150,780 results match your criteria Diffuse Axonal Injury Imaging


Hot spots for GPCR signaling: lessons from single-molecule microscopy.

Curr Opin Cell Biol 2018 Dec 3;57:57-63. Epub 2018 Dec 3.

Institute of Pharmacology and Bio-Imaging Center, University of Würzburg, Germany.

G protein-coupled receptors (GPCRs) are among the best-studied membrane receptors, mainly due to their central role in human physiology, involvement in disease and relevance as drug targets. Although biochemical and pharmacological studies have characterized the main steps in GPCR signaling, how GPCRs produce highly specific responses in our cells remains insufficiently understood. New developments in single-molecule microscopy have made it possible to study the protein-protein interactions at the basis of GPCR signaling in previously inconceivable detail. Read More

View Article
December 2018
1 Read

Occurrence and levels of micropollutants across environmental and engineered compartments in Austria.

J Environ Manage 2018 Dec 3;232:636-653. Epub 2018 Dec 3.

Institute for Water Quality and Resource Management, TU Wien, Karlsplatz 13/226, 1040, Vienna, Austria.

Occurrence and concentration of a broad spectrum of micropollutants are investigated in Austrian river catchments, namely polycyclic aromatic hydrocarbons (PAHs), polybrominated diphenyl ethers (PBDEs), organotin compounds, perfluoroalkyl acids (PFAAs) and metals. The parallel analysis across multiple environmental and engineered compartments sheds light on the ratio of dissolved and particulate transport and on differences in concentration levels between point and diffuse emission pathways. It is found that some PAHs and organotins are present in rivers, groundwater and bulk deposition at higher concentrations than in municipal wastewater effluents. Read More

View Article
December 2018
1 Read

Interstitial Lung Disease Onset and Its Risk Factors in Japanese Patients with ALK-positive NSCLC Following Treatment with Crizotinib.

J Thorac Oncol 2018 Dec 3. Epub 2018 Dec 3.

Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.

Introduction: The study objective was to determine the incidence and characteristics of drug-induced interstitial lung disease (ILD) associated with an orally available small-molecule tyrosine kinase inhibitor, crizotinib in the real-world clinical setting.

Methods: Post-marketing surveillance was performed in Japan to obtain information on the safety and efficacy of crizotinib. Target patients included all patients with anaplastic lymphoma kinase-positive non-small cell lung cancer (NSCLC) who received crizotinib, during the enrollment period between May 2012 and December 2014. Read More

View Article
December 2018
4 Reads

Liver transplantation in patients with liver failure related to exertional heatstroke.

J Hepatol 2018 Dec 3. Epub 2018 Dec 3.

AP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, Liver Intensive Care Unit, Villejuif, F-94800, France; INSERM, Unité 1193, Université Paris-Saclay, Villejuif, F-94800, France; DHU Hepatinov, Villejuif, F-94800, France.

Severe acute liver injury (sALI) is a grave complication of exertional heatstroke (EH). Liver transplantation (LT) may be a therapeutic option, but the criteria for, and timing of transplantation have not been clearly established. The aim of this study was to define the profile of patients who require transplantation in this context. Read More

View Article
December 2018
2 Reads

Computer-assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD013186. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Edgbaston Campus, Birmingham, UK, B15 2TT.

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and cutaneous squamous cell carcinoma (cSCC) are high-risk skin cancers which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised with potential to infiltrate and damage surrounding tissue. Anxiety around missing early curable cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Read More

View Article
December 2018
3 Reads

Two Double-hit Lymphomas Cases: A Molecular Cytogenetic Approach.

J Assoc Genet Technol 2018 ;44(4):141-145

Allina Health, Minneapolis, MN.

Objectives: Double-hit lymphomas represent 5% of cases of diffuse large B-cell lymphomas (DLBCL). They are currently recognized as highgrade B-cell lymphomas (HGBCL) with rearrangements of MYC and BCL2 and/or BCL6 by the 2016 WHO classification. One of these rearrangements is the translocation of the BCL2 gene (18q21. Read More

View Article
January 2018
1 Read

On the Electrochemical Degradation of Pt-Ni Nanocatalysts: An Identical Location Aberration-Corrected STEM Study.

Nano Lett 2018 Dec 6. Epub 2018 Dec 6.

