12,141 results match your criteria Die Pharmazie[Journal]


Relationship between the administration of nicardipine hydrochloride and the development of delirium in patients on mechanical ventilation.

Pharmazie 2018 Dec;73(12):740-743

A history of hypertension is a known risk factor for delirium in patients in intensive care units, but the effect of antihypertensive agents on delirium development is unclear. Nicardipine, a calcium channel blocker, is widely used in ICU as a treatment agent for hypertensive emergency. This study investigated the relationship between the administration of nicardipine hydrochloride and delirium development in patients under mechanical ventilation. Read More

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http://dx.doi.org/10.1691/ph.2018.8711DOI Listing
December 2018

Applicability of hemodialysis clearance parameter for vancomycin therapeutic drug monitoring during continuous hemodiafiltration in an infant.

Pharmazie 2018 Dec;73(12):737-739

Cases requiring vancomycin administration planning in infants undergoing continuous hemodiafiltration (CHDF) are extremely rare. Here, we report a single case in which vancomycin therapeutic drug monitoring and administration planning were implemented for an infant requiring CHDF. The patient was diagnosed with wound infection after gastrostomy and enterotomy surgery and received vancomycin treatment for infection with methicillin-resistant . Read More

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http://dx.doi.org/10.1691/ph.2018.8748DOI Listing
December 2018

Antiviral activity of propolis special extract GH 2002 against virus .

Pharmazie 2018 Dec;73(12):733-736

Propolis is a generic name for a biological substance produced by bees used for multiple purposes in folk medicine. Propolis special extract GH 2002 is crude propolis highly purified by a special procedure and freed from the accompanying substances like pollen, wax, resins. The cytotoxic and antiherpetic effect of propolis extracts against virus (VZV) was analysed in cell culture, and revealed a moderate cytotoxicity on lung fibroblasts with a CC of 380 μg/ml. Read More

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http://dx.doi.org/10.1691/ph.2018.8672DOI Listing
December 2018

Retinoic acid increases the anticancer effect of paclitaxel by inducing differentiation of cancer stem cells in melanoma.

Authors:
Y B Wang B Sun B Han

Pharmazie 2018 Dec;73(12):729-732

Malignant melanoma is a highly lethal disease, and advanced stages of melanoma have proven to be resistant to many chemotherapeutic drugs including temozolomide and paclitaxel. Cancer stem cells (CSCs) have been identified and isolated in different cancers including melanoma, and have been proven playing important role in the drug resistance. Retinoic acid (RA) is a promising anticancer agent, which can induce differentiation of CSCs. Read More

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http://dx.doi.org/10.1691/ph.2018.8715DOI Listing
December 2018

High glucose induces the apoptosis of HUVECs in mitochondria dependent manner by enhancing VDAC1 expression.

Pharmazie 2018 Dec;73(12):725-728

Mellithemia are diabetic patients' emblematic syndrome, which would induce vasculopathy resulting from apoptosis of vascular endothelial cells. The pathological mechanism of high glucose-induced apoptosis of vascular endothelial cells is investigated in the present study utilizing HUVEC cells. As high glucose-induced apoptosis is caused by elevated mitochondrial permeability-mediated release of mitochondrial cytochrome c, voltage-dependent anion channel (VDAC1), the controller of mitochondrial permeability, and its regulator Bax were investigated. Read More

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http://dx.doi.org/10.1691/ph.2018.8544DOI Listing
December 2018

Walnut oil promotes healing of wounds and skin defects in rats regulating the NF-kB pathway.

Pharmazie 2018 Dec;73(12):721-724

The effects of walnut oil on wound healing and skin injury repair was observed in Sprague-Dawley (SD) rats, and mechanism of action was investigated. Normal SD rats were divided into an experimental group and a control group. Each group was observed at4 time points (day [D]3, D7, D14, and D21). Read More

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http://dx.doi.org/10.1691/ph.2018.8605DOI Listing
December 2018

A cell-internalizing peptide endows tumstatin7 with enhanced antitumor properties.

