12,164 results match your criteria Die Pharmazie[Journal]


Association between polymorphism and hypospadias: a meta-analysis.

Pharmazie 2019 Feb;74(2):125-128

Steroid 5a-reductase type-2 () has been reported to be associated with hypospadias, but the available results are not consistent across studies. Therefore, we conducted a comprehensive meta-analysis to systematically review the association between gene polymorphisms and hypospadias. Public databases PubMed and Embase were searched before March 1, 2016. Read More

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http://dx.doi.org/10.1691/ph.2019.8768DOI Listing
February 2019
1.003 Impact Factor

Risk factors for decreased teicoplanin trough concentrations during initial dosing in critically ill patients.

Pharmazie 2019 Feb;74(2):120-124

Here, we investigated the risk factors for decreased teicoplanin plasma trough concentrations relative to the initial dosing in critically ill patients. Data obtained from 80 eligible critically ill patients who received intravenous teicoplanin were retrospectively analyzed. Risk factors for decreases in teicoplanin trough concentrations 72 h after administration of teicoplanin of more than 30% relative to predicted concentrations based on initial dosing setting were identified by logistic regression analysis. Read More

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http://dx.doi.org/10.1619/ph.2019.8731DOI Listing
February 2019

Cyclic adenosine phosphate improves functional recovery after spinal cord injury via activating unfolded protein response.

Pharmazie 2019 Feb;74(2):115-119

The current study aimed to evaluate the role and underlying mechanism of cyclic adenosine phosphate (cAMP) on the functional recovery of spinal cord injury (SCI). Basso, Beattie and Bresnahan (BBB) scoring and inclined plane test indicated that cAMP treatment improved the functional recovery of SCI rats. Real time PCR and western blot analysis showed the mRNA and protein levels of IRE1, PERK, and ATF6 were increased in the SCI rats than those of sham control. Read More

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http://dx.doi.org/10.1691/ph.2019.8347DOI Listing
February 2019

MiR-761 inhibits colorectal cancer cell proliferation and invasion through targeting HDAC1.

Pharmazie 2019 Feb;74(2):111-114

Colorectal cancer (CRC) is one of the most common cancer diagnoses. Histone deacetylase (HDAC) overactivity in CRC could promote cancer progression. HDAC1, a member of the HDAC family, is found aberrantly expressed in CRC, but it remains unclear whether the expression of HDAC1 can be regulated by microRNA. Read More

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http://dx.doi.org/10.1691/ph.2019.8756DOI Listing
February 2019

The involvement of blood cells in the phosphorylation of the selective sphingosine-1-phosphate receptor 1 agonist SYL-927.

Pharmazie 2019 Feb;74(2):107-110

SYL-927 is a selective sphingosine-1-phosphate receptor 1 (S1P) agonist for autoimmune diseases. It undergoes phosphorylation to the active SYL-927-P , which activates S1P on lymphocytes, causing lymphopenia by retention of lymphocytes in the lymph nodes. The aim of this study was to identify the involvement of blood cells in the phosphorylation of SYL-927. Read More

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http://dx.doi.org/10.1691/ph.2019.8809DOI Listing
February 2019

Paeonol ameliorates lipopolysaccharides-induced acute lung injury by regulating TLR4/MyD88/ NF-κB signaling pathway.

Pharmazie 2019 Feb;74(2):101-106

Paeonol has been found to hold analgesic, antipyretic and anti-allergic activities. Here, we investigated the protective effect of paeonol on acute lung injury (ALI) induced by lipopolysaccharides (LPS) and explored the underlying mechanisms on TLR4/MyD88/NF-κB signaling pathway. C57BL/6 mice were randomly divided into control (normal saline, NS, 0. Read More

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http://dx.doi.org/10.1691/ph.2019.8860DOI Listing
February 2019

Bioavailability of moclobemide from two formulation tablets in healthy humans.

