5,594 results match your criteria Diaphragmatic Paralysis


Bilateral Diaphragmatic Paralysis: A Rare but not to be Neglected Cause of Dyspnea.

Isr Med Assoc J 2019 Feb;21(2):126-129

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Israel.

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February 2019

Maternal respiratory distress and successful reversal with sugammadex during intrauterine transfusion with fetal paralysis.

Int J Obstet Anesth 2019 Jan 8. Epub 2019 Jan 8.

Department of Obstetrics and Gynaecology, IWK Health Centre, Halifax, Nova Scotia, Canada.

A 70 kg, 34-year-old woman at 29 weeks-of-gestation required intrauterine transfusion for Rh (D) alloimmunization. In the ambulatory treatment clinic, 19 mg of rocuronium was administered intramuscularly in split doses into the fetal buttock. The fetus moved and inadvertent maternal neuromuscular blockade occurred, leading to respiratory distress. Read More

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http://dx.doi.org/10.1016/j.ijoa.2019.01.002DOI Listing
January 2019

A case of stapled resection of redundant diaphragm and early evisceration of gastrointestinal content.

Wideochir Inne Tech Maloinwazyjne 2019 Jan 7;14(1):141-144. Epub 2018 Aug 7.

Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.

Diaphragm paralysis has been observed following cervical spinal cord and diaphragm injuries. Patients with diaphragm paralysis require plication of the diaphragm if significant pulmonary dysfunction occurs. We aimed to report the unsuccessful stapling technique in the correction of diaphragm paralysis. Read More

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http://dx.doi.org/10.5114/wiitm.2018.77543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372874PMC
January 2019

An increase in reports of acute flaccid paralysis (AFP) in the United Kingdom, 1 January 2018-21 January 2019: early findings.

Euro Surveill 2019 Feb;24(6)

Members of the UK AFP task force are listed at the end of the article.

During 2018, the United Kingdom experienced an increase in reports of cases of acute flaccid paralysis (AFP). As at 21 January 2019, 40 cases had been identified with a peak in October 2018. The increase was temporally associated with an upsurge in enterovirus (EV) D68 activity. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.6.1900093DOI Listing
February 2019

RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43.

J Mol Biol 2019 Feb 8. Epub 2019 Feb 8.

UK Dementia Research Institute at King's College London, London, SE5 9RT, United Kingdom; The Wohl Institute at King's College London, London, SE5 9RT, United Kingdom; Department of Medicina Molecolare, University of Pavia, Pavia, 27100, Italy. Electronic address:

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTD) are incurable motor neuron diseases associated with muscle weakness, paralysis and respiratory failure. Accumulation of TAR DNA-binding protein 43 (TDP-43) as toxic cytoplasmic inclusions is one of the hallmarks of these pathologies. TDP-43 is an RNA-binding protein responsible for regulating RNA transcription, splicing, transport and translation. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.01.028DOI Listing
February 2019
2 Reads

Isolated vocal cord paralysis in two siblings with compound heterozygous variants in MUSK: Expanding the phenotypic spectrum.

Am J Med Genet A 2019 Feb 4. Epub 2019 Feb 4.

Department of Pediatrics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

The congenital myasthenic syndromes (CMS) are a heterogeneous group of disorders caused by perturbations in signal transduction at the neuromuscular junction. Defects in muscle, skeletal, receptor tyrosine kinase (MuSK) cause two distinct phenotypes: fetal akinesia with multiple congenital anomalies (Fetal akinesia deformation sequence [MIM:208150]) and early onset congenital myasthenia (myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency [MIM:616325]). Myasthenia due to MuSK deficiency has variable clinical features, ranging from a milder presentation of isolated late-onset proximal muscle weakness; to a severe presentation of prenatal-onset diffuse weakness, ophthalmoplegia, respiratory failure, and vocal cord paralysis (VCP). Read More

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http://dx.doi.org/10.1002/ajmg.a.61060DOI Listing
February 2019

Non-aneurysmal Subarachnoid Hemorrhaging: A Rare Cause of Death in a Patient with Multiple System Atrophy.

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Neurology, Kyoto University Graduate School of Medicine, Japan.

