 in 60 consecutive patients between April 2011 and -December 2017. Read More

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http://dx.doi.org/10.1159/000499332DOI Listing
March 2019
1 Read

Risk of Lymph Node Metastasis in Patients with the Superficial Spreading Type of Esophageal Squamous Cell Carcinoma.

Digestion 2019 Mar 25:1-6. Epub 2019 Mar 25.

Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.

Background: Little is known about the clinicopathological characteristics of superficial spreading-type esophageal carcinoma extending ≥5 cm along the long axis of the esophagus. This study was aimed at investigating the frequency of lymph node metastasis (LNM) in patients with superficial spreading-type esophageal carcinoma.

Methods: We reviewed the data of 320 patients with superficial esophageal squamous cell carcinoma who had undergone esophagectomy with lymph node dissection at our hospital between 1986 and 2010. Read More

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http://dx.doi.org/10.1159/000499017DOI Listing
March 2019
1 Read

Capsule Endoscopy after Hematopoietic Stem Cell Transplantation Can Predict Transplant-Related Mortality.

Digestion 2019 03 22:1-10. Epub 2019 Mar 22.

Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.

Background And Objectives: Allogenic hematopoietic stem cell transplantation (allo-SCT) is a curative therapy for hematological malignancies, but transplant-related mortality (TRM) remains a concern. This study aimed to determine the efficacy of capsule endoscopy (CE) by evaluating the correlation between inflammatory findings on CE and TRM.

Methods: The data of patients after allo-SCT were retrospectively collected. Read More

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http://dx.doi.org/10.1159/000498846DOI Listing
March 2019
1 Read

Effect of EP1 Receptor Antagonist on Transient Lower Esophageal Sphincter Relaxations in Humans.

Digestion 2019 Mar 21:1-9. Epub 2019 Mar 21.

Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background/aims: Transient lower esophageal sphincter relaxations (TLESRs) are the major cause of gastroesophageal reflux. Recently, an EP1 receptor antagonist, ONO-8539, showed the reduction of TLESRs in monkeys. However, its effect on TLESRs in humans remains unclear. Read More

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http://dx.doi.org/10.1159/000499333DOI Listing
March 2019
2 Reads

Efficacy of Vonoprazan, a Novel Potassium-Competitive Acid Blocker, in Patients with Proton Pump Inhibitor-Refractory Acid Reflux.

Digestion 2019 03 21:1-10. Epub 2019 Mar 21.

Department of Medicine and Molecular Science, Gunma University, Maebashi, Japan

Background/aim: We evaluated the efficacy of vonoprazan (VPZ), a novel potassium-competitive acid blocker, in patients with proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD), exhibiting continued pathological esophageal acid exposure (EAE).

Methods: Despite ≥8 weeks of appropriate PPI therapy, patients with -persistent reflux symptoms and pathological EAE times (EAETs ≥4%) were invited to switch to VPZ treatment. After an 8-week-course of once-daily VPZ (20 mg), multichannel intraluminal impedance-pH (MII-pH) monitoring was repeated to compare gastric acid exposure times (GAETs), EAETs, and other reflux parameters relative to the baseline values. Read More

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http://dx.doi.org/10.1159/000497775DOI Listing
March 2019
4 Reads

Clinical Factors Associated with Missing Colorectal Polyp on Colon Capsule Endoscopy.

Digestion 2019 Mar 19:1-7. Epub 2019 Mar 19.

Department of Endoscopy, Nagoya University Hospital, Nagoya, Japan.

Background: There are a number of reports that demonstrate the high diagnostic accuracy of colon capsule endoscopy (CCE) for polyp detection. However, some colorectal polyps are missed on CCE, and the clinical factors influencing those missed polyps are still unknown.

Objective: The aim of this study was to elucidate the clinical factors related to missing colorectal polyp on CCE by using per-polyp analysis. Read More

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http://dx.doi.org/10.1159/000498942DOI Listing

Learning Effect of Diagnosing Depth of Invasion Using Non-Extension Sign in Early Gastric Cancer.

