9,636,333 results match your criteria Diagnostic and interventional radiology Ankara Turkey[Journal]

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The Association Between Telemedicine and Emergency Department (ED) Disposition: A Stepped Wedge Design of an ED-Based Telemedicine Program in Critical Access Hospitals.

J Rural Health 2019 Apr 23. Epub 2019 Apr 23.

Department of Health Management and Policy, University of Iowa College of Public Health, Iowa City, Iowa.

Purpose: To study the relationship between the availability and activation of emergency department-based telemedicine (teleED) and patient disposition in Critical Access Hospitals (CAHs).

Methods: A non randomized stepped wedge design examined 133,396 ED visits in 15 CAHs that subscribe to a single teleED provider. Data were available for at least 12 months prior to teleED implementation and at least 12 months of post-implementation. Read More

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http://dx.doi.org/10.1111/jrh.12370DOI Listing

Swimming Upstream: Disentangling the Association between Alcohol Intake and Venous Thromboembolism.

Thromb Haemost 2019 Apr 23. Epub 2019 Apr 23.

Diagnostic Centre, University Research Clinic for Innovative Patient Pathways, Silkeborg Regional Hospital, Silkeborg, Denmark.

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http://dx.doi.org/10.1055/s-0039-1687881DOI Listing

[Nasal discharge in dogs - are microbiological and histopathological examinations clinically useful?]

Tierarztl Prax Ausg K Kleintiere Heimtiere 2019 Apr 23;47(2):84-96. Epub 2019 Apr 23.

Klinik für Kleintiere, HNO-Abteilung, Universitätstierklinikum Leipzig.

Objective: Retrospective evaluation of the diagnostic value of bacterial culture of nasal mucosal swabs and histopathologic assessment of nasal mucosal biopsies in dogs with nasal discharge.

Material And Methods: Medical records of dogs with the predominant clinical sign of nasal discharge that were referred to the ENT Unit of the Small Animal Department between January 2015 and December 2016 were reviewed.

Results: Data of 85 dogs were evaluated. Read More

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http://dx.doi.org/10.1055/a-0863-6667DOI Listing

The Role of Ancillary Techniques in Pulmonary Cytopathology.

Acta Cytol 2019 Apr 23:1-9. Epub 2019 Apr 23.

Department of Pathology, New York University School of Medicine, New York, New York, USA,

Ancillary techniques play an essential role in pulmonary cytopathology. Immunoperoxidase and special stains are by far the most common ancillary techniques used in cytopathology; however, the role of molecular diagnosis is growing, especially in the fields of pulmonary oncology and infectious disease. In this article, we review the uses of ancillary techniques in lung tumor diagnosis, lung tumor classification, predictive marker determination, primary versus metastasis differential diagnosis, and infectious organism detection. Read More

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http://dx.doi.org/10.1159/000498889DOI Listing

A scalable database of organ doses for common diagnostic fluoroscopy examinations of children: procedures of current practice at the University of Florida.

Phys Med Biol 2019 Apr 23. Epub 2019 Apr 23.

Biomedical Engineering, University of Florida, PO Box 116131, 1275 Center Drive, Gainesville, Florida, 32611-6131, UNITED STATES.

Of all the medical imaging modalities that utilize ionizing radiation, fluoroscopy proves to be the most difficult to assess values of patient organ dose owing to the dynamic and patient-specific nature of the irradiation geometry and its associated x-ray beam characteristics. With the introduction of the radiation dose structured report (RDSR) in the mid-2000s, however, computational tools have been developed to extract patient and procedure-specific data for each irradiation event of the study, and when coupled to a computational phantom of the patient, values of skin and internal organ dose may be assessed. Unfortunately, many legacy and even current diagnostic fluoroscopy units do not have RDSR reporting capabilities, thus limiting these dosimetry reporting advances. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1badDOI Listing
April 2019
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Myelopathy after zoster virus infection in immunocompetent patients: A case series.

J Spinal Cord Med 2019 Apr 23:1-5. Epub 2019 Apr 23.

a Department of Neurology , Habib Bourguiba University Hospital , Sfax , Tunisia.

Context: After primary infection, varicella zoster virus (VZV) becomes latent in ganglionic neurons. If immunity declines, VZV is reactivated and can spread to the dermatome depending from this ganglion and in some cases to the spinal cord. Myelopathy is rare and may develop in the absence of skin rash making the diagnosis very difficult. Read More

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http://dx.doi.org/10.1080/10790268.2019.1607053DOI Listing

The CSS-12: Development and Validation of a Short-Form Version of the Cyberchondria Severity Scale.

