49,377 results match your criteria Die Medizinische Welt[Journal]


[Update of multimodal therapy in canine osteoarthritis].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):337-345. Epub 2018 Dec 12.

Canine osteoarthritis is a very common disease and the main cause for chronic pain in dogs. Progressive degeneration of joint cartilage, periarticular soft tissues and subchondral bone consecutively lead to osteophytes, inflammation and pain. It is an irreversible process. Read More

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October 2018

Update on therapy and prevention of canine leishmaniasis.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):315-322. Epub 2018 Dec 12.

Canine leishmaniasis is an emerging infection with increasing importance because the main vector also exists in Germany and autochthonous infections have been described. In this article we present the latest information available regarding therapy and prevention of this disease. Allopurinol-resistant strains were isolated from dogs which experienced recurrent disease while being treated with allopurinol, highlighting the need for alternative treatment options. Read More

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October 2018
1 Read

[Cobalamin deficiency in dogs and cats].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):309-314. Epub 2018 Dec 12.

Cobalamin is a member of the B-group of vitamins and a cofactor for metabolic processes like nucleic acid synthesis, amino acid synthesis, and the citric acid cycle. Mammals are unable to synthesize cobalamin and therefore rely on adequate food intake. Cobalamin absorption is a complex process in the stomach, duodenum, and ileum, requiring a functional exocrine pancreas. Read More

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October 2018
1 Read

Effect of an insect protein-based diet on clinical signs of dogs with cutaneous adverse food reactions.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):297-302. Epub 2018 Dec 12.

Objective: Edible insects (like mealworms, locusts and crickets) contain energy, protein, fatty acids, minerals and trace elements and have been found to be high quality food sources. They could provide a new food source for patients with adverse food reactions, as well as being of ecological and ethical interest. The aim of this study was to evaluate the effect of a new commercially available, insect protein-based diet on the clinical signs in those dogs via Canine Atopic Dermatitis Lesion Index (CADLI), Pruritus Visual Analogue Scale (PVAS) and coat quality score. Read More

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October 2018
1 Read

[Diagnostic value of the BRAF variant V595E in urine samples, smears and biopsies from canine transitional cell carcinoma].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):289-295. Epub 2018 Dec 12.

Objective: Transitional cell carcinoma (TCC) is the most common malignant tumour of the canine urinary tract. Previously, the mutation of the BRAF gene V595E was identified in approximately 85 % of canine TCC cases by DNA sequencing of TCC tumour cells, both in frozen and paraffin-embedded tissue sections, as well as in urine. The objective of this study was to establish these methods in cytological smears and to investigate the prevalence of BRAF mutation V595E in canine TCC in our cohort of patients. Read More

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October 2018

[Natural history after discharge from a hospital psychosomatic treatment - Results of a one-year follow-up].

Fortschr Neurol Psychiatr 2018 Dec 12. Epub 2018 Dec 12.

Zentrum für Psychiatrie Südwürttemberg, Abteilung Psychosomatische Medizin Ravensburg.

Background: The effectiveness of the inpatient psychosomatic treatment has been documented in various settings. The question of the sustainability of the improvement achieved as well as the prognostic factors is of interest for public health.

Objective: Primary outcome variables reflect the stability or change in the clinical status of patients one year after the discharge from the inpatient psychosomatic treatment. Read More

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December 2018

[The Influence of Residence Status on Psychiatric Symptom Load of Asylum Seekers in Germany].

Psychiatr Prax 2018 Dec 12. Epub 2018 Dec 12.

Psychiatrische Universitätsklinik der Charité im St. Hedwig-Krankenhaus Berlin.

Background: The aim of this study was to assess asylum seekers' views on their legal situations, asylum procedures and living conditions, and the relationship of these factors towards psychological stress.

Methods: 650 asylum seekers in Berlin received a questionnaire.

Results: 76,3 % (N = 496) completed the questionnaires in full. Read More

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December 2018
1 Read

[Interagency Cooperation in a Community Mental Health Centre - A Qualitative Study about the Stakeholders' Experiences].

Psychiatr Prax 2018 Dec 12. Epub 2018 Dec 12.

Fachbereich Sozialwesen, Hochschule Niederrhein, University of Applied Sciences, Mönchengladbach.

Objective: This study explores the conditions for the stakeholders' cooperation in an integrative care model for people with psychosocial problems.

