4,452 results match your criteria Digestion[Journal]


Loss of RUNX3 Immunoreactivity in Non-Neoplastic Rectal Mucosa May Predict the Occurrence of Ulcerative Colitis-Associated Colorectal Cancer.

Digestion 2019 Feb 14:1-9. Epub 2019 Feb 14.

Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.

Background/aims: Runt-related transcription factor (RUNX) 3 is a tumor suppressor whose expression is reduced in non-neoplastic rectal mucosa of patients with ulcerative colitis (UC) with coexisting colitis-associated cancer (CAC). We aimed to evaluate RUNX3 utility as a predictive marker for CAC using immunohistochemistry (IHC) for non-neoplastic UC mucosa.

Methods: We retrospectively compared the RUNX3 expression detected by IHC between non-neoplastic rectal biopsy specimens from 20 cases with invasive cancer (CAC group) and 20 cases selected from 138 patients without CAC (non-CAC group) that were treated during the same period (2006-2017) and were matched for sex, duration, extension, and age. Read More

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http://dx.doi.org/10.1159/000497272DOI Listing
February 2019

A Nondilated Main Pancreatic Duct Predicts Type 2 Autoimmune Pancreatitis: Comparative Study of Resected Pancreatic Head Masses.

Digestion 2019 Feb 13:1-7. Epub 2019 Feb 13.

Department of Pathology, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico.

Background: Chronic pancreatitis (CP), pancreatic cancer (PCa), and autoimmune pancreatitis (AIP) often present as a pancreatic mass. Accurate diagnosis is not always possible; up to 8% of surgical procedures are performed in benign pancreatic masses presumed to be malignant.

Objectives: We aimed to compare clinical and imaging characteristics of resected focal type 2 AIP, CP, and PCa and identify factors that could improve preoperative differential diagnosis. Read More

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http://dx.doi.org/10.1159/000497140DOI Listing
February 2019

Metabolic Endoscopy: Development and Perspectives.

Authors:
Dirk Raddatz

Digestion 2019 Feb 7:1-5. Epub 2019 Feb 7.

Department of Gastroenterology and Endocrinology, University Medical Center Goettingen, Goettingen,

Background: Obesity and its metabolic sequelae are among the most serious challenges faced by health systems today and they are expected to pose a serious threat in the future as well. Therapy ranges from lifestyle modification to drug treatment to surgery. Metabolic endoscopy (ME) might close the gap between invasive "metabolic" surgery and conservative, less effective treatment. Read More

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https://www.karger.com/Article/FullText/494428
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http://dx.doi.org/10.1159/000494428DOI Listing
February 2019
2 Reads

Mucosa-Associated Microbiota in the Gastrointestinal Tract of Healthy Japanese Subjects.

Digestion 2019 Feb 5:1-14. Epub 2019 Feb 5.

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Background: The importance of microbiota infiltrating the gut mucus layer has been reported in the pathogenesis of various gastrointestinal and systemic diseases. However, little is known about the mucosa-associated microbiota (MAM) in healthy subjects. The present study aimed to clarify the characteristics of the gastrointestinal MAM from the oral cavity to the rectum in healthy Japanese subjects. Read More

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http://dx.doi.org/10.1159/000496102DOI Listing
February 2019

Predictive Factors for Rebleeding after Negative Capsule Endoscopy among Patients with Overt Obscure Gastrointestinal Bleeding.

Digestion 2019 Feb 1:1-8. Epub 2019 Feb 1.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka,

Background: Although capsule endoscopy (CE) is useful to evaluate obscure gastrointestinal bleeding (OGIB), CE does not always identify the responsible lesions in patients with overt OGIB.

Objectives: To identify factors predictive of rebleeding after negative CE in patients with overt OGIB.

Methods: We retrospectively analyzed the clinical data of 221 patients who underwent CE for overt OGIB. Read More

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https://www.karger.com/Article/FullText/496826
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http://dx.doi.org/10.1159/000496826DOI Listing
February 2019
2 Reads

MR Defecography in Assessing Functional Defecation Disorder: Diagnostic Value of the Defecation Phase in Detection of Dyssynergic Defecation and Pelvic Floor Prolapse in Females.

Digestion 2019 Jan 29:1-8. Epub 2019 Jan 29.

Department of Colon and Rectum Surgery, Beijing Chaoyang Hospital, Affiliated to Capital Medical University, Beijing, China.

Objective: Dyssynergic defecation (DD) and pelvic floor prolapse often coexist in female functional defecation disorder. A retrospective study was performed to evaluate the ability of dynamic MR sequences with the straining and defecation phase to detect paradoxical puborectalis contraction and occult multiple-compartments disorders.

