7,770 results match your criteria Diaphragmatic Hernias Congenital


Case report: anaesthetic and surgical management of a diaphragmatic rupture with tension pneumothorax and iatrogenic bowel perforation in an undiagnosed Bochdalek hernia patient.

BMC Anesthesiol 2022 Jun 24;22(1):195. Epub 2022 Jun 24.

Division of Anaesthesiology and Perioperative Medicine, Singapore General Hospital, Block 5 Level 2, Outram Road, Singapore, 169608, Singapore.

Background: Congenital diaphragmatic defects are rare, with most cases presenting in childhood. Diagnosis in adulthood is usually incidental or when symptoms develop. We present a case of a strangulated Bochdalek hernia complicated by possible tension pneumothorax and iatrogenic bowel injury in a healthy young male. Read More

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Peritoneopericardial diaphragmatic hernia in a healthy adult feline (): diagnosis to surgical treatment - Case report.

Rev Bras Med Vet 2021 23;43:e001820. Epub 2021 Mar 23.

Veterinarian, DSc. DMCV, IV, UFRRJ, Campus Seropédica, RJ, Brasil.

Peritoneopericardial diaphragmatic hernia (PPDH) is a communication between the abdomen and the pericardial sac generated by congenital anomalies triggered during diaphragmatic and pericardial development. This report aimed to present the case of an adult, mixed-breed cat, affected by PPDH, focusing on the period from diagnosis to successful surgical correction. The patient had a capricious appetite and weight loss for about four months and started, at the end of this period, a state of apathy. Read More

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Parent-Reported Perceived Cognitive Functioning Identifies Cognitive Problems in Children Who Survived Neonatal Critical Illness.

Children (Basel) 2022 Jun 16;9(6). Epub 2022 Jun 16.

Department of Pediatric Surgery and Intensive Care, Erasmus MC Sophia Children's Hospital, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.

Children with congenital anatomical foregut anomalies and children treated with neonatal extracorporeal membrane oxygenation (ECMO) are at risk for neurocognitive morbidities. We evaluated the association between the parent-reported pediatric perceived cognitive functioning (PedsPCF) questionnaire and the parent-reported behavior rating inventory of executive function (BRIEF) as well as neuropsychological assessments (NPA). We included 8-, 12- and 17-year-old participants who had joined a prospective follow-up program between 2017 and 2019. Read More

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Long-Term Outcomes of Congenital Diaphragmatic Hernia: Report of a Multicenter Study in Japan.

Children (Basel) 2022 Jun 8;9(6). Epub 2022 Jun 8.

Department of Pediatric Surgery, Osaka Women's and Children's Hospital, Izumi 594-1101, Japan.

Background: Treatment modalities for neonates with congenital diaphragmatic hernia (CDH) have greatly improved in recent years, with a concomitant increase in survival. However, long-term outcomes restrict the identification of optimal care pathways for CDH survivors in adolescence and adulthood. Therefore, we evaluated the long-term outcomes within the Japanese CDH Study Group (JCDHSG). Read More

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High insertion of the right diaphragm complicated with congenital diaphragmatic hernia: A case report of rare thoracoscopic findings.

Asian J Endosc Surg 2022 Jun 20. Epub 2022 Jun 20.

Department of Pediatric Surgery, Research Field in Medical and Health Sciences, Medical and Dental Area, Research and Education Assembly, Kagoshima University, Kagoshima, Japan.

We encountered a case of high insertion of the right diaphragm complicated with congenital diaphragmatic hernia that was diagnosed based on thoracoscopic findings. A full-term male baby was suspected of having right congenital diaphragmatic hernia or diaphragmatic eventration on postnatal imaging. He only had episodes of mild but prolonged symptoms following upper respiratory tract infection and his course was otherwise uneventful during outpatient monitoring. Read More

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The role of bedside functional echocardiography in the assessment and management of pulmonary hypertension.

Semin Fetal Neonatal Med 2022 Jun 14:101366. Epub 2022 Jun 14.

Division of Neonatology, Sidra Medicine, Doha, Qatar; Durham University, United Kingdom. Electronic address:

Pulmonary hypertension is an emergency in neonatal intensive care units with high morbidity and mortality. Its timely assessment and management is crucial for intact survival. Over the last couple of decades, there have been significant advances in management and techniques, which have resulted in improved survival. Read More

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CA125: a novel cardiac biomarker for infants with congenital diaphragmatic hernia.

Pediatr Res 2022 Jun 15. Epub 2022 Jun 15.

