174,641 results match your criteria Dialysis & Transplantation[Journal]


Individualized Hemodialysis Treatment: A Perspective on Residual Kidney Function and Precision Medicine in Nephrology.

Cardiorenal Med 2018 Dec 11;9(2):69-82. Epub 2018 Dec 11.

Harold Simmons Center of Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine School of Medicine, Orange, California,

Background: Residual kidney function (RKF) is often expected to inevitably and rapidly decline among hemodialysis patients and, hence, has been inadvertently ignored in clinical practice. The importance of RKF has been revisited in some recent studies. Given that patients with end-stage renal disease now tend to initiate maintenance hemodialysis therapy with higher RKF levels, there seem to be important opportunities for incremental hemo-dialysis by individualizing the dose and frequency according to their RKF levels. Read More

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December 2018

The association of klotho gene polymorphism and the regulation of calcium-phosphate metabolism disorders in patients with ESRD.

Nephrology (Carlton) 2018 Dec 8. Epub 2018 Dec 8.

Nephrology Department of Subei People's Hospital, Yangzhou, 225009, Jiangsu, China.

Background: Klotho G-395-A gene polymorphism is associated with several diseases; however, its association with calcium-phosphate metabolism disorders in end-stage renal disease (ESRD) is unknown.

Methods: 137 patients with ESRD and 80 healthy adults (control) were enrolled in the study. Patients with ESRD were divided into three subgroups: hemodialysis (A1, n=52), peritoneal dialysis (A2, n=30), and non-dialysis (A3, n=55). Read More

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December 2018

The epidemiology of HCV infection in patients with advanced CKD/ESRD: A global perspective.

Semin Dial 2018 Dec 9. Epub 2018 Dec 9.

Division of Nephrology, Maggiore Hospital and IRCCS Foundation, Milan, Italy.

Liver disease in patients with chronic kidney disease (CKD) is most commonly due to hepatitis C virus (HCV) and contributes to increased rates of mortality. Among the pre-dialysis population, the estimated prevalence of anti-HCV positivity is based on few, limited-size studies. In hemodialysis patients however, HCV remains very prevalent despite large declines in seropositivity rates in dialysis facilities in developed countries after preventive measures were adopted in the 1990s. Read More

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December 2018
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Influence of colonic dialysis using Gubenxiezhuo on the distribution of gut microflora in uremia rats.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Nephrology, Minhang Hospital,Fudan University, Shanghai, China.

Objective: This study aimed to explore the underlying function of Gubenxiezhuo dialysis on the distribution of gut microflora uremia.

Methods: A uremia rat model was constructed, and the morphology of renal tissue was determined using the hematoxylin-eosin (H&E) staining. Moreover, the blood samples were collected and the expression of IL-1β, IL-6, and CRP was determined using enzyme-linked immunosorbent assay. Read More

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December 2018

A survey demonstrates limited palliative care structures in paediatric nephrology from the perspective of a multidisciplinary healthcare team.

Acta Paediatr 2018 Dec 11. Epub 2018 Dec 11.

Department of Paediatric Gastroenterology, Nephrology and Metabolic Diseases, Charité - Universitätsmedizin Berlin, Germany.

Aim: Children and adolescents with end stage renal disease face a high morbidity and mortality. Palliative care provides a multidisciplinary approach to reduce disease burden and improve quality of life. This study evaluated concepts and current structures of palliative care from the perspective of a multidisciplinary paediatric nephrology team including physicians, nurses and psychosocial health professionals. Read More

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December 2018

Thrombotic thrombocytopenic purpura: A 5-year tertiary care centre experience.

J Clin Apher 2018 Dec 8. Epub 2018 Dec 8.

Department of Molecular Medicine and Haematology, Faculty of Health Sciences, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa.

Introduction: Thrombotic thrombocytopenic purpura (TTP) is associated with high mortality if not managed timeously with therapeutic plasma exchange (TPE). TTP secondary to human immunodeficiency virus (HIV) infection is unique to sub-Saharan Africa. The management and outcome of TTP in the era of improved access to therapy has not been described. Read More

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December 2018

Correction to: An open-label, single-dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of cinacalcet in pediatric subjects aged 28 days to < 6 years with chronic kidney disease receiving dialysis.

Pediatr Nephrol 2018 Dec 7. Epub 2018 Dec 7.

Children's Mercy Hospital, Kansas City, MO, USA.

The original version of this article unfortunately contained three mistakes. In Table 1, the last line under "Key Inclusion Criteria" should read "Normal or clinically acceptable ECGs at screening and at day - 1." In addition, the abbreviation "IP" in the legend to Table 1 stands for "investigational product. Read More

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December 2018

Steroids in cardiac surgery trial: a substudy of surgical site infections.

