Search Our Scientific Publications & Authors

Glia 2018 Dec 11. Epub 2018 Dec 11.

Department of Neuroscience, Vickie and Jack Farber Institute for Neuroscience, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania.

Stem/progenitor cell transplantation delivery of astrocytes is a potentially powerful strategy for spinal cord injury (SCI). Axon extension into SCI lesions that occur spontaneously or in response to experimental manipulations is often observed along endogenous astrocyte "bridges," suggesting that augmenting this response via astrocyte lineage transplantation can enhance axon regrowth. Given the importance of respiratory dysfunction post-SCI, we transplanted glial-restricted precursors (GRPs)-a class of lineage-restricted astrocyte progenitors-into the C2 hemisection model and evaluated effects on diaphragm function and the growth response of descending rostral ventral respiratory group (rVRG) axons that innervate phrenic motor neurons (PhMNs). Read More

J Cardiol Cases 2014 Jan 13;9(1):29-31. Epub 2013 Dec 13.

Department of Cardiology, KKR Sapporo Medical Center, Hiragishi 1-6, Toyohira-ku, Sapporo, Hokkaido 062-0931, Japan.

A 69-year-old woman with exertional dyspnea was referred emergently to our hospital for further evaluation. Transthoracic echocardiography showed severe mitral valve regurgitation and moderate tricuspid regurgitation, which were thought to be the main cause of her heart failure. An electrocardiogram showed paroxysmal atrial fibrillation. Read More

J Cardiol Cases 2014 Aug 19;10(2):66-68. Epub 2014 Jun 19.

Department of Cardiovascular Surgery, Hacettepe University School of Medicine, Ankara, Turkey.

Complications of percutaneous pericardial catheter insertion for pericardial effusion are rare. We describe a rare complication of percutaneous pericardial catheter insertion that penetrated the stomach and diaphragm before getting into the pericardial sac in a patient with lymphoma. The misplaced catheter was extracted surgically and subxiphoid pericardial tube insertion with pleural pericardial window was performed. Read More

Pathologica 2018 Sep;110(2):116-120

Department of Pathology, University General Hospital of Catalonia, Sant Cugat del Vallès, Barcelona, Spain.

Bronchogenic cysts represent congenital malformations deriving from an abnormal development of the primitive foregut during embryogenesis. These lesions are rarely found and they are most frequently localized in the mediastinum, or in lung parenchyma. Intramuscular localization is extremely rare, especially within the diaphragm. Read More

Sensors (Basel) 2018 Dec 10;18(12). Epub 2018 Dec 10.

Neonatology, San Carlos Clinical Hospital, Madrid 28040, Spain.

This paper presents non-contact vital sign monitoring in neonates, based on image processing, where a standard color camera captures the plethysmographic signal and the heart and breathing rates are processed and estimated online. It is important that the measurements are taken in a non-invasive manner, which is imperceptible to the patient. Currently, many methods have been proposed for non-contact measurement. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13532

Department of Internal Medicine, Chonnam National University Medical School.

Rationale: Radiofrequency ablation (RFA) is a safe and effective local treatment modality with a low complication rate and is commonly used to treat hepatocellular carcinoma (HCC). The clinical outcome of RFA may be closely related to the location, size, and shape of index tumors, and major complications, including hemorrhage, liver abscess, infarction, visceral organ perforation, hemothorax, pneumothorax, tumoral seeding, and hepatic failure. Cardiac tamponade is a rare and serious life-threatening complication associated with RFA. Read More

J Neurosurg 2018 Nov 1:1-4. Epub 2018 Nov 1.

A carotid web is a shelf-like intraluminal filling defect typically arising from the posterolateral wall of the proximal internal carotid artery. It is recognized as a possible cause of ischemic stroke in young adults. However, its etiopathogenesis is controversial and remains to be fully elucidated. Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1041-1045

Department of Emergency Medicine, Hunan Provincial People's Hospital (the First Affiliated Hospital of Hunan Normal University), Hunan Key Laboratory of Critical and Critical Metabolomics, Changsha 410005, Hunan, China. Corresponding author: Han Xiaotong, Email:

Objective: To evaluate the diaphragm movement index of mechanical ventilation weaning patients by ultrosonography, and to explore its value for weaning.

