5,887 results match your criteria Diaphragmatic Paralysis


Guillain-Barré Syndrome as a Neurological Complication of Novel COVID-19 Infection: A Case Report and Review of the Literature.

Neurologist 2020 Jul;25(4):101-103

Department of Neurology, Bou Ali Sina Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.

Introduction: The novel coronavirus (COVID-19) is a global pandemic. Although the main clinical manifestation of COVID-19 is respiratory involvement, there is evidence suggesting the neuroinvasive potential of COVID-19. There are limited reports of neurological complications of COVID-19 infection in the literature. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000291DOI Listing

Assessment of diaphragmatic function by ultrasonography: Current approach and perspectives.

World J Clin Cases 2020 Jun;8(12):2408-2424

Service d'Explorations Fonctionnelles Respiratoires, CHU Nord, Assistance Publique des Hôpitaux de Marseille et Aix Marseille Université, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille 13015, France.

This article reports the various methods used to assess diaphragmatic function by ultrasonography. The excursions of the two hemidiaphragms can be measured using two-dimensional or M-mode ultrasonography, during respiratory maneuvers such as quiet breathing, voluntary sniffing and deep inspiration. On the zone of apposition to the rib cage for both hemidiaphragms, it is possible to measure the thickness on expiration and during deep breathing to assess the percentage of thickening during inspiration. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i12.2408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322428PMC

First Onset Hypokalemic Periodic Paralysis Following Surgery for Myxopapillary Ependymoma, Case Report.

World Neurosurg 2020 Jun 22. Epub 2020 Jun 22.

George Emil Palade University of Medicine, Pharmacy, Science and Technology, Tîrgu MureȘ, Romania; Department of Neurology, Tîrgu MureȘ County Clinical Emergency Hospital, Tîrgu MureȘ, Romania.

Background: Hypokalemic periodic paralysis is a rare skeletal muscle channelopathy characterized by intermittent episodes of acute flaccid paralysis with associated hypokalaemia. We present here the case of a first-onset hypokalemic periodic paralysis triggered by a lumbar spinal surgery for tumor resection.

Case Description: A 37-years old male, without any known prior medical conditions who presented with a first-onset attack of hypokalemic paralysis 1. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.109DOI Listing

Critical upper airway obstruction as the first symptom of acute myeloid leukemia - an anesthesiologic reminder.

Clin Pract 2020 May 10;10(2):1214. Epub 2020 Jun 10.

Department of Medicine, Haukeland University Hospital.

Acute upper airway obstruction can be fatal. Early recognition of airway distress followed by diagnostic laryngoscopy and prompt intervention to secure airway control is crucial. We here present a 62-year old male patient who presented with cough and increasing respiratory distress for three weeks. Read More

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http://dx.doi.org/10.4081/cp.2020.1214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296277PMC

Predictors of a complicated course after surgical repair of tetralogy of Fallot.

Turk Gogus Kalp Damar Cerrahisi Derg 2019 Jun 22;28(2):264-273. Epub 2020 Apr 22.

Department of Pediatric Cardiovascular Surgery, Mehmet Akif Ersoy Thoracic and Cardiovascular Training and Research Hospital, Istanbul, Turkey.

Background: In this study, we aimed to evaluate the patient and surgical factors affecting prolonged hospital stay and major adverse events after surgical repair of tetralogy of Fallot and to identify the predictors of a complicated course after surgical repair.

Methods: A total of 170 consecutive patients (96 males, 74 females; median age 12 months; range, 1 to 192 months) who underwent surgical repair of tetralogy of Fallot between January 2015 and April 2018 were retrospectively reviewed. A mechanical ventilation duration of >24 h, an intensive care unit stay of >3 days, and a hospital stay of >7 days were considered as prolonged. Read More

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http://dx.doi.org/10.5606/tgkdc.dergisi.2020.18829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298368PMC

Neurobiology of COVID-19.

J Alzheimers Dis 2020 ;76(1):3-19

Neuroradiology Section, Mallinckrodt Institute of Radiology at Washington University in St. Louis, St. Louis, MO, USA.

Anosmia, stroke, paralysis, cranial nerve deficits, encephalopathy, delirium, meningitis, and seizures are some of the neurological complications in patients with coronavirus disease-19 (COVID-19) which is caused by acute respiratory syndrome coronavirus 2 (SARS-Cov2). There remains a challenge to determine the extent to which neurological abnormalities in COVID-19 are caused by SARS-Cov2 itself, the exaggerated cytokine response it triggers, and/or the resulting hypercoagulapathy and formation of blood clots in blood vessels throughout the body and the brain. In this article, we review the reports that address neurological manifestations in patients with COVID-19 who may present with acute neurological symptoms (e. Read More

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http://dx.doi.org/10.3233/JAD-200581DOI Listing
January 2020

Vocal Cord and Diaphragmatic Paralysis in a Patient With Bilateral Mediastinal Neurofibromatosis Type 1.