Sudden death as a result of multiple system atrophy (MSA) is usually attributed to vocal cord paralysis or disruption of breathing owing to the degeneration of the brainstem respiratory centers. However, the exact pathophysiology of sudden death is still unclear. In addition, specific causes of sudden death are not always investigated by an autopsy. Read More

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http://dx.doi.org/10.2169/internalmedicine.1567-18DOI Listing
February 2019
2 Reads

[Bilateral diaphragmatic palsy due to Lyme neuroborreliosis].

Rev Mal Respir 2019 Jan 30. Epub 2019 Jan 30.

Service des maladies respiratoires, hôpital Haut-Lévêque, centre hospitalier universitaire de Bordeaux, 33600 Pessac, France.

Introduction: Lyme disease is not uncommon and can sometimes progress to neurological complications. We report here an unusual case of bilateral diaphragmatic paralysis secondary to Lyme neuroborreliosis.

Case Report: A 79-year-old man was admitted to the intensive care unit for acute respiratory distress requiring intubation and the long-term use of nocturnal non-invasive ventilation. Read More

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http://dx.doi.org/10.1016/j.rmr.2018.07.008DOI Listing
January 2019
1 Read

Evaluation of upper oesophageal sphincter in unilateral vocal fold paralysis.

J Laryngol Otol 2019 Feb 1:1-6. Epub 2019 Feb 1.

Department of Otolaryngology,Selcuk University Medical Faculty Hospital,Konya,Turkey.

Objective: To evaluate dysphagia and manometric changes in the upper oesophageal sphincter in patients with unilateral vocal fold paralysis.

Methods: Thirty patients with unilateral vocal fold paralysis due to vagal nerve paralysis scheduled for evaluation were enrolled in the study group; 24 healthy subjects were included in the control group. Upper oesophageal sphincter basal and residual pressure, relaxation time, and pharyngeal pressure values were evaluated by manometry. Read More

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http://dx.doi.org/10.1017/S0022215119000045DOI Listing
February 2019
2 Reads

Prospective Hospital-Based Clinical and Electrophysiological Evaluation of Acute Organophosphate Poisoning.

Ann Indian Acad Neurol 2019 Jan-Mar;22(1):91-95

Department of Medicine, Jawaharlal Nehru Medical College and KLES Dr. Prabhakar Kore Hospital and MRC, Belagavi, Karnataka, India.

Introduction: Acute organophosphate (OP) poisoning is one of the most common poisoning causing significant morbidity and mortality in developing countries. Acute cholinergic manifestations predominate with many patients requiring intensive care management and ventilator support. Nerve conduction studies including repetitive nerve stimulation can evaluate the altered neuromuscular transmission and peripheral nerve function by OPs. Read More

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http://dx.doi.org/10.4103/aian.AIAN_137_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327708PMC
January 2019
1 Read

[A case of periodic thyrotoxic paralysis].

Authors:
G Kisoka X Bertrand

Rev Med Liege 2019 Jan;74(1):20-22

Département des Urgences, CHR Citadelle, Liège, Belgique.

Periodic thyrotoxic paralysis (TPP) is a disease that usually affects Asian men from 20 to 50 years. It is secondary to genetic mutations of ion channels for the transport of sodium and potassium. It is characterized by recurrent and brutal bouts of paresis / flaccid paralysis, without sensory involvement, in a context of hyperthyroidism. Read More

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January 2019
4 Reads

[Key technology of lymph node dissection along recurrent laryngeal nerve and its associated complication prevention in patients with thoracic esophageal cancer].

Zhonghua Zhong Liu Za Zhi 2019 Jan;41(1):1-5

Department of Thoracic Surgery, National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.

Esophageal cancer is one of the most prevalent cancers in China. Lymph node metastasis is one of the most important prognostic factors and severely affect the long-term survival after surgical treatment. Therefore, systemic two-field lymph node dissection including thoracic and abdominal draining nodes of the esophagus during surgery is essential in order to improve the long-term survival for the patients with thoracic esophageal cancer, and it is also the basis for precise staging and postoperative adjuvant treatment regimen- making. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.01.001DOI Listing
January 2019
1 Read

Persistent diaphragmatic paralysis associated with interscalene nerve block after total shoulder arthroplasty: a case report.