Can J Anaesth 2018 Dec 10. Epub 2018 Dec 10.

Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.

Purpose: Postoperative infection, particularly in cardiac surgery, results in significant morbidity, mortality, and healthcare cost. Identification of novel predictors of postoperative infection can target high-risk populations for prophylactic intervention.

Methods: Steroids in cardiac surgery (SIRS) was a multi-centre randomized-controlled trial assessing intraoperative administration of methylprednisone during cardiac surgery, which enrolled 7,507 patients across 80 centres in 18 countries. Read More

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December 2018

Aortic pulse wave velocity is greater in peritoneal dialysis patients with lower dual energy X-ray absorptiometry (DXA) femoral neck bone mineral density.

J Nephrol 2018 Dec 10. Epub 2018 Dec 10.

UCL Department of Nephrology, Royal Free hospital, University College London, Rowland Hill Street, London, NW3 2PF, UK.

Background: Increased vascular stiffness is associated with low bone mineral density (BMD) in the general population, and both are risk factors for mortality. We wished to determine whether vascular stiffness is associated with BMD in peritoneal dialysis (PD) patients.

Methods: We measured vascular stiffness by aortic pulse wave velocity (aPWV), BMD by dual electron absorptiometry (DXA) scanning, and body composition using bioimpedance. Read More

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December 2018

The Importance of Chronic Magnesium Deficiency in human disease and the Gitelman's syndrome paradox.

QJM 2018 Dec 6. Epub 2018 Dec 6.

Department of Medicine, Nephrology, Dialysis and Transplantation Unit, University of Padova, Italy.

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December 2018

Effect of Oral Alfacalcidol on Clinical Outcomes in Patients Without Secondary Hyperparathyroidism Receiving Maintenance Hemodialysis: The J-DAVID Randomized Clinical Trial.

JAMA 2018 Dec;320(22):2325-2334

Hemodialysis Center, Inoue Hospital, Soryu Medical Corporation, Osaka, Japan.

Importance: Patients with chronic kidney disease have impaired vitamin D activation and elevated cardiovascular risk. Observational studies in patients treated with hemodialysis showed that the use of active vitamin D sterols was associated with lower risk of all-cause mortality, regardless of parathyroid hormone levels.

Objective: To determine whether vitamin D receptor activators reduce cardiovascular events and mortality in patients without secondary hyperparathyroidism undergoing hemodialysis. Read More

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December 2018

[Clinical and microbiological aspects of peritonitis associated with peritoneal dialysis in adult patients with chronic renal failure in the Emergency Department].

Rev Chilena Infectol 2018 ;35(3):225-232

Escuela Superior de Medicina, Instituto Politécnico Nacional, Instituto Mexicano del Seguro Social, México, D.F, México.

Background: Peritonitis is the most important and frequent complication of peritoneal dialysis (PD). Bacterial infections are responsible in most cases, with characteristic symptoms.

Aim: To determine the most frequent pathogens in peritonitis associated with PD in patients with chronic renal failure (CRF). Read More

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January 2018

Chronic kidney disease patients who smoke have higher serum phosphorus.

J Bras Nefrol 2018 Dec 10. Epub 2018 Dec 10.

Universidade Nove de Julho, São Paulo, SP, Brasil.

Introduction: Mineral and bone metabolism disorders in chronic kidney disease (CKD-MBD) constitute a syndrome defined by changes in calcium, phosphorus (P), vitamin D and parathormone, fibroblast growth factor 23 (FGF-23) and its specific cofactor, Klotho. CKD-MBD, as well as smoking, are associated with an increased risk of cardiovascular disease. However, it is not known whether or not smoking impacts the cardiovascular risk in CKD- MBD. Read More

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December 2018

Bipolar en bloc tumor resection versus standard monopolar TURBT - which is the best way to go in non-invasive bladder cancer?

Rom J Morphol Embryol 2018 ;59(3):773-780

Department of Nephrology and Dialysis, "St. John" Emergency Clinical Hospital, Clinical Department No. 3, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

The aim of the study was to observe similarities and differences regarding surgical safety and prognosis between en bloc bipolar resection and monopolar transurethral resection of bladder tumors (TURBTs) in medium size papillary non-muscle invasive bladder tumors (NMIBTs). A total of 90 patients with papillary bladder tumors presenting a diameter between 1 and 3 cm were equally divided and alternatively assigned for en bloc bipolar ablation (the study group) and conventional TURBT (the control group). During one year, every three months, the follow-up was performed and the protocol included urinary cytology and cystoscopy. Read More

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January 2018

Plumbagin-Loaded Nanoemulsion Drug Delivery Formulation and Evaluation of Antiproliferative Effect on Prostate Cancer Cells.