Methods: Expert interviews on various community mental health care providers were led and content analyzed.

Results: Joint objectives and conceptually comparable financing models were found to be essential for cooperation across mental health and social integration services. Read More

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December 2018

[A Reversible Case of Korsakoff Syndrome in an Alcohol Dependent Patient].

Psychiatr Prax 2018 Dec 12. Epub 2018 Dec 12.

LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine-Universität, Medizinische Fakultät Düsseldorf.

Alcohol dependent patients represent a high-risk group for vitamin deficiency, which could lead to variable cognitive dysfunctions and, as an extreme example, to an amnestic-confabulatory syndrome. In this case report, we report about an alcohol dependent 58-year-old patient without focal neurological symptoms with an amnestic-confabulatory syndrome. After substitution of thiamine, vitamin B12 and folic acid, cognitive symptoms completely vanish within a 22-month period of observation. Read More

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December 2018

[Current trends in flexible ureteroscopy: an update].

Aktuelle Urol 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg.

Flexible ureteroscopy (fURS) has become a success story in urology. Since its implementation into the treatment of urolithiasis, fURS has demonstrated excellent clinical performance and safety. In recent years, the spread of disposable ureteroscopes has shaped the field of endoscopic stone treatment. Read More

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December 2018
1 Read

[Biomechanical aspects of preoperative planning: What is really important?]

Authors:
F Völlner J Grifka

Orthopade 2018 Dec 11. Epub 2018 Dec 11.

Orthopädische Klinik für die Universität Regensburg, Asklepios Klinikum Bad Abbach, Kaiser-Karl-V-Allee 3, 93077, Bad Abbach, Deutschland.

Background: Sagittal balance is dependent on a complex interplay of the spinal curves, shape and setting of the pelvis, but also the position of the joints of the lower limb. Degenerative processes such as stiffening of the spine, aging of musculature, or reduction of the range of motion of the joints lead to imbalance of the spine after all compensatory mechanisms have been exhausted.

Objectives: Based on standardized imaging, compensation mechanisms must be identified within a biomechanical analysis of the spine, the original sagittal spine profile anticipated and included in the planning of the corrective intervention. Read More

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December 2018
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Femoral neck fractures in old age treated with hemiarthroplasty : Effects of preoperative waiting time and timing of surgery on the risk of periprosthetic infections.

Orthopade 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopedic Surgery, Traumatology and Plastic Surgery, University Hospital Leipzig, Liebigstraße 20, 04103, Leipzig, Germany.

Background: Hemiarthroplasty is an established treatment for femoral neck fractures (FNF) in old age; however, approximately 20-30% of patients die within 1 year after surgery. Periprosthetic joint infections (PJI) are one of the severest complications and associated with a high mortality rate. In this retrospective study of aged patients with FNF treated with hemiarthroplasty, the incidence of PJI was evaluated with respect to the influence of the delay to and timing of surgical treatment. Read More

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December 2018

Contribution of vegetables and cured meat to dietary nitrate and nitrite intake in Italian population: Safe level for cured meat and controversial role of vegetables.

Ital J Food Saf 2018 Sep 7;7(3):7692. Epub 2018 Nov 7.

Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati", Perugia (PG), Italy.

Nitrate and nitrite content was determined on a total of 900 samples of vegetables and cured meat and the nitrite and nitrate exposure assessment was evaluated for central Italy population based on the food consumption data reported by the national dietary surveys. The highest average content of nitrate was detected in rocket salad (4415 mg/kg) and radish (3817 mg/kg) and for cured meat in "Bresaola" (188 mg/kg) and in Bacon (178 mg/kg). The nitrite content was negligible both in vegetables than in cured meat. Read More

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September 2018

Data on whole genome sequencing of the oomycete Pythium insidiosum strain CBS 101555 from a horse with pythiosis in Brazil.

BMC Res Notes 2018 Dec 11;11(1):880. Epub 2018 Dec 11.

Research Center, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Objectives: The oomycete Pythium insidiosum infects humans and animals worldwide, and causes the life-threatening condition, called pythosis. Most patients lose infected organs or die from the disease. Comparative genomic analyses of different P. Read More

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December 2018

Specialized pediatric palliative care services for children dying from cancer: A repeated cohort study on the developments of symptom management and quality of care over a 10-year period.