JSES Open Access 2018 Oct 22;2(3):165-168. Epub 2018 Jun 22.

Division of Sports Medicine & Shoulder Surgery, Department of Orthopaedic Surgery, Midwest Orthopaedics at Rush, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.jses.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334858PMC
October 2018
1 Read

Atypical Clinical Presentations of Pediatric Acute Immune-Mediated Polyneuropathy.

J Child Neurol 2019 Jan 23:883073818825213. Epub 2019 Jan 23.

2 Institute of Child Neurology, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.

Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis in children. During the acute phase, the disorder can be life-threatening by involving the respiratory muscles and the autonomic nervous system. Nevertheless, the prognosis is good, and most children achieve full recovery. Read More

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http://journals.sagepub.com/doi/10.1177/0883073818825213
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http://dx.doi.org/10.1177/0883073818825213DOI Listing
January 2019
5 Reads

Genomic Analyses of Acute Flaccid Myelitis Cases among a Cluster in Arizona Provide Further Evidence of Enterovirus D68 Role.

MBio 2019 Jan 22;10(1). Epub 2019 Jan 22.

Pathogen and Microbiome Division, Translational Genomics Research Institute, Flagstaff, Arizona, USA

Enteroviruses are a common cause of respiratory and gastrointestinal illness, and multiple subtypes, including poliovirus, can cause neurologic disease. In recent years, enterovirus D68 (EV-D68) has been associated with serious neurologic illnesses, including acute flaccid myelitis (AFM), frequently preceded by respiratory disease. A cluster of 11 suspect cases of pediatric AFM was identified in September 2016 in Phoenix, AZ. Read More

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http://dx.doi.org/10.1128/mBio.02262-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343034PMC
January 2019
4 Reads

Acute flaccid myelitis caused by enterovirus D68: Case definitions for use in clinical practice.

Eur J Paediatr Neurol 2019 Jan 11. Epub 2019 Jan 11.

Paediatric Neurosciences, Royal Hospital for Sick Children, Edinburgh, UK; Child Life and Health, University of Edinburgh, Edinburgh, UK.

Acute flaccid myelitis (AFM) was increasingly detected in recent years, coinciding with upsurges of enterovirus D68 (EV-D68) infections. We reviewed the evidence for a causal relationship between both. Based on reported cases, we provide case definitions for AFM caused by EV-D68 infections to enable a standard procedure for affected patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10903798183028
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http://dx.doi.org/10.1016/j.ejpn.2019.01.001DOI Listing
January 2019
5 Reads

Recurrent bacterial pneumonia in Irish Wolfhounds: Clinical findings and etiological studies.

J Vet Intern Med 2019 Jan 21. Epub 2019 Jan 21.

Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.

Background: Increased incidence of bacterial pneumonia (BP) has been reported in Irish Wolfhounds (IWHs), and recurrence of BP is common. The etiology of recurrent pneumonia in IWHs is largely unknown.

Objectives: To describe clinical findings in IWHs with recurrent BP and investigate possible etiologies. Read More

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http://dx.doi.org/10.1111/jvim.15413DOI Listing
January 2019
1 Read

Risk factors and outcomes of vocal cord paralysis after lung transplantation - a retrospective cohort study.

Transpl Int 2019 Jan 21. Epub 2019 Jan 21.

Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.

Vocal cord paralysis (VCP) may complicate thoracic surgery and is associated with increased morbidity and mortality. Among lung transplant (LTx) recipients, chronic pulmonary aspiration can contribute to chronic allograft dysfunction (CLAD). We herein assessed the unknown incidence and clinical impact of VCP in a large LTx cohort. Read More

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http://dx.doi.org/10.1111/tri.13402DOI Listing
January 2019
3 Reads

Neurotoxic envenomation by the South African coral snake (Aspidelaps lubricus): A case report.

Toxicon 2019 Mar 17;159:38-40. Epub 2019 Jan 17.

