5,632 results match your criteria Diaphragmatic Paralysis


Dysautonomia and hyponatraemia as harbingers of Guillain-Barre syndrome.

BMJ Case Rep 2019 Apr 15;12(4). Epub 2019 Apr 15.

Department of Critical Care, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India.

A 56-year-old woman with a medical history of hypertension presented to our hospital with back pain, abdominal pain, vomiting and elevated blood pressure. The laboratory parameters including evaluation for secondary hypertension were within normal ranges at the time of presentation. During her hospitalisation, fluctuations in her blood pressure and pulse were observed which were attributed to autonomic disturbances, the cause of which was unknown. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22692
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http://dx.doi.org/10.1136/bcr-2018-226925DOI Listing
April 2019
1 Read

Flavin adenine dinucleotide synthase deficiency due to FLAD1 mutation presenting as multiple acyl-CoA dehydrogenation deficiency-like disease: A case report.

Brain Dev 2019 Apr 11. Epub 2019 Apr 11.

Department of Pediatrics, Shimane University, Faculty of Medicine, Izumo, Shimane, Japan.

Multiple acyl-CoA dehydrogenase deficiency (MADD), also known as glutaric acidemia type II, is classically caused by a congenital defect in electron transfer flavoprotein (ETF) or ETF dehydrogenase (ETFDH). Flavin adenine dinucleotide synthase (FADS) deficiency caused by mutations in FLAD1 was recently reported as a novel riboflavin metabolism disorder resembling MADD. Here, we describe a Japanese boy with FADS deficiency due to a novel mutation (p. Read More

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http://dx.doi.org/10.1016/j.braindev.2019.04.002DOI Listing

Non-invasive fungal sinusitis resulting in multiple cranial nerve neuropathies.

BMJ Case Rep 2019 Apr 8;12(4). Epub 2019 Apr 8.

Department of Ear, Nose & Throat Surgery, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.

A 33-year-old man presented to the emergency department with a right-sided facial paralysis and maxillary division (V2, trigeminal nerve) paraesthesia. He had been suffering with upper respiratory tract symptoms in the preceding 2 months, including rhinorrhoea, fever and headache. The patient was otherwise fit and immunocompetent. Read More

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http://dx.doi.org/10.1136/bcr-2018-229094DOI Listing
April 2019
1 Read

The Feasibility of Using the Posterior Auricular Branch of the Facial Nerve as a Donor for Facial Nerve Reanimation Procedures: A Cadaveric Study.

J Oral Maxillofac Surg 2019 Mar 13. Epub 2019 Mar 13.

Chief Scientific Officer, Seattle Science Foundation, Seattle, WA; Professor, Department of Anatomical Sciences, St George's University, Grenada, West Indies.

Purpose: Facial nerve paralysis can result in critical complications, including those to the visual, respiratory, and digestive systems. The facial nerve has been reanimated using various nerves, but the posterior auricular nerve (PAN) branching off the facial nerve has not been explored for this purpose.

Materials And Methods: Ten sides from 6 fresh-frozen adult cadavers were used for dissection of the PAN to explore its potential as a donor for facial nerve reanimation. Read More

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http://dx.doi.org/10.1016/j.joms.2019.02.043DOI Listing
March 2019
1 Read

Identifying and treating intrinsic PEEP in infants with severe bronchopulmonary dysplasia.

Pediatr Pulmonol 2019 Apr 4. Epub 2019 Apr 4.

Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Rationale: Infants with severe bronchopulmonary dysplasia (sBPD) and airway obstruction may develop dynamic hyperinflation and intrinsic positive end-expiratory pressure (PEEP ), which impairs patient/ventilator synchrony.

Objectives: To determine if PEEP is present in infants with sBPD during spontaneous breathing and if adjusting ventilator PEEP improves patient/ventilator synchrony and comfort.

Methods: Interventional study in infants with sBPD. Read More

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http://dx.doi.org/10.1002/ppul.24328DOI Listing
April 2019
1 Read

New insights into the phylogeographic distribution of the 3FTx/PLA venom dichotomy across genus Micrurus in South America.

J Proteomics 2019 Apr 1;200:90-101. Epub 2019 Apr 1.

Evolutionary and Translational Venomics Laboratory, CSIC, Valencia, Spain. Electronic address:

Micrurus is a monophyletic genus of venomous coral snakes of the family Elapidae. The ~80 recognized species within this genus are endemic to the Americas, and are distributed from southeastern United States to northern Argentina. Although relatively few bites are recorded due to their reclusive nature, semi-fossorial habits, and their occurrence in sparsely populated areas, coral snakes possess powerful venoms that target the cholinergic system and, if early treatment is missed, can cause neuromuscular paralysis, respiratory failure, and death by asphyxiation within hours of envenoming. Read More

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http://dx.doi.org/10.1016/j.jprot.2019.03.014DOI Listing
April 2019
3 Reads

Case of herpes zoster complicated by diaphragmatic paralysis.