Pharmazie 2018 Dec;73(12):715-720

Tumstatin7 (CNYYSNS) is an antitumor peptide derived from the NC1 domain of Type IV collagen that has been associated with tumor angiogenesis. In this work, we generated a peptide composed of tumstatin7 fused to TAT, a cell-internalizing peptide consisting of 11 amino acids. Tumstatin7-TAT was internalized by cells and triggered cell death. Read More

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http://dx.doi.org/10.1691/ph.2018.8623DOI Listing
December 2018

Loss of miR-217 promotes osteosarcoma cell proliferation through targeting SETD8.

Pharmazie 2018 Dec;73(12):711-714

Recently, many kinds of microRNAs (miRNAs) have been found to play a critical role in progression of osteosarcoma (OS). miR-217 was reported to function as a tumor suppressor in a number of human cancers but its precise mechanism to exert the suppressive role remains to be investigated. In this study, we found that miR-217 was downregulated in OS tissues and its downregulation predicts poor overall survival of OS patients. Read More

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http://dx.doi.org/10.1691/ph.2018.8644DOI Listing
December 2018

The anti-apoptotic effect of nerve growth factor on propofol-induced neurotoxicity in hippocampal neurons is Rac1 dependent.

Pharmazie 2018 Dec;73(12):706-710

Propofol has been considered as a near-ideal anesthetic agent since its introduction 40 years ago. However, the side effects of propofol including bacterial contamination, hyperlipidemia, and neurotoxicity also aroused attention. Nerve growth factor (NGF) plays a pivotal role in the development, differentiation, and survival of the neurons of the peripheral and central nervous system. Read More

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http://dx.doi.org/10.1691/ph.2018.8726DOI Listing
December 2018

Functional expression of breast cancer resistance protein and cholesterol effect in human erythrocyte membranes.

Pharmazie 2018 Dec;73(12):700-705

In human erythrocyte membranes, various influx and efflux transporters are functionally expressed. However, their transport characteristics and modulation under disease states are not fully understood. In this study, we first examined the expression and detailed transport characteristics of breast cancer resistance protein (BCRP), an efflux ABC transporter, using inside-out membrane vesicles (IOVs) prepared from human erythrocytes, and then studied the effect of membrane cholesterol on BCRP function. Read More

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http://dx.doi.org/10.1691/ph.2018.8724DOI Listing
December 2018

GLP-1 attenuates Ang II-induced proliferation and migration in rat aorta smooth muscle cells inhibition of the RhoA/ROCK2 signaling pathway.

Pharmazie 2018 Dec;73(12):692-699

Glucagon-like peptide 1 (GLP-1), a neuroendocrine hormone produced by the gastrointestinal tract, plays a significant role in blood glucose regulation; drugs derived from GLP-1 are currently used for the treatment of type 2 diabetes. In addition to regulating glucose homeostasis, the protective effects of GLP-1 on the cardiovascular system are also of interest. However, the vascular protective mechanisms of GLP-1 remain unclear. Read More

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http://dx.doi.org/10.1691/ph.2018.8693DOI Listing
December 2018

Bioavailability of propylthiouracil from two formulation tablets.

Pharmazie 2018 Dec;73(12):688-691

Bioavailability studies were performed for 50 mg propylthiouracil tablets (Jelfa, Poland) 50 mg propycil tablets (Solvay, Germany). An open-label, two-phase, crossover study was conducted with 15 healthy subjects. All subjects were randomly assigned a drug assignment number from I to XV, which was used throughout the experimental period. Read More

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http://dx.doi.org/10.1691/ph.2018.8552DOI Listing
December 2018

Quality control of hospital preparations: Establishment of a simple and rapid method for quantifying ulinastatin in vaginal suppositories.

