6,691 results match your criteria Diaphragmatic Hernias Congenital


Requirement and Duration of Tube Feed Supplementation among Congenital Diaphragmatic Hernia Patients.

J Pediatr Surg 2019 Jan 31. Epub 2019 Jan 31.

Division of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, ON, Canada; Department of Surgery, University of Toronto, Toronto, ON, Canada. Electronic address:

Purpose: Oral feeds pose a challenge for congenital diaphragmatic hernia (CDH) infants. Tube feed (TF) supplementation may be required to support the achievement of normal growth. The aim of this study was to determine the duration and factors associated with TF use in CDH infants at our institution. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.017DOI Listing
January 2019
1 Read

Prenatal diagnosis and management of congenital diaphragmatic hernia.

Best Pract Res Clin Obstet Gynaecol 2019 Jan 5. Epub 2019 Jan 5.

Academic Department of Development and Regeneration, Cluster Woman and Child, Biomedical Sciences, KU Leuven, Belgium; Clinical Department of Obstetrics & Gynaecology, KU Leuven, Leuven, Belgium; Institute for Women's Health, University College London, London, UK; European Reference Network on Rare and Inherited Congenital Anomalies "ERNICA". Electronic address:

Congenital diaphragmatic hernia is characterized by failed closure of the diaphragm, thereby allowing abdominal viscera to herniate into the thoracic cavity and subsequently interfering with normal lung development. At birth, pulmonary hypoplasia leads to respiratory insufficiency and persistent pulmonary hypertension (PHT), that is lethal in up to 32% of patients. In isolated cases, the outcome may be predicted prenatally by medical imaging and advanced genetic testing. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2018.12.010DOI Listing
January 2019
1 Read

Comparison of early postnatal prediction models for survival in congenital diaphragmatic hernia.

J Perinatol 2019 Feb 15. Epub 2019 Feb 15.

Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA.

Objective: To compare the PF-PCO equation-partial pressure of arterial oxygen (PaO)/fraction of inspired oxygen (FiO) minus partial pressure of carbon dioxide (PCO)-to three other tools for postnatal prediction of survival in infants with congenital diaphragmatic hernia (CDH).

Study Design: A retrospective analysis of 203 infants with CDH from 1 January 2003 to 30 June 2018. Area under the curve (AUC) analysis was performed for survival and secondary outcomes of survival without extracorporeal membrane oxygenation support (ECMO) and death despite ECMO. Read More

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http://www.nature.com/articles/s41372-019-0335-8
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http://dx.doi.org/10.1038/s41372-019-0335-8DOI Listing
February 2019
1 Read

Evaluation and Monitoring of Pulmonary Hypertension in Neonates With Congenital Diaphragmatic Hernia.

Curr Treat Options Cardiovasc Med 2019 Feb 15;21(2):11. Epub 2019 Feb 15.

Department of Pediatrics, University of Minnesota, 2450 Riverside Ave, East Building, 5th Floor, Minneapolis, MN, 55454, USA.

Purpose Of Review: This review aims to describe the assessment of pulmonary hypertension and ventricular function in neonates with congenital diaphragmatic hernia and the long-term follow-up of their pulmonary vascular disease.

Recent Findings: In 2015, the pediatric pulmonary hypertension guidelines from the American Heart Association and American Thoracic Society suggested class I level of evidence B guidelines for routine evaluation of patients with congenital diaphragmatic hernia, including longitudinal care in an interdisciplinary pulmonary hypertension program and following the recommendations offered for all children with pulmonary hypertension. Congenital diaphragmatic hernia causes compression of the lungs during critical stages of fetal development and results in lung hypoplasia. Read More

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http://dx.doi.org/10.1007/s11936-019-0711-xDOI Listing
February 2019

The Pediatric Surgical Team: a Model for Increased Surgeon Index Case Exposure.

J Pediatr Surg 2019 Jan 21. Epub 2019 Jan 21.

Kapi'olani Medical Center for Children, 1319 Punahou St., Honolulu, HI, USA 96826.

Background/purpose: High surgical volume for both surgeons and hospital systems has been linked to improved outcomes for many surgical problems, yet case volumes per pediatric surgeon are diminishing nationally in complex pediatric surgery. We therefore sought to review our experience in a geographically isolated setting where a surgical team approach has been used to improve per-surgeon exposure to index pediatric surgical cases.

Methods: As a surgical group, we incorporated a surgical team approach to complex pediatric surgical cases in 2010. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.12.018DOI Listing
January 2019

MIF inhibition enhances pulmonary angiogenesis and lung development in congenital diaphragmatic hernia.

Pediatr Res 2019 Feb 13. Epub 2019 Feb 13.