J Dermatol 2019 Apr 2. Epub 2019 Apr 2.

Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/1346-8138.14878DOI Listing
April 2019
4 Reads

Acute Neuromuscular Respiratory Weakness Due to Acute Inflammatory Demyelinating Polyneuropathy (AIDP): A Simulation Scenario for Neurology Providers.

MedEdPORTAL 2019 Mar 1;15:10811. Epub 2019 Mar 1.

Assistant Professor of Neurology, Department of Neurology, University of Minnesota.

Introduction: Acute neuromuscular respiratory failure is a source of morbidity and mortality in neurological diseases, including acute inflammatory demyelinating polyneuropathy (AIDP), also known as Guillain-Barré syndrome. It is important for health care providers to recognize this condition and provide early ventilatory support. In this simulation, learners must assess and treat a standardized patient with acute respiratory complications related to AIDP. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415011PMC
March 2019
1 Read

Clinical and Etiological Spectrum of Hypokalemic Periodic Paralysis in a Tertiary Care Hospital in Pakistan.

Cureus 2019 Jan 19;11(1):e3921. Epub 2019 Jan 19.

Nephrology, Tulane University School of Medicine, New Orleans, USA.

Introduction Hypokalemic periodic paralysis (HPP) is characterized by muscle weakness secondary to low serum potassium levels. It may be primary in origin or there may be secondary causes like thyrotoxic periodic paralysis, renal or suprarenal causes, or non-renal causes like gastroenteritis. Aim To study the etiology, clinical manifestations, and outcome after therapy of patients with hypokalemic paralysis. Read More

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http://dx.doi.org/10.7759/cureus.3921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426562PMC
January 2019
1 Read

Virus-like particle vaccines for poliovirus types 1, 2, and 3 with enhanced thermostability expressed in insect cells.

Vaccine 2019 Apr 25;37(17):2340-2347. Epub 2019 Mar 25.

Sino-French Hoffmann Institute of Immunology, State Key Laboratory of Respiratory Disease, College of Basic Medical Science, Guangzhou Medical University, Guangzhou, China; Guangdong South China Vaccine Co. Ltd, Guangzhou, China. Electronic address:

Poliovirus (PV) is a pathogen that causes poliomyelitis, which may lead to paralysis and fatality. Inactivated PV vaccines (IPVs) and live-attenuated oral PV vaccines (OPVs) are currently used to defend against PV worldwide. Vaccines must be developed in a PV-free environment given the biosafety issues associated with OPV and IPV production and to eradicate PV globally. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.03.031DOI Listing
April 2019
13 Reads

Discovery of Quinoline Analogues as Potent Antivirals against Enterovirus D68 (EV-D68).

J Med Chem 2019 Apr 3. Epub 2019 Apr 3.

Enterovirus D68 (EV-D68) is an atypical nonpolio enterovirus that mainly infects the respiratory system of humans, leading to moderate-to-severe respiratory diseases. In rare cases, EV-D68 can spread to the central nervous system and cause paralysis in infected patients, especially young children and immunocompromised individuals. There is currently no approved vaccine or antiviral available for the prevention and treatment of EV-D68. Read More

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.9b00115
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http://dx.doi.org/10.1021/acs.jmedchem.9b00115DOI Listing
April 2019
16 Reads

Innovative management of severe tracheobronchomalacia using anterior and posterior tracheobronchopexy.

Laryngoscope 2019 Mar 25. Epub 2019 Mar 25.

Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, Massachusetts, U.S.A.

Objectives/hypothesis: Combined anterior and posterior tracheobronchopexy is a novel surgical approach for the management of severe tracheobronchomalacia (TBM). We present our institutional experience with this procedure. Our objective was to determine the utility and safety of anterior and posterior tracheopexy in the treatment of severe TBM. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lary.27938
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http://dx.doi.org/10.1002/lary.27938DOI Listing
March 2019
10 Reads

Clinical characteristics of dysphagic stroke patients with salivary aspiration: A STROBE-compliant retrospective study.

Medicine (Baltimore) 2019 Mar;98(12):e14977

Department of Rehabilitation Medicine, Daegu Fatima Hospital, Daegu, South Korea.