Digestion 2019 Mar 19:1-7. Epub 2019 Mar 19.

Department of Endoscopy, Fukuoka University Chikushi Hospital, Fukuoka, Japan.

Background: Determining the depth of invasion is important when considering therapeutic strategies for early gastric cancer (EGC). We determined the effects of learning the non-extension sign, that is, an index of T1b2 in EGC, on identifying its depth of invasion.

Methods: Endoscopic images of 40 EGC cases (20 showing positive non-extension sign on endoscopy as T1b2 and 20 showing negative non-extension sign on endoscopy as T1a-T1b1) were randomly displayed on PowerPoint. Read More

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http://dx.doi.org/10.1159/000498845DOI Listing

Rikkunshito Depolarizes Pacemaker Potentials of Cultured Interstitial Cells of Cajal through Ghrelin Receptors in Murine Small Intestine.

Digestion 2019 Mar 19:1-12. Epub 2019 Mar 19.

Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan, Republic of Korea,

Background: Rikkunshito has been used to treat gastrointestinal (GI) disorders. The purpose of this study was to investigate the effects of Rikkunshito, a traditional Japanese herbal medicine, on the pacemaker potentials of interstitial cells of Cajal (ICCs) from the small intestines of mice.

Methods: We isolated ICCs from the small intestines of mice, and the whole-cell patch-clamp configuration was used to record the pacemaker potentials in cultured ICCs and membrane currents. Read More

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http://dx.doi.org/10.1159/000498986DOI Listing
March 2019
2 Reads

Histological Features of Gastric Mucosa Serologically Diagnosed as Gastric Atrophy without Helicobacter pylori Infection.

Digestion 2019 Mar 14:1-10. Epub 2019 Mar 14.

Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.

Background/aims: Although gastric atrophy is primarily caused by Helicobacter pylori infection, it is unclear why patients serologically diagnosed with gastric atrophy without H. pylori infection exhibit greater atrophy. We investigated histopathological features in serologically diagnosed gastric atrophy without H. Read More

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http://dx.doi.org/10.1159/000498940DOI Listing
March 2019
1 Read

Chenodeoxycholic Acid Releases Proinflammatory Cytokines from Small Intestinal Epithelial Cells Through the Farnesoid X Receptor.

Digestion 2019 Mar 7:1-9. Epub 2019 Mar 7.

Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

Background/aims: Bile acids have recently been associated with the pathogenesis of irritable bowel syndrome (IBS). We therefore evaluated the expression of bile acid receptors in the intestinal mucosa of IBS patients as well as the effects of bile acids on small intestinal epithelial cells.

Methods: Intestinal biopsy specimens were obtained from 15 IBS patients and 15 healthy controls. Read More

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http://dx.doi.org/10.1159/000496687DOI Listing
March 2019
5 Reads

Effects of L-Menthol and Carbon Dioxide on the Adenoma Detection Rate during Colonoscopy: L-Menthol and Carbon Dioxide on Colonoscopy.

Digestion 2019 Mar 7:1-9. Epub 2019 Mar 7.

Department of Gastroenterology and Hepatology, Fukuchiyama City Hospital, Kyoto, Japan.

Background And Aims: We examined the efficacy of the combined use of L-menthol spraying (L-mentholS) as an antispasmodic agent and carbon dioxide insufflation (CO2I) on the adenoma detection rate (ADR) in a prospective, single-center trial with a 2 × 2 factorial design.

Methods: We randomly assigned 611 patients scheduled to undergo colonoscopy to 4 groups: (1) the L-mentholS + CO2I (n = 153), (2) L-mentholS + air insufflation (AI; n = 156), (3) CO2I (n = 153), and (4) AI (n = 149) groups. We used 20 mL of 0. Read More

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http://dx.doi.org/10.1159/000498941DOI Listing
March 2019
1 Read

Endoscopic Detachable Snare Ligation Improves the Treatment for Colonic Diverticular Hemorrhage.