Methods: Forty patients undergoing invasive mechanical ventilation for at least 48 hours admitted to emergency intensive care unit (EICU) of Hunan Provincial People's Hospital from September 2017 to February 2018 were enrolled. Low level pressure support ventilation (PSV) was used for spontaneous breathing test (SBT), and bedside M-mode ultrasonography was used to assess the diaphragm movement index of the patient within 1 hour of SBT, including the excursion of the diaphragm, diaphragmatic-rapid shallow breathing index (D-RSBI). Read More

BMC Cancer 2018 Dec 12;18(1):1243. Epub 2018 Dec 12.

Department of General, Visceral and Tumor Surgery, University Hospital of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.

Background: Collision tumors are rare cases with two different tumor entities growing synchronously. While adenocarcinoma of the pancreas is the most common pancreatic tumor with an incidence of 10 per 100.000, retroperitoneal liposarcoma remains very rare. Read More

Eur Respir J 2018 Dec 5. Epub 2018 Dec 5.

APHP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Département de Neurologie, Centre référent SLA, Paris, France.

Amyotrophic lateral sclerosis (ALS) patients show progressive respiratory muscle weakness leading to death from respiratory failure. However, there are no data on diaphragm histological changes in ALS patients and how they correlate with routine respiratory measurements.We collected 39 diaphragm biopsies concomitantly with laparoscopic insertion of intradiaphragmatic electrodes during a randomised controlled trial evaluating early diaphragm pacing in ALS (NCT01583088). Read More

J Acoust Soc Am 2018 Nov;144(5):2674

Ray W. Herrick Laboratories, Purdue University, 177 South Russell Street, West Lafayette, Indiana 47907-2099, USA.

The equivalent source methods (ESM) that have been developed to this point can generally be classified into two categories: one in which a relatively large number of lower order sources are fixed at various locations, and one in which a series of higher order sources are fixed at one location. The present work started with a model in the latter category, but the individual sources were then allowed to move separately to locations which were determined by using a nonlinear optimization procedure based on the measured sound field data. To test this approach, experiments were conducted using a small loudspeaker cabinet; measurements were made using an array of microphones on all sides of the loudspeaker. Read More

Trauma Surg Acute Care Open 2018 26;3(1):e000251. Epub 2018 Nov 26.

Division of Acute Care Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Background: Missed injury of the diaphragm may result in hernia formation, enteric strangulation, and death. Compounding the problem, diaphragmatic injuries are rare and difficult to diagnose with standard imaging. As such, for patients with high suspicion of injury, operative exploration remains the gold standard for diagnosis. Read More

Respir Care 2018 Dec 11. Epub 2018 Dec 11.

Pediatric Intensive Care Unit, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Montreal, Québec, Canada.

Background: The present study aimed to characterize the behavior of 3 components of respiratory muscle function during mechanical ventilation weaning in children to better understand the respective impact of a spontaneous breathing trial on ventilatory mechanical action (esophageal pressure [P], ventilatory demand (electrical activity of the diaphragm [EA]), and oxygen consumption.

Methods: This was a prospective single-center study. All children ≥ 1 months and <18 y old who were intubated and on mechanical ventilation, and who were hospitalized in the pediatric ICU were eligible. Read More

J Cardiol Cases 2013 Mar 1;7(3):e71-e73. Epub 2013 Feb 1.

Division of Cardiology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, 80, Guro-2-dong, Guro-gu, Seoul 152 703, Korea.

Oculopharyngeal muscular dystrophy (OPMD) is an uncommon autosomal dominant disorder that has been characterized by slow progression. Neuromuscular disease is one of several etiologies of pulmonary volume restriction from extrinsic or parenchymatous causes and can lead to pulmonary hypertension and right-sided heart failure, which is consistent with cor pulmonale. Here we describe a case of an OPMD patient with cor pulmonale that was reversed using mechanically-assisted ventilation. Read More

Trauma Case Rep 2018 Dec 28;18:52-55. Epub 2018 Nov 28.

Division of Trauma Surgery, Department of Surgery, Ajou University School of Medicine, Republic of Korea.