The aim of this study was to evaluate the correlation between radionuclide salivagram findings and clinical characteristics in stroke patient with swallowing difficulty.In this study, dysphagic stroke patients who had undergone both a radionuclide salivagram and videofluoroscopic swallowing study (VFSS) were included retrospectively. To evaluate the correlations between clinical parameters and salivary aspiration, clinical parameters, such as stroke lesion, the degree of paralysis, sex, age, onset duration of stroke, the score of the Mini-Mental State Examination (MMSE), the score of the Global Deterioration Scale (GDS), the total score of the Modified Barthel Index (MBI), and each sub-score of the MBI were collected and analyzed. Read More

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http://dx.doi.org/10.1097/MD.0000000000014977DOI Listing
March 2019
1 Read

Liuzijue Qigong: A Voice Training Method For Unilateral Vocal Fold Paralysis Patients.

Ann Otol Rhinol Laryngol 2019 Mar 21:3489419837265. Epub 2019 Mar 21.

6 Key Laboratory of Speech and Hearing Science, Ministry of Education, East China Normal University, Shanghai, China.

Objectives:: Liuzijue Qigong (LQG), a kind of traditional Chinese health exercise (TCHE), is not only widely used to strengthen physical fitness and maintain psychological well-being in the elderly but has also been utilized to help improve respiratory function. As respiratory support is an important driving force for speech production, it is logical to postulate that the LQG training method with 6 monosyllabic speech sounds, xū, hē, hū, sī, chuī, and xī, can help individuals (1) experience a relaxing and natural state of speech production, (2) eliminate voice symptoms, and (3) improve their overall body function and mood. In the current study, we hypothesized that the LQG method with these 6 sounds can be effective in improving vocal function in subjects with unilateral vocal fold paralysis (UVFP) in comparison with a conventional voice therapy method. Read More

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http://dx.doi.org/10.1177/0003489419837265DOI Listing
March 2019
7 Reads
1.054 Impact Factor

Acute Flaccid Myelitis: Lessons From Polio.

Authors:
Janet R Gilsdorf

J Pediatric Infect Dis Soc 2019 Mar 19. Epub 2019 Mar 19.

Department of Pediatrics, University of Michigan Medical School, Ann Arbor.

With the eradication of poliomyelitis in the United States, the appearance of acute flaccid myelitis outbreaks has raised questions regarding their causation. Review of the epidemiology, clinical aspects, and laboratory findings of bygone cases of poliomyelitis have revealed shows important similarities with those of newer cases of acute flaccid myelitis. Many occurrences are preceded by an apparent viral illness, and a number of viruses, particularly enteroviruses A71 and D68, can be isolated from respiratory or stool specimens. Read More

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http://dx.doi.org/10.1093/jpids/piz017DOI Listing
March 2019
1 Read

Prevalence and outcomes of Guillain-Barré syndrome among pediatrics in Saudi Arabia: a 10-year retrospective study.

Neuropsychiatr Dis Treat 2019 1;15:627-635. Epub 2019 Mar 1.

Science and Technology Unit, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia,

Background: Guillain-Barré syndrome (GBS) is a progressive acute form of paralysis most probably secondary to an immune-mediated process. GBS among Saudis has been seldom investigated, which leaves both clinicians and researchers with scarcity in knowledge. Therefore, this study aims to assess the prevalence and clinical prognosis of GBS among pediatrics admitted with acute paralysis at a large healthcare facility in Riyadh, Saudi Arabia. Read More

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http://dx.doi.org/10.2147/NDT.S187994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400135PMC
March 2019
1 Read

Amyotrophic lateral sclerosis.

Prog Med Chem 2019 8;58:63-117. Epub 2019 Mar 8.

Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL, United States.

Amyotrophic lateral sclerosis (ALS) is caused by selective and progressive loss of spinal, bulbar and cortical motoneurons and leads to irreversible paralysis, loss of speech, inability to swallow and respiratory malfunctions with the eventual death of the affected individual in a rapid disease course. Several suggested molecular pathways are reviewed including SOD1 gene mutation, protein nitrosylation, phosphorylation and oxidative stress, excitotoxicity, glutamate transporter deprivation, mitochondrial involvement, protein aggregation and motor neuron trophic factors. The role of insulin and its receptor in the brain is described. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00796468183001
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http://dx.doi.org/10.1016/bs.pmch.2018.12.001DOI Listing
March 2019
7 Reads

Unilateral diaphragmatic paralysis after laparoscopic cholecystectomy.

Rev Esp Anestesiol Reanim 2019 Mar 9. Epub 2019 Mar 9.

Servicio de Anestesiología y Reanimación y Terapéutica del Dolor, Hospital de Galdakao-Usansolo, Galdakao, Vizcaya, España.