Methods: Fifty-three females clinically diagnosed with DD underwent magnetic resonance defecography. Read More

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https://www.karger.com/Article/FullText/494249
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http://dx.doi.org/10.1159/000494249DOI Listing
January 2019
3 Reads
2.032 Impact Factor

Long-Term Prognosis of Patients with Obscure Gastrointestinal Bleeding: A Retrospective Cohort Study.

Digestion 2019 Jan 11:1-8. Epub 2019 Jan 11.

Department of Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Aims: We evaluated the long-term prognosis of patients with obscure gastrointestinal bleeding (OGIB) who underwent capsule endoscopy (CE).

Methods: In our hospital, 429 patients underwent CE between November 2007 and March 2012. Among them, 259 patients underwent CE as the first examination for OGIB and were then followed at 77 clinics and hospitals. Read More

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http://dx.doi.org/10.1159/000493854DOI Listing
January 2019
7 Reads

Characteristics and Predictive Factor of Helicobacter pylori-Associated Functional Dyspepsia in Japanese Patients.

Digestion 2019 Jan 10:1-9. Epub 2019 Jan 10.

Department of Gastroenterology Aichi Medical University, Nagakute, Japan.

Background/aim: Helicobacter pylori (HP) eradication therapy was first recommended as pharmacotherapy for functional dyspepsia (FD). However, the mechanism and effect of eradication on FD symptom improvement have not been fully investigated. This study aimed to investigate the pathology of patients with HP-associated FD, and predictive factors for HP-associated FD. Read More

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https://www.karger.com/Article/FullText/496101
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http://dx.doi.org/10.1159/000496101DOI Listing
January 2019
5 Reads

Clinical Course of Chronic Pancreatitis in Elderly Patients.

Digestion 2019 Jan 10:1-8. Epub 2019 Jan 10.

Department of Medicine II, University Medical Center Mannheim, Medical Faculty at Mannheim, University of Heidelberg, Mannheim,

Background: Several guidelines recommend the risk-adapted monitoring of patients with chronic pancreatitis (CP). However, dedicated risk stratification is widely missing in CP. Elderly-CP (disease onset with 60 or more years of age) may represent a subgroup of CP subjects with a distinct course of disease. Read More

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https://www.karger.com/Article/FullText/494349
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http://dx.doi.org/10.1159/000494349DOI Listing
January 2019
9 Reads

Guidelines for Colonic Diverticular Bleeding and Colonic Diverticulitis: Japan Gastroenterological Association.

Digestion 2019 9;99 Suppl 1:1-26. Epub 2019 Jan 9.

Japanese Gastroenterological Association, Tokyo, Japan.

Colonic diverticular disease has been increasing in prevalence in Japan due to the rapidly aging population. Colonic diverticular bleeding can result in hemorrhagic shock requiring blood transfusion, and it carries a high risk of recurrence within 1 year. Colonic diverticulitis can cause abscess, fistula formation, and perforation of the colon that may require surgery, and it often recurs. Read More

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https://www.karger.com/Article/FullText/495282
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http://dx.doi.org/10.1159/000495282DOI Listing
January 2019
20 Reads

Predictors for Complicated Disease Course after Stepping Down from Combination to Antitumor Necrosis Factor Alpha Monotherapy in Children with Inflammatory Bowel Disease.

Digestion 2019 Jan 9:1-8. Epub 2019 Jan 9.

Objective: Combinations of antitumor necrosis factor alpha (TNFα) and immunomodulators may be indicated in high-risk inflammatory bowel disease patients. Our aims were to compare disease course between children that did and did not step down to anti-TNFα monotherapy and to define risk factors for complicated disease course after stepping down.

Methods: A retrospective review of the medical records of consecutive children who were treated with combination therapy. Read More

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https://www.karger.com/Article/FullText/496273
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http://dx.doi.org/10.1159/000496273DOI Listing
January 2019
5 Reads

Oral Litholysis in Patients with Chronic Calcific Pancreatitis Unresponsive to or Ineligible for Extracorporeal Shock Wave Lithotripsy and Endoscopic Therapy.

Digestion 2019 Jan 3:1-9. Epub 2019 Jan 3.

Division of General Medicine, Aichi Medical University, Nagakute, Japan.

Background/aims: Our study aimed to evaluate the effect of oral litholysis in patients with chronic calcific pancreatitis (CCP) unresponsive to or ineligible for extracorporeal shock wave lithotripsy (ESWL) and endoscopic therapy.

