12,187 results match your criteria Die Pharmazie[Journal]


Acceptance of a medication refill reminder service in German community pharmacy practice.

Pharmazie 2019 Mar;74(3):186-190

Medication refill reminder services (MRRS), having the potential to support the detection of non-adherence and to promote periodic medication refilling by addressing forgetfulness, are not generally available in community pharmacy practice. Based on a new software module, a MRRS was developed. The acceptance of this service was tested in community pharmacies in Germany. Read More

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http://dx.doi.org/10.1691/ph.2019.8669DOI Listing

Adjuvant effect of leaf extract on host immune response to hepatitis B virus subunit vaccine.

Pharmazie 2019 Mar;74(3):179-185

Adjuvants can increase the efficiency and reduce the number of required doses for hepatitis B vaccination. Thus the study was designed to investigate whether leaf extract may be used as an adjuvant to the conventional hepatitis B surface antigen-based vaccine through humoral response analyses. The toxicity/safety margin of was determined using Lorke's method. Read More

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http://dx.doi.org/10.1691/ph.2019.8920DOI Listing

Micheliolide inhibits gastric cancer growth and blockade of the IL-6/STAT3 pathway.

Pharmazie 2019 Mar;74(3):175-178

Upregulation of pro-inflammatory cytokine interleukin (IL)-6 is observed in gastric cancer tissue, and high IL-6 serum levels predict a poor prognosis of gastric cancer patients. The IL-6/STAT3 pathway has been confirmed to play essential roles in the process of carcinogenesis, including gastric cancer. Thus, blockade of the IL-6/STAT3 pathway may be a potentially effective therapeutic option for gastric cancer. Read More

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http://dx.doi.org/10.1691/ph.2019.8816DOI Listing

Vitamin D suppresses lipopolysaccharide-induced inflammatory response in vascular smooth muscle cells inhibition of the p38 MAPK signaling pathway.

Pharmazie 2019 Mar;74(3):168-174

Inflammation and vascular smooth muscle cells (VSMCs) play key roles in the development of many cardiovascular diseases (CVDs). Although vitamin D decreases the risks of inflammation related diseases including CVDs, the links between vitamin D, VSMCs and vascular inflammation remained unclear. In this study, we investigated the anti-inflammatory effect and signaling pathways of vitamin D in lipopolysaccharide (LPS)-induced VSMCs. Read More

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http://dx.doi.org/10.1691/ph.2019.8818DOI Listing
March 2019
1.003 Impact Factor

Anti-tumor effects of resveratrol on malignant melanoma is associated with promoter demethylation of RUNX3 gene.

Pharmazie 2019 Mar;74(3):163-167

The natural phytoalexin resveratrol (RES) has exhibited excellent anti-tumor effects on a variety of tumors including malignant melanoma. However, its specific mechanism of anti-melanoma needs to be further explored. It has been reported, that the expression of tumor suppressor gene RUNX3 was lost or substantially decreased in melanoma. Read More

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http://dx.doi.org/10.1691/ph.2019.8838DOI Listing

Ginsenoside Rg1 inhibits myocardial ischaemia and reperfusion injury HIF-1 α-ERK signalling pathways in a diabetic rat model.

Pharmazie 2019 Mar;74(3):157-162

The aim of this study was to observe the effects of HIF-1α activation on myocardial I/R in diabetes. Diabetes was induced in an experimental rat model, and regulators of HIF-1α including KC7F2, deferoxamine and ginsenoside Rg1 were administered to observe the changes on diabetic rats. The results demonstrated that HIF-1α activation could effectively reduce myocardial injury following I/R in diabetic hearts ERK but not MMP-2 signalling pathways. Read More

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http://dx.doi.org/10.1691/ph.2019.8858DOI Listing

CBX1 is a direct target of miR-205-5p and contributes to the progression of pituitary tumor.