Pharmazie 2019 Feb;74(2):97-100

A ,,sine qua non" requirement for a generic formulation to be admitted for a medical use is to provide bioavailability studies in healthy subjects. Therefore, those studies were performed for 150 mg moclobemide tablets (Jelfa, Poland) versus 150 mg Aurorix (Hoffmann la Roche) reference tablets. An open-label, two-phase crossover study was conducted with 10 healthy subjects. Read More

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http://dx.doi.org/10.1691/ph.2019.8819DOI Listing
February 2019

Development, manufacture and characterization of niosomes for the delivery for nevirapine.

Pharmazie 2019 Feb;74(2):91-96

Nevirapine (NVP), used for the treatment of HIV/AIDS, exhibits unpredictable oral bioavailability, has a poor side effect profile and requires frequent dosing. Niosomes are novel drug delivery systems that have the potential to overcome these challenges. A thin layer hydration approach was used to produce niosomes and optimisation was undertaken using design of experiments (DoE) and response surface methodology (RSM) establish and identify parameters that may affect the manufacture of niosomes. Read More

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http://dx.doi.org/10.1691/ph.2019.8168DOI Listing
February 2019

Hyaluronic acid-coated single-walled carbon nanotubes loaded with doxorubicin for the treatment of breast cancer.

Pharmazie 2019 Feb;74(2):83-90

Hyaluronic acid (HA)-modified amino single-walled carbon nanotubes (NH₂-SWCNTs) were developed for targeted delivery of doxorubicin (DOX) to improve breast cancer treatment. HA, which specifically binds to the CD44 receptor, was non-covalently coated on NH₂-SWCNTs through simply electrostatic adsorption. The formed SWCNTs-DOX-HA complexes were characterized in terms of morphology, particle size and zeta potential by different techniques. Read More

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http://dx.doi.org/10.1691/ph.2019.8152DOI Listing
February 2019

Simplified LC-MS/MS method for quantification of IG-105, a novel tubulin ligand, and its application to the pharmacokinetic study in rats at the anticancer effective dose.

Pharmazie 2019 Feb;74(2):79-82

IG-105, N-(2, 6-dimethoxypyridine-3-yl)-9-methylcarbazole-3-sulfonamide, a novel carbazole sulfonamide, shows a potent anticancer activity in a variety of human tumor cells and . In the present study, a rapid and convenient liquid chromatography/tandem mass spectrometry (LC-MS/MS) method was developed and applied to the pharmacokinetic study of IG-105 in rats. Chromatographic separation was accomplished on a C column using an isocratic mobile phase of acetonitrile-water-acetic acid (56:44:0. Read More

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http://dx.doi.org/10.1691/ph.2019.8157DOI Listing
February 2019

Synthesis and antibacterial activity of novel icariin derivatives.

Authors:
A Wang Y Xu

Pharmazie 2019 Feb;74(2):73-78

A series of aromatic sulfonyls substituted icariin derivatives was synthesized and their antibacterial activities against (including drug-sensitive bacteria and drug-resistant bacteria) were evaluated. Among them, compound exhibited high potency against methicillin-sensitive (MSSA) and resistant strains of (MRSA) with MIC values of 1-2 mmol/L. Reverse virtual screening and molecule docking analysis indicated that compound might bind the allosteric site of PBP2a that may inhibit cell wall synthesis, with the advantage of activity against multidrug resistant SPR experiment further confirmed the binding affinity. Read More

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http://dx.doi.org/10.1691/ph.2019.8866DOI Listing
February 2019
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Biological activity and health promoting effects of psoralidin.

Pharmazie 2019 Feb;74(2):67-72

Psoralidin, a prenylated coumestrol isolated from the seed of a traditional Chinese medicine L., has been demonstrated to exhibit anti-inflammatory, anti-cancer, anti-oxidative, estrogenic, neuroprotective, anti-bacterial, and anti-parasite activities. Due to prenylation, psoralidin exhibits stronger estrogenic activity with no obvious adverse effects and shows a close association with management of osteoporosis and some cancers. Read More

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http://dx.doi.org/10.1691/ph.2019.8619DOI Listing
February 2019

A case of under-dosing after raltegravir formulation change in an elderly patient treated for HIV.