Palliat Med 2018 Dec 12:269216318818022. Epub 2018 Dec 12.

1 Paediatric Palliative Care Centre and German Paediatric Pain Centre, Children's and Adolescents' Hospital, Datteln, Germany.

Background:: About one quarter of children affected with cancer die. For children and their families, the end-of-life period is highly distressing.

Aim:: This study focused on how end-of-life care in pediatric cancer patients changed over a period of 10 years and if changes in pediatric palliative care structures were associated with quality of care. Read More

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December 2018

Cooperation between Heart Failure Center of Hiroshima University Hospital and a regional medical facility: Option for an end-of-life heart failure patient receiving palliative care.

J Cardiol Cases 2014 Feb 13;9(2):75-79. Epub 2013 Dec 13.

Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Japan.

A 64-year-old woman with recurrent mitral valve stenosis was hospitalized 30 years after open commissurotomy. Severe right cerebral embolism occurred at age 58, with left hemiparesis. She was debilitated with cardiac cachexia. Read More

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February 2014

Complete AV block and cardiac syncope in a patient with Duchenne muscular dystrophy.

J Cardiol Cases 2011 Apr 16;3(2):e68-e70. Epub 2011 Feb 16.

Akdeniz University Faculty of Medicine, Cardiology Department, Dumlupinar Bouleward, Konyaaltı, Antalya, Turkey.

Duchenne muscular dystrophy is an X linked hereditary progressive neuromuscular disease and it is characterized by development of weakness and atrophy in affected muscles. In late phases of disease with involvement of respiratory and cardiac muscles, patients die because of respiratory and cardiac failure. Cardiomyopathy is a common complication and various types of arrhythmia because of conduction system involvement can be seen. Read More

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[Consult Your Physician or Health Care Provider? Health and Legal Aspects Regarding the Use of Dietary Supplements Offered in the World Wide Web].

Sportverletz Sportschaden 2018 Dec 11;32(4):264-271. Epub 2018 Dec 11.

Hochschule für öffentliche Verwaltung und Finanzen Ludwigsburg.

Background:  In Germany, widespread use is made of dietary supplements (DS) to improve the individual health status, especially among patients diagnosed with certain conditions, elderly people and athletes. Legal aspects as well as health risks related to DS purchased via the internet are rarely analysed in Germany.

Purpose:  We aim to provide a review of the respective literature focusing on health risks, legal aspects und consumer information related to the internet retailing of DS. Read More

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December 2018
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[Endovascular Therapy of Splanchnic Artery Aneurysms: For Each and Every Aneurysm?]

Zentralbl Chir 2018 Dec 11. Epub 2018 Dec 11.

Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Jena, Deutschland.

True visceral artery aneurysms (VAA) and visceral artery pseudoaneurysms (VAPA) are located in the celiac trunk, the superior mesenteric artery and inferior mesenteric artery. In addition to surgical treatment, endovascular embolisation therapy of visceral aneurysms and pseudoaneurysms is an alternative interventional method that has developed precipitously over the last two decades and is considered a first-choice method in many centres. The procedure is characterised by a high technical success rate with a low complication rate. Read More

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December 2018

[Use of Negative Pressure Wound Therapy with Instillation and Dwell Time for Wound Treatment - Results of an Expert Consensus Conference].

Zentralbl Chir 2018 Dec 11;143(6):609-616. Epub 2018 Dec 11.

Unfallchirurgie, Bundeswehrkrankenhaus Berlin, Deutschland.

Rinsing wounds with wound cleansing solutions has long been a recognised cornerstone in wound management as a means of removing cell debris and surface pathogens in wound exudates. In combination with surgical debridement and topical negative pressure wound therapy (NPWT), this can facilitate the intended progression from the inflammatory to the proliferative phase of wound healing. Procedures of topical negative pressure wound therapy with instillation and a defined exposure/dwell-time of topical solutions under cyclic compression and decompression with foam dressings (NPWTi-d) can remove cellular remnants and debris that may inhibit the healing process. Read More

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December 2018
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[Value of sialendoscopy in German ENT-hospitals in 2016].

Laryngorhinootologie 2018 Dec 11. Epub 2018 Dec 11.

Universitatsklinikum Giessen und Marburg Standort Giessen HNO.

