6,161 results match your criteria Diaphragmatic Paralysis

Histomorphology of Amyotrophic Lateral Sclerosis: An Autopsy Case Report.

Cureus 2021 May 13;13(5):e14999. Epub 2021 May 13.

General and Clinical Pathology/Forensic Medicine and Deontology, Medical University of Varna, Varna, BGR.

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting predominantly the motor neurons of the anterior horns of the spinal cord. The condition, in most cases, starts with lower limb muscle weakness that steadily progresses and affects all muscle groups of the body. This in time leads to severe muscle atrophy and muscle paralysis, with respiratory muscle affection leading to respiratory failure. Read More

View Article and Full-Text PDF

Surgical clipping and endovascular embolization for senile patients with posterior communicating artery aneurysms complicated with oculomotor nerve palsy.

Am J Transl Res 2021 15;13(5):5679-5684. Epub 2021 May 15.

Department of Neurosurgery, Wuhan Puren Hospital, Wuhan University of Science and Technology Wuhan, China.

Objective: To explore the clinical effect of the surgical clipping and endovascular embolization for senile patients with posterior communicating artery aneurysms (PComA) complicated with oculomotor nerve palsy (ONP) and their neurological recovery.

Methods: A total of 96 senile patients with PComA complicated with ONP admitted to our hospital from May 2018 to May 2019 were selected and assigned into the experimental group and the control group according to the randomization method, with 48 cases in each group. The patients in the control group underwent surgical clipping, whereas the patients in the experimental group received the endovascular embolization. Read More

View Article and Full-Text PDF

The Role of Regional Anesthesia During the SARS-CoV2 Pandemic: Appraisal of Clinical, Pharmacological and Organizational Aspects.

Front Pharmacol 2021 4;12:574091. Epub 2021 Jun 4.

Department of Anesthesia, Critical Care and Pain Medicine, Niguarda Ca' Granda Hospital, Milan, Italy.

The severe acute respiratory syndrome coronavirus SARS-CoV2 is spreading over millions of people worldwide, leading to thousands of deaths, even among the healthcare providers. Italy has registered the deaths of 337 physicians and more than 200 nurses as of March 14, 2021. Anesthesiologists are at higher risk as they are the care providers in both ICU and operating rooms. Read More

View Article and Full-Text PDF

Unilateral diaphragm paralysis with COVID-19 infection.

BMJ Case Rep 2021 Jun 17;14(6). Epub 2021 Jun 17.

Department of Respiratory Medicine, Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, UK.

Neurological complications are well described in SARS-CoV-2, but for the first time we report a case of unilateral diaphragm paralysis occurring early in mechanical ventilation for respiratory failure due to such an infection. The patient subsequently required tracheostomy and ventilator support for 37 days, and had increased breathlessness and an elevated diaphragm at clinic review 9 months later. Dynamic chest radiography demonstrated persistent diaphragm paralysis with an accompanying postural change in lung volumes, and he subsequently underwent surgical plication. Read More

View Article and Full-Text PDF

Bilateral diaphragmatic paralysis and Lyme neuroborreliosis. Ten years of follow-up.

Medicina (B Aires) 2021 ;81(3):474-477

Instituto de Investigaciones Médicas Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina. E-mail:

Borrelia burgdorferi infection (Lyme disease) is one of the few identifiable causes of neuralgic amyotrophy. Bilateral diaphragmatic paralysis is considered rare in borreliosis, and the pattern of long-term recovery of diaphragm function is also uncertain. Transdiaphragmatic pressure is the gold standard for diagnosis of bilateral diaphragmatic paralysis, a study that has been reported on few occasions. Read More

View Article and Full-Text PDF

Osmotic Demyelination Syndrome: Clinical, Neuroimaging Characteristics, and Outcomes in a Series of 18 Cases.

Biomed Res Int 2021 28;2021:9944632. Epub 2021 May 28.

Department of Hematopathology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000 Zhejiang, China.

