9,563,311 results match your criteria Diagnostic and interventional radiology Ankara Turkey[Journal]

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Clinical Challenges: Assessing Toddler Speech Sound Productions.

Authors:
Shari L DeVeney

Semin Speech Lang 2019 Mar 22;40(2):81-93. Epub 2019 Feb 22.

Department of Special Education and Communication Disorders, University of Nebraska at Omaha, Omaha, Nebraska.

When assessing toddler speech sound productions, speech-language pathologists (SLPs) must be mindful of several important but not insurmountable limitations inherent to working with this young population for whom speech sound production may be of concern. These limitations include: (1) inconsistencies in recommended connected speech sampling size and phonetic transcription accuracy, (2) the prevalence of typical intraword variability for toddlers, (3) limited information regarding the reliability of informal measures of analysis, and (4) irregularities in available normative data for referencing speech sound development and mastery. This article includes a discussion of these factors, an overview of key assessment tools for single-word and connected-speech sampling, advice for current evidence-based practice procedures, and a thorough but not exhaustive listing of opportunities to improve clinical practice in this area. Read More

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http://dx.doi.org/10.1055/s-0039-1677759DOI Listing

Accuracy of Routine Prenatal Genetic Screening in Patients Referred for Genetic Counseling.

Am J Perinatol 2019 Feb 22. Epub 2019 Feb 22.

Department of Obstetrics and Gynecology, Christiana Care Health System, Newark, Delaware.

Objective:  The American College of Obstetricians and Gynecologists (ACOG) guidelines recommend routine prenatal screening for genetic diseases that could affect the pregnancy. We sought to determine the rate of missed genetic information in the general obstetrician's routine prenatal genetic screening process.

Study Design:  This is a sequential case series of women referred for genetic counseling between March and August of 2015. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678533
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http://dx.doi.org/10.1055/s-0039-1678533DOI Listing
February 2019
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A comparison of exhaled breath online and offline measurements for diabetes pre-screening by graphene-based sensor: from powder processing to clinical monitoring prototype.

J Breath Res 2019 Feb 22. Epub 2019 Feb 22.

SRM University, Kattankulathur, Tamil Nadu, INDIA.

Several breath analysis studies have suggested a correlation between blood glucose (BG) levels and breath acetone, indicating acetone as a primary biomarker in exhaled breath for diabetes diagnosis. Herein, we have (i) fabricated and validated graphene based chemi-resistive sensors for selective and sensitive detection of acetone, (ii) performed offline breath analysis by static gas sensing setup to acquire olfactory signal and (iii) developed an LED based portable on/off binary e-nose system for pre-screening diabetes through online analysis. The fabricated sensors showed selective detection for acetone with high sensitivity (5. Read More

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http://dx.doi.org/10.1088/1752-7163/ab09aeDOI Listing
February 2019

VarGrouper - a Bioinformatic Tool for Local Haplotyping of Deletion-Insertion Variants from Next-generation Sequencing Data Post Variant Calling.

J Mol Diagn 2019 Feb 19. Epub 2019 Feb 19.

Department of Pathology, Harvard Medical School / Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Accurate genetic variant representation through nomenclature and annotation is essential for understanding functional consequence and properly noting the presence of variants across time, assays, and laboratories. Current variant calling algorithms detect single deletion-insertion variants as multiple indel and/or substitution variants from next-generation sequencing data. Consequently, these variants are separately annotated in bioinformatics pipelines, leading to inaccurate variant representation. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2018.12.003DOI Listing
February 2019

Rational "Error Elimination" Approach to Evaluating Molecular Barcoded Next-Generation Sequencing Data Identifies Low-Frequency Mutations in Hematologic Malignancies.

J Mol Diagn 2019 Feb 19. Epub 2019 Feb 19.

Hematopathology, The University of Texas MD Anderson Cancer Center, Houston; Baylor Miraca Genetics Laboratories. Electronic address:

The emergence of highly sensitive molecular diagnostic approaches such as droplet digital PCR has allowed the accurate identification of low-frequency variant alleles in clinical specimens; however, the multiplex capabilities of droplet digital PCR for variant detection are inadequate. The incorporation of molecular barcodes or unique IDs into next-generation sequencing libraries through PCR has enabled the detection of low-frequency variant alleles across multiple genomic regions. However, rational library preparation and sequencing data analytical strategies that integrate molecular barcodes have rarely been applied to clinical settings. Read More

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http://dx.doi.org/10.1016/j.jmoldx.2019.01.008DOI Listing
February 2019

Cerebral granuloma mimicking malignant neoplasm in a patient with seizures 21 years after head trauma.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurosurgery, The Affliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China. Electronic address:

Background: Chronic post-traumatic cerebral granuloma is a rare, delayed complication of traumatic brain injury. Because of its late onset of symptoms and atypical appearance, the correct diagnosis of this rare lesion is difficult.