Methods: Trimethadione, an antiepileptic agent, was administered orally at a dose of 0.6-0. Read More

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http://dx.doi.org/10.1159/000495608DOI Listing
January 2019
2 Reads

A Novel Predictive Nomogram for Early Endoscopic Recurrence after Intestinal Resection for Crohn's Disease.

Digestion 2019 Jan 2:1-8. Epub 2019 Jan 2.

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka,

Background/aims: Endoscopic recurrence (ER) after intestinal resection for Crohn's disease (CD) precedes the clinical recurrence, and the severity of ER correlates with the severity of the subsequent clinical recurrence. This study aimed to identify risk factors related to early ER after intestinal resection for CD and to create a prediction model.

Methods: The patients who underwent intestinal resection for CD between April 2008 and April 2017 and took endoscopic evaluation between 6 and 12 months after surgery were retrospectively analyzed. Read More

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http://dx.doi.org/10.1159/000495981DOI Listing
January 2019
1 Read

pH-Dependent 5-Aminosalicylates Releasing Preparations Do Not Affect Thiopurine Metabolism.

Digestion 2019 Jan 2:1-9. Epub 2019 Jan 2.

Department of Medicine, Shiga University of Medical Science, Otsu, Japan.

Background/aims: Thiopurines are key drugs in maintenance therapy for treating inflammatory bowel disease (IBD). Time-dependent 5-aminosalicylates (5-ASA) releasing preparations (time-dependent 5-ASA) increase 6-thioguanine nucleotide (6-TGN), an active metabolite of thiopurines. However, the effects of pH-dependent 5-ASA releasing preparations (pH-dependent 5-ASA) on thiopurine metabolism were not reported. Read More

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https://www.karger.com/Article/FullText/495690
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http://dx.doi.org/10.1159/000495690DOI Listing
January 2019
17 Reads

Minimally Invasive Function-Preserving Gastrectomy with Sentinel Node Biopsy for Early Gastric Cancer.

Digestion 2019 14;99(1):14-20. Epub 2018 Dec 14.

Department of Surgery, Keio University School of Medicine, Tokyo, Japan.

Background: Recently, minimally invasive approaches such as endoscopic treatment or laparoscopic gastrectomy for early gastric cancer have made rapid progress. However, the extent of gastrectomy and lymphadenectomy in laparoscopic surgery is radical, similar to that of open gastrectomy for patients with early gastric cancer diagnosed as not indicated for endoscopic treatment. Since it is well known that lymph node metastasis is an important prognostic factor, the standard procedure of gastrectomy with radical lymph node dissection has been performed for the purpose of curative resection. Read More

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https://www.karger.com/Article/FullText/494407
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http://dx.doi.org/10.1159/000494407DOI Listing
December 2018
6 Reads

Irritable Bowel Syndrome-Like Symptoms in Ulcerative Colitis Patients in Clinical Remission: Association with Residual Colonic Inflammation.

Digestion 2019 14;99(1):46-51. Epub 2018 Dec 14.

Department of Internal Medicine II, Shimane University Faculty of Medicine, Izumo, Japan.

Ulcerative colitis (UC) patients in clinical remission often experience irritable bowel syndrome (IBS)-like symptoms. The prevalence rate of UC patients meeting the definition of IBS, such as shown by the Rome criteria, is significantly higher in those without ongoing clinical activity as compared to healthy controls. Several studies have investigated residual low-grade inflammation found in colonic mucosa of quiescent UC patients and its association with development of IBS-like symptoms. Read More

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http://dx.doi.org/10.1159/000494412DOI Listing
December 2018
2 Reads

Recurrence Patterns and Outcomes of Salvage Surgery in Cases of Non-Curative Endoscopic Submucosal Dissection without Additional Radical Surgery for Early Gastric Cancer.

Digestion 2019 14;99(1):52-58. Epub 2018 Dec 14.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background/aims: The outcomes of salvage surgery for recurrence after non-curative endoscopic submucosal dissection (ESD) without additional radical surgery for early gastric cancer (EGC) remain unclear. We determined the recurrence patterns and outcomes of salvage surgery in such cases using data from a multicenter, retrospective study.

Methods: Of 15,785 patients who underwent ESD for EGC at 19 participating institutions between January 2000 and August 2011, 1,969 failed to meet the current curative criteria after ESD. Read More

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https://www.karger.com/Article/FullText/494413
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http://dx.doi.org/10.1159/000494413DOI Listing
December 2018
16 Reads

Current Status and Challenges of Endoscopic Treatments for Duodenal Tumors.

Digestion 2019 14;99(1):21-26. Epub 2018 Dec 14.

Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Tokyo,

Background: Superficial tumors of the duodenum, other than ampullary tumors, have been traditionally considered rare. However, reports of this kind of tumor have increased in recent times, and the demand for minimally invasive treatments have also increasing.