Digestion 2019 Mar 6:1-9. Epub 2019 Mar 6.

Division of Endoscopic Center, University of Tsukuba Hospital, Tsukuba, Japan.

Background/aims: Recently, endoscopic detachable snare ligation (EDSL) has become increasingly common as treatment for colonic diverticular hemorrhage. This study aimed to evaluate the efficacy and safety of EDSL in comparison with endoscopic clipping (EC) as treatment for colonic diverticular hemorrhage.

Methods: From April 2013 to September 2017, 131 patients were treated with EDSL or EC at the Tokyo Metropolitan Bokutoh Hospital. Read More

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http://dx.doi.org/10.1159/000498847DOI Listing
March 2019
5 Reads

A Study on the Status of Proton Pump Inhibitor Prescriptions Using Diagnosis Procedure Combination Data in Japan.

Digestion 2019 Mar 6:1-8. Epub 2019 Mar 6.

Department of Internal Medicine and Gastroenterology, Saga Medical School, Saga, Japan.

Background/aims: Proton pump inhibitors (PPIs) are widely used for the management of acid-related diseases. This study aimed to clarify the status of PPI use in hospitalized patients.

Method: A retrospective observational study was performed. Read More

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http://dx.doi.org/10.1159/000498967DOI Listing

Accuracy of Different Rapid Urease Tests in Comparison with Histopathology in Patients with Endoscopic Signs of Gastritis.

Digestion 2019 Feb 28:1-7. Epub 2019 Feb 28.

Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany,

Background And Aim: According to several guidelines, both invasive and non-invasive tests can be used to detect Helicobacter pylori (H. pylori). Invasive methods include H. Read More

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http://dx.doi.org/10.1159/000497810DOI Listing
February 2019
3 Reads

Comparisons of the Mucosal Healing Process between Flat and Protruded Type after Endoscopic Submucosal Dissection for Gastric Neoplasms.

Digestion 2019 22;99(3):219-226. Epub 2019 Feb 22.

Department of Gastroenterology, Ajou University School of Medicine, Suwon, Republic of Korea.

Background/aims: The mucosal healing process after endoscopic submucosal dissection (ESD) is mostly scarring change (flat type), but a protruded lesion is occasionally found. We investigated the factors influencing the mucosal healing process, such as the flat and protruded types.

Methods: A total of 2,096 ESD cases were performed from February 2005 to December 2013, and 1,757 underwent follow-up endoscopy after 3 months to check the healing type of the ulceration. Read More

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http://dx.doi.org/10.1159/000491592DOI Listing
February 2019

Long-Term Outcomes after Surgical Resection for Synchronous or Metachronous Hepatic and Pulmonary Colorectal Cancer Metastases.

Digestion 2019 Feb 15:1-12. Epub 2019 Feb 15.

Thoracic Surgery Unit, Azienda Unità Sanitaria Locale/IRCCS of Reggio Emilia, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.

Background/aims: At present, benefits of surgical resection and appropriate selection criteria in patients affected by both hepatic and pulmonary metastases of colorectal cancer (CRC) are under discussion. Our analysis focused on a surgical series of such patients and our final aim consisted in identifying potential prognostic factors.

Methods: Eighty-five patients undergoing resection of both hepatic and pulmonary metastases at 2 Healthcare Institutions from January 1993 to June 2015 were retrospectively reviewed as concerned clinical information, surgical notes and pathological features. Read More

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http://dx.doi.org/10.1159/000497223DOI Listing
February 2019
2 Reads

Loss of RUNX3 Immunoreactivity in Non-Neoplastic Rectal Mucosa May Predict the Occurrence of Ulcerative Colitis-Associated Colorectal Cancer.

Digestion 2019 Feb 14:1-9. Epub 2019 Feb 14.

Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.