Department of Neonatology and Pediatric Intensive Care Medicine, University Children's Hospital Bonn, Bonn, Germany.

Background: The carbohydrate antigen 125 (CA125) was proven as a robust biomarker for risk stratification in adults with heart failure. This is the first study analyzing CA125 in a cohort of infants with congenital diaphragmatic hernia (CDH).

Methods: Sixty-eight infants with CDH, treated at the University Children's Hospital Bonn (Germany), between January 2018 and February 2021, were prospectively enrolled for analysis. Read More

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Survival and Neurodevelopmental Outcomes in Congenital Diaphragmatic Hernia Patients with Single versus Repeat ECMO Runs.

Am J Perinatol 2022 Jun 16. Epub 2022 Jun 16.

Pediatrics, Division of Newborn Medicin, Washington University in St Louis, St Louis, United States.

Objective: We describe the survival and neurodevelopmental outcomes of congenital diaphragmatic hernia (CDH) patients who received single and repeat ECMO.

Study Design: A retrospective single-center study comparing neurodevelopmental outcomes in CDH patients who were managed without ECMO, one ECMO run, and those who received two ECMO runs. Neurodevelopmental testing was performed utilizing the Bayley Scales of Infant Development-III. Read More

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Response to: "Congenital diaphragmatic hernia: What about respiratory mechanics?"

Authors:
Theodore Dassios

Eur J Pediatr 2022 Jun 13. Epub 2022 Jun 13.

Neonatal Intensive Care Centre, King's College Hospital, 4Th Floor Golden Jubilee Wing, Denmark Hill, London, SE5 9RS, UK.

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Congenital diaphragmatic hernia: what about respiratory mechanics?

Eur J Pediatr 2022 Jun 13. Epub 2022 Jun 13.

Department of Intensive Care Medicine, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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Diaphragmatic Hernia in a Preterm with Congenital Heart Defects with Successful Outcome: A Case Report.

JNMA J Nepal Med Assoc 2022 Jun 1;60(250):565-568. Epub 2022 Jun 1.

Neonatology Unit, Department of Pediatrics, Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.

Congenital diaphragmatic hernia is an anatomical defect of the diaphragm that is often associated with serious cardiopulmonary complications. It can also be associated with many other problems like multi systemic anomalies, chromosomal aneuploidy and prematurity. Of these, cardiac defects, liver herniation and prematurity seem to have a pivotal role in affecting the outcomes of repair. Read More

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Two unusual fat-containing mediastinal entities: Pearls and pitfalls in imaging of Morgagni hernia and fat necrosis.

Semin Ultrasound CT MR 2022 Jun 5;43(3):267-278. Epub 2022 Feb 5.

Department of Thoracic Imaging, University of Texas MD Anderson Cancer Center, Houston, TX.

This review focuses on 2 fat-containing entities in the mediastinum that may raise a diagnostic challenge: Morgagni's hernia and Epipericardial (mediastinal) fat necrosis. Familiarity with the typical imaging findings of these 2 entities is vital for the radiologist to recognize and accurately characterize unusual mediastinal pathological conditions. Read More

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Echocardiographic Assessment of Pulmonary Hypertension in Neonates with Congenital Diaphragmatic Hernia Using Pulmonary Artery Flow Characteristics.

J Clin Med 2022 May 27;11(11). Epub 2022 May 27.

Department of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, 53113 Bonn, Germany.

Background: Assessment of pulmonary hypertension (PH) is essential in neonates with congenital diaphragmatic hernia (CDH). Echocardiography is widely established to quantify PH severity, but currently used parameters have inherent limitations. The aim of our study was to investigate the prognostic utility of the index of the pulmonary artery acceleration time to the right ventricular ejection time (PAAT:ET) in CDH neonates assessed using echocardiography. Read More

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Postnatal care setting and survival after fetoscopic tracheal occlusion for severe congenital diaphragmatic hernia: A systematic review and meta-analysis.

J Pediatr Surg 2022 May 19. Epub 2022 May 19.

Department of Gynecology and Obstetrics, Johns Hopkins Center for Fetal Therapy, Johns Hopkins University School of Medicine, 600N. Wolfe Street, Baltimore 21287, MD, United States. Electronic address:

Background: Fetoscopic endoluminal tracheal occlusion (FETO) was recently shown to improve postnatal survival in a multicenter, randomized controlled trial of infants with severe congenital diaphragmatic hernia (CDH). However, the external validity of this study remains unclear given a lack of standardization in postnatal management approaches. The purpose of this study was to evaluate the impact of an integrated prenatal and postnatal care setting on survival outcomes in severe CDH after FETO. Read More

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Lung to thorax transverse area ratio as a predictor of neurodevelopmental outcomes in fetuses with congenital diaphragmatic hernia.