Case Report: A 49-year-old man presented with seizures, which occured 21 years after open right forehead trauma. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.286DOI Listing
February 2019

Pediatric Intracranial Aneurysms: Favorable Outcomes despite Rareness and Complexity.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: Pediatric intracranial aneurysms (IAs) are rare and differ from their adult counterparts in terms of their aneurysmal characteristics, presentation, treatment, and outcomes. Their treatment is often more difficult and complex compared to adults. However, studies outlining the clinical impact of pediatric IAs remain sparse. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.280DOI Listing
February 2019

Diagnostic and prognostic potential of serum cell-free microRNA-214 in glioma.

World Neurosurg 2019 Feb 19. Epub 2019 Feb 19.

Department of Neurosurgery, Linyi People's Hospital, Shandong University, Linyi, Shandong Province, China. Electronic address:

Objectives: We aimed to expound feasibility of serum cell-free microRNA-214 (miR-214) as a noninvasive biomarker for glioma in this study.

Patients And Methods: We detected expression of miR-214 in medium from 2 glioma cell lines to confirm whether it is secretory in screening phase. Then we verified cell-free miR-214 expression in serum samples from an independent set of 100 preoperative glioma patients, 30 matching postoperative patients and 100 healthy controls. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.009DOI Listing
February 2019

Accuracy and usability of single-lead ECG from smartphones - A clinical study.

Indian Pacing Electrophysiol J 2019 Feb 19. Epub 2019 Feb 19.

Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Bergen, Norway.

Background: Several wireless ECG devices are commercially available for possible screening, monitoring and diagnosis of rhythms. The field is rapidly expanding, and some devices have demonstrated acceptable qualities. The objective was to evaluate the accuracy, usability and diagnostic capabilities of smartphone ECG (spECG) in both patients and healthy controls. Read More

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http://dx.doi.org/10.1016/j.ipej.2019.02.006DOI Listing
February 2019

Abdominal versus Standard Placement of the Sacral Nerve Stimulator Implantable Pulse Generator.

Urology 2019 Feb 19. Epub 2019 Feb 19.

Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL. Electronic address:

Objectives: To determine patient factors prompting anterior abdominal wall placement of the sacral nerve stimulator implantable pulse generator and investigate revision and infection rates for buttock (standard) and abdominal placement.

Methods: We retrospectively reviewed records of consecutive sacral nerve stimulation procedures by a single surgeon from 2012-2017 at a single institution.

Results: 75 patients underwent sacral nerve stimulation - 60 with standard and 15 with abdominally placed implantable pulse generators. Read More

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http://dx.doi.org/10.1016/j.urology.2019.02.013DOI Listing
February 2019

Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients.

J Hepatol 2019 Feb 19. Epub 2019 Feb 19.

Department of Pharmacology and Center for Cancer Research and Diagnostic Medicine, IBST, School of Medicine, Konkuk University, Seoul, Korea; KU Open Innovation Center, Konkuk University, Seoul, Korea; Research Institute of Medical Sciences, Konkuk University, Seoul, Korea. Electronic address:

Background & Aims: Tenofovir disoproxil fumarate (TDF) is one the most potent nucleot(s)ide analogues for treating chronic hepatitis B virus (HBV) infection. Phenotypic resistance caused by genotypic resistance to TDF has not been reported. This study aimed to characterize HBV mutations that confer tenofovir resistance. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.02.006DOI Listing
February 2019

Subcommissural organ-Reissner's fiber complex plasticity in tow animal models of copper intoxication and modulatory effect of curcumin: Involvement of serotonin.

J Chem Neuroanat 2019 Feb 19. Epub 2019 Feb 19.

Cadi Ayyad University, Faculty of sciences Semlalia, Neurosciences, Pharmacology and Environment Unit, Marrakesh, Morocco. Electronic address:

Metal neurotoxicity is a universal health preoccupation. Previous data revealed an obvious neurochemical impairment induced by metal elements as copper. This investigation was conducted to study the subcommissural organ (SCO) response to acute and subchronic Cu exposure as well as its serotoninergic innervation in Wistar rats, and the probable protective potential of curcumin in these toxicological circumstances. Read More

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http://dx.doi.org/10.1016/j.jchemneu.2019.02.004DOI Listing
February 2019

Folate receptor-beta expression as a diagnostic target in human & rodent nonalcoholic steatohepatitis.