Pharmazie 2019 Jan;74(1):62-63

Our case was a 70-year-old male (height: 168 cm, weight: 74.3 kg) with polypharmacy (total 15 drugs including 10 tablets) who was treated for HIV infection. His dosing schedule of raltegravir was changed from BID (a 400 mg tablet, twice) to QD (2x600 mg tablet, once). Read More

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http://dx.doi.org/10.1691/ph.2019.8788DOI Listing
January 2019

Cyanidin-3--glucoside chloride acts synergistically with luteolin to inhibit the growth of colon and breast carcinoma cells.

Pharmazie 2019 Jan;74(1):54-61

In this study, we investigated whether the combination of cyanidin-3--glucoside chloride and luteolin could inhibit the growth of HCT-8 colon and MCF-7 breast carcinoma cells, and whether the effect of the combination was greater than the effect of either drug on its own. Growth inhibition was assessed using the CCK-8 assay, level of apoptosis and cell cycle distribution were determined using flow cytometry, and the mechanism of apoptosis induction was explored using a colorimetric assay of caspases-3 and -9. Experiments indicated that combination treatment inhibited proliferation and increased apoptosis in both cell lines to a greater extent than either drug on its own. Read More

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http://dx.doi.org/10.1691/ph.2019.8746DOI Listing
January 2019

Improved gastrointestinal stability of solid lipid nanoparticles using comb-shaped amphiphilic inulin derivatives.

Pharmazie 2019 Jan;74(1):47-53

In order to reduce enzymatic degradation and thereby enhance the stability of solid lipid nanoparticles (SLNs) in the gastrointestinal tract, comb-shaped amphiphilic macromolecular material (CAM) of dodecyl inulin (Inu12) and octadecyl inulin (Inu18) were designed as the emulsifier and stabilizer to modify SLNs (Inu12/Inu18-SLNs). Inu12-SLNs and Inu18-SLNs had similar particle size as the control SLNs (P188-SLNs and Tween-SLNs) prepared with the straight chain surfactants, poloxamer 188 and tween-80 as the emulsifier, which ranged from 220 nm to 270 nm. The zeta potentials of all the SLNs formulations were slightly negative. Read More

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http://dx.doi.org/10.1691/ph.2019.8140DOI Listing
January 2019

Intranasal administration of pullulan-based nanoparticles for enhanced delivery of adriamycin into the brain: and evaluation.

Pharmazie 2019 Jan;74(1):39-46

Intranasal (i.n.) administration is an efficient route for enhancing drug delivery to the brain, bypassing the blood-brain barrier (BBB) and eliminating systemic side effects. Read More

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http://dx.doi.org/10.1691/ph.2019.8124DOI Listing
January 2019

Nystatin antifungal micellar systems on endotracheal tubes: development, characterization and evaluation.

Pharmazie 2019 Jan;74(1):34-38

Decontamination of patients' clinical devices in intensive care units is generally performed with an antifungal suspension. Nystatin is a widely-used high spectrum antifungal due to its low systemic absorption. However, nystatin has high hydrophobicity which hinders the contact with the internal lumen of the devices. Read More

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http://dx.doi.org/10.1691/ph.2019.8138DOI Listing
January 2019

Species-specificity in the interaction of IgE with FcεRI between humans and rats.

Pharmazie 2019 Jan;74(1):29-33

The interaction of immunoglobulin E (IgE) to its high-affinity receptor (FcεRI) plays a key role in triggering allergic reactions. However, it is still controversial whether species specificity influences the binding ability between humans and rodents. Recombinant hFcεRIα / RBL-2H3 and hFcεRIα / MGC-803 cells were prepared and sensitized with hIgE/anti-hIgE antibody or DNP-IgE/DNP-BSA, respectively. Read More

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http://dx.doi.org/10.1691/ph.2019.8771DOI Listing
January 2019
1 Read

Long noncoding RNA SNHG6 contributes to ventricular septal defect formation via negative regulation of miR-101 and activation of Wnt/β-catenin pathway.