Ear Nose Throat J 2020 Jun 12:145561320933959. Epub 2020 Jun 12.

Department of Radiology, Daedong Hospital, Busan, Republic of Korea.

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http://dx.doi.org/10.1177/0145561320933959DOI Listing

West Nile Virus-associated Hospitalizations, California, USA, 2004-2017.

Clin Infect Dis 2020 Jun 11. Epub 2020 Jun 11.

Infectious Diseases Branch, Division of Communicable Disease Control, California Department of Public Health, Sacramento and Richmond, California, USA.

Background: West Nile virus (WNV) is the most commonly reported mosquito-borne disease in the United States. California reports more WNV disease than any other state.

Methods: We identified WNV-associated hospitalizations from 2004 through 2017 in California and estimated hospitalization incidence using California Patient Discharge Data. Read More

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http://dx.doi.org/10.1093/cid/ciaa749DOI Listing

Ascending Paralysis in a 36-Year-Old Woman With Bipolar Disorder and Recent Aspiration Pneumonia.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620931649

Louisiana State University Health Sciences Center, New Orleans, LA, USA.

Guillain-Barré syndrome (GBS) is an acute inflammatory demyelinating polyneuropathy affecting both motor and sensory peripheral nerves. Typically presenting after a gastrointestinal or a respiratory tract infection, it manifests as ascending paralysis with concomitant areflexia in patients. Cytoalbuminologic dissociation is a supportive finding on cerebrospinal fluid (CSF) analysis. Read More

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http://dx.doi.org/10.1177/2324709620931649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290259PMC

Venomics and biochemical analysis of the black-tailed horned pitviper, Mixcoatlus melanurus, and characterization of Melanurutoxin, a novel crotoxin homolog.

J Proteomics 2020 Jun 7:103865. Epub 2020 Jun 7.

Laboratorio de Venómica Evolutiva y Traslacional, Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas, Jaime Roig 11, 46010, Valencia, Spain. Electronic address:

We report a structural and functional venomics characterization of the black-tailed horned pitviper, Mixcoatlus melanurus. The venom phenotype of this small and elusive pitviper endemic to México comprise peptides and proteins of 16 toxin families whose relative abundance mirror those of neurotoxic (type II) venoms described for some species within genera distributed in Central Asia (Gloydius) and the Americas (Sistrurus, Crotalus, Ophryacus, and Bothriechis). A novel β-neurotoxic heterodimeric PLA, termed Melanurutoxin was characterized. Read More

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http://dx.doi.org/10.1016/j.jprot.2020.103865DOI Listing

Respiratory Distress in SARS-CoV-2 without Lung Damage: Phrenic Paralysis Should Be Considered in COVID-19 Infection.

Eur J Case Rep Intern Med 2020 21;7(6):001728. Epub 2020 May 21.

Hôpitaux Privés de Metz, Metz, France.

We describe an overweight COVID-19 patient with respiratory distress preceded by anosmia/dysgeusia with no lung injury shown on CT, angio-CT or ventilation/perfusion scans. Orthopnoea and paradoxical abdominal respiration were identified. Phrenic paralysis, demonstrated by examination of patient breathing, and on x-ray while standing breathing in and out, explained the respiratory distress. Read More

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http://dx.doi.org/10.12890/2020_001728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279902PMC

[Clinical analysis and laboratory diagnosis of three cases with infantile botulism caused by type B].

Zhonghua Er Ke Za Zhi 2020 Jun;58(6):499-502

Department of Veterinary Medicine, College of Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China.

To summarize the clinical characteristics and laboratory diagnostic methods of infant botulism caused by type B. Clinical data of 3 infants with type B botulism who were admitted to Children's Hospital Affiliated to Capital Institute of Pediatrics from May to November 2018 were retrospectively analyzed. Botulinum toxin was detected in fecal samples or fecal enrichment solution of the patients, and was cultured and isolated from fecal samples. Read More

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http://dx.doi.org/10.3760/cma.j.cn112140-20191101-00691DOI Listing

Botulism disguised as parotitis.

IDCases 2020 25;21:e00839. Epub 2020 May 25.