Biomed Res Int 2018 11;2018:9035452. Epub 2018 Nov 11.

Vaccine Research Institute of San Diego (VRISD), San Diego Science Center, San Diego, California, USA.

Background: Plumbagin, a medicinal plant-derived 5-hydroxy-2-methyl-1,4-naphthoquinone, is an emerging drug with a variety of pharmacological effects, including potent anticancer activity. We have previously shown that plumbagin improves the efficacy of androgen deprivation therapy (ADT) in prostate cancer and it is now being evaluated in phase I clinical trial. However, the development of formulation of plumbagin as a compound with sparing solubility in water is challenging. Read More

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November 2018

Chronic kidney disease in the emergency centre: A prospective observational study.

Afr J Emerg Med 2018 Dec 27;8(4):134-139. Epub 2018 Jul 27.

Department of Medicine, Federal Medical Center, Owo, Nigeria.

Introduction: Late presentation, usually to the emergency centre (EC), is frequently reported among patients with chronic kidney disease (CKD) in resource-limited settings, and is known to be associated with poor outcomes. This study aims to describe the pattern of EC presentation of adults with CKD in Southwest Nigeria.

Methods: This was a prospective observational study of 158 consecutively presenting CKD patients at the EC of two tertiary hospitals in Southwest Nigeria. Read More

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December 2018

IL-17 in Peritoneal Dialysis-Associated Inflammation and Angiogenesis: Conclusions and Perspectives.

Front Physiol 2018 26;9:1694. Epub 2018 Nov 26.

Department of Medicine I, Nephrology, Transplantation, Medical Intensive Care, University of Witten/Herdecke, Cologne-Merheim Medical Center, Cologne, Germany.

Long-term peritoneal dialysis (PD) is associated with peritoneal membrane remodeling. This includes changes in peritoneal vasculature, which may ultimately lead to inadequate solute and water removal and treatment failure. The potential cause of such alterations is chronic inflammation induced by repeated episodes of infectious peritonitis and/or exposure to bioincompatible PD fluids. Read More

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November 2018

The Rate of Venous Thromboembolism Before and After Spine Surgery as Determined with Indirect Multidetector CT.

JB JS Open Access 2018 Sep 15;3(3):e0015. Epub 2018 Aug 15.

Department of Orthopaedic Surgery, Jichi Medical University, Shimotsuke, Japan.

Background: This prospective cohort study investigated the rate of venous thromboembolism (VTE) before and after spine surgery as determined with use of indirect multidetector computed tomography (MDCT).

Methods: We performed a prospective study of 105 patients (36 women and 69 men ranging in age from 38 to 88 years) undergoing spine surgery at 2 institutions. Indirect MDCT was performed before and 3 days after surgery. Read More

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September 2018

TPP2 mutation associated with sterile brain inflammation mimicking MS.

Neurol Genet 2018 Dec 13;4(6):e285. Epub 2018 Nov 13.

Department of Neurology (E.M.R., S.P., C.S., F.L., F.Z., A.Z.), Medical University of Vienna, Austria; Institut für Humangenetik (E.G., T.W., T.S.), Helmholtz Zentrum München, Germany; Center for Brain Research (T.Z., H.L.), Medical University of Vienna; Division of Nephrology and Dialysis (C.K.), Department of Internal Medicine III, Medical University of Vienna; Department of Physical Medicine (M.K.), Rehabilitation and Occupational Medicine, Medical University of Vienna, Austria; Lübeck Interdisciplinary Platform for Genome Analytics (C.M.L.), Institutes of Neurogenetics and for Cardiogenetics, University of Lübeck; Department of Neurology and Neuroimaging Center (NIC) (C.M.L.), Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz; Department of Human Genetics (S.H., J.T.E.), Ruhr-University Bochum; Herdecke (J.T.E.), ZBAF, Faculty of Health, University Witten; Department of Neurology (U.K.Z., M.H.), Neuroimmunological Section, University of Rostock; Department of Neurology (A.D.), Department of Clinical Genomics (A.D.), Department of Neuroscience (A.D.), Jeweils Mayo Clinic, Jacksonville, FL; Department of Neurology (S.G.M.), University of Muenster, Germany; Department of Physiology and Biochemistry (M.A., B.M.), School of Medicine, the University of Jordan; The National Center (Institute) for Diabetes (M.E.-K.), Endocrinology and Genetics (NCDEG), Amman, Jordan; Department of Medical Genetics (C.V.-G., A.D.S.), University of British Columbia, Vancouver, Canada; Department of Medical Biochemistry and Microbiology (B.T.), Uppsala University, Sweden; Karl Landsteiner Institute for Neuroimmunological and Neurodegenerative Disorders (W.K.), SMZ-Ost-Donauspital, Vienna, Austria; and Institute for Neuroimmunological and Neurodegenerative Disorders (W.K.), SMZ-Ost-Donauspital, Vienna, Austria.

