150,949 results match your criteria Diffuse Sclerosis


Networks of problems: social, psychological, and genetic influences on health.

Curr Opin Psychol 2018 Nov 30;27:88-92. Epub 2018 Nov 30.

Department of Sociology, Stanford University, United States.

An emerging idea in psychopathology conceives of disorders as networks of mutually-reinforcing symptoms that constitute the disorder rather than simply reflect it. This is similar to how social scientists already view socioeconomic status, and has affinities to how physical health problems compound in later life. Social, psychological, and physical conditions might therefore be thought of as networks of problems with 'causal bridges' that span different levels and bring low SES, mental health challenges, and physical health problems into pervasive relationships with one another. Read More

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November 2018
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The expression levels of miRNA-15a and miRNA-16-1 in circulating tumor cells of patients with diffuse large B-cell lymphoma.

Mol Biol Rep 2018 Dec 14. Epub 2018 Dec 14.

Department of Cancer Genetics, Istanbul Faculty of Medicine, Oncology Institute, Istanbul University, Istanbul, Turkey.

MicroRNAs (miRNAs) have major roles in nearly all cellular process including gene expression, and may behave as oncogene or tumor suppressor gene by binding to complementary sequences in the target mRNA. The circulating microRNA-15a (miRNA-15a) and microRNA-16-1 (miRNA-16-1) of 15 healthy adults and of 40 untreated patients diagnosed with diffuse large B-cell lymphoma (DLBC) were recruited to investigate the expression levels. The expression levels of miRNA-15a, and miRNA-16-1 genes of the untreated DLBCL patients, and healthy individuals with matched age, sex and ethnicity were examined. Read More

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December 2018
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Radiographic stool quantification: an equivalence study of 484 symptomatic and asymptomatic subjects.

Abdom Radiol (NY) 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiology, Michigan Medicine, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA.

Purpose: To determine if symptomatic patients referred for radiographic stool quantification have equivalent stool burden to asymptomatic patients.

Method: This was an IRB-approved HIPAA-compliant retrospective equivalence cohort study. An a priori equivalence power calculation was performed. Read More

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December 2018

Direct-Acting Antivirals in Hepatitis C Virus-Associated Diffuse Large B-cell Lymphomas.

Oncologist 2018 Dec 14. Epub 2018 Dec 14.

Department of Molecular Medicine, University of Pavia, Pavia, Italy.

Background: International guidelines suggest hepatitis C virus (HCV) eradication by direct-acting antivirals (DAAs) after first-line immunochemotherapy (I-CT) in patients with HCV-positive diffuse large B-cell lymphoma (DLBCL), although limited experiences substantiate this recommendation. Moreover, only a few data concerning concurrent administration of DAAs with I-CT have been reported.

Subjects, Materials, And Methods: We analyzed hematological and virological outcome and survival of 47 consecutive patients with HCV-positive DLBCL treated at 23 Italian and French centers with DAAs either concurrently (concurrent cohort []: = 9) or subsequently (sequential cohort []: = 38) to first-line I-CT (mainly rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone [R-CHOP]-like). Read More

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December 2018

[Sweet's syndrome induced by pegfilgrastim during a myelodysplastic syndrome AREB2: A case report].

Rev Med Interne 2018 Dec 11. Epub 2018 Dec 11.

Service d'hématologie-oncologie, CHU Brugmann, 4, place Arthur Van Gehuchten, 1020 Bruxelles, Belgique.

Introduction: Sweet's syndrome is an acute neutrophilic dermatosis characterized by abrupt onset of skin lesions accompanied by fever, arthralgia, leukocytosis and diffuse neutrophilic infiltration of the dermis, as well as an excellent response to corticosteroid therapy.

Case Report: A 46-year-old patient with myelodysplastic syndrome was admitted for chemotherapy. On the eighth day of chemotherapy, he received a single dose of pegfilgrastim. Read More

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December 2018
2 Reads

Gangrenous appendicitis: No longer complicated.

J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.

