1,212 results match your criteria Diffuse Idiopathic Skeletal Hyperostosis


Outcomes and complications of surgical treatment of anterior osteophytes causing dysphagia: Single center experience.

Clin Neurol Neurosurg 2021 Jul 10;207:106814. Epub 2021 Jul 10.

Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA. Electronic address:

Study Design: Retrospective case series.

Objective: To better understand the functional swallow outcomes, cervical balance, and surgical complications, we examined patients with anterior osteophytes and dysphagia who were treated operatively.

Summary Of Background Data: Anterior osteophytes from diffuse idiopathic skeletal hyperostosis (DISH) or degenerative etiology of the cervical spine can cause dysphagia from mechanical compression of the esophagus. Read More

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Ectopic mineralisation of the mandibular symphysis in knockout mice: A model of dystrophic calcification.

Bone Rep 2021 Dec 18;15:101100. Epub 2021 Jun 18.

Bone and Joint Institute, The University of Western Ontario, London, Ontario, Canada.

Equilibrative nucleoside transporter 1 (ENT1) transfers nucleosides, such as adenosine, across plasma membranes. We reported previously that mice lacking ENT1 ( ) exhibit progressive ectopic calcification of spinal tissues-a phenotype resembling diffuse idiopathic skeletal hyperostosis (DISH) in humans. Our objective was to investigate potential calcification of orofacial tissues in mice. Read More

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December 2021

Urinary Retention as the Presenting Clinical Manifestation of Unstable Thoracic Spinal Fracture with Diffuse Idiopathic Skeletal Hyperostosis.

Clin Med Insights Case Rep 2021 23;14:11795476211027988. Epub 2021 Jun 23.

Department of Emergency, Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kita-ku, Okayama, Japan.

Patients with diffuse idiopathic skeletal hyperostosis (DISH) are at high risk for unstable vertebral fracture, which can be frequently missed. An 80-year-old man with pre-existing muscle lower limb weakness due to frailty was referred from another hospital, presenting with progressive urinary retention and its related symptoms, which had been treated as a urinary tract infection at previous hospital. One week prior to our visit, he had fallen. Read More

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[Spinefractures - diagnosis and treatment].

Ugeskr Laeger 2021 07;183(27)

Acute onset back pain is a common reason for referral to primary health care or emergency departments. In this review, the different spine fracture types are highlighted, and a treatment algorithm is proposed. CT is the modality of choice when a spine fracture is suspected. Read More

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Accumulated Knowledge of Activin Receptor-Like Kinase 2 (ALK2)/Activin A Receptor, Type 1 (ACVR1) as a Target for Human Disorders.

Biomedicines 2021 Jun 26;9(7). Epub 2021 Jun 26.

Research Center for Genomic Medicine, Division of Biomedical Sciences, Saitama Medical University, Hidaka-shi, Saitama 350-1241, Japan.

Activin receptor-like kinase 2 (ALK2), also known as Activin A receptor type 1 (ACVR1), is a transmembrane kinase receptor for members of the transforming growth factor-β family. Wild-type ALK2/ACVR1 transduces osteogenic signaling in response to ligand binding. Fifteen years ago, a gain-of-function mutation in the gene was detected in patients with the genetic disorder fibro-dysplasia ossificans progressiva, which is characterized by heterotopic ossification in soft tissues. Read More

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The impact of diabetes mellitus on spinal fracture with diffuse idiopathic skeletal hyperostosis: A multicenter retrospective study.

J Orthop Sci 2021 Jun 20. Epub 2021 Jun 20.

Dept. of Orthopaedic Surgery, Keio University, Tokyo, Japan; Japanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo, Japan. Electronic address:

Background: Patients with diffuse idiopathic skeletal hyperostosis (DISH) are susceptible to spinal column injuries with neurological deterioration. Previous studies indicated that the prevalence of diabetes mellitus (DM) in patients with DISH was higher than that in patients without DISH. This study investigates the impact of DM on surgical outcomes for spinal fractures in patients with DISH. Read More

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Anterior cervical surgery to treat diffuse idiopathic skeletal hypertrophic combined with cervical disc herniation: A case report.

Medicine (Baltimore) 2021 Jun;100(22):e26097

Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China.