A combined laparotomy and thoracotomy is required in a few trauma patients. The anterior approach is a standard procedure used in such cases; however, a different approach may be required. Recently, we managed a patient who presented with a crush injury to the left side of his chest with associated bowel herniation. Read More

World J Hepatol 2018 Nov;10(11):887-891

Scripps Center for Organ Transplant, Scripps Green Hospital, La Jolla, CA 92037, United States.

Abdominal pain with elevated transaminases from inferior vena cava (IVC) obstruction is a relatively common reason for referral and further workup by a hepatologist. The differential for the cause of IVC obstruction is extensive, and the most common etiologies include clotting disorders or recent trauma. In some situations the common etiologies have been ruled out, and the underlying process for the patient's symptoms is still not explained. Read More

Appl Clin Genet 2018 15;11:135-144. Epub 2018 Nov 15.

Division of Pediatric Pulmonology and Sleep Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA,

Congenital central hypoventilation syndrome (CCHS) is a rare genetic disorder of the autonomic nervous system (ANS) and respiratory control. This disorder, formerly referred to as Ondine's curse, is due to a mutation in the gene that affects the development of the neural crest cells. CCHS has an autosomal dominant pattern of inheritance. Read More

PLoS Genet 2018 Dec 10;14(12):e1007822. Epub 2018 Dec 10.

Department of Systems Biology, Columbia University Medical Center, New York, New York, United States of America.

Congenital diaphragmatic hernia (CDH) is a severe birth defect that is often accompanied by other congenital anomalies. Previous exome sequencing studies for CDH have supported a role of de novo damaging variants but did not identify any recurrently mutated genes. To investigate further the genetics of CDH, we analyzed de novo coding variants in 362 proband-parent trios including 271 new trios reported in this study. Read More

Curr Opin Crit Care 2018 Dec 5. Epub 2018 Dec 5.

Interdepartmental Division of Critical Care Medicine, University of Toronto.

Purpose Of Review: Diaphragm dysfunction is common in mechanically ventilated patients and predisposes them to prolonged ventilator dependence and poor clinical outcomes. Mechanical ventilation is a major cause of diaphragm dysfunction in these patients, raising the possibility that diaphragm dysfunction might be prevented if mechanical ventilation can be optimized to avoid diaphragm injury - a concept referred to as diaphragm-protective ventilation. This review surveys the evidence supporting the concept of diaphragm-protective ventilation and introduces potential routes and challenges to pursuing this strategy. Read More

IEEE J Biomed Health Inform 2018 Dec 5. Epub 2018 Dec 5.

The use of wearable devices in clinical routines could reduce healthcare costs and improve the quality of assessment in patients with chronic respiratory diseases. The purpose of this study is to evaluate the capacity of a Shimmer3 wearable device to extract reliable cardiorespiratory parameters from surface diaphragm electromyography (EMGdi). Twenty healthy volunteers underwent an incremental load respiratory test whilst EMGdi was recorded with a Shimmer3 wearable device (EMGdiW). Read More

Nanomedicine 2018 Dec 7. Epub 2018 Dec 7.

Pediatric Neuromuscular Laboratory, Hadassah Hebrew University Medical Center, Jerusalem, Israel; Felsenstein Medical Research Center (FMRC), Schneider Children's Medical Center, Tel-Aviv University, Israel. Electronic address:

Glucocorticosteroids are the most efficacious anti-inflammatory agents and the gold standard treatment in Duchenne muscular dystrophy (DMD). However, their chronic use may lead to severe side effects. We evaluated the use of a novel injectable steroidal nano-drug in mdx mouse model of DMD by comparing the efficacy of nano-liposomes remotely loaded with the steroid prodrug, methylprednisolone hemisuccinate (MPS) with the same steroid as-is, in short (4-weeks) and long-term (58-weeks) treatments. Read More

J Minim Invasive Gynecol 2018 Dec 7. Epub 2018 Dec 7.

Department of Surgical Gynecology, Mayo Clinic Hospital, Phoenix, Arizona.

Study Objective: To estimate pulmonary complications and diaphragm recurrence after resection of diaphragm metastases by minimally invasive surgery (MIS) for epithelial ovarian cancer (EOC).