Division of Neonatal-Perinatal Medicine, Cohen Children's Medical Center, and Lilling Family Neonatal Research Laboratory, Feinstein Institute for Medical Research, Manhasset, NY, USA.

Background: Congenital diaphragmatic hernia (CDH) is a complex birth anomaly with significant mortality and morbidity. Lung hypoplasia and persistent pulmonary hypertension (PPHN) limit survival in CDH. Macrophage migration inhibitory factor (MIF), a key regulator of innate immunity, is involved in hypoxia-induced vascular remodeling and PPHN. Read More

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http://www.nature.com/articles/s41390-019-0335-6
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http://dx.doi.org/10.1038/s41390-019-0335-6DOI Listing
February 2019
4 Reads

Congenital diaphragmatic hernia and exercise capacity, a longitudinal evaluation.

Pediatr Pulmonol 2019 Feb 11. Epub 2019 Feb 11.

Department of Pediatric Surgery and Intensive Care, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.

Objective: Children with congenital diaphragmatic hernia (CDH) suffer from long-term pulmonary morbidity. Longitudinal data of exercise capacity in these children are lacking. We hypothesized that exercise capacity would be impaired in children with CDH and deteriorates over time. Read More

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http://dx.doi.org/10.1002/ppul.24264DOI Listing
February 2019
1 Read

Diagnostic challenges in late-presenting congenital diaphragmatic hernia: a 16-year experience from tertiary care centre in North India.

Trop Doct 2019 Feb 10:49475519827109. Epub 2019 Feb 10.

3 Professor, Department of Paediatrics, PGIMS, Rohtak, Haryana, India.

With increasing use of ultrasound screening, the prenatal diagnosis of congenital diaphragmatic hernia (CDH) in better resourced areas has become the norm. However, early diagnosis is still not universal in resource-poor settings and late presentations of CDH continue. We retrospectively analysed the medical records of children operated for late-presenting CDH from 2001 to 2016 at our tertiary care centre in North India. Read More

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http://dx.doi.org/10.1177/0049475519827109DOI Listing
February 2019
1 Read

Neonatal cardiopulmonary transition in an ovine model of congenital diaphragmatic hernia.

Arch Dis Child Fetal Neonatal Ed 2019 Feb 6. Epub 2019 Feb 6.

The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia.

Objective: Infants with a congenital diaphragmatic hernia (CDH) are at high risk of developing pulmonary hypertension after birth, but little is known of their physiological transition at birth. We aimed to characterise the changes in cardiopulmonary physiology during the neonatal transition in an ovine model of CDH.

Methods: A diaphragmatic hernia (DH) was surgically created at 80 days of gestational age (dGA) in 10 fetuses, whereas controls underwent sham surgery (n=6). Read More

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http://dx.doi.org/10.1136/archdischild-2018-316045DOI Listing
February 2019
2 Reads

Effects of tracheal occlusion on the neonatal cardiopulmonary transition in an ovine model of diaphragmatic hernia.

Arch Dis Child Fetal Neonatal Ed 2019 Feb 6. Epub 2019 Feb 6.

The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia.

Objective: Fetoscopic endoluminal tracheal occlusion (FETO) aims to reverse pulmonary hypoplasia associated with congenital diaphragmatic hernia (CDH) and mitigate the associated respiratory insufficiency and pulmonary hypertension after birth. We aimed to determine whether FETO improves the cardiopulmonary transition at birth in an ovine model of CDH.

Methods: In 12 ovine fetuses with surgically induced diaphragmatic hernia (DH; 80 dGA), an endotracheal balloon was placed tracheoscopically at ≈110 dGA and removed at ≈131 dGA (DH+FETO), while 10 were left untreated (DH). Read More

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http://fn.bmj.com/lookup/doi/10.1136/archdischild-2018-31604
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http://dx.doi.org/10.1136/archdischild-2018-316047DOI Listing
February 2019
2 Reads

The Impact of Pediatric Surgical Specialty Meetings: A 5-year Analysis of Presented Abstracts.

J Surg Res 2019 Feb 2;238:16-22. Epub 2019 Feb 2.

Yale School of Medicine, Department of Surgery, Section of Pediatric Surgery, New Haven, Connecticut. Electronic address:

Background: Abstracts presented at the American Academy of Pediatrics Section on Surgery (AAP) and American Pediatric Surgical Association (APSA) meetings can be taken as a reasonable representation of academic activity in pediatric surgery. We sought to assess ongoing trends in pediatric surgical research by analyzing the scientific content of each association's yearly meeting.