Pharmazie 2019 Jan;74(1):23-28

This study aimed to investigate the role and regulatory mechanism of small nucleolar RNA host gene 6 (SNHG6), a long noncoding RNA, in the formation of ventricular septal defect (VSD). The expression of SNHG6 in fetal cardiac tissues with VSD, mouse heart embryo development and the differentiation of P19 cells into cardiomyocytes were determined. Moreover, the effect of aberrant expression of SNHG6 on P19 cell proliferation, cell cycle, apoptosis and differentiation was further analyzed to explore the role of SNHG6 in affecting myocardial development. Read More

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http://dx.doi.org/10.1691/ph.2019.8736DOI Listing
January 2019

Differential pulse polarographic investigation of micafungin and anidulafungin using a dropping mercury electrode.

Pharmazie 2019 Jan;74(1):18-22

The electrochemical behavior of the echinocandin antifungals anidulafungin (AF) and micafungin (MF) has been investigated by differential pulse polarography (DPP). The measurements were carried out in a supporting electrolyte solution consisting of Britton-Robinson buffer and methanol at various substance concentrations and pH values. An amperometric cell with a three electrode system consisting of a dropping mercury electrode (DME) as working electrode, an auxiliary platinum electrode and an Ag/AgCl reference electrode was used in all experiments. Read More

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http://dx.doi.org/10.1691/ph.2019.8680DOI Listing
January 2019

Synthesis of phenylpyrimidinones as guanylyl cyclase C inhibitors.

Pharmazie 2019 Jan;74(1):15-17

Diarrhea is one of the most important causes of mortality in the developing world, being responsible for 2.5 million deaths each year. Many of these deaths are caused by enterotoxigenic strains of bacteria, like that produce enterotoxins that cause acute watery diarrhea, commonly defined as secretory diarrhea. Read More

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http://dx.doi.org/10.1691/ph.2019.8775DOI Listing
January 2019

Efficacy and safety of different doses of alirocumab in reducing low-density lipoprotein cholesterol levels: a network meta-analysis.

Pharmazie 2019 Jan;74(1):8-14

This study aimed to conduct a network meta-analysis of the efficacy and safety of different doses of alirocumab in reducing low-density lipoprotein cholesterol levels. In the present study, a total of 16 studies were selected, published between January 2012 and October 2016. Pair-wise and network meta-analyses was used to carry out a direct and indirect comparison of the three treatment strategies of alirocumab in patients with hypercholesterolemia. Read More

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http://dx.doi.org/10.1691/ph.2019.8584DOI Listing
January 2019

Targeting HIF-1α signaling pathway for gastric cancer treatment.

Pharmazie 2019 Jan;74(1):3-7

Gastric cancer is a common malignancy with high mortality and limited therapeutic options. Hypoxia inducible factor-1 α (HIF-1α) is the key responser adapted to tumor hypoxia. Under hypoxia conditions, HIF-1α signaling is activated and responsible for cell biology associated with metabolism, inflammation, vascular homeostasis and tumorigenesis. Read More

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http://dx.doi.org/10.1691/ph.2019.8674DOI Listing
January 2019

Relationship between the administration of nicardipine hydrochloride and the development of delirium in patients on mechanical ventilation.

Pharmazie 2018 12;73(12):740-743

A history of hypertension is a known risk factor for delirium in patients in intensive care units, but the effect of antihypertensive agents on delirium development is unclear. Nicardipine, a calcium channel blocker, is widely used in ICU as a treatment agent for hypertensive emergency. This study investigated the relationship between the administration of nicardipine hydrochloride and delirium development in patients under mechanical ventilation. Read More

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http://dx.doi.org/10.1691/ph.2018.8711DOI Listing
December 2018
2 Reads

Applicability of hemodialysis clearance parameter for vancomycin therapeutic drug monitoring during continuous hemodiafiltration in an infant.