Background/aims: Runt-related transcription factor (RUNX) 3 is a tumor suppressor whose expression is reduced in non-neoplastic rectal mucosa of patients with ulcerative colitis (UC) with coexisting colitis-associated cancer (CAC). We aimed to evaluate RUNX3 utility as a predictive marker for CAC using immunohistochemistry (IHC) for non-neoplastic UC mucosa.

Methods: We retrospectively compared the RUNX3 expression detected by IHC between non-neoplastic rectal biopsy specimens from 20 cases with invasive cancer (CAC group) and 20 cases selected from 138 patients without CAC (non-CAC group) that were treated during the same period (2006-2017) and were matched for sex, duration, extension, and age. Read More

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https://www.karger.com/Article/FullText/497272
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http://dx.doi.org/10.1159/000497272DOI Listing
February 2019
1 Read

A Nondilated Main Pancreatic Duct Predicts Type 2 Autoimmune Pancreatitis: Comparative Study of Resected Pancreatic Head Masses.

Digestion 2019 Feb 13:1-7. Epub 2019 Feb 13.

Department of Pathology, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico.

Background: Chronic pancreatitis (CP), pancreatic cancer (PCa), and autoimmune pancreatitis (AIP) often present as a pancreatic mass. Accurate diagnosis is not always possible; up to 8% of surgical procedures are performed in benign pancreatic masses presumed to be malignant.

Objectives: We aimed to compare clinical and imaging characteristics of resected focal type 2 AIP, CP, and PCa and identify factors that could improve preoperative differential diagnosis. Read More

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http://dx.doi.org/10.1159/000497140DOI Listing
February 2019
2 Reads

Metabolic Endoscopy: Development and Perspectives.

Authors:
Dirk Raddatz

Digestion 2019 Feb 7:1-5. Epub 2019 Feb 7.

Department of Gastroenterology and Endocrinology, University Medical Center Goettingen, Goettingen, Germany,

Background: Obesity and its metabolic sequelae are among the most serious challenges faced by health systems today and they are expected to pose a serious threat in the future as well. Therapy ranges from lifestyle modification to drug treatment to surgery. Metabolic endoscopy (ME) might close the gap between invasive "metabolic" surgery and conservative, less effective treatment. Read More

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https://www.karger.com/Article/FullText/494428
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http://dx.doi.org/10.1159/000494428DOI Listing
February 2019
9 Reads

Mucosa-Associated Microbiota in the Gastrointestinal Tract of Healthy Japanese Subjects.

Digestion 2019 Feb 5:1-14. Epub 2019 Feb 5.

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Background: The importance of microbiota infiltrating the gut mucus layer has been reported in the pathogenesis of various gastrointestinal and systemic diseases. However, little is known about the mucosa-associated microbiota (MAM) in healthy subjects. The present study aimed to clarify the characteristics of the gastrointestinal MAM from the oral cavity to the rectum in healthy Japanese subjects. Read More

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http://dx.doi.org/10.1159/000496102DOI Listing
February 2019
2 Reads

Predictive Factors for Rebleeding after Negative Capsule Endoscopy among Patients with Overt Obscure Gastrointestinal Bleeding.

Digestion 2019 Feb 1:1-8. Epub 2019 Feb 1.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan,

Background: Although capsule endoscopy (CE) is useful to evaluate obscure gastrointestinal bleeding (OGIB), CE does not always identify the responsible lesions in patients with overt OGIB.

Objectives: To identify factors predictive of rebleeding after negative CE in patients with overt OGIB.

Methods: We retrospectively analyzed the clinical data of 221 patients who underwent CE for overt OGIB. Read More

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https://www.karger.com/Article/FullText/496826
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http://dx.doi.org/10.1159/000496826DOI Listing
February 2019
7 Reads

MR Defecography in Assessing Functional Defecation Disorder: Diagnostic Value of the Defecation Phase in Detection of Dyssynergic Defecation and Pelvic Floor Prolapse in Females.

Digestion 2019 Jan 29:1-8. Epub 2019 Jan 29.