Pharmazie 2018 Dec;73(12):683-687

Ulinastatin vaginal suppositories, used to prevent threatened premature delivery, are frequently used in hospitals. However, there is no established method for quantifying ulinastatin contained in suppositories. Therefore, we investigated a simple and efficient method for quantifying ulinastatin contained in suppositories. Read More

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http://dx.doi.org/10.1691/ph.2018.8069DOI Listing
December 2018

Cleopatra: from turpentine and juniper to ionone and irone.

Pharmazie 2018 Nov;73(11):676-680

Cleopatra VII (69-30 BC), the last Ptolemaic ruler of Egypt, is probably best known for her love affairs with Julius Caesar (100-44 BC) and Marcus Antonius (83-30 BC). Rightly or wrongly she became the epitome of shrewd seduction, leading brave Roman commanders on a path to debauchery and destruction. Among the seductive strategies attributed to her is the ingestion of small amounts of turpentine [the resin of the terebinth tree ()] or of derived oil () with the purpose of conferring to her urine a more pleasant scent reminding of violets. Read More

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http://dx.doi.org/10.1691/ph.2018.8142DOI Listing
November 2018
4 Reads

Risk factors increasing blood pressure in Japanese colorectal cancer patients treated with bevacizumab.

Pharmazie 2018 Nov;73(11):671-675

Bevacizumab has been reported to increase blood pressure. However, the factors, including patient characteristics and laboratory data contributing to this side effect remain unclear. Therefore, we investigated the relationships between increased blood pressure and bevacizumab administration, patient characteristics, and laboratory data. Read More

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http://dx.doi.org/10.1691/ph.2018.8664DOI Listing
November 2018
2 Reads

Protective effects and possible molecular mechanism of Thunb. extract on acetaminophen-induced hepatotoxicity.

Pharmazie 2018 Nov;73(11):666-670

Thunb. is a traditional hepatoprotective Chinese medicine, and in research, much effort has been focused on the protection against alcoholic liver injury. In this study, the protective effects of a fruit ethanol extract of (FE) against APAP-induced acute hepatotoxicity in mice and the possibly involved molecular mechanisms were investigated. Read More

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http://dx.doi.org/10.1691/ph.2018.8650DOI Listing
November 2018
5 Reads

High expression of TAZ/YAP promotes the progression of malignant melanoma and affects the postoperative survival of patients.

Pharmazie 2018 Nov;73(11):662-665

YAP/TAZ have been reported to be highly expressed in malignant tumors. This research was aimed to study the expression of TAZ/YAP protein in malignant melanoma and to investigate its relationship to the clinicopathology and prognosis of patients with malignant melanoma. A total of 156 pairs of malignant melanoma tumor tissues and melanocytic nevi tissues were collected. Read More

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http://dx.doi.org/10.1691/ph.2018.8499DOI Listing
November 2018
2 Reads

Analgesic effects of the novel α₂δ ligand mirogabalin in a rat model of spinal cord injury.

Pharmazie 2018 Nov;73(11):659-661

Mirogabalin, which is a novel ligand for the α₂δ subunit of voltage-gated calcium channels, is under development for the treatment of pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Mirogabalin possesses unique binding characteristics to α₂δ subunits and potent and long-lasting analgesic effects in peripheral neuropathic pain models. In the present study, we investigated the analgesic effects of mirogabalin in a rat model of spinal cord injury as an experimental animal model for central neuropathic pain. Read More

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http://dx.doi.org/10.1691/ph.2018.8550DOI Listing
November 2018
11 Reads

Pterostilbene's protective effects against photodamage caused by UVA/UVB irradiation.

Pharmazie 2018 Nov;73(11):651-658

The aim of this study was to further elucidate the mechanism of pterostilbene against UVA/UVB irradiation and the Nuclear factor E2-related factor 2 (Nrf2) signal pathway. A photo-damage model with UVA/UVB irradiation in HaCat cells was established and used in this study. The dose of pterostilbene was selected through MTS assay. Read More

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http://dx.doi.org/10.1691/ph.2018.8598DOI Listing
November 2018

Effects of dexmedetomidine, propofol and etomidate on the intraoperative wake-up in the cerebral functional area under the guidance of entropy index.

