6,750 results match your criteria Diaphragmatic Hernias Congenital


The proportion of alveolar type 1 cells decreases in murine hypoplastic congenital diaphragmatic hernia lungs.

PLoS One 2019 17;14(4):e0214793. Epub 2019 Apr 17.

Department of Development and Regeneration, Division Organ Systems, KU Leuven, Leuven, Belgium.

Background: Pulmonary hypoplasia, characterized by incomplete alveolar development, remains a major cause of mortality and morbidity in congenital diaphragmatic hernia. Recently demonstrated to differentiate from a common bipotent progenitor during development, the two cell types that line the alveoli type 1 and type 2 alveolar cells have shown to alter their relative ratio in congenital diaphragmatic hernia lungs.

Objective: We used the nitrofen/bisdiamine mouse model to induce congenital diaphragmatic hernia and accurately assess the status of alveolar epithelial cell differentiation in relation to the common bipotent progenitors. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214793PLOS

Lactation Experience of Mothers and Feeding Outcomes of Infants with Congenital Diaphragmatic Hernia.

Breastfeed Med 2019 Apr 16. Epub 2019 Apr 16.

5 Department of Neonatology, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Objective: This study explores the congenital diaphragmatic hernia (CDH) infant-mother dyad with regard to maternal lactation outcomes and infant exposure to a human milk diet.

Study Design: This was a retrospective descriptive cohort study conducted at Children's Hospital of Philadelphia. A total of 149 infants born with CDH and admitted to the Newborn/Infant Intensive Care Unit (N/IICU) were included in the study. Read More

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http://dx.doi.org/10.1089/bfm.2019.0011DOI Listing

Congenital sternal defect repair in an adult cat with incomplete pentalogy of Cantrell.

J Am Vet Med Assoc 2019 May;254(9):1099-1104

Case Description: A 1-year-old spayed female domestic shorthair cat was evaluated for a sternal defect and ventral abdominal wall hernia.

Clinical Findings: The cat appeared healthy. Palpation revealed a sternal defect, and the heart could be observed beating underneath the skin at the caudoventral aspect of the thorax. Read More

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http://dx.doi.org/10.2460/javma.254.9.1099DOI Listing
May 2019
2 Reads

MYRF haploinsufficiency causes 46,XY and 46,XX disorders of sex development: bioinformatics consideration.

Hum Mol Genet 2019 Apr 1. Epub 2019 Apr 1.

Department of Human Genetics.

Disorders of sex development (DSDs) are defined as congenital conditions in which chromosomal, gonadal or anatomical sex is atypical. In many DSD cases, genetic causes remain to be elucidated. Here, we performed a case-control exome sequencing study comparing gene-based burdens of rare damaging variants between 26 DSD cases and 2625 controls. Read More

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http://dx.doi.org/10.1093/hmg/ddz066DOI Listing

3D reconstruction of diaphragmatic defects in CDH: a fetal MRI study.

Ultrasound Obstet Gynecol 2019 Apr 15. Epub 2019 Apr 15.

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria.

Objectives: To assess the clinical feasibility and validity of fetal MRI-based 3D reconstructions to localize, classify, and quantify diaphragmatic defects in congenital diaphragmatic hernia (CDH).

Methods: Manual segmentation of the diaphragm based on 65 in vivo and four postmortem fetal MRI scans of 46 CDH cases (gestational age 16 - 38 gestational weeks (GW)) was performed using SSFP, T2-weighted, and T1-weighted sequences and ITK-Snap. The resultant 3D models of the fetal diaphragm and its defect(s) were validated by postmortem MRI segmentation in four cases and/or comparison to a reference classification based on autopsy and surgery reports. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/uog.20296
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http://dx.doi.org/10.1002/uog.20296DOI Listing
April 2019
2 Reads

Maternal Risk Factors and Perinatal Characteristics in Congenital Diaphragmatic Hernia: A Nationwide Population-Based Study.

Fetal Diagn Ther 2019 Apr 12:1-8. Epub 2019 Apr 12.

Department of Pediatric Surgery, Karolinska University Hospital, Stockholm, Sweden.

Background: The etiology of congenital diaphragmatic hernia (CDH) remains poorly understood. We hypothesize that environmental factors play an important role in the development of CDH.

Aim: The objective of this study was to investigate associated maternal risk factors in pregnancies with CDH. Read More

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http://dx.doi.org/10.1159/000497619DOI Listing
April 2019
1 Read

A multicenter study to predict neonatal survival according to lung-to-head ratio and liver herniation in fetuses with left Congenital Diaphragmatic Hernia (CDH): hidden mortality from the Latin American CDH Study Group Registry.