Pharmazie 2019 Mar;74(3):154-156

MicroRNAs (miRs) are crucial regulators for tumorigenesis through negatively regulating their target genes expression in the manner of 3'-untranslated region (3'-UTR) binding. MiR-205-5p has been reported to function as a tumor suppressor in several cancer types. The aim of this study was to investigate the role of miR-205-5p/chromobox homolog 1 (CBX1) axis in human pituitary tumors. Read More

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http://dx.doi.org/10.1691/ph.2019.8908DOI Listing
March 2019
2 Reads

AK-968 efficiently inhibits proliferation and induces cell apoptosis in human multiple myeloma cells.

Pharmazie 2019 Mar;74(3):150-153

AK-968 is a small molecular weight compound. In this study, we evaluated its anti-tumor effects on human multiple myeloma (MM) cells. Our results demonstrated that AK-968 markedly inhibited proliferation of MM cell lines in a dose-and time-dependent manner. Read More

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http://dx.doi.org/10.1691/ph.2019.8914DOI Listing
March 2019
1 Read

Effects of mirogabalin, a novel ligand for the α₂δ subunit of voltage-gated calcium channels, on N-type calcium channel currents of rat dorsal root ganglion culture neurons.

Pharmazie 2019 Mar;74(3):147-149

Mirogabalin, which is a novel ligand for the α₂δ subunit of voltage-gated calcium channels, is being developed for treating neuropathic pain including diabetic peripheral neuropathy and postherpetic neuralgia. Mirogabalin possesses unique α₂δ subunit binding characteristics and has potent and long-lasting analgesic effects in neuropathic pain models. In the present study, we investigated the effects of mirogabalin on N-type calcium channel currents of the rat dorsal root ganglion (DRG) culture neurons using the whole-cell patch clamp technique. Read More

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http://dx.doi.org/10.1691/ph.2019.8833DOI Listing
March 2019
1 Read

3-Aminobenzamide protects against cerebral artery injury and inflammation in rats with intracranial aneurysms.

Pharmazie 2019 Mar;74(3):142-146

This study aimed to investigate the treatment effects and molecular mechanism of 3-aminobenzamide (3-AB) on intracranial aneurysms (IA). The IA model was established in male Sprague-Dawley (SD) rats and sham group was set up without ligation. The rats were intraperitoneally injected with normal saline in sham and model control groups and 10 mg/kg, 20 mg/kg and 40 mg/kg 3-AB for low, middle and high 3-AB groups for 3 months, respectively. Read More

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http://dx.doi.org/10.1691/ph.2019.8911DOI Listing
March 2019
1.003 Impact Factor

Dermal peptide delivery using enhancer molecules and colloidal carrier systems - part V: Influence of enhancers on the permeation of PKEK through snake skin.

Pharmazie 2019 Mar;74(3):136-141

In a previous study, it was shown, that shed snake skin is a good alternative model membrane for the human stratum corneum (SC). In this study, the influence of the enhancers dimethyl sulfoxide (DMSO), 1,2-propanediol, 1,3-butanediol, 1,2-pentanediol, 1,2-hexanediol and 1,2-octanediol in a concentration of 10 % on the permeation of l-prolyl- l-lysyl-l-α-glutamyl-l-lysin (PKEK) through shed snake skin was conducted. Pharmacokinetic parameters (diffusion coefficient, permeation coefficient, t-lag, Flux) were calculated. Read More

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http://dx.doi.org/10.1691/ph.2019.8105DOI Listing

Effect of the rigidification of propranolol, a mixed -adrenoceptor and 5-HTR antagonist.

Pharmazie 2019 Mar;74(3):131-135

Propranolol is a popular β adrenergic antagonists that, together with pindolol, binds also to serotoninergic receptors, namely 5-HT. In this work the rigidification of the propranolol structure by locking its hydroxyl group within a 1,3-dioxolane ring was investigated. Constrained derivatives of propranolol were synthesized, fully characterized and tested for their affinity at β-adrenoreceptors and 5-HT receptors using radioligand binding assay. Read More

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http://dx.doi.org/10.1691/ph.2019.8878DOI Listing

Evaluation of the compliance with antiemetic guidelines for prevention of chemotherapy-induced nausea and vomiting in patients with hematologic malignancy.