Rationale: Diffuse idiopathic skeletal hyperostosis (DISH) is a skeletal disease characterized by calcification of anterolateral ligaments of the spine and the rest of the body. DISH combined with disc herniation induces complex symptoms and is more difficult to treat. Here, we describe a complicated case of a patient diagnosed with DISH as well as cervical disc herniation that was successfully treated using anterior cervical surgery. Read More

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Unusual cause of dysphagia and dysphonia.

BMJ Case Rep 2021 Jun 2;14(6). Epub 2021 Jun 2.

Department of Otorhinolaryngology and Head and Neck Surgery, Medanta The Medicity, Gurgaon, Haryana, India.

Forestier's disease is an idiopathic noninflammatory condition associated with enthesopathy leading to hyperostosis of the vertebrae and peripheral skeletal system. The disease tends to affect elderly individuals and remains asymptomatic in most of the cases. Uncommonly, the patient may present with upper aerodigestive symptomatology, usually dysphagia. Read More

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Otolaryngologic manifestations of diffuse idiopathic skeletal hyperostosis (Forestier's disease): A systematic review of the literature.

Joint Bone Spine 2021 May 19;88(6):105218. Epub 2021 May 19.

Department of Otolaryngology - Head and Neck Surgery, Hôtel Dieu de France Hospital, Saint-Joseph University, 166830 Beirut, Lebanon. Electronic address:

Objectives: Forestier's disease or diffuse idiopathic skeletal hyperostosis (DISH) is a common, yet underreported, disease affecting the elderly population. From an otolaryngologic perspective, DISH may manifest with dysphagia, dysphonia, or even dyspnea. The purpose of this study was to identify all published cases of dysphagia and other associated upper airway symptoms resulting from DISH in the last decade and to establish subsequently a management algorithm. Read More

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Percutaneous, PMMA-augmented, pedicle screw instrumentation of thoracolumbar ankylotic spine fractures.

J Orthop Surg Res 2021 May 17;16(1):317. Epub 2021 May 17.

Medical faculty, Bar-Ilan University, Safed, Israel.

Introduction: Fractures in the ankylotic spine may have an insidious presentation but are prone to displace with devastating consequences. The long lever arm of ankylosed spine fragments may lead to pulmonary and great vessel injury and is difficult to adequately immobilize. Conservative treatment will produce in many cases poor outcomes with high morbidity and mortality. Read More

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Intercostal artery rupture associated with thoracic spinal hyperextension injury caused by a minor trauma: A case report.

Trauma Case Rep 2021 Jun 21;33:100487. Epub 2021 Apr 21.

Department of Orthopedic Surgery, Nara Medical University, 840 Shijotyo, Kashihara City, 654-8522, Nara, Japan.

Diffuse idiopathic skeletal hyperostosis is associated with hyperextension injury of the spine caused by a minor trauma and may often be diagnosed late, thus preventing effective treatment. To date, there have been no reported cases of segmental arterial injury associated with a hyperextension injury caused by a minor trauma in super-elderly patients with diffuse idiopathic skeletal hyperostosis. Herein, we present the findings and treatment provided for a 92-year-old woman with a right massive hemothorax and 12th thoracic vertebral fracture. Read More

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Chronic active non-lethal human-type tuberculosis in a high royal Bavarian officer of Napoleonic times-a mummy study.

PLoS One 2021 4;16(5):e0249955. Epub 2021 May 4.

Institute of Legal Medicine, Ludwig-Maximilians University (LMU), Munich, Germany.

In paleopathology, morphological and molecular evidence for infection by mycobacteria of the M. tuberculosis complex (MTC) is frequently associated with early death. In the present report, we describe a multidisciplinary study of a well-preserved mummy from Napoleonic times with a long-standing tuberculous infection by M. Read More

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Diffuse Idiopathic Skeletal Hyperostosis of Cervical Spine with Dysphagia-Molecular and Clinical Aspects.

Int J Mol Sci 2021 Apr 20;22(8). Epub 2021 Apr 20.

Adult Spine Orthopaedics Department, Poznan University of Medical Sciences, 61-545 Poznan, Poland.

Diffuse idiopathic skeletal hyperostosis (DISH) is a condition characterized by the calcification and ossification of the ligaments of the cervical spine; in some cases, it may result in dysphagia. The condition is more common in men over 50 years of age with metabolic disorders, and it is often asymptomatic and not a major issue for patients. The etiology of DISH is poorly understood, and known genetic factors indicate multiple signal pathways and multigene inheritance. Read More

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Association of Continuous Vertebral Bone Bridges and Bone Mineral Density with the Fracture Risk in Patients with Diffuse Idiopathic Skeletal Hyperostosis.