Nationwide Children's Hospital, Department of Pediatric Surgery, 700 Children's Drive, Columbus, OH, 43205; The Ohio State University College of Medicine, 370 W 9th Ave, Columbus, OH, 43210. Electronic address:

Background: Appendicitis presents on a spectrum ranging from inflammation to gangrene to perforation. Studies suggest that gangrenous appendicitis has lower postoperative infection rates relative to perforated cases. We hypothesized that gangrenous appendicitis could be successfully treated as simple appendicitis, reducing length of stay (LOS) and antibiotic usage without increasing postoperative infections. Read More

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November 2018

Association between Polymorphisms in Inflammatory Response-Related Genes and the Susceptibility, Progression and Prognosis of the Diffuse Histological Subtype of Gastric Cancer.

Genes (Basel) 2018 Dec 13;9(12). Epub 2018 Dec 13.

Centro de Investigacao Translacional em Oncologia (LIM24), Departamento de Radiologia e Oncologia, Instituto do Cancer do Estado de Sao Paulo (ICESP), Faculdade de Medicina da Universidade de Sao Paulo (FMUSP), Sao Paulo 01246-000, Brazil.

The chronic inflammatory microenvironment and immune cell dysfunction have been described as critical components for gastric tumor initiation and progression. The diffuse subtype is related to poor clinical outcomes, pronounced inflammation, and the worst prognosis. We investigated the association of polymorphisms in inflammatory response-related genes (, , , , , , , , , , and ) with gastric cancer susceptibility, progression and prognosis in a Brazilian sample, focusing on the diffuse subtype. Read More

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December 2018

A 29-Year-Old Japanese Man Returning From Indonesia With Diffuse Maculopapular Rash.

Clin Infect Dis 2019 Jan;68(1):165-167

Center for Global Health, Mito Kyodo General Hospital, University of Tsukuba.

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January 2019
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Microfluidics-based self-assembly of peptide-loaded microgels: Effect of three dimensional (3D) printed micromixer design.

J Colloid Interface Sci 2018 Dec 4;538:559-568. Epub 2018 Dec 4.

Department of Pharmacy, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark; Department of Pharmacy, University of Uppsala, SE-75123 Uppsala, Sweden.

In an effort to contribute to research in scalable production systems for polymeric delivery systems loaded with antimicrobial peptides (AMPs), we here investigate effects of hydrodynamic flow conditions on microfluidic particle generation. For this purpose, rapid prototyping using 3D printing was applied to prepare micromixers with three different geometric designs, which were used to prepare Ca-cross-linked alginate microgels loaded with the AMP polymyxin B in a continuous process. Based on fluid dynamic simulations, the hydrodynamic flow patterns in the micromixers were designed to be either (i) turbulent with chaotic disruption, (ii) laminar with convective mixing, or (iii) convective with microvortex formation. Read More

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December 2018

Microfluidic assembly of hydrogel-based immunogenic tumor spheroids for evaluation of anticancer therapies and biomarker release.

J Control Release 2018 Dec 11. Epub 2018 Dec 11.

Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA. Electronic address:

Diffuse large B cell lymphoma (DLBCL), the most common subtype of Non-Hodgkin lymphoma, exhibits pathologic heterogeneity and a dynamic immunogenic tumor microenvironment (TME). However, the lack of preclinical in vitro models of DLBCL TME hinders optimal therapeutic screening. This study describes the development of an integrated droplet microfluidics-based platform for high-throughput generation of immunogenic DLBCL spheroids. Read More

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December 2018
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Integrated chemical exposure assessment of coastal green turtle foraging grounds on the Great Barrier Reef.

Sci Total Environ 2018 Nov 22;657:401-409. Epub 2018 Nov 22.

Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall St, Woolloongabba, Qld 4102, Australia.

The Great Barrier Reef receives run-off from 424,000 km catchment area across coastal Queensland, incorporating diffuse agricultural run-off, and run-off point sources of land-based chemical pollutants from urban and industrial development. Marine biota, such as green turtles (Chelonia mydas), are exposed to these diverse chemical mixtures in their natural environments, and the long term effects on turtle and ecosystem health remain unknown. This study was part of a larger multi-disciplinary project characterising anthropogenic chemical exposures from the marine environment and turtle health. Read More

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November 2018

Atypical Prenatal Ultrasound Presentation and Neuropathological Findings in a Neonate With Alpha Thalassemia Major: A Case Report.