Laparoscopic cholecystectomy is currently assumed to be the standard gold treatment of acute biliary tract pathology. Despite its many advantages compared to classical open surgery, it is not without complications. The case is presented of an 82 year-old male patient who, after the diagnosis of cholecystitis gangrenous, was urgently intervened using laparoscopic cholecystectomy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00349356193002
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http://dx.doi.org/10.1016/j.redar.2019.01.006DOI Listing
March 2019
9 Reads

43 Tinnitus as an Aura for Sleep Paralysis.

CNS Spectr 2019 Feb;24(1):199

4Smell and Taste Treatment and Research Foundation,Chicago,IL.

Objective: To understand that tinnitus may be an aura for sleep paralysis.

Background: Sleep paralysis is a transient-paralysis which occurs during awakening or falling asleep (Wilson, 1928). Those affected experience symptoms including visual, auditory, and haptic hallucinations, voluntary motor paralysis with intact ocular and respiratory motor movements, and diffuse or localized paresthesias. Read More

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http://dx.doi.org/10.1017/S1092852919000361DOI Listing
February 2019
4 Reads

Interactions Between Enteroviruses and the Inflammasome: New Insights Into Viral Pathogenesis.

Front Microbiol 2019 25;10:321. Epub 2019 Feb 25.

NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Enteroviruses (EVs) have emerged a substantial threat to public health. EVs infection range from mild to severe disease, including mild respiratory illness, diarrhea, poliomyelitis, hand, foot, and mouth disease, aseptic meningitis, and encephalitis. In the Asia-Pacific region, for example, one of the best studied enterovirus 71 (EV71) has been associated with pandemics of hand, foot, and mouth disease (HFMD) in children, particularly those under the age of five. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398425PMC
February 2019
2 Reads

Increase in Enterovirus D68 Infections in Young Children, United Kingdom, 2006-2016.

Emerg Infect Dis 2019 Jun 17;25(6). Epub 2019 Jun 17.

We determined the change in seroprevalence of enterovirus D68 (EV-D68) in the United Kingdom in age-stratified cohorts from 2006 to 2016, the period during which EV-D68 emerged as a cause of severe respiratory disease occasionally leading to paralysis. Infections were acquired primarily in infants and young children, and incidence was markedly higher in 2016. Read More

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http://dx.doi.org/10.3201/eid2506.181759DOI Listing
June 2019
1 Read

Carboxyl-terminal modulator protein regulates Akt signaling during skeletal muscle atrophy in vitro and a mouse model of amyotrophic lateral sclerosis.

Sci Rep 2019 Mar 8;9(1):3920. Epub 2019 Mar 8.

Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, IN, 46202, USA.

Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease involving motor neuron death, paralysis and, ultimately, respiratory failure. Motor neuron dysfunction leads to target skeletal muscle atrophy involving dysregulation of downstream cell survival, growth and metabolic signaling. Decreased Akt activity is linked to muscle atrophy in ALS and is associated with increased atrophy gene expression. Read More

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http://dx.doi.org/10.1038/s41598-019-40553-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408440PMC
March 2019
1 Read

Restrictive ventilatory impairment improved by laminoplasty for ossification of the posterior longitudinal ligament.

Clin Case Rep 2019 Feb 27;7(2):284-288. Epub 2018 Dec 27.

Department of Respiratory Medicine Saitama Cardiovascular and Respiratory Center Kumagaya Saitama Japan.

We report a woman with severe restrictive ventilatory impairment because of respiratory muscle paralysis caused by ossification of the posterior longitudinal ligament (OPLL). Laminoplasty improved her respiratory function and quality of life. Cervical myelopathy including OPLL should be considered as an important differential diagnosis in patients with respiratory dysfunction. Read More

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http://dx.doi.org/10.1002/ccr3.1959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389466PMC
February 2019
1 Read

Mandibular resorption and vocal cord paralysis: a catastrophic form of systemic sclerosis.

BMJ Case Rep 2019 Feb 28;12(2). Epub 2019 Feb 28.

Unidade de Doenças Auto-imunes/Medicina 7.2, Hospital de Curry Cabral, Centro Hospitalar de Lisboa Central, Lisboa, Portugal.

Sudden respiratory distress in association with severe weight loss are unusual features of systemic sclerosis (SSc). We report the case of a 56-year-old Caucasian woman with a 9-year history of a diffuse form of SSc who presented with acute stridor due to vocal cord paralysis and required an emergency tracheostomy. She had sought medical attention only after 4 years of disease onset, presenting with a mask-like face, diffuse skin thickening, acro-osteolysis and severe interstitial lung disease. Read More

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http://dx.doi.org/10.1136/bcr-2018-228262DOI Listing
February 2019
2 Reads

A Syndrome-Based Surveillance System for Infectious Diseases Among Asylum Seekers in Austrian Reception Centers, 2015-2018: Analysis of Reported Data.