Objective: In 2009 a nationwide survey revealed that only 24 % of the German ENT-hospitals performed sialendoscopy. In 2016 the survey was repeated to reevaluate the actual ranking of sialendoscopy in Germany.

Material Und Methods: Again, the same questionnaire as in 2009 was sent to all German ENT-hospitals. Read More

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December 2018
1 Read

[Transcranial direct current stimulation (tDCS) for obsessive-compulsive disorder: A new treatment option?]

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum der Universität München.

More than 40 % of patients with obsessive-compulsive disorder (OCD) do not respond to established treatments despite advances in psychopharmacology and psychotherapy. Since a couple of years, non-invasive brain stimulation techniques gain importance in the treatment of psychiatric disorders. Transcranial direct current stimulation (tDCS) uses weak constant direct current to modulate neuronal activation and changes the function of neuronal networks. Read More

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December 2018
1 Read

[Coercion and aggression in psychiatry: the individual psychological dimension of aggressive and coercive acts by therapists].

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Klinik für Psychiatrie, Psychotherapie und Präventivmedizin, LWL-Universitätsklinikum der Ruhr-Universität Bochum.

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December 2018

Psychiatric comorbidy in Ullrich-Turner syndrome.

Fortschr Neurol Psychiatr 2018 Dec 11. Epub 2018 Dec 11.

Ruhr-Universität Bochum, Psychiatrie.

Objective: Ullrich-Turner Syndrome (UTS; Turner Syndrome (TS)) is a X-chromosomal disorder, which is characterized by a variety and heterogenous clinical conditions. Although it is not typically associated with neuropsychiatric disorders, several case reports describe concomitant TS and neuropsychiatric abnormalities that may represent a pathogenetic link.

Methods: Based on the case representation of woman with TS and co-occurrent schizoaffective disorder we discuss possible relationships and current literature. Read More

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December 2018
2 Reads

[Acute Motor Failure of the N. Peroneus Profundus Caused by a Cystic Tibiofibular Joint].

Z Orthop Unfall 2018 Dec 11. Epub 2018 Dec 11.

Orthopädie und Traumatologie, Bürgerspital Solothurn, Solothurn, Schweiz.

A ganglion cyst is rarely the cause of peripheral nerve compression. In the lower extremity, it is important to distinguish clinically the symptoms from a radiculopathy. In the literature, neural damage of the peroneal nerve due to a ganglion cyst has been described. Read More

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December 2018

Palliative Care in Patients with Hematological Malignancies.

Authors:
Karin Oechsle

Oncol Res Treat 2018 Dec 12;42(1-2). Epub 2018 Dec 12.

Patients with hematologic malignancies (HM) nowadays rarely receive palliative or hospice care, and studies on potential effects of integrated palliative care are rare. This narrative review provides a comprehensive overview on their current end-of-life care, first data on integrated specialist palliative care (SPC) and potential barriers. Symptom burden and distress in patients with HM seem to be comparable to other cancer patients, but their performance status and specific symptoms are even worse. Read More

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December 2018

Infants who die in shared sleeping situations differ from those who die while sleeping alone.

Acta Paediatr 2018 Dec 10. Epub 2018 Dec 10.

Discipline of Anatomy and Pathology, Adelaide Medical School, The University of Adelaide, Adelaide, Australia.

Aim: To determine whether there are differences between infants who are sharing a sleeping surface with others, compared to those who die alone.

Methods: A literature review was undertaken of pubmed and google scholar databases using search terms: sudden infant death syndrome, SIDS, cosleeping and overlaying.

Results: Statistically significant differences were found between the two groups in the sex ratios, and in staining of brain sections for β-amyloid precursor protein (β-APP), glial fibrillary acidic protein (GFAP) and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling (TUNEL). Read More

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December 2018

Vagales Paragangliom mit anatomischer Rarität der Blutversorgung.

Laryngorhinootologie 2018 Dec 10;97(12):871-872. Epub 2018 Dec 10.

Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Uniklinik Köln.

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December 2018

Rückkehr in das Erwerbsleben nach kurativer Therapie von Kopf-Hals-Karzinomen.

Laryngorhinootologie 2018 Dec 10;97(12):838-845. Epub 2018 Dec 10.

Universitätsklinikum Leipzig AöR Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde.