Toxicol Appl Pharmacol 2019 Feb 19. Epub 2019 Feb 19.

University of Arizona, Department of Pharmacology and Toxicology, Tucson, AZ, USA. Electronic address:

Introduction: Nonalcoholic steatohepatitis (NASH) afflicts 20-36% of individuals with nonalcoholic fatty liver disease (NAFLD). A lipotoxic hepatic environment, altered innate immune signaling and inflammation are defining features of progression to NASH. Activated resident liver macrophages express folate receptor beta (FR-β) which may be an indicator of progression from steatosis to NASH. Read More

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http://dx.doi.org/10.1016/j.taap.2019.02.009DOI Listing
February 2019

Iron-oxide nanoparticles target intracellular HSP90 to induce tumor radio-sensitization.

Biochim Biophys Acta Gen Subj 2019 Feb 19. Epub 2019 Feb 19.

Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400085, India; Homi Bhabha National Institute, Anushakti Nagar, Mumbai 400085, India. Electronic address:

Background: Nanoparticle-based therapies have emerged as a promising approach to overcome limitations of conventional chemotherapy. Present study investigates the potential of oleic acid-functionalized iron-oxide nanoparticles (MN-OA) to enhance the radiation response of fibrosarcoma tumor and elucidates its underlying mechanism.

Methods: Various cellular and molecular assays (e. Read More

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http://dx.doi.org/10.1016/j.bbagen.2019.02.010DOI Listing
February 2019

Diagnosis and Surgical Outcomes of Facial Asymmetry According to the Occlusal Cant and Menton Deviation.

J Oral Maxillofac Surg 2019 Jan 29. Epub 2019 Jan 29.

Associate Professor, Department of Orthodontics, Institute of Craniofacial Deformity, College of Dentistry, Yonsei University, Seoul, Republic of Korea. Electronic address:

Purpose: Morphologic differences and surgical outcomes were compared between the ipsilateral type of facial asymmetry, in which the menton deviates to the side of the upward frontal occlusal plane (FOP) cant (FOP), and the contralateral type, in which the menton deviates to the side of the downward FOP cant (FOP), by using cone beam computed tomography (CBCT) images.

Materials And Methods: This retrospective study included consecutive patients with skeletal Class III malocclusion and facial asymmetry who had undergone bimaxillary orthognathic surgery and serial CBCT before, 1 month after, and 1 year after surgery. CBCT images were reconstructed and analyzed for predictor (group and timing) and outcome (CBCT measurements over time) variables. Read More

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http://dx.doi.org/10.1016/j.joms.2019.01.028DOI Listing
January 2019

Advancing the Care of Severe Asthma: Differential Diagnosis, Multidisciplinary Management, and Patient Engagement.

Am J Med 2019 Feb 19. Epub 2019 Feb 19.

Adjunct Professor, Department of Family and Community Health, University of Minnesota, Minneapolis, MN.

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http://dx.doi.org/10.1016/j.amjmed.2019.02.002DOI Listing
February 2019

The Incomplete Medicalization of Obesity: Physician Office Visits, Diagnoses, and Treatments, 1996-2014.

Public Health Rep 2019 Feb 22:33354918813102. Epub 2019 Feb 22.

2 Department of Sociology, University of Kentucky, Lexington, KY, USA.

Objectives:: Despite increased awareness of obesity-related health risks and myriad treatment options, obesity still affects more than one-third of persons in the United States and is a substantial public health problem. Studies show that physicians play a key role in obesity prevention and treatment. The objective of this study was to examine the extent to which obesity is diagnosed and treated at the level of patient-physician interaction. Read More

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http://dx.doi.org/10.1177/0033354918813102DOI Listing
February 2019

Real-world misuse, abuse, and dependence of abuse deterrent versus non-abuse-deterrent extended-release morphine in Medicaid non-cancer patients.

Postgrad Med 2019 Feb 22. Epub 2019 Feb 22.

h Pfizer Inc - Medical Affairs.

Objective: Opioids with abuse-deterrent properties may reduce widespread abuse, misuse, and diversion of these products. This study aimed to quantify misuse, abuse, dependence, and health resource use of extended-release morphine sulfate with sequestered naltrexone hydrochloride (ER-MSN; EMBEDA®), compared with non-abuse-deterrent extended-release morphine (ERM) products in Medicaid non-cancer patients.

Methods: Administrative medical and pharmacy claims data were analyzed for 10 Medicaid states from January 1, 2015, to June 30, 2016. Read More

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http://dx.doi.org/10.1080/00325481.2019.1585688DOI Listing
February 2019

Avascular osteonecrosis in kidney transplant recipients: Risk factors in a recent cohort study and evaluation of the role of secondary hyperparathyroidism.