Division of Medical Toxicology, Department of Emergency Medicine, University of Pittsburgh School of Medicine, Iroquois Building Suite 400, 3600 Forbes Ave, Pittsburgh, PA 15213, USA. Electronic address:

The South African coral snake (Aspidelaps lubricus, Elapidae) has not previously been reported to cause any neurotoxic envenomations in humans. We recently treated a 44-year-old man who was bitten twice, once in each hand, by a captive South African coral snake (Aspidelaps lubricus) while feeding the female snake who had recently laid eggs. Approximately one hour after receiving the bite, he developed vomiting, respiratory failure requiring mechanical ventilation, and paralysis of the bulbar and upper extremity muscles, with retention of voluntary motor control in the lower extremities. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00410101193001
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http://dx.doi.org/10.1016/j.toxicon.2019.01.001DOI Listing
March 2019
9 Reads

Effect of local anesthetic volume (20 mL vs 30 mL ropivacaine) on electromyography of the diaphragm and pulmonary function after ultrasound-guided supraclavicular brachial plexus block: a randomized controlled trial.

Reg Anesth Pain Med 2019 Jan;44(1):69-75

Department of Anesthesiology, The 98th Clinical College of PLA, Anhui Medical University, Huzhou, China

Background And Objectives: Diaphragmatic paralysis following supraclavicular brachial plexus block (SCBPB) is ascribed to phrenic nerve palsy. This study investigated the effect of 2 volumes of 0.375% ropivacaine on efficacy of block as a surgical anesthetic and as an analgesic and examined diaphragm compound muscle action potentials (CMAPs) and pulmonary function before and after SCBPB. Read More

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http://dx.doi.org/10.1136/rapm-2018-000014DOI Listing
January 2019
2 Reads

How Different is AMAN from AIDP in Childhood GBS? A Prospective Study from North India.

Indian J Pediatr 2019 Jan 12. Epub 2019 Jan 12.

Pediatric Neurology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Objectives: To compare the clinical profile and short-term outcome of children with axonal and demyelinating subtypes of childhood Guillain Barré syndrome (GBS).

Methods: This is a prospective observational study conducted in a tertiary care teaching hospital in North India. Consecutive children with Guillain Barré syndrome were recruited to compare the clinical profile and short term outcome among the subtypes. Read More

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http://dx.doi.org/10.1007/s12098-018-2835-5DOI Listing
January 2019
1 Read
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Anti-mitochondria antibody-related tubulointerstitial nephritis accompanied by severe hypokalemic paralysis.

CEN Case Rep 2019 Jan 14. Epub 2019 Jan 14.

Department of Nephrology, Osaka Rosai Hospital, 1179-3 Nagasone-cho, Sakai City, Osaka, 591-8025, Japan.

A 47-year-old man presented with severe hypokalemic paralysis and respiratory failure. A large amount of potassium was administered along with providing intensive care, and his condition improved. Hypokalemia was attributed to increased urinary potassium excretion. Read More

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http://dx.doi.org/10.1007/s13730-019-00376-6DOI Listing
January 2019
1 Read

MicroRNAs as regulators of cell death mechanisms in amyotrophic lateral sclerosis.

J Cell Mol Med 2019 Mar 4;23(3):1647-1656. Epub 2019 Jan 4.

Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), Neurology Unit, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting upper and lower motor neurons (MNs), resulting in paralysis and precocious death from respiratory failure. Although the causes of ALS are incompletely understood, the role of alterations in RNA metabolism seems central. MicroRNAs (miRNAs) are noncoding RNAs implicated in the regulation of gene expression of many relevant physiological processes, including cell death. Read More

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http://dx.doi.org/10.1111/jcmm.13976DOI Listing
March 2019
1 Read

Cryoballoon ablation of atrial fibrillation is effectively feasible without previous imaging of pulmonary vein anatomy: insights from the 1STOP project.

J Interv Card Electrophysiol 2019 Jan 3. Epub 2019 Jan 3.

Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino IRCCS Milan Azienda, Milan, Italy.

Background: Pulmonary vein isolation by cryoablation (PVI-C) is a standard therapy for the treatment of atrial fibrillation (AF); however, PVI-C can become a challenging procedure due to the anatomy of the left atrium and pulmonary veins (PVs). Importantly, the utility of imaging before the procedure is still unknown regarding the long-term clinical outcomes following PVI-C. The aim of the analysis is to evaluate the impact of imaging before PVI-C on procedural data and AF recurrence. Read More

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http://dx.doi.org/10.1007/s10840-018-0500-6DOI Listing
January 2019
3 Reads

Conium maculatum intoxication: Literature review and case report on hemlock poisoning.