Pediatr Dev Pathol 2018 Dec 14:1093526618817655. Epub 2018 Dec 14.

1 Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Canada.

Alpha thalassemia major is a hemoglobinopathy caused by the inactivation or deletion of all 4 α-globin alleles. We describe a case of α-thalassemia major with atypical ultrasound and neuropathological findings. The mother had her first prenatal visit at 27 4/7 gestational weeks. Read More

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December 2018

Real-time Visualization of Breast Carcinoma in Pathology Specimens From Patients Receiving Fluorescent Tumor-Marking Agent Tozuleristide.

Arch Pathol Lab Med 2018 Dec 14. Epub 2018 Dec 14.

From the Departments of Pathology (Dr Dintzis) and Surgery (Ms Hales and Drs Calhoun, Javid, and Byrd), University of Washington Medical Center, Seattle; Breast Surgery Clinic (Dr Harrington), Department of Pathology (Dr Tan), and Clinical Trials (Mses Fortney and Porenta), Overlake Hospital Medical Center, Bellevue, Washington; Development (Dr Miller), Clinical Operations (Mses Ishak and Gombotz), Research (Ms Hansen and Dr Parrish-Novak), and Device Development (Dr Kittle and Mr Perry), Blaze Bioscience, Inc., Seattle, Washington; and the Department of Surgery, University of Washington, Seattle (Dr Anderson).

Context.—: Resection of breast carcinoma with adequate margins reduces the risk of local recurrence and reoperation. Tozuleristide (BLZ-100) is an investigational peptide-fluorophore agent that may aid in intraoperative tumor detection and margin assessment. Read More

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December 2018

Machine learning approach for rapid and accurate estimation of optical properties using spatial frequency domain imaging.

J Biomed Opt 2018 Dec;24(7):1-6

University of Strasbourg, ICube Laboratory, Strasbourg, France.

Fast estimation of optical properties from reflectance measurements at two spatial frequencies could pave way for real-time, wide-field and quantitative mapping of vital signs of tissues. We present a machine learning-based approach for estimating optical properties in the spatial frequency domain, where a random forest regression algorithm is trained over data obtained from Monte-Carlo photon transport simulations. The algorithm learns the nonlinear mapping between diffuse reflectance at two spatial frequencies, and the absorption and reduced scattering coefficient of the tissue under consideration. Read More

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December 2018

Silk fibroin hydrogels for potential applications in photodynamic therapy.

Biopolymers 2018 Dec 13:e23245. Epub 2018 Dec 13.

Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, Brazil.

In this study, we prepared translucid hydrogels with different concentrations of silk fibroin, extracted from raw silk fibers, and used them as a matrix to incorporate the photosensitizer 5-(4-aminophenyl)-10,15,20-tris-(4-sulphonatophenyl) porphyrin trisodium for application in photodynamic therapy (PDT). The hydrogels obtained were characterized by rheology, spectrophotometry, and scattering techniques to elucidate the factors involved in the formation of the hydrogel, and to characterize the behavior of silk fibroin (SF) after incorporating of the porphyrin to the matrix. The rheology results demonstrated that the SF hydrogels had a shear thinning behavior. Read More

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December 2018
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Draf IIB with superior septectomy: finding the "middle ground".

Int Forum Allergy Rhinol 2018 Dec 12. Epub 2018 Dec 12.

Department of Otolaryngology-Head and Neck Surgery, University of Kansas Medical Center, Kansas City, KS.

Background: Previous studies have demonstrated a high failure rate of endoscopic sinus surgery (ESS) with Draf IIa in patients with diffuse polyposis, asthma, and aspirin-exacerbated respiratory disease. A high percentage of these patients progress to endoscopic modified Lothrop procedure (EMLP). We describe a modification of the Draf IIb with a superior septectomy (IIb+SS), which may provide similar therapeutic benefit as demonstrated by the distribution of sinus irrigations in the sinus cavity with ESS with IIb+SS vs ESS with EMLP IIb+SS vs ESS with EMLP. Read More

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December 2018

Atypical actinobacillosis affecting hind limbs and lungs in a single beef cattle herd.