JMIR Public Health Surveill 2019 Feb 27;5(1):e11465. Epub 2019 Feb 27.

Department of Surveillance and Infectious Disease Epidemiology, Institute of Medical Microbiology and Hygiene, Austrian Agency for Health and Food Safety, Vienna, Austria.

Background: Austria has been among the main European countries hosting incoming asylum seekers since 2015. Consequently, there was an urgent need to predict any public health threats associated with the arriving asylum seekers. The Department of Surveillance and Infectious Disease Epidemiology at the Austrian Agency for Health and Food Safety (AGES) was mandated to implement a national syndrome-based surveillance system in the 7 reception centers by the Austrian Ministry of Interior and Ministry of Health. Read More

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http://dx.doi.org/10.2196/11465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414818PMC
February 2019
3 Reads

Ultra-protective mechanical ventilation without extra-corporeal carbon dioxide removal for acute respiratory distress syndrome.

J Intensive Care Soc 2019 Feb 10;20(1):40-45. Epub 2018 May 10.

Department of Medicine, Division of Pulmonary, Critical Care and Environmental Medicine, University of Missouri, Columbia, MO, USA.

Background: Tidal hyperinflation can still occur with mechanical ventilation using low tidal volume (LVT) (6 mL/kg predicted body weight (PBW)) in acute respiratory distress syndrome (ARDS), despite a well-demonstrated reduction in mortality.

Methods: Retrospective chart review from August 2012 to October 2014. : Age >18years, PaO/FiO<200 with bilateral pulmonary infiltrates, absent heart failure, and ultra-protective mechanical ventilation (UPMV) defined as tidal volume (VT) <6 mL/kg PBW. Read More

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http://dx.doi.org/10.1177/1751143718774712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376584PMC
February 2019
1 Read

Immune Checkpoint Inhibitor-Induced Myositis: a Case Report and Literature Review.

Curr Rheumatol Rep 2019 Feb 21;21(4):10. Epub 2019 Feb 21.

Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.

Purpose Of The Review: We clarify clinical characteristics of patients with immune checkpoint inhibitor (ICI)-induced myositis.

Recent Findings: In 13 of 15 cases with ICI-induced myositis, the type of malignancy was melanoma. Eight, 4, and 3 patients received anti-PD-1 alone, anti-CTLA4 alone, and a combination of those, respectively. Read More

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http://dx.doi.org/10.1007/s11926-019-0811-3DOI Listing
February 2019
4 Reads

Repair of type IV laryngotracheoesophageal cleft (LTEC) on ECMO.

Pediatr Surg Int 2019 May 19;35(5):565-568. Epub 2019 Feb 19.

Department of Pediatric Surgery, Kobe Children's Hospital, 1-6-7 Minatojima Minami, Chuou-ku, Kobe, Hyogo, 650-0047, Japan.

Purpose: A type IV laryngotracheoesophageal cleft (LTEC) is a very rare congenital malformation. Type IV LTEC that extends to the carina have poor prognosis and are difficult to manage. We present our experience with surgical repair in such a case using extracorporeal membranous oxygenation (ECMO). Read More

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http://dx.doi.org/10.1007/s00383-019-04455-8DOI Listing
May 2019
4 Reads

Bilateral Diaphragmatic Paralysis: A Rare but not to be Neglected Cause of Dyspnea.

Isr Med Assoc J 2019 Feb;21(2):126-129

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Israel.

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February 2019
1 Read

Maternal respiratory distress and successful reversal with sugammadex during intrauterine transfusion with fetal paralysis.

Int J Obstet Anesth 2019 Jan 8. Epub 2019 Jan 8.

Department of Obstetrics and Gynaecology, IWK Health Centre, Halifax, Nova Scotia, Canada.

A 70 kg, 34-year-old woman at 29 weeks-of-gestation required intrauterine transfusion for Rh (D) alloimmunization. In the ambulatory treatment clinic, 19 mg of rocuronium was administered intramuscularly in split doses into the fetal buttock. The fetus moved and inadvertent maternal neuromuscular blockade occurred, leading to respiratory distress. Read More

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http://dx.doi.org/10.1016/j.ijoa.2019.01.002DOI Listing
January 2019
2 Reads

A case of stapled resection of redundant diaphragm and early evisceration of gastrointestinal content.

