Search Our Scientific Publications & Authors

J Food Biochem 2020 Jul 2:e13353. Epub 2020 Jul 2.

College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, P.R. China.

To explore the immunoregulatory function of peony seed proteolysis product in mice, the protein from peony seed meal was extracted and hydrolyzed with bromelain. The peony seed proteolysis product was fed to mice at three different doses of 0.25, 0. Read More

J Proteomics 2020 Jun 19;225:103880. Epub 2020 Jun 19.

Institut für Medizinische Biochemie, Veterinärmedizinische Universität Wien, Veterinärplatz 1, A-1210 Wien, Austria. Electronic address:

Equine medicine represents a relevant field of veterinary science and the horse industry generates a significant economic impact. Horses can be involved in different sport disciplines, meat production, work and recreational purposes. Horses are also important for human health as they can be used as animal models for studying human diseases and in equine-assisted therapy. Read More

Contemp Oncol (Pozn) 2020 30;24(1):67-74. Epub 2020 Mar 30.

Department of Surgery and Surgical Nursing with Laboratory of Genetics and Scientific Research, Collegium Medicum, Jan Kochanowski University, Kielce General, Oncological and Endocrinological Surgery Clinic, Provincial Integrated Hospital in Kielce, Poland.

Gastric cancer (GC) is one of the most common malignant cancers worldwide. Intraperitoneal dissemination is the typical mechanism of the formation of metastases in GC. The diagnosis of the presence of intraperitoneal free cancer cells (IFCCs) is treated equally to the M (metastasis) category according to the 8 edition of the TNM classification by the American Joint Committee on Cancer. Read More

Case Rep Oncol Med 2020 9;2020:3738798. Epub 2020 May 9.

Department of Radiology, Moffitt Cancer Center, Tampa, Florida, USA.

In cancer care, tissue seeding after curative resections is a known potential complication, despite precautions taken during surgical treatment. We present an uncommon case of an abdominal wall metastasis along the tract of a surgical drain following gastrectomy for gastric adenocarcinoma. To our knowledge, this is the first case of such an occurrence in the setting of a negative staging peritoneal lavage. Read More

Int J Colorectal Dis 2020 Jun 3. Epub 2020 Jun 3.

Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Purpose: Prognosis after peritoneal metastases in colorectal cancer is worse than that after lung or liver metastases. Previously, we demonstrated the safety of intraperitoneal (ip) administration of paclitaxel (PTX) combined with mFOLFOX6/CapeOX plus bevacizumab for colorectal cancer with peritoneal metastasis in a phase-I trial. Here, we evaluated the efficacy of this chemotherapy. Read More

Obes Surg 2020 May 27. Epub 2020 May 27.

Department of Bariatric Surgery, CHU Felix-Guyon, St-Denis, la Réunion, France.

Background: Recently, improvised variants of sleeve gastrectomy SG were reported as alternative bariatric options in patients suffering from both morbid obesity and GERD, including mainly additional anterior or posterior fundoplication over a partially sleeved stomach.

Methods: We present the case of a 29-year-old male patient with a body mass index (BMI) of 46.2 kg/m2 underwent laparoscopic SG with concomitant posterior fundoplication: Nissen-SG (N-SG). Read More

Shock 2020 May 18. Epub 2020 May 18.

Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI.

Regulatory guidelines mandate housing for laboratory mice at temperatures below their thermoneutral zone, creating chronic cold stress. However, increases in housing temperature could alter immune responses. We hypothesized housing mice at temperatures within their thermoneutral zone would improve sepsis survival and alter immune responses. Read More

Biomed Pharmacother 2020 Jul 8;127:110169. Epub 2020 May 8.

Department of Anesthesiology, The Affiliated Hospital of Yan'an University, Yan'an, 716000, Shaanxi Province, PR China.