Methods: Abstracts presented at AAP and APSA between 2009 and 2013 were identified from the final printed programs (n = 910). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804183082
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http://dx.doi.org/10.1016/j.jss.2018.11.034DOI Listing
February 2019
4 Reads

Is Milrinone Effective for Infants with Mild-to-Moderate Congenital Diaphragmatic Hernia?

Am J Perinatol 2019 Feb 1. Epub 2019 Feb 1.

Division of Neonatology, Primary Children's Hospital, Salt Lake City, Utah.

Background:  Pulmonary hypertension with left ventricular dysfunction commonly occurs in congenital diaphragmatic hernia (CDH). Milrinone, a phosphodiesterase-III inhibitor with lusitropic and vasodilator effects, is used in up to 30% of CDH infants across the United States. No randomized trials have tested the efficacy or safety of milrinone in CDH neonates. Read More

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http://dx.doi.org/10.1055/s-0039-1678558DOI Listing
February 2019
2 Reads

Laparoscopic repair of a Morgagni hernia with extra-abdominal transfascial sutures.

BMJ Case Rep 2019 Jan 29;12(1). Epub 2019 Jan 29.

Surgery C, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

Morgagni hernia is a congenital diaphragmatic hernia. It is rare, usually asymptomatic, and most of the times incidentally discovered during adulthood. A 77-year-old female patient was incidentally diagnosed with Morgagni hernia. Read More

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http://dx.doi.org/10.1136/bcr-2018-227600DOI Listing
January 2019
1 Read

Pathophysiological Mechanism of Extravasation via Umbilical Venous Catheters.

Pediatr Dev Pathol 2019 Jan 25:1093526619826714. Epub 2019 Jan 25.

2 Neonatal Unit, Birmingham Women's Hospital, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.

A rare complication of umbilical venous catheter (UVC) insertion is the extravasation of the infusate into the peritoneal cavity. We report 3 cases of abdominal extravasation of parenteral nutrition (PN) fluid via UVCs. Two of these cases presented as "acute abdomen" which were assumed to be necrotizing enterocolitis clinically; however, during postmortem, PN ascites and liver necrosis were found. Read More

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http://dx.doi.org/10.1177/1093526619826714DOI Listing
January 2019
2 Reads

Liver heterotopia associated with congenital diaphragmatic hernia: Two case reports and a review of the literature.

Medicine (Baltimore) 2019 Jan;98(4):e14211

Division of Pediatric Surgery, Department of Surgery, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Rationale: Liver heterotopia associated with congenital diaphragmatic hernia (CDH) is a rare condition; to the best of our knowledge, only 17 cases have been reported to date. The histogenesis and clinicopathological features are largely unknown. We herein report 2 cases of liver heterotopia associated with CDH along with 17 cases described in the literature to shed light on their clinicopathological characteristics. Read More

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http://dx.doi.org/10.1097/MD.0000000000014211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358339PMC
January 2019
2 Reads

Congenital diaphragmatic hernia: the good, the bad, and the tough.

Pediatr Surg Int 2019 Mar 24;35(3):303-313. Epub 2019 Jan 24.

Division of Pediatric General and Thoracic Surgery, The Center for Fetal Cellular and Molecular Therapy, Cincinnati Fetal Center, 3333 Burnet Avenue, MLC 11025, Cincinnati, OH, 45229-3039, USA.

Objectives: We aim to determine factors that are associated with better outcomes of CDH patients.

Methods: A retrospective review was performed on all CDH patients admitted to our institution between 2003 and 2016. This study was performed at a single institution which has a fetal care center. Read More

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http://dx.doi.org/10.1007/s00383-019-04442-zDOI Listing

Prognostic value of the oxygenation index to predict survival and timing of surgery in infants with congenital diaphragmatic hernia.

J Pediatr Surg 2018 Dec 27. Epub 2018 Dec 27.

Department of Paediatric Surgery, King's College Hospital, London SE5 9RS. Electronic address:

Aims: To compare the mean oxygenation index on day1 (MOId1) with the best OI on day1 (BOId1) in predicting 30-day mortality in congenital diaphragmatic hernia (CDH). In addition, to determine whether serial OIs in the first 48 h after birth and preoperative OI (PreOp-OI), were associated with optimal timing of surgery, ventilation requirement and hospital stay in infants with CDH.

Methods: The medical records of infants with antenatally diagnosed CDH during 2009-2015 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.11.014DOI Listing
December 2018
1 Read

Lung ultrasound findings in congenital diaphragmatic hernia.

Eur J Pediatr 2019 Jan 21. Epub 2019 Jan 21.

Division of Neonatology, Careggi University Hospital of Florence, Largo Brambilla, 3, 50134, Florence, Italy.