Cyberpsychol Behav Soc Netw 2019 Apr 23. Epub 2019 Apr 23.

3 School of Psychology and Psychology Research Institute, Ulster University, Londonderry, United Kingdom.

Cyberchondria is defined as an increase in anxiety about one's health status as a result of excessive online searches. McElroy and Shevlin (2014) developed the first multidimensional, self-report measure of this construct-the Cyberchondria Severity Scale (CSS). The CSS consists of 33 items which can be summed to form a total score, and/or 5 subscale scores. Read More

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http://dx.doi.org/10.1089/cyber.2018.0624DOI Listing

Long non-coding RNA XIST regulates the EGF receptor to promote TGF-β1-induced epithelial-mesenchymal transition in pancreatic cancer.

Biochem Cell Biol 2019 Apr 23. Epub 2019 Apr 23.

Yunnan Engineering Technology Center of Diagnosis and Treatment of Digestive Diseases , No.295, Xichang Road , Kunming , China , 650032 ;

Background: This study focuses on lncRNA XIST, a lncRNA involved in multiple human cancers, and aims to investigate the functional significance of XIST and the molecular mechanism underlying the EMT in PC.

Methods: Clinical specimens from 25 patients and five human bladder cancer cell lines were analyzed for XIST, YAP and microRNA(miR)-34a by qRT-PCR and Immunohistochemistry (IHC). To investigate how XIST influences the cell proliferation, invasion, apoptosis in PC, we performed the CCK-8 assay, transwell assay and flow cytometry. Read More

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http://dx.doi.org/10.1139/bcb-2018-0274DOI Listing

Adverse immune reactions and non-immune medications for perioperative use.

Rev Alerg Mex 2019 Jan-Mar;66(1):99-114

Universidad Autónoma de Nuevo León, Hospital Universitario Dr. José Eleuterio González, Centro Regional de Alergia e Inmunología Clínica, Monterrey, Nuevo León, México.

Reactions to medications can occur through a mechanism mediated by immunoglobulin or otherwise, not both. Drug allergy is a type of adverse reaction to the drug and comprises a range of hypersensitivity reactions mediated by different immunological mechanisms with diverse clinical manifestations. A rate of 3. Read More

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http://dx.doi.org/10.29262/ram.v66i1.541DOI Listing

Chronic pruritus.

Rev Alerg Mex 2019 Jan-Mar;66(1):85-98

Universidad de Antioquia, Grupo de Alergología Clínica y Experimental, Medellín, Colombia.

Chronic pruritus is defined as an unpleasant sensation on the skin that causes scratching and lasts more than six weeks. This symptom may be a manifestation of a cutaneous or systemic disease and it jeopardizes the patients' quality of life, constantly altering their sleep and daily activities. The pathophysiology is complex and it includes multiple mediators and their respective receptors which, through different signaling pathways, carry information through type C nerve fibers towards the thalamus; from where it is distributed to various areas of the cerebral cortex. Read More

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http://dx.doi.org/10.29262/ram.v66i1.345DOI Listing

Spirometry: basic concepts.

Rev Alerg Mex 2019 Jan-Mar;66(1):76-84

Benemérita Universidad Autónoma de Puebla, Hospital Universitario de Puebla, Puebla, México.

Spirometry is a pulmonary function test that allows screening, diagnosis and monitoring of respiratory diseases. This is a simple, non-invasive test that is easy to perform. By quantifying the respiratory volumes and flows, such as forced vital capacity (FVC) or forced expiratory volume in six seconds (FEV6), forced expiratory volume in the first second (FEV1), and the relationship between these parameters (FEV1/FVC or FEV1/FEV6 ratio), obstruction can be detected with high sensitivity and specificity; likewise, it is possible to classify the severity and response to the bronchodilator. Read More

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http://dx.doi.org/10.29262/ram.v66i1.536DOI Listing

[Cross-sectional survey about the prevalence of allergic rhinitis in Argentina: Study PARA].

Rev Alerg Mex 2019 Jan-Mar;66(1):55-64

Asociación Argentina de Alergia e Inmunología Clínica, Buenos Aires, Argentina.

Background: There are very few studies about the prevalence of allergic rhinitis in Argentina.