Pharmazie 2019 Apr;74(4):250-254

To assess compliance with the Japanese antiemetic guidelines for chemotherapy-induced nausea and vomiting (CINV), the frequencies of CINV occurrence and use of antiemetic rescue medications were examined in patients with hematological malignancy. A total of 40 patients with hematologic malignancy were eligible in this study. This study was performed in the Department of Hematology, Kyushu University Hospital, as a subgroup analysis from a nationwide, multicenter prospective cohort study conducted by the CINV Study Group of Japan. Read More

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http://dx.doi.org/10.1691/ph.2019.8889DOI Listing

MicroRNA-2861 targets STAT3 and MMP2 to regulate the proliferation and apoptosis of ectopic endometrial cells in endometriosis.

Pharmazie 2019 Apr;74(4):243-249

This study aimed to elucidate the roles and regulatory mechanism of miR-2861 in the development of endometriosis. The expression of miR-2861 in endometriotic tissues and eutopic endometrial tissues was determined. Ectopic endometrial cells were transfected with miR-2861 mimic, miR-2861 inhibitor and their corresponding controls. Read More

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http://dx.doi.org/10.1691/ph.2019.8881DOI Listing
April 2019
3 Reads

The dipeptidyl peptidase-4 inhibitor sitagliptin ameliorates renal injury in type 1 diabetic mice inhibiting the TGF-β/Smad signal pathway.

Pharmazie 2019 Apr;74(4):239-242

Diabetic nephropathy (DN) is a common cause of end-stage kidney disease (ESKD) all over the world. Sitagliptin, an inhibitor of DPP-IV plays a beneficial role in type 2 diabetic nephropathy. The purpose of this study was to explore the effect and mechanism of sitagliptin on renal injury in type 1 diabetic mice. Read More

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http://dx.doi.org/10.1681/ph.2019.8918DOI Listing
April 2019
2 Reads

MiR-758-3p regulates papillary thyroid cancer cell proliferation and migration by targeting TAB1.

Pharmazie 2019 Apr;74(4):235-238

Previous studied revealed that miR-758-3p was abnormally expressed in cancer patients. However, its role and underlying mechanism in papillary thyroid cancer (PTC) remains unclear. Expression of miR-758-3p in PTC cell lines was analyzed using quantitative real-time PCR. Read More

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http://dx.doi.org/10.1691/ph.2019.8933DOI Listing
April 2019
4 Reads

Neuregulin-1 protects cardiac electrical conduction through downregulating matrix metalloproteinase-9 and upregulating connexin 43 in a rat myocardial infarction model.

Pharmazie 2019 Apr;74(4):231-234

Neuregulin-1 (NRG-1) is a member of the epidermal growth factor family, and has an important role in cardiomyocyte development and myocardial regeneration. The aim of this study was to determine the protective effect of NRG-1 on cardiac electrical conduction in a rat myocardial infarction (MI) model. Thirty-three adult male SPF SD rats were randomized into three groups: sham-operated (n=9), acute myocardial infarction (AMI, n=12), and the NRG-1-treated (NRG-1, n=12) groups. Read More

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http://dx.doi.org/10.1691/ph.2019.8941DOI Listing
April 2019
2 Reads

Disintegration time of orally dissolving films: various methodologies and correlation.

Authors:
M Saab M M Mehanna

Pharmazie 2019 Apr;74(4):227-230

Orodispersible films (ODF) have gained a remarkable success in the market, especially in pediatric and geriatric populations. The time required for an ODF to disintegrate is an essential quality and safety feature, thus an appropriate methodology is crucial. The USP disintegration apparatus is not appropriate for ODFs, as the determination of the end point is challenging and may not predict disintegration time. Read More

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http://dx.doi.org/10.1691/ph.2019.8231DOI Listing
April 2019
1 Read

Development and chemical characterization of biodegradable polymeric implants containing sirolimus for the treatment of malignant solid tumors.