PLoS One 2019 22;14(2):e0212931. Epub 2019 Feb 22.

Department of Rheumatology, University Hospital, Strasbourg, France.

Avascular osteonecrosis (AVN) is a bone complication that indicates poor functional prognosis. Modern immunosuppressive and steroid-sparing drugs have significantly lowered the occurrence of AVN after kidney transplantation (KT). However, recent data on its incidence rates and risk factors are lacking. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212931PLOS
February 2019

PCR with electrospray ionization-mass spectrometry on bronchoalveolar lavage for detection of invasive mold infections in hematological patients.

PLoS One 2019 22;14(2):e0212812. Epub 2019 Feb 22.

Department of Infectious Diseases, Karolinska University Hospital, Huddinge, Sweden.

Invasive mold infections are life-threatening complications in patients with hematological malignancies. Conventional microbiological methods for diagnosing invasive pulmonary mold infections have low sensitivity, and molecular methods are being developed. Detection of molds using PCR with a narrow spectrum has been reported, but data with broad-spectrum PCR are lacking. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212812PLOS
February 2019

Absence of pathogenic mutations in CD59 in chronic inflammatory demyelinating polyradiculoneuropathy.

PLoS One 2019 22;14(2):e0212647. Epub 2019 Feb 22.

Neuromuscular Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.

Objective: Mutations in CD59 cause CIDP-like polyneuropathy in children with inherited chronic hemolysis. We hypothesized that mutations in CD59 might be found in a subset of sporadic CIDP patients.

Methods: 35 patients from two centers, fulfilling the EFNS/PNS diagnostic criteria for CIDP were included. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212647PLOS
February 2019

Effects of person-centered care at the organisational-level for people with dementia. A systematic review.

PLoS One 2019 22;14(2):e0212686. Epub 2019 Feb 22.

School of Nursing, Faculty of Medicine, The University of Notre Dame Sydney, New South Wales, Australia.

The aim of the systematic review was to determine the effectiveness of organizational-level person-centered care for people living with dementia in relation to their quality of life, mood, neuropsychiatric symptoms and function. ALOIS, the Cochrane Dementia and Cognitive Improvement Group Specialised Register databases, were searched up to June 2018 using the terms dementia OR cognitive impairment OR Alzheimer AND non-pharmacological AND personhood OR person-centered care. Reviewed studies included randomized controlled trials (RCTs), cluster-randomized trials (CRTs) and quasi-experimental studies that compared outcomes of person-centered care and usual (non-person-centered) care, for people with a diagnosis of dementia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212686PLOS
February 2019

Machine learning models for early sepsis recognition in the neonatal intensive care unit using readily available electronic health record data.

PLoS One 2019 22;14(2):e0212665. Epub 2019 Feb 22.

Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.

Background: Rapid antibiotic administration is known to improve sepsis outcomes, however early diagnosis remains challenging due to complex presentation. Our objective was to develop a model using readily available electronic health record (EHR) data capable of recognizing infant sepsis at least 4 hours prior to clinical recognition.

Methods And Findings: We performed a retrospective case control study of infants hospitalized ≥48 hours in the Neonatal Intensive Care Unit (NICU) at the Children's Hospital of Philadelphia between September 2014 and November 2017 who received at least one sepsis evaluation before 12 months of age. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212665PLOS
February 2019

Performance of the BD-FACS Presto for CD4 count and hemoglobin measurement in a district hospital and rural laboratory in Ghana.

PLoS One 2019 22;14(2):e0212684. Epub 2019 Feb 22.

Earth Institute, Columbia University, New York, New York, United States of America.

Introduction: In Ghana, initiation of Antiretroviral Therapy (ART) is recommended for all patients with an HIV diagnosis, regardless of CD4+ T-cell count. However, measurement of CD4 count remains an important metric for identifying patients with advanced HIV disease, and assessing a person's overall immune status, which informs the decision to offer opportunistic infection screening and prophylaxis. Access to CD4+ T cell count in rural health facilities remains a major challenge in Ghana and other resource-limited settings. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212684PLOS
February 2019

Hybrid multivariate pattern analysis combined with extreme learning machine for Alzheimer's dementia diagnosis using multi-measure rs-fMRI spatial patterns.

PLoS One 2019 22;14(2):e0212582. Epub 2019 Feb 22.

Department of Biomedical Science and Engineering (BMSE), Institute of Integrated Technology (IIT), Gwangju Institute of Science and Technology (GIST), Gwangju, Republic of Korea.