The evolution of PtNi nanopartiles supported on amorphous carbon is investigated before and after electrochemical potential cycling (0.6-1.1V), using aberration-corrected STEM and EDS. Read More

View Article
December 2018
1 Read

Methane production and emissions in trees and forests.

New Phytol 2018 Dec 6. Epub 2018 Dec 6.

Smithsonian Environmental Research Center, 647 Contees Wharf Road, Edgewater, MD, 21037.

Forest ecosystem methane (CH ) research has focused on soils, but trees are also important sources and sinks in forest CH budgets. Living and dead trees transport and emit CH produced in soils; living trees and deadwood emit CH produced inside trees by microorganisms; and trees produce CH through an abiotic photochemical process. Here, we review the state of the science on the production, consumption, transport, and emission of CH by living and dead trees, and the spatial and temporal dynamics of these processes across hydrologic gradients inclusive of wetland and upland ecosystems. Read More

View Article
December 2018
1 Read

Diffuse Tibiofemoral Cartilage Change Prior to the Development of Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative.

Clin Anat 2018 Dec 6. Epub 2018 Dec 6.

Division of Rheumatology, Allergy, and Immunology, Tufts Medical Center, Boston, MA, USA.

Introduction: We compared the spatial distribution of tibiofemoral cartilage change between individuals who will develop accelerated knee osteoarthritis (KOA) versus typical onset of KOA prior to the development of radiographic KOA.

Materials And Methods: We conducted a longitudinal case-control analysis of 129 individuals from the Osteoarthritis Initiative. We assessed the percent change in tibiofemoral cartilage on magnetic resonance images at 36 informative locations from two to one year prior to the development of accelerated (n=44) versus typical KOA (n=40). Read More

View Article
December 2018

MDM2 RNA In Situ Hybridization for the Diagnosis of Atypical Lipomatous Tumor: A Study Evaluating DNA, RNA, and Protein Expression.

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Departments of Pathology.

The distinction of atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) from its benign counterpart, lipoma, may represent a challenge. MDM2 DNA amplification is used as the gold standard as MDM2 immunohistochemistry lacks specificity and sensitivity. Herein, we investigate the diagnostic utility of MDM2 RNA in situ hybridization (RNA-ISH) and compare the test with MDM2 immunohistochemistry and MDM2 DNA fluorescence in situ hybridization (FISH) in benign and malignant lipomatous neoplasms. Read More

View Article
December 2018
2 Reads

Optimization of a depth of interaction encoding PET block detector for a PET/MRI insert.

Phys Med Biol 2018 Dec 6;63(23):235031. Epub 2018 Dec 6.

Department of Biomedical Engineering, UC Davis, Davis, California, United States of America. Author to whom any correspondence should be addressed.

Preclinical positron emission tomography, combined with magnetic resonance imaging (PET/MRI), is increasingly used as a tool to simultaneously characterize functional processes in vivo. Many emerging preclinical applications, however, are limited by PET detection sensitivity, especially when generating short imaging frames for quantitative studies. One such application is dynamic multifunctional imaging, which probes multiple aspects of a biological process, using relationships between the datasets to quantify interactions. Read More

View Article
December 2018
1 Read

Portable, low-cost multispectral imaging system: design, development, validation, and utilization.

J Biomed Opt 2018 Dec;23(12):1-11

Tufts University, Biomedical Engineering, Medford, Massachusetts, United States.

Optical spectral images can be used to estimate the amount of bulk absorbers in tissues, specifically oxy- and deoxyhemoglobin, as well as scattering parameters. Most systems that capture spectral image data are large, heavy, and expensive. This paper presents a full end-to-end analysis of a low-cost reflectance-mode multispectral imaging system operating in the visible and near-infrared spectra. Read More

View Article
December 2018
2 Reads

A potential contribution of trappin-2 to the development of vasculopathy in systemic sclerosis.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Background: Trappin-2/pre-elafin is an endogenous inhibitor of human neutrophil elastase involved in inflammation, innate immunity and vascular remodeling, which consist of the complex pathological process of systemic sclerosis (SSc).

Objectives: To clarify the potential role of trappin-2 in SSc.

Methods: Serum trappin-2 levels were determined by enzyme-linked immunosorbent assay in 51 SSc and 18 healthy subjects. Read More

View Article
December 2018
1 Read

Passive sampling of pesticides and polychlorinated biphenyls (PCBs) along the Quequén Grande River watershed (Argentina).