Objective: Reintegration of cancer patients into occupational life is an important social and economic factor. Data for the "return to work" in Head and Neck Cancer (HNC) patients are sparse, especially compared with other tumor entities.

Material And Methods: In a selective literature research, original articles dealing with the theme complex "return to work in patients with HNC", between 1997 and 2018 were included and analyzed. Read More

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December 2018

[Is it Reasonable to Establish an Independently Managed Obstetric Unit in a Small Hospital and Does it Result in Measurable Changes in Quality of Maternity Care?]

Z Geburtshilfe Neonatol 2018 Dec 7. Epub 2018 Dec 7.

Geschäftsstelle Qualitätssicherung Hessen, GQH, Eschborn.

Introduction: An independently managed, specialty obstetric unit in a small hospital setting resulted in measurable changes in quality of maternity care.

Material And Methods: We present obstetric data from a level I (basic care) hospital in Frankfurt, Germany. We compare data from the mandatory state register collected in 2013, when the obstetric unit was under single management with the gynaecology department, with data collected in 2016 after the establishment of independent obstetric unit and a specialised service. Read More

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December 2018

[Prehospital Emergency Management of Pregnant Women - Obstetric Emergencies Series, Part 1].

Z Geburtshilfe Neonatol 2018 Dec 10;222(6):237-244. Epub 2018 Dec 10.

Institut für Rettungs- und Notfallmedizin, Universitätsklinikum Schleswig Holstein.

Maternal emergencies during pregnancy are characterized by a concomitant threat to 2 patients. These emergencies can occur during or even before a hospital stay. Due to the rarity of the latter cases, sustainable methods of knowledge transfer should be implemented so emergency teams have sufficient obstetrical information to provide emergency care during pregnancy. Read More

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December 2018

[Registry Research Funding of the German Society of Plastic, Reconstructive and Aesthetic Surgeons (DGPRÄC) and Research Funding Report 2017/2018].

Handchir Mikrochir Plast Chir 2018 Dec 10. Epub 2018 Dec 10.

Klinik und Poliklinik für Plastische, Hand- und Wiederherstellungschirurgie, Medizinische Hochschule Hannover.

Introduction: This report serves to publicize the research of academic institutions for Plastic Surgery within our society DGPRÄC in 2017/2018 and sequels the funding report of 2015/2016. Applications to public, non-public, or industrial funding organizations were evaluated. At the same time, this paper analyses the number of approved DFG applications in Plastic, Thoracic and Vascular Surgery in the GEPRIS system. Read More

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December 2018

Hyperplastic polyps and nonadvanced adenomas, but not advanced polypoid lesions, are detected more frequently in the presence of colonic diverticula during screening colonoscopies.

Z Gastroenterol 2018 Dec 10;56(12):1475-1480. Epub 2018 Dec 10.

Department of Gastroenterology and Hepatology, University Hospital Cologne, Germany.

Hintergrund:  Die bisher veröffentlichte Studienlage zur Assoziation von Kolondivertikeln und kolorektalen Polypen einschließlich des kolorektalen Karzinoms (KRK) ist konträr. Ziel der Studie war es, die Assoziation für sämtliche relevanten histologischen Polypensubtypen, d. h. Read More

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December 2018

[Crazy Paving Pattern of the Lung].

Pneumologie 2018 Dec 7. Epub 2018 Dec 7.

Abteilung für Pneumologie, Fachklinik für Lungenerkrankungen Donaustauf, Donaustauf.

Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease. PAP results from impaired surfactant clearance. In adults, autoimmune pulmonary alveolar proteinosis is present in 90 - 95 % of the cases. Read More

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December 2018

Nej – barn med typ 1-diabetes lever inte i ständig livsfara.

Lakartidningen 2018 Dec 7;115. Epub 2018 Dec 7.

No - children with type 1 diabetes do not live in constant danger Proper information about Type 1 diabetes is required. This applies, among other things, to the risk for type 1 diabetes children to die in hypoglycaemia, which is extremely small. Read More

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December 2018

Long-Term Culture of Mouse Fetal Hepatic Stem/Progenitor Cells.

Methods Mol Biol 2019 ;1905:3-8

Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan.

Mouse fetal liver includes abundant hepatic stem/progenitor cells (HSPCs). Easy expansion with passage of HSPCs is necessary to obtain steady data. However, it is often difficult to enrich only HSPCs, and HSPCs can die when usual trypsin is used for replating. Read More

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January 2019

[Therapy-resistant coccygodynia should no longer be considered a myth : The surgical approach].