Summary: Adenomas and intramucosal carcinomas are target lesions for treatment. Read More

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http://dx.doi.org/10.1159/000494408DOI Listing
December 2018
7 Reads

Low Skeletal Muscle Mass before Salvage-Line Chemotherapy Is a Poor Prognostic Factor in Patients with Refractory Metastatic Colorectal Cancer.

Digestion 2019 14;99(1):79-85. Epub 2018 Dec 14.

Background: Regorafenib and TAS-102 are standard salvage-line treatment options for patients with chemorefractory metastatic colorectal cancer (mCRC). We aimed to evaluate the prognostic significance of skeletal muscle mass in mCRC patients receiving these salvage-line therapies.

Methods: We conducted a retrospective analysis of 52 patients with mCRC who received regorafenib or TAS-102 as salvage-line treatment. Read More

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http://dx.doi.org/10.1159/000494417DOI Listing
December 2018
5 Reads

The Incidence and Risk Factors of Venous Thromboembolism in Patients with Inflammatory Bowel Disease: A Prospective Multicenter Cohort Study.

Digestion 2018 Dec 14:1-9. Epub 2018 Dec 14.

Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.

Background: Venous thromboembolism (VTE) has been shown to be more frequent in inflammatory bowel disease (IBD) than in the general population in Western studies. However, the actual state of VTE in Asian IBD remains poorly understood.

Aims: To reveal the incidence of VTE in IBD patients in Japan. Read More

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http://dx.doi.org/10.1159/000495289DOI Listing
December 2018
3 Reads

Gastric Cancer with Submucosal Invasion after Successful Helicobacter pylori Eradication: A Propensity Score-Matched Analysis of Patients with Annual Patient Endoscopic Survey.

Digestion 2019 14;99(1):59-65. Epub 2018 Dec 14.

Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan.

Background And Aim: The incidence of gastric cancer occurring after successful Helicobacter pylori eradication has been increasing. We aimed to clarify the influence of eradication therapy on the ability to diagnose early gastric cancer after successful H. pylori eradication in patients who underwent annual endoscopic screening. Read More

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http://dx.doi.org/10.1159/000494414DOI Listing
December 2018
2 Reads

Liquid Biopsy for the Management of Patients with Colorectal Cancer.

Digestion 2019 14;99(1):39-45. Epub 2018 Dec 14.

Background: Liquid biopsy is a collective term that refers to the analysis of tumor-derived biomarkers isolated from biological fluids of cancer patients. Recently, many authors reported the usefulness of liquid biopsy for the management of malignancy. Summary and Key Messages: The peripheral blood of cancer patients is a pool of cells and/or cell products derived from the primary or metastatic tumor, including circulating tumor cells (CTCs), circulating free (cf) DNA or RNA, and exosomes containing proteins, nucleic acids, and lipids. Read More

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https://www.karger.com/Article/FullText/494411
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http://dx.doi.org/10.1159/000494411DOI Listing
December 2018
4 Reads

Effects of Early Initiation of Solid Versus Liquid Diet after Endoscopic Submucosal Dissection on Quality of Life and Postoperative Outcomes: A Prospective Pilot Randomized Controlled Trial.

Digestion 2018 Dec 14:1-10. Epub 2018 Dec 14.

Department of Gastroenterology, Asahi General Hospital, Chiba, Japan.

Background/aims: Feeding recommendations after endoscopic submucosal dissection (ESD) for gastric neoplasms are not established and based on clinical experience.

Methods: This was a prospective pilot randomized controlled trial. Patients undergoing ESD for gastric neoplasms were randomly assigned to solid (n = 50) or liquid diet (n = 50) groups. Read More

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http://dx.doi.org/10.1159/000494490DOI Listing
December 2018
2 Reads

Pilot Study Indicates Helicobacter pylori Infection May Induce Small Intestinal Mucosal Injury.

Digestion 2019 14;99(1):66-71. Epub 2018 Dec 14.

Background And Aim: Helicobacter pylori infection is a primary cause of gastroduodenal ulcers. To investigate whether there is an association between H. pylori infection and small intestinal mucosal injury. Read More

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http://dx.doi.org/10.1159/000494415DOI Listing
December 2018
4 Reads

The 14th Annual Meeting of the Japanese Gastroenterological Association.

Authors:

Digestion 2019 14;99(1). Epub 2018 Dec 14.

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http://dx.doi.org/10.1159/000494405DOI Listing
December 2018
1 Read

Recent Incidence Trend of Surgically Resected Esophagogastric Junction Adenocarcinoma and Microsatellite Instability Status in Japanese Patients.