Forensic Sci Rev 2019 Jan;31(1):23-36

Laboratory of Forensic Sciences, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.

The aim of this paper is to highlight the symptomatology in three Conium maculatum intoxication incidents, one of which was fatal. A number of studies were reviewed in order to update and summarize the relevant literature on the incidence, sociodemographic variables, method of poisoning, pathophysiology, diagnosis, variables associated with survival and fatality, management, and treatment of C. maculatum intoxication as well as the biosynthesis and biological effects of poison hemlock alkaloids. Read More

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January 2019
2 Reads

Pulmonary inflammatory myofibroblastic tumour and IgG-related disease presenting with lower limb paralysis.

Thorax 2019 Mar 22;74(3):313-314. Epub 2018 Dec 22.

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

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http://dx.doi.org/10.1136/thoraxjnl-2018-212692DOI Listing
March 2019
2 Reads

Tilting the balance: hemidiaphragm paralysis leading to right to left cardiac shunt.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Internal Medicine, Abington Hospital - Jefferson Health, Abington, Pennsylvania, USA.

Patent foramen ovale (PFO) is a congenital abnormality present in 25%-30% of healthy adults and rarely leads to any sequelae. It is associated with a left-to-right shunt which usually does not lead to any haemodynamic compromise. Occasionally, the shunt can get reversed; that is, right-to-left shunt occurs due to worsening pulmonary hypertension and can lead to persistent hypoxia. Read More

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http://www.bmj.com/lookup/doi/10.1136/bcr-2018-227944
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http://dx.doi.org/10.1136/bcr-2018-227944DOI Listing
December 2018
13 Reads

Isolated Recovery of Adductor Muscle Function Following Bilateral Recurrent Laryngeal Nerve Injuries.

Laryngoscope 2018 Dec 13. Epub 2018 Dec 13.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Szeged, Szeged, Hungary.

Objectives/hypothesis: The aim of this study was to analyze the phoniatric and respiratory outcomes of a subset of bilateral vocal cord paralysis (BVCP) patients who were all treated with unilateral endoscopic arytenoid abduction lateropexy (EAAL). EAAL is a nondestructive, minimally invasive glottis widening operation, which does not damage either the surgically treated or the contralateral vocal cord. Therefore, it does not impair the regeneration potential of the recurrent laryngeal nerve. Read More

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http://dx.doi.org/10.1002/lary.27718DOI Listing
December 2018
2 Reads

«Snake eye» and «pencil-like» signs together with diaphragmatic paralysis in a patient with anterior spinal cord ischemia.

Med Intensiva 2018 Dec 10. Epub 2018 Dec 10.

Servicio de Medicina Intensiva, Hospital General Universitario de Elche, Elche, Alicante, España.

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http://dx.doi.org/10.1016/j.medin.2018.11.002DOI Listing
December 2018

Respiratory failure requiring mechanical ventilation in critically ill adults in Ghana: A prospective observational study.

Afr J Emerg Med 2018 Dec 20;8(4):155-157. Epub 2018 Sep 20.

Department of Emergency Medicine, University of Florida, Gainesville, FL, USA.

Introduction: Respiratory failure is commonly seen in African emergency centres and intensive care units, but little is known about the need for intubation and mechanical ventilation.

Methods: From April to October 2017, we recorded the number of patients intubated and ventilated in the emergency centre and intensive care unit at Komfo Anokye Teaching Hospital in Kumasi, Ghana on a daily basis. We assessed patients for presence of acute respiratory distress syndrome (ARDS) using the Kigali Modification of the Berlin ARDS criteria. Read More

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http://dx.doi.org/10.1016/j.afjem.2018.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277501PMC
December 2018
3 Reads

Surveillance of enteroviruses from paediatric patients attended at a tertiary hospital in Catalonia from 2014 to 2017.

J Clin Virol 2019 Jan 30;110:29-35. Epub 2018 Nov 30.