J Vet Intern Med 2018 Dec 12. Epub 2018 Dec 12.

Clinic for Ruminants, Nantes, France.

Actinobacillosis usually is a sporadic infection that affects the tongue in cattle ("wooden tongue") with possible spread to the digestive tract. Two 4-year-old Rouge-des-Prés cows from a single French beef herd were referred for chronic (2-6 months) swelling and cutaneous nodules in the distal hind limbs. In addition to cutaneous signs, physical examination disclosed cachexia, lameness, lymphadenitis of the hind limbs, and pneumonia in both cows. Read More

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December 2018
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Correlation between morphology and anisotropic transport properties of diblock copolymers melts.

Soft Matter 2018 Dec 14. Epub 2018 Dec 14.

Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA.

Molecular simulations of coarse-grained diblock copolymers (DBP) were conducted to study the effect of segregation strength and morphology on transport properties. It was found that in the strong segregation limit (i.e. Read More

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December 2018

A phase II study of a modified hyper-CVAD frontline therapy for patients with adverse risk diffuse large B-cell and peripheral T-cell non-Hodgkin lymphoma.

Leuk Lymphoma 2018 Dec 14:1-8. Epub 2018 Dec 14.

j Department of Haematology , Peter MacCallum Cancer Centre , Melbourne , Australia.

To improve complete remission (CR) rates by reducing toxicity and enhancing delivery, we created a modified hyper-CVAD/MA regimen (cyclophosphamide, vincristine, doxorubicin, dexamethasone/methotrexate, cytarabine) by reducing the cytarabine dose (3 g/m to 2 g/m) and number of cycles (eight to six). We conducted a phase II trial in the pre-rituximab era in the intermediate-high international prognostic index (IPI) (≥2) de novo diffuse large B-cell lymphoma (DLBCL) and peripheral T-cell lymphoma (PTCL) (ACTRN12605000105640). CR rates were compared with reported IPI-stratified rates. Read More

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December 2018
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Cognitive training benefit depends on brain injury location in adolescents with traumatic brain injury: a pilot study.

Eur J Phys Rehabil Med 2018 Dec 14. Epub 2018 Dec 14.

School of Psychology, Faculty of Health Sciences, Australian Catholic University, Melbourne, Australia.

Background: Executive dysfunctioning after pediatric traumatic brain injury (TBI) has been linked to poor outcomes in school performance, social functioning and employment. The credibility of training-induced cognitive enhancement in TBI is threatened by its limited proof of benefit in executive skills of daily living.

Aim: Our primary aim was to investigate if cognitive intervention for improving impairments in executive functions in the chronic stage of traumatic brain injury is effective during adolescence. Read More

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December 2018
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Early Hereditary Diffuse Gastric Cancer (eHDGC) is Characterized by Subtle Genomic Instability and Active DNA Damage Response.

Pathol Oncol Res 2018 Dec 13. Epub 2018 Dec 13.

Division of Biomedical Science and Biochemistry, Research School of Biology, ANU College of Medicine, Biology and Environment, Australian National University, P.O. Box: 2601, Canberra, Australia.

Diffuse gastric cancer (DGC) is one of the two primary types of stomach cancer. Carriers of germline mutations in the gene encoding E-cadherin are predisposed to DGC. The primary aim of the present study was to determine if genomic instability is an early event in DGC and how it may lead to disease progression. Read More

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December 2018
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1.806 Impact Factor

[CARs, CRS and neurotoxicity: severe complications after administration of immunotherapy : Essentials for intensivists].

Med Klin Intensivmed Notfmed 2018 Dec 13. Epub 2018 Dec 13.