Pharmazie 2019 Apr;74(4):221-226

The use of sirolimus and its analogs has been evaluated in studies aimed at combating several types of cancer; however, because of the limited bioavailability of the drug, the search for new forms of administration is required. Biodegradable polymeric implants containing sirolimus were developed and assessed as an alternative method of drug administration. Implants containing 25 % (w/w) sirolimus were prepared employing the polymer matrices chitosan, polycaprolactone and poly(lactic-co-glycolic acid) (PLGA) in two proportions: PLGA 50:50 and PLGA 75:25. Read More

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http://dx.doi.org/10.1691/ph.2019.8201DOI Listing
April 2019
5 Reads

Intra-articular leflunomide-loaded poly(ε-caprolactone) implants to treat synovitis in rheumatoid arthritis.

Pharmazie 2019 Apr;74(4):212-220

Rheumatoid arthritis is an autoimmune pathology that manifests as chronic inflammatory arthropathy and synovitis. Treatment of rheumatoid arthritis is based on the administration of different types of drugs, including leflunomide, an antirheumatic drug. However, the long-term systemic use of leflunomide may be associated with adverse effects. Read More

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http://dx.doi.org/10.1691/ph.2019.8223DOI Listing

An HPLC-DAD validated method for the detection and quantification of cortisol, corticosterone and melatonin in plasma samples of two different animal species.

Pharmazie 2019 Apr;74(4):206-211

The monitoring of endogenous hormone plasma levels could be valuable in biomedical, veterinary and pharmaceutical research. A specific high performance liquid chromatography method with diode array detection, for the assay of cortisol, corticosterone and melatonin in animal plasma was developed and validated. The chromatographic separation was achieved on a C reversed phase column with a mobile phase consisting of HPLC-grade water and 35% v/v acetonitrile (pH ± 3. Read More

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http://dx.doi.org/10.1691/ph.2019.8225DOI Listing
April 2019
1 Read

Effect of desflurane-remifentanil or sevoflurane-remifentanil on early recovery in elderly patients: a meta-analysis of randomized controlled trials.

Pharmazie 2019 Apr;74(4):201-205

: We conducted a meta-analysis to evaluate different indexes of the postoperative resuscitation period in elderly patients who received desflurane-remifentanil or sevoflurane-remifentanil. : A systematic search of the PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure and Wanfang databases for randomized controlled trials (RCTs) of elderly patients who received desflurane-remifentanil or sevoflurane-remifentanil was conducted. Extracted data were analysed using RevMan version 5. Read More

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http://dx.doi.org/10.1691/ph.2019.8935DOI Listing
April 2019
2 Reads

Therapeutic approach to chronic venous insufficiency - clinical benefits of red-vine-leaf-extract AS 195 (Antistax).

Pharmazie 2019 Apr;74(4):193-200

Chronic Venous Disorders or Diseases (CVD) of the lower extremities are a common finding affecting almost 90 % of an adult population. CVD includes varicose veins with a prevalence of approx. 25 %, overlapping with Chronic Venous Insufficiency (CVI) with a prevalence of approx. Read More

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http://dx.doi.org/10.1691/ph.2019.9326DOI Listing
April 2019
2 Reads

Association between polymorphism and hypospadias: a meta-analysis.

Pharmazie 2019 02;74(2):125-128

Steroid 5a-reductase type-2 () has been reported to be associated with hypospadias, but the available results are not consistent across studies. Therefore, we conducted a comprehensive meta-analysis to systematically review the association between gene polymorphisms and hypospadias. Public databases PubMed and Embase were searched before March 1, 2016. Read More

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http://dx.doi.org/10.1691/ph.2019.8768DOI Listing
February 2019
1.003 Impact Factor

Risk factors for decreased teicoplanin trough concentrations during initial dosing in critically ill patients.

Pharmazie 2019 02;74(2):120-124

Here, we investigated the risk factors for decreased teicoplanin plasma trough concentrations relative to the initial dosing in critically ill patients. Data obtained from 80 eligible critically ill patients who received intravenous teicoplanin were retrospectively analyzed. Risk factors for decreases in teicoplanin trough concentrations 72 h after administration of teicoplanin of more than 30% relative to predicted concentrations based on initial dosing setting were identified by logistic regression analysis. Read More

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http://dx.doi.org/10.1619/ph.2019.8731DOI Listing
February 2019

Cyclic adenosine phosphate improves functional recovery after spinal cord injury via activating unfolded protein response.

