175,824 results match your criteria Dialysis & Transplantation[Journal]


Spondylodiscitis in end-stage renal disease: a systematic review.

J Neurosurg Spine 2019 Feb 15:1-9. Epub 2019 Feb 15.

1Department of Neurological Surgery, University of Miami, Miami, Florida; and.

OBJECTIVEDiscitis and osteomyelitis are seen in end-stage renal disease (ESRD) patients due to repeated vascular access for hemodialysis and urinary tract infections leading to recurrent bacteremia. Discitis and osteomyelitis are underdiagnosed due to the nonspecific initial presentation of back pain. In this article, we review the literature for better understanding of the problem and the importance of early diagnosis by primary care physicians and nephrologists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2018.9.SPINE18824DOI Listing
February 2019

Factors associated with early seizures after surgery of unruptured intracranial aneurysms.

Clin Neurol Neurosurg 2019 Feb 8;178:93-96. Epub 2019 Feb 8.

Department of Cerebrovascular Surgery, International Medical Center, Saitama Medical University, Hidaka, Japan. Electronic address:

Objective: The aim of the study was to better define the incidence of and risk factors for early seizures after repair of unruptured intracranial aneurysms in modern microsurgical techniques.

Patients And Methods: The medical records of 414 consecutive patients who underwent neck clipping of unruptured intracranial aneurysms in our institution over a 5-year period were retrospectively reviewed. Clinical and neuroimaging variables were analyzed to investigate putative predictors of perioperative seizures using multivariate logistic regression analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clineuro.2019.02.007DOI Listing
February 2019

Characteristics of visit-to-visit blood pressure variability in hemodialysis patients.

Hypertens Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Endocrinology and Hypertension, Tokyo Women's Medical University, Tokyo, Japan.

Visit-to-visit blood pressure variability (VVBPV) is an independent risk factor for cardiovascular morbidity and mortality in the general population. Hemodialysis (HD) patients have a poor prognosis due to an increased prevalence of cardiovascular disease. Intradialytic hypotension is associated with excess mortality, but whether VVBPV influences mortality is still unclear in HD patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41440-019-0231-9DOI Listing
February 2019

Prognostic factors in patients with active non-variceal upper gastrointestinal bleeding.

Arab J Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran. Electronic address:

Background And Study Aims: Acute upper gastrointestinal bleeding is one of the main causes of hospitalisation. The purpose of this study was to determine the prognostic factors in non-variceal upper gastrointestinal bleeding.

Patients And Methods: Clinical outcomes, demographic and laboratory variables of the subjects were collected from the HIS software and national code with the SQL format from three hospitals in Qazvin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajg.2019.01.001DOI Listing
February 2019

Effect of inflow arterial calcification on arteriovenous fistula maturation.

Ann Vasc Surg 2019 Feb 12. Epub 2019 Feb 12.

Radiology, Seoul Metropolitan Government -Seoul National University Boramae Medical Center, Seoul, Korea.

Background: The aim of this study was to investigate the effect of preexisting calcification in the inflow artery on maturation and flow volume of an arteriovenous fistula (AVF).

Materials And Methods: Patients who underwent AVF creation for hemodialysis were prospectively recruited between March and November 2017. On preoperative duplex ultrasound, calcification in the arterial media within 5cm of the planned anastomosis area was assessed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.avsg.2018.10.057DOI Listing
February 2019

Donor organ intervention before kidney transplantation: Head-to-head comparison of therapeutic hypothermia, machine perfusion, and donor dopamine pretreatment. What is the evidence?

Am J Transplant 2018 Jul 31. Epub 2018 Jul 31.

Department of Immunology, University of Heidelberg, Germany.

Therapeutic hypothermia, hypothermic pulsatile machine perfusion (MP), and renal-dose dopamine administered to stable brain-dead donors have shown efficacy to reduce the dialysis requirement after kidney transplantation. In a head-to-head comparison of the three major randomized controlled trials in this field, we estimated the number-needed-to-treat for each method, evaluated costs and inquired into special features regarding long-term outcomes. The MP and hypothermia trials used any dialysis requirement during the first post-operative week, while the dopamine trial assessed >1 dialysis session as primary endpoint. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajt.15317DOI Listing

Global prevalent use, trends and practices in haemodiafiltration.