Environ Toxicol Chem 2018 Dec 5. Epub 2018 Dec 5.

Laboratorio de Ecotoxicología y Contaminación Ambiental, Instituto de Investigaciones Marinas y Costeras (IIMyC), Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP) - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Deán Funes 3350, Mar del Plata, 7600, Argentina.

Water monitoring is of great importance, especially for waterbodies in agricultural or industrial areas. Grab sampling is a widely used technique for aquatic monitoring but represents only a snapshot of the contaminant levels at a specific point in time. Passive sampling, on the other hand, is an integrative technique which provides an average concentration of contaminants representative for its deployment period. Read More

View Article
December 2018
1 Read

Phase I/II study of dasatinib and exploratory genomic analysis in relapsed or refractory non-Hodgkin lymphoma.

Br J Haematol 2018 Dec 5. Epub 2018 Dec 5.

Division of Oncology & Hematology, University of Nebraska Medical Center, Omaha, NE, USA.

Relapsed or refractory non-Hodgkin lymphomas (NHLs) often carry poor prognosis and pose management challenges. We evaluated the safety and efficacy of dasatinib, a broad-spectrum multi-kinase inhibitor in relapsed/refractory NHL with correlative genomic analysis in a Phase I/II trial. The study included 33 patients with various sub-types of NHL who had received at least one prior therapy. Read More

View Article
December 2018
3 Reads

Doubling rituximab in high-risk patients with aggressive B-cell lymphoma -results of the DENSE-R-MegaCHOEP trial.

Br J Haematol 2018 Dec 5. Epub 2018 Dec 5.

Department of Haematology, Oncology, Haemostaseology, and Pneumology, University Hospital, Münster, Germany.

To further improve outcome in young high-risk patients with diffuse large B-cell lymphoma (DLBCL) the number of rituximab (R) infusions was doubled in combination with standard CHOEP (cyclophosphamide, doxorubicin, etoposide, vincristine, prednisone) chemotherapy. Seventy-seven patients (aged 18-60 years) with an age-adjusted International Prognostic Index of 2-3 received 12 × R (375 mg/m ) on days 0, 1, 4, 8, 15, 22, 29, 43, 57, 71, 85 and 99 together with eight cycles of CHOEP-14. Results were retrospectively compared to those of patients receiving 6 × R and 8 × CHOEP-14 in the standard arm of the randomized R-MegaCHOEP trial. Read More

View Article
December 2018

Villous lymphocytes in splenic large B-cell lymphoma with diffuse red pulp infiltration.

Int J Hematol 2018 Dec 5. Epub 2018 Dec 5.

Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

View Article
December 2018

Comparison of native myocardial T1 and T2 mapping at 1.5T and 3T in healthy volunteers : Reference values and clinical implications.

Wien Klin Wochenschr 2018 Dec 5. Epub 2018 Dec 5.

Department of Radiology, Paracelsus Medical University, Müllner Hauptstraße 48, 5020, Salzburg, Austria.

Background: Myocardial native T1 and T2 mapping are promising techniques for quantitative assessment of diffuse myocardial pathologies; however, due to conflicting data regarding normal values, routine clinical implementation of this method is still challenging.

Methods: To evaluate this situation during daily clinical practice the characteristics of normal values obtained in 60 healthy volunteers who underwent magnetic resonance imaging (MRI) scans on 1.5T and 3T scanners were studied. Read More

View Article
December 2018
1 Read

CD5 and CD43 Expression are Associate with Poor Prognosis in DLBCL Patients.

Open Med (Wars) 2018 27;13:605-609. Epub 2018 Nov 27.

Department of Internal Medicine 5th Division Jiangxi Cancer Center, Jiangxi Cancer Hospital, Nanchang University, Nanchang, 330029 P.R. China.

Objective: To investigate the expression and clinical significance of CD5 and CD43 in diffuse large B cell lymphoma (DLBCL) (unspecified).

Methods: Sixty - five patients with diagnosed DLBCL were enrolled. The expressions of CD5, CD43, CD10, Bcl-6 and Mun-1 were detected by immuno histochemistry. Read More

View Article
November 2018

Pleural anthracosis presenting with massive effusion: a rare entity.

Respirol Case Rep 2019 Feb 28;7(2):e00390. Epub 2018 Nov 28.

Respiratory Department Universiti Kebangsaan Malaysia Medical Centre Kuala Lumpur Malaysia.