Pharmazie 2019 02;74(2):115-119

The current study aimed to evaluate the role and underlying mechanism of cyclic adenosine phosphate (cAMP) on the functional recovery of spinal cord injury (SCI). Basso, Beattie and Bresnahan (BBB) scoring and inclined plane test indicated that cAMP treatment improved the functional recovery of SCI rats. Real time PCR and western blot analysis showed the mRNA and protein levels of IRE1, PERK, and ATF6 were increased in the SCI rats than those of sham control. Read More

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http://dx.doi.org/10.1691/ph.2019.8347DOI Listing
February 2019

MiR-761 inhibits colorectal cancer cell proliferation and invasion through targeting HDAC1.

Pharmazie 2019 02;74(2):111-114

Colorectal cancer (CRC) is one of the most common cancer diagnoses. Histone deacetylase (HDAC) overactivity in CRC could promote cancer progression. HDAC1, a member of the HDAC family, is found aberrantly expressed in CRC, but it remains unclear whether the expression of HDAC1 can be regulated by microRNA. Read More

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http://dx.doi.org/10.1691/ph.2019.8756DOI Listing
February 2019
1 Read

The involvement of blood cells in the phosphorylation of the selective sphingosine-1-phosphate receptor 1 agonist SYL-927.

Pharmazie 2019 02;74(2):107-110

SYL-927 is a selective sphingosine-1-phosphate receptor 1 (S1P) agonist for autoimmune diseases. It undergoes phosphorylation to the active SYL-927-P , which activates S1P on lymphocytes, causing lymphopenia by retention of lymphocytes in the lymph nodes. The aim of this study was to identify the involvement of blood cells in the phosphorylation of SYL-927. Read More

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http://dx.doi.org/10.1691/ph.2019.8809DOI Listing
February 2019
1.003 Impact Factor

Paeonol ameliorates lipopolysaccharides-induced acute lung injury by regulating TLR4/MyD88/ NF-κB signaling pathway.

Pharmazie 2019 02;74(2):101-106

Paeonol has been found to hold analgesic, antipyretic and anti-allergic activities. Here, we investigated the protective effect of paeonol on acute lung injury (ALI) induced by lipopolysaccharides (LPS) and explored the underlying mechanisms on TLR4/MyD88/NF-κB signaling pathway. C57BL/6 mice were randomly divided into control (normal saline, NS, 0. Read More

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http://dx.doi.org/10.1691/ph.2019.8860DOI Listing
February 2019

Bioavailability of moclobemide from two formulation tablets in healthy humans.

Pharmazie 2019 02;74(2):97-100

A ,,sine qua non" requirement for a generic formulation to be admitted for a medical use is to provide bioavailability studies in healthy subjects. Therefore, those studies were performed for 150 mg moclobemide tablets (Jelfa, Poland) versus 150 mg Aurorix (Hoffmann la Roche) reference tablets. An open-label, two-phase crossover study was conducted with 10 healthy subjects. Read More

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http://dx.doi.org/10.1691/ph.2019.8819DOI Listing
February 2019

Development, manufacture and characterization of niosomes for the delivery for nevirapine.

Pharmazie 2019 02;74(2):91-96

Nevirapine (NVP), used for the treatment of HIV/AIDS, exhibits unpredictable oral bioavailability, has a poor side effect profile and requires frequent dosing. Niosomes are novel drug delivery systems that have the potential to overcome these challenges. A thin layer hydration approach was used to produce niosomes and optimisation was undertaken using design of experiments (DoE) and response surface methodology (RSM) establish and identify parameters that may affect the manufacture of niosomes. Read More

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http://dx.doi.org/10.1691/ph.2019.8168DOI Listing
February 2019
2 Reads

Hyaluronic acid-coated single-walled carbon nanotubes loaded with doxorubicin for the treatment of breast cancer.