Nephrol Dial Transplant 2019 Feb 14. Epub 2019 Feb 14.

International Strategic Development, Fresenius Medical Care, Bad Homburg, Germany.

Online haemodiafiltration (HDF) represents today the most advanced and innovative form of renal replacement therapy (RRT). Recent controlled trials tend to prove its superiority over conventional haemodialysis on hard clinical end points provided that the right convective dose was delivered. In this article we report on present prevalent use and epidemiologic trends of HDF worldwide as well as on practice patterns in HDF prescription. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ndt/gfz005DOI Listing
February 2019

Con: vascular access surveillance in mature fistulas: is it worthwhile?

Nephrol Dial Transplant 2019 Feb 14. Epub 2019 Feb 14.

Department of Medicine, Division of Nephrology, University Health Network-Toronto General Hospital, Toronto, ON, Canada.

The risks and benefits of hemodialysis arteriovenous (AV) access surveillance have been debated since the introduction of AV access surveillance techniques. The debate is fuelled by the lack of robust, high-quality evidence with consistent and comparable patient-important outcomes. Additionally, there is a lack of clarity regarding the diagnostic cut points for AV access stenosis using the various surveillance techniques, questions about the appropriateness of the 'knee-jerk' response to intervention on a stenosis >50% regardless of the presence of clinical indicators and whether the intervention results in desired patient-important outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ndt/gfz004DOI Listing
February 2019

Outcome of posterior urethral valve in 64 children. Single center experience of 22 years.

Minerva Urol Nefrol 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatric Nephrology, Faculty of Medicine, Kocaeli University, Kocaeli, Turchia.

Background: Posterior urethral valve (PUV) is the most serious form of congenital anomalies of kidney and urinary tract (CAKUT) in boys with significant risk of progression to chronic kidney disease (CKD). We present our long term results in children with PUV.

Methods: Retrospective chart review of 113 children with PUV followed within the years of 1996-2018 was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.23736/S0393-2249.19.03272-7DOI Listing
February 2019
2 Reads

Impact on renal resistive index of diabetes in renal transplant donors and recipients: A retrospective analysis of 1827 kidney transplant recipients.

J Clin Hypertens (Greenwich) 2019 Feb 14. Epub 2019 Feb 14.

Néphrologie-Immunologie Clinique, Hôpital Bretonneau, CHRU Tours, Tours, France.

High renal resistive index (RI) is observed in diabetes and is associated with poor patient survival, but whether it is primarily due to renal vascular resistance or systemic vascular alterations is unclear. The respective impact of kidney transplant from diabetic donors or to diabetic recipients on RI would shed some light on this issue. The objective of the study was to analyze the impact of donor and recipient diabetes on RI in order to understand the respective impact of the kidney and the vascular environment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jch.13492DOI Listing
February 2019

Flash Glucose Monitoring in Subjects with Diabetes on Hemodialysis: A Pilot Study.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):848-851

Department of Clinical Diabetology and Endocrinology, Chellaram Diabetes Institute, Pune, Maharashtra, India.

Background: In patients with diabetes related end-stage renal disease (ESRD) on hemodialysis, blood glucose management can be challenging due to the kinetics of glucose and insulin in addition to other factors. The glucose monitoring systems which measure glucose levels continuously may be useful to study the glucose profile of patients with diabetes undergoing hemodialysis. Our study is designed to use ambulatory glucose profile to study the glucose pattern - during, before, and after a session of hemodialysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijem.IJEM_520_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330844PMC
February 2019

Prevalence of autonomic dysfunction among pre-dialysis chronic kidney disease patients in a tertiary hospital, South East Nigeria.

Afr Health Sci 2018 Dec;18(4):950-957

University of Nigeria teaching hospital, College of Medicine, Ituku/Ozalla, Enugu, Nigeria, Medicine.

Background: Autonomic dysfunction (AD) has been recognized as an important contributor to the poor outcome in chronic kidney disease (CKD) patients. Several studies have reported abnormalities in heart rate variability (HRV) among these patients.

Objectives: To determine the prevalence of Autonomic Dysfunction (AD) in pre-dialysis Chronic Kidney Disease (CKD) patients in a tertiary hospital in South East Nigeria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4314/ahs.v18i4.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354868PMC
December 2018

Central Venous Stenosis, Access Outcome and Survival in Patients undergoing Maintenance Hemodialysis.