Pharmazie 2018 12;73(12):737-739

Cases requiring vancomycin administration planning in infants undergoing continuous hemodiafiltration (CHDF) are extremely rare. Here, we report a single case in which vancomycin therapeutic drug monitoring and administration planning were implemented for an infant requiring CHDF. The patient was diagnosed with wound infection after gastrostomy and enterotomy surgery and received vancomycin treatment for infection with methicillin-resistant . Read More

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http://dx.doi.org/10.1691/ph.2018.8748DOI Listing
December 2018
1 Read

Antiviral activity of propolis special extract GH 2002 against virus .

Pharmazie 2018 12;73(12):733-736

Propolis is a generic name for a biological substance produced by bees used for multiple purposes in folk medicine. Propolis special extract GH 2002 is crude propolis highly purified by a special procedure and freed from the accompanying substances like pollen, wax, resins. The cytotoxic and antiherpetic effect of propolis extracts against virus (VZV) was analysed in cell culture, and revealed a moderate cytotoxicity on lung fibroblasts with a CC of 380 μg/ml. Read More

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http://dx.doi.org/10.1691/ph.2018.8672DOI Listing
December 2018
2 Reads

Retinoic acid increases the anticancer effect of paclitaxel by inducing differentiation of cancer stem cells in melanoma.

Authors:
Y B Wang B Sun B Han

Pharmazie 2018 12;73(12):729-732

Malignant melanoma is a highly lethal disease, and advanced stages of melanoma have proven to be resistant to many chemotherapeutic drugs including temozolomide and paclitaxel. Cancer stem cells (CSCs) have been identified and isolated in different cancers including melanoma, and have been proven playing important role in the drug resistance. Retinoic acid (RA) is a promising anticancer agent, which can induce differentiation of CSCs. Read More

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http://dx.doi.org/10.1691/ph.2018.8715DOI Listing
December 2018
1 Read

High glucose induces the apoptosis of HUVECs in mitochondria dependent manner by enhancing VDAC1 expression.

Pharmazie 2018 12;73(12):725-728

Mellithemia are diabetic patients' emblematic syndrome, which would induce vasculopathy resulting from apoptosis of vascular endothelial cells. The pathological mechanism of high glucose-induced apoptosis of vascular endothelial cells is investigated in the present study utilizing HUVEC cells. As high glucose-induced apoptosis is caused by elevated mitochondrial permeability-mediated release of mitochondrial cytochrome c, voltage-dependent anion channel (VDAC1), the controller of mitochondrial permeability, and its regulator Bax were investigated. Read More

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http://dx.doi.org/10.1691/ph.2018.8544DOI Listing
December 2018
3 Reads

Walnut oil promotes healing of wounds and skin defects in rats regulating the NF-kB pathway.

Pharmazie 2018 12;73(12):721-724

The effects of walnut oil on wound healing and skin injury repair was observed in Sprague-Dawley (SD) rats, and mechanism of action was investigated. Normal SD rats were divided into an experimental group and a control group. Each group was observed at4 time points (day [D]3, D7, D14, and D21). Read More

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http://dx.doi.org/10.1691/ph.2018.8605DOI Listing
December 2018
1 Read

A cell-internalizing peptide endows tumstatin7 with enhanced antitumor properties.

Pharmazie 2018 12;73(12):715-720

Tumstatin7 (CNYYSNS) is an antitumor peptide derived from the NC1 domain of Type IV collagen that has been associated with tumor angiogenesis. In this work, we generated a peptide composed of tumstatin7 fused to TAT, a cell-internalizing peptide consisting of 11 amino acids. Tumstatin7-TAT was internalized by cells and triggered cell death. Read More

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http://dx.doi.org/10.1691/ph.2018.8623DOI Listing
December 2018
1 Read
1.003 Impact Factor

Loss of miR-217 promotes osteosarcoma cell proliferation through targeting SETD8.

Pharmazie 2018 12;73(12):711-714

Recently, many kinds of microRNAs (miRNAs) have been found to play a critical role in progression of osteosarcoma (OS). miR-217 was reported to function as a tumor suppressor in a number of human cancers but its precise mechanism to exert the suppressive role remains to be investigated. In this study, we found that miR-217 was downregulated in OS tissues and its downregulation predicts poor overall survival of OS patients. Read More

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http://dx.doi.org/10.1691/ph.2018.8644DOI Listing
December 2018
1 Read

The anti-apoptotic effect of nerve growth factor on propofol-induced neurotoxicity in hippocampal neurons is Rac1 dependent.