Wideochir Inne Tech Maloinwazyjne 2019 Jan 7;14(1):141-144. Epub 2018 Aug 7.

Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.

Diaphragm paralysis has been observed following cervical spinal cord and diaphragm injuries. Patients with diaphragm paralysis require plication of the diaphragm if significant pulmonary dysfunction occurs. We aimed to report the unsuccessful stapling technique in the correction of diaphragm paralysis. Read More

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http://dx.doi.org/10.5114/wiitm.2018.77543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372874PMC
January 2019
2 Reads
1.092 Impact Factor

An increase in reports of acute flaccid paralysis (AFP) in the United Kingdom, 1 January 2018-21 January 2019: early findings.

Euro Surveill 2019 Feb;24(6)

Members of the UK AFP task force are listed at the end of the article.

During 2018, the United Kingdom experienced an increase in reports of cases of acute flaccid paralysis (AFP). As at 21 January 2019, 40 cases had been identified with a peak in October 2018. The increase was temporally associated with an upsurge in enterovirus (EV) D68 activity. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.6.1900093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373064PMC
February 2019
1 Read

RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43.

J Mol Biol 2019 Apr 8;431(8):1671-1688. Epub 2019 Feb 8.

UK Dementia Research Institute at King's College London, London, SE5 9RT, United Kingdom; The Wohl Institute at King's College London, London, SE5 9RT, United Kingdom; Scuola Normale Superiore, Piazza dei Cavalieri, Pisa, 56126, Italy. Electronic address:

Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are incurable motor neuron diseases associated with muscle weakness, paralysis and respiratory failure. Accumulation of TAR DNA-binding protein 43 (TDP-43) as toxic cytoplasmic inclusions is one of the hallmarks of these pathologies. TDP-43 is an RNA-binding protein responsible for regulating RNA transcription, splicing, transport and translation. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.01.028DOI Listing
April 2019
8 Reads

Isolated vocal cord paralysis in two siblings with compound heterozygous variants in MUSK: Expanding the phenotypic spectrum.

Am J Med Genet A 2019 Apr 4;179(4):655-658. Epub 2019 Feb 4.

Department of Pediatrics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

The congenital myasthenic syndromes (CMS) are a heterogeneous group of disorders caused by perturbations in signal transduction at the neuromuscular junction. Defects in muscle, skeletal, receptor tyrosine kinase (MuSK) cause two distinct phenotypes: fetal akinesia with multiple congenital anomalies (Fetal akinesia deformation sequence [MIM:208150]) and early onset congenital myasthenia (myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency [MIM:616325]). Myasthenia due to MuSK deficiency has variable clinical features, ranging from a milder presentation of isolated late-onset proximal muscle weakness; to a severe presentation of prenatal-onset diffuse weakness, ophthalmoplegia, respiratory failure, and vocal cord paralysis (VCP). Read More

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http://dx.doi.org/10.1002/ajmg.a.61060DOI Listing
April 2019
1 Read

Non-aneurysmal Subarachnoid Hemorrhaging: A Rare Cause of Death in a Patient with Multiple System Atrophy.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Neurology, Kyoto University Graduate School of Medicine, Japan.

Sudden death as a result of multiple system atrophy (MSA) is usually attributed to vocal cord paralysis or disruption of breathing owing to the degeneration of the brainstem respiratory centers. However, the exact pathophysiology of sudden death is still unclear. In addition, specific causes of sudden death are not always investigated by an autopsy. Read More

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http://dx.doi.org/10.2169/internalmedicine.1567-18DOI Listing
February 2019
4 Reads

[Bilateral diaphragmatic palsy due to Lyme neuroborreliosis].

Rev Mal Respir 2019 Feb 31;36(2):197-203. Epub 2019 Jan 31.

Service des maladies respiratoires, hôpital Haut-Lévêque, centre hospitalier universitaire de Bordeaux, 33600 Pessac, France.

Introduction: Lyme disease is not uncommon and can sometimes progress to neurological complications. We report here an unusual case of bilateral diaphragmatic paralysis secondary to Lyme neuroborreliosis.

Case Report: A 79-year-old man was admitted to the intensive care unit for acute respiratory distress requiring intubation and the long-term use of nocturnal non-invasive ventilation. Read More

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http://dx.doi.org/10.1016/j.rmr.2018.07.008DOI Listing
February 2019
10 Reads

Endoscopic arytenoid abduction lateropexy for the treatment of neonatal bilateral vocal cord paralysis - Long-term results.

Int J Pediatr Otorhinolaryngol 2019 Apr 22;119:147-150. Epub 2019 Jan 22.