Infectious Diseases Department, Centro Hospitalar Universitário de São João, Portugal.

Botulism is an acute toxin-mediated neuroparalytic syndrome caused by some species. It typically presents itself as an acute symmetric descending paralysis of cranial and peripheral nerves, which can potentially evolve to respiratory failure and death. We report a case of botulism diagnosed in a patient presenting with a parotitis probably due to xerostomia, even though he had already sought medical assistance for blurred vision and dysphagia. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264047PMC

Pontine Tegmentum Lesions Accompanying Myelitis During an Enterovirus Outbreak: Differential Diagnosis and Outcome.

J Child Neurol 2020 Jul;35(8):501-508

Department of Pediatric Neurology, Ihsan Doğramaci Children's Hospital, Faculty of Medicine, Hacettepe University, Ankara.

Aim: To investigate etiology and prognostic significance of pontine tegmentum lesions accompanying a cluster of acute flaccid myelitis.

Method: We retrospectively examined patients from 6 centers in Turkey who manifested encephalitis or myelitis associated with dorsal pontine lesions on magnetic resonance imaging (MRI) between July 2018 and February 2019.

Results: Twenty-two patients were evaluated. Read More

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http://dx.doi.org/10.1177/0883073820911737DOI Listing

Thirty years of translational research in Mobility Medicine: Collection of abstracts of the 2020 Padua Muscle Days.

Authors:
Ugo Carraro

Eur J Transl Myol 2020 Apr 1;30(1):8826. Epub 2020 Apr 1.

Interdepartmental Research Centre of Myology (CIR-Myo), Department of Biomedical Sciences, University of Padova, Italy.

More than half a century of skeletal muscle research is continuing at Padua University (Italy) under the auspices of the Interdepartmental Research Centre of Myology (CIR-Myo), the European Journal of Translational Myology (EJTM) and recently also with the support of the A&CM-C Foundation for Translational Myology, Padova, Italy. The Volume 30(1), 2020 of the EJTM opens with the collection of abstracts for the conference "2020 Padua Muscle Days: Mobility Medicine 30 years of Translational Research". This is an international conference that will be held between March 18-21, 2020 in Euganei Hills and Padova in Italy. Read More

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http://dx.doi.org/10.4081/ejtm.2019.8826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254447PMC

Two Cases of Infant Botulism Presenting with Altered Mental Status.

Hawaii J Health Soc Welf 2020 May;79(5 Suppl 1):101-103

Tripler Army Medical Center, Honolulu, HI.

Infant botulism is a progressive process described as starting with descending weakness, facial palsies and constipation. Loss of bulbar reflexes and flaccid paralysis are common in infants less than 6 months old who have infant botulism. , the bacteria that produce the toxin that causes this condition, are ubiquitous in the United States including Hawai'i, but infant botulism is rarely reported here. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260868PMC

Rats Lacking Dopamine Transporter Display Increased Vulnerability and Aberrant Autonomic Response to Acute Stress.

Biomolecules 2020 May 31;10(6). Epub 2020 May 31.

Department of Neurology and Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

The activity of the hypothalamus-pituitary-adrenal (HPA) axis is pivotal in homeostasis and presides the adaptative response to stress. Dopamine Transporter (DAT) plays a key role in the regulation of the HPA axis. We used young adult female DAT Knockout (KO) rats to assess the effects of DAT ablation (partial, heterozygous DAT+/-, or total, homozygous DAT-/-) on vulnerability to stress. Read More

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http://dx.doi.org/10.3390/biom10060842DOI Listing

Upper airway obstruction during extubation after general anesthesia, in a patient with Parkinson disease: A case report.

Medicine (Baltimore) 2020 May;99(21):e20363

Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing Jiangsu, P.R. China.

Rationale: Parkinson disease (PD) is a chronic neurodegenerative condition often suffered by the elderly. Upper airway obstruction, though rare in patients with PD, can be life threatening and is associated with vocal cord paralysis, laryngeal spasm, and dystonia of jaw and neck muscles.

Patient Concerns: We describe a life-threatening upper airway obstruction caused by bilateral vocal cord paralysis, in an elderly man with PD, during extubation after general anesthesia. Read More

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http://dx.doi.org/10.1097/MD.0000000000020363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249898PMC

Bronchial Visualization of Tetanic Contractions: A Case Report.

Am J Case Rep 2020 Jun 1;21:e923349. Epub 2020 Jun 1.

School of Medicine, San Francisco de Quito University, Quito, Ecuador.