Pharmazie 2018 Nov;73(11):647-650

The study observed the efficacy and safety of dexmedetomidine, propofol and etomidate on brain functional areas in patients undergoing wake-up brain surgery under the guidance of entropy index. Sixty patients undergoing wake-up brain surgery on brain functional areas were enrolled, and randomly divided into three groups: dexmedetomidine group (group D), propofol group (group P) and etomidate group (group E), 20 in each. The vital signs, entropy indices of each time point, wake-up time, wake-up quality and adverse reaction in the wake-up period were observed and compared. Read More

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http://dx.doi.org/10.1691/ph.2018.8613DOI Listing
November 2018

Levetiracetam inhibits endocytosis and augments short-term depression.

Authors:

Pharmazie 2018 Nov;73(11):643-646

Levetiracetam (LEV) is an anti-epileptic drug with demonstrated efficacy against generalized seizures. Recent studies have found that LEV affects the release of neurotransmitters by binding to synaptic vesicle protein 2A (SV2A). However, the details of LEV regulation of synaptic transmission remain poorly understood. Read More

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http://dx.doi.org/10.1691/ph.2018.8634DOI Listing
November 2018
1 Read

Drug likeness, targets, molecular docking and ADMET studies for some indolizine derivatives.

Authors:
A Belal

Pharmazie 2018 Nov;73(11):635-642

The aim of this work was to investigate the biomolecular targets for a library of indolizines, study their molecular properties, drug likeness, target prediction, performing docking studies and exploring their ADMET profile in search for a lead compound. All compounds appeared to comply with Lipinski's rule without any violation, additionally their solubility is viewed good except for compounds which are anticipated to be reasonably soluble, their Milog P score was 4.18-4. Read More

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http://dx.doi.org/10.1691/ph.2018.8061DOI Listing
November 2018

An UPLC-MS/MS method for the determination of EAI045 in plasma and tissues and its application to pharmacokinetic and distribution studies in rats.

Pharmazie 2018 Nov;73(11):630-634

EAI045 represents a fourth generation allosteric EGFR TKI compound which targets and EGFR mutants. The study reported herein describes a method to explore the distribution of EAI045 in rat tissues as well as to quantify it in plasma. The method used here is an ultra-performance liquid chromatography-tandem mass spectrometry with high sensitivity and selectivity. Read More

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http://dx.doi.org/10.1691/ph.2018.8123DOI Listing
November 2018
8 Reads
1.003 Impact Factor

A simple and sensitive HPLC-fluorescence method for the determination of moxifloxacin in human plasma and its application in a pharmacokinetic study.

Pharmazie 2018 Nov;73(11):625-629

A simple sample preparation technique coupled with the specific and sensitive fluorescence detection for the determination of moxifloxacin in human plasma was developed and fully validated. Levofloxacin was chosen as an internal standard. Chromatographic separation was achieved using a Shiseido C18 MGII (250×4. Read More

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http://dx.doi.org/10.1691/ph.2018.8148DOI Listing
November 2018
4 Reads

CYP2C19 polymorphism in relation to the pharmacotherapy optimization of commonly used drugs.

Pharmazie 2018 Nov;73(11):619-624

: The CYP2C19 isoenzyme plays an important role in the efficacy and safe use of many drugs. The aim of this review is to demonstrate how mutations influence everyday patient treatment, leading to adverse drug reactions or therapy failure in many common diseases. : A PubMed literature search was performed on clinical publications evaluating the impact of on pharmacotherapy outcome. Read More

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http://dx.doi.org/10.1691/ph.2018.8689DOI Listing
November 2018
9 Reads

Clinic-level factors associated with collaboration with community pharmacies in Japan.