Asian Spine J 2021 May 3. Epub 2021 May 3.

Department of Orthopedic Surgery, Keio University, Tokyo, Japan.

Study Design: Cross-sectional study.

Purpose: To examine whether the number of continuous vertebral bone bridges and bone mineral density (BMD) influence the fracture risk in diffuse idiopathic skeletal hyperostosis (DISH) patients.

Overview Of Literature: Bone bridges connecting through the intervertebral body in DISH create long lever arms that can increase the risk of fractures from minor trauma. Read More

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Clinical Results of Vertebral Fracture Related to Diffuse Idiopathic Skeletal Hyperostosis (DISH) Which Underwent Conservative Treatment: Three Case Reports.

Int J Spine Surg 2021 Feb 18;15(1):195-202. Epub 2021 Feb 18.

Department of Orthopaedic Surgery, University of Miyazaki Faculty of Medicine, Miyazaki, Japan.

Background: A vertebral fracture in a patient with diffuse idiopathic skeletal hyperostosis (DISH) is unstable due to larger moment via the long lever arm of an ankylosed spine. Therefore, surgical treatment is commonly recommended to avoid complications of nonunion and paralysis. In this report, we present 3 cases of vertebral fractures related to DISH which were primarily forced to undertake conservative treatment because of medical comorbidities and advanced age. Read More

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February 2021

Fusion for subaxial bow hunter's syndrome results in remote osseous remodeling of the hyperostotic growth responsible for vertebral artery compression.

Surg Neurol Int 2021 17;12:104. Epub 2021 Mar 17.

Department of Neurosurgery, Naval Medical Center San Diego, San Diego, California, United States.

Background: The authors present a previously unreported case of a patient with diffuse idiopathic skeletal hyperostosis (DISH) who developed bow hunter's syndrome (BHS) or positional vertebrobasilar insufficiency. In addition, the authors demonstrate angiographic evidence of remote osseous remodeling after segmental fusion without direct decompression of the offending bony growth. BHS is a rare, yet well established, cause of posterior circulation ischemia and ischemic stroke. Read More

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Diffuse Idiopathic Skeletal Hyperostosis Causes Acute Airway Obstruction Following Upper Respiratory Tract Infection: A Case Report.

Spine Surg Relat Res 2021 10;5(2):114-116. Epub 2020 Jul 10.

Department of Orthopaedic Surgery, Faculty of Medicine, Saga University, Saga, Japan.

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Posterior spinal fixation using penetrating endplate screws in patients with diffuse idiopathic skeletal hyperostosis-related thoracolumbar fractures.

J Neurosurg Spine 2021 Apr 9:1-6. Epub 2021 Apr 9.

1Orthopedic Surgery, Sanmu Medical Center, Chiba, Japan; and.

Objective: Diffuse idiopathic skeletal hyperostosis (DISH)-related vertebral fractures essentially require operative treatment due to severe fracture site instability and high potential risk of posttraumatic neurological deficit. However, the optimal surgical procedure remains unclear. The purpose of this study was to assess the efficacy of posterior spinal fixation with penetrating endplate screws (PESs) for DISH-related thoracolumbar fractures. Read More

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Usefulness of dynamic stabilisation with mobile percutaneous pedicle screw for thoracic vertebral fractures in diffuse idiopathic skeletal hyperostosis.

BMJ Case Rep 2021 Apr 7;14(4). Epub 2021 Apr 7.

Department of Orthopaedic Surgery, Chiba University, Chiba, Japan.

We report a case of vertebral fracture with diffuse idiopathic skeletal hyperostosis (DISH) who underwent posterior dynamic stabilisation using mobile percutaneous pedicle screws (PPS) with 1 above-1 below and obtained good bone fusion. A 76-year-old man experienced severe low back pain after he fell backward 1 m off a stepladder during work. A 12th thoracic vertebral fracture with DISH was observed. Read More

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Dystrophic calcification and heterotopic ossification in fibrocartilaginous tissues of the spine in diffuse idiopathic skeletal hyperostosis (DISH).

Bone Res 2020 Apr 2;8(1):16. Epub 2020 Apr 2.

Bone and Joint Institute, The University of Western Ontario, London, ON, N6G 2V4, Canada.