Prenat Diagn 2019 Apr 13. Epub 2019 Apr 13.

Unidad de Cirugía Fetal, Hospital de Especialidades del Niño y la Mujer, Queretaro, Mexico.

Objective: To evaluate natural history of fetuses congenital diaphragmatic hernia (CDH) prenatally diagnosed in countries where termination of pregnancy is not legally allowed and to predict neonatal survival according to lung area and liver herniation.

Methods: Prospective study including antenatally diagnosed CDH cases managed expectantly during pregnancy in six tertiary Latin American centres. The contribution of the observed/expected lung-to-head ratio (O/E-LHR) and liver herniation in predicting neonatal survival was assessed. Read More

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http://dx.doi.org/10.1002/pd.5458DOI Listing

Surgical technique for developing a rabbit model of congenital diaphragmatic hernia and tracheal occlusion.

MethodsX 2019 22;6:594-600. Epub 2019 Mar 22.

Division of Paediatric General Surgery, Children's Hospital London Health Science Centre, Schulich School of Medicine, Western University, London, ON, Canada.

The surgical model of congenital diaphragmatic hernia (CDH) has been utilized in exploring treatments and innovative therapies, such as tracheal occlusion (TO). The rabbit is an excellent surgical model compared to others due to lower cost, ease of care, short gestational period, and large litter size. This model is also ideal in studying lung hypoplasia of CDH because rabbit lung development is most similar to humans as alveolarization begins prior to birth and continues post-natally. Read More

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http://dx.doi.org/10.1016/j.mex.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441759PMC

Postnatal ultrasonography for evaluation of hernia sac of neonate with congenital diaphragmatic hernia.

Radiol Case Rep 2019 Jun 26;14(6):683-686. Epub 2019 Mar 26.

Department of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Congenital diaphragmatic hernia (CDH) is one of the most common major congenital anomalies. The presence of a hernia sac is associated with additional benefits in terms of improved neonatal survival. Here, we report a case of CDH with a hernia sac detected via postnatal ultrasonography. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439226PMC

Impact of maternal education on the outcome of newborns requiring surgery for congenital malformations.

PLoS One 2019 8;14(4):e0214967. Epub 2019 Apr 8.

Department of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.

Objective: Numerous studies established a link between socioeconomic status (SES) and several dimensions of general health. This study examines the association between maternal education as a widely used indicator of SES and outcome in newborns requiring surgical correction of congenital anomalies.

Methods: Ambispective data analysis of newborns with esophageal atresia (EA), intestinal atresia (IA), congenital diaphragmatic hernia (CDH), omphalocele (OC), gastroschisis (GS) undergoing surgery between 01/2008-11/2017 accessing the clinical databases Neodat and Viewpoint. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214967PLOS

Fetal echocardiography (ECHO) in assessment of structural heart defects in congenital diaphragmatic hernia patients: Is early postnatal ECHO necessary for ECMO candidacy?

J Pediatr Surg 2019 Feb 20. Epub 2019 Feb 20.

Texas Children's Fetal Center, Baylor College of Medicine, Texas Children's Hospital, Houston, TX; Michael E. DeBakey Department of Surgery-Division of Pediatric Surgery, Baylor College of Medicine, Texas Children's Hospital, Houston, TX. Electronic address:

Purpose: The purpose of this study was to determine the accuracy of fetal echocardiogram (ECHO) for detecting cardiac structural anomalies that may impact Extracorporeal Membrane Oxygenation (ECMO) candidacy in infants with Congenital Diaphragmatic Hernia (CDH).

Methods: A retrospective review was performed on fetuses with CDH (January 2007-June 2017). Inclusion criteria were inborn and at least one prenatal and postnatal ECHO. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.022DOI Listing
February 2019
5 Reads

Fetal Intra-pericardial Morgagni Hernia with effusion affecting one member of a twin gestation.

Echocardiography 2019 Apr 1. Epub 2019 Apr 1.

Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Congenital diaphragmatic hernia (CDH) is a rare type of developmental defect of the diaphragm, occurring in 1 per 2000 pregnancies. Morgagni hernia, in particular, which results from an anterior defect of the diaphragm, is the least common type of CDH (5%). Herniation of the liver into the pericardial space, presenting as a thoracic mass with pericardial effusion, is an extremely rare form of Morgagni hernia. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/echo.14329
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http://dx.doi.org/10.1111/echo.14329DOI Listing
April 2019
3 Reads

Mitral Valve Replacement in Infants using a 15-mm Mechanical Valve.