Objective: To determine the prevalence of allergic rhinitis in a population of inhabitants between the ages of 5 and 44 in Argentina.

Methods: A cross-sectional national study in which a self-reported questionnaire was used. Read More

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http://dx.doi.org/10.29262/ram.v66i1.543DOI Listing

[Diagnosis of allergic sensitization in patients with allergic rhinitis and asthma in a tropical environment].

Rev Alerg Mex 2019 Jan-Mar;66(1):44-54

Clínica El Ávila, Servicio de Alergia e Inmunología Clínica, Caracas, Venezuela.

Background: Few studies in tropical developing countries have utilized molecular diagnosis to characterize allergen-specific responses to aeroallergens.

Objective: To investigate the in vivo and in vitro responses of IgE antibodies to inhalant allergens in allergic patients with rhinitis and/or asthma.

Methods: A prospective study in which patients with allergic rhinitis and/or asthma were included. Read More

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http://dx.doi.org/10.29262/ram.v66i1.570DOI Listing

[Sensitivity and specificity of the modified epicutaneous patch test in the diagnosis of respiratory allergy to Dermatophagoides pteronyssinus].

Rev Alerg Mex 2019 Jan-Mar;66(1):38-43

Universidad Autónoma de Puebla, Hospital Universitario de Puebla, Servicio de Alergia e Inmunología Clínica, Puebla, Puebla, México.

Background: The skin prick test is recognized as the gold standard for the specific diagnosis of allergy.

Objective: To determine the sensitivity and specificity of the epicutaneous patch test that has been modified for the diagnosis of respiratory allergy to Dermatophagoides pteronyssinus.

Methods: An observational, interpretative, prolective, and transversal study. Read More

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http://dx.doi.org/10.29262/ram.v66i1.533DOI Listing

[Evaluation of diagnostic and management concepts of anaphylaxis in non-allergist physicians in Colombia].

Rev Alerg Mex 2019 Jan-Mar;66(1):18-26

Universidad de Antioquía, Grupo de Alergología Clínica y Experimental, Antioquía, Colombia.

Background: Several reports show deficiencies in the knowledge of physicians about the diagnostic criteria and the treatment of anaphylaxis, a condition that can have fatal consequences.

Objective: To evaluate the knowledge of physicians in Colombia on the fundamental aspects of anaphylaxis in diagnosis and treatment.

Methods: Analytical cross-sectional study, carried out through a survey of 11 questions that evaluate clinical aspects of anaphylaxis, addressed to general practitioners and specialists in different health areas resident in Colombia. Read More

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http://dx.doi.org/10.29262/ram.v66i1.524DOI Listing

Clinical features and prognosis of microscopic polyangiitis with usual interstitial pneumonia compared with idiopathic pulmonary fibrosis.

Clin Respir J 2019 Apr 23. Epub 2019 Apr 23.

Department of Respiratory and Critical Care Medicine, Beijing, Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing, Chao-Yang Hospital-Beijing Institute of Respiratory Medicine, Capital Medical University, No. 8 Gongren Tiyuchang South Road, Beijing, 100020, P.R. China.

Introduction: Pulmonary involvement in microscopic polyangiitis (MPA) is common, little is known about the clinical features of MPA with interstitial pneumonia (MPA-IP).

Objectives: This study aimed to explore the prevalence of microscopic polyangiitis associated usual interstitial pneumonia (UIP)(MPA-UIP) and compare its clinical features and prognosis with those of MPA-non-UIP and idiopathic pulmonary fibrosis (IPF).

Methods: A total of 73 patients with MPA-IP were identified and divided into MPA-UIP patients and MPA-non-UIP patients. Read More

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http://dx.doi.org/10.1111/crj.13032DOI Listing

Do Electronic Health Record Prompts Increase Take-Home Naloxone Administration for Emergency Department Patients After an Opioid Overdose?

Addiction 2019 Apr 23. Epub 2019 Apr 23.

Department of Emergency Medicine, University of Pittsburgh School of Medicine.

Background And Aims: Distribution of take-home-naloxone (THN) to emergency department (ED) patients who have survived an opioid overdose could reduce future opioid mortality but is not commonly performed. We examined whether electronic health record (EHR) prompts provided to ED physicians when discharging a patient after an opioid overdose could improve THN distribution.

Design: Interrupted time series analysis to compare the percentage of OD patients who received THN during the 11 months before and after implementation of an EHR prompt on June 18, 2017. Read More

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http://dx.doi.org/10.1111/add.14635DOI Listing

Drug levels and bleeding complications in atrial fibrillation patients treated with direct oral anticoagulants.