Early Hum Dev 2022 Jun 6;170:105598. Epub 2022 Jun 6.

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Introduction: Infants with congenital diaphragmatic hernia (CDH) are at risk of neurodevelopmental disabilities. This study aimed to investigate the association between lung to thorax transverse area ratio (LTR) and neurodevelopmental outcomes at 3 years of age in fetuses with CDH.

Methods: We performed a retrospective study of infants with prenatally diagnosed isolated left-sided CDH born in Kyushu University Hospital between 2008 and 2016. Read More

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New challenges of fetal therapy in Japan.

J Obstet Gynaecol Res 2022 Jun 8. Epub 2022 Jun 8.

Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.

Aim: To review new challenges of fetal therapy in Japan after the establishment of four existing fetal therapies as standard prenatal care with National Health Insurance coverage over the past 20 years.

Methods: Reported studies and our current research activities related to four fetal therapies newly performed in Japan were reviewed.

Results: Fetoscopic endoluminal tracheal occlusion (FETO) for congenital diaphragmatic hernia (CDH) aims to occlude the trachea using a detachable balloon to promote lung growth. Read More

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Extracellular Vesicles as Therapy for CDH-associated Pulmonary Hypoplasia: Extra! Extra! Read All About Autophagy!

Am J Respir Crit Care Med 2022 Jun 8. Epub 2022 Jun 8.

Children's Hospital Los Angeles, Los Angeles, California, United States.

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Transcatheter Occlusion of a Patent Ductus Arteriosus for a Symptomatic Left-to-Right Shunt.

Cureus 2022 May 4;14(5):e24733. Epub 2022 May 4.

Surgery, University of Illinois Hospital, Chicago, USA.

Congenital diaphragmatic hernias (CDH) can induce life-threatening pulmonary hypertension and right heart failure. The patent ductus arteriosus (PDA) is often maintained in CDH to allow for decompression into the systemic circulation. However, if the PDA becomes hemodynamically significant, PDA closure may be indicated. Read More

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Autophagy is Impaired in Fetal Hypoplastic Lungs and Rescued by Administration of Amniotic Fluid Stem Cell Extracellular Vesicles.

Am J Respir Crit Care Med 2022 Jun 7. Epub 2022 Jun 7.

The Hospital for Sick Children, 7979, Developmental and Stem Cell Biology Program, Toronto, Ontario, Canada.

Rationale: Pulmonary hypoplasia secondary to congenital diaphragmatic hernia (CDH) is characterized by reduced branching morphogenesis, which is responsible for poor clinical outcomes. Administration of amniotic fluid stem cell extracellular vesicles (AFSC-EVs) rescues branching morphogenesis in rodent fetal models of pulmonary hypoplasia. Herein, we hypothesized that AFSC-EVs exert their regenerative potential by affecting autophagy, a process required for normal lung development. Read More

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Impact of the COVID-19 pandemic on congenital diaphragmatic hernia patients: a single-center retrospective study.

Pediatr Surg Int 2022 Jun 7. Epub 2022 Jun 7.

Department of Neonatal Surgery, Children's Hospital of Capital Institute of Pediatrics, Graduate School of Peking Union Medical College, Beijing, China.

Purpose: To investigate the impact of COVID-19 on the treatment of children with congenital diaphragmatic hernia (CDH).

Methods: We retrospectively collected and compared the data of patients with CDH admitted between January 1, 2020 and December 31, 2021(study group) with the CDH patients admitted before the pandemic between January 1, 2018 and December 31, 2019 (control group).

Results: During the pandemic, 41 patients with CDH diagnosed prenatally were transferred to our hospital, and 40 underwent surgical repair. Read More

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Evidence-based genetic testing for individuals with congenital diaphragmatic hernia (CDH).

J Pediatr 2022 Jun 3. Epub 2022 Jun 3.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Texas Children's Hospital, Houston, TX 77030; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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Congenital diaphragmatic hernia in adults: a decade of experience from a single tertiary center.

Scand J Gastroenterol 2022 Jun 4:1-5. Epub 2022 Jun 4.

Department of Surgery, Faculty of Medicine, Helsinki University, Helsinki, Finland.