Pharmazie 2019 02;74(2):83-90

Hyaluronic acid (HA)-modified amino single-walled carbon nanotubes (NH₂-SWCNTs) were developed for targeted delivery of doxorubicin (DOX) to improve breast cancer treatment. HA, which specifically binds to the CD44 receptor, was non-covalently coated on NH₂-SWCNTs through simply electrostatic adsorption. The formed SWCNTs-DOX-HA complexes were characterized in terms of morphology, particle size and zeta potential by different techniques. Read More

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http://dx.doi.org/10.1691/ph.2019.8152DOI Listing
February 2019
2 Reads
1.003 Impact Factor

Simplified LC-MS/MS method for quantification of IG-105, a novel tubulin ligand, and its application to the pharmacokinetic study in rats at the anticancer effective dose.

Pharmazie 2019 02;74(2):79-82

IG-105, N-(2, 6-dimethoxypyridine-3-yl)-9-methylcarbazole-3-sulfonamide, a novel carbazole sulfonamide, shows a potent anticancer activity in a variety of human tumor cells and . In the present study, a rapid and convenient liquid chromatography/tandem mass spectrometry (LC-MS/MS) method was developed and applied to the pharmacokinetic study of IG-105 in rats. Chromatographic separation was accomplished on a C column using an isocratic mobile phase of acetonitrile-water-acetic acid (56:44:0. Read More

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http://dx.doi.org/10.1691/ph.2019.8157DOI Listing
February 2019
1 Read

Synthesis and antibacterial activity of novel icariin derivatives.

Authors:
A Wang Y Xu

Pharmazie 2019 02;74(2):73-78

A series of aromatic sulfonyls substituted icariin derivatives was synthesized and their antibacterial activities against (including drug-sensitive bacteria and drug-resistant bacteria) were evaluated. Among them, compound exhibited high potency against methicillin-sensitive (MSSA) and resistant strains of (MRSA) with MIC values of 1-2 mmol/L. Reverse virtual screening and molecule docking analysis indicated that compound might bind the allosteric site of PBP2a that may inhibit cell wall synthesis, with the advantage of activity against multidrug resistant SPR experiment further confirmed the binding affinity. Read More

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http://dx.doi.org/10.1691/ph.2019.8866DOI Listing
February 2019
1 Read

Biological activity and health promoting effects of psoralidin.

Pharmazie 2019 02;74(2):67-72

Psoralidin, a prenylated coumestrol isolated from the seed of a traditional Chinese medicine L., has been demonstrated to exhibit anti-inflammatory, anti-cancer, anti-oxidative, estrogenic, neuroprotective, anti-bacterial, and anti-parasite activities. Due to prenylation, psoralidin exhibits stronger estrogenic activity with no obvious adverse effects and shows a close association with management of osteoporosis and some cancers. Read More

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http://dx.doi.org/10.1691/ph.2019.8619DOI Listing
February 2019
3 Reads

A case of under-dosing after raltegravir formulation change in an elderly patient treated for HIV.

Pharmazie 2019 01;74(1):62-63

Our case was a 70-year-old male (height: 168 cm, weight: 74.3 kg) with polypharmacy (total 15 drugs including 10 tablets) who was treated for HIV infection. His dosing schedule of raltegravir was changed from BID (a 400 mg tablet, twice) to QD (2x600 mg tablet, once). Read More

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http://dx.doi.org/10.1691/ph.2019.8788DOI Listing
January 2019
2 Reads

Cyanidin-3--glucoside chloride acts synergistically with luteolin to inhibit the growth of colon and breast carcinoma cells.

Pharmazie 2019 01;74(1):54-61

In this study, we investigated whether the combination of cyanidin-3--glucoside chloride and luteolin could inhibit the growth of HCT-8 colon and MCF-7 breast carcinoma cells, and whether the effect of the combination was greater than the effect of either drug on its own. Growth inhibition was assessed using the CCK-8 assay, level of apoptosis and cell cycle distribution were determined using flow cytometry, and the mechanism of apoptosis induction was explored using a colorimetric assay of caspases-3 and -9. Experiments indicated that combination treatment inhibited proliferation and increased apoptosis in both cell lines to a greater extent than either drug on its own. Read More

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http://dx.doi.org/10.1691/ph.2019.8746DOI Listing
January 2019
3 Reads

Improved gastrointestinal stability of solid lipid nanoparticles using comb-shaped amphiphilic inulin derivatives.