J Thromb Haemost 2019 Apr 23. Epub 2019 Apr 23.

Arianna Anticoagulazione Foundation, Bologna, Italy.

Background: Direct oral anticoagulants (DOACs) are administered at fixed dose. Aim of the study was to evaluate the relationship between DOAC C-trough or C-peak plasma levels, and bleeding complications in patients with non-valvular atrial fibrillation (NVAF).

Methods: 565 consecutive naive NVAF patients were enrolled. Read More

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http://dx.doi.org/10.1111/jth.14457DOI Listing
April 2019
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Rare cancers in childhood and adolescence in Brazil: First report of data from 19 population-based cancer registries.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

IRCCS Foundation, Evaluative Epidemiology Unit, Evaluative Epidemiology Unit, National Cancer Institute, Milan, Italy.

Background: Rare childhood cancer is challenging to define. The Italian Pediatric Rare Tumor (TREP) Study considers rare tumors to include solid malignancies characterized by an annual incidence rate of <2 cases per 1 million and not enrolled in clinical trials. The objective of the current study was to analyze the population incidence rate of rare tumors among children and adolescents (those aged birth-19 years) in Brazil. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32121
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http://dx.doi.org/10.1002/cncr.32121DOI Listing
April 2019
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Diagnostic upgrade of atypical ductal hyperplasia of the breast based on evaluation of histopathological features and calcification on core needle biopsy.

Histopathology 2019 Apr 23. Epub 2019 Apr 23.

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.

Aims: Atypical ductal hyperplasia (ADH) of breast is increasingly diagnosed in core needle biopsy (CNB). As higher grade lesions were found in the excision in a substantial proportion of ADH on CNB, factors predicting risk of subsequent upgrade are clinically significant. This study aims to investigate relevant histopathological factors in CNB that could predict diagnostic upgrade at excision. Read More

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http://dx.doi.org/10.1111/his.13881DOI Listing

Assessment of cognitive profile as a prodromal marker of the evolution of REM sleep Behavior Disorder.

Sleep 2019 Apr 23. Epub 2019 Apr 23.

Unit of Sleep Medicine and Epilepsy, IRCCS Mondino Foundation, Pavia, Italy.

Study Objectives: To search for a specific neuropsychological profile in idiopathic REM sleep Behavior Disorder (iRBD), able to predict the onset of neurodegenerative disorders.

Methods: In a longitudinal follow-up study of 63 consecutive iRBD patients (follow-up duration 6.7± 3. Read More

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http://dx.doi.org/10.1093/sleep/zsz103DOI Listing

Comparison of the microbiome, metabolome, and lipidome of obese and non-obese horses.

PLoS One 2019 23;14(4):e0215918. Epub 2019 Apr 23.

Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX, United States of America.

Metabolic diseases such as obesity and type 2 diabetes in humans have been linked to alterations in the gastrointestinal microbiota and metabolome. Knowledge of these associations has improved our understanding of the pathophysiology of these diseases and guided development of diagnostic biomarkers and therapeutic interventions. The cellular and molecular pathophysiology of equine metabolic syndrome (EMS) and obesity in horses, however, remain ill-defined. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215918PLOS

Enhanced sentinel surveillance for hepatitis B infection in 200 counties in China, 2013-2016.

PLoS One 2019 23;14(4):e0215580. Epub 2019 Apr 23.

Chinese Center for Disease Control and Prevention, Beijing,China.

Hepatitis B infection is a major public health challenge in China. Clinicians report hepatitis B cases to the National Notifiable Disease Reporting System. A 2007 study found that only 35% of hepatitis B cases that had been reported as acute infections met a rigorous case definition of acute hepatitis B, implying overreporting of new-onset infections. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215580PLOS
April 2019
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Sexually transmitted infections among HIV-infected and HIV-uninfected women in the Tapajós region, Amazon, Brazil: Self-collected vs. clinician-collected samples.

PLoS One 2019 23;14(4):e0215001. Epub 2019 Apr 23.

Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

The anogenital prevalence of sexually transmitted infections (STIs) and the use of cervico-vaginal self-collected vs. clinician-collected samples were evaluated for the diagnosis of human immunodeficiency virus (HIV)-infected and HIV-uninfected women in the Tapajós region, Amazon, Brazil. We recruited 153 women for a cross-sectional study (112 HIV-uninfected and 41 HIV-infected) who sought health services. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215001PLOS

Host-response-based gene signatures for tuberculosis diagnosis: A systematic comparison of 16 signatures.