Volatile anesthetics have been proven to treat experimental sepsis. Sevoflurane combined with oxygen is widely applied in the clinic, and our previous study indicated that this regimen significantly reduced sepsis-induced inflammatory responses and that inhibition of NF-κB pathway activation may contribute to this protection effect. Furthermore, our previous data has shown that sevoflurane combined with oxygen has prevention effect on sepsis-induced lung injury properties and bactericidal properties, but the mechanism is not well understood. Read More

BMC Surg 2020 May 12;20(1):98. Epub 2020 May 12.

Department of Surgery, Centro Hospitalar Universitário do Algarve - Unidade de Portimão, Portimão, Portugal.

Background: This study describes the successful treatment of two clinical settings of grade V pancreaticoduodenal blunt trauma only possible due to the prompt collaboration of a peripheral trauma hospital and a central hepatobiliary and pancreatic unit.

Case Presentation: We reviewed the clinical records of two male patients aged 17 and 47 years old who underwent a two-stage pancreaticoduodenectomy after a previous Damage-Control Surgery (DCS). Both patients were transferred to our Hepatobiliopancreatic Unit 2 days after immediate DCS with haemostasis, debridement, duodenostomy, gastroenterostomy, external drainage and laparostomy. Read More

Am Surg 2020 Apr;86(4):346-353

From the *Department of Surgery, Jinling Hospital, Nanjing Medical University, Nanjing, P R China and.

Enterocutaneous fistulas (ECFs) requiring admission to ICU is a serious surgical complication. A growing number of patients survive ECFs but remain chronically critically ill. The aim of our study was to investigate the risk factors of hospital death in patients with chronic critical illness attributed to ECFs. Read More

Langenbecks Arch Surg 2020 May 9;405(3):353-355. Epub 2020 May 9.

Department of Surgery, Sengkang General Hospital, 110 Sengkang East Way, Singapore, 544886, Singapore.

Purpose: COVID-19 greatly affected millions and affected the way we practice with heightened posture in the way we treat surgical patients. Surgical consensus guidelines are recommending caution in the use of laparoscopy for the theoretical possibility of viral transmission from aerosolization of tissue and peritoneal fluid during surgery. However, there has yet to be proof of COVID-19 being present in peritoneal fluid, justifying the consensus statements. Read More

Int J Surg Case Rep 2020 22;70:20-23. Epub 2020 Apr 22.

Department of Artificial Organs, Akane-Foundation, Tsuchiya General Hospital, Japan.

Introduction: Perforative peritonitis in patients on peritoneal dialysis (PD) is a serious adverse event associated with significant mortality. The signs and symptoms of perforative peritonitis in patients on PD are often confused with those of PD-related peritonitis; therefore, early diagnosis is often difficult.

Presentation Of Cases: In all three cases, antibiotic therapy was started for peritonitis. Read More

Surg Case Rep 2020 May 1;6(1):88. Epub 2020 May 1.

Division of Gastrointestinal and Pediatric Surgery, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, Tottori, 683-8504, Japan.

Background: Despite recent advances in systemic chemotherapy, the prognosis of patients with peritoneal metastases from gastric cancer still remains poor. Nonetheless, several efficacious intraperitoneal chemotherapy regimens have recently been developed for patients with peritoneal metastases. However, no study has investigated the effectiveness of intraperitoneal chemotherapy for metachronous peritoneal metastases from gastric cancer after curative surgery. Read More

Endosc Int Open 2020 May 17;8(5):E573-E577. Epub 2020 Apr 17.

Université Libre de Bruxelles, Campus Erasme, Gastroenterology, Brussels, Belgium.

 Lateral duodenal wall perforation by a migrated stent is a potential complication of biliary stenting. By systematic database revision, we identified a series of six patients with lateral duodenal wall perforation caused by a displaced plastic biliary stent that were treated with over-the-scope clip (OTSC) between January 1, 2014 and March 31, 2019. In this series, most cases were related to stenting of benign strictures with single or double stenting and with the use of stents longer than 12 cm. Read More

Zhonghua Shao Shang Za Zhi 2020 Apr;36(4):288-296

Department of Burns and Plastic Surgery, the Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China.