Ann Thorac Surg 2019 Mar 27. Epub 2019 Mar 27.

Division of Cardiovascular-Thoracic Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL.

Background: The 15-mm mechanical valve was approved by the FDA in March 2018. We review our experience for infants with this valve in the mitral position, focusing on outcomes and timing to repeat mitral valve replacement (MVR).

Methods: Between 2006-2017, 7 patients underwent 8 MVRs (1 repeat) with a 15-mm mechanical valve. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.02.061DOI Listing
March 2019
1 Read

Group B streptococcal sepsis and congenital diaphragmatic hernia: do not overlook normal initial imaging studies!

Arch Dis Child Fetal Neonatal Ed 2019 Mar 29. Epub 2019 Mar 29.

Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/archdischild-2018-316667DOI Listing
March 2019
1 Read

Prediction of Mortality in Newborn Infants With Severe Congenital Diaphragmatic Hernia Using the Chest Radiographic Thoracic Area.

Pediatr Crit Care Med 2019 Mar 28. Epub 2019 Mar 28.

Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

Objectives: To evaluate whether the preoperative chest radiographic thoracic area in newborn infants with congenital diaphragmatic hernia was related to the length of mechanical ventilation and the total length of stay and whether chest radiographic thoracic area predicted survival to discharge from neonatal care.

Design: Retrospective observational cohort study.

Setting: Tertiary neonatal unit at King's College Hospital National Health Service Foundation Trust, London, United Kingdom. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001912DOI Listing
March 2019
1 Read
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Early CDH repair on ECMO: Improved survival but no decrease in ECMO duration (A CDH Study Group Investigation).

J Pediatr Surg 2019 Feb 27. Epub 2019 Feb 27.

Akron Children's Hospital, Department of Surgery, Akron, OH. Electronic address:

Purpose: "Early on-ECMO" repair of CDH entails repair within 48-72 h of cannulation in an effort to optimize pulmonary physiology, shorten ECMO duration, and, ultimately, improve survival. This study evaluated the effect of early on-ECMO repair as compared to leaving patients unrepaired during ECMO.

Methods: The CDH Study Group database was queried for CDH patients requiring ECMO who either underwent repair within the first 72 h after cannulation or remained unrepaired on ECMO. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.063DOI Listing
February 2019
2 Reads

Potential survival benefit with repair of congenital diaphragmatic hernia (CDH) after extracorporeal membrane oxygenation (ECMO) in select patients: Study by ELSO CDH Interest Group.

J Pediatr Surg 2019 Mar 1. Epub 2019 Mar 1.

University of California Irvine Medical Center, Department of Surgery, Orange, CA; Children's Hospital of Orange County, Division of Pediatric Surgery, Orange, CA. Electronic address:

Purpose: Studying the timing of repair in CDH is prone to confounding factors, including variability in disease severity and management. We hypothesized that delaying repair until post-ECMO would confer a survival benefit.

Methods: Neonates who underwent CDH repair were identified within the ELSO Registry. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.02.052DOI Listing
March 2019
1 Read

Sildenafil for Antenatal Treatment of Congenital Diaphragmatic Hernia: from Bench to Bedside.

Curr Pharm Des 2019 Mar 20. Epub 2019 Mar 20.

Cluster Woman and Child, Department of Development and Regeneration, Biomedical Sciences, KU Leuven, Leuven. Belgium.

Background: Persistent pulmonary hypertension (PPH) is one of the main causes of mortality and morbidity in infants affected by congenital diaphragmatic hernia (CDH). Since the structural changes that lead to PPH take place already in utero, a treatment starting in the prenatal phase may prevent the occurrence of this complication.

Objective: To summarize the development process of antenatal sildenafil for CDH. Read More

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http://dx.doi.org/10.2174/1381612825666190320151856DOI Listing
March 2019
3 Reads

Clinical Diagnosis of Classical Cornelia de Lange Syndrome Made From Postmortem Examination of Second Trimester Fetus With Novel NIPBL Pathogenic Variant.

Pediatr Dev Pathol 2019 Mar 19:1093526619834429. Epub 2019 Mar 19.