Objective: To ascertain the genetic cause of a consanguineous family from Syria suffering from a sterile brain inflammation mimicking a mild nonprogressive form of MS.

Methods: We used homozygosity mapping and next-generation sequencing to detect the disease-causing gene in the affected siblings. In addition, we performed RNA and protein expression studies, enzymatic activity assays, immunohistochemistry, and targeted sequencing of further MS cases from Austria, Germany, Canada and Jordan. Read More

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December 2018
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Data on the assessment of LV mechanics by speckle tracking echocardiography in ADPKD patients.

Data Brief 2018 Dec 14;21:2075-2081. Epub 2018 Nov 14.

IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Clinical Research Centre for Rare Diseases "Aldo e Cele Daccò", Bergamo, Italy.

In this article, we report anthropometric, clinical and laboratory data from Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients with mild to moderate renal dysfunction and normal LV ejection fraction and from age- and sex-matched healthy controls and renal controls. Factors influencing LV untwisting rate in the group of ADPKD patients are also reported. For further interpretation and discussion please refer to the research article "Left ventricular dysfunction in ADPKD and effects of Octreotide-LAR: a cross-sectional and longitudinal sub study of the ALADIN trial" (Spinelli et al. Read More

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December 2018

You Can Do That? Performing Total Recanalization of Completely Stented Arterial-venous Grafts.

Cureus 2018 Oct 1;10(10):e3396. Epub 2018 Oct 1.

Interventional Radiology, University of Florida College of Medicine, Jacksonville, USA.

Establishing venous access in chronic dialysis patients is conducted by the insertion of polytetrafluoroethylene arterial-venous (AV) grafts. The continual access of these grafts allows for potential failure over extended periods of hemodialysis treatment, as a result of thrombosis and pseudoaneurysm formation. Patency of AV grafts requires interventional management of thrombosis and pseudoaneurysm formation, including thrombectomy and covered stent placement, respectively. Read More

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October 2018

Suggested Procedures for the Reproducible Synthesis of Poly(d,l-lactide-co-glycolide) Nanoparticles Using the Emulsification Solvent Diffusion Platform.

Curr Nanosci 2018 Oct;14(5):448-453

1Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Pde, ParkvilleVIC, 3052, Australia; 2ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Melbourne, VIC, 3052, Australia; 3School of Biomedical Sciences, University of Queensland, St LuciaQLD, 4072, Australia.

Background: Poly(d,l-lactide-co-glycolide) (PLGA) based biodegradable nanoparticles are of key interest for the development of controlled release drug delivery systems and for other biomedical applications. It has been reported that PLGA polymers can be converted into colloidal nanoparticulate systems by various techniques, such as emulsification-diffusion, emulsification-evaporation, interfacial deposition, salting out, dialysis and nanoprecipitation. Emulsification-evaporation with water immisci-ble solvents including dichloromethane and chloroform has been the preferred method for the synthesis of PLGA nanoparticles due to the low boiling point and limited water solubility of these solvents. Read More

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October 2018

Evaluation of a protocol for coronary artery disease investigation in asymptomatic elderly hemodialysis patients.

Int J Nephrol Renovasc Dis 2018 14;11:303-311. Epub 2018 Nov 14.

Heart Institute (InCor) and Renal Transplant Unit, Division of Urology, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, SP, Brazil,

Background: Coronary artery disease (CAD) is prevalent in older patients on dialysis, but the prognostic relevance of coronary assessment in asymptomatic subjects remains undefined. We tested the usefulness of a protocol, based on clinical, invasive, and noninvasive coronary assessment, by answering these questions: Could selecting asymptomatic patients for coronary invasive assessment identify those at higher risk of events? Is CAD associated with a worse prognosis?