Congenital diaphragmatic hernia (CDH) occurs in approximately 1 in 2500 to 5000 infants. The use of lung ultrasound (LUS) for its diagnosis has been reported in only two case reports. The aim of this study was to report the LUS pattern of CDH in a case series of infants with respiratory distress. Read More

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http://dx.doi.org/10.1007/s00431-019-03321-yDOI Listing
January 2019
2 Reads

Development of the Pediatric Extracorporeal Membrane Oxygenation Prediction Model for Risk-Adjusting Mortality.

Pediatr Crit Care Med 2019 Jan 18. Epub 2019 Jan 18.

Department of Pediatrics, Inova Fairfax Hospital, Fall Church, VA.

Objectives: To develop a prognostic model for predicting mortality at time of extracorporeal membrane oxygenation initiation for children which is important for determining center-specific risk-adjusted outcomes.

Design: Multivariable logistic regression using a large national cohort of pediatric extracorporeal membrane oxygenation patients.

Setting: The ICUs of the eight tertiary care children's hospitals of the Collaborative Pediatric Critical Care Research Network. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001882DOI Listing
January 2019
9 Reads
2.338 Impact Factor

Long tail balloon as a new approach for fetoscopic tracheal occlusion for a treatment of severe congenital diaphragmatic hernia.

J Obstet Gynaecol Res 2019 Jan 17. Epub 2019 Jan 17.

University Clinic of Pediatrics, Martin Luther University Halle-Wittenberg, Halle, Germany.

Severe congenital diaphragmatic hernia (CDH) remains a significant challenge for neonatal specialists. In order to reduce complications during extraction of the surgical balloon after fetoscopic tracheal occlusion (FETO) CDH, we have developed a FETO with a 'long tail balloon' of 2.5 mL volume. Read More

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http://dx.doi.org/10.1111/jog.13895DOI Listing
January 2019
3 Reads

Variable phenotypic expression of Apert syndrome in monozygotic twins.

Clin Case Rep 2019 Jan 11;7(1):54-57. Epub 2018 Nov 11.

Department of Gynecology and Obstetrics CHRU de Nancy Nancy France.

Apert syndrome in monozygotic twins can lead to different phenotypic expression of the disease in the two fetuses. Apert syndrome can be associated with congenital left diaphragmatic hernia and cleft palate. Read More

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http://dx.doi.org/10.1002/ccr3.1915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333066PMC
January 2019
3 Reads

Left sided flank pain due to Bochdalek hernia with intrathoracic kidney.

Scand J Urol 2019 Jan 17:1-2. Epub 2019 Jan 17.

a Department of Urology , Rigshospitalet , Denmark.

A 40 year old woman had undergone surgery as a newborn due to a left sided congenital Bochdalek hernia with the ventricle, spleen, left kidney and adrenal gland located intrathoracically. After three pregnancies, she developed left sided flank pain and dyspnea. A CT scan showed a diaphragmatic hernia with a malrotated intrathoracic placed left kidney with minimal hydronephrosis. Read More

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http://dx.doi.org/10.1080/21681805.2018.1545798DOI Listing
January 2019
2 Reads

Perinatal diagnosis and management of early-onset Marfan syndrome: case report and systematic review.

J Matern Fetal Neonatal Med 2019 Jan 17:1-12. Epub 2019 Jan 17.

a Hospital General Universitario Gregorio Marañón , Madrid , Spain.

Early onset Marfan syndrome is the most severe form of Marfan syndrome diagnosed during perinatal period. Early onset Marfan syndrome is associated with high mortality rates, usually within the first 2 years of life. First, we present a case of prenatally diagnosed early onset Marfan syndrome in a dichorionic diamniotic twin pregnancy, where suspicion was raised at 35 weeks of gestation. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2018.1
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http://dx.doi.org/10.1080/14767058.2018.1552935DOI Listing
January 2019
6 Reads

Postnatal Ultrasound to Determine the Surgical Strategy for Congenital Diaphragmatic Hernia.

J Ultrasound Med 2019 Jan 16. Epub 2019 Jan 16.

Departments of Radiology, Saitama Children's Medical Center, Saitama, Japan.

Objectives: To compare defect sizes in congenital diaphragmatic hernia (CDH) measured by postnatal ultrasound (US) between neonates who underwent thoracoscopic surgery and neonates who underwent open surgery and between neonates who underwent primary repair and those who underwent patch repair; additionally, to compare the accuracy of US diagnosis with that of surgical diagnosis for the location of the diaphragmatic hernia and the hernial contents.

Methods: We included 8 neonates who underwent preoperative US evaluations of CDH. We compared anterior-to-posterior diaphragm defect sizes between thoracoscopic and open surgery approaches and between primary and patch repair by using the Mann-Whitney U test. Read More

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http://dx.doi.org/10.1002/jum.14929DOI Listing
January 2019
3 Reads

Fetal endoscopic tracheal occlusion reduces pulmonary hypertension in severe congenital diaphragmatic hernia.