1 Department of Clinical Genetics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Classical Cornelia de Lange syndrome (CdLS) is a rare genetic disorder which is associated with distinctive facial features, growth retardation, significant intellectual disability and global developmental delay, hirsutism, and upper-limb reduction defects. Classical CdLS is associated with pathogenic variants in NIPBL. We present a clinical diagnosis of classical CdLS made in a second trimester male fetus with advanced maceration who had undergone intrauterine death at 15 + 6 weeks gestation. Read More

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http://dx.doi.org/10.1177/1093526619834429DOI Listing
March 2019
2 Reads

An injectable, degradable hydrogel plug for tracheal occlusion in congenital diaphragmatic hernia (CDH).

Mater Sci Eng C Mater Biol Appl 2019 Jun 14;99:430-439. Epub 2019 Jan 14.

Department of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Italy; INSTM - National Interuniversity Consortium of Materials Science and Technology, Firenze, Italy. Electronic address:

Congenital Diaphragmatic Hernia (CDH) is a birth defect characterized by failed closure of diaphragm, herniation of viscera in the thoracic cavity and impaired lung development. In most severe cases, fetoscopic endoluminal tracheal occlusion (FETO) is performed through a catheter-mounted balloon to contain pulmonary hypoplasia. To support the success rate of FETO and overcome some of the associated drawbacks, this work aimed at finding an injectable, degradable substitute for the balloon not requiring prenatal removal. Read More

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http://dx.doi.org/10.1016/j.msec.2019.01.047DOI Listing
June 2019
5 Reads

Characterization of Esophageal Motility in Infants with Congenital Diaphragmatic Hernia using High Resolution Manometry.

J Pediatr Gastroenterol Nutr 2019 Mar 5. Epub 2019 Mar 5.

Department of Neurosciences, Experimental Oto-Rhino-Laryngology, Deglutology, KU Leuven, Belgium.

Objectives: To characterize esophageal motility and esophago-gastric junction (EGJ) function in infants who underwent repair of an isolated congenital diaphragmatic hernia (iCDH).

Methods: High Resolution Manometry with impedance was used to investigate esophageal motility and EGJ function after diaphragmatic repair in 12 infants with iCDH (11 left-sided; 9 patch repair). They had esophageal motility studies during neonatal admission (n = 12), at 6 months (n = 10) and at 12 months of life (n = 7). Read More

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http://dx.doi.org/10.1097/MPG.0000000000002325DOI Listing
March 2019
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The Impact of Nutrition in the Congenital Diaphragmatic Hernia Treatment.

Pediatr Int 2019 Mar 19. Epub 2019 Mar 19.

Department of Pediatric Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8677, Japan.

Background: The optimum enteral (EN) and parenteral nutrition (PN) regimes during acute management of congenital diaphragmatic hernia (CDH) remain unclear. We aimed to examine the effects of EN and PN on weight gain in CDH patients.

Methods: Multicenter retrospective cohort study including neonates with CDH (born 2006-2010; n = 105) who survived to discharge was conducted. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ped.13837
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http://dx.doi.org/10.1111/ped.13837DOI Listing
March 2019
9 Reads

Repair of a giant diaphragmatic hernia using the dual approach.

J Surg Case Rep 2019 Mar 12;2019(3):rjz064. Epub 2019 Mar 12.

Kuwait University, Faculty of Medicine, Kuwait City, Kuwait.

Bochdalek hernias are diaphragmatic defects seen in pediatrics. About 5-25% of the cases are diagnosed in adulthood, and present with symptoms of chest and abdominal problems. This is a case of an 18-year-old male who presented to the emergency department with epigastric pain, vomiting and dyspnea. Read More

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http://dx.doi.org/10.1093/jscr/rjz064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413371PMC
March 2019
1 Read

Microphthalmia Syndrome 9: Case Report of a Newborn Baby with Pulmonary Hypoplasia, Diaphragmatic Eventration, Microphthalmia, Cardiac Defect and Severe Primary Pulmonary Hypertension.

Am J Case Rep 2019 Mar 18;20:354-360. Epub 2019 Mar 18.

Neonatal Intensive Care Unit, King Fahad Medical City, Children Specialized Hospital, Riyadh, Saudi Arabia.