Clin J Am Soc Nephrol 2019 Feb 14. Epub 2019 Feb 14.

West London Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare National Health Service Trust, London, UK

Background And Objectives: Central venous catheters have traditionally provided access for urgent hemodialysis, but are also sometimes advocated as an option for older or more comorbid patients. Adverse effects of this type of dialysis access include central venous stenosis, for which the risk factors and consequences are incompletely understood.

Design, Setting, Participants, & Measurements: We conducted two studies within the same population cohort, comprising all patients starting hemodialysis in a single center from January 2006 to December 2013. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2215/CJN.07010618DOI Listing
February 2019

Overall and Site-Specific Cancer Mortality in Patients on Dialysis and after Kidney Transplant.

J Am Soc Nephrol 2019 Feb 14. Epub 2019 Feb 14.

School of Public Health, University of Sydney, Sydney, Australia.

Patients with ESRD have a substantially increased cancer risk, but few studies have examined the patterns of cancer mortality along a patient's journey from dialysis to transplantation.

Methods: We identified all Australian patients on dialysis and patients with transplants from 1980 to 2014 from the Australia and New Zealand Dialysis and Transplant Registry. Using standardized mortality ratios (SMRs), we compared cancer mortality among patients on dialysis and patients with transplants versus the general population (overall and by age, sex, year, and site); we also performed a subgroup analysis excluding patients with preexisting cancers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2018090906DOI Listing
February 2019
9.343 Impact Factor

Revisiting racial differences in ESRD due to ADPKD in the United States.

BMC Nephrol 2019 Feb 14;20(1):55. Epub 2019 Feb 14.

Section of Nephrology, Yale University School of Medicine, New Haven, CT, 06520, USA.

Introduction: Autosomal dominant polycystic kidney disease (ADPKD) affects all races. Whether the progression of ADPKD varies by race remains unclear.

Methods: In this retrospective cohort study from 2004 to 2013 non-Hispanic blacks and non-Hispanic whites of all ages classified in the US Renal Data System (USRDS) with incident ESRD from ADPKD (n = 23,647), hypertension/large vessel disease (n = 296,352), or diabetes mellitus (n = 451,760) were stratified into five-year age categories ranging from < 40 to > 75 (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1241-1DOI Listing
February 2019

Does CMS' Meaningful Measures initiative boil down to cost-benefit analysis?

Authors:
Jackson Williams

Am J Manag Care 2019 02;25(2):59-60

Dialysis Patient Citizens, 1012 14th St NW, Ste 1475, Washington, DC 20005. Email:

Cost-benefit analysis for quality measures has emerged as the cornerstone of CMS' Meaningful Measures initiative. Read More

View Article

Download full-text PDF

Source
February 2019

Inflammatory Activity of Tumoral Calcinosis in a Patient With Fever of Unknown Origin.

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the Clinics of Nuclear Medicine, and.

Unexpected inflammatory activity of tumoral calcinosis periarticular to the shoulders and hips in a man with recurrent fever of unknown origin and dialysis-dependent kidney insufficiency was revealed by FDG PET/CT. In absence of other pathologies, the calcinosis was deemed to be the cause of the fever. An infectious or malignant disease could be ruled out, so further therapeutic steps were enabled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RLU.0000000000002497DOI Listing
February 2019

The effects of perioperative intravenous fluid administration strategy on renal outcomes in patients undergoing cardiovascular surgery: An observational study.

Medicine (Baltimore) 2019 Feb;98(7):e14383

Department of Anesthesiology and Pain Medicine.

We assessed whether perioperative fluid management with balanced solutions and a limited volume of hydroxyethyl starch (renal-protective fluid management [RPF] strategy) could improve renal outcomes after cardiovascular surgery.For this retrospective observational study, we evaluated 2613 patients who underwent cardiovascular surgery from January 1, 2010 to December 31, 2013. The control group were given intravenous fluids with saline-based solutions and unlimited volumes of hydroxyethyl starch solutions and the RPF group were given intravenous fluids with RPF. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014383DOI Listing
February 2019

Living or deceased donor kidney transplantation in children.

Curr Opin Pediatr 2019 Feb 11. Epub 2019 Feb 11.

Division of Pediatric Nephrology, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA.