To explore the influence of human amniotic mesenchymal stem cells (hAMSCs) on the in vivo and in vitro regulation of macrophage phenotypes and inflammatory factors associated with wound healing of full-thickness skin wounds in mice. Fresh amniotic membrane discarded from full-term delivery by 5 healthy pregnant women in the Department of Obstetrics and Gynecology of the Affiliated Hospital of Zunyi Medical University was used for the isolation and culture of hAMSCs by enzyme digestion method. The third passage of cells was used for identification of adipogenic and osteogenic differentiation. Read More

Oncol Rep 2020 Apr 17;43(4):1081-1088. Epub 2020 Feb 17.

Center for Clinical Research, Jichi Medical University, Shimotsuke, Tochigi 329‑0498, Japan.

The peritoneal surface is the most frequent site of metastasis disease in patients with gastric cancer. Even after curative surgery and adjuvant chemotherapy, peritoneal recurrences often develop. Exosomes play pivotal roles in tumor metastasis via the transfer of microRNAs (miRNAs). Read More

Case Rep Oncol 2020 Jan-Apr;13(1):225-232. Epub 2020 Mar 19.

Department of Surgery, Tokyo Dental College Ichikawa General Hospital, Ichikawa, Japan.

We report the case of a 65-year-old male who developed heterochronous local recurrences of gastric cancer in the jejunal pouch (J-pouch) four times after total gastrectomy. He underwent total gastrectomy, J-pouch, and Roux-en-Y reconstruction for stage II gastric cancer in 2005. Four local recurrences appeared on the esophago-jejunal anastomosis, the suture line within the pouch, the esophago-jejunal anastomosis, and the anastomosis between the jejunum and Y-loop, which were resected by partial excision or endoscopic submucosal dissection. Read More

Mol Immunol 2020 Apr 16;122:80-88. Epub 2020 Apr 16.

Department of Hematology and Key Laboratory of Non-Resolving Inflammation and Cancer of Human Province, The 3rd Xiangya Hospital, Central South University, Changsha, Hunan Province, 410000, PR China; Key Laboratory of Medical Genetics, School of Biological Science and Technology, Central South University, Changsha, Hunan Province, 410000, PR China. Electronic address:

Background: The NOD-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasomes are intracellular protein complexes that orchestrate immune responses through mediating caspase-1 activation, which leads to maturation of pro-interleukin (IL)-1β. Though it is known that both Gram-negative and Gram-positive bacteria could activate the NLRP3 inflammasome, the roles of NLRP3 inflammasome in bacterial sepsis is ill-defined.

Methods: Sepsis was induced in C57BL/6, Nlrp3 KO, Asc KO and interleukin-1-receptor (Il1r) KO male mice. Read More

J Surg Res 2020 Aug 13;252:231-239. Epub 2020 Apr 13.

Department of Gastroenterological and Pediatric Surgery, Oita University Faculty of Medicine, Oita, Japan.

Background: Standard treatment for diffuse peritonitis due to colorectal perforation may be insufficient to suppress inflammatory reaction in sepsis. Thus, developing new treatments is important. This study aimed to examine whether intraperitoneal irradiation by artificial sunlight suppresses inflammatory reaction in a lipopolysaccharide (LPS)-induced peritonitis model after surgical treatments. Read More

Zhonghua Yi Xue Za Zhi 2020 Apr;100(13):1033-1037

Department of Critical Care Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

To observe the effects of 2-aminopurine (2-AP), a double-stranded RNA-dependent protein kinase (PKR) inhibitor, on organ function, plasma inflammatory factor expression and 7 days mortality in sepsis mice induced by cecal ligation puncture (CLP). Forty specific specific pathogen free C57BL/6 mice were randomly divided into sham group (10), CLP group (10), CLP+2-AP group (10) and 2-AP group (10). CLP was used to establish sepsis mice models. Read More

Dig Endosc 2020 Apr 10. Epub 2020 Apr 10.

Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.

Objectives: Transrectal laparoscopy (TRLS) using a flexible endoscope was recently proposed for peritoneal observation. Although previous studies have reported its feasibility, follow-up durations were insufficient to ascertain technical safety. Moreover, knowledge about the technical feasibility of collecting peritoneal cytological lavage or ascites during TRLS is limited. Read More

GE Port J Gastroenterol 2020 Feb 5;27(2):124-127. Epub 2019 Sep 5.

General Surgery Unit, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Background: Hemorrhagic rupture of a hepatic cyst is rare. To date, very few cases have been reported in the literature.

Case Report: A patient with a history of a suspected liver hydatid cyst presented to the emergency department with abdominal pain and fever. Read More

Eur J Pharmacol 2020 Jun 1;877:173095. Epub 2020 Apr 1.

Department of Pharmacology, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brazil. Electronic address:

Previous studies have shown that phagocytosis of apoptotic cells can tune the macrophage phenotype and trigger the resolution of inflammation. This mechanism is largely dependent on the recognition of phosphatidylserine (PS) residues on the outer membrane of dying cells. Therefore, we sought to assess the effects of PS-containing liposomes (mimics of apoptotic cells) on the leukocyte migration profile during the inflammatory process in vivo. Read More

Sci Rep 2020 Apr 1;10(1):5748. Epub 2020 Apr 1.

Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Chapman University, Irvine, CA, USA.

Gout is a chronic arthritis caused by the deposition of poorly soluble monosodium urate monohydrate (MSU) crystals in peripheral joints. Resident macrophages initiate inflammation in response to MSU mediated by NF-κB nuclear translocation and NLRP3 inflammasome activation. We investigated the role of CD44, a transmembrane receptor, in mediating MSU phagocytosis by macrophages. Read More

Surg Res Pract 2020 12;2020:5738236. Epub 2020 Mar 12.

Departamento Básico, Universidade Federal de Juiz de Fora (UFJF), Campus Governador Valadares, Governador Valadares, MG, Brazil.

. An exacerbated reaction to peritoneal infection and attendant surgical procedures is characterized by an intense hyperinflammatory state, the magnitude of which is proportional to the severity of tissue injury. Laparoscopy generates lower levels of tissue damage compared with open surgery and should induce less pronounced immune responses. Read More

World J Gastrointest Endosc 2020 Mar;12(3):111-118

Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.

Background: The healthcare impact of obesity is enormous, and there have been calls for new approaches to containing the epidemic worldwide. Minimally invasive procedures have become more popular, with one of the most widely used being endoscopic sleeve gastroplasty (ESG). Although major adverse events after ESG are rare, some can cause considerable mortality. Read More

Int J Mol Sci 2020 Mar 18;21(6). Epub 2020 Mar 18.

Laboratório de Patogenicidade Microbiana, Universidade Ceuma, São Luís 65075-120, Brazil.

is an important pathogen responsible for a variety of diseases. We have recently shown that Pic, a serine protease secreted by , mediates immune evasion by the direct cleavage of complement molecules. The aim of this study was to investigate the action of a Pic-producing bacteria in a murine model of sepsis. Read More

Gan To Kagaku Ryoho 2019 Dec;46(13):2565-2567

Dept. of Surgery, Suita Municipal Hospital.

A 28-year-oldwoman visiteda clinic with a complaint of epigastralgia 3 months after delivery. She was diagnosedwith gastritis andtreatedwith medication. Two months later, in January 2006, she was admittedto our hospital with a complaint of dysphagia. Read More

J Lipid Res 2020 Jun 10;61(6):896-910. Epub 2020 Mar 10.

Department of Molecular Biology, University of Duisburg-Essen, 45147 Essen, Germany

Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases. Specific ASM inhibitors are currently not sufficiently characterized. Here, we found that 1-aminodecylidene bis-phosphonic acid (ARC39) specifically and efficiently (>90%) inhibits both lysosomal and secretory ASM in vitro. Read More

Wounds 2020 Jan 23. Epub 2020 Jan 23.