Background: Early diagnosis of Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) is essential for timely treatment. Machine learning and multivariate pattern analysis (MVPA) for the diagnosis of brain disorders are explicitly attracting attention in the neuroimaging community. In this paper, we propose a voxel-wise discriminative framework applied to multi-measure resting-state fMRI (rs-fMRI) that integrates hybrid MVPA and extreme learning machine (ELM) for the automated discrimination of AD and MCI from the cognitive normal (CN) state. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212582PLOS
February 2019

Routine surveillance for the identification of drug resistant Tuberculosis in Tanzania: A cross-sectional study of stakeholders' perceptions.

PLoS One 2019 22;14(2):e0212421. Epub 2019 Feb 22.

Liverpool School of Tropical Medicine, Centre for Applied Health Research and Delivery, Liverpool, United Kingdom.

Background: Routine surveillance is required to monitor the performance of tuberculosis diagnostic programme and is essential for the rapid detection of drug resistance. The main objective of this study was to explore the effectiveness and stakeholder perception of the current routine surveillance system for previously treated tuberculosis cases in Tanzania with a view to identify interventions to improve and accelerate positive patient outcomes.

Methods: A study using quantitative and qualitative methods of data collection including in-depth interviews and focus group discussions with health care service providers was conducted in four regions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212421PLOS
February 2019

Genetic improvement of hip-extended scores in 3 breeds of guide dogs using estimated breeding values: Notable progress but more improvement is needed.

PLoS One 2019 22;14(2):e0212544. Epub 2019 Feb 22.

Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, United States of America.

Two hip quality phenotypes-a hip-extended score assigned by a board certified radiologist and the PennHIP distraction index-were analyzed to estimate genetic parameters and to calculate estimated breeding values used for selecting replacement breeders. Radiographs obtained at 12-18 months of age were available on 5,201 German Shepherd Dogs, 4,987 Labrador Retrievers and 2,308 Golden Retrievers. Obtained by fitting a two-trait model using Bayesian techniques, estimates of heritability for the hip-extended score were 0. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212544PLOS
February 2019

Hypermobility of joints in dancers.

PLoS One 2019 22;14(2):e0212188. Epub 2019 Feb 22.

Faculty of Medicine and Health Sciences, Jan Kochanowski University in Kielce, Kielce, Poland.

Objectives: The current understanding of hypermobility and its diagnostic criteria is still insufficient to create a complete and systematic clinical presentation of the disorder. The objective of this study was to assess the prevalence of joint hypermobility syndrome (JHS) amongst a cohort of jazz dancers, by analyzing its presence in accordance with a number of diagnostic criteria, and to verify potential risk factors for joint hypermobility in jazz dancers.

Methods: 77 jazz dancers from the Polish Dance Theater were examined (58 female and 19 male). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212188PLOS
February 2019

New endoscopic ultrasonography criteria for malignant lymphadenopathy based on inter-rater agreement.

PLoS One 2019 22;14(2):e0212427. Epub 2019 Feb 22.

Department of Gastroenterology, Aizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Japan.

Background And Aims: Various studies have been previously conducted on the diagnosis of lymphadenopathy as benign or malignant, but the results vary. These studies did not describe the inter-rater agreement on the EUS features of lymphadenopathy. In this study, we evaluate the inter-rater agreement on EUS features and propose EUS diagnostic norms for lymphadenopathy based on inter-rater agreement. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212427PLOS
February 2019

Automatic segmentation of the foveal avascular zone in ophthalmological OCT-A images.

PLoS One 2019 22;14(2):e0212364. Epub 2019 Feb 22.

Department of Computer Science, University of A Coruña, A Coruña, Spain.

Angiography by Optical Coherence Tomography (OCT-A) is a non-invasive retinal imaging modality of recent appearance that allows the visualization of the vascular structure at predefined depths based on the detection of the blood movement through the retinal vasculature. In this way, OCT-A images constitute a suitable scenario to analyze the retinal vascular properties of regions of interest as is the case of the macular area, measuring the characteristics of the foveal vascular and avascular zones. Extracted parameters of this region can be used as prognostic factors that determine if the patient suffers from certain pathologies (such as diabetic retinopathy or retinal vein occlusion, among others), indicating the associated pathological degree. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212364PLOS
February 2019

Online testing for sexually transmitted infections: A whole systems approach to predicting value.

PLoS One 2019 22;14(2):e0212420. Epub 2019 Feb 22.

School of Population Health and Environmental Sciences, King's College London, London, United Kingdom.

Background: Online testing for sexually transmitted infections has a lower unit cost than testing in clinical services and economic analysis has focused on the cost per test and cost per diagnosis in clinics and online. However, online services generate new demand for testing and shift activity between services, requiring system-level analysis to effectively predict cost-effectiveness.