Respiratory Viruses Unit, Virology Section, Microbiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: Enterovirus (EV) infections are usually asymptomatic or mild, but symptomatic infections can evolve to severe complications. Outbreaks of EV-A71 and EV-D68 have been recently reported worldwide, sometimes related to severe clinical outcomes.

Objective: To describe EV genetic diversity and the clinical outcomes from paediatric patients attended at a tertiary university hospital in Barcelona (Catalonia, Spain) from 2014 to 2017. Read More

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http://dx.doi.org/10.1016/j.jcv.2018.11.004DOI Listing
January 2019
3 Reads

An Unusual Case of Cardiac Tamponade Secondary to an Elevated Right Hemidiaphragm.

Can J Cardiol 2018 Dec 19;34(12):1688.e21-1688.e23. Epub 2018 Oct 19.

Northern Ontario School of Medicine, Health Sciences North, Sudbury, Ontario, Canada. Electronic address:

Diaphragmatic eventration in old age is a rare phenomenon. Typically, it is thought to originate as a result of failure of development of the muscles of the diaphragm. Less commonly, it can occur secondary to acquired conditions resulting from spinal cord or phrenic nerve injury and is only detected incidentally when the patient presents with dyspnea, chest infection, or cardiac compression symptoms. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.10.008DOI Listing
December 2018
2 Reads

Anterior mediastinal masses - A multidisciplinary pathway for safe diagnostic procedures.

J Pediatr Surg 2018 Nov 6. Epub 2018 Nov 6.

Department of Paediatric Surgery, St Georges Hospital NHS Trust, London, UK. Electronic address:

Objective: The objective of this study was to report our multidisciplinary diagnostic approach for patients with anterior mediastinal masses (AMM).

Methods: A retrospective review of patients with AMM at a tertiary pediatric surgical oncology centre (January 2011-December 2016) was performed. We analyzed data on clinical presentation, mode of tissue diagnosis, anesthetic techniques, and complications. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223468183074
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http://dx.doi.org/10.1016/j.jpedsurg.2018.10.080DOI Listing
November 2018
11 Reads

Diaphragmatic dysfunction.

Pulmonology 2018 Nov 30. Epub 2018 Nov 30.

Pneumology Service, University Hospital Complex of Santiago, Santiago de Compostela, Spain; Interdisciplinary Research Group in Pulmonology, Institute of Sanitary Research of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.

The diaphragm is the main breathing muscle and contraction of the diaphragm is vital for ventilation so any disease that interferes with diaphragmatic innervation, contractile muscle function, or mechanical coupling to the chest wall can cause diaphragm dysfunction. Diaphragm dysfunction is associated with dyspnoea, intolerance to exercise, sleep disturbances, hypersomnia, with a potential impact on survival. Diagnosis of diaphragm dysfunction is based on static and dynamic imaging tests (especially ultrasound) and pulmonary function and phrenic nerve stimulation tests. Read More

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http://dx.doi.org/10.1016/j.pulmoe.2018.10.008DOI Listing
November 2018
2 Reads

A neonatal mouse model of Enterovirus D68 infection induces both interstitial pneumonia and acute flaccid myelitis.

Antiviral Res 2019 Jan 29;161:108-115. Epub 2018 Nov 29.

National Institute for Food and Drug Control, Beijing, China. Electronic address:

Enterovirus D68 (EV-D68) is a causative agent of recent outbreaks of severe respiratory illness, pneumonia and acute flaccid myelitis (AFM) worldwide. The study of the pathogenesis, vaccines and anti-viral drugs for EV-D68 infection has been reported. Given the previously described mouse model of EV-D68, we sought to establish a neonatal mice model inducing both pneumonia and AFM. Read More

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http://dx.doi.org/10.1016/j.antiviral.2018.11.013DOI Listing
January 2019
9 Reads

Rapid and robust restoration of breathing long after spinal cord injury.

Nat Commun 2018 11 27;9(1):4843. Epub 2018 Nov 27.

Department of Neurosciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.

There exists an abundance of barriers that hinder functional recovery following spinal cord injury, especially at chronic stages. Here, we examine the rescue of breathing up to 1.5 years following cervical hemisection in the rat. Read More

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http://www.nature.com/articles/s41467-018-06937-0
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http://dx.doi.org/10.1038/s41467-018-06937-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258702PMC
November 2018
9 Reads

Sudden onset of lower limb flaccid paralysis.