Design: Retrospective analysis.

Design Classification: III. Read More

Neurobiol Dis 2018 Dec 4. Epub 2018 Dec 4.

Departments of Neuroscience, Genentech, South San Francisco, CA, USA. Electronic address:

Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease affecting motor neurons, is characterized by rapid decline of motor function and ultimately respiratory failure. As motor neuron death occurs late in the disease, therapeutics that prevent the initial disassembly of the neuromuscular junction may offer optimal functional benefit and delay disease progression. To test this hypothesis, we treated the SOD1 mouse model of ALS with an agonist antibody to muscle specific kinase (MuSK), a receptor tyrosine kinase required for the formation and maintenance of the neuromuscular junction. Read More

Can J Cardiol 2018 Dec 19;34(12):1688.e21-1688.e23. Epub 2018 Oct 19.

Northern Ontario School of Medicine, Health Sciences North, Sudbury, Ontario, Canada. Electronic address:

Diaphragmatic eventration in old age is a rare phenomenon. Typically, it is thought to originate as a result of failure of development of the muscles of the diaphragm. Less commonly, it can occur secondary to acquired conditions resulting from spinal cord or phrenic nerve injury and is only detected incidentally when the patient presents with dyspnea, chest infection, or cardiac compression symptoms. Read More

Respirol Case Rep 2019 Feb 28;7(2):e00391. Epub 2018 Nov 28.

Department of Medical Oncology Izumi City General Hospital Izumi Japan.

Porous diaphragm syndrome describes a defect in the diaphragm in which substances pass from the peritoneal cavity to the pleural space. Defects may be congenital or acquired. Acquired defects are caused by the thinning and eventual splitting of collagen fibres in the tendinous part of the diaphragm. Read More

Soft Robot 2018 Dec 1. Epub 2018 Dec 1.

1 Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering , ETH Zurich, Zurich, Switzerland .

We present a long-term performance study on a pneumatically actuated soft pump (SP). The pump was manufactured by adapting rubber compression technology. Important parameters influencing pump performance (e. Read More

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Otolaryngology Section, Head and Neck Surgery, Hospital Universitari Germans Trias i Pujol.

Introduction: Minimally invasive transoral surgery for oropharyngeal cancer is a challenge for head and neck surgeons because of the inside-out anatomic presentation and the confined workspace. This study was performed to describe the main neurovascular and muscular landmarks in a transoral approach. The authors propose an anatomic stratification for this surgery. Read More

Am J Physiol Heart Circ Physiol 2018 Dec 28;315(6):H1691-H1702. Epub 2018 Sep 28.

Lund University, Department of Clinical Sciences, Lund, Clinical Physiology, Skåne University Hospital , Sweden.

Intracardiac hemodynamic forces have been proposed to influence remodeling and be a marker of ventricular dysfunction. We aimed to quantify the hemodynamic forces in patients with repaired tetralogy of Fallot (rToF) to further understand the pathophysiological mechanisms as this could be a potential marker for pulmonary valve replacement (PVR) in these patients. Patients with rToF and pulmonary regurgitation (PR) > 20% ( n = 18) and healthy control subjects ( n = 15) underwent MRI, including four-dimensional flow. Read More

Contraception 2018 Nov 29. Epub 2018 Nov 29.

The Ohio State University (OSU), College of Public Health (CPH), Division of Epidemiology, Cunz Hall, 1841 Neil Avenue, Columbus, OH, 43210, USA. Electronic address:

Objectives: To calculate the prevalence and identify correlates of unmet need for contraception and to assess whether prevalence of use of effective contraception and long-acting reversible contraception (LARC) has changed over time among married or cohabiting, reproductive-age women in Vietnam.

Methods: Study population was drawn from nationally-representative Multiple Indicator Cluster Surveys conducted in 2000, 2006, 2011, and 2014. Unmet need for contraception was defined as occurring when a fecund, married or cohabiting woman is not using any method of contraception but either does not want children or wants to delay birth for at least one year or until marriage. Read More

J Pediatr Surg 2018 Nov 7. Epub 2018 Nov 7.

Center for Colorectal and Pelvic Reconstruction, Nationwide Children's Hospital, Columbus, OH.