Department of Colon and Rectum Surgery, Beijing Chaoyang Hospital, Affiliated to Capital Medical University, Beijing, China.

Objective: Dyssynergic defecation (DD) and pelvic floor prolapse often coexist in female functional defecation disorder. A retrospective study was performed to evaluate the ability of dynamic MR sequences with the straining and defecation phase to detect paradoxical puborectalis contraction and occult multiple-compartments disorders.

Methods: Fifty-three females clinically diagnosed with DD underwent magnetic resonance defecography. Read More

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https://www.karger.com/Article/FullText/494249
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http://dx.doi.org/10.1159/000494249DOI Listing
January 2019
4 Reads
2.032 Impact Factor

Long-Term Prognosis of Patients with Obscure Gastrointestinal Bleeding: A Retrospective Cohort Study.

Digestion 2019 Jan 11:1-8. Epub 2019 Jan 11.

Department of Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Aims: We evaluated the long-term prognosis of patients with obscure gastrointestinal bleeding (OGIB) who underwent capsule endoscopy (CE).

Methods: In our hospital, 429 patients underwent CE between November 2007 and March 2012. Among them, 259 patients underwent CE as the first examination for OGIB and were then followed at 77 clinics and hospitals. Read More

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http://dx.doi.org/10.1159/000493854DOI Listing
January 2019
15 Reads

Characteristics and Predictive Factor of Helicobacter pylori-Associated Functional Dyspepsia in Japanese Patients.

Digestion 2019 Jan 10:1-9. Epub 2019 Jan 10.

Department of Gastroenterology Aichi Medical University, Nagakute, Japan.

Background/aim: Helicobacter pylori (HP) eradication therapy was first recommended as pharmacotherapy for functional dyspepsia (FD). However, the mechanism and effect of eradication on FD symptom improvement have not been fully investigated. This study aimed to investigate the pathology of patients with HP-associated FD, and predictive factors for HP-associated FD. Read More

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https://www.karger.com/Article/FullText/496101
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http://dx.doi.org/10.1159/000496101DOI Listing
January 2019
9 Reads

Clinical Course of Chronic Pancreatitis in Elderly Patients.

Digestion 2019 Jan 10:1-8. Epub 2019 Jan 10.

Department of Medicine II, University Medical Center Mannheim, Medical Faculty at Mannheim, University of Heidelberg, Mannheim, Germany,

Background: Several guidelines recommend the risk-adapted monitoring of patients with chronic pancreatitis (CP). However, dedicated risk stratification is widely missing in CP. Elderly-CP (disease onset with 60 or more years of age) may represent a subgroup of CP subjects with a distinct course of disease. Read More

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https://www.karger.com/Article/FullText/494349
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http://dx.doi.org/10.1159/000494349DOI Listing
January 2019
15 Reads

Guidelines for Colonic Diverticular Bleeding and Colonic Diverticulitis: Japan Gastroenterological Association.

Digestion 2019 9;99 Suppl 1:1-26. Epub 2019 Jan 9.

Japanese Gastroenterological Association, Tokyo, Japan.

Colonic diverticular disease has been increasing in prevalence in Japan due to the rapidly aging population. Colonic diverticular bleeding can result in hemorrhagic shock requiring blood transfusion, and it carries a high risk of recurrence within 1 year. Colonic diverticulitis can cause abscess, fistula formation, and perforation of the colon that may require surgery, and it often recurs. Read More

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https://www.karger.com/Article/FullText/495282
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http://dx.doi.org/10.1159/000495282DOI Listing
April 2019
26 Reads

Predictors for Complicated Disease Course after Stepping Down from Combination to Antitumor Necrosis Factor Alpha Monotherapy in Children with Inflammatory Bowel Disease.

Digestion 2019 Jan 9:1-8. Epub 2019 Jan 9.