Methods: A retrospective study including 276 asymptomatic patients at least 65 years old on the waiting list, prospectively evaluated for CAD and followed up until death or renal transplantation, were classified into two groups: 1) low-risk patients who did not undergo coronary angiography (n=63) and 2) patients who did undergo angiography (n=213). The latter group was reclassified into patients with significant CAD or normal angiograms/nonsignificant CAD. Read More

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November 2018

Acyclovir Neurotoxicity in a Peritoneal Dialysis Patient: Report of a Case and Review of the Pharmacokinetics of Acyclovir.

Am J Case Rep 2018 Dec 9;19:1459-1462. Epub 2018 Dec 9.

Pharmacy Section, Jerry L Pettis Veterans Memorial Medical Center, Loma Linda, CA, USA.

BACKGROUND The elderly population in the United States and the world is rapidly increasing. With aging, immunity and kidney function decrease, thus predisposing people to viral illnesses for which there is no effective prophylaxis. Herpes zoster afflicts the elderly and other immunocompromised patients, like those with end-stage renal disease, transplant recipients, and cancer patients, causing significant morbidity and sometimes mortality. Read More

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December 2018

Choice of Catheter Size for Infants in Continuous Renal Replacement Therapy: Bigger Is Not Always Better.

Pediatr Crit Care Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Viale Ferdinando Rodolfi 37, Vicenza, Italy.

Objectives: Renal replacement therapy in infants and small children is the treatment of choice for severe oligoanuric renal dysfunction, with an increasing consensus that early initiation might contribute to preventing acute kidney injury complications. Safer renal replacement therapy devices specifically designed for neonates may contribute to ameliorating outcomes and increasing chances of survival. One of the crucial factors to achieve an effective renal replacement therapy in small infants is adequate vascular access. Read More

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December 2018

A novel scoring system for assessing the severity of electrolyte and acid-base disorders and predicting outcomes in hospitalized patients.

J Investig Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.

Electrolyte and acid-base disorders are commonly seen in critically ill and other hospitalized patients. A scoring system is needed to assess the severity of electrolyte and acid-base disorders and to predict outcome in hospital patients. Herein, we prospectively enrolled a total of 322,046 patients, including 84,700 patients in the derivation cohort and 237,346 in the validation cohort, in a large, tertiary hospital in East China from 2014 to 2017. Read More

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December 2018
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Investigating the Relationship between Cerebral Blood Flow and Cognitive Function in Hemodialysis Patients.

J Am Soc Nephrol 2018 Dec 7. Epub 2018 Dec 7.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

Background: The immediate and longer-term effects of hemodialysis on cerebral circulation, cerebral structure, and cognitive function are poorly understood.

Methods: In a prospective observational cohort study of 97 adults (median age 59 years) receiving chronic hemodialysis, we used transcranial Doppler ultrasound to measure cerebral arterial mean flow velocity (MFV) throughout dialysis. Using a well validated neuropsychological protocol, we assessed cognitive function during and off dialysis and after 12 months of treatment. Read More

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December 2018

Survival among Veterans Obtaining Dialysis in VA and Non-VA Settings.

J Am Soc Nephrol 2018 Dec 7. Epub 2018 Dec 7.

Health Services Research and Development, Durham Veterans Affairs Health Care System, Durham, North Carolina.

Background: Outcomes of veterans with ESRD may differ depending on where they receive dialysis and who finances this care, but little is known about variation in outcomes across different dialysis settings and financial arrangements.

Methods: We examined survival among 27,241 Veterans Affairs (VA)-enrolled veterans who initiated chronic dialysis in 2008-2011 at () VA-based units, () community-based clinics through the Veterans Affairs Purchased Care program (VA-PC), () community-based clinics under Medicare, or () more than one of these settings ("dual" care). Using a Cox proportional hazards model, we compared all-cause mortality across dialysis settings during the 2-year period after dialysis initiation, adjusting for demographic and clinical characteristics. Read More

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December 2018

Insights on Peritoneal Dialysis in China.

Perit Dial Int 2018 12;38(Suppl 2):S16-S18

The series of papers that are included in this China Supplement to chart peritoneal dialysis (PD) research over the last several years in that country, provide detailed analysis of a large de-identified dataset from the Baxter Patient Support Program, and include 2 papers that describe clinical experiences relevant to the local context. These studies present a fascinating insight into the practice of PD in China, adding considerably to the sum of worldwide PD experience. China presents important opportunities for clinical research to answer key questions relevant to our therapy. Read More

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December 2018

Longitudinal progression trajectory of random urine creatinine as a novel predictor of ESRD among patients with CKD.

Clin Chim Acta 2018 Dec 7. Epub 2018 Dec 7.

Kidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital and College of Medicine, China Medical University, Taichung, Taiwan; Big Data Center, China Medical University Hospital and College of Medicine, China Medical University, Taichung, Taiwan. Electronic address:

Background: The clinical importance of random urine creatinine concentration in CKD population remains undetermined. Earlier studies found that lower 24-h urine creatinine excretion was associated with the risk of ESRD and all-cause mortality among CKD patients.

Methods: We modeled the longitudinal trajectories of serial random urine creatinine among 4689 CKD patients enrolled in a national registry-based pre-ESRD program between 2003 and 2015 at a tertiary medical center. Read More

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December 2018

Vitality Measured as Self-reported Energy Level and Clinical Outcomes in Hemodialysis Patients: The Japanese Dialysis Outcomes and Practice Pattern Study (J-DOPPS).

Am J Kidney Dis 2018 Dec 7. Epub 2018 Dec 7.

Center for Innovative Research for Communities and Clinical Excellence (CIRC(2)LE), Fukushima Medical University, Fukushima, Japan; Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Rationale & Objective: The infrequent assessment of vitality in clinical practice may be partially due to an inadequate understanding of vitality and the lack of a concise method of assessing it. This study aimed to examine the association of a simple 1-item "vitality" question measuring self-reported energy level with clinical outcomes.

Study Design: Prospective cohort study. Read More

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December 2018

Human atrial natriuretic peptide for acute kidney injury in adult critically ill patients: A multicenter prospective observational study.

J Crit Care 2018 Dec 1. Epub 2018 Dec 1.

Kyoto University Health Service, Yoshida Hon-machi, Sakyo-ku, Kyoto, Japan.

Purpose: Acute kidney injury (AKI) is common in the intensive care unit (ICU). Selected clinical studies have implied human atrial natriuretic peptide (hANP) improves renal function; however, the treatment effects for AKI are unclear.

Methods: A multicenter prospective observational study in 13 Japanese ICUs. Read More

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December 2018

Incorporating indigenous knowledge in health services: a consumer partnership framework.

Public Health 2018 Oct 24. Epub 2018 Oct 24.

Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia; Division of Medicine, Royal Darwin Hospital, Darwin, NT, Australia; Top-End Renal Service, Darwin, NT, Australia. Electronic address:

Objectives: Healthcare policy and planning should be informed by a partnership between healthcare services and healthcare users. This is critical for people who access care frequently such as indigenous Australians who have a high burden of chronic kidney disease. This study aimed to explore the most appropriate ways of enhancing services by incorporating renal patients' expectations and satisfaction of care in Australia's Northern Territory. Read More

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October 2018

Repair of descending thoracic aortic aneurysms with Ankura Thoracic Stent Graft.

J Vasc Surg 2018 Oct 24. Epub 2018 Oct 24.

Department of Cardiothoracic and Vascular Surgery, Evangelismos General Hospital of Athens, Athens, Greece.

Objective: The aim of the study was to present the results for patients with atherosclerotic aneurysm of the descending thoracic aorta (DTA) treated with a novel thoracic stent graft.

Methods: A single-center retrospective review of prospectively collected data was performed. We extracted demographic variables as well as atherosclerotic comorbidities and operation-related and imaging-related data from patients' medical records. Read More

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October 2018
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Comparative outcomes of vascular access in patients older than 70 years with end-stage renal disease.

J Vasc Surg 2018 Oct 24. Epub 2018 Oct 24.

Division of Vascular Surgery, Department of Surgery, Kyungpook National University Hospital, Daegu, South Korea.

Objective: The advantage of arteriovenous fistulas (AVFs) in older patients requiring dialysis is controversial. We reviewed our vascular access experience in patients ≥70 years of age (older group) compared with younger patients.

Methods: We analyzed consecutive patients who underwent access surgery between 2013 and 2016. Read More

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October 2018

Outcomes of basilic vein transposition versus polytetrafluoroethylene forearm loop graft as tertiary vascular access.

J Vasc Surg 2018 Oct 24. Epub 2018 Oct 24.

Division of Vascular Surgery, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: Radial-cephalic arteriovenous fistula and brachial-cephalic arteriovenous fistula are the first and second choices for creating vascular access in dialysis patients as recommended by the National Kidney Foundation Kidney Disease Outcomes Quality Initiative. Basilic vein transposition or use of a forearm (polytetrafluoroethylene [PTFE]) loop graft is recommended thereafter. The aim of this study was twofold: first, to compare the outcomes and patency rates of patients treated with a basilic vein transposition with those of patients treated with a PTFE loop; and second, to identify patient-related factors of influence on patency rates. Read More

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October 2018

Immediate-access grafts provide comparable patency to standard grafts, with fewer reinterventions and catheter-related complications.