Pharmazie 2018 09;73(9):545-552

The aim of this study was to clarify the clinic-level factors related to experiences of and attitudes toward collaboration with community pharmacies. We conducted a postal questionnaire survey of all clinics in Gifu, Japan, assessing the experiences and attitudes of representative clinical staff regarding the following activities in collaboration with community pharmacists: regional care meetings/service adjustment meetings, case study conferences, joint workshops/continuing education conferences, community services, information sharing through medical cooperation networks, and accompanying community pharmacists during home care. The factors significantly related to experiences of joint workshops/continuing education conferences included home care visits (odds ratio [OR] 2. Read More

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http://dx.doi.org/10.1691/ph.2018.8542DOI Listing
September 2018

Anti-inflammatory effects of neferine on LPS-induced human endothelium MAPK, and NF-κβ pathways.

Pharmazie 2018 09;73(9):541-544

This study aimed to evaluate the anti-inflammatory mechanism of neferine, a bisbenzylisoquinoline alkaloid, on the lipopolysaccharide (LPS)-induced inflammation in Human Umbilical Endothelial Cells (HUVECs) and pulmonary aorta cells. Production of pro-inflammatory cytokines and nitric oxide (NO) was determined using Griess reaction in human endothelial cells. The levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and mitogen-activated protein kinases (MAPKs) were analyzed using real time PCR and western blotting. Read More

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http://dx.doi.org/10.1691/ph.2018.8443DOI Listing
September 2018

Attenuation of pro-inflammatory cytokines and oxidative stress by misoprostol in renal ischemia/reperfusion in rats.

Pharmazie 2018 09;73(9):537-540

The ischemia/reperfusion (I/R) process alters metabolic pathways, releasing reactive oxygen species and pro-inflammatory cytokines that cause tissue necrosis and activate cellular apoptotic pathways. Misoprostol (MSP) is a prostaglandin E1 analog that has demonstrated a cytoprotective role in the I/R process. The study objective was to evaluate the effects of MSP on the regulation of pro-inflammatory and oxidative stress mediators in an I/R-induced acute kidney injury rat model. Read More

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http://dx.doi.org/10.1691/ph.2018/8498DOI Listing
September 2018

HIF-1α-induced autophagy contributes to cisplatin resistance in ovarian cancer cells.

Pharmazie 2018 09;73(9):533-536

In this study, the viability and apoptosis of ovarian cancer cell line OVCAR-3 were assessed using MTT and flow cytometry analysis. GFP-tagged LC3 plasmid transfection was utilized to demonstrate the occurrence of autophagy. The expression of HIF-1α, Beclin1, LC3 and β-actin were determined with Western blot analysis. Read More

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http://dx.doi.org/10.1691/ph.2018.8514DOI Listing
September 2018
1 Read

Therapeutic potential of artesunate in experimental autoimmune myasthenia gravis by upregulated T regulatory cells and regulation of Th1/Th2 cytokines.

Pharmazie 2018 09;73(9):526-532

Artesunate is a semi-synthetic derivative of a Chinese herb named Artemisia annua L. that is commonly used as an antimalarial agent in the history of traditional Chinese medicine. Many studies have reported artesunate possesses anti-inflammatory and immunoregulation properties. Read More

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http://dx.doi.org/10.1691/ph.2018.8516DOI Listing
September 2018
5 Reads

Effect of miR-433-3p and miR-883b-5p on murine CYP 3A family enzymes in AML12 cells.

Authors:
Y Sugino F Kugawa

Pharmazie 2018 09;73(9):519-525

Here we searched for microRNAs that could interact with cytochrome P450 (CYP) enzymes in silico, and then investigated their effects on Cyp gene expressions using the cultured mouse liver cell line AML12. Among the mouse Cyp3a genes, some miRNAs were found to interact with Cyp3a11, 13, 16, and 44 by the in silico analysis using the miRWalk2.0 database. Read More

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http://dx.doi.org/10.1691/ph.2018.8530DOI Listing
September 2018
7 Reads

Downregulation of microRNA-128-3p protects human esophageal squamous Het-1A cells from hydrochloric acid-induced cell injury by targeting E2F3.