Pleural anthracosis is rare and, in most cases, is diagnosed incidentally or at autopsy. We report a 67-year-old man with pleural anthracosis. He was initially referred for possible tuberculous pleural effusion and had recurrent admissions for symptomatic pleural effusion, which increased with each subsequent episode. Read More

View Article
February 2019

Coexistent sarcoidosis and lymphangioleiomyomatosis in a patient with cystic lung disease.

Respirol Case Rep 2019 Feb 28;7(2):e00389. Epub 2018 Nov 28.

Department of Respiratory Medicine Cork University Hospital Ireland.

A 45-year-old lady presented acutely with pleuritic chest pain, haemoptysis, and dyspnoea. Her background was significant for a 1.4 cm renal angiomyolipoma, and she was an ex-smoker without any relevant family history. Read More

View Article
February 2019

Inhibition or Stimulation of Ochratoxin A Synthesis on Inoculated Barley Triggered by Diffuse Coplanar Surface Barrier Discharge Plasma.

Front Microbiol 2018 16;9:2782. Epub 2018 Nov 16.

Leibniz Institute for Agricultural Engineering and Bioeconomy, Quality and Safety of Food and Feed, Potsdam, Germany.

Ochratoxin A (OTA) is one of the most abundant food-contaminating mycotoxins. Besides their high toxicity, mycotoxins are highly stable to physical, chemical or biological detoxification. Therefore, the treatment with cold atmospheric plasma could be one approach to reduce the amount of mycotoxins in different products. Read More

View Article
November 2018

Diagnosis, Clinical Trend, and Treatment of Diffuse Lamellar Keratitis after Femtosecond Laser-Assisted in situ Keratomileusis: A Case Report.

Case Rep Ophthalmol 2018 Sep-Dec;9(3):457-464. Epub 2018 Nov 14.

Balestrazzi Associated Ophthalmological Practice, Rome, Italy.

We report a severe case of diffuse lamellar keratitis (DLK) following femtosecond laser-assisted in situ keratomileusis (femto-LASIK). A 25-year-old man was submitted to 150 kHz iFS® IntraLase-assisted LASIK in both eyes for compound myopic astigmatism. The day after surgery, clinical examination showed a diffuse whitish granular cell reaction particularly in the right eye. Read More

View Article
November 2018
5 Reads

The Wrong Turn to Tijuana: Dry Beriberi after Gastric Bypass Surgery with Incidental Spinal Stenosis.

Case Rep Neurol 2018 Sep-Dec;10(3):309-313. Epub 2018 Nov 8.

Internal Medicine, Mount Carmel West Hospital, Columbus, Ohio, USA.

Thiamine deficiency is a condition characterized by several different presentations, but one of the most devastating is dry beriberi. It is associated with polyneuropathy and muscle weakness which typically affects the lower extremities and progressively involves the upper extremities. This case outlines a case of a 41-year-old man that presented to the hospital with diffuse weakness and decreased sensation in his legs and hands over a 3-day period. Read More

View Article
November 2018
4 Reads

Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial.

Lancet Oncol 2018 Nov 30. Epub 2018 Nov 30.

University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Axicabtagene ciloleucel is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy. In the previous analysis of the ZUMA-1 registrational study, with a median follow-up of 15·4 months (IQR 13·7-17·3), 89 (82%) of 108 assessable patients with refractory large B-cell lymphoma treated with axicabtagene ciloleucel achieved an objective response, and complete responses were noted in 63 (58%) patients. Here we report long-term activity and safety outcomes of the ZUMA-1 study. Read More

View Article
November 2018

The Disease Phenotype of Adenomyosis-Affected Women Correlates With Specific Serum Cytokine Profiles.

Reprod Sci 2018 Dec 5:1933719118816852. Epub 2018 Dec 5.

1 Department of Gynaecology Obstetrics II and Reproductive Medicine, Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Universitaire Paris Centre, Centre Hospitalier Universitaire (CHU) Cochin, Paris, France.

Background:: Adenomyosis (ADE) is an enigmatic uterine disorder. Several types have been previously described: diffuse adenomyosis (DIF-ADE), focal adenomyosis (FOC-ADE), and association of focal and diffuse lesions (FOC/DIF-ADE). Abnormal immune phenomena have been described that may provide an understanding of the pathophysiology of adenomyosis. Read More

View Article
December 2018
2 Reads

[Diagnosis and Treatment of Interstitial Lung Diseases].