Diffuse idiopathic skeletal hyperostosis (DISH) is a prevalent noninflammatory spondyloarthropathy characterized by ectopic mineral formation along the anterolateral aspect of the vertebral column, yet little is known about its underlying pathogenesis. Our objective was to evaluate the histopathological features and composition of ectopic mineral within spinal tissues affected by DISH in humans. Thoracic spine segments from six embalmed cadaveric donors (one female and five males; median age 82 years) meeting the radiographic diagnostic criteria for DISH were evaluated using radiological, histological, and physical analyses. Read More

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Idiopathic dorsal spinal cord herniation perforating the lamina: a case report and review of the literature.

Acta Neurochir (Wien) 2021 Aug 21;163(8):2313-2318. Epub 2021 Mar 21.

Department of Orthopaedic Surgery, School of Medicine, International University of Health and Welfare (IUHW), 852 Hatakeda, Narita City, Chiba, 286-0124, Japan.

Spinal cord herniation (SCH) is a rare condition associated with tethering of the spinal cord at the ventral dural defect. Idiopathic dorsal spinal cord herniation (IDSCH) is an extremely rare clinical entity. Here, we report the first case of IDSCH perforating the lamina in a patient with a history of ossification of the ligamentum flavum and diffuse idiopathic skeletal hyperostosis. Read More

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An Unrecognized Ligament and its Ossification in the Craniocervical Junction: Prevalence, Patient Characteristics, and Anatomic Evidence.

Clin Orthop Relat Res 2021 08;479(8):1816-1826

Department of Orthopaedic Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: In the craniocervical junction, the ligaments between the anterior foramen magnum and the anterior arch of the atlas are not well defined, and ossification of the ligaments in this region has rarely been reported. Characterizing the anatomy and ossification of these ligaments may help in the diagnosis and treatment of disorders in this region.

Questions/purposes: (1) What is the prevalence of an unrecognized ossification at the craniocervical junction in patients with cervical spine disorders, and what are the patient characteristics associated with this ossification? (2) Do patients with this ossification have a greater risk of ossification of other structures at the craniocervical junction or cervical spine? (3) Is there an unreported ligament at this ossified site?

Methods: We conducted a retrospective study of 578 hospitalized patients who underwent CT for cervical spine disorders between January 2016 and July 2020. Read More

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Cervical Myelopathy and Lumbar Spondylolisthesis in Elderly Patients with Diffuse Idiopathic Skeletal Hyperostosis (DISH) - A Case Series.

J Orthop Case Rep 2020 Nov;10(8):48-52

Department of Orthopaedics, Grant Government Medical College and sir JJ group of hospitals, Mumbai, Maharashtra, India.

Introduction: Diffuse idiopathic skeletal hyperostosis (DISH) is a non-inflammatory disease, which causes the ossification of spinal longitudinal ligaments and enthesis leads to stiffness in the affected segment of the spine and neurological deficit due to compression of spinal cord or nerve roots by osteophytes.

Case Presentation: We present three cases of DISH, presented with cervical myelopathy, lumbar spondylolisthesis, and dysphagia. All three patients had neurodeficit and radiological examination showed cord compression, canal stenosis, listhesis, and contiguous ossification in the spine with normal sacroiliac joints. Read More

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November 2020

Atypical Occipitocervical Dissociation Associated with Ossification of the Posterior Longitudinal Ligament and Diffuse Idiopathic Skeletal Hyperostosis in Low-Energy Trauma.

J Orthop Case Rep 2020 Nov;10(8):11-14

Department of Orthopedics, King Fahad General Hospital, Almadinah Almunawwarah, Saudi Arabia.

Introduction: Traumatic posterior occipitocervical dissociation (OCD) is a rare injury, and only a few cases have been reported in the literature. The diagnosis can be delayed or even missed because of its uncommon presentation. We present this rare case report and its management to highlight this unusual injury to increase the awareness of the existence of this pathology and prevent delayed diagnosis and treatment. Read More

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November 2020

Diffuse idiopathic skeletal hyperostosis in elderly Icelanders and its association with the metabolic syndrome: the AGES-Reykjavik Study.

Scand J Rheumatol 2021 Jul 7;50(4):314-318. Epub 2021 Mar 7.

Faculty of Medicine, University of Iceland, Reykjavík, Iceland.