Purpose Of Review: Kidney transplantation is the preferred treatment modality for children with end-stage renal disease. In this review, we discuss the factors affecting the selection of the appropriate donor to ensure the best possible short and long-term outcomes.

Recent Findings: Outcomes of pediatric renal transplantation from living donors are superior to those obtained from deceased donors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOP.0000000000000740DOI Listing
February 2019

Oral nutritional supplements and 30-day readmission rate in hypoalbuminemic maintenance hemodialysis patients.

Hemodial Int 2019 Feb 14. Epub 2019 Feb 14.

Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, USA.

Introduction: Hemodialysis (HD) patients are hospitalized nearly twice yearly, and 35% of these patients are rehospitalized within 30-days postdischarge. We hypothesized that monitored oral nutritional supplementation (ONS) during HD treatment may decrease readmissions.

Methods: A cohort of maintenance HD patients, treated at a large dialysis organization, who were hospitalized with a postdischarge albumin of ≤3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/hdi.12694DOI Listing
February 2019

Aiming for the optimal bicarbonate prescription for maintenance hemodialysis therapy in end-stage renal disease.

Hemodial Int 2019 Feb 14. Epub 2019 Feb 14.

General Hospital of Thessaloniki "Agios Pavlos", Nephrology Department, Thessaloniki, Greece.

Introduction: Acidemia and alkalemia, as a result of gradual depletion of the body's buffers followed by rapid repletion during hemodialysis (HD), are linked to adverse consequences. We examined the acid-base status with dialysis bath of higher bicarbonate (HC03 ) concentration or standard HC03 bath plus oral HC03 supplementation.

Methods: A total of 60 stable HD patients (pts) were evaluated according to their pre-dialysis acid-base status both before the first and the second session of the week dialyzed against standard base dialysate of 35 mmol/L. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/hdi.12710DOI Listing
February 2019

Role of allograft inflammatory factor-1 in the regulation of inflammation and oxidative stress in primary peritoneal mesothelial cells.

Cell Biol Int 2019 Feb 13. Epub 2019 Feb 13.

Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, People's Republic of China.

Peritoneal dialysis (PD) is often used to treat patients with end stage renal disease, and its long-term complications include excessive inflammation and oxidative stress. Allograft inflammatory factor 1 (AIF-1), as a cytoplasmic protein, is originally identified from infiltrating macrophages, and it was associated with inflammation in the cells other than macrophages, such as endothelial cells and vascular smooth muscle cells. To clarify the molecular mechanisms of AIF-1-modulated pathological changes in the peritoneum during PD, we first detected the AIF-1 expression in peritoneal tissues from PD mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbin.11115DOI Listing
February 2019

Impact of Discharge Location After Transcatheter Aortic Valve Replacement on 1-Year Outcomes in Women: Results From the WIN-TAVI Registry.

Can J Cardiol 2019 Feb 12;35(2):199-207. Epub 2018 Dec 12.

Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address:

Background: Several clinical and procedural factors determine outcomes after transcatheter aortic valve replacement (TAVR), but data are scarce on the impact of post-TAVR discharge disposition on long-term outcomes. We sought to analyse whether discharge location after TAVR is associated with 1-year outcomes in women undergoing contemporary TAVR.

Methods: The Women's INternational Transcatheter Aortic Valve Implantation (WIN-TAVI) registry is the first all-female TAVR registry to study the safety and performance of contemporary TAVR in women (n = 1019). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cjca.2018.11.035DOI Listing
February 2019

Improved long-term survival with home hemodialysis compared with institutional hemodialysis and peritoneal dialysis: a matched cohort study.

BMC Nephrol 2019 Feb 13;20(1):52. Epub 2019 Feb 13.

Department of Clinical Sciences Lund, University, Skane University Hospital, Nephrology Lund, Lund, Sweden.

Background: The survival rate for dialysis patients is poor. Previous studies have shown improved survival with home hemodialysis (HHD), but this could be due to patient selection, since HHD patients tend to be younger and healthier. The aim of the present study is to analyse the long-term effects of HHD on patient survival and on subsequent renal transplantation, compared with institutional hemodialysis (IHD) and peritoneal dialysis (PD), taking age and comorbidity into account. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1245-xDOI Listing
February 2019

Lung Ultrasound B-lines Occurrence in Relation to Left Ventricular Function and Hydration Status in Hemodialysis Patients.