Dtsch Med Wochenschr 2018 Dec 3;143(24):1774-1777. Epub 2018 Dec 3.

Klinik Schillerhöhe, Abteilung für Pneumologie und Beatmungsmedizin, Gerlingen, Robert-Bosch-Krankenhaus.

Interstitial lung diseases compromise a group of diffuse predominantly chronic inflammatory and fibrosing disorders of the lung parenchyma. This article reviews practice-relevant publications on the diagnosis and treatment of idiopathic pulmonary fibrosis - the most common form of idiopathic interstitial lung diseases. The new patient questionnaire of the German Society of Pneumology facilitates collection of a complex case history of diverse interstitial lung diseases in individual patients. Read More

View Article
December 2018

Interstitial lung disease associated with nanoparticle albumin-bound paclitaxel treatment in patients with lung cancer.

Jpn J Clin Oncol 2018 Dec 1. Epub 2018 Dec 1.

Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Background: Nanoparticle albumin-bound paclitaxel is indicated for the treatment of patients with lung cancer. It can induce interstitial lung disease, but the incidence of nanoparticle albumin-bound paclitaxel-associated interstitial lung disease in clinical practice has not been determined. We investigated the incidence of interstitial lung disease in patients with lung cancer who had received nanoparticle albumin-bound paclitaxel therapy at our institution. Read More

View Article
December 2018

Serum biomarkers of collagen turnover as potential diagnostic tools in diffuse systemic sclerosis: A cross-sectional study.

PLoS One 2018 3;13(12):e0207324. Epub 2018 Dec 3.

Clinical Development, Biogen, Cambridge, Massachusetts, United States of America.

Background: Systemic sclerosis (SSc) is characterized by excessive fibrosis throughout the body. This leads to the release of extracellular matrix (ECM) fragments into circulation, where they may be quantified as biomarkers. The objectives were to investigate levels of ECM turnover biomarkers and the diagnostic power of these. Read More

View Article
December 2018

Diffuse gingival enlargement: an unusual diagnostic clue for pulmonary tuberculosis.

Lancet Infect Dis 2018 Nov 24;18(11):1288. Epub 2018 Oct 24.

Department of Pathology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.

View Article
November 2018

Pleural Effusions in Diffuse Large B-Cell Lymphoma: Clinical and Prognostic Significance.

Lung 2018 Nov 30. Epub 2018 Nov 30.

Pleural Medicine Unit, Department of Internal Medicine, Arnau de Vilanova University Hospital, IRBLleida, Lleida, Spain.

Purpose: Pleural effusion (PEs) may complicate diffuse large B-cell lymphomas (DLBCL). However, their real prevalence and prognostic significance have seldom been approached systematically.

Methods: Retrospective single-center evaluation of consecutive patients with DLBCL was conducted. Read More

View Article
November 2018

Spontaneous Silver Doping and Surface Passivation of CsPbI Perovskite Active Layer Enable Light-Emitting Devices with an External Quantum Efficiency of 11.2.

ACS Energy Lett 2018 Jul 13;3(7):1571-1577. Epub 2018 Jun 13.

Department of Materials Science and Engineering, and Centre for Functional Photonics (CFP), City University of Hong Kong, Kowloon, Hong Kong SAR.

Lead halide perovskite nanocrystals are currently under intense investigation as components of solution-processed light-emitting devices (LEDs). We demonstrate LEDs based on Ag doped-passivated CsPbI perovskite nanocrystals with external quantum efficiency of 11.2% and an improved stability. Read More

View Article

Diffuse Cutaneous Leishmaniasis in an Immunocompromised Patient Resembling Histoid Hansen's Disease.

Indian Dermatol Online J 2018 Nov-Dec;9(6):452-454

Department of Dermatology, Venereology and Leprology, RNT Medical College, Udaipur, Rajasthan, India.

Cutaneous leishmaniasis is caused by protozoan parasites of the genus . Atypical presentation and widespread progression of the lesions may be seen in patients with HIV disease and diffuse cutaneous leishmaniasis and HIV co-infection is emerging as a serious new threat. We report a case of diffuse cutaneous leishmaniasis in a HIV- infected patient resembling Histoid Hansen. Read More

View Article
December 2018
1 Read

A case of sinobronchial syndrome progressing to diffuse panbronchiolitis despite low-dose, long-term macrolide therapy.