: To describe the prevalence of diffuse idiopathic skeletal hyperostosis (DISH) in a large population-based study of elderly Icelanders, with particular reference to weight-related factors and the metabolic syndrome.: The study population comprised 5321 participants aged 68-96 years (2276 males, mean ± sd age 76 ± 5 , and 3045 females, age 77 ± 6) from the AGES-Reykjavik Study. DISH diagnosis was based on computed tomography (CT) scans, and interpreted strictly by the Resnick criteria and additional suggestions for CT interpretation by Oudkerk et al. Read More

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A Scoring System for Anterior Longitudinal Ligament Ossification of the Lumbar Spine in Diffuse Idiopathic Skeletal Hyperostosis: Relationship Between the Extent of Ligament Ossification and the Range of Motion.

Global Spine J 2021 Mar 3:2192568221996681. Epub 2021 Mar 3.

Department of Orthopedic Surgery, Ehime University School of Medicine, Shitsukawa, Tohon City, Ehime, Japan.

Study Design: Retrospective observational study.

Objective: To investigate the relationship between the extent of ligament ossification and the range of motion (ROM) of the lumbar spine and develop a new scoring system.

Methods: Forty-three patients (30 men and 13 women) with lumbar spinal canal stenosis who underwent decompression from January to December 2018. Read More

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Sagittal Deformity Correction in a Patient Suffering From Diffuse Idiopathic Skeletal Hyperostosis Who Previously Underwent a Total Hip and Bilateral Knee Replacement.

Geriatr Orthop Surg Rehabil 2021 11;12:2151459321992745. Epub 2021 Feb 11.

Complejo Hospitalario Universitario de Albacete, Albacete, Spain.

Introduction: Physiological aging frequently leads to degenerative changes and spinal deformity. In patients with hypolordotic fusions or ankylosing illnesses such as diffuse idiopathic skeletal hyperostosis or ankylosing spondylitis, compensation mechanisms can be altered causing severe pain and disability. In addition, if a total hip replacement and/or knee replacement is performed, both pelvic and lower limbs compensation mechanisms could be damaged and prosthetic dislocation or impingement syndrome could be present. Read More

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February 2021

Thoracic spondylotic myelopathy presumably caused by diffuse idiopathic skeletal hyperostosis in a patient who underwent decompression and percutaneous pedicle screw fixation.

SAGE Open Med Case Rep 2021 21;9:2050313X20987796. Epub 2021 Jan 21.

Department of Orthopedic Surgery, Ehime University School of Medicine, Tohon, Japan.

A 74-year-old man developed bilateral lower limb spastic paresis. He was diagnosed with thoracic spondylotic myelopathy presumably caused by mechanical stress that was generated in the intervertebral space (T1-T2) between a vertebral bone bridge (C5-T1) due to diffuse idiopathic skeletal hyperostosis after anterior fixation of the lower cervical spine and a vertebral bone bridge (T2-T7) due to diffuse idiopathic skeletal hyperostosis in the upper thoracic spine. Treatment included posterior decompression (T1-T2 laminectomy) and percutaneous pedicle screw fixation at the C7-T4 level. Read More

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January 2021

Surgical Treatment of Diffuse Idiopathic Skeletal Hyperostosis (DISH) Involving the Cervical Spine: Technical Nuances and Outcome of a Multicenter Experience.

Global Spine J 2021 Feb 16:2192568220988272. Epub 2021 Feb 16.

Department of Neurosurgery, S. Anna University Hospital, Ferrara, Italy.

Study Design: Retrospective multicenter.

Objectives: diffuse idiopathic skeletal hyperostosis (DISH) involving the cervical spine is a rare condition determining disabling aero-digestive symptoms. We analyzed impact of preoperative settings and intraoperative techniques on outcome of patients undergoing surgery for DISH. Read More

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February 2021

Ossification of Posterior Longitudinal Ligament in Cervical Spine and Its Association With Ossified Lesions in the Whole Spine: A Cross-Sectional Study of 2500 CT Scans.

Global Spine J 2021 Feb 11:2192568221993440. Epub 2021 Feb 11.

Orthopaedic and Spine Surgery, Ganga Hospital, Coimbatore, Tamil Nadu, India.

Study Design: A retrospective study.

Objective: To identify the prevalence and characteristics of ossified posterior longitudinal ligament (OPLL) in the cervical spine and its association with other spinal ligament ossifications.

Method: This study is a retrospective review of whole spine CT scans of polytrauma patients from 2009 to 2018. Read More

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February 2021