BACKGROUND The pulmonary hypoplasia/agenesis, diaphragmatic hernia/eventration, anophthalmia/microphthalmia, and cardiac defect (PDAC) syndrome is a rare medical condition presumably of autosomal recessive way of inheritance with only a few reported cases. Recessive mutations in the STRA6 and both recessive and dominant mutations in RARB gene have been identified as the cause of anophthalmia/microphthalmia and other abnormalities included in the PDAC spectrum. However, those mutations have not been found in all PDAC syndrome cases reviewed from the literature. Read More

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http://dx.doi.org/10.12659/AJCR.912873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434610PMC
March 2019
1 Read

Long-term medical and psychosocial outcomes in congenital diaphragmatic hernia survivors.

Arch Dis Child 2019 Mar 15. Epub 2019 Mar 15.

Division of Obstetrics and Gynaecology, University of Western Australia Faculty of Health and Medical Sciences, Perth, Western Australia, Australia.

Objective: Survival rates for congenital diaphragmatic hernia (CDH) are increasing. The long-term outcomes of CDH survivors were compared with a healthy control group to assess the morbidity for guidance of antenatal counselling and long-term follow-up programmes.

Participants And Design: Participants born with CDH in Western Australia 1993-2008 were eligible with matched controls from the general population. Read More

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http://dx.doi.org/10.1136/archdischild-2018-316091DOI Listing
March 2019
2 Reads

A new gentle reduction technique for patients with congenital diaphragmatic hernia-A case report.

Int J Surg Case Rep 2019 Mar 6;57:5-8. Epub 2019 Mar 6.

Department of Pediatric Surgery, University Medicine Mainz, Germany.

Reducing the herniated viscera such as the spleen, the liver, and the bowel in thoracoscopic repair of congenital diaphragmatic hernia can be challenging. The small instruments involved can easily create damage, particularly to the friable capsule of the solid organs involved. We herein demonstrate a new gentle method of reducing the diaphragmatic hernia using sequential twisting of the sac. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417398PMC

Bochdalek hernias in children with late presentation.

Turk Pediatri Ars 2018 Dec 1;53(4):245-249. Epub 2018 Dec 1.

Department of Pediatric Surgery, Fırat University School of Medicine, Elazığ, Turkey.

Aim: Bochdalek hernias, which brought after the neonatal period, are also late-defined cases. In this study, we aimed to present the clinical characteristics of patients with late-presentation Bochdalek hernias who underwent surgery in a reference hospital and our experience regarding their diagnosis.

Material And Methods: Patients with late-presentation Bochdalek hernia who underwent surgery in our clinic between 2001 and 2016 were analyzed retrospectively in terms of the causes of the delay in diagnosis, symptoms, and radiologic and surgical results. Read More

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http://dx.doi.org/10.5152/TurkPediatriArs.2018.0039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408192PMC
December 2018
1 Read

Lung growth index and lung growth ratio - new ultrasound parameters for predicting neonatal survival in fetuses with isolated left sided congenital diaphragmatic hernia?

J Matern Fetal Neonatal Med 2019 Mar 25:1-4. Epub 2019 Mar 25.

a 1st Department of Obstetrics and Gynecology , Medical University of Warsaw , Warsaw , Poland.

Objective: To evaluate the accuracy of several ultrasound parameters used to predict neonatal survival in fetuses with isolated left-sided severe congenital diaphragmatic hernia. This study is to compare different measurement methods. Also, two new ultrasound parameters have been described: the lung growth ratio (LGR) and the lung growth index (LGI). Read More

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http://dx.doi.org/10.1080/14767058.2019.1594193DOI Listing
March 2019
2 Reads

Heterogeneous Pulmonary Response After Tracheal Occlusion: Clues to Fetal Lung Growth.

J Surg Res 2019 Mar 8;239:242-252. Epub 2019 Mar 8.

Division of Pediatric Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora, Colorado. Electronic address:

Background: Understanding inconsistent clinical outcomes in infants with severe congenital diaphragmatic hernia (CDH) after tracheal occlusion (TO) is a crucial step for advancing neonatal care. The objective of this study is to explore the heterogeneous airspace morphometry and the metabolic landscape changes in fetal lungs after TO.

Methods: Fetal lungs on days 1 and 4 after TO were examined using mass spectrometry-based metabolomics, fluorescence lifetime imaging microscopy (FLIM), the number of airspaces, and tissue-to-airspace ratio (TAR). Read More

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http://dx.doi.org/10.1016/j.jss.2019.02.015DOI Listing
March 2019
3 Reads

Rare right congenital diaphragmatic hernia with ileum and colon herniated into thoracic cavity in an 18-year-old adult.

Chin Med J (Engl) 2019 03;132(6):731-732

Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, China.