Medicina (Kaunas) 2019 Feb 12;55(2). Epub 2019 Feb 12.

Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, 40-027 Katowice, Poland.

Background And Objective: Reliable assessment of the fluid status in hemodialysis (HD) patients is often difficult. A lung ultrasound with an assessment of the B-lines ("lung comets" (LCs)) number is a novel hydration status measure. However, the occurrence of left ventricular dysfunction may have a significant effect on pulmonary congestion and further modulate the LC number. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/medicina55020045DOI Listing
February 2019

Osteocalcin (bone GLA protein) levels, vascular calcifications, vertebral fractures and mortality in hemodialysis patients with diabetes mellitus.

J Nephrol 2019 Feb 13. Epub 2019 Feb 13.

Laboratory Medicine Unit, Department of Medicine, University of Padova, Padua, Italy.

Background And Aims: Diabetes mellitus is recognized as one of the major causes of end stage kidney disease. Bone Gla protein (BGP) is a vitamin K-dependent protein involved in bone mineralization and vascular calcifications (VC). Our goal was to characterize BGP and undercarboxylated BGP (ucBGP) in DM patients on HD, compared to HD patients without DM, and their association with vascular and bone disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40620-019-00595-1DOI Listing
February 2019

The associations of fat tissue and muscle mass indices with all-cause mortality in patients undergoing hemodialysis.

PLoS One 2019 13;14(2):e0211988. Epub 2019 Feb 13.

Department of Internal Medicine, Matsunami General Hospital, Gifu, Japan.

Protein-energy wasting, which involves loss of fat and muscle mass, is prevalent and is associated with mortality in hemodialysis (HD) patients. We investigated the associations of fat tissue and muscle mass indices with all-cause mortality in HD patients. The study included 162 patients undergoing HD. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211988PLOS
February 2019

Exercise Interventions for Improving Objective Physical Function in End-Stage Kidney Disease Patients on Dialysis: A Systematic Review and Meta-Analysis.

Am J Physiol Renal Physiol 2019 Feb 13. Epub 2019 Feb 13.

Institute for Physical Activity and Nutrition, Deakin University, Australia.

Background: Patients with end stage kidney disease on dialysis have increased mortality and reduced physical activity contributing to impaired physical function. While exercise programmes have demonstrated a positive effect on physiological outcomes such as cardiovascular function and strength, there is a reduced focus on physical function. The aim of this review was to determine whether exercise programmes improve objective measures of physical function indicative of activities of daily living for end stage kidney disease patients on dialysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajprenal.00317.2018DOI Listing
February 2019

[Narrative Medicine can reduce opposition to organ removal for transplantation].

G Ital Nefrol 2019 Feb;36(1)

Cattedra di Cardiochirurgia Università di Foggia.

In Italy in 2017 out of 2738 assessments of death, there was a 28.7% of oppositions of family members to the removal of organs post-mortem. This opposition is a serious limitation to the development of transplantation programs. Read More

View Article

Download full-text PDF

Source
February 2019
1 Read

Changes in Symptom Burden in Dialysis Patients Assessed Using a Symptom-Reporting Questionnaire in Clinic.

J Palliat Care 2019 Feb 13:825859719827315. Epub 2019 Feb 13.

1 Department of Medicine, The University of Melbourne, Melbourne, Australia.

Introduction:: To determine the prevalence, severity, and change in symptoms experienced by dialysis patients following the introduction of use of a symptom-reporting questionnaire in nephrology clinic.

Methods:: This is an observational study of 160 prevalent dialysis patients. Palliative care Outcome Scale symptom (POS-renal) questionnaires modified for patients with end-stage kidney disease were completed at baseline and follow-up (median 3 months), with results available to nephrologists at clinic appointments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0825859719827315DOI Listing
February 2019

Bridging adults and paediatrics with secondary hyperparathyroidism receiving haemodialysis: a pharmacokinetic-pharmacodynamic analysis of cinacalcet.

Br J Clin Pharmacol 2019 Feb 12. Epub 2019 Feb 12.

Amgen, Inc., Thousand Oaks, CA, USA.