Ultrasound Obstet Gynecol 2019 Jan 14. Epub 2019 Jan 14.

Texas Children's Fetal Center, Baylor College of Medicine, Houston, TX.

Objective: Fetal endoscopic tracheal occlusion (FETO) is associated with increased perinatal survival and reduced need for Extracorporeal Membrane Oxygenation (ECMO) among fetuses with severe congenital diaphragmatic hernia (CDH). This study evaluates the impact of FETO on the resolution of pulmonary hypertension (PH) in fetuses with isolated CDH.

Methods: All fetuses evaluated for CDH between January 2004 and July 2017 at a single institution were included. Read More

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http://dx.doi.org/10.1002/uog.20216DOI Listing
January 2019
2 Reads

Nuss procedure for patients with pectus excavatum with a history of intrathoracic surgery.

J Plast Reconstr Aesthet Surg 2018 Dec 15. Epub 2018 Dec 15.

Department of Plastic and Reconstructive Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho Showa-ku, Nagoya, Aichi 464-8560, Japan.

Background: The aim of this study was to demonstrate the feasibility and safety of the Nuss procedure for patients with pectus excavatum (PE) with a history of intrathoracic surgery.

Patients: From April 2010 to December 2013, we performed 6 cases of PE repair in patients with a history of intrathoracic surgery. The causes of previous operations were congenital cystic adenomatoid malformation in 4 patients and congenital diaphragmatic hernia in 2. Read More

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http://dx.doi.org/10.1016/j.bjps.2018.12.027DOI Listing
December 2018
2 Reads

Delayed Presentation of Congenital Diaphragmatic Hernia.

Authors:
L K Rajbanshi

Kathmandu Univ Med J (KUMJ) 2018 Apr-Jun;16(62):199-200

Department of Anesthesia, Birat Medical College, Biratnagar, Morang.

Delayed presentation of congenital diphragmatic hernia is a rare condition which can present in later stage of life either with the nonspecific complains or acute complians of shortness of breath. The clinical features and the radiological findings can be confused with pneumothorax leading to inadvertant insertion of chest tube. Immediate and accurate diagnosis of the condition is required for the better outcome. Read More

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January 2019
3 Reads

Intrathoracic renal ectopia with congenital diaphragmatic hernia.

Arch Dis Child Fetal Neonatal Ed 2019 Jan 13. Epub 2019 Jan 13.

Neonatal Intensive Care Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.

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http://fn.bmj.com/lookup/doi/10.1136/archdischild-2018-31619
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http://dx.doi.org/10.1136/archdischild-2018-316195DOI Listing
January 2019
7 Reads

Congenital diaphragmatic hernia sacs: prenatal imaging and associated postnatal outcomes.

Pediatr Radiol 2019 Jan 11. Epub 2019 Jan 11.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: The presence of a hernia sac in congenital diaphragmatic hernia (CDH) has been reported to be associated with higher lung volumes and better postnatal outcomes.

Objective: To compare prenatal imaging (ultrasound and MRI) prognostic measurements and postnatal outcomes of CDH with and without hernia sac.

Materials And Methods: We performed database searches from January 2008 to March 2017 for surgically proven cases of CDH with and without hernia sac. Read More

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http://dx.doi.org/10.1007/s00247-018-04334-9DOI Listing
January 2019
1 Read

Reproducibility of fetal lung-to-head ratio in left diaphragmatic hernia across the North American Fetal Therapy Network (NAFTNet).

Prenat Diagn 2019 Jan 7. Epub 2019 Jan 7.

Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Mayo Clinic College of Medicine, Rochester, MN, USA.

Objective: To determine the antenatal sonographic lung area measurement method in left congenital diaphragmatic hernia (CDH) with the highest interrater agreement among North American Fetal Therapy Network (NAFTNet) centers within and outside the fetoscopic tracheal occlusion (FETO) consortium and in comparison with a European "expert" reviewer (ER).

Methods: Nineteen members from nine FETO consortium centers and 29 reviewers from 17 non-FETO centers reviewed ultrasound clips of the chest from 13 fetuses with isolated left CDH and were asked to select a static plane for lung area measurement using anteroposterior (AP), longest, and trace methods. Interrater agreement in lung area measurements was determined using intraclass correlation coefficient (ICC). Read More

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http://dx.doi.org/10.1002/pd.5413DOI Listing
January 2019
1 Read
2.514 Impact Factor

Outcomes of Congenital Diaphragmatic Hernia in One of the Twins.

Am J Perinatol 2019 Jan 4. Epub 2019 Jan 4.