Pharmazie 2018 12;73(12):706-710

Propofol has been considered as a near-ideal anesthetic agent since its introduction 40 years ago. However, the side effects of propofol including bacterial contamination, hyperlipidemia, and neurotoxicity also aroused attention. Nerve growth factor (NGF) plays a pivotal role in the development, differentiation, and survival of the neurons of the peripheral and central nervous system. Read More

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http://dx.doi.org/10.1691/ph.2018.8726DOI Listing
December 2018
2 Reads

Functional expression of breast cancer resistance protein and cholesterol effect in human erythrocyte membranes.

Pharmazie 2018 12;73(12):700-705

In human erythrocyte membranes, various influx and efflux transporters are functionally expressed. However, their transport characteristics and modulation under disease states are not fully understood. In this study, we first examined the expression and detailed transport characteristics of breast cancer resistance protein (BCRP), an efflux ABC transporter, using inside-out membrane vesicles (IOVs) prepared from human erythrocytes, and then studied the effect of membrane cholesterol on BCRP function. Read More

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http://dx.doi.org/10.1691/ph.2018.8724DOI Listing
December 2018
3 Reads

GLP-1 attenuates Ang II-induced proliferation and migration in rat aorta smooth muscle cells inhibition of the RhoA/ROCK2 signaling pathway.

Pharmazie 2018 12;73(12):692-699

Glucagon-like peptide 1 (GLP-1), a neuroendocrine hormone produced by the gastrointestinal tract, plays a significant role in blood glucose regulation; drugs derived from GLP-1 are currently used for the treatment of type 2 diabetes. In addition to regulating glucose homeostasis, the protective effects of GLP-1 on the cardiovascular system are also of interest. However, the vascular protective mechanisms of GLP-1 remain unclear. Read More

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http://dx.doi.org/10.1691/ph.2018.8693DOI Listing
December 2018
2 Reads

Bioavailability of propylthiouracil from two formulation tablets.

Pharmazie 2018 12;73(12):688-691

Bioavailability studies were performed for 50 mg propylthiouracil tablets (Jelfa, Poland) 50 mg propycil tablets (Solvay, Germany). An open-label, two-phase, crossover study was conducted with 15 healthy subjects. All subjects were randomly assigned a drug assignment number from I to XV, which was used throughout the experimental period. Read More

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http://dx.doi.org/10.1691/ph.2018.8552DOI Listing
December 2018
5 Reads

Quality control of hospital preparations: Establishment of a simple and rapid method for quantifying ulinastatin in vaginal suppositories.

Pharmazie 2018 12;73(12):683-687

Ulinastatin vaginal suppositories, used to prevent threatened premature delivery, are frequently used in hospitals. However, there is no established method for quantifying ulinastatin contained in suppositories. Therefore, we investigated a simple and efficient method for quantifying ulinastatin contained in suppositories. Read More

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http://dx.doi.org/10.1691/ph.2018.8069DOI Listing
December 2018
2 Reads

Cleopatra: from turpentine and juniper to ionone and irone.

Pharmazie 2018 11;73(11):676-680

Cleopatra VII (69-30 BC), the last Ptolemaic ruler of Egypt, is probably best known for her love affairs with Julius Caesar (100-44 BC) and Marcus Antonius (83-30 BC). Rightly or wrongly she became the epitome of shrewd seduction, leading brave Roman commanders on a path to debauchery and destruction. Among the seductive strategies attributed to her is the ingestion of small amounts of turpentine [the resin of the terebinth tree ()] or of derived oil () with the purpose of conferring to her urine a more pleasant scent reminding of violets. Read More

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http://dx.doi.org/10.1691/ph.2018.8142DOI Listing
November 2018
14 Reads

Risk factors increasing blood pressure in Japanese colorectal cancer patients treated with bevacizumab.