Aims: To develop a pharmacokinetic (PK) and PK-pharmacodynamic (PK/PD) model of cinacalcet, in adults and paediatrics with secondary hyperparathyroidism (SHPT) on dialysis. To test covariates of interest, and to perform simulations to inform dosing in paediatrics with SHPT.

Methods: Cinacalcet PK, intact parathyroid hormone (iPTH) and corrected calcium (cCa) time courses following multiple daily oral doses (1-300 mg) were modelled using a nonlinear mixed effects modelling approach using data from 8 clinical studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bcp.13900DOI Listing
February 2019

Use of Intravenous Immunoglobulin Therapy at Unconventional Doses in Refractory Fulminant Systemic Lupus Erythematosus.

Eur J Case Rep Intern Med 2018 27;5(9):000934. Epub 2018 Sep 27.

Rare Diseases and Periodic Fevers Research Centre, Department of Internal Medicine, Agostino Gemelli University Hospital Foundation, Catholic University of the Sacred Heart, Rome, Italy.

The use of human intravenous immunoglobulins (IVIg) in systemic lupus erythematosus (SLE) currently relies on evidence from small case series and is mainly regarded as an off-label strategy in cases that are refractory to conventional therapies or poorly controlled with high doses of corticosteroids. Standard dosage regimens typically entail the administration of a total amount of 2 g/kg of IVIg divided into five consecutive days in order to minimize the risk of severe adverse events. We herein describe the case of a 28-year-old woman with a known history of antiphospholipid syndrome (APS) who was admitted to our hospital following fulminant onset of SLE in spite of ongoing immunosuppressive therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2018_000934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346821PMC
September 2018

Therapeutic targets for the anemia of predialysis chronic kidney disease: a meta-analysis of randomized, controlled trials.

J Investig Med 2019 Feb 11. Epub 2019 Feb 11.

Department of Nephrology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Anemia is one of the major complications in predialysis patients with chronic kidney disease (CKD). A clearer cognition of the prognostic impact of hemoglobin (Hb) or hematocrit (Hct) target on the outcomes of predialysis patients with CKD is significant. This article aims to establish the suitable hemoglobin target to provide clinical guidance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jim-2018-000915DOI Listing
February 2019

Removal of Protein-Bound Uremic Toxins during Hemodialysis Using a Binding Competitor.

Clin J Am Soc Nephrol 2019 Feb 12. Epub 2019 Feb 12.

Renal Research Institute, Research Division, New York, New York.

Background And Objectives: Current hemodialysis techniques fail to efficiently remove the protein-bound uremic toxins p-cresyl sulfate and indoxyl sulfate due to their high degree of albumin binding. Ibuprofen, which shares the same primary albumin binding site with p-cresyl sulfate and indoxyl sulfate, can be infused during hemodialysis to displace these toxins, thereby augmenting their removal.

Design, Setting, Participants, & Measurements: We infused 800 mg ibuprofen into the arterial bloodline between minutes 21 and 40 of a conventional 4-hour high-flux hemodialysis treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2215/CJN.05240418DOI Listing
February 2019

Risk factors for peptic ulcer disease in patients with end-stage renal disease receiving dialysis.

Kidney Res Clin Pract 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

Background: Compared to the general population, patients with end-stage renal disease have more gastrointestinal symptoms and a higher prevalence of peptic ulcer. Risk factors for peptic ulcer disease in patients with end-stage renal disease, however, remain poorly defined. This study aims to better identify those risk factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.23876/j.krcp.18.0060DOI Listing
February 2019

Conversion from acetate dialysate to citrate dialysate in a central delivery system for maintenance hemodialysis patients.

Kidney Res Clin Pract 2019 Feb 12. Epub 2019 Feb 12.

Division of Nephrology, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Korea.

Background: The objective of this study was to compare the impact of citrate dialysate (CD) and standard acetate dialysate (AD) in hemodialysis by central delivery system (CDS) on heparin demand, and clinical parameters.

Methods: We retrospectively evaluated 75 patients on maintenance hemodialysis with CDS. Patients underwent hemodialysis with AD over a six-month period (AD period), followed by another six-month period using CD (CD period). Read More

View Article

Download full-text PDF

Source
http://www.krcp-ksn.org/journal/view.html?doi=10.23876/j.krc
Publisher Site
http://dx.doi.org/10.23876/j.krcp.18.0045DOI Listing
February 2019
1 Read

Simvastatin-loaded solid lipid nanoparticles for enhanced anti-hyperlipidemic activity in hyperlipidemia animal model.