BACKGROUND Tetanus is a potentially fatal infectious disease which, during its evolution, creates multiple complications, usually requiring intensive management and care. CASE REPORT We present a clinical case of a 59-year-old male patient with generalized tetanus admitted to the intensive care unit. Flexible bronchoscopy revealed contraction of the bronchial demonstrating that tetany existed at the respiratory level, which rarely becomes evident. Read More

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http://dx.doi.org/10.12659/AJCR.923349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304649PMC

Guillain-Barré syndrome related to SARS-CoV-2 infection.

Neurol Neuroimmunol Neuroinflamm 2020 09 27;7(5). Epub 2020 May 27.

From the Service de Neurologie (K.B., P.V., L.K., J.-B.C., J.S.), Hôpitaux Universitaires de Strasbourg; Service de Neurologie (M.M.), Centre Hospitalo-Universitaire de Grenoble Alpes, La Tronche; Service de Neuroradiologie (S.B.), Hôpitaux Universitaires de Strasbourg; Institut de Biologie Structurale (IBS) (B.N., P.M.), Université de Grenoble Alpes, CEA, CNRS; Laboratoire de virologie (B.N., P.M.), Centre Hospitalo-Universitaire de Grenoble Alpes, La Tronche; Service d'Accueil des Urgences (F.B.), Hôpitaux Universitaires de Strasbourg; and Service de Réanimation Polyvalente Chirurgicale (A.G.), Centre Hospitalo-Universitaire de Grenoble Alpes, La Tronche, France.

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http://dx.doi.org/10.1212/NXI.0000000000000785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286648PMC
September 2020

Veno-venous Extracorporeal Membrane Oxygenation for Respiratory Failure in COVID-19 Patients: Early Experience From a Major Academic Medical Center in North America.

Ann Surg 2020 May 25. Epub 2020 May 25.

Division of Cardiac Surgery, Massachusetts General Hospital, Boston, Massachusetts.

And Background Data: VV ECMO can be utilized as an advanced therapy in select patients with COVID-19 respiratory failure refractory to traditional critical care management and optimal mechanical ventilation. Anticipating a need for such therapies during the pandemic, our center created a targeted protocol for ECMO therapy in COVID-19 patients that allows us to provide this life-saving therapy to our sickest patients without overburdening already stretched resources or excessively exposing healthcare staff to infection risk.

Methods: As a major regional referral program, we used the framework of our well-established ECMO service-line to outline specific team structures, modified patient eligibility criteria, cannulation strategies, and management protocols for the COVID-19 ECMO program. Read More

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http://dx.doi.org/10.1097/SLA.0000000000004084DOI Listing

Ultrasound diaphragmatic manual and semi-automated motion measurements: Application in simulated and in vivo data of critically ill subjects.

Comput Methods Programs Biomed 2020 May 5;194:105517. Epub 2020 May 5.

Department of Computer Science, University of Cyprus, Nicosia, Cyprus. Electronic address:

Background And Objective: Ultrasound diaphragmatic muscle motion characteristics may provide useful information about normal or abnormal diaphragmatic function and indicate diaphragmatic weakness, or paralysis. In the present work we propose and evaluate an integrated semi-automated analysis system for the quantitative analysis of ultrasonic motion from ultrasound diaphragmatic videos.

Methods: The proposed system was evaluated in simulated videos and in 13 patients, four of whom patients were mechanically ventilated. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105517DOI Listing

Sleep-related breathing disorders associated with the characteristics of underlying congenital rare diseases of Moebius syndrome and Poland syndrome.

Respirol Case Rep 2020 Jul 18;8(5):e00579. Epub 2020 May 18.

Division of Respiratory Medicine Juntendo University Faculty of Medicine & Graduate School of Medicine Tokyo Japan.

A 24-year-old woman was referred to us with daytime sleepiness. She has two congenital intractable and rare diseases, namely, Moebius syndrome and Poland syndrome. Physiological examinations and a detailed usage analysis under a ventilation device helped to conclude that hypoglossal nerve paralysis and thoracic deformity from her two underlying diseases were associated closely with her final diagnosis of obstructive sleep apnoea and sleep-related hypoventilation due to medical disorders. Read More

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http://dx.doi.org/10.1002/rcr2.579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235444PMC

Safety of Same Day Discharge after Atrial Fibrillation Ablation.

J Atr Fibrillation 2020 Feb-Mar;12(5):2150. Epub 2020 Feb 28.

Our Lady of Lourdes Hospital, Camden, NJ, U.S.

Introduction: It is routine practice to observe patients (pts) overnight in the hospital after atrial fibrillation (AF) ablation. We report single center experience comparing the rate of complications prior to and after implementing a strategy of same day discharge (SDD) following AF ablation.