Digestion 2019 14;99(1):6-13. Epub 2018 Dec 14.

Department of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation of Cancer Research, Tokyo, Japan.

Background: The incidence trend of esophagogastric junction (EGJ) adenocarcinoma in Japan has not been sufficiently investigated. Little is known about the microsatellite instability (MSI) status of this tumor.

Summary: Previously published studies analyzing the trend of EGJ adenocarcinoma in Japan were reviewed. Read More

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http://dx.doi.org/10.1159/000494406DOI Listing
December 2018
2 Reads

Questionnaire-Based Survey on Management of Ulcerative Colitis-Associated Cancer in East Asian Countries.

Digestion 2019 14;99(1):86-94. Epub 2018 Dec 14.

Sino United Health Clinic, Gopher Medical Center, Rui Jing Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background/aims: To elucidate the current management of ulcerative colitis (UC)-associated cancer, a questionnaire-based survey was conducted to gather current opinions on colitis-associated cancer in different East Asian countries.

Methods: The questionnaire, based on physicians, contains 9 questions focused on UC management and cancer surveillance. In addition, the questionnaire based on neoplastic cases, which contains 17 questions, was collected and analyzed. Read More

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http://dx.doi.org/10.1159/000494419DOI Listing
December 2018
2 Reads

Endoscopic Submucosal Dissection in Patients with Ulcerative Colitis.

Digestion 2019 14;99(1):27-32. Epub 2018 Dec 14.

Department of Gastroenterology, National Hospital Organization Tokyo Medical Center, Tokyo,

Patients with ulcerative colitis have an increased risk of developing colorectal cancer. This risk has been estimated to reach about 7% at 20 years of disease, 7-14% at 25 years, and as high as 30% after 35 years. The guidelines for the management of inflammatory bowel disease recommend endoscopic resection of circumscribed dysplasia and ongoing colonoscopic surveillance as a reasonable strategy in patients with ulcerative colitis. Read More

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http://dx.doi.org/10.1159/000494409DOI Listing
December 2018
2 Reads

Clinical Outcomes of Patients with Small Rectal Neuroendocrine Tumors Treated Using Endoscopic Submucosal Resection with a Ligation Device.

Digestion 2019 14;99(1):72-78. Epub 2018 Dec 14.

Department of Gastroenterology, NTT Medical Center Tokyo, Tokyo,

Background/aims: The therapeutic strategies for small rectal neuroendocrine tumors (NETs) have not been standardized. We examined the efficacy and safety of endoscopic submucosal resection with a ligation device (ESMR-L) and the long-term outcomes after endoscopic treatment.

Methods: A total of 181 patients with rectal NETs <10 mm who were treated between May 2002 and May 2017 were retrospectively enrolled. Read More

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http://dx.doi.org/10.1159/000494416DOI Listing
December 2018
1 Read

Metabolic Alterations in Celiac Disease Occurring after Following a Gluten-Free Diet.

Digestion 2018 Dec 14:1-7. Epub 2018 Dec 14.

Gastroenterology Unit, Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila,

Background And Aim: Many investigations have demonstrated that changes in body weight are frequent in patients with coeliac disease (CD) after a gluten-free diet (GFD); conversely data on the metabolic syndrome (MS) and hepatic steatosis (HS) are still rare. The aim is to evaluate the prevalence of MS and HS in patients with CD, before and after a GFD.

Methods: One hundred eighty-five coeliac adult patients were enrolled in the study. Read More

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http://dx.doi.org/10.1159/000495749DOI Listing
December 2018
2 Reads

Integrated Analysis of the Endoscopic, Pathological and Molecular Characteristics of Colorectal Tumorigenesis.

Digestion 2019 14;99(1):33-38. Epub 2018 Dec 14.

Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, Morioka, Japan.

Background: Colorectal cancers (CRCs) develop through the accumulation of genetic and epigenetic alterations of oncogenes and tumor suppressor genes. In addition to the well-characterized adenoma-carcinoma sequence, the serrated neoplasia pathway is now recognized as an alternative pathway for CRC development.

Summary: Through analysis of the colonoscopic, pathological, and molecular features of colorectal tumors, we identified a novel microsurface structure characteristic of serrated lesions. Read More

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https://www.karger.com/Article/FullText/494410
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http://dx.doi.org/10.1159/000494410DOI Listing
December 2018
9 Reads

Shorter Relapse-Free Period after Leukocyte Removal Therapy in Younger than Older Patients with Ulcerative Colitis.

Digestion 2018 Dec 12:1-7. Epub 2018 Dec 12.

Department of Internal Medicine, Saga Medical School, Saga, Japan.