Department of Pediatric Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective:  Congenital diaphragmatic hernia (CDH) occurred in one of the twins is rarely seen. This study aims to describe the clinical features and outcomes of this special CDH.

Study Design:  The medical records of all CDH neonates treated in our institution between 2010 and 2016 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1055/s-0038-1676830DOI Listing
January 2019
10 Reads

Management of persistent pulmonary hypertension in newborns with ECMO support: a single center's experience.

World J Pediatr 2019 Jan 3. Epub 2019 Jan 3.

Heart Institute, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310000, China.

Background: To summarize the experience of management of persistent pulmonary hypertension of the newborn (PPHN) with extracorporeal membrane oxygenation (ECMO) support.

Methods: We presented three neonates with PPHN supported by ECMO in our center. Medical records and patient management notes were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s12519-018-0215-xDOI Listing
January 2019
2 Reads

Application of a postnatal prediction model of survival in CDH in the era of fetal therapy.

J Matern Fetal Neonatal Med 2019 Jan 4:1-6. Epub 2019 Jan 4.

b Department of Neonatology , University Hospitals Leuven , Leuven , Belgium.

Background: The disease severity in patients with a congenital diaphragmatic hernia (CDH) is highly variable. To compare patient outcomes, set up clinical trials and come to severity-based treatment guidelines, a performant prediction tool early in neonatal life is needed.

Objective: The primary purpose of this study was to validate the CDH study group (SG) prediction model for survival in neonates with CDH, including patients who had fetal therapy. Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2018.1
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http://dx.doi.org/10.1080/14767058.2018.1530755DOI Listing
January 2019
6 Reads

Lung Transplantation for Late-Onset Pulmonary Hypertension in a Patient with Congenital Diaphragmatic Hernia.

European J Pediatr Surg Rep 2018 Jan 26;6(1):e100-e103. Epub 2018 Dec 26.

Department of Neonatal Surgery, Bambino Gesù Children's Hospital, Rome, Italy.

Lung hypoplasia and pulmonary hypertension (PH) in association with congenital diaphragmatic hernia (CDH) may cause fatal respiratory failure. Lung transplantation (Ltx) may represent an option for CDH-related end-stage pulmonary failure. The aim of this study is to report a patient with CDH who underwent Ltx or combined heart-lung transplantation (H-Ltx). Read More

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http://dx.doi.org/10.1055/s-0038-1675377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306278PMC
January 2018
2 Reads

Characterization of a reversible thermally-actuated polymer-valve: A potential dynamic treatment for congenital diaphragmatic hernia.

PLoS One 2018 27;13(12):e0209855. Epub 2018 Dec 27.

Electrical and Electronics Systems Research Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, United States of America.

Background: Congenital diaphragmatic hernia (CDH) is a fetal defect comprising an incomplete diaphragm and the herniation of abdominal organs into the chest cavity that interfere with fetal pulmonary development. Though the most promising treatment for CDH is via interventional fetoscopic tracheal occlusion (TO) surgery in-utero, it has produced mixed results due to the static nature of the inserted occlusion. We hypothesize that a suitable noninvasively-actuatable, cyclic-release tracheal occlusion device can be developed to enable dynamic tracheal occlusion (dTO) implementation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209855PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307748PMC
December 2018
5 Reads

Predictors of Long-Term Pulmonary Morbidity in Children with Congenital Diaphragmatic Hernia.

Eur J Pediatr Surg 2019 Feb 24;29(1):120-124. Epub 2018 Dec 24.

Division of Pediatric General and Thoracic Surgery, Department of Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada.

Purpose:  The aim is to identify prognostic markers of long-term pulmonary morbidity among congenital diaphragmatic hernia (CDH) survivors.

Methods:  A single-institution, retrospective review was performed on all CDH patients from 2000 and 2012 (REB#1000053383). Liver position, patch use, and pulmonary function tests (PFTs) (forced expiratory volume at 1 second [FEV1] and forced vital capacity [FVC] expressed as mean % predicted + SD) were recorded. Read More

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http://dx.doi.org/10.1055/s-0038-1676586DOI Listing
February 2019
4 Reads

Reply.

J Pediatr 2018 Dec 14. Epub 2018 Dec 14.

Department of Pediatric General Thoracic and Fetal Surgery Children's Hospital of Philadelphia Perelman School of Medicine at the University of Pennsylvania Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jpeds.2018.11.033DOI Listing
December 2018
1 Read

Expression of Nitric Oxide Synthase Interacting Protein (NOSIP) is Decreased in the Pulmonary Vasculature of Nitrofen-Induced Congenital Diaphragmatic Hernia.

Eur J Pediatr Surg 2019 Feb 10;29(1):102-107. Epub 2018 Dec 10.