Objective: To investigate the etiology, clinical as well as neuroimaging characteristics, and outcomes after proper treatment in a series of 18 patients with osmotic demyelination syndrome.

Methods: Medical records, including video records, of 18 patients with osmotic demyelination syndrome were retrospectively examined. Demographic and clinical information, imaging results, plans of management, and outcomes during the follow-up period were collected and analyzed. Read More

View Article and Full-Text PDF

Guillain-Barre Syndrome following SARS-COVID-19 Infection: A Case Report from India.

Case Rep Infect Dis 2021 27;2021:4676659. Epub 2021 May 27.

Department of Medicine, All India Institute of Medical Sciences, Bhopal, India.

Severe acute respiratory syndrome coronavirus 2 (SARS-COVID-19) is a novel coronavirus that started in Wuhan City in China in December 2019. It can cause acute respiratory infection. Guillain-Barre syndrome (GBS) is an autoimmune disease characterized by rapidly progressing ascending paralysis that is triggered by an infection or immune stimulation which produces an abnormal immune response that targets peripheral nerves. Read More

View Article and Full-Text PDF

Comparison of fixed dose versus train-of-four titration of cisatracurium in acute respiratory distress syndrome.

J Crit Care 2021 May 25;65:86-90. Epub 2021 May 25.

University of Kentucky HealthCare, Department of Pharmacy Services, United States of America; University of Kentucky College of Pharmacy, Department of Pharmacy Practice and Science, United States of America. Electronic address:

Purpose: To compare the ventilatory and clinical outcomes associated with a fixed-dose cisatracurium infusion versus a titrated infusion strategy in patients with Acute Respiratory Distress Syndrome (ARDS).

Materials And Methods: Single-center, retrospective, cohort study in a medical ICU of a tertiary care academic medical center. Adult patients ≥18 years old with a continuous infusion of cisatracurium for ≥12 h for treatment of ARDS were included. Read More

View Article and Full-Text PDF

[Application progress of ultrasound monitoring of diaphragm function in clinic].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):638-640

Department of Anesthesiology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China.

In recent years, point of care ultrasound (POCUS) has developed rapidly in the fields of anesthesia and critical care. POCUS is widely used in clinic to monitor the function of human tissues and organs such as the heart, lungs, and diaphragm due to its visual, non-invasive, portable, and repeatable characters at the bedside. Diaphragm is an important structure to maintain respiratory function. Read More

View Article and Full-Text PDF

(L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different   and Systems.

Biology (Basel) 2021 May 18;10(5). Epub 2021 May 18.

Facultad de Ciencias de la Salud, Universidad San Jorge, Villanueva de Gállego, 50830 Zaragoza, Spain.

In traditional medicine, (L.) DC or rock tea (RT) has been mainly used to treat digestive and respiratory pathologies but also as an antimicrobial or an antidepressant herbal remedy. An ethanolic extract of RT has been demonstrated to have antioxidant and anti-inflammatory effects, which may be explained by its phytochemical profile, rich in polyphenols and pigments. Read More

View Article and Full-Text PDF

Fulminant Guillain-Barré Syndrome Post Hemorrhagic Stroke: Two Case Reports.

Neurol Int 2021 May 6;13(2):190-194. Epub 2021 May 6.

Neuroscience Centre, Neurology Department, King Fahad Specialist Hospital-Dammam, Dammam 31444, Saudi Arabia.

Guillain-Barré syndrome (GBS) is an acute, immune-mediated inflammatory peripheral polyneuropathy characterized by ascending paralysis. Most GBS cases follow gastrointestinal or chest infections. Some patients have been reported either following or concomitant with head trauma, neurosurgical procedures, and rarely hemorrhagic stroke. Read More

View Article and Full-Text PDF

Hemidiaphragmatic paralysis related to extravasation of parenteral solution in very low birthweight neonates.

BMJ Case Rep 2021 May 27;14(5). Epub 2021 May 27.