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http://dx.doi.org/10.1097/CM9.0000000000000135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416098PMC
March 2019
2 Reads

Allogenic tissue-specific decellularized scaffolds promote long-term muscle innervation and functional recovery in a surgical diaphragmatic hernia model.

Acta Biomater 2019 Apr 6;89:115-125. Epub 2019 Mar 6.

Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Corso Stati Uniti 4, 35129 Padova, Italy; Department of Biomedical Sciences, University of Padova, Via Bassi 58/B, 35121 Padova, Italy. Electronic address:

Congenital diaphragmatic hernia (CDH) is a neonatal defect in which the diaphragm muscle does not develop properly, thereby raising abdominal organs into the thoracic cavity and impeding lung development and function. Large diaphragmatic defects require correction with prosthetic patches to close the malformation. This treatment leads to a consequent generation of unwelcomed mechanical stress in the repaired diaphragm and hernia recurrences, thereby resulting in high morbidity and significant mortality rates. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.007DOI Listing
April 2019
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Robotic-Assisted Thoracoscopic Repair of Right-Sided Bochdalek Hernia in Adults: A Two-Case Series.

Innovations (Phila) 2019 Feb 11;14(1):69-74. Epub 2019 Feb 11.

1 Department of Cardiovascular Sciences, East Carolina University Brody School of Medicine, Greenville, NC, USA.

Bochdalek hernia is a congenital diaphragmatic hernia that presents rarely in adulthood. Because of the paucity of cases, no standard repair technique has been identified. Here we present two cases of robotic, thoracoscopic repair of this rare hernia defect. Read More

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http://dx.doi.org/10.1177/1556984518823642DOI Listing
February 2019
1 Read

Correction: MIF inhibition enhances pulmonary angiogenesis and lung development in congenital diaphragmatic hernia.

Pediatr Res 2019 Apr;85(5):735

Division of Neonatal-Perinatal Medicine, Cohen Children's Medical Center, and Lilling Family Neonatal Research Laboratory, Feinstein Institute for Medical Research, Manhasset, NY, USA.

In the original version of this article, the name of the author "Kamesh Ayasolla" was incorrectly given as "Kamesh Ayyasola". This has now been corrected to "Kamesh Ayasolla" in both the PDF and HTML versions of the article. Read More

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http://dx.doi.org/10.1038/s41390-019-0362-3DOI Listing
April 2019
1 Read

Expression of soluble receptor for advanced glycation end products (sRAGE) is associated with disease severity in congenital diaphragmatic hernia.

Am J Physiol Lung Cell Mol Physiol 2019 Mar 6. Epub 2019 Mar 6.

Institute for Clinical Chemistry and Clinical Pharmacology, University of Bonn.

Pulmonary hypertension (PH) and lung hypoplasia are major contributors to morbidity and mortality in newborns with congenital diaphragmatic hernia (CDH). The soluble receptor for advanced glycation end products (sRAGE) is a marker of endothelial function and might be associated with disease severity in CDH newborns. In a cohort of 30 CDH newborns and 20 healthy control newborns, sRAGE concentration was measured at birth, at 6 hours, 12 hours, 24 hours, 48 hours, and 7-10 days. Read More

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http://dx.doi.org/10.1152/ajplung.00359.2018DOI Listing
March 2019
1 Read

Left ventricular cardiac output is a reliable predictor of extracorporeal life support in neonates with congenital diaphragmatic hernia.

J Perinatol 2019 Mar 5. Epub 2019 Mar 5.

CHOC Children's Hospital, Division of Neonatology, Orange, CA, USA.

Objective: Congenital diaphragmatic hernia (CDH) is a treatable condition but despite optimal management, some patients require extracorporeal life support (ECLS). This study evaluates the association of left ventricular (LV) cardiac output and the need for ECLS.

Study Design: Single center, retrospective chart review from 1/1/2012 through 7/1/2018. Read More

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http://dx.doi.org/10.1038/s41372-019-0348-3DOI Listing
March 2019
2 Reads

Rescue high frequency ventilation for congenital diaphragmatic hernia.

J Neonatal Perinatal Med 2019 Feb 23. Epub 2019 Feb 23.

Department of Pediatrics and Communicable Diseases, Division of Neonatal-Perinatal Medicine, Ann Arbor, Michigan, USA.

Introduction: High frequency jet (HFJV) and oscillatory (HFOV) ventilation were used to rescue newborns with congenital diaphragmatic hernia (CDH), who failed conventional mechanical ventilation (CV). Changes in ventilator settings and pulmonary gas exchange were evaluated following transition to high frequency ventilation (HFV).