Pediatric Gastroenterology Unit, "Dana-Dwek" Children's Hospital, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel,

Objective: Combinations of antitumor necrosis factor alpha (TNFα) and immunomodulators may be indicated in high-risk inflammatory bowel disease patients. Our aims were to compare disease course between children that did and did not step down to anti-TNFα monotherapy and to define risk factors for complicated disease course after stepping down.

Methods: A retrospective review of the medical records of consecutive children who were treated with combination therapy. Read More

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https://www.karger.com/Article/FullText/496273
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http://dx.doi.org/10.1159/000496273DOI Listing
January 2019
8 Reads

Oral Litholysis in Patients with Chronic Calcific Pancreatitis Unresponsive to or Ineligible for Extracorporeal Shock Wave Lithotripsy and Endoscopic Therapy.

Digestion 2019 Jan 3:1-9. Epub 2019 Jan 3.

Division of General Medicine, Aichi Medical University, Nagakute, Japan.

Background/aims: Our study aimed to evaluate the effect of oral litholysis in patients with chronic calcific pancreatitis (CCP) unresponsive to or ineligible for extracorporeal shock wave lithotripsy (ESWL) and endoscopic therapy.

Methods: Trimethadione, an antiepileptic agent, was administered orally at a dose of 0.6-0. Read More

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http://dx.doi.org/10.1159/000495608DOI Listing
January 2019
3 Reads

A Novel Predictive Nomogram for Early Endoscopic Recurrence after Intestinal Resection for Crohn's Disease.

Digestion 2019 Jan 2:1-8. Epub 2019 Jan 2.

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan,

Background/aims: Endoscopic recurrence (ER) after intestinal resection for Crohn's disease (CD) precedes the clinical recurrence, and the severity of ER correlates with the severity of the subsequent clinical recurrence. This study aimed to identify risk factors related to early ER after intestinal resection for CD and to create a prediction model.

Methods: The patients who underwent intestinal resection for CD between April 2008 and April 2017 and took endoscopic evaluation between 6 and 12 months after surgery were retrospectively analyzed. Read More

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http://dx.doi.org/10.1159/000495981DOI Listing
January 2019
2 Reads

pH-Dependent 5-Aminosalicylates Releasing Preparations Do Not Affect Thiopurine Metabolism.

Digestion 2019 Jan 2:1-9. Epub 2019 Jan 2.

Department of Medicine, Shiga University of Medical Science, Otsu, Japan.

Background/aims: Thiopurines are key drugs in maintenance therapy for treating inflammatory bowel disease (IBD). Time-dependent 5-aminosalicylates (5-ASA) releasing preparations (time-dependent 5-ASA) increase 6-thioguanine nucleotide (6-TGN), an active metabolite of thiopurines. However, the effects of pH-dependent 5-ASA releasing preparations (pH-dependent 5-ASA) on thiopurine metabolism were not reported. Read More

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https://www.karger.com/Article/FullText/495690
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http://dx.doi.org/10.1159/000495690DOI Listing
January 2019
26 Reads

Minimally Invasive Function-Preserving Gastrectomy with Sentinel Node Biopsy for Early Gastric Cancer.

Digestion 2019 14;99(1):14-20. Epub 2018 Dec 14.

Department of Surgery, Keio University School of Medicine, Tokyo, Japan.

Background: Recently, minimally invasive approaches such as endoscopic treatment or laparoscopic gastrectomy for early gastric cancer have made rapid progress. However, the extent of gastrectomy and lymphadenectomy in laparoscopic surgery is radical, similar to that of open gastrectomy for patients with early gastric cancer diagnosed as not indicated for endoscopic treatment. Since it is well known that lymph node metastasis is an important prognostic factor, the standard procedure of gastrectomy with radical lymph node dissection has been performed for the purpose of curative resection. Read More

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https://www.karger.com/Article/FullText/494407
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http://dx.doi.org/10.1159/000494407DOI Listing
April 2019
11 Reads

Irritable Bowel Syndrome-Like Symptoms in Ulcerative Colitis Patients in Clinical Remission: Association with Residual Colonic Inflammation.