J Thorac Dis 2018 Oct;10(10):E727-E729

Department of Hematology/Respiratory-Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, Japan.

View Article
October 2018

An unusual complication of pigtail catheter insertion.

J Thorac Dis 2018 Oct;10(10):5964-5967

Department of Pulmonary/Critical Care, Staten Island University Hospital, Staten Island, New York, USA.

Thoracostomy tubes are indicated for management of air or fluid in the pleural cavity. Pigtail catheters have emerged as an effective and less morbid alternative to traditional large bore chest tubes for evacuation of pleural air or fluid. However, they do not come without complications which commonly include pneumothorax and hemothorax. Read More

View Article
October 2018

The Prevalence of Cervical Foraminal Stenosis on Computed Tomography of a Selected Community-Based Korean Population.

Clin Orthop Surg 2018 Dec 21;10(4):433-438. Epub 2018 Nov 21.

Department of Orthopaedic Surgery, Daegu Catholic University Medical Center, Daegu, Korea.

Background: Cervical foraminal stenosis (CFS) is one of the degenerative changes of the cervical spine; however, correlations between the severity of stenosis and that of symptoms are not consistent in the literature. Studies to date on the prevalence of stenosis are based on images obtained from the departments treating cervical lesions, and thus patient selection bias may have occurred. The purpose of this study was to investigate the prevalence of CFS according to the site, extent, and morphology of stenosis using cervical computed tomography (CT) images obtained from patients who were visiting not because of symptoms related to the cervical spine, cervical pain, or upper limb pain. Read More

View Article
December 2018

False-positive technetium-99m methylene diphosphonate bone scan activity in the orbit in a patient with a history of breast carcinoma.

World J Nucl Med 2018 Oct-Dec;17(4):299-301

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA.

Metastasis of breast carcinoma to the orbit is an uncommon entity and carries a poor prognosis. This case report presents false-positive technetium-99m methylene diphosphonate activity in the right orbit of a patient with a history of a primary breast neoplasm. Orbital computed tomography imaging was obtained to further characterize the radiotracer uptake identified on the bone scan and demonstrated diffuse right globe intraocular calcifications secondary to degenerative intraocular changes. Read More

View Article
December 2018

Scintigraphic evaluation of colonic transit in children with constipation using Ga-citrate.

World J Nucl Med 2018 Oct-Dec;17(4):249-252

Hospital de Base do Distrito Federal - Nuclear Medicine Service, Brasília, Brasil.

The aim of this study was to assess the colonic transit in children and teenagers with chronic constipation. Twenty patients from 1.5 to 16 years old were included (mean age = 6. Read More

View Article
December 2018

Treatment before macular grid in patients of diabetic macular edema.

Oman J Ophthalmol 2018 Sep-Dec;11(3):254-258

Department of Biostatistics, Dr. R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Aim: The aim of this study is to compare the efficacy of intravitreal bevacizumab and posterior subtenons triamcinolone acetate in the management of diffuse diabetic macular edema (DME) and to evaluate their efficacy as an adjunct to modified grid laser in management of DME.

Design: This was a prospective, randomized clinical trial of 30 patients.

Materials And Methods: A total of 30 patients attending the medical ophthalmology clinic at a tertiary care hospital were included in the study. Read More

View Article
December 2018

Evaluation of intravitreal bevacizumab as monotherapy and in combination with macular grid laser photocoagulation in diffuse diabetic macular edema.

Oman J Ophthalmol 2018 Sep-Dec;11(3):248-253

Department of Ophthalmology, University College of Medical Sciences and GTB Hospital, Delhi University, New Delhi, India.

Background And Objective: The objective of the study was to compare the efficacy of intravitreal bevacizumab (IVB) as monotherapy versus combination with modified macular grid (MMG) laser photocoagulation in the primary treatment of diffuse diabetic macular edema (DDME).

Materials And Methods: A prospective randomized trial was carried out in sixty eyes with DDME after Institutional Ethical clearance. Group A received three doses of IVB at a 1-month interval. Read More

View Article
December 2018

Functioning in the emotional sphere and ways of coping with chronic connective tissue disease.

Reumatologia 2018 31;56(5):321-327. Epub 2018 Oct 31.

Department of Integrated Medical Care, Medical University of Białystok, Poland.