Introduction: Congenital diaphragmatic hernias (CDHs) in adults remain rare, with limited data on them available. However, CDHs can cause respiratory and gastrointestinal symptoms in adults, even resulting in the strangulation of the bowel when incarcerated. Here, we aimed to analyze surgical outcomes among adult patients. Read More

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Acquired Morgagni hernia following coronary artery bypass graft (CABG) with successful robotic repair of hernia.

Int J Surg Case Rep 2022 May 4;94:107164. Epub 2022 May 4.

Esophageal Institute, Department of Surgery, Allegheny Health Network, Pittsburgh, PA, United States; Department of Surgery, Drexel University, Philadelphia, PA, United States.

Introduction And Importance: Morgagni hernia is an uncommon type of diaphragmatic hernia and commonly presents as a congenital disease. Acquired Morgagni hernias following open cardiac surgery are exceedingly rare and only reported in the pediatric population.

Case Presentation: The patient is a 70-year-old female who presented with complaints of shortness of breath and cough one year following a coronary artery bypass graft (CABG). Read More

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Small Bowel Obstruction After Neonatal Repair of Congenital Diaphragmatic Hernia-Incidence and Risk-Factors Identified in a Large Longitudinal Cohort-Study.

Front Pediatr 2022 17;10:846630. Epub 2022 May 17.

Department of Pediatric Surgery, University Children's Hospital Mannheim, University of Heidelberg, Mannheim, Germany.

Objective: In patients with a congenital diaphragmatic hernia (CDH), postoperative small bowel obstruction (SBO) is a life-threatening event. Literature reports an incidence of SBO of 20% and an association with patch repair and ECMO treatment. Adhesions develop due to peritoneal damage and underly various biochemical and cellular processes. Read More

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[Management of congenital diaphragmatic hernia in sub-Saharan Africa: experience in the Albert Royer National Children's Hospital Center, Senegal].

Pan Afr Med J 2022 8;41:185. Epub 2022 Mar 8.

Service de Chirurgie Pédiatrique, Hôpital d'Enfants Alber Royer, Université Cheikh Anta Diop, Dakar, Sénégal.

Introduction: congenital diaphragmatic hernia has been rarely reported in Africa. It can manifests early or late. Prognosis mainly depends on associated malformations. Read More

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Congenital diaphragmatic hernia.

Authors:

Nat Rev Dis Primers 2022 06 1;8(1):36. Epub 2022 Jun 1.

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Congenital diaphragmatic hernia.

Nat Rev Dis Primers 2022 06 1;8(1):37. Epub 2022 Jun 1.

Department of Surgery, Division of Paediatric Surgery, Paediatrics & Child Health, Physiology & Pathophysiology, University of Manitoba, Winnipeg, Manitoba, Canada.

Congenital diaphragmatic hernia (CDH) is a rare birth defect characterized by incomplete closure of the diaphragm and herniation of fetal abdominal organs into the chest that results in pulmonary hypoplasia, postnatal pulmonary hypertension owing to vascular remodelling and cardiac dysfunction. The high mortality and morbidity rates associated with CDH are directly related to the severity of cardiopulmonary pathophysiology. Although the aetiology remains unknown, CDH has a polygenic origin in approximately one-third of cases. Read More

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Lung ultrasound in Italian neonatal intensive care units: A national survey.

Pediatr Pulmonol 2022 May 30. Epub 2022 May 30.

Department of Neurosciences Psychology Drug Research and Child Health, Careggi University Hospital of Florence, Florence, Italy.

Introduction: Lung ultrasound (LU) is a noninvasive, bedside imaging technique that is attracting growing interest in the evaluation of neonatal respiratory diseases. We conducted a nationwide survey of LU usage in Italian neonatal intensive care units (NICUs).

Methods: A structured questionnaire was developed and sent online to 114 Italian NICUs from June to September 2021. Read More

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Genetically Modified Mouse Models of Congenital Diaphragmatic Hernia: Opportunities and Limitations for Studying Altered Lung Development.

Front Pediatr 2022 13;10:867307. Epub 2022 May 13.

Beacon Hospital, University College Dublin, Dublin, Ireland.

Congenital diaphragmatic hernia (CDH) is a relatively common and life-threatening birth defect, characterized by an abnormal opening in the primordial diaphragm that interferes with normal lung development. As a result, CDH is accompanied by immature and hypoplastic lungs, being the leading cause of morbidity and mortality in patients with this condition. In recent decades, various animal models have contributed novel insights into the pathogenic mechanisms underlying CDH and associated pulmonary hypoplasia. Read More

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