J Vasc Surg 2018 Oct 24. Epub 2018 Oct 24.

Division of Vascular Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pa.

Background: No independent comparisons, with midterm follow-up, of standard arteriovenous grafts (SAVGs) and immediate-access arteriovenous grafts (IAAVGs) exist. The goal of this study was to compare "real-world" performance of SAVGs and IAAVGs.

Methods: Consecutive patients who underwent placement of a hemodialysis graft between November 2014 and April 2016 were retrospectively identified from the electronic medical record and Vascular Quality Initiative database at two tertiary centers. Read More

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October 2018

Population pharmacokinetics of tazobactam/ceftolozane in Japanese patients with complicated urinary tract infection and complicated intra-abdominal infection.

J Infect Chemother 2018 Dec 4. Epub 2018 Dec 4.

Department of Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc., Kenilworth, NJ, USA.

Tazobactam/ceftolozane is a combination of a β-lactamase inhibitor and a cephalosporin antibiotic, with recommended dosage for patients with normal renal function of tazobactam 0.5 g/ceftolozane 1 g administered as a 1-h intravenous infusion every 8 h. The doses in patients with moderate and severe renal impairment are recommended to be reduced by half and 1/4th, respectively. Read More

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December 2018

Relation of Race, Apparent Disability, and Stroke Risk With Warfarin Prescribing for Atrial Fibrillation in Patients Receiving Maintenance Hemodialysis.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Chronic Disease Research Group, Hennepin Healthcare Research Institute, Minneapolis, Minnesota.

Little is known about how warfarin is prescribed for stroke prevention in maintenance dialysis patients with chronic atrial fibrillation (AF). We examined patterns of warfarin use, and associated factors, after AF diagnosis. This retrospective cohort analysis studied US Medicare patients receiving maintenance dialysis January 1, 2008, to June 30, 2010. Read More

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November 2018

With a median survival of only 2 to 3 years, should dialysis patients more than 50 years old exclusively have transcatheter valves?

J Thorac Cardiovasc Surg 2018 Nov 2. Epub 2018 Nov 2.

Department of Surgery, Baystate Medical Center, Springfield, Mass; University of Massachusetts Medical School-Baystate, Springfield, Mass.

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November 2018

Clinical Evaluation of the Cook Advance Enforcer 35 Focal-Force PTA Balloon Catheter for Treatment of Hemodialysis Fistula Stenoses: A Feasibility Study.

J Vasc Interv Radiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Cook, Bloomington, Indiana.

Purpose: A prospective, single-center, single-arm feasibility study evaluated procedural and short-term performance of the Advance Enforcer 35 focal-force percutaneous transluminal angioplasty (PTA) balloon catheter in treating stenoses of mature native arteriovenous (AV) hemodialysis access circuits.

Materials And Methods: Twenty-eight patients undergoing treatment for stenosis of a mature native AV hemodialysis access circuit were enrolled at a single institution. Angiographic assessments of the study lesion were required at baseline and after the procedure. Read More

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December 2018

Leading Integrated Kidney Care Entities of the Future.

Adv Chronic Kidney Dis 2018 Nov;25(6):523-529

Dialysis Clinic, Inc, Nashville, TN and Division of Nephrology, Tufts Medical Center, Boston, MA. Electronic address:

The leaders of 20th century kidney failure treatment took chances; 21st century leaders of integrated kidney care must do the same. Some risks are clinical, some are organizational, and some are financial. Decent and constructive leadership entails humility. Read More

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November 2018

Leading the Dialysis Unit: Role of the Medical Director.

Adv Chronic Kidney Dis 2018 Nov;25(6):499-504

University of Cincinnati, Cincinnati, OH; and Indiana University Health, Indianapolis, IN. Electronic address:

The responsibilities of a dialysis unit medical director are specified in the ESRD Conditions for Coverage and encompass multiple quality, safety, and educational domains. Many of these responsibilities require leadership skills that are neither intuitive nor acquired as part of the medical director's training. An effective medical director is able to shape the culture of the dialysis facility such that patients and staff feel free to communicate their concerns regarding suboptimal processes without fear of retribution, and there is a continuous iterative process of quality improvement and safety, which values input from all stakeholders. Read More

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November 2018

Leading a Dialysis Organization: Role and Responsibilities of the Chief Medical Officer (Nephrologist Leadership in a Dialysis Provider Organization).