Pharmazie 2019 01;74(1):47-53

In order to reduce enzymatic degradation and thereby enhance the stability of solid lipid nanoparticles (SLNs) in the gastrointestinal tract, comb-shaped amphiphilic macromolecular material (CAM) of dodecyl inulin (Inu12) and octadecyl inulin (Inu18) were designed as the emulsifier and stabilizer to modify SLNs (Inu12/Inu18-SLNs). Inu12-SLNs and Inu18-SLNs had similar particle size as the control SLNs (P188-SLNs and Tween-SLNs) prepared with the straight chain surfactants, poloxamer 188 and tween-80 as the emulsifier, which ranged from 220 nm to 270 nm. The zeta potentials of all the SLNs formulations were slightly negative. Read More

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http://dx.doi.org/10.1691/ph.2019.8140DOI Listing
January 2019
1 Read
1.003 Impact Factor

Intranasal administration of pullulan-based nanoparticles for enhanced delivery of adriamycin into the brain: and evaluation.

Pharmazie 2019 01;74(1):39-46

Intranasal (i.n.) administration is an efficient route for enhancing drug delivery to the brain, bypassing the blood-brain barrier (BBB) and eliminating systemic side effects. Read More

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http://dx.doi.org/10.1691/ph.2019.8124DOI Listing
January 2019
2 Reads

Nystatin antifungal micellar systems on endotracheal tubes: development, characterization and evaluation.

Pharmazie 2019 01;74(1):34-38

Decontamination of patients' clinical devices in intensive care units is generally performed with an antifungal suspension. Nystatin is a widely-used high spectrum antifungal due to its low systemic absorption. However, nystatin has high hydrophobicity which hinders the contact with the internal lumen of the devices. Read More

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http://dx.doi.org/10.1691/ph.2019.8138DOI Listing
January 2019
3 Reads

Species-specificity in the interaction of IgE with FcεRI between humans and rats.

Pharmazie 2019 01;74(1):29-33

The interaction of immunoglobulin E (IgE) to its high-affinity receptor (FcεRI) plays a key role in triggering allergic reactions. However, it is still controversial whether species specificity influences the binding ability between humans and rodents. Recombinant hFcεRIα / RBL-2H3 and hFcεRIα / MGC-803 cells were prepared and sensitized with hIgE/anti-hIgE antibody or DNP-IgE/DNP-BSA, respectively. Read More

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http://dx.doi.org/10.1691/ph.2019.8771DOI Listing
January 2019
6 Reads

Long noncoding RNA SNHG6 contributes to ventricular septal defect formation via negative regulation of miR-101 and activation of Wnt/β-catenin pathway.

Pharmazie 2019 01;74(1):23-28

This study aimed to investigate the role and regulatory mechanism of small nucleolar RNA host gene 6 (SNHG6), a long noncoding RNA, in the formation of ventricular septal defect (VSD). The expression of SNHG6 in fetal cardiac tissues with VSD, mouse heart embryo development and the differentiation of P19 cells into cardiomyocytes were determined. Moreover, the effect of aberrant expression of SNHG6 on P19 cell proliferation, cell cycle, apoptosis and differentiation was further analyzed to explore the role of SNHG6 in affecting myocardial development. Read More

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http://dx.doi.org/10.1691/ph.2019.8736DOI Listing
January 2019
1 Read

Differential pulse polarographic investigation of micafungin and anidulafungin using a dropping mercury electrode.

Pharmazie 2019 01;74(1):18-22

The electrochemical behavior of the echinocandin antifungals anidulafungin (AF) and micafungin (MF) has been investigated by differential pulse polarography (DPP). The measurements were carried out in a supporting electrolyte solution consisting of Britton-Robinson buffer and methanol at various substance concentrations and pH values. An amperometric cell with a three electrode system consisting of a dropping mercury electrode (DME) as working electrode, an auxiliary platinum electrode and an Ag/AgCl reference electrode was used in all experiments. Read More

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http://dx.doi.org/10.1691/ph.2019.8680DOI Listing
January 2019

Synthesis of phenylpyrimidinones as guanylyl cyclase C inhibitors.