Aim Of The Study: The goals of urinary reconstruction in urogenital sinus and cloacal repair include: (1) positioning of the bladder neck above the urogenital diaphragm to maximize future urinary continence, and (2) creating a visible urethra that can be catheterized if needed. A recent algorithm in cloacal reconstruction proposed a urethral length of 1.5 cm as the key determinant in deciding whether to perform a total urogenital mobilization or a urogenital separation, the hypothesis being that a 1. Read More

J Cardiovasc Electrophysiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiology, Hippokration General Hospital, 114 Vasilisis Sofias str, Athens, Greece.

Introduction: Cardiac perforation of the right ventricle associated with pacemaker or implantable cardioverter-defibrillator (ICD) leads' implantation is an uncommon, albeit potentially life-threatening, complication. The aim of this study is to further identify the optimal therapeutic strategy especially when lead dislocation has occurred outside the pericardial sac.

Methods And Results: The study population included 10 consecutive patients (6 female, mean age: 66. Read More

Chin Med J (Engl) 2018 Dec;131(23):2800-2807

Chronic Airway Disease Research Office, Department of Respiratory, Geriatric Hospital of Nanjing Medical University, Jiangsu Province Geriatric Hospital, Nanjing, Jiangsu 210024, China.

Background: Neural respiratory drive (NRD) using diaphragm electromyography through an invasive transesophageal multi-electrode catheter can be used as a feasible clinical physiological parameter in patients with chronic obstructive pulmonary disease (COPD) to provide useful information on the treatment response. However, it remains unknown whether the surface diaphragm electromyogram (EMGdi) could be used to identify the deterioration of clinical symptoms and to predict the necessity of hospitalization in acute exacerbation of COPD (AECOPD) patients.

Methods: COPD patients visiting the outpatient department due to acute exacerbation were enrolled in this study. Read More

Zhejiang Da Xue Xue Bao Yi Xue Ban 2018 Feb;47(4):329-337

Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Department of Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.

Objective: To observe and verify the key anatomies of DeLancey's three levels of vaginal support theory through laparoscopic surgery by space dissection technique.

Methods: The features and stress performance of related anatomies were observed and analyzed in laparoscopic type C hysterectomy and pelvic lymphadenectomy for cervical cancer by natural space exposures.

Results: The main ligament-like structure at level Ⅰ was the uterosacral ligament, which acted as the main apical fixation in the sacral direction, while the cardinal ligament was mainly composed of vascular system, lymph-vessels and loose connective tissue around them, lacking the tough connective tissue structures, which was connected to the internal iliac vascular system. Read More

Surg Endosc 2018 Dec 3. Epub 2018 Dec 3.

Division of Thoracic Surgery, Department of Surgery, MedStar Georgetown University Hospital, 3800 Reservoir Rd, NW, Washington, DC, 20007, USA.

Introduction: Double lumen tube (DLT) intubation is used for lung isolation but is not without disadvantages including increased intubation time, anesthesia expertise, risk of airway trauma, and costs over single lumen tube (SLT) intubation. SLT intubation with CO insufflation can be used as an alternative for lung isolation. We reviewed our experience with this technique during thoracoscopic surgery. Read More

Can Respir J 2018 30;2018:9761583. Epub 2018 Oct 30.

Faculty of Medicine, University of Belgrade, Serbia.

Aim: The aim of this study was to evaluate the role of thoracic sonography in treatment of pleural effusions and to identify sonographic indicators for surgical intervention.

Materials And Methods: This study included 378 patients with pleural effusions. US characteristics of effusions as the echo structure and pleural thickening were analyzed. Read More

Pulmonology 2018 Nov 30. Epub 2018 Nov 30.

Pneumology Service, University Hospital Complex of Santiago, Santiago de Compostela, Spain; Interdisciplinary Research Group in Pulmonology, Institute of Sanitary Research of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.

The diaphragm is the main breathing muscle and contraction of the diaphragm is vital for ventilation so any disease that interferes with diaphragmatic innervation, contractile muscle function, or mechanical coupling to the chest wall can cause diaphragm dysfunction. Diaphragm dysfunction is associated with dyspnoea, intolerance to exercise, sleep disturbances, hypersomnia, with a potential impact on survival. Diagnosis of diaphragm dysfunction is based on static and dynamic imaging tests (especially ultrasound) and pulmonary function and phrenic nerve stimulation tests. Read More

Surg Radiol Anat 2018 Nov 29. Epub 2018 Nov 29.