Background: Leukocyte removal therapy (LRT) is an effective treatment for active ulcerative colitis (UC). The present study was performed to evaluate the relapse-free period after LRT and identify risk factors for relapse.

Methods: In total, 94 patients who underwent first-time LRT for remission of moderate to severe UC from April 2004 to March 2016 were enrolled in the present study. Read More

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http://dx.doi.org/10.1159/000495503DOI Listing
December 2018
8 Reads

Gastric Focal Neutrophil Infiltration and Wide Duodenal Gastric Foveolar Metaplasia Are Histologic Discriminative Markers for Crohn's Disease and Behçet's Disease.

Digestion 2018 Dec 12:1-10. Epub 2018 Dec 12.

Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.

Background/aims: Behçet's disease (BD) with intestinal lesions and Crohn's disease (CD) share clinical features. However, no report has compared the 2 diseases with regard to lesions of the upper gastrointestinal tract (UGT). We aimed to evaluate endoscopic and histologic findings of UGT in CD and BD. Read More

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http://dx.doi.org/10.1159/000494922DOI Listing
December 2018
1 Read

Nonalcoholic-Fatty-Liver-Disease and Nonalcoholic Steatohepatitis: Successful Development of Pharmacological Treatment Will Depend on Translational Research.

Digestion 2018 Dec 7:1-7. Epub 2018 Dec 7.

Background: Nonalcoholic-fatty-liver-disease/nonalcoholic steatohepatitis (NAFLD/NASH) is expected to become the leading liver disease worldwide. Typical liver-related complications are fibrosis, cirrhosis, and the development of hepatocellular cancer (HCC) with the need for liver transplantation. Up to now there is no approved pharmacotherapy. Read More

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http://dx.doi.org/10.1159/000493259DOI Listing
December 2018
4 Reads

Efficacy of Clutch Cutter for Standardizing Endoscopic Submucosal Dissection for Early Gastric Cancer: A Propensity Score-Matched Analysis.

Digestion 2018 Dec 6:1-9. Epub 2018 Dec 6.

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Background/aims: The purpose of this study was to evaluate the safety and efficacy of gastric endoscopic submucosal dissection (ESD) using the Clutch Cutter (CC), a scissor-type knife, compared with those of procedures using conventional devices.

Methods: This single-center retrospective study evaluated 237 patients with early gastric cancer: 83 who underwent ESD using the CC group and 154 who underwent ESD using the insulated-tip knife 2 (IT2 group). Clinicopathological features and technical outcomes were compared between the 2 groups using a propensity score-matched analysis. Read More

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https://www.karger.com/Article/FullText/495287
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http://dx.doi.org/10.1159/000495287DOI Listing
December 2018
14 Reads

Effect of Continued Administration of Low-dose Aspirin for Intraoperative Bleeding Control in Gastric Endoscopic Submucosal Dissection.

Digestion 2018 Dec 4:1-8. Epub 2018 Dec 4.

Background: The use of antithrombotic agents for the prevention of cerebro-cardioembolic events has increased, and recent guidelines have recommended the continued administration of low-dose aspirin (LDA) during endoscopic procedures with a high risk of bleeding. However, the influence of LDA on intraoperative bleeding control status during Endoscopic submucosal dissection (ESD) remains unclear.

Methods: We examined 293 consecutive patients who underwent ESD for gastric cancers between January 2014 and February 2018. Read More

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https://www.karger.com/Article/FullText/494250
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http://dx.doi.org/10.1159/000494250DOI Listing
December 2018
4 Reads

Gankyrin Contributes to Tumorigenesis and Chemoresistance in Sporadic Colorectal Cancer.

Digestion 2018 Dec 4:1-9. Epub 2018 Dec 4.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.

Background: Although Gankyrin is overexpressed in many malignancies, the role of Gankyrin for tumorigenesis and chemoresistance remains to be elucidated in sporadic colorectal cancer (CRC).

Aims: We investigate whether Gankyrin affects Adenomatous polyposis coli (Apc) inactivation-induced tumorigenesis and therapeutic response to anti-angiogenic agents.

Methods: Epithelial cell-specific APC and/or Gankyrin-deficient mice were used. Read More

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http://dx.doi.org/10.1159/000494969DOI Listing
December 2018
6 Reads

Chemopreventive Effect of Rebamipide against Gastric Cancer in Patients who undergo Endoscopic Resection for Early Gastric Neoplasms: A Nationwide Claims Study.

Digestion 2018 Nov 28:1-8. Epub 2018 Nov 28.

Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of

Background/aims: Previous studies have shown that rebamipide is potentially protective against gastric cancer; however, no epidemiologic studies of its chemopreventive effects in patients who have a high risk of gastric cancer have been performed. The aim of this study was to investigate whether rebamipide administration reduces the risk of gastric cancer.

Methods: We conducted a population-based cohort study using data retrospectively collected from the Health Insurance Review and Assessment Service database in Korea. Read More

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http://dx.doi.org/10.1159/000495288DOI Listing
November 2018
2 Reads

Utility of Endoscopic Submucosal Dissection in the Remnant Stomach and Clinical Outcomes for Different Reconstruction Methods.

Digestion 2018 Nov 28:1-8. Epub 2018 Nov 28.

Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan.

Background: The number of patients with remnant gastric tumor during postoperative follow-up is increasing. We evaluated clinical outcomes to determine the feasibility of endoscopic submucosal dissection (ESD) for early gastric neoplasm in the remnant stomach.

Methods: We compared 138 lesions of ESD in the remnant stomach after proximal gastrectomy, distal gastrectomy (DG) or pylorus-preserving DG with 3,237 lesions of ESD in the intact stomach. Read More

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http://dx.doi.org/10.1159/000495346DOI Listing
November 2018
2 Reads

The Present Status and Future of Barrett's Esophageal Adenocarcinoma in Japan.

Digestion 2019 27;99(2):185-190. Epub 2018 Nov 27.

Division of Gastroenterological Surgery, Tokai University, Oiso, Japan.

Background: The incidence of esophageal adenocarcinoma in Europe and the United States rapidly increased from the latter half of the 1970s and exceeded that of esophageal squamous cell carcinoma in the latter half of the 1990s, currently accounting for approximately 60% of all esophageal carcinomas. Recently, its incidence has also increased in Japan, raising concerns that it will follow a course similar to that in Europe and the United States.

Summary: The incidence of esophageal adenocarcinoma in Japan was about 2% until the 1990s, but in recent years, it has risen to 6. Read More

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http://dx.doi.org/10.1159/000490508DOI Listing
November 2018
10 Reads

Trends in Post-Therapeutic Endoscopic Retrograde Cholangiopancreatography Gastrointestinal Hemorrhage, Perforation and Mortality from 2000 to 2012: A Nationwide Study.

Digestion 2018 Nov 22:1-9. Epub 2018 Nov 22.

Division of Gastroenterology and Hepatology, Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Background/aims: Recent trends in complications following inpatient therapeutic Endoscopic Retrograde Cholangiopancreatography (ERCP) remain poorly defined. We studied trends of gastrointestinal (GI) hemorrhage, perforation, and mortality following inpatient therapeutic ERCPs from 2000 to 2012 with the hypothesis that ERCPs would have down trending complication rates.

Methods: First, we isolated therapeutic ERCPs in patients 18 years or older using the International Classification of Diseases, Ninth Edition in the 2000 to 2012 National Inpatient Sample databases. Read More

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http://dx.doi.org/10.1159/000494248DOI Listing
November 2018
6 Reads

Evaluation of Intestinal Patency with the Patency Capsule: The Twenty-Four Hour Assessment Method.

Digestion 2018 Nov 21:1-10. Epub 2018 Nov 21.

Introduction: Confirmation of intestinal patency using the patency capsule (PC) in 30-33 h may result in a complex testing schedule. The aim of this study was to perform and evaluate a 24-h PC procedure for potential use as a simple and easy-to-apply intestinal patency assessment method.

Subject And Methods: The study included 342 patients who were assessed 24 h after ingesting a PC for assessment of intestinal patency. Read More

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http://dx.doi.org/10.1159/000494717DOI Listing
November 2018
8 Reads

Contents Vol. 98, 2018.

Authors:

Digestion 2018 16;98(4):I-IV. Epub 2018 Nov 16.

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http://dx.doi.org/10.1159/000495018DOI Listing
November 2018
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Risk Factors for Delayed Hemorrhage after Colonic Endoscopic Mucosal Resection in Patients Not on Antithrombotic Therapy: Retrospective Analysis of 3,844 Polyps of 1,660 Patients.

Digestion 2018 Nov 16:1-7. Epub 2018 Nov 16.

Department of Internal Medicine, Faculty of Medicine, Saga Medical School, Saga,

Background/aims: Colonic endoscopic mucosal resection (EMR) is safe for patients without antithrombotic therapy; however, EMR is associated with several risks. This study was performed to evaluate the risk of delayed hemorrhage in patients undergoing EMR without antithrombotic therapy.