Our Lady's Children's Hospital, National Children's Research Centre, Crumlin, Dublin, Ireland.

Introduction:  Persistent pulmonary hypertension (PPH) is a major cause of morbidity and mortality in newborns with congenital diaphragmatic hernia (CDH). PPH is characterized by increased vascular resistance and smooth muscle cell (SMC) proliferation, leading to obstructive changes in the pulmonary vasculature. Nitric oxide (NO), generated by endothelial NO synthase (eNOS), is an important regulator of vascular tone and plays a key role in pulmonary vasodilatation. Read More

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http://dx.doi.org/10.1055/s-0038-1675772DOI Listing
February 2019
4 Reads

On the feasibility of accessing acute pain-related facial expressions in the human fetus and its potential implications: a case report.

Pain Rep 2018 Sep-Oct;3(5):e673. Epub 2018 Jul 31.

Pain Center, Department of Neurology, University of São Paulo, São Paulo, Brazil.

Introduction: Although pain facial assessment is routinely performed in term and preterm newborns by the use of facial expression-based tools such as the Neonatal Facial Coding System, the assessment of pain during the intrauterine life has not been extensively explored.

Objective: Describe for the first time, an experimental model to assess and quantify responses due to acute pain in fetuses undergoing anaesthesia for intrauterine surgery recorded by high-resolution 4D ultrasound machines.

Methods/results-case Report: A 33-year-old pregnant woman had congenital left diaphragmatic hernia of poor prognosis diagnosed, and her fetus was treated by fetoscopic endotracheal occlusion. Read More

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http://dx.doi.org/10.1097/PR9.0000000000000673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181467PMC
July 2018
3 Reads

De novo variants in congenital diaphragmatic hernia identify MYRF as a new syndrome and reveal genetic overlaps with other developmental disorders.

PLoS Genet 2018 12 10;14(12):e1007822. Epub 2018 Dec 10.

Department of Systems Biology, Columbia University Medical Center, New York, New York, United States of America.

Congenital diaphragmatic hernia (CDH) is a severe birth defect that is often accompanied by other congenital anomalies. Previous exome sequencing studies for CDH have supported a role of de novo damaging variants but did not identify any recurrently mutated genes. To investigate further the genetics of CDH, we analyzed de novo coding variants in 362 proband-parent trios including 271 new trios reported in this study. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301721PMC
December 2018
3 Reads

Intra-amniotic Sildenafil Treatment Modulates Vascular Smooth Muscle Cell Phenotype in the Nitrofen Model of Congenital Diaphragmatic Hernia.

Sci Rep 2018 Dec 5;8(1):17668. Epub 2018 Dec 5.

Department of Pediatric General and Thoracic Surgery, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

The etiology of pulmonary vascular abnormalities in CDH is incompletely understood. Studies have demonstrated improvement in pulmonary vasculature with prenatal therapy in animal models. We hypothesize that prenatal sildenafil may attenuate defective pulmonary vascular development via modulation of vSMC phenotype from undifferentiated, proliferative phenotype to differentiated, contractile phenotype. Read More

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http://dx.doi.org/10.1038/s41598-018-34948-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6281652PMC
December 2018
3 Reads

Inter- and Intra-rater Reliability of A Grading System for Congenital Diaphragmatic Hernia Defect Size.

J Surg Res 2019 Jan 17;233:82-87. Epub 2018 Aug 17.

Division of Pediatric Surgery, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana. Electronic address:

Background: The Congenital Diaphragmatic Hernia Study Group (CDHSG) registry is a multi-institutional tool to track outcomes of patients with CDH. The CDHSG asks surgeons to categorize diaphragmatic defect sizes as type A-D based on published guidelines. The reported size of the defect has been correlated with patient outcomes, but the reliability of this system has never been studied. Read More

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http://dx.doi.org/10.1016/j.jss.2018.07.045DOI Listing
January 2019
3 Reads

Respiratory syncytial virus prophylaxis in infants with congenital diaphragmatic hernia in the CARESS registry (2005-2017).

Clin Infect Dis 2018 Nov 30. Epub 2018 Nov 30.

Medical Outcomes and Research in Economics (MORE®) Research Group, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

Background: Infants with congenital diaphragmatic hernia (CDH) are at increased risk of respiratory morbidity from recurrent respiratory tract infections including those from respiratory syncytial virus (RSV). Data from prospective studies on RSV prophylaxis in CDH infants are limited. The objective was to determine the risk of respiratory illness- and RSV-related hospitalizations (RIH and RSVH, respectively) among infants prophylaxed for CDH, standard indications (SI), and those without increased risk (NR). Read More

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http://dx.doi.org/10.1093/cid/ciy1010DOI Listing
November 2018
4 Reads

ANNALS EXPRESS: Hematopoietic alterations in neonates with congenital diaphragmatic hernia receiving extracorporeal membrane oxygenation support.