Objective: To assess the safety of SDD after AF ablation. Read More

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http://dx.doi.org/10.4022/jafib.2150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237085PMC
February 2020

Laryngeal stent for acute and chronic respiratory distress in seven dogs with laryngeal paralysis.

Open Vet J 2020 Apr 16;10(1):4-10. Epub 2020 Jan 16.

Unidad de Endoscopia Peroral Hospital de Infecciosas "F. Muñiz", Uspallata 2272, C1282AEN CABA, Argentina.

Background: Laryngeal paralysis, failure of arytenoid cartilage, and vocal fold abduction are commonly seen in older medium to large breed dogs. Observation of laryngeal function in dogs and cats is performed by transoral visualization. There are a variety of surgical techniques; aspiration pneumonia is the most common complication associated with surgical correction of laryngeal paralysis. Read More

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http://dx.doi.org/10.4314/ovj.v10i1.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193885PMC

Facial diplegia, a possible atypical variant of Guillain-Barré Syndrome as a rare neurological complication of SARS-CoV-2.

J Clin Neurosci 2020 Jul 14;77:230-232. Epub 2020 May 14.

Medical Resident at the Department of Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

We present a case of facial diplegia after 10 days of SARS-CoV-2 confirmed infection symptoms in a 61 year old patient without prior clinically relevant background. There are few known cases of Guillain-Barré Syndrome (GBS) related to SARS-CoV-2 infection; we propose this case as a rare variant of GBS in COVID-19 infection context, due to Its chronology, clinical manifestations and cerebrospinal fluid (CSF) findings. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221378PMC

Bilateral vocal cord paralysis after endoscopic placement of fully covered self-expandable metal stent for palliative treatment of malignant proximal esophageal obstruction: two case reports.

BMC Gastroenterol 2020 May 14;20(1):153. Epub 2020 May 14.

Department of Respiratory Diseases and Intensive Care, Reference Center for Adult Rare Pulmonary Diseases, University Hospital of Dijon - Bourgogne, Dijon, France.

Background: Oesophageal stents have several well-known respiratory complications, including aspiration pneumonia, fistula and airway compression. However, bilateral vocal cord paralysis has rarely been described.

Methods: We describe two patients who presented with refractory dysphagia due to malignant proximal oesophageal strictures. Read More

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http://dx.doi.org/10.1186/s12876-020-01300-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227230PMC

Unilateral diaphragmatic paralysis associated with surgical mitral valve repair in dogs.

J Vet Cardiol 2020 Jun 20;29:33-39. Epub 2020 Mar 20.

JASMINE Veterinary Cardiovascular Medical Center, 2-7-3 Nakagawa, Tsuzuki, Yokohama, Kanagawa 224-0001, Japan. Electronic address:

Objectives: Unilateral diaphragmatic paralysis (UDP) due to phrenic nerve injury is a potential complication of thoracic surgery. This study evaluated the prevalence of UDP associated with surgical mitral valve repair (MVR) and its effect on surgical outcomes in dogs.

Animals, Materials And Methods: Two hundred ninety-four dogs that underwent MVR were included in the study. Read More

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http://dx.doi.org/10.1016/j.jvc.2020.03.001DOI Listing

Early Guillain-Barré syndrome in coronavirus disease 2019 (COVID-19): a case report from an Italian COVID-hospital.

Neurol Sci 2020 Jun 12;41(6):1351-1354. Epub 2020 May 12.

Neurology Unit, Rovereto Hospital, Azienda Provinciale per i Servizi Sanitari (APSS) di Trento, Trento, Italy.

Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy associated with dysimmune processes, often related to a previous infectious exposure. During Italian severe acute respiratory syndrome coronavirus-2 outbreak, a woman presented with a rapidly progressive flaccid paralysis with unilateral facial neuropathy after a few days of mild respiratory symptoms. Coronavirus was detected by nasopharyngeal swab, but there was no evidence of its presence in her cerebrospinal fluid, which confirmed the typical albumin-cytological dissociation of GBS, along with consistent neurophysiological data. Read More

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http://dx.doi.org/10.1007/s10072-020-04449-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216127PMC

Gastric lymphoma complicated by phlegmonous gastritis and Guillain-Barré syndrome: A case report.

Medicine (Baltimore) 2020 May;99(18):e20030

Department of Hematology.