Methods And Findings: Routinely collected, anonymised, retrospective data on sexual health service activity from all specialist services (clinic and online) within an inner London sexual health economy were collated and harmonised to generate a complete dataset of individual level clinic attendances. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212420PLOS
February 2019
2 Reads

Real-Time PCR based test for the early diagnosis of Haplosporidium pinnae affecting fan mussel Pinna nobilis.

PLoS One 2019 22;14(2):e0212028. Epub 2019 Feb 22.

IFAPA Agua del Pino, Cartaya, Huelva, Spain.

Noble pen shell or fan mussel, Pinna nobilis Linnaeus (1758), protected since 1992, was incorporated into the Spanish Catalogue of Threatened Species (Category: Vulnerable, Royal Decree 139/2011). The status is presently in the process of being catalogued as critically endangered, pending approval by Spanish Government (https://www.mapama. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212028PLOS
February 2019

Galactose-deficient IgA1 and the corresponding IgG autoantibodies predict IgA nephropathy progression.

PLoS One 2019 22;14(2):e0212254. Epub 2019 Feb 22.

General Teaching Hospital, 1st Faculty of Medicine, Charles University, Department of Nephrology, Prague, Czech Republic.

Background: IgA nephropathy (IgAN), the most common primary glomerulonephritis worldwide, has serious outcomes with end-stage renal disease developing in 30-50% of patients. The diagnosis requires renal biopsy. Due to its inherent risks, non-invasive approaches are needed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212254PLOS
February 2019
5 Reads

Spontaneous ilio-psoas hematomas complicating intensive care unit hospitalizations.

PLoS One 2019 22;14(2):e0211680. Epub 2019 Feb 22.

Université de Strasbourg (UNISTRA), Faculté de Médecine, Hôpitaux universitaires de Strasbourg, Service de Réanimation Médicale, Nouvel Hôpital Civil, Strasbourg, France.

Background: Ilio-psoas hematoma is a potentially lethal condition that can arise during hospital stay. However, neither the incidence nor the prognosis of patients whose stay in intensive care units (ICU) is complicated by a iatrogenic ilio-psoas hematoma is known.

Methods: A bicentric retrospective study was conducted to compile the patients who developed an ilio-psoas hematoma while they were hospitalized in ICU between January 2009 and December 2016. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211680PLOS
February 2019

Can optical spectral transmission assess ultrasound-detected synovitis in hand osteoarthritis?

PLoS One 2019 22;14(2):e0209761. Epub 2019 Feb 22.

Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

Objective: To determine whether optical spectral transmission (OST) can be used to assess synovitis in hand and wrist joints of patients with hand osteoarthritis (OA).

Design: Hand and wrist joints of 47 primary hand OA patients with at least one clinically inflamed hand or wrist joint were assessed for synovitis by OST and ultrasound (US). Associations between standardized OST and US synovitis were studied in linear mixed effects models, across all joint types together and individually for wrist, proximal interphalangeal (PIP), and distal interphalangeal (DIP) joints, and were adjusted for OA features that showed associations with US synovitis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209761PLOS
February 2019

A quantitative exploration of gastrointestinal bleeding in intensive care unit patients.

PLoS One 2019 22;14(2):e0212040. Epub 2019 Feb 22.

Department of Medicine, Columbia University Medical Center, New York, NY, United States of America.

Background: Quantitative assessments of the severity of bleeding in patients with bleeds within the gastrointestinal tract (GIB) are generally limited to blood tests like the hematocrit. The varied and irregular nature of the data collected during such observations makes it difficult in retrospective data analysis to characterize the complete course of bleeding. We intend to quantify the rate of blood loss over the course of an ICU stay, facilitating more precise analysis of retrospective data, and to use this quantification to examine questions about the effects of GIB. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212040PLOS
February 2019

Role of deformable cancer cells on wall shear stress-associated-VEGF secretion by endothelium in microvasculature.

PLoS One 2019 22;14(2):e0211418. Epub 2019 Feb 22.

Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America.

Endothelial surface layer (glycocalyx) is the major physiological regulator of tumor cell adhesion to endothelium. Cancer cells express vascular endothelial growth factor (VEGF) which increases the permeability of a microvessel wall by degrading glycocalyx. Endothelial cells lining large arteries have also been reported, in vitro and in vivo, to mediate VEGF expression significantly under exposure to high wall shear stress (WSS) > 0. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211418PLOS
February 2019

Implications of Classification of Os Trigonum: A Study Based on Computed Tomography Three-Dimensional Imaging.