Methods: Records of patients with CDH rescued with HFV prior to surgical intervention between 2006 and 2015 were reviewed. Read More

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http://dx.doi.org/10.3233/NPM-1813DOI Listing
February 2019
1 Read

Congenital heart disease associated with congenital diaphragmatic hernia: A systematic review on incidence, prenatal diagnosis, management, and outcome.

J Pediatr Surg 2019 Jan 31. Epub 2019 Jan 31.

Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, Canada; Department of Surgery, University of Toronto, Toronto, Canada. Electronic address:

Purpose: The purpose of this study was to evaluate the impact of congenital heart disease (CHD) on infants with congenital diaphragmatic hernia (CDH).

Methods: Using a defined search strategy (PubMed, Cochrane, Embase, Web of Science MeSH headings), we searched studies reporting the incidence, management, and outcome of CDH infants born with associated CHD.

Results: Of 6410 abstracts, 117 met criteria. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.018DOI Listing
January 2019
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The presence of a hernia sac in isolated congenital diaphragmatic hernia is associated with less disease severity: A retrospective cohort study.

J Pediatr Surg 2019 Jan 31. Epub 2019 Jan 31.

Department of Surgery, Division of Pediatric Surgery, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Pediatrics, and Child Health, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

Introduction: We aimed to determine if the presence of a hernia sac in neonates with isolated congenital diaphragmatic hernia (CDH) was associated with better clinical outcomes.

Methods: We performed a retrospective cohort study of infants with isolated CDH from 1991 to 2015. Primary outcome measures were oxygen-dependence and mortality at 28 days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223468193005
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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.016DOI Listing
January 2019
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Transport on extracorporeal membrane oxygenation for congenital diaphragmatic hernia: A unique center experience.

J Pediatr Surg 2019 Feb 8. Epub 2019 Feb 8.

ECMO Center Karolinska, Department of Pediatric Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Background: Support on Extracorporeal oxygenation membrane (ECMO) represents the last therapeutic option in the management of respiratory failure and pulmonary hypertension refractory to treatment in patients with congenital diaphragmatic hernia (CDH).

Aim: The objective of this work was to present our experience of all the cases of CDH that we have transported on ECMO.

Material And Methods: Medical records of patients, national and international, with CDH transported by our service on ECMO from 1997 to 2018 were reviewed. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.11.022DOI Listing
February 2019
2 Reads

Preoperative cardiopulmonary evaluation in specific neonatal surgery.

Semin Pediatr Surg 2019 Feb 18;28(1):3-10. Epub 2019 Jan 18.

Division of Pediatric General and Thoracic Surgery, The Montreal Children's Hospital, 1001 Decarie Blvd, Room B04.2318, Montreal, QC, Canada. Electronic address:

Preoperative assessment of surgical neonates often relates to issues of prematurity, low birth weight, or associated malformations. This review explores the preoperative cardiopulmonary evaluation in specific newborn surgical populations, the role of echocardiography in congenital diaphragmatic hernia perioperative management, the impact of bronchopulmonary dysplasia in the ex-preterm surgical neonate and a brief discussion on the risk of general anesthesia and specific anesthetic considerations for any surgical neonate. Newborns with congenital anomalies requiring early general surgical intervention should have an assessment for congenital heart disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10558586193000
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http://dx.doi.org/10.1053/j.sempedsurg.2019.01.002DOI Listing
February 2019
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Congenital diaphragmatic hernia diagnosed in adulthood during laparoscopy.

Can J Anaesth 2019 Feb 26. Epub 2019 Feb 26.

Department of Transplantation Surgery, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

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http://dx.doi.org/10.1007/s12630-019-01335-6DOI Listing
February 2019

Strangulated Congenital Diaphragmatic Hernia of Bochdalek Diagnosed in Late Pregnancy: A Case Report and Review of the Literature.

J Obstet Gynaecol Can 2019 Feb 22. Epub 2019 Feb 22.

Department of Surgery, Centre Hospitalier Universitaire de Québec, Québec, QC. Electronic address:

Background: Congenital diaphragmatic hernia is an unusual condition in the adult population because it is mostly a neonatal diagnosis. This entity may be triggered by pregnancy and threaten the life of the mother and her fetus.