Pharmazie 2018 09;73(9):513-518

This study aimed to investigate the role of microRNA-128-3p in regulating hydrochloric acid (HCl)-induced cell injury in human esophageal squamous Het-1A cells. Het-1A cells were treated with HCl (pH 4.0) to induce esophageal injury like this caused by reflux. Read More

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http://dx.doi.org/10.1691/ph.2018.8554DOI Listing
September 2018

Cardamonin protects against adverse cardiac remodeling through mTORC1 inhibition in mice with myocardial infarction.

Pharmazie 2018 09;73(9):508-512

The mTORC1-dependent signaling pathway is mainly involved in the adverse left ventricular remodeling (ALVR) process after myocardial infarction (MI). However, whether mTORC1 inhibition by cardamonin attenuates ALVR after MI is still not reported. Twenty mice were randomly assigned into three groups: sham group (10 ml/kg/day PBS, n=6), model group (MI and 10 ml/kg/day PBS, n=7) and cardamonin-treated group (MI and 20 mg/kg/day cardamonin, n=7). Read More

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http://dx.doi.org/10.1691/ph.2018.8600DOI Listing
September 2018

Effects of the antiretroviral drug 2'-deoxy-2'-β-fluoro-4'-azidocytidine (FNC) on P-gp, MRP2 and BCRP expressions and functions.

Pharmazie 2018 09;73(9):503-507

The purpose of the present study was to dig into recent studies designed to characterize the impacts of 2'-deoxy-2'-β-fluoro-4'-azidocytidine (FNC) on P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2) and breast cancer resistance protein (BCRP). Specifically, the modulation effects of FNC on P-gp, MRP2 and BCRP protein expressions were assessed by western blot methods. 5 (and 6)-Carboxy-2',7'-dichloroflourescein (CDF) and BODIPY-prazosin were used to provide indications of alterations of MRP2 and BCRP activities. Read More

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http://dx.doi.org/10.1691/ph.2018.8555DOI Listing
September 2018
2 Reads

Development of a novel celecoxib-loaded nanosuspension using a wet media milling process.

Pharmazie 2018 09;73(9):498-502

To develop a novel celecoxib (CXB)-loaded drug delivery system, numerous nanosuspensions were prepared with various polymers and surfactants using a wet media milling process, and their particle sizes were subsequently determined. A 24 full factorial design was used to identify the most appropriate preparation conditions. Pharmacokinetics of the selected nanosuspension were performed in rats and compared with those of a drug powder and a commercial CXB-loaded product. Read More

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http://dx.doi.org/10.1691/ph.2018.8035DOI Listing
September 2018
1 Read

Synthesis and characterization of four process impurities in pazopanib.

Pharmazie 2018 09;73(9):494-497

Pazopanib (trade name Votrient®) is a potent and selective multi-targeted tyrosine kinase inhibitor that blocks tumor growth and inhibits angiogenesis. Based on a recently reported procedure, we herein report the first synthesis of four potential process impurities generated in the production of pazopanib. The structure of these impurities were synthesized and characterized by 1H NMR, 13C NMR and HRMS data. Read More

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http://dx.doi.org/10.1691/ph.2018.8538DOI Listing
September 2018
1 Read

JQ1: a novel potential therapeutic target.

Pharmazie 2018 09;73(9):491-493

The bromo- and extra-terminal domain (BET) signaling pathway plays an important role in cell proliferation, immune responses, and pro-inflammatory events. JQ1 as a first-in-class potent and selective inhibitor of the BRD4 signaling pathway is widely used for tumor biology studies. It was found that JQ1 could potently reduce cancer cell viability in vitro and in vivo. Read More

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http://dx.doi.org/10.1691/ph.2018.8480DOI Listing
September 2018
1 Read

Efficacy of pegfilgrastim administration in patients with esophageal cancer treated with docetaxel, cisplatin, and 5-fluorouracil.