Department of Surgery, Teikyo University Chiba Medical Center, 3246-3, Anesaki, Ichihara, Chiba, 299-0111, Japan.

Purpose: Left trisectionectomy (LT) extending to the segment I with bile duct resection for perihilar cholangiocarcinoma (PHC) is a technically demanding procedure with high morbidity. Liver transection during LT is generally conducted to expose the right hepatic vein (RHV) on the remnant side. In clinical practice, we have often encountered a discrepancy between the theoretical RHV-oriented plane and the actual right intersectional plane. Read More

Int J Radiat Oncol Biol Phys 2018 Nov 26. Epub 2018 Nov 26.

Department of Radiotherapy Physics, Northern Centre for Cancer Care, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Purpose: Reducing respiratory motion during the delivery of radiotherapy reduces the volume of healthy tissues irradiated and may decrease radiation induced toxicity. The purpose of this study was to assess the potential for rapid shallow non-invasive mechanical ventilation to reduce internal anatomy motion for radiotherapy purposes.

Material And Methods: Ten healthy volunteers (age 22-54years; mean 38years; 6 female and 4 male) were scanned on an MR scanner during normal breathing and at 2 ventilator induced frequencies; 20 and 25 breaths per minute for 3 minutes. Read More

Int J Hyperthermia 2018 Nov 29:1-8. Epub 2018 Nov 29.

a Department of Medical Ultrasonics , The Sixth Affiliated Hospital of Sun Yat-Sen University , Guangzhou , China.

Purpose: To investigate the clinical effectiveness and safety of ultrasound (US)-guided percutaneous microwave ablation (MWA) for colorectal liver metastasis (CRLM) and evaluate the influencing factors of local efficacy.

Methods: From January 2013 to January 2017, 137 CRLM patients accepting US-guided percutaneous MWA were included. The 2450-MHz microwave ablation system and a cooled-shaft antenna were used. Read More

Front Physiol 2018 14;9:1618. Epub 2018 Nov 14.

Clinical Exercise & Respiratory Physiology Laboratory, Department of Kinesiology and Physical Education, McGill University, Montreal, QC, Canada.

We tested the hypothesis that abdominal binding (AB) would reduce breathlessness and improve exercise tolerance by enhancing neuromuscular efficiency of the diaphragm during exercise in adults with chronic obstructive pulmonary disease (COPD). In a randomized, controlled, crossover trial, 20 adults with COPD (mean ± SD FEV, 60 ± 16% predicted) completed a symptom-limited constant-load cycle endurance exercise test at 75% of their peak incremental power output with concomitant measures of the diaphragm electromyogram (EMGdi) and respiratory pressures without (CTRL) vs. with AB sufficient to increase end-expiratory gastric pressure (Pga,ee) by 6. Read More

Insights Imaging 2018 Dec 27;9(6):989-1005. Epub 2018 Nov 27.

Imaging Science, University of Rochester Medical Center, 601, Elmwood Avenue, Rochester, NY, 14642, USA.

Thoracic hernias are characterised by either protrusion of the thoracic contents outside their normal anatomical confines or extension of the abdominal contents within the thorax. Thoracic hernias can be either congenital or acquired in aetiology. They can occur at the level of the thoracic inlet, chest wall or diaphragm. Read More

Iran J Parasitol 2018 Jul-Sep;13(3):430-439

Dept. of Medical Parasitology & Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Toxoplasmosis is a global zoonotic disease that causes critical medical complications in neonates and immunocompromised persons. Infection rates in cats, specifically stray cats, are believed to be the best sentry of the level of in the environment. Therefore, in this study, we surveyed infection in stray cats of Shiraz, one of the metropolises of Iran. Read More

Iran J Parasitol 2018 Jul-Sep;13(3):382-391

Dept. of Medical Parasitology and Mycology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Background: We isolated from camels by bioassay method in mice model and detect parasitic DNA in brain mice by molecular methods.

