53,798 results match your criteria Diaphragm Disorders


Intra-vessel heterogeneity establishes enhanced sites of macromolecular leakage downstream of laminin α5.

Cell Rep 2021 Jun;35(12):109268

Beijer and Science for Life Laboratories, Department of Immunology, Genetics and Pathology, Uppsala University, Dag Hammarskjöldsv 20, 751 85 Uppsala, Sweden. Electronic address:

Endothelial cells display heterogeneous properties based on location and function. How this heterogeneity influences endothelial barrier stability both between and within vessel subtypes is unexplored. In this study, we find that endothelial cells exhibit heterogeneous barrier properties on inter-organ and intra-vessel levels. Read More

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[Carotid bulbe diaphragm].

Rev Prat 2021 Jan;71(1):73

Service de radiologie, CHU Mohamed-VI, Oujda, Maroc.

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January 2021

Leukocytes are not Reliable in Predicting Possible Diaphragmatic Injury in Patients with Penetrating Left Thoracoabdominal Stab Wounds.

World J Surg 2021 Jun 23. Epub 2021 Jun 23.

Department of General Surgery, Umraniye Training and Research Hospital, Adem Yavuz street No. 1, Umraniye, Istanbul, Turkey.

Background: The diaphragm is injured in approximately one-third of penetrating left thoracoabdominal stab wounds. Diagnostic laparoscopy or thoracoscopy is performed to reveal the diaphragmatic injury. This study investigated whether leukocytes, leukocyte subgroups, platelets, the neutrophil-to-lymphocyte ratio (NLR), and the thrombocyte-to-lymphocyte ratio (PLR) can be used to detect diaphragm injury without the need for diagnostic laparoscopy. Read More

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Respiratory-swallow coordination in a rat model of chemoradiation.

Head Neck 2021 Jun 23. Epub 2021 Jun 23.

Department of Surgery-Otolaryngology, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Background: Chemoradiation treatment (CRT) for head and neck cancer (HNC) is associated with postswallow inhale events that elevate the risk of penetration/aspiration. The purpose of this study was to assess the validity of a rat model for investigating the effect of CRT on respiratory-swallow coordination.

Methods: Videofluoroscopic swallow study was performed on 10 Sprague-Dawley rats 3 months post-CRT (3 mg/kg Cisplatin, 10 fractions of 4. Read More

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Total parietal peritonectomy in primary debulking surgery for advanced ovarian cancer.

Gynecol Oncol Rep 2021 Aug 11;37:100805. Epub 2021 Jun 11.

Department of Obstetrics and Gynecology, The Jikei University School of Medicine, 3-19-18 Nishishinbashi, Minato-ku, Tokyo, Japan.

The object of this study is to evaluate the clinical safety and efficacy of total parietal peritonectomy (TPP) in primary debulking surgery (PDS) for advanced ovarian cancer. This retrospective single-center study analyzed 16 patients with FIGO stages IIIC-IVB epithelial ovarian cancer who underwent TPP in PDS and achieved macroscopically complete resection between April 2015 and June 2016. The median age of 16 patients was 52. Read More

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Common Carotid Artery Diaphragm presenting as transient syncope.

Radiol Case Rep 2021 Aug 8;16(8):2050. Epub 2021 Jun 8.

Department of Emergency Radiology, Ibn Sina Hospital, 19 Rue Camelia, Secteur 9, Rabat Morocco.

Carotid diaphragm usually can cause artery stenosis essentially affecting the internal carotid artery (ICA) beyond the bulb segment.  Patients are often middle aged and the onset of symptoms typically begins with syncopes leading to ischemic stroke.  More than 50 cases have been reported in which all lesions showed as stenosis located in the ICA, in this article, we report a rare common carotid artery (CCA) diaphragm revealed in a 59 year-old female suffering from transient syncopes. Read More

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Improving outcomes of surgery in advanced infiltrative thymic tumours: the benefits of multidisciplinary approach.

Tumori 2021 Jun 22:3008916211023154. Epub 2021 Jun 22.

Department of Cardiac Surgery, Guy's Hospital London, London, UK.

Background: For stage III or IVa thymic tumours, a multimodality approach is recommended. The role of surgery is to achieve complete resection.

Aim: To present the outcomes of patients undergoing surgery for stage III or IVa thymoma. Read More

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Predicting reintervention after thoracic endovascular aortic repair of Stanford type B aortic dissection using machine learning.

Eur Radiol 2021 Jun 22. Epub 2021 Jun 22.

Department of Catheterization Lab, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106 Zhongshan Er Road, Guangzhou, 510080, People's Republic of China.

Objectives: To construct models for predicting reintervention after thoracic endovascular aortic repair (TEVAR) of Stanford type B aortic dissection (TBAD).