Klinik I für Innere Medizin, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

Background: The development of chimeric antigen receptor (CAR) T‑cells has shown promising results in relapsed/refractory B‑cell acute lymphoblastic leukemia/lymphoma (B-ALL) and diffuse large cell B‑cell lymphoma. Complications, especially cytokine release syndrome (CRS) and CAR T‑cell related encephalopathy syndrome (CRES), can be life threatening. The management of both plays a key role in CAR T‑cell therapy. Read More

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December 2018

A nanocrystalline monoclinic CaCO precursor of metastable aragonite.

Sci Adv 2018 Dec 12;4(12):eaau6178. Epub 2018 Dec 12.

Institute of Geology, University of Innsbruck, Innrain 52, Innsbruck 6020, Austria.

Despite its thermodynamical metastability at near-surface conditions, aragonite is widespread in marine and terrestrial sediments. It abundantly forms in living organisms, and its abiotic formation is favored in waters of a Mg/Ca ratio > 1.5. Read More

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December 2018

A Case of Mistaken Identity: Glutaric Aciduria Type I Masquerading as Postmeningitic Hydrocephalus.

J Clin Imaging Sci 2018 15;8:50. Epub 2018 Nov 15.

Department of Radiology and Imaging, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

We report the characteristic neuroimaging features of a rare metabolic leukodystrophy in an 8-year-old boy, born of consanguineous parenthood. The child presented with macrocrania, regression of milestones, and dystonia. The patient was referred for magnetic resonance imaging with a clinical diagnosis of postmeningitic hydrocephalus. Read More

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November 2018

Report of a case of platelet-rich fibrin-mediated revascularization of immature 12 with histopathological evaluation.

J Conserv Dent 2018 Nov-Dec;21(6):691-695

Department of Conservative Dentistry and Endodontics, Dr. R. Ahmed Dental College and Hospital, Kolkata, West Bengal, India.

The procedure of regeneration has shown promising results in the treatment of nonvital teeth with immature apices. However, the tissue being regenerated can only be confirmed through histological examination. This report describes an immature nonvital 12 with apical pathology which was treated via revascularization using 3% NaOCl and 17% ethylenediaminetetraacetic acid as irrigants; Ca(OH)2 as intracanal medicament and platelet-rich fibrin (PRF) as scaffold. Read More

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December 2018

A 17-Year-Old Boy With High-Functioning Autism, Gastrointestinal Illness, and Seizures.

Pediatrics 2018 Dec 13. Epub 2018 Dec 13.

Massachusetts General Hospital, Boston, Massachusetts; and

A healthy 17-year-old boy with a high-functioning pervasive developmental disorder presented to the emergency department after having a 4-minute episode of seizure-like activity in the setting of presumed viral gastroenteritis. Within an hour of emergency department arrival, he developed a forehead-sparing facial droop, right-sided ptosis, and expressive aphasia, prompting stroke team assessment and urgent neuroimaging. Laboratory results later revealed a serum sodium of 119 mmol/L. Read More

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December 2018
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Adjusted Chemotherapy According to Frailty Status in Elderly Patients With Diffuse Large B-Cell Lymphoma: Experience From a Single Referral Center in Mexico City.

Clin Lymphoma Myeloma Leuk 2018 Nov 17. Epub 2018 Nov 17.

Hematology and Oncology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Background: Chemotherapy is associated with significant toxicity in elderly patients treated for hematological malignancies. Adequate tools to identify the best tailored treatment are essential.

Patients And Methods: Medical charts of patients treated with adjusted chemotherapy for diffuse large B-cell lymphoma according to frailty status between August 1, 2013 and June 30, 2016 were included. Read More

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November 2018

Distinct Expression and Clinical Significance of Zinc Finger AN-1-Type Containing 4 in Oral Squamous Cell Carcinomas.

J Clin Med 2018 Dec 10;7(12). Epub 2018 Dec 10.

Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, C/Carretera de Rubín, s/n, 33011 Oviedo, Asturias, Spain.

Zinc finger AN1-type containing 4 (ZFAND4) has emerged as a promising prognostic marker and predictor of metastasis for patients with oral squamous cell carcinoma (OSCC). However, further validation is fundamental before clinical implementation. Hence, this study evaluated the expression pattern of ZFAND4 protein expression by immunohistochemistry using an independent cohort of 125 patients with OSCC, and correlations with the clinicopathologic parameters and disease outcome. Read More

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December 2018

Oral oxymatrine for hepatitis B cirrhosis: A systematic review protocol.