Int J Pharm 2019 Feb 9. Epub 2019 Feb 9.

Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan. Electronic address:

The objective of current study was to develop solid lipid nanoparticles-loaded with simvastatin (SIM-SLNs) and investigate their in vivo anti-hyperlipidemic activity in poloxamer-induced hyperlipidemia model. Nano-template engineering technique was used to prepare SIM-SLNs with palmityl alcohol as lipid core and a mixture of Tween 40/Span 40/Myrj 52 to stabilize the core. The prepared SIM-SLNs were evaluated for physicochemical parameters including particle diameter, surface charge, morphology, incorporation efficiency, thermal behaviour and crystallinity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2019.02.002DOI Listing
February 2019

Bilateral Mastodynia: An Unusual Presentation of Calciphylaxis.

Acta Med Port 2019 Feb 1;32(1):86. Epub 2019 Feb 1.

Senology Unit. Department of Gynecology and Obstetrics. Setúbal Medical Centre. Setúbal. Portugal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.20344/amp.10495DOI Listing
February 2019
1 Read

Joint association of vitamins D and K status with long-term outcomes in stable kidney transplant recipients.

Nephrol Dial Transplant 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Kidney transplant recipients (KTRs) experience substantial survival benefit compared with dialysis patients. However, their mortality and graft failure risk remain high. KTRs are often low in micronutrient status, including vitamins D and K. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ndt/gfy399DOI Listing
February 2019
3 Reads

SGLT-2 inhibitors and GLP-1 receptor agonists for nephroprotection and cardioprotection in patients with diabetes mellitus and chronic kidney disease. A consensus statement by the EURECA-m and the DIABESITY working groups of the ERA-EDTA.

Nephrol Dial Transplant 2019 Feb;34(2):208-230

Department of Nephrology, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.

Chronic kidney disease (CKD) in patients with diabetes mellitus (DM) is a major problem of public health. Currently, many of these patients experience progression of cardiovascular and renal disease, even when receiving optimal treatment. In previous years, several new drug classes for the treatment of type 2 DM have emerged, including inhibitors of renal sodium-glucose co-transporter-2 (SGLT-2) and glucagon-like peptide-1 (GLP-1) receptor agonists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ndt/gfy407DOI Listing
February 2019
1 Read

New agents to reduce cholesterol levels: implications for nephrologists.

Nephrol Dial Transplant 2019 Feb 11. Epub 2019 Feb 11.

Department of Nephrology and Dialysis, Alessandro Manzoni Hospital, ASST-Lecco, Italy.

Statins and ezetimibe effectively reduce the burden of cardiovascular (CV) disease in patients with chronic kidney disease (CKD). Unfortunately, many subjects still die or have CV events despite cholesterol-lowering therapy. This is particularly true in patients with more advanced CKD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ndt/gfz013DOI Listing
February 2019

Nutritional Management for Chronic Kidney Disease Patients who Undergo Bariatric Surgery: A Narrative Review.

Adv Nutr 2019 Jan;10(1):122-132

Department of Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Bariatric surgery (BS) may be effective for chronic kidney disease (CKD) patients by reducing microalbuminuria and proteinuria, and by facilitating their meeting inclusion criteria for kidney transplantation. However, nutritional management for this population is complex and specific guidelines are scarce. A literature search was performed to create dietetic practice for these patients based on the most recent evidence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/advances/nmy112DOI Listing
January 2019
1 Read
4.891 Impact Factor

Urine chloride self-measurement to monitor sodium chloride intake in patients with chronic kidney disease.

Clin Chem Lab Med 2019 Feb 12. Epub 2019 Feb 12.

CNR-IFC Research Unit of Reggio Calabria, c/o EUROLINE di Barillà Francesca, Via Vallone Petrara 55-57, 89124 Reggio Calabria, Italy.

Background Excessive sodium intake is a risk factor for hypertension, cardiovascular disease and the risk for kidney failure in chronic kidney disease (CKD) patients. Methods We tested the diagnostic performance and the feasibility of an inexpensive method based on urine chloride strips for self-monitoring sodium intake in a series of 72 CKD patients. Results Twenty-four hour urinary chloride as measured by the reactive strips and 24 h urinary sodium were interrelated (r=0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/cclm-2018-1227DOI Listing
February 2019
1 Read

Outcomes of Combined Hernia Repair and Peritoneal Dialysis Catheter Placement: A NSQIP Analysis.