Department of Otorhinolaryngology and Head and Neck Surgery Faculty of Medicine, University of Szeged, Szeged, Hungary.

Objectives: Bilateral vocal cord paralysis often causes severe dyspnea requiring an early airway intervention in neonates. Endoscopic arytenoid abduction lateropexy (EAAL) with suture is a quick, reversible, minimally-invasive vocal cord lateralizing technique to enlarge the glottis. The arytenoid cartilage is directly lateralized to a normal abducted position. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.01.032DOI Listing
April 2019
1 Read

Evaluation of upper oesophageal sphincter in unilateral vocal fold paralysis.

J Laryngol Otol 2019 Feb 1;133(2):149-154. Epub 2019 Feb 1.

Department of Otolaryngology,Selcuk University Medical Faculty Hospital,Konya,Turkey.

Objective: To evaluate dysphagia and manometric changes in the upper oesophageal sphincter in patients with unilateral vocal fold paralysis.

Methods: Thirty patients with unilateral vocal fold paralysis due to vagal nerve paralysis scheduled for evaluation were enrolled in the study group; 24 healthy subjects were included in the control group. Upper oesophageal sphincter basal and residual pressure, relaxation time, and pharyngeal pressure values were evaluated by manometry. Read More

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http://dx.doi.org/10.1017/S0022215119000045DOI Listing
February 2019
3 Reads

Prospective Hospital-Based Clinical and Electrophysiological Evaluation of Acute Organophosphate Poisoning.

Ann Indian Acad Neurol 2019 Jan-Mar;22(1):91-95

Department of Medicine, Jawaharlal Nehru Medical College and KLES Dr. Prabhakar Kore Hospital and MRC, Belagavi, Karnataka, India.

Introduction: Acute organophosphate (OP) poisoning is one of the most common poisoning causing significant morbidity and mortality in developing countries. Acute cholinergic manifestations predominate with many patients requiring intensive care management and ventilator support. Nerve conduction studies including repetitive nerve stimulation can evaluate the altered neuromuscular transmission and peripheral nerve function by OPs. Read More

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http://dx.doi.org/10.4103/aian.AIAN_137_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327708PMC
January 2019
2 Reads

[A case of periodic thyrotoxic paralysis].

Authors:
G Kisoka X Bertrand

Rev Med Liege 2019 Jan;74(1):20-22

Département des Urgences, CHR Citadelle, Liège, Belgique.

Periodic thyrotoxic paralysis (TPP) is a disease that usually affects Asian men from 20 to 50 years. It is secondary to genetic mutations of ion channels for the transport of sodium and potassium. It is characterized by recurrent and brutal bouts of paresis / flaccid paralysis, without sensory involvement, in a context of hyperthyroidism. Read More

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January 2019
10 Reads

[Key technology of lymph node dissection along recurrent laryngeal nerve and its associated complication prevention in patients with thoracic esophageal cancer].

Zhonghua Zhong Liu Za Zhi 2019 Jan;41(1):1-5

Department of Thoracic Surgery, National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.

Esophageal cancer is one of the most prevalent cancers in China. Lymph node metastasis is one of the most important prognostic factors and severely affect the long-term survival after surgical treatment. Therefore, systemic two-field lymph node dissection including thoracic and abdominal draining nodes of the esophagus during surgery is essential in order to improve the long-term survival for the patients with thoracic esophageal cancer, and it is also the basis for precise staging and postoperative adjuvant treatment regimen- making. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.01.001DOI Listing
January 2019
1 Read

Persistent diaphragmatic paralysis associated with interscalene nerve block after total shoulder arthroplasty: a case report.

JSES Open Access 2018 Oct 22;2(3):165-168. Epub 2018 Jun 22.

Division of Sports Medicine & Shoulder Surgery, Department of Orthopaedic Surgery, Midwest Orthopaedics at Rush, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.jses.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334858PMC
October 2018
2 Reads

Atypical Clinical Presentations of Pediatric Acute Immune-Mediated Polyneuropathy.

J Child Neurol 2019 Apr 23;34(5):268-276. Epub 2019 Jan 23.

2 Institute of Child Neurology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis in children. During the acute phase, the disorder can be life-threatening by involving the respiratory muscles and the autonomic nervous system. Nevertheless, the prognosis is good, and most children achieve full recovery. Read More

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http://journals.sagepub.com/doi/10.1177/0883073818825213
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http://dx.doi.org/10.1177/0883073818825213DOI Listing
April 2019
7 Reads

Genomic Analyses of Acute Flaccid Myelitis Cases among a Cluster in Arizona Provide Further Evidence of Enterovirus D68 Role.