Digestion 2019 14;99(1):46-51. Epub 2018 Dec 14.

Department of Internal Medicine II, Shimane University Faculty of Medicine, Izumo, Japan.

Ulcerative colitis (UC) patients in clinical remission often experience irritable bowel syndrome (IBS)-like symptoms. The prevalence rate of UC patients meeting the definition of IBS, such as shown by the Rome criteria, is significantly higher in those without ongoing clinical activity as compared to healthy controls. Several studies have investigated residual low-grade inflammation found in colonic mucosa of quiescent UC patients and its association with development of IBS-like symptoms. Read More

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http://dx.doi.org/10.1159/000494412DOI Listing
April 2019
6 Reads

Recurrence Patterns and Outcomes of Salvage Surgery in Cases of Non-Curative Endoscopic Submucosal Dissection without Additional Radical Surgery for Early Gastric Cancer.

Digestion 2019 14;99(1):52-58. Epub 2018 Dec 14.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background/aims: The outcomes of salvage surgery for recurrence after non-curative endoscopic submucosal dissection (ESD) without additional radical surgery for early gastric cancer (EGC) remain unclear. We determined the recurrence patterns and outcomes of salvage surgery in such cases using data from a multicenter, retrospective study.

Methods: Of 15,785 patients who underwent ESD for EGC at 19 participating institutions between January 2000 and August 2011, 1,969 failed to meet the current curative criteria after ESD. Read More

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https://www.karger.com/Article/FullText/494413
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http://dx.doi.org/10.1159/000494413DOI Listing
April 2019
25 Reads

Current Status and Challenges of Endoscopic Treatments for Duodenal Tumors.

Digestion 2019 14;99(1):21-26. Epub 2018 Dec 14.

Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Tokyo, Japan,

Background: Superficial tumors of the duodenum, other than ampullary tumors, have been traditionally considered rare. However, reports of this kind of tumor have increased in recent times, and the demand for minimally invasive treatments have also increasing.

Summary: Adenomas and intramucosal carcinomas are target lesions for treatment. Read More

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http://dx.doi.org/10.1159/000494408DOI Listing
April 2019
12 Reads

Low Skeletal Muscle Mass before Salvage-Line Chemotherapy Is a Poor Prognostic Factor in Patients with Refractory Metastatic Colorectal Cancer.

Digestion 2019 14;99(1):79-85. Epub 2018 Dec 14.

Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan,

Background: Regorafenib and TAS-102 are standard salvage-line treatment options for patients with chemorefractory metastatic colorectal cancer (mCRC). We aimed to evaluate the prognostic significance of skeletal muscle mass in mCRC patients receiving these salvage-line therapies.

Methods: We conducted a retrospective analysis of 52 patients with mCRC who received regorafenib or TAS-102 as salvage-line treatment. Read More

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http://dx.doi.org/10.1159/000494417DOI Listing
April 2019
9 Reads

The Incidence and Risk Factors of Venous Thromboembolism in Patients with Inflammatory Bowel Disease: A Prospective Multicenter Cohort Study.

Digestion 2018 Dec 14:1-9. Epub 2018 Dec 14.

Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.

Background: Venous thromboembolism (VTE) has been shown to be more frequent in inflammatory bowel disease (IBD) than in the general population in Western studies. However, the actual state of VTE in Asian IBD remains poorly understood.

Aims: To reveal the incidence of VTE in IBD patients in Japan. Read More

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http://dx.doi.org/10.1159/000495289DOI Listing
December 2018
4 Reads

Gastric Cancer with Submucosal Invasion after Successful Helicobacter pylori Eradication: A Propensity Score-Matched Analysis of Patients with Annual Patient Endoscopic Survey.

Digestion 2019 14;99(1):59-65. Epub 2018 Dec 14.

Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan.