Methods: A total of 192 TBAD patients who underwent TEVAR were included; 68 (35.4%) had indications for reintervention. Read More

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Super-resolved local recruitment of CLDN5 to filtration slits implicates a direct relationship with podocyte foot process effacement.

J Cell Mol Med 2021 Jun 22. Epub 2021 Jun 22.

Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.

Under healthy conditions, foot processes of neighbouring podocytes are interdigitating and connected by an electron-dense slit diaphragm. Besides slit diaphragm proteins, typical adherens junction proteins are also found to be expressed at this cell-cell junction. It is therefore considered as a highly specialized type of adherens junction. Read More

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Malignant transformation of hepatic endometriosis: a case report and literature review.

BMC Womens Health 2021 06 21;21(1):249. Epub 2021 Jun 21.

Department of Pathology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, 110004, China.

Background: Extrapelvic endometriosis is defined as the presence of ectopic endometrial tissue in structures outside the pelvis. Although extra-pelvic endometriosis is generally considered benign conditions, malignant potential within endometriotic foci occurs even after definitive surgery. Malignant transformation of hepatic endometriosis is extremely rare. Read More

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Differential effects of acute cerebellectomy on cough in spontaneously breathing cats.

PLoS One 2021 21;16(6):e0253060. Epub 2021 Jun 21.

Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, United States of America.

The role of the cerebellum in controlling the cough motor pattern is not well understood. We hypothesized that cerebellectomy would disinhibit motor drive to respiratory muscles during cough. Cough was induced by mechanical stimulation of the tracheobronchial airways in anesthetized, spontaneously breathing adult cats (8 male, 1 female), and electromyograms (EMGs) were recorded from upper airway, chest wall, and abdominal respiratory muscles. Read More

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Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator.

J Gen Physiol 2021 Jul 21;153(7). Epub 2021 Jun 21.

Department of Physiology, Amsterdam University Medical Centers, Amsterdam, Netherlands.

Muscle ankyrin repeat protein 1 (MARP1) is frequently up-regulated in stressed muscle, but its effect on skeletal muscle function is poorly understood. Here, we focused on its interaction with the titin-N2A element, found in titin's molecular spring region. We show that MARP1 binds to F-actin, and that this interaction is stronger when MARP1 forms a complex with titin-N2A. Read More

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The immediate effect of thoracolumbar manipulation and diaphragmatic release on inspiratory muscle strength inhealthy smokers: A randomized clinical trial.

J Back Musculoskelet Rehabil 2021 Jun 18. Epub 2021 Jun 18.

Rehabilitation Department, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia.

Background: Diaphragmatic release technique and thoracolumbar manipulation have been found effective in restoring normal diaphragmatic movement in healthy and diseased populations. Smoking has deleterious effects on human systems, including the musculoskeletal system.

Objective: The current study aimed to investigate the immediate effects of diaphragmatic release technique and thoracolumbar manipulation on diaphragm muscle strength in healthy smokers. Read More

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Modeling the Glomerular Filtration Barrier and Intercellular Crosstalk.

Front Physiol 2021 2;12:689083. Epub 2021 Jun 2.

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

The glomerulus is a compact cluster of capillaries responsible for blood filtration and initiating urine production in the renal nephrons. A trilaminar structure in the capillary wall forms the glomerular filtration barrier (GFB), composed of glycocalyx-enriched and fenestrated endothelial cells adhering to the glomerular basement membrane and specialized visceral epithelial cells, podocytes, forming the outermost layer with a molecular slit diaphragm between their interdigitating foot processes. The unique dynamic and selective nature of blood filtration to produce urine requires the functionality of each of the GFB components, and hence, mimicking the glomerular filter has been challenging, though critical for various research applications and drug screening. Read More

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Recurrent Chylous Ascites Leading to Transudative Chylothorax Due to Bi-Ventricular Heart Failure.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211026144

Appalachian Regional Healthcare, Internal Medicine Residency Program, Harlan, KY, USA.

Chylothorax is a pleural effusion of >110 mg/dL of triglycerides with a milky appearance with transudative being rare. In this article, we present a case of transudative chylothorax with concurrent chylous ascites that is secondary to congestive heart failure (CHF). A 70-year-old male with CHF with ejection fraction of 10%, coronary artery disease status post coronary artery bypass graft, sleep apnea, chronic kidney disease stage 3, and chronic obstructive pulmonary disease presented with worsening abdominal distention, shortness of breath, and increased lower extremities edema. Read More

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Acute morphine blocks spinal respiratory motor plasticity via long- latency mechanisms that require toll-like receptor 4 signaling.

J Physiol 2021 Jun 18. Epub 2021 Jun 18.

Breathing Research and Therapeutics Center, University of Florida, Gainesville, FL, 32610.