Am Surg 2018 Oct;84(10):1604-1607

Department of Surgery, Harbor-UCLA Medical Center, Torrance, California, USA.

Historically, hernias were repaired before peritoneal dialysis (PD) catheter placement to obviate hernia complications, or after PD catheter placement once hernias became symptomatic or complicated. The aim of this study was to evaluate the outcomes and safety of combined hernia repair and PD catheter placement (HPD) compared with PD catheter placement alone. Within the NSQIP databases (2005-2014), 4406 patients who underwent PD catheter placement alone and 330 patients who underwent HPD were identified. Read More

View Article

Download full-text PDF

Source
October 2018

Appointment utilization as a trigger for palliative care introduction: A retrospective cohort study.

Palliat Med 2019 Feb 12:269216319828602. Epub 2019 Feb 12.

2 Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Background:: Chronic kidney disease palliative care guidelines would benefit from more diverse and objectively defined health status measures.

Aim:: The aim is to identify high-risk patients from administrative data and facilitate timely and uniform palliative care involvement.

Design:: It is a retrospective cohort study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0269216319828602DOI Listing
February 2019

Mycobacterium fortuitum infection of a hemodialysis catheter in a pediatric patient.

Hemodial Int 2019 Feb 12. Epub 2019 Feb 12.

Pediatric Nephrology division, Children's Mercy Hospital, Kansas City, Missouri, USA.

This case report discusses a pediatric patient who developed a hemodialysis catheter line infection from an uncommon etiology, Mycobacterium fortuitum. The initial presentation revealed a well appearing patient with a slow growing skin lesion near the site of the hemodialysis catheter. The treatment course was complicated by resistance to initial antibiotics leading to continued spread of the lesion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/hdi.12731DOI Listing
February 2019

Outbreak of nonfermentative Gram-negative bacteria (Ralstonia pickettii and Stenotrophomonas maltophilia) in a hemodialysis center.

Hemodial Int 2019 Feb 12. Epub 2019 Feb 12.

PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Brunei Darussalam.

We report a case series of seven patients with nonfermentative Gram-negative bacteria infections in a single dialysis center; four patients with Ralstonia pickettii and three patients with Stenotrophomonas maltophilia. Two of the seven patients were admitted to hospital for intravenous antibiotic treatment, while the rest were treated with oral antibiotics at home. Both the admitted patients had temporary vascular catheter infections from the aforementioned pathogens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/hdi.12722DOI Listing
February 2019

The renaissance of cholemic nephropathy: A likely underestimated cause of renal dysfunction in liver disease.

Hepatology 2019 Feb 11. Epub 2019 Feb 11.

Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Austria.

In this issue of Hepatology, Bräsen and Mederacke et al (1) present an analysis of all kidney biopsies performed at the gastroenterology and hepatology department at Hannover Medical School over a 16-year period. The authors identified 79 patients with both liver disease and impaired renal function, 57% of whom had acute kidney injury (AKI) or AKI overlapping chronic kidney disease (CKD), while 43% had CKD, as defined by the recently updated European clinical practice guidelines. Interestingly, 8 patients were diagnosed with cholemic nephropathy (CN), who all presented as AKI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.30558DOI Listing
February 2019
1 Read

Efficacy and Safety of Ticagrelor Compared with Clopidogrel in Patients with End-Stage Renal Disease with Acute Myocardial Infarction.

Am J Cardiovasc Drugs 2019 Feb 12. Epub 2019 Feb 12.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, 123, Ta Pei Road, Niao-Sung District, Kaohsiung, 83301, Taiwan.

Objective: This study investigated the efficacy and safety of ticagrelor compared with clopidogrel in patients with end-stage renal disease (ESRD) and acute myocardial infarction (AMI).

Methods: We retrospectively enrolled patients who had received regular dialysis and had undergone percutaneous coronary intervention (PCI) for AMI at our hospital between January 2013 and December 2016. Outcomes analyzed included cardiovascular death, death from any cause, MI, stroke, and bleeding events. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40256-018-00318-0DOI Listing
February 2019
1 Read