MBio 2019 01 22;10(1). Epub 2019 Jan 22.

Pathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA

Enteroviruses are a common cause of respiratory and gastrointestinal illness, and multiple subtypes, including poliovirus, can cause neurologic disease. In recent years, enterovirus D68 (EV-D68) has been associated with serious neurologic illnesses, including acute flaccid myelitis (AFM), frequently preceded by respiratory disease. A cluster of 11 suspect cases of pediatric AFM was identified in September 2016 in Phoenix, AZ. Read More

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http://dx.doi.org/10.1128/mBio.02262-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343034PMC
January 2019
4 Reads

Acute flaccid myelitis caused by enterovirus D68: Case definitions for use in clinical practice.

Eur J Paediatr Neurol 2019 Mar 11;23(2):235-239. Epub 2019 Jan 11.

Paediatric Neurosciences, Royal Hospital for Sick Children, Edinburgh, UK; Child Life and Health, University of Edinburgh, Edinburgh, UK.

Acute flaccid myelitis (AFM) was increasingly detected in recent years, coinciding with upsurges of enterovirus D68 (EV-D68) infections. We reviewed the evidence for a causal relationship between both. Based on reported cases, we provide case definitions for AFM caused by EV-D68 infections to enable a standard procedure for affected patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10903798183028
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http://dx.doi.org/10.1016/j.ejpn.2019.01.001DOI Listing
March 2019
16 Reads

Recurrent bacterial pneumonia in Irish Wolfhounds: Clinical findings and etiological studies.

J Vet Intern Med 2019 Mar 21;33(2):846-855. Epub 2019 Jan 21.

Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.

Background: Increased incidence of bacterial pneumonia (BP) has been reported in Irish Wolfhounds (IWHs), and recurrence of BP is common. The etiology of recurrent pneumonia in IWHs is largely unknown.

Objectives: To describe clinical findings in IWHs with recurrent BP and investigate possible etiologies. Read More

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http://dx.doi.org/10.1111/jvim.15413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430867PMC
March 2019
2 Reads

Risk factors and outcomes of vocal cord paralysis after lung transplantation - a retrospective cohort study.

Transpl Int 2019 Jan 21. Epub 2019 Jan 21.

Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.

Vocal cord paralysis (VCP) may complicate thoracic surgery and is associated with increased morbidity and mortality. Among lung transplant (LTx) recipients, chronic pulmonary aspiration can contribute to chronic allograft dysfunction (CLAD). We herein assessed the unknown incidence and clinical impact of VCP in a large LTx cohort. Read More

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http://dx.doi.org/10.1111/tri.13402DOI Listing
January 2019
4 Reads

Neurotoxic envenomation by the South African coral snake (Aspidelaps lubricus): A case report.

Toxicon 2019 Mar 17;159:38-40. Epub 2019 Jan 17.

Division of Medical Toxicology, Department of Emergency Medicine, University of Pittsburgh School of Medicine, Iroquois Building Suite 400, 3600 Forbes Ave, Pittsburgh, PA 15213, USA. Electronic address:

The South African coral snake (Aspidelaps lubricus, Elapidae) has not previously been reported to cause any neurotoxic envenomations in humans. We recently treated a 44-year-old man who was bitten twice, once in each hand, by a captive South African coral snake (Aspidelaps lubricus) while feeding the female snake who had recently laid eggs. Approximately one hour after receiving the bite, he developed vomiting, respiratory failure requiring mechanical ventilation, and paralysis of the bulbar and upper extremity muscles, with retention of voluntary motor control in the lower extremities. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00410101193001
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http://dx.doi.org/10.1016/j.toxicon.2019.01.001DOI Listing
March 2019
16 Reads

Effect of local anesthetic volume (20 mL vs 30 mL ropivacaine) on electromyography of the diaphragm and pulmonary function after ultrasound-guided supraclavicular brachial plexus block: a randomized controlled trial.

Reg Anesth Pain Med 2019 Jan;44(1):69-75

Department of Anesthesiology, The 98th Clinical College of PLA, Anhui Medical University, Huzhou, China

Background And Objectives: Diaphragmatic paralysis following supraclavicular brachial plexus block (SCBPB) is ascribed to phrenic nerve palsy. This study investigated the effect of 2 volumes of 0.375% ropivacaine on efficacy of block as a surgical anesthetic and as an analgesic and examined diaphragm compound muscle action potentials (CMAPs) and pulmonary function before and after SCBPB. Read More

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http://dx.doi.org/10.1136/rapm-2018-000014DOI Listing
January 2019
3 Reads