PLoS Med 2019 Apr 23;16(4):e1002786. Epub 2019 Apr 23.

Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, United States of America.

Background: The World Health Organization (WHO) and Foundation for Innovative New Diagnostics (FIND) have published target product profiles (TPPs) calling for non-sputum-based diagnostic tests for the diagnosis of active tuberculosis (ATB) disease and for predicting the progression from latent tuberculosis infection (LTBI) to ATB. A large number of host-derived blood-based gene-expression biomarkers for diagnosis of patients with ATB have been proposed to date, but none have been implemented in clinical settings. The focus of this study is to directly compare published gene signatures for diagnosis of patients with ATB across a large, diverse list of publicly available gene expression datasets, and evaluate their performance against the WHO/FIND TPPs. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002786DOI Listing

The cost impact of PCT-guided antibiotic stewardship versus usual care for hospitalised patients with suspected sepsis or lower respiratory tract infections in the US: A health economic model analysis.

PLoS One 2019 23;14(4):e0214222. Epub 2019 Apr 23.

Panaxea B.V., Amsterdam, the Netherlands.

Background: Procalcitonin is a biomarker that supports clinical decision-making on when to initiate and discontinue antibiotic therapy. Several cost (-effectiveness) analyses have been conducted on Procalcitonin-guided antibiotic stewardship, but none mainly based on US originated data.

Objective: To compare effectiveness and costs of a Procalcitonin-algorithm versus standard care to guide antibiotic prescription for patients hospitalized with a diagnosis of suspected sepsis or lower respiratory tract infection in the US. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214222PLOS

Primary Left Atrial Angiosarcoma Presenting as Acute Coronary Syndrome.

Heart Surg Forum 2019 Apr 12;22(2):E162-E164. Epub 2019 Apr 12.

Department of Cardiovascular Diseases, University Hospital Dubrava, Avenija Gojka Šuška 6, 10 000 Zagreb, Croatia.

Primary cardiac neoplasms are extremely rare and often overlooked as differential diagnosis. Angiosarcomas are the most common primary malignant neoplasms of the heart often with nonspecific symptoms. We present a 43-year-old woman admitted to our hospital with chest pain and inferoposterolateral myocardial infarction. Read More

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https://journal.hsforum.com/index.php/HSF/article/view/2381
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http://dx.doi.org/10.1532/hsf.2381DOI Listing
April 2019
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Plasma miRNA-155 Levels Predict Atrial Fibrillation Recurrence after Cardioversion.

Heart Surg Forum 2019 Mar 11;22(2):E140-E148. Epub 2019 Mar 11.

Department of Laboratory, the First People's Hospital of Xianyang City, Xianyang, Shaanxi Province, China.

Background: MicroRNAs (miRNAs) are widely involved in the regulation of physiological processes, such as cell proliferation, differentiation, apoptosis, angiogenesis, and lipid metabolism. They might be associated with the pathological process of atrial fibrillation (AF). The purpose of our study is to investigate whether plasma miRNA-155 levels have a relationship with AF recurrence. Read More

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http://dx.doi.org/10.1532/hsf.2281DOI Listing

Unusual Drug Fever Caused by Imipenem/Cilastatin and a Review of Literature.

Heart Surg Forum 2019 Mar 8;22(2):E119-E123. Epub 2019 Mar 8.

Department of Cardiothoracic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Introduction: Drug fever is a febrile reaction caused by initiation of one drug or varieties of drugs and often disappears after cessation of the drug(s). Clinically, drug fever is frequently induced by antibiotics, anticonvulsants, and antineoplastics. There are few previous reports about drug fever caused by imipenem/cilastatin. Read More

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http://dx.doi.org/10.1532/hsf.2141DOI Listing
March 2019
1 Read

FATTY KIDNEY DISEASE: A NEW RENAL AND ENDOCRINE CLINICAL ENTITY? DESCRIBING THE ROLE OF THE KIDNEY IN OBESITY, METABOLIC SYNDROME AND TYPE 2 DIABETES.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

Both authors have no conflicts of interest for this manuscript and contributed equally to its writing.

Objective: To determine whether fatty kidney disease deserves be designated as a distinct clinical entity similar to fatty liver disease.