Ann Clin Biochem 2018 Dec 4:4563218820052. Epub 2018 Dec 4.

Department of Neonatology and Pediatric Critical Care Medicine, University of Bonn Children's Hospital.

Background Extracorporeal membrane oxygenation procedure (ECMO) has been established in the therapy of respiratory insufficient infants with congenital diaphragmatic hernia (CDH). In CDH newborns, a delay in transfer to an ECMO center is associated with a sharp increase in mortality. Predictive factors for ECMO support are urgently needed. Read More

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http://dx.doi.org/10.1177/0004563218820052DOI Listing
December 2018
6 Reads

Longitudinal changes in lung size and intrapulmonary-artery Doppler during the second half of pregnancy in fetuses with congenital diaphragmatic hernia.

Prenat Diagn 2019 Jan 21;39(1):45-51. Epub 2018 Dec 21.

Department of Fetal Surgery, Children and Women's Specialty Hospital of Queretaro, Queretaro, Mexico Fetal Medicine Mexico Foundation, Queretaro, Mexico.

Objectives: The objectives of the study are to evaluate longitudinal changes in lung size and intrapulmonary-artery (IPa) Doppler in fetuses with congenital diaphragmatic hernia (CDH) and assess their contribution in predicting neonatal survival.

Methods: The observed/expected lung-to-head ratio (O/E-LHR) and IPa-pulsatility index (PI) and peak early diastolic reversed flow (PEDRF) were evaluated in a cohort of left-sided CDH fetuses managed expectantly during pregnancy. Longitudinal changes were analyzed by multilevel analysis, and their value to predict survival using the multiple logistic regression and decision-tree analysis was assessed. Read More

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http://doi.wiley.com/10.1002/pd.5401
Publisher Site
http://dx.doi.org/10.1002/pd.5401DOI Listing
January 2019
8 Reads

Vascular and ventilatory mechanical responses in three different stages of pulmonary development in the rabbit model of congenital diaphragmatic hernia 1.

Acta Cir Bras 2018 Oct;33(10):879-888

Associate Professor, Head, Department of Surgery and Anatomy, Laboratory of Experimental Fetal Surgery, Department of Surgery and Anatomy, Ribeirao Preto Medical School, USP, Ribeirao Preto-SP, Brazil. Scientific and intellectual content of the study, manuscript preparation, critical revision, final approval.

Purpose: To evaluate the vascular ventilatory response in different stages of lung development and to compare them to the neonates with congenital diaphragmatic hernia (CDH) in a rabbit model.

Methods: New Zealand rabbits were divided into 8 groups (n=5): E25, E27, E30, and CDH. All groups were ventilated on a FlexiVent (Scireq, Montreal, QC, Canada), compounding the other 4 groups. Read More

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http://dx.doi.org/10.1590/s0102-865020180100000002DOI Listing
October 2018
2 Reads

A Multimodality Navigation System for Endoscopic Fetal Surgery: A Phantom Case Study for Congenital Diaphragmatic Hernia.

Surg Innov 2018 Nov 28:1553350618813244. Epub 2018 Nov 28.

2 King's College Hospital, Fetal Medicine Research Institute, London, UK.

This article presents a multi-modality tracking and navigation system achieved by merging optical tracking and ultrasound imaging into a novel navigation software to help in surgical pre-planning and real-time target setting and guidance. Fetal surgeries require extensive experience in coordination of hand-eye-ultrasound-surgical equipment, knowledge, and precise assessment of relative anatomy. While there are navigation systems available for similar constrained working spaces in arthroscopic and cardiovascular procedures, fetal minimally invasive surgery does not yet have a dedicated navigation platform capable of supporting robotic instruments that can be adapted to the set of unique procedures. Read More

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http://dx.doi.org/10.1177/1553350618813244DOI Listing
November 2018
4 Reads

Imaging of thoracic hernias: types and complications.

Insights Imaging 2018 Dec 27;9(6):989-1005. Epub 2018 Nov 27.

Imaging Science, University of Rochester Medical Center, 601, Elmwood Avenue, Rochester, NY, 14642, USA.

Thoracic hernias are characterised by either protrusion of the thoracic contents outside their normal anatomical confines or extension of the abdominal contents within the thorax. Thoracic hernias can be either congenital or acquired in aetiology. They can occur at the level of the thoracic inlet, chest wall or diaphragm. Read More

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http://dx.doi.org/10.1007/s13244-018-0670-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269341PMC
December 2018
3 Reads