Methods: In the present retrospective single-center study, 1,792 patients without antithrombotic therapy underwent colonic EMR from March 2012 to December 2016 at the Saga Medical Centre Koseikan. Read More

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https://www.karger.com/Article/FullText/494455
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http://dx.doi.org/10.1159/000494455DOI Listing
November 2018
6 Reads

High Prevalence of Pathological Hydrogen Breath Tests in Patients with Functional Dyspepsia.

Digestion 2018 Nov 14:1-6. Epub 2018 Nov 14.

Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Goettingen, Goettingen, Germany.

Background/aims: The aim of the study is to investigate the frequency of pathological hydrogen breath tests (HBT) in patients with clinical features of functional dyspepsia (FD) meeting the Rome criteria and normal testing of upper endoscopy and abdominal sonography.

Methods: We retrospectively included patients who underwent HBT (lactose, fructose, or glucose) between 2006 and 2012 and who had symptoms of FD. Patients were divided into 2 groups according to medical history and diagnostic results: (I) patients with suspected FD according to the Rome III criteria and (II) patients with an alternative diagnosis such as gastroesophageal reflux disease (GERD) or Crohn's disease (CD). Read More

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http://dx.doi.org/10.1159/000494718DOI Listing
November 2018
12 Reads

Efficacy of Magnifying Narrow Band Imaging for Delineating Horizontal Margins of Early Gastric Cancer.

Digestion 2018 Nov 13:1-7. Epub 2018 Nov 13.

Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Background/aims: The aim of this study was to evaluate the diagnostic accuracy of magnifying narrow-band imaging (M-NBI) with histopathological confirmation in identifying the demarcation line (DL) of early gastric cancer (EGC).

Methods: EGCs resected by endoscopic submucosal dissection after identifying the DL using M-NBI following histopathological confirmation were included. After determining the DL for the entire EGC lesion using M-NBI, at least 4 biopsies were taken from non-cancerous tissues outside the EGC lesion for histopathological confirmation. Read More

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https://www.karger.com/Article/FullText/494053
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http://dx.doi.org/10.1159/000494053DOI Listing
November 2018
10 Reads

Contrast-Enhanced Sonography in Patients with Hyposplenia: A Retrospective Analysis in Forty-Three Patients.

Digestion 2018 Nov 13:1-6. Epub 2018 Nov 13.

Interdisziplinäre Ultraschallzentrum, Universitätsklinikum Gießen und Marburg, Philipps Universität Marburg, Marburg, Germany.

Purpose: In contrast to splenomegaly, the clinical value of a small spleen (hyposplenia) is unclear. Contrast-enhanced ultrasound (CEUS) has not been investigated systematically in hyposplenia.

Methods: Between February 2005 and January 2017, 43 patients with hyposplenia (< 7 × 3 cm) were examined by B-mode ultrasound (US) and CEUS. Read More

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http://dx.doi.org/10.1159/000494755DOI Listing
November 2018
3 Reads

An Open-Labeled Study on Fecal Microbiota Transfer in Irritable Bowel Syndrome Patients Reveals Improvement in Abdominal Pain Associated with the Relative Abundance of Akkermansia Muciniphila.

Digestion 2018 Nov 13:1-12. Epub 2018 Nov 13.

Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Munich,

Background/aims: The gut microbiota is altered in irritable bowel syndrome (IBS), and microbiota manipulations by diet or antibiotics can reduce its symptoms. As fecal microbiota transfer (FMT) in IBS is still controversial, we investigated the clinical and side effects of FMT in a cohort of IBS patients with recurrent, treatment refractory symptoms, and studied gut microbiota signatures.

Methods: Using an observational, prospective study design, we applied FMTs from one unrelated, healthy donor to 13 IBS patients. Read More

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https://www.karger.com/Article/FullText/494252
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http://dx.doi.org/10.1159/000494252DOI Listing
November 2018
11 Reads

The Effects of Direct Oral Anticoagulants, Warfarin, Aspirin and Thienopyridine on the Performance of Immunochemical, Faecal, Occult Blood Tests.

Digestion 2018 Nov 8:1-10. Epub 2018 Nov 8.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Aim: To clarify whether antithrombotic drugs affect diagnosis using the immunochemical faecal occult blood test -(iFOBT) of colorectal neoplasia.

Methods: Using the Japan Endoscopy Database from 8 centres between 2015 and 2017, we analyzed data about patients who were iFOBT positive and had received direct oral anticoagulants (DOAC), warfarin, aspirin or thienopyridine. One-to-one matching-analogue propensity score weighted analyses were performed to compare the positive predictive value (PPV) of all neoplasms, invasive and non-invasive colorectal cancers and adenomas between drug users and non-users. Read More

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http://dx.doi.org/10.1159/000494251DOI Listing
November 2018
18 Reads