Medicine (Baltimore) 2018 Dec;97(49):e13482

Acupuncture and massage department, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Background: Characterized by diffuse hepatic fibrosis and nodule formation, hepatitis B cirrhosis (HBC), an important result of chronic hepatitis B development, mainly contains compensated and decompensated stage. Compensated cirrhosis can further develop into decompensated stage and hepatocellular carcinoma with serious complications and high mortality. Antiviral therapy using interferon (IFN) or nucleos(t)ide analogs (NUCs) is essential for improving the prognosis of the disease but IFN has large side effects while NUCs often develop drug resistance. Read More

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December 2018
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General hyperpigmentation induced by Grave's disease: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13279

Department of Endocrinology, The Second Affiliated Hospital of Zhejiang University School of Medicine.

Rationale: Hyperpigmentation is a common skin disease. However, there are few reported cases of Grave's disease with diffuse hyperpigmentation. We hereby described a rare case with diffuse hyperpigmentation induced by Grave's disease. Read More

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December 2018

Secondary skin involvement in gastric diffuse large B-cell lymphoma treated with chidamide: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13093

Department of Hematology.

Rationale: Diffuse large B-cell lymphoma (DLBCL) is a neoplasm of large B lymphoid cells that exhibits diffuse growth patterns. Patients may present with nodal and/or extranodal disease. The most common extranodal site is the gastrointestinal tract, while skin is less common. Read More

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December 2018

Impact of the H3K27M mutation on survival in pediatric high-grade glioma: a systematic review and meta-analysis.

Authors:

J Neurosurg Pediatr 2018 Nov 1:1-9. Epub 2018 Nov 1.

OBJECTIVEPediatric high-grade gliomas (pHGGs), including diffuse intrinsic pontine glioma, present a prognostic challenge given their lethality and rarity. A substitution mutation of lysine for methionine at position 27 in histone H3 (H3K27M) has been shown to be highly specific to these tumors. Data are accumulating regarding the poor outcomes of patients with these tumors; however, the quantification of pooled outcomes has yet to be done, which could assist in prioritizing management. Read More

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November 2018

The factors associated with hemorrhagic presentation in children with untreated brain arteriovenous malformation: a meta-analysis.

Authors:

J Neurosurg Pediatr 2018 Nov 1:1-12. Epub 2018 Nov 1.

OBJECTIVERupture of arteriovenous malformations (AVMs) would result in high mortality and prevalence of disability in pediatric patients. Decisions regarding the treatment of AVMs need to weigh the risk of rupture over the course of their natural history against the possibility of creating a lesion during treatment. Multiple factors have been proposed to predict hemorrhagic presentation of pediatric patients with AVMs. Read More

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November 2018

Phase I trial of convection-enhanced delivery of IL13-Pseudomonas toxin in children with diffuse intrinsic pontine glioma.

Authors:

J Neurosurg Pediatr 2018 Dec 1:1-10. Epub 2018 Dec 1.

OBJECTIVEIn this clinical trial report, the authors analyze safety and infusion distribution of IL13-Pseudomonas exotoxin, an antitumor chimeric molecule, administered via intratumoral convection enhanced delivery (CED) in pediatric patients with diffuse intrinsic pontine glioma (DIPG).METHODSThis was a Phase I single-institution, open-label, dose-escalation, safety and tolerability study of IL13-PE38QQR infused via single-catheter CED into 5 pediatric DIPG patients. IL13-PE38QQR was administered to regions of tumor selected by radiographic findings. Read More

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December 2018

[Myeloid Sarcoma of the Testis].

Hinyokika Kiyo 2018 Nov;64(11):459-463

The Department of Urology, Yokohama City Minato Red Cross Hospital.

A 68-year-old man with swelling of his left testis was referred to our hospital. There was no history of hematologic disease. The diameter of the testicular mass was 40 mm. Read More

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November 2018

[A Case of Refractory Hemorrhagic Cystitis in which Bleeding Control was Finally Achieved by Cystectomy].