While respiratory complications following opioid use are mainly mediated via activation of mu opioid receptors, long-latency off-target signaling via innate immune toll like receptor 4 (TLR4) may impair other essential elements of breathing control such as respiratory motor plasticity. In adult rats, pre-treatment with a single dose of morphine blocked long-term facilitation (LTF) of phrenic motor output via a long-latency TLR4-dependent mechanism. In the phrenic motor nucleus, morphine triggered TLR4-dependent activation of microglial p38 MAPK - a key enzyme that orchestrates inflammatory signaling and is known to undermine phrenic LTF. Read More

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Clinical findings and management of diaphragmatic rupture with hernia caused by safety body harness: A case report.

Ann Med Surg (Lond) 2021 Jun 29;66:102429. Epub 2021 May 29.

Digestive Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Gadjah Mada/Dr. Sardjito Hospital, 55281, Faculty of Medicine, Universitas Gadjah Mada/Dr Sardjito Hospital, Yogyakarta, Indonesia.

Introduction: Acute blunt traumatic diaphragmatic rupture (BTDR) caused by falling from a height is rare. Transabdominal diaphragmatic repair in an acute setting following BTDR requires good clinical decision-making and diagnostic tests.

Case Presentation: A 36-year-old male was involved in a work accident. Read More

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Unilateral diaphragm paralysis with COVID-19 infection.

BMJ Case Rep 2021 Jun 17;14(6). Epub 2021 Jun 17.

Department of Respiratory Medicine, Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool, UK.

Neurological complications are well described in SARS-CoV-2, but for the first time we report a case of unilateral diaphragm paralysis occurring early in mechanical ventilation for respiratory failure due to such an infection. The patient subsequently required tracheostomy and ventilator support for 37 days, and had increased breathlessness and an elevated diaphragm at clinic review 9 months later. Dynamic chest radiography demonstrated persistent diaphragm paralysis with an accompanying postural change in lung volumes, and he subsequently underwent surgical plication. Read More

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Urogenital fascia anatomy study in the inguinal region of 10 formalin-fixed cadavers: new understanding for laparoscopic inguinal hernia repair.

BMC Surg 2021 Jun 17;21(1):295. Epub 2021 Jun 17.

First Department of General Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710000, China.

Purpose: To investigate the urogenital fascia (UGF) anatomy in the inguinal region, to provide anatomical guidance for laparoscopic inguinal hernia repair (LIHR).

Methods: The anatomy was performed on 10 formalin-fixed cadavers. The peritoneum and its deeper fascial tissues were carefully dissected. Read More

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A Novel Coupled Piezoelectric Micromachined Ultrasonic Transducer Based on Piston Mode.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 Jun 17;PP. Epub 2021 Jun 17.

This paper presents a piezoelectric micromachined ultrasonic transducer (pMUT) modified with a piston diaphragm term as PD-pMUT (Piston Diaphragm pMUT). The transmission SPL and the frequency bandwidth of the modified transducer can be remarkably improved by adding a piston diaphragm on the central circular diaphragm. In this work, a lumped model, an acoustic resonance model, and an equivalent circuit model are established to study the multi-resonance mechanism. Read More

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Bilateral diaphragmatic paralysis and Lyme neuroborreliosis. Ten years of follow-up.

Medicina (B Aires) 2021 ;81(3):474-477

Instituto de Investigaciones Médicas Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina. E-mail:

Borrelia burgdorferi infection (Lyme disease) is one of the few identifiable causes of neuralgic amyotrophy. Bilateral diaphragmatic paralysis is considered rare in borreliosis, and the pattern of long-term recovery of diaphragm function is also uncertain. Transdiaphragmatic pressure is the gold standard for diagnosis of bilateral diaphragmatic paralysis, a study that has been reported on few occasions. Read More

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Diaphragmatic Paraganglioma in an Adolescent Male.

Cureus 2021 May 14;13(5):e15027. Epub 2021 May 14.

Internal Medicine Department, Grupo Interinstitucional de Medicina Interna (GIMI 1), Universidad Libre, Cali, COL.

Paragangliomas are an infrequent type of neuroendocrine tumor that commonly produces catecholamines. We describe a case of a 14-year-old male with a history of uncontrolled hypertension who presented to the emergency department with a headache, palpitations, and profuse sweating. Symptoms were explained by the presence of a catecholamine-producing paraganglioma located at the right diaphragm. Read More

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Physiological Effects of Intermittent Passive Exposure to Hypobaric Hypoxia and Cold in Rats.

Front Physiol 2021 31;12:673095. Epub 2021 May 31.

Secció de Fisiologia, Departament de Biologia Cel.lular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.