Methods: One hundred tissue samples including heart (n=50), and diaphragm (n=50) were collected from camels (n=50) slaughtered in abattoirs from Feb to Oct 2015 in three provinces located in eastern Iran. In first, blood sample from 50 camels was assayed for anti- antibodies by modified agglutination test (MAT) test. Read More

Nat Commun 2018 11 27;9(1):4843. Epub 2018 Nov 27.

Department of Neurosciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.

There exists an abundance of barriers that hinder functional recovery following spinal cord injury, especially at chronic stages. Here, we examine the rescue of breathing up to 1.5 years following cervical hemisection in the rat. Read More

Proc Natl Acad Sci U S A 2018 Dec 27;115(50):12751-12756. Epub 2018 Nov 27.

Laboratory for Nanoscale Cell Biology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.

Release of neurotransmitters from synaptic vesicles begins with a narrow fusion pore, the structure of which remains unresolved. To obtain a structural model of the fusion pore, we performed coarse-grained molecular dynamics simulations of fusion between a nanodisc and a planar bilayer bridged by four partially unzipped SNARE complexes. The simulations revealed that zipping of SNARE complexes pulls the polar C-terminal residues of the synaptobrevin 2 and syntaxin 1A transmembrane domains to form a hydrophilic core between the two distal leaflets, inducing fusion pore formation. Read More

SAGE Open Med Case Rep 2018 19;6:2050313X18812213. Epub 2018 Nov 19.

Hospital Segamat, Segamat, Malaysia.

The differentiation between a pseudo-pneumoperitoneum and true pneumoperitoneum on an initial chest radiograph is challenging but essential to clinical practice. The former is managed conservatively whereas the latter may require surgical intervention. Chilaiditi's sign describes a rare incidental radiological finding of gas filled bowel interpositioned between the right hemi-diaphragm and the liver, which is visible on a plain abdominal or chest radiograph. Read More

Ophthalmologe 2018 Nov 26. Epub 2018 Nov 26.

Zentrum für Augenheilkunde, Universität zu Köln, Kerpenerstr. 62, 50924, Köln, Deutschland.

Background: Descemet membrane endothelial keratoplasty (DMEK) has become the standard surgical treatment for Fuchs' endothelial corneal dystrophy (FECD) in Germany. In addition to classical FECD, there are endothelial disorders amenable to DMEK associated with complex changes in the anterior segment of the eye, such as anterior synechia of the iris, larger iris defects, after glaucoma surgery, after vitrectomy and after trauma.

Objective: This article provides an overview of the possibilities to treat patients with complex anterior segment situations in the presence of corneal endothelial decompensation with DMEK. Read More

BMC Public Health 2018 Nov 26;18(1):1294. Epub 2018 Nov 26.

African Community Center for Social Sustainability (ACCESS), Nakaseke, Uganda.

Background: Unmet need for family planning exceeds 33% in Uganda. One approach to decreasing unmet need is promoting male involvement in family planning. Male disapproval of use of family planning by their female partners and misconceptions about side effects are barriers to family planning globally and in Uganda in particular. Read More

J Am Osteopath Assoc 2018 Dec;118(12):798-805

Context: In 2012, the US wound registry estimated that the cost of managing chronic wounds in the United States exceeded $50 billion. A large percentage of these wounds are venous stasis ulcers of the lower extremity. Evidence suggests that adjuvant osteopathic manipulative treatment (OMT) may provide a benefit by reducing edema and subsequent healing times in venous stasis ulcers of the lower extremity. Read More

J Vet Med Sci 2018 Nov 23. Epub 2018 Nov 23.

Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University.

Wild boars are a reservoir for many zoonotic pathogens and a good sentinel for surveillance of zoonotic viral infections, but collection of serum samples from wild boars in the field is sometimes difficult and requires special equipment and techniques. In this study, ELISA using meat juices extracted from the heart and diaphragm of wild boars, instead of serum samples, was performed to detect antibodies against zoonotic pathogens, Japanese encephalitis virus and hepatitis E virus. The results of ELISA using meat juice samples were significantly correlated with those using serum samples and meat juice contained one-fifth the antibodies of serum samples. Read More