Med Sci Monit 2019 Feb 22;25:1423-1428. Epub 2019 Feb 22.

Department of Orthopedic, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, China (mainland).

BACKGROUND The os trigonum is an accessory bone that is not fully fused with the talus during secondary ossification, and is one of the risk factors of posterior malleolus impact syndrome. The purpose of this study was to classify the os trigonum and to guide the diagnosis and treatment of related clinical diseases. MATERIAL AND METHODS Ankle computed tomography (CT) scans of 586 Chinese patients between October 2014 and October 2018 were reviewed. Read More

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http://dx.doi.org/10.12659/MSM.914485DOI Listing
February 2019

Culture-Proven Candida Albicans Endogenous Endophthalmitis in a Patient with Onychomycosis.

Ocul Immunol Inflamm 2019 Feb 22:1-4. Epub 2019 Feb 22.

a Department of Ophthalmology , Ankara University Faculty of Medicine , Ankara , Turkey.

Purpose: To report a case of Candida albicans endogenous endophthalmitis in an immunocompetent patient with onychomycosis.

Methods: Retrospective case report.

Results: A 40-year-old man with onychomycosis presented with C. Read More

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http://dx.doi.org/10.1080/09273948.2019.1568503DOI Listing
February 2019

Emerging Viral Infections Causing Anterior Uveitis.

Ocul Immunol Inflamm 2019 Feb 22:1-10. Epub 2019 Feb 22.

d Department of Ophthalmology , California Pacific Medical Center , San Francisco , CA , USA.

Purpose: To review the systemic and ocular manifestations of specific emergent viral infectious diseases relevant to the ophthalmologist with particular emphasis on anterior uveitis Methods: Review of literature.

Results: Arboviral diseases are among the most important emergent and resurgent human infections, occurring mostly in tropical and subtropical zones, but appearing in virtually all regions of the world as a result of climate change, travel, and globalization. Arboviral infections are transmitted to humans by the bite of hematophagous arthropods, mainly mosquitoes. Read More

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http://dx.doi.org/10.1080/09273948.2018.1562080DOI Listing
February 2019

Psychometric Properties and Factor Structure of the Center for Epidemiologic Studies Depression Scale in a National Sample of Arab Adolescents.

Issues Ment Health Nurs 2019 Feb 22:1-7. Epub 2019 Feb 22.

c Duke University School of Nursing , Durham , North Carolina , USA.

Having valid, reliable, and culturally adapted tools to screen for adolescent depression is a crucial concern for mental health care professionals who promote preventive care. To this aim, this study tested the psychometric properties and factor structure of the Center for Epidemiologic Studies Depression (CES-D) Scale among Arab adolescents. A nationally representative sample of 3,292 Jordanian adolescents aged 13-17 completed the CES-D 20-item scale. Read More

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http://dx.doi.org/10.1080/01612840.2018.1534912DOI Listing
February 2019

DNA Microarray-Based Genomic Characterization of the Pathotypes of Escherichia coli O26, O45, O103, O111, and O145 Isolated from Feces of Feedlot Cattle .

J Food Prot 2019 Feb 21:395-404. Epub 2019 Feb 21.

1 Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, Kansas 66506.

Shiga toxin-producing Escherichia coli (STEC) serogroups O26, O45, O103, O111, O121, and O145, referred to as the top six non-O157 serogroups, are responsible for more than 70% of human non-O157 STEC infections in North America. Cattle harbor non-O157 strains in the hindgut and shed them in the feces. The objective of this study was to use the U. Read More

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http://dx.doi.org/10.4315/0362-028X.JFP-18-393DOI Listing
February 2019

Reflected hemodynamic waves influence the pattern of Doppler ultrasound waveforms along the umbilical arteries.

Am J Physiol Heart Circ Physiol 2019 Feb 22. Epub 2019 Feb 22.

Hospital for Sick Children / University of TOronto, Canada.

The pulsatile pattern of blood motion measured by Doppler ultrasound within the umbilical artery is known to contain useful diagnostic information and is widely used to monitor pregnancies at risk of fetal growth restriction or stillbirth. Animal studies have identified reflected pressure waves travelling counter to the direction of blood flow as an important factor in the shape of these waveforms. In the present study, we establish a method to measure reflected waves in the human umbilical artery and assess their influence on blood velocity pulsation. Read More

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http://dx.doi.org/10.1152/ajpheart.00704.2018DOI Listing
February 2019

Correlation analysis between the SUVmax of FDG-PET/CT and clinicopathological characteristics in oral squamous cell carcinoma.

Dentomaxillofac Radiol 2019 Feb 22:20180416. Epub 2019 Feb 22.