Orthopade 2018 Dec 7. Epub 2018 Dec 7.

Orthopädische Klinik für die Universität Regensburg, Asklepios Klinikum Bad Abbach, Kaiser-Karl-V-Allee 3, 93077, Bad Abbach, Deutschland.

Background: Coccygodynia is still often considered a mystery, and many patients are not taken seriously with their problems and pain.

Case: A 51-year-old thin lady presented at our clinic with lifelong, persistent low back pain. The clinical examination indicated suspicion of coccygodynia. Read More

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December 2018

Trends in the use of seat belts and mobile phones and their seasonal variations in Florence (2005-2015).

PLoS One 2018 11;13(12):e0208489. Epub 2018 Dec 11.

Department of Health Science, University of Florence, Florence, Italy.

Introduction: About 1.25 million people worldwide die every year because of road accidents. Risk is higher when drivers use mobile phones, whereas seat belts help to prevent crash-related injury. Read More

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December 2018

Health care-associated infections - an overview.

Infect Drug Resist 2018 15;11:2321-2333. Epub 2018 Nov 15.

Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kem Sungai Besi, 57000 Kuala Lumpur, Malaysia,

Health care-associated infections (HCAIs) are infections that occur while receiving health care, developed in a hospital or other health care facility that first appear 48 hours or more after hospital admission, or within 30 days after having received health care. Multiple studies indicate that the common types of adverse events affecting hospitalized patients are adverse drug events, HCAIs, and surgical complications. The US Center for Disease Control and Prevention identifies that nearly 1. Read More

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November 2018

Symptomatic HIV-Infected Patients Have Poorer Outcomes Following Emergency General Surgery: A Study of the Nationwide Inpatient Sample.

J Trauma Acute Care Surg 2018 Dec 5. Epub 2018 Dec 5.

Department of Surgery, Section of General Surgery, Trauma, and Surgical Critical Care, Yale School of Medicine, New Haven, CT USA.

Background: The impact of HIV infection on outcomes following common emergency general surgery procedures has not been evaluated since the widespread introduction of highly-active antiretroviral therapy (HAART).

Methods: A retrospective cohort study was conducted using the Nationwide Inpatient Sample. Records of patients who underwent laparoscopic or open appendectomy, cholecystectomy, or colon resection after emergency admission from 2004-2011 were obtained. Read More

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December 2018

Amyotrophic lateral sclerosis as a synaptopathy.

Neural Regen Res 2019 Feb;14(2):189-192

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA; School of Biomedical Sciences, The University of Queensland, St. Lucia, Australia.

The synapse is an incredibly specialized structure that allows for the coordinated communication of information from one neuron to another. When assembled into circuits, steady streams of excitatory and inhibitory synaptic activity shape neural outputs. At the organismal level, ensembles of neural networks underlie behavior, emotion and memory. Read More

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February 2019

Enterovirus and parechovirus meningitis in infants younger than 90 days old in the UK and Republic of Ireland: a British Paediatric Surveillance Unit study.

Arch Dis Child 2018 Dec 8. Epub 2018 Dec 8.

Paediatric Infectious Diseases Research Group, St George's University of London, London, UK.

Objectives: This study aimed to prospectively collect detailed clinical information for all enterovirus (EV) and human parechovirus (HPeV) meningitis cases in infants aged <90 days in the UK and Ireland.

Participants, Design And Setting: Prospective, active national surveillance during July 2014 to July 2015 through the British Paediatric Surveillance Unit. Reporting paediatricians completed questionnaires requesting information on clinical presentation, investigations, management and outcomes at hospital discharge and after 12 months. Read More

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December 2018

Operationalising a conceptual framework for a contiguous hospitalisation episode to study associations between surgical timing and death after first hip fracture: a Canadian observational study.

BMJ Open 2018 Dec 6;8(12):e020372. Epub 2018 Dec 6.

Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

Objective: We describe steps to operationalise a published conceptual framework for a contiguous hospitalisation episode using acute care hospital discharge abstracts. We then quantified the degree of bias induced by a first abstract episode, which does not account for hospital transfers.