Case: This report presents the case of a maternal diaphragmatic hernia diagnosed at 35 weeks of pregnancy with epigastric pain, nausea, and vomiting. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.12.024DOI Listing
February 2019
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Cystic and pseudocystic pulmonary malformations in children: Clinico-pathological correlation.

Ann Diagn Pathol 2019 Feb 16;39:78-85. Epub 2019 Feb 16.

Unidad de Investigación Médica en Enfermedades Respiratorias, Unidad Médica de Alta Especialidad, Hospital de Pediatría Silvestre Frenk Freund, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, Mexico.

Pulmonary malformations are rare disorders, with cystic and pseudocystic pulmonary malformations (CPPM) the most frequent, and constitute the first cause of lobectomy in children <1 year of age. Morphological overlap of congenital cystic pulmonary lesions might correspond to a spectrum of lesions in which bronchial atresia is a common etiopathogenetic mechanism. We aimed to report the frequency of CPPM resected in a tertiary-level hospital and to evaluate the degree of agreement between presurgical and anatomopathological diagnoses. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.005DOI Listing
February 2019
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Approach to a large rare diaphragmatic hernia in a patient undergoing cardiac surgery.

J Surg Case Rep 2019 Feb 12;2019(2):rjz038. Epub 2019 Feb 12.

Department of Cardiothoracic Surgery, Monash Medical Centre, Melbourne, Australia.

Hernia of Morgagni is an unusual congenital defect of the sternal portion of the diaphragm. Its concurrence with cardiac surgical pathology is rarely described in the literature. Notwithstanding, huge hernia of Morgagni have been noted to cause serious peri-operative impediment and complications. Read More

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http://dx.doi.org/10.1093/jscr/rjz038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371852PMC
February 2019

The effects of tracheal occlusion on Wnt signaling in a rabbit model of congenital diaphragmatic hernia.

J Pediatr Surg 2019 Jan 31. Epub 2019 Jan 31.

Division of Paediatric General Surgery, Children's Hospital London Health Science Centre, Schulich School of Medicine, Western University, London, ON, Canada. Electronic address:

Purpose: Tracheal occlusion (TO) reverses pulmonary hypoplasia (PH) in congenital diaphragmatic hernia (CDH), but its mechanism of action remains poorly understood. Wnt signaling plays a critical role in lung development, but few studies exist. The purpose of our study was to a) confirm that our CDH rabbit model produced PH which was reversed by TO and b) determine the effects of CDH +/- TO on Wnt signaling. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.024DOI Listing
January 2019
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Risk-stratification enables accurate single-center outcomes assessment in congenital diaphragmatic hernia (CDH).

J Pediatr Surg 2019 Jan 31. Epub 2019 Jan 31.

Division of Pediatric Surgery, Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, TN, USA.

Background: Management of CDH is highly variable from center to center, as are patient outcomes. The purpose of this study was to examine risk-stratified survival and extracorporeal membrane oxygenation (ECMO) rates at a single center, and to determine whether adverse outcomes are related to patient characteristics or management.

Methods: A retrospective single-center review of CDH patients was performed, and outcomes compared to those reported by the CDH Study Group (CDHSG) registry. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.020DOI Listing
January 2019
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Diaphragmatic hernia with isolated shoulder pain evoked by surfeit.

Ann Transl Med 2019 Jan;7(1):11

Department of thoracic and cardiovascular Surgery, College of medicine, Chungbuk National University, Cheongju, Republic of Korea.

Bochdalek hernia in adult is extremely rare, so symptoms or indications of surgery are not reported enough. Here we report a case of small-sized Bochdalek hernia with isolated shoulder pain that resolved after surgical reduction of hernia. A 25-year-old man with diaphragmatic mass was referred to out-patient clinic. Read More

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http://dx.doi.org/10.21037/atm.2018.11.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351367PMC
January 2019

Prenatal prediction of survival in congenital diaphragmatic hernia: An audit of postnatal outcomes.

J Pediatr Surg 2019 Jan 31. Epub 2019 Jan 31.

Division of Pediatric General and Thoracic Surgery, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada. Electronic address:

Purpose: Effective antenatal counseling in congenital diaphragmatic hernia (CDH) relies on proper measurement of prognostic indices. This quality initiative audited the accuracy of prenatal imaging with postnatal outcomes at two tertiary pediatric referral centers.

Methods: Prenatal lung-head ratio (LHR) and total fetal lung volume (TFLV) for CDH patients treated between 2006 and 2017 were retrieved. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223468193005
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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.021DOI Listing
January 2019
3 Reads