1 Department of Radiology, 306 Hospital of PLA , Beijing , China.

Objectives:: To investigate the relationship between maximum standardized uptake value (SUVmax) of F-FDG PET/CT and clinicopathological features of oral squamous cell carcinoma (OSCC), in order to formulate a better clinical guideline.

Methods:: In 104 patients with OSCC confirmed by pathology, there were 67 males and 37 females (age, 33 - 76 years; mean age, 56 years).F-FDG PET/CT manifestations and the clinicopathological features of the 104 patients were retrospectively analyzed. Read More

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http://dx.doi.org/10.1259/dmfr.20180416DOI Listing
February 2019

Blunt cardiac injury: emergency department diagnosis and management.

Emerg Med Pract 2019 Mar 1;21(3):1-20. Epub 2019 Mar 1.

Associate Professor, Residency Program Director, SUNY Upstate Medical University, Syracuse, NY.

Blunt cardiac injury describes a range of cardiac injury patterns resulting from blunt force trauma to the chest. Due to the multitude of potential anatomical injuries blunt force trauma can cause, the clinical manifestations may range from simple ectopic beats to fulminant cardiac failure and death. Because there is no definitive, gold-standard diagnostic test for cardiac injury, the emergency clinician must utilize an enhanced index of suspicion in the clinical setting combined with an evidence-based diagnostic testing approach in order to arrive at the diagnosis. Read More

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A Review of the Dermatologic Symptoms of Idiopathic Mast Cell Activation Syndrome

J Drugs Dermatol 2019 Feb;18(2):162-168

Since the first reported cases in 2007, idiopathic mast cell activation syndrome has been increasingly recognized. Understanding of the cutaneous manifestations of this condition is imperative for dermatologists given the substantial clinical heterogeneity in its presentation and high estimated prevalence. A review of PubMed® and SCOPUS® databases was performed in order to investigate the most common dermatologic manifestations of idiopathic mast cell activation syndrome. Read More

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February 2019

Systemic Therapies for Moderate-to-Severe Atopic Dermatitis: Expert Perspectives in Practice

J Drugs Dermatol 2019 Feb;18(2):122-129

Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects around 13% of children and 7% of adults in the US. It can have a significant impact on the quality of life (QoL) of affected individuals due to pruritus and the visibility of lesions on the skin. AD is increasingly recognized as a systemic disease, since dysregulation of the adaptive and innate immune systems plays a key role in the underlying disease pathogenesis, which has important implications for how the condition is treated. Read More

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February 2019

Utility of Sry-Related HMG-Box Gene 10 (SOX10) as a marker of melanoma in effusion cytology.

Diagn Cytopathol 2019 Feb 22. Epub 2019 Feb 22.

Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.

Background: The cytodiagnosis of melanoma in effusions can be challenging. Although immunohistochemical (IHC) stains such as HMB45, Melan A, and S-100 are often utilized; the role of Sry-related HMG-box gene 10 (SOX10) in the diagnosis of melanoma in effusions has not been previously reported.

Methods: A total of 14 confirmed melanoma cases diagnosed on effusion cytology (nine pleural and five peritoneal) were collected from 2000 to 2016. Read More

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http://dx.doi.org/10.1002/dc.24162DOI Listing
February 2019

Correlation of cytopathology with flow cytometry and histopathology for the diagnosis of hematologic malignancies in young adults presenting with cervical lymphadenopathy.

Diagn Cytopathol 2019 Feb 22. Epub 2019 Feb 22.

Department of Pathology, University of Chicago, Chicago, Illinois.

Background: Fine-needle aspiration (FNA) is frequently utilized in the diagnostic workup of lymphadenopathy. We evaluated the correlation of cytopathology with flow cytometry and tissue biopsy results and assessed the prevalence of specific malignancies in young adults presenting with cervical lymphadenopathy.

Methods: Database was searched for cervical lymph node FNA performed by a cytopathologist in patients aged 18-30 years from 2005 to 2017. Read More

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http://dx.doi.org/10.1002/dc.24157DOI Listing
February 2019

Fine-needle aspiration cytology of metastatic spindle cell follicular thyroid carcinoma: A case report.

Diagn Cytopathol 2019 Feb 22. Epub 2019 Feb 22.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana.

Follicular thyroid carcinoma, spindle cell variant is extremely rare. The tumor is predominantly composed of spindle cells with a fusiform appearance that are arranged in intersecting fascicles. Fine-needle aspiration biopsy of this entity has not been previously described. Read More

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http://dx.doi.org/10.1002/dc.24159DOI Listing
February 2019
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