The benefits of intermittent hypobaric hypoxia (IHH) exposure for health and its potential use as a training tool are well-documented. However, since hypobaric hypoxia and cold are environmental factors always strongly associated in the biosphere, additive or synergistic adaptations could have evolved in animals' genomes. For that reason, the aim of the present study was to investigate body composition and hematological and muscle morphofunctional responses to simultaneous intermittent exposure to hypoxia and cold. Read More

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Distinct modulation of tracheal and laryngopharyngeal cough via superior laryngeal nerve in cat.

Respir Physiol Neurobiol 2021 Jun 10;293:103716. Epub 2021 Jun 10.

Institute of Medical Biophysics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Malá Hora 4, 036 01 Martin, Slovak Republic.

Unilateral and bilateral cooling and bilateral transsection of the superior laryngeal nerve (SLN) were employed to modulate mechanically induced tracheobronchial (TB) and laryngopharyngeal (LPh) cough in 12 anesthetized cats. There was little effect of SLN block or cut on TB. Bilateral SLN cooling reduced the number of LPh (<50 %, p < 0. Read More

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PCR-based detection of Toxoplasma gondii from cattle in southern Iran.

Comp Immunol Microbiol Infect Dis 2021 Aug 2;77:101677. Epub 2021 Jun 2.

Jahrom City Veterinary Office, Jahrom, Iran.

Objective: Toxoplasma gondii is a protozoan parasite that is widely prevalent in most warm-blooded vertebrates. Humans mainly become infected by eating raw or undercooked meat. This study was designed to investigate the infection of cattle with T. Read More

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Neurally adjusted ventilatory assist in neonates with congenital diaphragmatic hernia.

J Perinatol 2021 Jun 10. Epub 2021 Jun 10.

Division of Neonatology, Children's Mercy Kansas City, Kansas City, MO, USA.

Objective: To measure short-term outcomes of neonates with congenital diaphragmatic hernia (CDH) while on Neurally Adjusted Ventilator Assist (NAVA), and to measure the impact of a congenitally abnormal diaphragm on NAVA ventilator indices.

Study Design: First, we conducted a retrospective-cohort analysis of 16 neonates with CDH placed on NAVA over a treatment period of 72 h. Second, we performed a case-control study comparing NAVA level and Edi between neonates with CDH and those without CDH. Read More

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[Application progress of ultrasound monitoring of diaphragm function in clinic].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):638-640

Department of Anesthesiology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China.

In recent years, point of care ultrasound (POCUS) has developed rapidly in the fields of anesthesia and critical care. POCUS is widely used in clinic to monitor the function of human tissues and organs such as the heart, lungs, and diaphragm due to its visual, non-invasive, portable, and repeatable characters at the bedside. Diaphragm is an important structure to maintain respiratory function. Read More

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Diaphragm neurostimulation during mechanical ventilation reduces atelectasis and transpulmonary plateau pressure, preserving lung homogeneity and PaO2/FiO2.

J Appl Physiol (1985) 2021 Jun 10. Epub 2021 Jun 10.

grid.61971.38Simon Fraser University, British Columbia, Canada.

Tidal volume delivered by mechanical ventilation to a sedated patient is distributed in a non-physiological pattern, causing atelectasis (underinflation) and overdistension (overinflation). Activation of the diaphragm during mechanical ventilation provides a way to reduce atelectasis and alveolar inhomogeneity, protecting the lungs from ventilator-induced lung injury while also protecting the diaphragm by preventing ventilator-induced diaphragm dysfunction. We studied the hypothesis that diaphragm contractions elicited by transvenous phrenic nerve stimulation, delivered in synchrony with volume-control ventilation, would reduce atelectasis and lung inhomogeneity in a healthy, normal-lung pig model. Read More

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Silent Sigmoid Colon Diverticular Perforation: A Case Report.

Cureus 2021 May 8;13(5):e14900. Epub 2021 May 8.

Internal Medicine, Detroit Medical Center Sinai-Grace Hospital, Detroit, USA.

Colonic perforation is associated with high mortality rates, and it requires prompt diagnosis and intervention to ensure favorable patient outcomes. The condition usually presents with typical peritoneal signs and symptoms, but atypical presentations can be a diagnostic challenge. In this report, we present a case of sigmoid diverticulosis perforation in an elderly patient who had no symptoms after the perforation developed. Read More

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Enhancement of Transmitting Sensitivity of Piezoelectric Micromachined Ultrasonic Transducers By Electrode Design.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 Jun 9;PP. Epub 2021 Jun 9.

This paper investigates the dependence of transmitting sensitivity on the top electrode design of piezoelectric micromachined ultrasonic transducers (PMUTs). Two typical top electrodes, namely inner electrode (IE) and outer electrode (OE), are designed and fabricated. The measured transmitting velocities of the fabricated PMUTs at resonance under a drive voltage of 5 Vp-p (peak-to-peak) are 15. Read More

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