Pharmazie 2018 11;73(11):671-675

Bevacizumab has been reported to increase blood pressure. However, the factors, including patient characteristics and laboratory data contributing to this side effect remain unclear. Therefore, we investigated the relationships between increased blood pressure and bevacizumab administration, patient characteristics, and laboratory data. Read More

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http://dx.doi.org/10.1691/ph.2018.8664DOI Listing
November 2018
8 Reads

Protective effects and possible molecular mechanism of Thunb. extract on acetaminophen-induced hepatotoxicity.

Pharmazie 2018 11;73(11):666-670

Thunb. is a traditional hepatoprotective Chinese medicine, and in research, much effort has been focused on the protection against alcoholic liver injury. In this study, the protective effects of a fruit ethanol extract of (FE) against APAP-induced acute hepatotoxicity in mice and the possibly involved molecular mechanisms were investigated. Read More

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http://dx.doi.org/10.1691/ph.2018.8650DOI Listing
November 2018
8 Reads

High expression of TAZ/YAP promotes the progression of malignant melanoma and affects the postoperative survival of patients.

Pharmazie 2018 11;73(11):662-665

YAP/TAZ have been reported to be highly expressed in malignant tumors. This research was aimed to study the expression of TAZ/YAP protein in malignant melanoma and to investigate its relationship to the clinicopathology and prognosis of patients with malignant melanoma. A total of 156 pairs of malignant melanoma tumor tissues and melanocytic nevi tissues were collected. Read More

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http://dx.doi.org/10.1691/ph.2018.8499DOI Listing
November 2018
7 Reads

Analgesic effects of the novel α₂δ ligand mirogabalin in a rat model of spinal cord injury.

Pharmazie 2018 11;73(11):659-661

Mirogabalin, which is a novel ligand for the α₂δ subunit of voltage-gated calcium channels, is under development for the treatment of pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Mirogabalin possesses unique binding characteristics to α₂δ subunits and potent and long-lasting analgesic effects in peripheral neuropathic pain models. In the present study, we investigated the analgesic effects of mirogabalin in a rat model of spinal cord injury as an experimental animal model for central neuropathic pain. Read More

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http://dx.doi.org/10.1691/ph.2018.8550DOI Listing
November 2018
15 Reads

Pterostilbene's protective effects against photodamage caused by UVA/UVB irradiation.

Pharmazie 2018 11;73(11):651-658

The aim of this study was to further elucidate the mechanism of pterostilbene against UVA/UVB irradiation and the Nuclear factor E2-related factor 2 (Nrf2) signal pathway. A photo-damage model with UVA/UVB irradiation in HaCat cells was established and used in this study. The dose of pterostilbene was selected through MTS assay. Read More

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http://dx.doi.org/10.1691/ph.2018.8598DOI Listing
November 2018
2 Reads

Effects of dexmedetomidine, propofol and etomidate on the intraoperative wake-up in the cerebral functional area under the guidance of entropy index.

Pharmazie 2018 11;73(11):647-650

The study observed the efficacy and safety of dexmedetomidine, propofol and etomidate on brain functional areas in patients undergoing wake-up brain surgery under the guidance of entropy index. Sixty patients undergoing wake-up brain surgery on brain functional areas were enrolled, and randomly divided into three groups: dexmedetomidine group (group D), propofol group (group P) and etomidate group (group E), 20 in each. The vital signs, entropy indices of each time point, wake-up time, wake-up quality and adverse reaction in the wake-up period were observed and compared. Read More

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http://dx.doi.org/10.1691/ph.2018.8613DOI Listing
November 2018
4 Reads

Levetiracetam inhibits endocytosis and augments short-term depression.

Authors:

Pharmazie 2018 11;73(11):643-646

Levetiracetam (LEV) is an anti-epileptic drug with demonstrated efficacy against generalized seizures. Recent studies have found that LEV affects the release of neurotransmitters by binding to synaptic vesicle protein 2A (SV2A). However, the details of LEV regulation of synaptic transmission remain poorly understood. Read More

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http://dx.doi.org/10.1691/ph.2018.8634DOI Listing
November 2018
2 Reads

Drug likeness, targets, molecular docking and ADMET studies for some indolizine derivatives.