Introduction: Complications such as severe infection may occur during the chemotherapy of malignant lymphoma. Phlegmonous gastritis (PG) is a rare acute bacterial infection associated with high mortality, requiring early diagnosis, and prompt management. In addition, Guillain-Barré syndrome (GBS) occasionally requires early treatment and intensive care management due to the occurrence of severe neuropathy and respiratory failure. Read More

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http://dx.doi.org/10.1097/MD.0000000000020030DOI Listing

Neonatal Vocal Fold Paralysis.

Neoreviews 2020 May;21(5):e308-e322

Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD.

Vocal fold paralysis (VFP) is an important cause of respiratory and feeding compromise in infants. The causes of neonatal VFP are varied and include central nervous system disorders, birth-related trauma, mediastinal masses, iatrogenic injuries, and idiopathic cases. Bilateral VFP often presents with stridor or respiratory distress and can require rapid intervention to stabilize an adequate airway. Read More

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http://dx.doi.org/10.1542/neo.21-5-e308DOI Listing

Case Study of Phrenic Nerve Paralysis: "I Can't Breathe!"

J Emerg Med 2020 Apr 27. Epub 2020 Apr 27.

Emergency Department, Henry Ford Allegiance Health, Jackson, Michigan.

Background: The anatomic course of the phrenic nerve runs in the fascia covering the anterior scalene muscle. Interscalene blocks are commonly performed by an anesthesiologist for shoulder surgery, such as a rotator cuff repair, total shoulder replacement, humeral fracture, or other arm surgery. Phrenic nerve palsy or paralysis is a known complication from interscalene block and is covered in multiple case reports and series in both Anesthesia and Neurosurgical literature, but only one case report in the Emergency Medicine literature. Read More

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http://dx.doi.org/10.1016/j.jemermed.2020.03.023DOI Listing

Perspectives for the use of therapeutic Botulinum toxin as a multifaceted candidate drug to attenuate COVID-19.

Authors:
Mahesh Kandasamy

Med Drug Discov 2020 Apr 29:100042. Epub 2020 Apr 29.

Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, -620024, Tamil Nadu, India.

The recent outbreak of coronavirus disease (COVID-19) resulting from a distinctive severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to evolve in many countries and pose life-threatening clinical issues to global public health. While the lungs are the primary target for the SARS-CoV-2-mediated pathological consequence, SARS-CoV-2 appear to invade the brain and cause neurological deficits. In the later stage, COVID-19 can progress to pneumonia, acute respiratory failure, neurological deficits and multi-organ dysfunctions leading to death. Read More

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http://dx.doi.org/10.1016/j.medidd.2020.100042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189194PMC

Identification and Quality Evaluation of Raw and Processed Species Using Microscopy, DNA Barcoding, and Gas Chromatography-Mass Spectrometry.

J Anal Methods Chem 2020 13;2020:2690238. Epub 2020 Apr 13.

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin.301617, China.

(Aristolochiaceae) is one of the common herbs used to relieve exterior syndromes. Some volatile components of which have toxic effect may cause adverse reactions such as headache, general tension, unconsciousness, and respiratory paralysis. Therefore, is normally processed to reduce such toxicity and adverse effects. Read More

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http://dx.doi.org/10.1155/2020/2690238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174948PMC

Laryngeal Evaluation during the COVID-19 Pandemic: Transcervical Laryngeal Ultrasonography.

Otolaryngol Head Neck Surg 2020 07 28;163(1):51-53. Epub 2020 Apr 28.

Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Stanford University, Stanford, California, USA.

The novel coronavirus disease (COVID-19), caused by the SARS-CoV-2 virus, has quickly become a global pandemic since its initial outbreak in China in late 2019. Institutions are faced with the challenge of upholding the standard of care while maintaining safety for health care personnel and patients. Due to the common performance of aerosol-generating endoscopic procedures in the upper respiratory tract, otolaryngologists are at uniquely high risk for potential infection. Read More

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http://dx.doi.org/10.1177/0194599820922984DOI Listing

Recurrent aspiration pneumonia due to bilateral associated laryngeal paralysis after tooth extraction under general anesthesia: a case report.

JA Clin Rep 2020 Apr 25;6(1):29. Epub 2020 Apr 25.

Department of Anesthesiology, Tokyo Dental College Ichikawa General Hospital, 5-11-13 Sugano, Ichikawa City, Chiba, 272-8513, Japan.

Background: Associated laryngeal paralysis is a clinical condition merged with other cranial nerve disorders associated with vocal cord paralysis. It is a rare complication in patients after general anesthesia. Here, we report our experience with a patient who developed associated laryngeal paralysis after oral surgery. Read More

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http://dx.doi.org/10.1186/s40981-020-00335-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183513PMC

Mutations and Their Clinical Presentations: New Case Report and Systematic Review.