Pharmazie 2018 Oct;73(10):613-616

Chemotherapy is among the standard treatments for esophageal cancer. The docetaxel, 5-fluorouracil, and cisplatin (DCF) protocol yields a better response rate than 5-fluorouracil plus cisplatin. However, the incidence of side effects, such as febrile neutropenia and hematologic toxicity, is also significantly high with the DCF protocol. Read More

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http://dx.doi.org/10.1691/ph.2018.8576DOI Listing
October 2018
1 Read

Relationship between medication adherence and glycemic control in Japanese patients with type 2 diabetes.

Pharmazie 2018 Oct;73(10):609-612

A cross-sectional survey of 358 patients was conducted among type 2 diabetes patients recruited at medical institutions or via an online research company. Medication adherence was measured using the 8-item Morisky Medication Adherence Scale (MMAS-8). Univariate and multivariate regression analyses of glycosylated hemoglobin (HbA1c) were performed in addition to assessing demographic and disease characteristics and MMAS-8. Read More

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http://dx.doi.org/10.1691/ph.2018.8587DOI Listing
October 2018

Incompatibilities in paediatric intensive care - pitfalls in drug information.

Pharmazie 2018 Oct;73(10):605-608

Drug incompatibilities can lead to loss of effectiveness of drugs or to increased risk for undesirable effects that can even be life-threatening. Especially children are at high risk. Databases are an important source of information in routine care to avoid incompatibilities. Read More

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http://dx.doi.org/10.1691/ph.2018.8585DOI Listing
October 2018

Factors influencing the use of over-the-counter drugs and health foods/supplements.

Pharmazie 2018 Oct;73(10):598-604

Over-the-counter (OTC) drugs and health foods/supplements are used as means of self-medication with the aim of preventing diseases and maintaining health. No reports have yet addressed the relationship between healthcare systems and self-medication. Here, we carried out a retrospective survey to identify healthcare system factors affecting OTC drug and health food/supplement usage. Read More

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http://dx.doi.org/10.1691/ph.2018.8617DOI Listing
October 2018

Andrographolide inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cell line C666-1 through LKB1-AMPK-dependent signaling pathways.

Pharmazie 2018 Oct;73(10):594-597

Background: Andrographolide (Andro) belongs to the main bioactive ingredients of Andrographis paniculata. Many studies have shown that andro has a variety of pharmacological activities such as anti-inflammatory, anti-bacterial, anti-virus, anti-oxidant, immune regulation and liver protective effects. Moreover andro has been reported to have anticancer activity in multiple types of cancer, including gastric cancer, breast cancer, lung cancer and so on. Read More

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http://dx.doi.org/10.1691/ph.2018/8583DOI Listing
October 2018
9 Reads
1.003 Impact Factor

Immunomodulatory and anti-inflammatory effects of total flavonoids of by regulating NF-ΚB and MAPK signalling pathways in RAW 264.7 macrophages.

Pharmazie 2018 Oct;73(10):589-593

Astragalus membranaceus Bunge has long been used to improve immune function in traditional Chinese medicine. The total flavonoids of Astragalus (TFA) are the main active components isolated from Astragalus membranaceus Bunge. Our recent study has shown that TFA has in vivo and in vitro immunomodulatory and anti-inflammatory effects; however, its potential mechanisms have not yet been elucidated. Read More

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http://dx.doi.org/10.1691/ph.2018.8633DOI Listing
October 2018
11 Reads

Telmisartan regulates the development of cerebral ischemia by alleviating endoplasmic reticulum stress.

Pharmazie 2018 Oct;73(10):585-588

Recent studies have shown that telmisartan (TMS) is effective for the protection against ischemia/brain damage in rat models. However, the specific underlying mechanism is poorly understood. In line with previous results, our data showed that TMS improves CBF and physiological variables, including pH, pCO2, pO2. Read More

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http://dx.doi.org/10.1691/ph.2018.8592DOI Listing
October 2018

An effective quantitative fingerprint method for evaluating the quality consistency of .