Hinyokika Kiyo 2018 Oct;64(10):415-418

Hakodate Goryokaku Hospital.

A 60-year-old man presented at our hospital with gross hematuria. He had been treated for nephrotic syndrome with cyclophosphamide and steroids since he was in his 20s. We detected diffuse hemorrhagic cystitis on cystoscopy and diagnosed him with cyclophosphamide-induced hemorrhagic cystitis. Read More

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October 2018

Surface Energy Driven Liquid-Drop-Like Pseudoelastic Behaviors and In Situ Atomistic Mechanisms of Small-Sized Face-Centered-Cubic Metals.

Nano Lett 2018 Dec 13. Epub 2018 Dec 13.

The elastic strain of conventional metals is usually below ~1%. As the metals size decrease to approximate a few nanometers, their elastic strains can approach ~8%, and usually exhibit pseudoelastic strain that can be as large as ~35%. Previous studies suggested that the pseudoelastic behaviors of nanocrystals were attributed to distinctive mechanisms, including the release of stored elastic energies and the temperature-enhanced surface diffusion etc. Read More

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December 2018

Accurate and Unbiased Quantitation of Amyloid-β Fluorescence Images Using ImageSURF.

Curr Alzheimer Res 2018 Dec 12. Epub 2018 Dec 12.

Wicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Hobart. Australia.

Background: Images of amyloid-β pathology characteristic of Alzheimer's disease are difficult to consistently and accurately segment, due to diffuse deposit boundaries and imaging variations.

Methods: We evaluated the performance of ImageSURF, our open-source ImageJ plugin, which considers a range of image derivatives to train image classifiers. We compared ImageSURF to standard image thresholding to assess its reproducibility, accuracy and generalizability when used on fluorescence images of amyloid pathology. Read More

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December 2018

Evaluation of PECAM-1 and p38 MAPK expressions in cerebellum tissue of rats treated with caffeic acid phenethyl ester: A biochemical and immunohistochemical study.

Folia Morphol (Warsz) 2018 Dec 13. Epub 2018 Dec 13.

Department of Histology and Embryology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.

This study aimed to investigate the antioxidative and anti-inflammatory effects of caffeic acid phenethyl ester (CAPE) on damage caused to cerebellum tissue by diffuse traumatic head trauma via biochemical, histopathologic, and immuno-histochemical methods. Male Sprague-Dawley (300-350g) rats were subjected to traumatic brain injury with a weight-drop device (300 g-1 m weight-height impact). Twenty-four adult rats were randomly divided into three equal groups of 8, including a control group, traumatic brain injury (TBI) group, and TBI+CAPE treatment group (10μmol/kg/i. Read More

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December 2018

Genetic analysis of a case of Helicobacter pylori-uninfected intramucosal gastric cancer in a family with hereditary diffuse gastric cancer.

Gastric Cancer 2018 Dec 12. Epub 2018 Dec 12.

Kansai Electric Power Hospital, Osaka, Japan.

Germline mutations in CDH1, encoding E-cadherin, are known to be the causative mechanism of hereditary diffuse gastric cancer (HDGC). We encountered two cases of gastric cancer in a Japanese family with HDGC. A 28-year-old man (Case 1) died of advanced gastric cancer. Read More

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December 2018

Whole genome duplication is an early event leading to aneuploidy in -wild type glioblastoma.

Oncotarget 2018 Nov 13;9(89):36017-36028. Epub 2018 Nov 13.

Département de Pathologie Cellulaire et Tissulaire, CHU Angers, Angers, France.

Glioblastoma, the most frequent and lethal form of glioma, displays chromosome instability and recurrent somatic copy number alterations (SCNA). Chromothripsis and whole genome duplication (WGD) have been recently identified in cancer. In the present study, we analyzed SCNA and determine the ploidy pattern in 123 -wild-type glioblastomas, using SNP array data. Read More

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November 2018

Drug-induced aneuploidy and polyploidy is a mechanism of disease relapse in MYC/BCL2-addicted diffuse large B-cell lymphoma.