Chronic illness is a strong stressor, and its occurrence in human life forces the individual to make adaptive changes. The aim of the study was to evaluate the reactions, behaviors, and emotional states of a person in the face of systemic connective tissue disease and ways of coping with this difficult situation. The method of choice was an individual case study. Read More

View Article
October 2018

Median neuropathy at the wrist in patients with systemic sclerosis: two-year follow-up study.

Reumatologia 2018 31;56(5):294-300. Epub 2018 Oct 31.

Department of Rehabilitation Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Objectives: To determine the incidence and factors associated with median neuropathy at the wrist (MNW) in systemic sclerosis (SSc) patients using an electrodiagnostic (EDX) study.

Material And Methods: SSc patients who attended the scleroderma clinic, Srinagarind Hospital, were prospectively evaluated by questionnaire, physical examination, and EDX study. The questionnaire consisted of the baseline characteristics, type of scleroderma, clinical signs and symptoms associated with scleroderma, and the Boston questionnaire. Read More

View Article
October 2018

Infantile Hepatic Hemangioma.

J Pak Med Assoc 2018 Dec;68(12):1846-1847

Department of Radiology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.

Infantile hepatic hemangioma (IHH) historically called "hemangiomaendothelioma" refers to visceral manifestation of infantile hemangioma. The diagnosis of infantile hepatic hemangioma is primarily based on the radiological features. We present a case of 4 month old infant who presented with abdominal distention. Read More

View Article
December 2018
1 Read

[Optimization of Nasal Drug Absorption from Powder Formulations: The Feasibility of Controlling Drug Absorption by the Use of Pharmaceutical Excipients].

Authors:
Akiko Tanaka

Yakugaku Zasshi 2018 ;138(12):1467-1472

Department of Biopharmaceutics, Kyoto Pharmaceutical University.

Nasal application of powder formulations has garnered attention because of its significant potential for systemic drug delivery. Because a powder drug must first diffuse from the formulation and dissolve in the nasal cavity fluid before transepithelial permeation, dissolution and diffusion are distinct but important factors for nasal drug absorption. Since the formulation is directly administered onto the nasal mucosal surface, the effect of excipients on drug absorption may be significant. Read More

View Article
January 2018

Autopsy in dengue encephalitis: An analysis of three cases.

Neurol India 2018 Nov-Dec;66(6):1721-1725

Department of Pathology and Neurology, Command Hospital Air Force, Bengaluru, Karnataka, India.

Dengue viral infection with unusual presentations has been described in literature, but autopsy is rarely done and is only limited to some cases, based on the literature review. Here, we present the autopsy findings in three cases of dengue encephalitis. All the three patients clinically presented with signs of meningoencephalitis and were positive for dengue non-structural (NS) 1 antigen (Ag) in the serum and cerebrospinal fluid. Read More

View Article
December 2018

Developmental venous anomaly in adult patients with diffuse glioma: A clinically relevant coexistence?

Neurology 2018 Nov 30. Epub 2018 Nov 30.

From the Departments of Neurosurgery (A.R., M.Z., E.D., G.Z.-B., J.P.), Neuroradiology (M.E., S. Porelli, C.O), and Neuropathology (A.T.-E., P.V.), Sainte-Anne Hospital; Paris Descartes University (A.R., M.E., S. Porelli, A.T.-E., M.Z., E.D., G.Z.-B., S. Puget, P.V., C.O., J.P.), Sorbonne Paris Cité; Inserm (A.R., M.E., M.Z., E.D., P.V., C.O., J.P.), U894, IMA-Brain, Centre Psychiatrie et Neurosciences; Departments of Neuro-oncology (M.S.) and Neurosurgery (L.C.), Pitié-Salpêtrière Hospital; and Department of Pediatric Neurosurgery (S. Puget), Necker Hospital, Paris, France.

Objective: To determine the prevalence of developmental venous anomaly in adult patients with diffuse glioma.

Methods: We performed a retrospective cohort study (2010-2016) of consecutive adult patients harboring a supratentorial diffuse glioma in 2 centers: Sainte-Anne Hospital (experimental and control sets) and Pitié-Salpêtrière Hospital (external validation set). We included 219 patients with diffuse glioma (experimental set), 252 patients with brain metastasis (control set), and 200 patients with diffuse glioma (validation set). Read More

View Article
November 2018
5 Reads