Methods: Analysis and interpretation of the literature in a novel conceptual framework.

Results: The kidney contributes to hyperglycemia, hypertension, inflammatory cytokines, and thus to diabetes and metabolic syndrome. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0568
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http://dx.doi.org/10.4158/EP-2018-0568DOI Listing
April 2019
1 Read

TIMING OF GH PEAK IN BOTH GLUCAGON AND CLONIDINE TESTS IS OF MAJOR CLINICAL IMPORTANCE.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

From: 11st Pediatric Department, Aristotle University, Thessaloniki, Greece.

To detect a possible correlation between timing of the peak value of GH during STs and the effectiveness of treatment with rhGH in children with idiopathic GH deficiency (iGHD). We retrospectively studied 92 patients with iGHD (57 boys, mean age at diagnosis: 9.93 years). Read More

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http://journals.aace.com/doi/10.4158/EP-2019-0089
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http://dx.doi.org/10.4158/EP-2019-0089DOI Listing
April 2019
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HEALTH-RELATED QUALITY OF LIFE IN CHILDREN AND ADOLESCENTS WITH NON-CLASSIC CONGENITAL ADRENAL HYPERPLASIA.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

From: 1 Pediatric Endocrinology and Diabetes Unit, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center.

Non-classic congenital adrenal hyperplasia (NCCAH) is a late-onset milder form of congenital adrenal hyperplasia (CAH) which differs dramatically from the classic form. Health-related quality of life (HRQOL) in pediatric patients with the sole diagnosis of NCCAH has not been determined, in this study we aimed to determine whether HRQOL is compromised in comparison to the general population. : Single-center, cross-sectional, case-control study. Read More

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http://dx.doi.org/10.4158/EP-2018-0617DOI Listing

TESTICULAR REGRESSION SYNDROME: PRACTICE VARIATION IN DIAGNOSIS AND MANAGEMENT.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

From: 1Division of Endocrinology, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA.

The purpose of this study was to assess clinical practice patterns with regard to diagnosis and management of testicular regression syndrome (TRS), a condition in 46,XY males with male-phenotypic genitalia and bilateral absence of testes. : A retrospective review was conducted at two large pediatric academic centers to examine diagnostic and management approaches for TRS. : Records of 57 patients were reviewed. Read More

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http://journals.aace.com/doi/10.4158/EP-2019-0032
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http://dx.doi.org/10.4158/EP-2019-0032DOI Listing
April 2019
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Horizontal Instability of the Acromioclavicular Joint: A Systematic Review.

Am J Sports Med 2019 Apr 23:363546519831013. Epub 2019 Apr 23.

Department of Orthopaedic Surgery, Tulane University School of Medicine, New Orleans, Louisiana, USA.

Background: Injuries to the acromioclavicular (AC) joint are common and should be suspected in patients who have shoulder pain in the region of the acromion and clavicle. Injuries to the AC ligament can cause horizontal instability and are often neglected or underdiagnosed, which can lead to poor patient outcomes.

Purpose: To perform a systematic review of the literature on the diagnosis and treatment of horizontal instability of the AC joint. Read More

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http://dx.doi.org/10.1177/0363546519831013DOI Listing
April 2019
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Orthodontic management of a complete and an incomplete maxillary canine-first premolar transposition.

Angle Orthod 2019 Apr 23. Epub 2019 Apr 23.

Maxillary canine and first premolar transposition is a complicated dental anomaly to treat, especially if the clinician's goal is to orthodontically move the canine into its normal position. Early diagnosis with cone-beam computed tomography simplifies the treatment of this pathology. This case report describes a patient with bilateral transposition, one complete and the other incomplete, involving the maxillary canine and the first premolar (Mx. Read More

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http://dx.doi.org/10.2319/080218-561.1DOI Listing

Preclinical evaluation of 68Ga-DOTA-NT-20.3: A promising PET imaging probe to discriminate human pancreatic ductal adenocarcinoma from pancreatitis.

Mol Pharm 2019 Apr 23. Epub 2019 Apr 23.