Neonatal Inetnsive Care, University of Alberta, Edmonton, Alberta, Canada

Central venous catheter (CVC) placement is common in the care of very low birthweight (VLBW) preterm neonates. Although it is generally considered to be safe, CVC placement is associated with complications, including extravasation that may lead to significant morbidity and mortality. We report the clinical course of an extremely preterm neonate born at 27 weeks gestation, and another 5 VLBW preterm neonates reported in the literature with hemidiaphragmatic paralysis related to extravasation of parenteral solution from CVC placement. Read More

View Article and Full-Text PDF

SARS-CoV-2-associated Guillain-Barré syndrome is a para-infectious disease.

QJM 2021 May 27. Epub 2021 May 27.

Department of Respiratory and Critical Care Medicine, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, People's Republic of China.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been linked to the Guillain-Barré syndrome (GBS). The objective of the present study is to identify specific clinical features of cases of GBS reported in the literature associated with SARS-CoV-2 infection. We searched Pubmed, and included single case reports and case series with full text in English, reporting original data of patients with GBS and a confirmed recent SARS-CoV-2 infection. Read More

View Article and Full-Text PDF

[A Case of Multiple Brain Tumors Successfully Diagnosed with Liquid Biopsy and Treated with Osimertinib].

Gan To Kagaku Ryoho 2021 May;48(5):677-679

Division of Respiratory Medicine, Dept. of Internal Medicine, Kobe University Graduate School of Medicine.

A seventy‒year‒old man complaining of left arm weakness and gait disturbance was diagnosed with multiple tumors and severe edema in the brain as well as right lung mass lesion, suggesting brain metastases. He started whole brain radiation therapy but had to discontinue it since his neurological symptoms were worsened including paralysis, aphasia, and coma. These symptoms made it difficult to perform tumor biopsy for cancer diagnosis as well as oncogene mutations. Read More

View Article and Full-Text PDF

Acute flaccid paralysis and neurogenic respiratory failure associated with enterovirus D68 infection in children: Report of two cases.

World J Clin Cases 2021 May;9(14):3327-3333

Department of Hyperbaric Oxygen, The Sixth Medical Center of PLA General Hospital, Beijing 100048, China.

Background: Acute flaccid paralysis (AFP) and neurogenic respiratory failure rarely occur in children. At the end of 2018, some children with such symptoms were admitted to our hospital. In this study, we aimed to assess two children with AFP and neurogenic respiratory failure associated with enterovirus D68 (EV-D68). Read More

View Article and Full-Text PDF

Outcome analysis of a conservative approach to diaphragmatic paralysis following congenital cardiac surgery in neonates and infants: a bicentric retrospective study.

Interact Cardiovasc Thorac Surg 2021 May 17. Epub 2021 May 17.

Department of Pediatric Cardiology and Congenital Cardiac Surgery, University Hospital, Nantes, France.


Objectives: Diaphragmatic paralysis following congenital cardiac surgery is associated with significant morbidity and mortality. Spontaneous recovery of diaphragmatic function has been described, contrasting with centres providing early diaphragmatic plication. We aimed to describe the outcomes of a conservative approach, as well as to identify factors associated with a failure of the strategy. Read More

View Article and Full-Text PDF

Genetic analysis of Enterovirus D68 associated with pneumonia in children from South India.

J Med Microbiol 2021 May;70(5)

Present address: Consultant at World Health Organisation- country office for Nepal, Nepal, India.

EV-D68 is an emerging enterovirus infection associated with severe acute respiratory illness (SARI), acute flaccid myelitis (AFM) and acute flaccid paralysis (AFP). While EV-D68 outbreaks and sporadic cases are reported globally, a single case has been reported from India. The present study aims to investigate the molecular epidemiology and clinical characteristics of EV-D68-associated SARI cases from South India. Read More

View Article and Full-Text PDF

Intensive Care and Treatment of Severe Guillain-Barré Syndrome.

Front Pharmacol 2021 27;12:608130. Epub 2021 Apr 27.