Arch Dis Child Educ Pract Ed 2018 Nov 26. Epub 2018 Nov 26.

Department of Paediatrics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

A previously well 15-year-old boy presented to the emergency department with sudden-onset severe back pain and inability to weight bear. Preceding this event, he stretched out in bed and felt a click in his back.On examination, he was alert and interactive with normal vital signs. Read More

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http://dx.doi.org/10.1136/archdischild-2018-315903DOI Listing
November 2018
2 Reads

Spontaneous spinal epidural hematoma mimicking Guillain-Barre Syndrome.

Brain Dev 2018 Nov 21. Epub 2018 Nov 21.

Department of Neurology, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.

Background: The initial symptoms of Guillain-Barre Syndrome (GBS) can be similar to a case of spontaneous spinal epidural hematoma (SSEH) located at the cervicothoracic junction. Therefore, SSEH may be misdiagnosed as GBS.

Case Report: A previously healthy 6-year-old girl presented with a 2-day history of progressive pain in the lower extremities and an inability to walk. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03877604183054
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http://dx.doi.org/10.1016/j.braindev.2018.11.004DOI Listing
November 2018
10 Reads

Bilateral Vocal Cord Paralysis: Pembrolizumab-Induced Delayed-Onset Toxicity in a Patient with Lung Adenocarcinoma.

J Thorac Oncol 2018 Dec;13(12):e257-e259

Department of Respiratory Medicine, Hikone Municipal Hospital, Hikone, Japan.

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http://dx.doi.org/10.1016/j.jtho.2018.08.2032DOI Listing
December 2018
1 Read

Delayed Recurrent Laryngeal Nerve Palsy Following Anterior Cervical Discectomy and Fusion.

World Neurosurg 2019 Feb 19;122:380-383. Epub 2018 Nov 19.

Department of Neurological Surgery, UCSF Medical Center, University of California, San Francisco, San Francisco, California, USA. Electronic address:

Background: Vocal cord dysfunction resulting from recurrent laryngeal nerve palsy (RLNP) is a known complication following anterior cervical discectomy and fusion. RLNP occurs typically secondary to neurapraxia caused by intraoperative compression or traction on the nerve and less commonly from direct nerve injury intraoperatively in the setting of anterior cervical spine surgery. Patients with RLNP typically present with hoarseness immediately after surgery owing to unilateral vocal cord paralysis. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.066DOI Listing
February 2019
25 Reads

Somatotopy of corticospinal tract fibres of the intercostal muscles: report of a case and review of literature.

Brain Struct Funct 2018 Nov 20. Epub 2018 Nov 20.

Department of Neurosurgery, King's College Hospital NHS Foundation Trust, London, UK.

This study aimed at describing the first case of subcortical stimulation of the corticospinal tract leading to selective contraction of the intercostal muscles during surgery for removal of a tumour centred in the right central lobule/supplementary motor area. A 53-year-old male presented with partial motor seizures. Imaging demonstrated a low-grade glioma affecting the posterior aspect of the superior and middle frontal gyri and invading the precentral gyrus. Read More

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http://dx.doi.org/10.1007/s00429-018-1796-9DOI Listing
November 2018
10 Reads

Pharmacoinformatic Approach to Explore the Antidote Potential of Phytochemicals on Bungarotoxin from Indian Krait, .

Comput Struct Biotechnol J 2018 31;16:450-461. Epub 2018 Oct 31.

Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau.

Venomous reptiles especially serpents are well known for their adverse effects after accidental conflicts with humans. Upon biting humans these serpents transmit arrays of detrimental toxins with diverse physiological activities that may either lead to minor symptoms such as dermatitis and allergic response or highly severe symptoms such as blood coagulation, disseminated intravascular coagulation, tissue injury, and hemorrhage. Other complications like respiratory arrest and necrosis may also occur. Read More

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http://dx.doi.org/10.1016/j.csbj.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231056PMC
October 2018
8 Reads

A retrospective analysis of clinical characteristics of childhood narcolepsy.

Paediatr Child Health 2018 Sep 5;23(6):e95-e101. Epub 2018 Mar 5.

Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Ontario.

Aim: Narcolepsy, encompassing excessive daytime sleepiness (EDS), cataplexy, sleep paralysis and hypnogogic hallucinations, was previously considered rare in childhood. Recently, cases of childhood narcolepsy have increased significantly and the reasons for this may include the increasing awareness of narcolepsy as well as the H1N1 vaccination. The aim of this study was to describe the clinical characteristics of childhood narcolepsy, specifically focusing on cataplexy subtypes that may facilitate early recognition of narcolepsy. Read More

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http://dx.doi.org/10.1093/pch/pxx205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234419PMC
September 2018
8 Reads
1.545 Impact Factor

[Clinical evaluation of vocal fold paralysis in 207 children].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Nov;53(11):847-850

Department of Otorhinolaryngology Head and Neck Surgery, Children's Hospital of Fudan University, Shanghai 201102, China.

To investigate the etiology and clinical characteristics of vocal fold paralysis in children. To provide useful information for diagnosis, management and prognosis in the clinical work. Two hundred and seven children with vocal fold paralysis in Children's Hospital of Fudan University were retrospectively studied, and followed-up. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2018.11.010DOI Listing
November 2018
7 Reads

A Rapid, Sensitive, and Portable Biosensor Assay for the Detection of Botulinum Neurotoxin Serotype A in Complex Food Matrices.

Toxins (Basel) 2018 Nov 15;10(11). Epub 2018 Nov 15.

Foodborne Toxin Detection and Prevention Research Unit, Western Regional Research Center, Agricultural Research Services, United States Department of Agriculture, 800 Buchanan Street, Albany, CA 94710, USA.

Botulinum neurotoxin (BoNT) intoxication can lead to the disease botulism, characterized by flaccid muscle paralysis that can cause respiratory failure and death. Due to the significant morbidity and mortality costs associated with BoNTs high toxicity, developing highly sensitive, rapid, and field-deployable assays are critically important to protect the nation's food supply against either accidental or intentional contamination. We report here that the B-cell based biosensor assay CANARY (Cellular Analysis and Notification of Antigen Risks and Yields) Zephyr detects BoNT/A holotoxin at limits of detection (LOD) of 10. Read More

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http://dx.doi.org/10.3390/toxins10110476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266793PMC
November 2018
2 Reads

Thyrotoxic periodic paralysis complicated by life-threatening acute hypercapnic respiratory failure in a Chinese male with painless thyroiditis.

Am J Emerg Med 2019 Feb 7;37(2):379.e1-379.e3. Epub 2018 Nov 7.

Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, Wenzhou 325027, China. Electronic address:

Context: Thyrotoxic periodic paralysis (TPP) is a relatively common complication seen in Asian hyperthyroid patients. However, it is a rare occurrence to find a TPP case comprised of acute hypercapnic respiratory failure in patients with painless thyroiditis.

Patient: A 29-year-old Chinese man presented with flaccid paralysis of all four limbs and he was brought to emergency room. Read More

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http://dx.doi.org/10.1016/j.ajem.2018.11.010DOI Listing
February 2019
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Endoscopic lateralization of the vocal fold.

Eur Ann Otorhinolaryngol Head Neck Dis 2018 Nov 9. Epub 2018 Nov 9.

Clinique universitaire d'ORL et chirurgie cervico-faciale, hôpital Nord Michallon, CHU de Grenoble, CS 10217, 38043 Grenoble cedex 9, France; Faculté de médecine, université Grenoble Alpes, Domaine de la Merci, BP 170, 38042 Grenoble cedex 9, France; UGA, UMR, CNRS 5309, Inserm 1209, institut pour l'avancée des Biosciences, site Santé, Allée des Alpes, 38700 La Tronche, France; Division of Otolaryngology, Department of Surgery, University of Alabama at Birmingham, Alabama, USA. Electronic address:

Vocal fold paralysis in adduction can result in significant breathing difficulties. Techniques such as vocal fold lateralization and/or arytenoidopexy help to improve respiratory function in this setting. These techniques require open approach or specific instruments. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18797296183017
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http://dx.doi.org/10.1016/j.anorl.2018.10.014DOI Listing
November 2018
10 Reads