Oncotarget 2018 Nov 13;9(89):35875-35890. Epub 2018 Nov 13.

Department of Medicine, University of Arizona Cancer Center, Tucson, AZ, USA.

Double-hit (DH) or double-expresser (DE) lymphomas are high-grade diffuse large B-cell lymphomas (DLBCL) that are mostly incurable with standard chemo-immunotherapy due to treatment resistance. The generation of drug-induced aneuploid/polyploid (DIAP) cells is a common effect of anti-DLBCL therapies (e.g. Read More

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November 2018

Leydig cell tumor in an Amur tiger (Panthera tigris altaica).

J Vet Med Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Veterinary Pathology, School of Veterinary Medicine, Nippon Veterinary and Life Science University.

A 14-year and 8-month-old intact male Amur tiger presented with an enlarged left testis, measuring 5.7 × 5.5 × 4. Read More

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December 2018
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Current perspectives on autoimmune pancreatitis and IgG4-related disease.

Proc Jpn Acad Ser B Phys Biol Sci 2018 ;94(10):412-427

Department of Gastroenterology and Hepatology, Kansai Medical University.

IgG4-related disease (IgG4-RD) is a fibroinflammatory disorder recognized as a novel clinical entity with either synchronous or metachronous multi-organ involvement. Patients with IgG4-RD show diffuse or focal organ enlargement and mass-forming or nodular/thickened lesions with abundant infiltration of IgG4-positive plasmacytes and fibrosis, and such patients respond well to steroid treatment. It should be differentiated from mimics by a combination of serum IgG4 level, imaging features, and histopathological findings. Read More

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January 2018

Porcine hemagglutinating encephalomyelitis virus activation of the integrin α5β1-FAK-Cofilin pathway causes cytoskeletal rearrangement to promote its invasion of N2a cells.

J Virol 2018 Dec 12. Epub 2018 Dec 12.

Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130062, China

Porcine hemagglutinating encephalomyelitis virus (PHEV) is a highly neurotropic virus that causes diffuse neuronal infection with neurological damage and high mortality. Virus-induced cytoskeletal dynamics are thought to be closely related to this type of nerve damage. Currently, the regulation pattern of the actin cytoskeleton and its molecular mechanism remain unclear when PHEV enters the host cells. Read More

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December 2018

The treatment results in patients with lmphoma disease in the orbit.

Cesk Slov Oftalmol 2018 ;73(5-6):211-217

Introduction: Lymphoma is a malignant disease that can affect several structures of the orbit and eye adnexa. In the area of orbit the non-Hodgkins lymphoma (NHL) is typical, which may be indolent or aggressive. Indolent subtypes include MALT (mucosa-associated lymphoid tissue), follicular lymphoma (FL), lymphoplasmocytic lymphoma (LPL). Read More

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January 2018

mutations cause variable phenotypes of developmental and epileptic encephalopathy.

Epilepsia Open 2018 Dec 1;3(4):495-502. Epub 2018 Nov 1.

Department of Pediatrics Showa University School of Medicine Shinagawa-ku, Tokyo Japan.

Objective: Vitamin B-dependent epilepsies are treatable disorders caused by variants in several genes, such as ,, and others. Recently, biallelic variants in formerly known as , were identified as a novel cause of vitamin B-dependent epilepsies. Our objective was to further delineate the phenotype of mutation. Read More

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December 2018

Establishment and characterization of a novel vincristine-resistant diffuse large B-cell lymphoma cell line containing the 8q24 homogeneously staining region.

FEBS Open Bio 2018 Dec 20;8(12):1977-1991. Epub 2018 Nov 20.

Division of Hematology Department of Internal Medicine Aichi Medical University Japan.

Chromosome band 8q24 is the most frequently amplified locus in various types of cancers. has been identified as the primary oncogene at the 8q24 locus, whereas a long noncoding gene, , which lies adjacent to , has recently emerged as another potential oncogenic regulator at this position. In this study, we established and characterized a novel cell line, AMU-ML2, from a patient with diffuse large B-cell lymphoma (DLBCL), displaying homogeneously staining regions at the 8q24 locus. Read More

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December 2018