Adv Chronic Kidney Dis 2018 Nov;25(6):485-489

Satellite Healthcare, San Jose, CA. Electronic address:

The early beginning of the end-stage kidney disease program with the introduction of the Medicare Act of 1973 was marked by nephrologist entrepreneurs pioneering dialysis centers to deliver dialysis addressing the clinical needs of patients in a collaborative effort between physicians and nurses. As the number of patients grew, a system reliably providing dialysis treatments for many more patients than was ever anticipated was required to enable the demands of the increased scale. Solutions appropriate to respond to the growing needs of out-patient dialysis centers were developed combining emerging technology, clinical advances, and operational efficiency. Read More

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November 2018

Leadership as a Division Chief of Nephrology.

Authors:
Eleanor Lederer

Adv Chronic Kidney Dis 2018 Nov;25(6):480-484

Interim Chair of Medicine, Division Chief of Nephrology and Hypertension, University of Louisville School of Medicine, St Louisville, KY, and ACOS for Research and Development, Robley Rex VA Medical Center, Louisville, KY. Electronic address:

The position of chief of a division of nephrology in an academic medical center is a hands-on job, offering the opportunity to influence the future of the field through the creation of unique clinical, research, and education programs. Today, most academic centers face significant financial challenges, thus the division chief must develop a variety of skills to accomplish his or her goals. Interactions and relationships with the leadership of the academic center, including the hospital executives, can facilitate or impede progress on proposed projects; therefore, aligning the goals of the division with the goals of leadership is an imperative. Read More

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November 2018

A History of Leadership in Dialysis: Perspectives From Seasoned Leaders.

Authors:
Dugan W Maddux

Adv Chronic Kidney Dis 2018 Nov;25(6):474-479

Fresenius Medical Care North America, Waltham, MA. Electronic address:

The history of chronic dialysis in the United States highlights the impact nephrology leaders have on improving kidney disease care. Belding Scribner and his Seattle team transformed end-stage renal disease from a fatal illness to a treatable condition with use of the first successful Scribner shunt in 1960. Advances in dialysis machines emerged from Les Babb and Richard Drake finding ways to treat more patients. Read More

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November 2018

Decellularized Carotid Artery Functions as an Arteriovenous Graft.

J Surg Res 2019 Feb 27;234:33-39. Epub 2018 Sep 27.

Department of Physiology, Basic Medical College of Zhengzhou University, Henan, China. Electronic address:

Background: Prosthetic arteriovenous grafts (AVG) continue to have a high rate of failure in clinical use, yet there is continued clinical demand for them. However, there is no small animal model of AVG to test novel tissue-engineered vascular grafts. We established a new rat arteriovenous graft model to compare the healing of decellularized carotid artery (CA) to autologous CA. Read More

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February 2019

Iris hooks versus a pupil expansion ring: Operating times, complications, and visual acuity outcomes in small pupil cases.

J Cataract Refract Surg 2018 Dec 7. Epub 2018 Dec 7.

From the Epsom and St. Helier University National Health Service Trust, London, United Kingdom.

Purpose: To compare iris hooks and a pupil expansion ring (Malyugin ring) in eyes with a small pupil.

Setting: Epsom and St. Helier University National Health Service Trust, London, United Kingdom. Read More

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December 2018

Estimations and analysis of medical waste amounts in the city of Istanbul and proposing a new approach for the estimation of future medical waste amounts.

Waste Manag 2018 Nov 9;81:168-176. Epub 2018 Oct 9.

Department of Environmental Protection and Control, Istanbul Metropolitan Municipality, Istanbul, Turkey. Electronic address:

The goal of this work was to estimate the yearly total medical waste amounts for hospitals and other healthcare institutions, and yearly averages of daily unit medical waste amounts per hospital bed using the data from medical waste collection, treatment and disposal establishments for last 18 years in Istanbul, Turkey. The estimations were based on the number of medical waste bags that were collected from hospitals and healthcare institutions and then transferred to either a medical waste incinerator or to an autoclave sterilization facility in Istanbul during the last 18 years. Hospitals were divided into 5 categories; dialysis, specialty, educational state university and state hospitals, non-educational state and non-educational private hospitals. Read More

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November 2018

BK virus nephropathy and multiorgan involvement in a child with heart transplantation
.

Clin Nephrol 2018 Dec 11. Epub 2018 Dec 11.

BK virus is a known cause of renal failure in kidney transplant recipients, but there is little data regarding its effect on native kidneys in heart transplant patients. Here, we describe the case of a child who underwent heart transplantation and was later diagnosed with BK virus with multiorgan involvement. This patient was diagnosed with dilated cardiomyopathy at 4 months of age and underwent heart transplantation at the age of 5 years. Read More

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December 2018