Case Rep Med 2020 13;2020:8795607. Epub 2020 Apr 13.

School of Medicine, Lebanese University, Beirut, Lebanon.

Lethal congenital contracture syndrome type 7 (LCCS7) and congenital hypomyelinating neuropathy type 3 (CHN3) are rare autosomal recessive diseases, characterized by severe neonatal hypotonia, polyhydramnios, arthrogryposis, facial diplegia, and severe motor paralysis, leading to death in early infancy. They are related to mutations in the (contactin associated protein 1) gene, playing an important role in myelination. Recent studies have shown that both diseases could present with a wide phenotypic spectrum, with promising survival up to early childhood. Read More

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http://dx.doi.org/10.1155/2020/8795607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174947PMC

Molecular Pathogenicity of Enteroviruses Causing Neurological Disease.

Front Microbiol 2020 9;11:540. Epub 2020 Apr 9.

Viral Diseases Division, National Microbiology Laboratory, Winnipeg, MB, Canada.

Enteroviruses are single-stranded positive-sense RNA viruses that primarily cause self-limiting gastrointestinal or respiratory illness. In some cases, these viruses can invade the central nervous system, causing life-threatening neurological diseases including encephalitis, meningitis and acute flaccid paralysis (AFP). As we near the global eradication of poliovirus, formerly the major cause of AFP, the number of AFP cases have not diminished implying a non-poliovirus etiology. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161091PMC

Posterior spinal fusion for severe kyphoscoliosis in a Loeys-Dietz syndrome patient with a large syringomyelia.

J Clin Neurosci 2020 Jun 21;76:211-213. Epub 2020 Apr 21.

Department of Orthopaedic Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.

Spinal deformity is a characteristic feature of Loeys-Dietz syndrome (LDS). Surgical correction in LDS is indicated when the deformity is progressive to avoid neurological deficits, respiratory impairment, and back pain. However, few reports exist on the surgical treatment of spinal deformity in LDS, and no therapeutic standards have been established. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.04.017DOI Listing

Tidal Volume Lowering by Instrumental Dead Space Reduction in Brain-Injured ARDS Patients: Effects on Respiratory Mechanics, Gas Exchange, and Cerebral Hemodynamics.

Neurocrit Care 2020 Apr 22. Epub 2020 Apr 22.

Department of Medical, Oral and Biotechnological Sciences, School of Medicine and Health Sciences, Section of Anesthesia, Analgesia, Perioperative and Intensive Care, SS. Annunziata Hospital, Gabriele d'Annunzio University of Chieti-Pescara, Via dei Vestini, 66100, Chieti, Italy.

Background: Limiting tidal volume (V), plateau pressure, and driving pressure is essential during the acute respiratory distress syndrome (ARDS), but may be challenging when brain injury coexists due to the risk of hypercapnia. Because lowering dead space enhances CO clearance, we conducted a study to determine whether and to what extent replacing heat and moisture exchangers (HME) with heated humidifiers (HH) facilitate safe V lowering in brain-injured patients with ARDS.

Methods: Brain-injured patients (head trauma or spontaneous cerebral hemorrhage with Glasgow Coma Scale at admission < 9) with mild and moderate ARDS received three ventilatory strategies in a sequential order during continuous paralysis: (1) HME with V to obtain a PaCO within 30-35 mmHg (HME1); (2) HH with V titrated to obtain the same PaCO (HH); and (3) HME1 settings resumed (HME2). Read More

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http://dx.doi.org/10.1007/s12028-020-00969-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224122PMC

Guillain-Barré Syndrome After a Gunshot Wound to the Thoracic Spine.

World Neurosurg 2020 Apr 18;139:175-178. Epub 2020 Apr 18.

Department of Trauma Surgery, Advocate Christ Medical Center, Oak Lawn, Illinois, USA.

Background: Guillain-Barré syndrome (GBS) is a rare but well-documented cause of paralysis, often occurring after infection. Few cases have been reported in association with spinal cord injury (SCI), which masks the characteristic ascending paralysis. To our knowledge, this is the first reported case of confirmed GBS during the clinical course of thoracic paraplegia due to a gunshot wound (GSW). Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.054DOI Listing

Combined achalasia and cricopharyngeal achalasia in a patient with type 1 myotonic dystrophy: a case report.

Gastroenterol Hepatol Bed Bench 2020 ;13(2):181-183

Department of Gastroenterology, University of Toledo Medical Center, Toledo, Ohio, USA.

