Stroke 2022 03 27;53(3):808-816. Epub 2021 Oct 27.
Vanderbilt Memory & Alzheimer's Center (E.E.M., N.S., K.R.P., D.L., K.A.G., T.J.H., A.L.J.), Vanderbilt University Medical Center, Nashville, TN.
Background And Purpose: Left ventricular (LV) mass index is a marker of subclinical LV remodeling that relates to white matter damage in aging, but molecular pathways underlying this association are unknown. This study assessed if LV mass index related to cerebrospinal fluid (CSF) biomarkers of microglial activation (sTREM2 [soluble triggering receptor expressed on myeloid cells 2]), axonal injury (NFL [neurofilament light]), neurodegeneration (total-tau), and amyloid-β, and whether these biomarkers partially accounted for associations between increased LV mass index and white matter damage. We hypothesized higher LV mass index would relate to greater CSF biomarker levels, and these pathologies would partially mediate associations with cerebral white matter microstructure. Read More