Department of Life Sciences, National Natural Science Foundation of China, Beijing, China.

Guillain-Barré syndrome (GBS) is an acute polyneuropathy mostly characterized by acute flaccid paralysis with or without sensory/autonomous nerve dysfunction. Current immuno therapies including intravenous immunoglobulin (IVIg), plasma exchange (PE), and newly developed biological drugs benefit patients by alleviating hyperreactive immune responses. Up to 30% of patients develop respiratory failure during hospitalization and require mechanical ventilation and intensive care. Read More

View Article and Full-Text PDF

A Comparison of Anesthetic Quality Between Interscalene Block and Superior Trunk Block for Arthroscopic Shoulder Surgery: A Randomized Controlled Trial.

Pain Physician 2021 May;24(3):235-242

Department of Anesthesiology and Pain Medicine, Anam Hospital, Korea University College of Medicine, Seoul.

Background: Interscalene block is the most commonly used nerve block for shoulder surgery, and superior trunk block has been investigated as a phrenic-sparing alternative. This randomized controlled trial compared ultrasound-guided interscalene block and superior trunk block as anesthesia for arthroscopic shoulder surgery.

Objectives: Our aims were to determine the superiority of anesthesia quality and compare the risk of hemidiaphragmatic paralysis between these 2 blocks. Read More

View Article and Full-Text PDF

Impaired neuromuscular function by conjoint actions of organophosphorus insecticide metabolites omethoate and cyclohexanol with implications for treatment of respiratory failure.

Clin Toxicol (Phila) 2021 May 14:1-20. Epub 2021 May 14.

Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK.

Background: Ingestion of agricultural organophosphorus insecticides is a significant cause of death in rural Asia. Patients often show acute respiratory failure and/or delayed, unexplained signs of neuromuscular paralysis, sometimes diagnosed as "Intermediate Syndrome". We tested the hypothesis that omethoate and cyclohexanol, circulating metabolites of one agricultural formulation, cause muscle weakness and paralysis. Read More

View Article and Full-Text PDF

Noteworthy Neurological Manifestations Associated With COVID-19 Infection.

Adam C Kaplan

Cureus 2021 Apr 9;13(4):e14391. Epub 2021 Apr 9.

Internal Medicine, St. Francis Medical Center, Trenton, USA.

March 11, 2020 marked the start of the coronavirus disease 2019 (COVID-19) pandemic. COVID-19, caused by severe acute respiratory syndrome coronavirus 2, was being reported as a severe respiratory illness. However, since the recognition of this novel virus, there has been a constant realization that it may present or manifest in a multitude of ways. Read More

View Article and Full-Text PDF

Infant botulism: an underestimated threat.

Infect Dis (Lond) 2021 May 8:1-14. Epub 2021 May 8.

Pediatric Clinic, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

Infant botulism (IB) is defined as a potentially life-threatening neuroparalytic disorder affecting children younger than 12 months. It is caused by ingestion of food or dust contaminated by spores, which germinate in the infant's large bowel and produce botulinum neurotoxin. Although the real impact of IB is likely underestimated worldwide, the USA has the highest number of cases. Read More

View Article and Full-Text PDF

Clinical Guidelines for Diagnosis and Treatment of Botulism, 2021.

MMWR Recomm Rep 2021 05 7;70(2):1-30. Epub 2021 May 7.

Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, CDC.

Botulism is a rare, neurotoxin-mediated, life-threatening disease characterized by flaccid descending paralysis that begins with cranial nerve palsies and might progress to extremity weakness and respiratory failure. Botulinum neurotoxin, which inhibits acetylcholine release at the neuromuscular junction, is produced by the anaerobic, gram-positive bacterium Clostridium botulinum and, rarely, by related species (C. baratii and C. Read More

View Article and Full-Text PDF

Management of patients with bilateral recurrent laryngeal nerve paralysis following esophagectomy.

Thorac Cancer 2021 Jun 6;12(12):1851-1856. Epub 2021 May 6.

Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Background: Recurrent laryngeal nerve paralysis (RLNP) is a common complication after esophagectomy which can cause severe pulmonary complications. However, bilateral RLNP has been rarely reported in esophagectomy patients. The objective of our study is to investigate the clinical significance of patients who had bilateral RLNP following esophagectomy. Read More

View Article and Full-Text PDF

Laryngeal function in normal dogs administered isoflurane following partial clearance of alfaxalone or propofol.

Vet Anaesth Analg 2021 Apr 1. Epub 2021 Apr 1.

Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.

Objective: To assess laryngeal function in normal dogs administered isoflurane following partial clearance of alfaxalone or propofol.

Study Design: Randomized experimental crossover study.

Animals: A group of 12 purpose-bred, male Beagle dogs. Read More

View Article and Full-Text PDF

Immune Profile in Patients With COVID-19: Lymphocytes Exhaustion Markers in Relationship to Clinical Outcome.

Front Cell Infect Microbiol 2021 15;11:646688. Epub 2021 Apr 15.

Centre for Primary Immunodeficiencies, Clinic of Pneumology and Phthisiology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin University Hospital, Martin, Slovakia.

The velocity of the COVID-19 pandemic spread and the variable severity of the disease course has forced scientists to search for potential predictors of the disease outcome. We examined various immune parameters including the markers of immune cells exhaustion and activation in 21 patients with COVID-19 disease hospitalised in our hospital during the first wave of the COVID-19 pandemic in Slovakia. The results showed significant progressive lymphopenia and depletion of lymphocyte subsets (CD3, CD4, CD8 and CD19) in correlation to the disease severity. Read More

View Article and Full-Text PDF

A cluster of tetrodotoxin poisoning in Oman.

Clin Toxicol (Phila) 2021 Apr 29:1-5. Epub 2021 Apr 29.

Emory University School of Medicine, Atlanta, GA, USA.

Introduction: Tetrodotoxin (TTX) is a potent sodium channel blocker, with significant neurotoxicity, found in marine animals like pufferfish and blue-ringed octopus. The severity of toxicity depends on the amount of toxin ingested and the outcome depends on the time-lapse to appropriate medical care.

Cases Report: We report five patients who presented with tetrodotoxin poisoning after consuming fried internal organs of local pufferfish from the coast of Oman. Read More

View Article and Full-Text PDF

Clinical predictors for mechanical ventilation and prognosis in patients with Guillian-Barre syndrome: a 10-year experience.

Neurol Sci 2021 Apr 20. Epub 2021 Apr 20.

Neurology Department, Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates.

Introduction: Guillain-Barré syndrome (GBS) is a common cause of flaccid paralysis. Up to a third of cases result in respiratory failure requiring mechanical ventilation.

Aim: We aim to study the possible predictors of respiratory compromise requiring mechanical ventilation in cases of GBS as well as their clinical outcome in the UAE population. Read More

View Article and Full-Text PDF

Diaphragmatic paralysis, respiratory function, and postoperative pain after interscalene brachial plexus block with a reduced dose of 10 ml levobupivacaine 0.25% versus a 20 ml dose in patients undergoing arthroscopic shoulder surgery: study protocol for the randomized controlled double-blind REDOLEV study.

Trials 2021 Apr 19;22(1):287. Epub 2021 Apr 19.

Department of Pneumology, Miguel Servet University Hospital, Zaragoza, Spain.

Background: Arthroscopic shoulder surgery causes severe postoperative pain. An interscalene brachial plexus block provides adequate analgesia, but unintended spread of the local anesthetic administered may result in a phrenic nerve block, usually associated with a nonnegligible incidence of acute hemidiaphragmatic paralysis. The main purpose of this trial will be to analyze the incidence of hemidiaphragmatic paralysis ensuing after interscalene brachial plexus block in patients undergoing arthroscopic shoulder surgery administered a standard volume (20 ml) vs. Read More

View Article and Full-Text PDF