Neurotensin receptor 1 (NTSR1) is overexpressed in human pancreatic ductal adenocarcinoma (PDAC). Specific non-invasive PET imaging probes may improve diagnostic accuracy and the monitoring of therapy for patients with PDAC. Here, we report the use of the 68Ga-labeled neurotensin (NTS) analogue DOTA-NT20. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00283DOI Listing

Treatment of Psoriasis With Biologics and Apremilast in Patients With a History of Malignancy: A Retrospective Chart Review

J Drugs Dermatol 2019 Apr;18(4)

Introduction: Biologics have transformed the management of moderate-to-severe psoriasis. The risk of developing a malignancy during treatment is an important consideration, and many studies have been conducted to determine the magnitude of this risk. However, there is little research on the use of biologic treatment in psoriasis patients with a history of established malignancy. Read More

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Nucleotide Sequence Analysis of S1 Gene among Iranian Avian Infectious Bronchitis Viruses Isolated during 2001-2002.

Arch Razi Inst 2019 Mar 1;74(1):21-31. Epub 2019 Mar 1.

Department of Poultry Disease Research and Diagnosis, Razi Vaccine and Serum Research Institute, Agricultural Research, Education, and Extension Organization, Karaj, Iran.

Infectious bronchitis (IB) virus genome codes for four structural proteins, among which the S1 subunit of spike glycoprotein comprises the major epitopes to induce neutralizing antibodies. This study involved the comparison of the full S1 sequences of five IB viruses, namely two Massachusetts and three 793/B serotypes, isolated from IB outbreaks during 2001-2002, with all other Iranian and foreign 793/B isolates and 10 known serotypes. Analysis of S1 subunit showed three unique amino acid changes at positions 349 (V to L), 392 (T to N), and 393 (Q or R to T or K or S) for the Iranian 793/B isolates, compared to those of the foreign 793/B isolates reported before 2006 (onset of vaccination with 793/B vaccine in Iran). Read More

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http://archrazi.areeo.ac.ir/article_118701.html
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http://dx.doi.org/10.22092/ari.2019.123468.1254DOI Listing
March 2019
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Designing a polytopic complex vaccine candidate against Gallibacterium anatis: an In-silico study.

Arch Razi Inst 2019 Mar 1;74(1):7-20. Epub 2019 Mar 1.

R & D, Tose Kosar Group, Tehran, Iran.

The haemolytic biovar of Gallibacterium anatis (G. anatis) is responsible for urogenital, gastrointestinal, and respiratory diseases in chickens. There are numerous reports on the resistance of G. Read More

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http://dx.doi.org/10.22092/ari.2017.109804.1118DOI Listing

Clinical impact of testing for mutations and microRNAs in thyroid nodules.

Diagn Cytopathol 2019 Apr 23. Epub 2019 Apr 23.

Department of Radiology, University of Southern California, Keck School of Medicine, Los Angeles, California.

Background: We report results of a multicenter clinical experience study examining the likelihood of patients with indeterminate thyroid nodules to undergo surgery or have malignant outcome based on multiplatform combination mutation and microRNA testing (MPT).

Methods: MPT assessed mutations in BRAF, HRAS, KRAS, NRAS, and PIK3CA genes, PAX8/PPARγ, RET/PTC1, and RET/PTC3 gene rearrangements, and the expression of 10 microRNAs. Baseline clinical information at the time of MPT and clinical follow-up records were reviewed for 337 patients, of which 80% had negative MPT results. Read More

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http://dx.doi.org/10.1002/dc.24190DOI Listing

Cytology and the cell block method in diagnostic characterization of canine lymphadenopathy and in the immunophenotyping of nodal lymphoma.

Vet Comp Oncol 2019 Apr 23. Epub 2019 Apr 23.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, 55108, USA.

Minimally invasive techniques used to evaluate canine peripheral lymphadenopathy (PLN), including fine needle aspiration biopsy with cytologic evaluation (FNAB-C) and flow cytometry (FC), have benefits and limitations. The cell block (CB) method is an alternate processing technique in which fine needle aspirate biopsy samples are concentrated, fixed, and embedded in paraffin for routine histologic processing/staining. Utilizing three observers, we determined the diagnostic value of the CB in evaluating canine PLN across six categories (non-diagnostic, reactive, inflammatory/infectious, probable lymphoma, lymphoma, metastatic neoplasia) and correlated findings to immunophenotypic and clonal antigen receptor rearrangement results in canine nodal lymphoma . Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/vco.12484
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http://dx.doi.org/10.1111/vco.12484DOI Listing
April 2019
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Extended-spectrum β-lactamase in the rectal flora of patients undergoing transrectal prostate biopsy: a study of the prevalence in a major metropolitan hospital.

BJU Int 2019 Apr 23. Epub 2019 Apr 23.