Type 1 myotonic dystrophy (MD) is a rare inherited disease which presents with skeletal muscle weakness and myotonia. Involvement of smooth muscles is also common and mainly manifests in the gastrointestinal tract. We report a case of type 1 MD who presented with dysphagia and was found to have unique esophageal manometry findings. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149813PMC
January 2020

Receptor-Binding Assays of Enterovirus D68.

Methods Mol Biol 2020 ;2132:629-639

Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

Human enterovirus D68 (EV-D68) is a causative agent for acute respiratory infections and potentially central nervous system illnesses with increasing epidemiological significance. Recent studies have highlighted the role of sialic acids as a functional receptor for EV-D68 in vitro. However, further investigations are required to reveal its significance in actual infections in human. Read More

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http://dx.doi.org/10.1007/978-1-0716-0430-4_54DOI Listing
January 2020

Comparison of abdominal compression devices in persons with abdominal paralysis due to spinal cord injury.

Spinal Cord Ser Cases 2019 04 16;5(1):35. Epub 2019 Apr 16.

University of Puget Sound, 1500 N Warner St. CMB 1030, 98416, Tacoma, WA, USA.

Study Design: Single subject design with five subjects.

Objectives: The objetive of this study is to compare the effectiveness and usability of alternative commercial abdominal compression garments with participants' usual medical binders.

Setting: Private residences in Pierce and King Counties, WA, USA. Read More

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http://dx.doi.org/10.1038/s41394-019-0176-xDOI Listing

Guillain-Barré syndrome in a heart transplantation recipient.

J Am Assoc Nurse Pract 2020 Apr 8. Epub 2020 Apr 8.

Department of Heart center, Cheng-Hsin General Hospital, Taipei, Taiwan.

A rare case of a heart transplantation recipient with Guillain-Barré syndrome occurred, which was associated with peripheral nervous system damage. Based on a review of epidemiological research, the symptom development process, and diagnostic tools, the authors highlight the extreme rarity of this postinfectious immune disease. After diagnosis, plasma exchange and immunoregulatory therapy should be performed because they result in rapid recovery. Read More

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http://dx.doi.org/10.1097/JXX.0000000000000400DOI Listing

[Rhabdomyolysis: have you considered food poisoning from quails?]

Authors:
Carlo Basile

G Ital Nefrol 2020 Apr 9;37(2). Epub 2020 Apr 9.

Divisione di Nefrologia, Ospedale Miulli, Acquaviva delle Fonti, Bari, Italia; Associazione Nefrologica Gabriella Sebastio, Martina Franca, Taranto, Italia.

Rhabdomyolysis (R) is a complex condition involving the rapid dissolution of damaged or injured skeletal muscle. This leads to the direct release of intracellular components, including myoglobin, creatine kinase, aldolase, and lactate dehydrogenase, as well as electrolytes, into the bloodstream and extracellular space. Clinically, R shows a triad of symptoms: myalgia, limb weakness, and myoglobinuria without hematuria, while myoglobin has been recognized as playing a part in the development of acute kidney injury. Read More

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Diaphragm paralysis: a case report.

Multidiscip Respir Med 2020 Jan 18;15(1):415. Epub 2020 Mar 18.

Department of Clinical and Molecular Medicine, Division of Respiratory Diseases, Umberto I Hospital, Sapienza University, Rome.

Introduction: Bilateral paralysis of the diaphragm may be an idiopathic clinical condition or associated with several diseases such as trauma, surgery, viral infections, neurologic disorders. The diaphragm is the main respiratory muscle. It is a cupoliform muscle-tendon structure, innervated bilaterally by phrenic nerve, which originates from C3-C5 nerve roots. Read More

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http://dx.doi.org/10.4081/mrm.2020.415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137759PMC
January 2020

A descriptive study of ciguatera fish poisoning in Cook Islands dogs and cats: Exposure history, clinical signs, and formulation of a case definition.

Vet World 2020 Feb 27;13(2):372-385. Epub 2020 Feb 27.

EpiCentre, School of Veterinary Science, Massey University, Palmerston North, New Zealand.

Background And Aim: Ciguatera fish poisoning (CFP) is a multisystem toxicosis caused by the ingestion of warm water marine species. Dogs and cats are susceptible to CFP, but there is little published and much unknown about the condition in these species. This study aims to describe the syndrome of CFP in dogs and cats and to develop a case definition. Read More

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http://dx.doi.org/10.14202/vetworld.2020.372-385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096299PMC
February 2020