Background And Aim: The incidence of gastric cancer occurring after successful Helicobacter pylori eradication has been increasing. We aimed to clarify the influence of eradication therapy on the ability to diagnose early gastric cancer after successful H. pylori eradication in patients who underwent annual endoscopic screening. Read More

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http://dx.doi.org/10.1159/000494414DOI Listing
April 2019
2 Reads

Liquid Biopsy for the Management of Patients with Colorectal Cancer.

Digestion 2019 14;99(1):39-45. Epub 2018 Dec 14.

Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan.

Background: Liquid biopsy is a collective term that refers to the analysis of tumor-derived biomarkers isolated from biological fluids of cancer patients. Recently, many authors reported the usefulness of liquid biopsy for the management of malignancy. Summary and Key Messages: The peripheral blood of cancer patients is a pool of cells and/or cell products derived from the primary or metastatic tumor, including circulating tumor cells (CTCs), circulating free (cf) DNA or RNA, and exosomes containing proteins, nucleic acids, and lipids. Read More

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https://www.karger.com/Article/FullText/494411
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http://dx.doi.org/10.1159/000494411DOI Listing
April 2019
5 Reads

Effects of Early Initiation of Solid Versus Liquid Diet after Endoscopic Submucosal Dissection on Quality of Life and Postoperative Outcomes: A Prospective Pilot Randomized Controlled Trial.

Digestion 2018 Dec 14:1-10. Epub 2018 Dec 14.

Department of Gastroenterology, Asahi General Hospital, Chiba, Japan.

Background/aims: Feeding recommendations after endoscopic submucosal dissection (ESD) for gastric neoplasms are not established and based on clinical experience.

Methods: This was a prospective pilot randomized controlled trial. Patients undergoing ESD for gastric neoplasms were randomly assigned to solid (n = 50) or liquid diet (n = 50) groups. Read More

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http://dx.doi.org/10.1159/000494490DOI Listing
December 2018
8 Reads

Pilot Study Indicates Helicobacter pylori Infection May Induce Small Intestinal Mucosal Injury.

Digestion 2019 14;99(1):66-71. Epub 2018 Dec 14.

Department of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Tokyo, Japan.

Background And Aim: Helicobacter pylori infection is a primary cause of gastroduodenal ulcers. To investigate whether there is an association between H. pylori infection and small intestinal mucosal injury. Read More

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http://dx.doi.org/10.1159/000494415DOI Listing
April 2019
5 Reads

The 14th Annual Meeting of the Japanese Gastroenterological Association.

Authors:

Digestion 2019 14;99(1). Epub 2018 Dec 14.

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http://dx.doi.org/10.1159/000494405DOI Listing
December 2018
1 Read

Recent Incidence Trend of Surgically Resected Esophagogastric Junction Adenocarcinoma and Microsatellite Instability Status in Japanese Patients.

Digestion 2019 14;99(1):6-13. Epub 2018 Dec 14.

Department of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation of Cancer Research, Tokyo, Japan.

Background: The incidence trend of esophagogastric junction (EGJ) adenocarcinoma in Japan has not been sufficiently investigated. Little is known about the microsatellite instability (MSI) status of this tumor.

Summary: Previously published studies analyzing the trend of EGJ adenocarcinoma in Japan were reviewed. Read More

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http://dx.doi.org/10.1159/000494406DOI Listing
April 2019
2 Reads

Questionnaire-Based Survey on Management of Ulcerative Colitis-Associated Cancer in East Asian Countries.

Digestion 2019 14;99(1):86-94. Epub 2018 Dec 14.

Sino United Health Clinic, Gopher Medical Center, Rui Jing Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background/aims: To elucidate the current management of ulcerative colitis (UC)-associated cancer, a questionnaire-based survey was conducted to gather current opinions on colitis-associated cancer in different East Asian countries.

Methods: The questionnaire, based on physicians, contains 9 questions focused on UC management and cancer surveillance. In addition, the questionnaire based on neoplastic cases, which contains 17 questions, was collected and analyzed. Read More

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http://dx.doi.org/10.1159/000494419DOI Listing
April 2019
2 Reads