Department of Urology, Royal Melbourne Hospital, Parkville, Vic., Australia.

Objectives: To determine the prevalence of extended-spectrum β-lactamase (ESBL) in patients undergoing transrectal prostate biopsy, to assess the incidence of postoperative sepsis, to correlate the development of sepsis with the presence of preoperative ESBL on rectal swabs, and to assess the adequacy of prophylactic antibiotic guidelines in the context of local ESBL prevalence.

Methods: Patients undergoing transrectal ultrasonography (TRUS)-guided biopsy at the Royal Melbourne Hospital between January 2012 and July 2016 had rectal swabs taken immediately prior to TRUS with specific cultures to identify the presence of ESBL. Patients were given a prophylactic antibiotic, 500 mg oral ciprofloxacin, 1 h before the TRUS procedure. Read More

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http://dx.doi.org/10.1111/bju.14745DOI Listing

Altered Glycemic Control Associated With Polymorphisms in the SLC22A1 (OCT1) Gene in a Mexican Population With Type 2 Diabetes Mellitus Treated With Metformin: A Cohort Study.

J Clin Pharmacol 2019 Apr 23. Epub 2019 Apr 23.

Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades "Bernardo Sepúlveda," Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.

The organic cation transporters OCT1 and OCT2 and the multidrug and toxin extrusion transporter MATE1, encoded by the SLC22A1, SLC22A2, and SLC47A1 genes, respectively, are responsible for the absorption of metformin in enterocytes, hepatocytes, and kidney cells. The aim of this study was to evaluate whether genetic variations in the SLC22A1, SLC22A2, and SLC47A1 genes could be associated with an altered response to metformin in patients with type 2 diabetes mellitus. A cohort study was conducted in 308 individuals with a diagnosis of type 2 diabetes mellitus of less than 3 years and who had metformin monotherapy. Read More

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http://dx.doi.org/10.1002/jcph.1425DOI Listing

What is your diagnosis? Swab of an eyelid swelling from a tomato frog.

Vet Clin Pathol 2019 Apr 23. Epub 2019 Apr 23.

Department of Wildlife Health Sciences, National Zoological Park/Smithsonian Conservation Biology Institute, Washington, District of Columbia.

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http://dx.doi.org/10.1111/vcp.12737DOI Listing

A randomized controlled trial of a wearable technology-based intervention for increasing moderate to vigorous physical activity and reducing sedentary behavior in breast cancer survivors: The ACTIVATE Trial.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.

Background: The benefits of an active lifestyle after a breast cancer diagnosis are well recognized, but the majority of survivors are insufficiently active. The ACTIVATE Trial examined the efficacy of an intervention (use of the Garmin Vivofit 2 activity monitor coupled with a behavioral feedback and goal-setting session and 5 telephone-delivered health coaching sessions) to increase moderate to vigorous physical activity (MVPA) and reduce sedentary behavior in breast cancer survivors.

Methods: This randomized controlled trial recruited 83 inactive, postmenopausal women diagnosed with stage I-III breast cancer who had completed primary treatment. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32143
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http://dx.doi.org/10.1002/cncr.32143DOI Listing
April 2019
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Fertility-related experiences after breast cancer diagnosis in the Sister and Two Sister Studies.

Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: Commonly used chemotherapies can be toxic to the ovaries. To the authors' knowledge, the majority of studies evaluating receipt of fertility counseling for women in their reproductive years have been performed in specific settings, thereby limiting generalizability.

Methods: A nationwide sample of US women diagnosed with breast cancer before age 45 years completed a survey assessing the prevalence of fertility counseling. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32126
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http://dx.doi.org/10.1002/cncr.32126DOI Listing
April 2019
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The Burden of Breast Cancer Predisposition Variants Across The Age Spectrum Among 10 000 Patients.

J Am Geriatr Soc 2019 Apr 23. Epub 2019 Apr 23.

Clinical Cancer Genomics, City of Hope Comprehensive Cancer Center, Duarte, California.

Background/objectives: Women diagnosed with breast cancer (BC) at an older age are less likely to undergo genetic cancer risk assessment and genetic testing since the guidelines and referrals are biased toward earlier age at diagnosis. Thus, we determined the prevalence and type of pathogenic cancer predisposition variants among women with a history of BC diagnosed at the age of 65 years or older vs younger than 65 years.

Design: Prospective registration cohort. Read More

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http://dx.doi.org/10.1111/jgs.15937DOI Listing
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