Pharmazie 2018 Oct;73(10):579-584

An HPLC method for combined quantification of five major constituents (vicenin-1, schaftoside, isoschaftoside, vicenin-3 and isovitexin) of Desmodium styracifolium was developed to evaluate the quality consistency of this medicinal herb. The chromatographic separation was accomplished on an Agilent 5 TC-C18 column (4.6 × 250 mm, 5 μm) with gradient elution using acetonitrile and 0. Read More

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http://dx.doi.org/10.1691/ph.2018.8590DOI Listing
October 2018

The use of experimental design for the development and validation of an HPLC-ECD method for the quantitation of efavirenz.

Pharmazie 2018 Oct;73(10):570-578

A high performance liquid chromatography with electrochemical detection (HPLC-ECD) method for the quantitation of efavirenz (EFV) was developed, since traditional HPLC-UV methods may be inappropriate, given that EFV undergoes photolytic degradation following exposure to UV light. This work describes the use of response surface methodology (RSM) based on a central composite design (CCD) to develop a stability-indicating HPLC method with pulsed ECD in direct current (DC) mode at an applied potential difference and current of +1400 mV and 1.0 μA for the analysis of EFV. Read More

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http://dx.doi.org/10.1691/ph.2018.8074DOI Listing
October 2018
2 Reads

HPLC electrochemical detection and quantification of monoamines and their metabolites in rat brain tissue samples.

Pharmazie 2018 Oct;73(10):563-569

The monitoring of monoamines and their metabolites in CNS samples can be very valuable in pharmaceutical and biomedical research. A specific high performance liquid chromatography, coupled to a coulometric electrochemical detection method, for the assay of monoamines (dopamine, norepinephrine, epinephrine and serotonin) and their metabolites in rat brain tissue samples was developed. The chromatographic separation was achieved on a C8 reversed phase column with a mobile phase consisting of 0. Read More

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http://dx.doi.org/10.1691/ph.2018.8099DOI Listing
October 2018

Isolation and characterization of the acid and base degradation products of andrographolide.

Pharmazie 2018 Oct;73(10):559-562

Andrographolide was subjected to degradation under acidic and basic conditions. Three degradation products including two novel compounds, 8,9-didehydroandrographolide (AG-A) and 15-seco-andrographolide (AG-B2), and a known product, 14-deoxy-11,12-didehydroandrographolide (AG-B1), were isolated by chromatography and identified on the basis of their NMR and MS data. The degradation product, AG-A, may result from the isomerization of andrographolide under acidic conditions whereas the base degradation products, AG-B1 and AG-B2, were formed most likely due to the dehydration of allyl alcohol and the hydrolysis of andrographolide at the lactone ring, respectively. Read More

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http://dx.doi.org/10.1691/ph.2018.8082DOI Listing
October 2018

A convenient identification of carbamate-derived drug substances.

Authors:
B Lohrer F Bracher

Pharmazie 2018 Oct;73(10):555-558

The "second identification" of drugs in pharmacies and hospital pharmacies affords the availability of easy to perform and robust tests. Besides determination of melting points and simple chromatography (TLC), reliable color and precipitation reactions are common techniques for this purpose. Preferentially, these reactions allow for the identification of typical functional groups in the drugs. Read More

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http://dx.doi.org/10.1691/ph.2018.8092DOI Listing
October 2018

Contribution of pharmacists with expertise in infectious diseases to appropriate individualized vancomycin dosing.

Pharmazie 2018 07;73(7):422-424

Background/aim: Dose adjustment of vancomycin (VCM) is important in improving clinical outcomes and avoiding adverse effects such as nephrotoxicity. Although pharmacist-managed VCM therapy has been reported to optimize treatment, there are no studies focused on pharmacist expertise to date. In this study, we compared the contribution of pharmacists trained for infectious diseases and general pharmacists to dose adjustment of VCM. Read More

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http://dx.doi.org/10.1691/ph.2018.8427DOI Listing