Authors:
A Belal

Pharmazie 2018 11;73(11):635-642

The aim of this work was to investigate the biomolecular targets for a library of indolizines, study their molecular properties, drug likeness, target prediction, performing docking studies and exploring their ADMET profile in search for a lead compound. All compounds appeared to comply with Lipinski's rule without any violation, additionally their solubility is viewed good except for compounds which are anticipated to be reasonably soluble, their Milog P score was 4.18-4. Read More

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http://dx.doi.org/10.1691/ph.2018.8061DOI Listing
November 2018
1 Read

An UPLC-MS/MS method for the determination of EAI045 in plasma and tissues and its application to pharmacokinetic and distribution studies in rats.

Pharmazie 2018 11;73(11):630-634

EAI045 represents a fourth generation allosteric EGFR TKI compound which targets and EGFR mutants. The study reported herein describes a method to explore the distribution of EAI045 in rat tissues as well as to quantify it in plasma. The method used here is an ultra-performance liquid chromatography-tandem mass spectrometry with high sensitivity and selectivity. Read More

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http://dx.doi.org/10.1691/ph.2018.8123DOI Listing
November 2018
15 Reads
1.003 Impact Factor

A simple and sensitive HPLC-fluorescence method for the determination of moxifloxacin in human plasma and its application in a pharmacokinetic study.

Pharmazie 2018 11;73(11):625-629

A simple sample preparation technique coupled with the specific and sensitive fluorescence detection for the determination of moxifloxacin in human plasma was developed and fully validated. Levofloxacin was chosen as an internal standard. Chromatographic separation was achieved using a Shiseido C18 MGII (250×4. Read More

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http://dx.doi.org/10.1691/ph.2018.8148DOI Listing
November 2018
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CYP2C19 polymorphism in relation to the pharmacotherapy optimization of commonly used drugs.

Pharmazie 2018 11;73(11):619-624

: The CYP2C19 isoenzyme plays an important role in the efficacy and safe use of many drugs. The aim of this review is to demonstrate how mutations influence everyday patient treatment, leading to adverse drug reactions or therapy failure in many common diseases. : A PubMed literature search was performed on clinical publications evaluating the impact of on pharmacotherapy outcome. Read More

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http://dx.doi.org/10.1691/ph.2018.8689DOI Listing
November 2018
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Clinic-level factors associated with collaboration with community pharmacies in Japan.

Pharmazie 2018 09;73(9):545-552

The aim of this study was to clarify the clinic-level factors related to experiences of and attitudes toward collaboration with community pharmacies. We conducted a postal questionnaire survey of all clinics in Gifu, Japan, assessing the experiences and attitudes of representative clinical staff regarding the following activities in collaboration with community pharmacists: regional care meetings/service adjustment meetings, case study conferences, joint workshops/continuing education conferences, community services, information sharing through medical cooperation networks, and accompanying community pharmacists during home care. The factors significantly related to experiences of joint workshops/continuing education conferences included home care visits (odds ratio [OR] 2. Read More

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http://dx.doi.org/10.1691/ph.2018.8542DOI Listing
September 2018
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Anti-inflammatory effects of neferine on LPS-induced human endothelium MAPK, and NF-κβ pathways.

Pharmazie 2018 09;73(9):541-544

This study aimed to evaluate the anti-inflammatory mechanism of neferine, a bisbenzylisoquinoline alkaloid, on the lipopolysaccharide (LPS)-induced inflammation in Human Umbilical Endothelial Cells (HUVECs) and pulmonary aorta cells. Production of pro-inflammatory cytokines and nitric oxide (NO) was determined using Griess reaction in human endothelial cells. The levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and mitogen-activated protein kinases (MAPKs) were analyzed using real time PCR and western blotting. Read More

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http://dx.doi.org/10.1691/ph.2018.8443DOI Listing
September 2018
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