Pharmazie 2019 01;74(1):15-17

Diarrhea is one of the most important causes of mortality in the developing world, being responsible for 2.5 million deaths each year. Many of these deaths are caused by enterotoxigenic strains of bacteria, like that produce enterotoxins that cause acute watery diarrhea, commonly defined as secretory diarrhea. Read More

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http://dx.doi.org/10.1691/ph.2019.8775DOI Listing
January 2019

Efficacy and safety of different doses of alirocumab in reducing low-density lipoprotein cholesterol levels: a network meta-analysis.

Pharmazie 2019 01;74(1):8-14

This study aimed to conduct a network meta-analysis of the efficacy and safety of different doses of alirocumab in reducing low-density lipoprotein cholesterol levels. In the present study, a total of 16 studies were selected, published between January 2012 and October 2016. Pair-wise and network meta-analyses was used to carry out a direct and indirect comparison of the three treatment strategies of alirocumab in patients with hypercholesterolemia. Read More

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http://dx.doi.org/10.1691/ph.2019.8584DOI Listing
January 2019

Targeting HIF-1α signaling pathway for gastric cancer treatment.

Pharmazie 2019 01;74(1):3-7

Gastric cancer is a common malignancy with high mortality and limited therapeutic options. Hypoxia inducible factor-1 α (HIF-1α) is the key responser adapted to tumor hypoxia. Under hypoxia conditions, HIF-1α signaling is activated and responsible for cell biology associated with metabolism, inflammation, vascular homeostasis and tumorigenesis. Read More

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http://dx.doi.org/10.1691/ph.2019.8674DOI Listing
January 2019

Relationship between the administration of nicardipine hydrochloride and the development of delirium in patients on mechanical ventilation.

Pharmazie 2018 12;73(12):740-743

A history of hypertension is a known risk factor for delirium in patients in intensive care units, but the effect of antihypertensive agents on delirium development is unclear. Nicardipine, a calcium channel blocker, is widely used in ICU as a treatment agent for hypertensive emergency. This study investigated the relationship between the administration of nicardipine hydrochloride and delirium development in patients under mechanical ventilation. Read More

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http://dx.doi.org/10.1691/ph.2018.8711DOI Listing
December 2018
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Applicability of hemodialysis clearance parameter for vancomycin therapeutic drug monitoring during continuous hemodiafiltration in an infant.

Pharmazie 2018 12;73(12):737-739

Cases requiring vancomycin administration planning in infants undergoing continuous hemodiafiltration (CHDF) are extremely rare. Here, we report a single case in which vancomycin therapeutic drug monitoring and administration planning were implemented for an infant requiring CHDF. The patient was diagnosed with wound infection after gastrostomy and enterotomy surgery and received vancomycin treatment for infection with methicillin-resistant . Read More

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http://dx.doi.org/10.1691/ph.2018.8748DOI Listing
December 2018
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Antiviral activity of propolis special extract GH 2002 against virus .

Pharmazie 2018 12;73(12):733-736

Propolis is a generic name for a biological substance produced by bees used for multiple purposes in folk medicine. Propolis special extract GH 2002 is crude propolis highly purified by a special procedure and freed from the accompanying substances like pollen, wax, resins. The cytotoxic and antiherpetic effect of propolis extracts against virus (VZV) was analysed in cell culture, and revealed a moderate cytotoxicity on lung fibroblasts with a CC of 380 μg/ml. Read More

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http://dx.doi.org/10.1691/ph.2018.8672DOI Listing
December 2018
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Retinoic acid increases the anticancer effect of paclitaxel by inducing differentiation of cancer stem cells in melanoma.

Authors:
Y B Wang B Sun B Han

Pharmazie 2018 12;73(12):729-732

Malignant melanoma is a highly lethal disease, and advanced stages of melanoma have proven to be resistant to many chemotherapeutic drugs including temozolomide and paclitaxel. Cancer stem cells (CSCs) have been identified and isolated in different cancers including melanoma, and have been proven playing important role in the drug resistance. Retinoic acid (RA) is a promising anticancer agent, which can induce differentiation of CSCs. Read More

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http://dx.doi.org/10.1691/ph.2018.8715DOI Listing
December 2018
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