Design: Retrospective observational study. Read More

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December 2018

Probing the impact of HPMC viscosity grade and proportion on the physical properties of co-freeze-dried mannitol-HPMC tableting excipients using multivariate analysis methods.

Int J Pharm 2018 Dec 6. Epub 2018 Dec 6.

GEA-NUS Pharmaceutical Processing Research Laboratory, Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore. Electronic address:

This study investigated the impact of hydroxypropyl methylcellulose (HPMC) viscosity grade, HPMC proportion and particle size fraction on the physical properties of the freeze-dried mannitol-HPMC excipients produced, using multivariate analysis methods. Solutions containing 20 %, w/w mannitol-HPMC were freeze-dried and milled to obtain excipients of size fractions 125-355 μm and 355-710 μm to understand the impact of the formulation variables on the molecular, particle and bulk properties of the excipients. Results showed that the freeze-dried mannitol-HPMC excipients were mainly differentiated by 3 overarching properties, in the order of their contribution to the variation in the principal component analysis (PCA) model: (i) freeze-dried cake strength and bulk fill-related properties, (ii) compression behaviour-related properties, and (iii) flow-related properties. Read More

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December 2018

Disentangling the evolution of MEDLINE bibliographic database: A complex network perspective.

J Biomed Inform 2018 Dec 6. Epub 2018 Dec 6.

Institute of Biostatistics and Medical Informatics, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, SI-1000 Ljubljana, Slovenia. Electronic address:

Scientific knowledge constitutes a complex system that has recently been the topic of in-depth analysis. Empirical evidence reveals that little is known about the dynamic aspects of human knowledge. Precise dissection of the expansion of scientific knowledge could help us to better understand the evolutionary dynamics of science. Read More

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December 2018

Calcium signalling: A common target in neurological disorders and neurogenesis.

Semin Cell Dev Biol 2018 Dec 5. Epub 2018 Dec 5.

Department of Biochemistry, IQ, University of Sao Paulo, Sao Paulo, Brazil. Electronic address:

Calcium is the ubiquitous second messenger used by any living cell. The fine-tuning of intracellular free calcium [(Ca)] homeostasis and signalling pathways is crucial for the maintenance of the healthy organism. Many alterations in the homeostasis can be compensated by robust mechanisms; however, cells that already present some debility in those mechanisms, or that are over stimulated cannot compensate the stress and die. Read More

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December 2018

Myelodysplastic syndromes and acute myeloid leukemias in the elderly.

Eur J Intern Med 2018 Dec;58:28-32

Department of Medical Oncology, Inselspital, University Hospital and University of Bern, Bern, Switzerland. Electronic address:

Most patients above 60 years with acute myeloid leukemia (AML) will die from their disease. Nevertheless, the treatment concepts in elderly patients with myelodysplastic syndromes (MDS) and AML are rapidly evolving. A number of recent reports have identified better survival rates with intensive induction chemotherapy for patients up to 80 years, with the exception of patients with unfavorable genomic risk abnormalities or with major co-morbidities. Read More

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December 2018

Hybrid Rare-Earth(III)/Bismuth(III) Clusters Assembled with Phosphonates.

Inorg Chem 2018 Dec 7. Epub 2018 Dec 7.

State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering , Huazhong University of Science and Technology , Wuhan 430074 , China.

tert-Butylphosphonic acid and rare-earth precursors are employed to construct four trinuclear rare-earth phosphonate clusters, RE( BuPO)(hfac)(CHOH)]·2CHOH (RE = Eu, Y, Pr, and Sm; hfac = hexafluoroacetylacetonate), which are composed of three RE ions alternately bridged by two phosphonates. With the introduction of bismuth oxido diketonate, [BiO(hfac)], three different types of rare-earth/bismuth phosphonate clusters, BiRE (RE = Pr and Sm), BiEu, and BiY, are successfully obtained via variation of the reaction conditions, and they are the first reported examples of bismuth-oxo clusters encapsulated by cyclic rare-earth-oxo or rare-earth/bismuth-oxo phosphonate clusters, respectively. These clusters show obvious absorption in the UV region, and the Eu-containing clusters exhibit bright-red fluorescence. Read More

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December 2018

Perineale Urethrektomie beim Mann.

Aktuelle Urol 2018 Dec 6;49(6):530-541. Epub 2018 Dec 6.

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December 2018
3 Reads