University of North Texas, Denton, TX.

Introduction: Management of the open abdomen (OA) has rapidly evolved over the last several decades due to the improved understanding of the underlying pathophysiology of patients with an OA, adoption of damage control surgery, and the use of temporary abdominal closure (TAC) techniques for this patient population. The TAC utilizing negative pressure has been successful for managing patients with an OA with improved time to closure. Recent studies have started to examine the use of TAC in conjunction with negative pressure wound therapy with instillation and dwell time (NPWTi-d) for the management of the OA. Read More

World J Surg 2020 Jul;44(7):2185-2190

Department of Visceral, Minimally Invasive and Oncologic Surgery, Marien Hospital Düsseldorf, Rochusstr. 2, 40479, Düsseldorf, Germany.

Background: Secondary peritonitis is associated with high rates of morbidity and mortality. Data on the effect of staged re-laparotomy or re-laparoscopy as a surgical option in the management of abdominal sepsis due to secondary peritonitis are limited and conflicting. Herein, we report the outcomes of patients undergoing staged peritoneal lavage (SPL) for secondary peritonitis in our department. Read More

Sci Rep 2020 Mar 5;10(1):4139. Epub 2020 Mar 5.

Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan.

A multispecies outbreak of IMP-6 carbapenemase-producing Enterobacterales (IMP-6-CPE) occurred at an acute care hospital in Japan. This study was conducted to understand the mechanisms of IMP-6-CPE transmission by pulsed-field gel electrophoresis (PFGE), multilocus sequence typing and whole-genome sequencing (WGS), and identify risk factors for IMP-6-CPE acquisition in patients who underwent abdominal surgery. Between July 2013 and March 2014, 22 hospitalized patients infected or colonized with IMP-6-CPE (Escherichia coli [n = 8], Klebsiella oxytoca [n = 5], Enterobacter cloacae [n = 5], Klebsiella pneumoniae [n = 3] and Klebsiella aerogenes [n = 1]) were identified. Read More

Planta Med 2020 Apr 25;86(6):405-414. Epub 2020 Feb 25.

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.

Postoperative adhesions are regarded as the major complication following abdominal surgery. has shown antioxidative and anti-inflammatory effects. Therefore, we aimed to assess the influence of 70% v/v hydro-ethanolic extract of the aerial parts of against postoperative abdominal adhesions in a rat model. Read More

Cancer Med 2020 Apr 24;9(8):2879-2890. Epub 2020 Feb 24.

Department of Pathology, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.

Background: Pre-resection pleural lavage cytology is useful to predict tumor recurrence and the prognosis of lung cancer patients. Recently, extracellular vesicles (EVs) isolated from effusion specimens have come under the spotlight, and several studies showed that microRNA in EVs is associated with prognosis. MicroRNA-21 (miR-21) is a representative onco-microRNA, and miR-21 in EVs (EV-miR-21) promotes cancer dissemination by inducing mesothelial to mesenchymal transition (MMT) in the peritoneal cavity. Read More

N Z Med J 2020 02 21;133(1510):88-90. Epub 2020 Feb 21.

Consultant General Surgeon, Head of General Surgery, Taranaki Base Hospital, New Plymouth.

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Feb;23(2):170-176

The Third Department of Surgery, The Fourth Hospital, Hebei Medical University, Shijiazhuang 050017, China.

To explore the clinical significance of laparoscopic exploration combined with abdominal exfoliative cytology in the diagnosis and treatment of patients with locally advanced gastric cancer. Inclusion criteria: (1) cancer confirmed by gastroscopy and pathology without preoperative anti-tumor treatment; (2) no distant metastases found in preoperative imaging examinations; (3) patients without surgical contraindications and being tolerant to surgery; (4) patients were willing to undergo laparoscopic exploration and abdominal exfoliative cytology examination, and signed informed consent. A retrospective cohort study method was used to collect and analyze the clinicopathological data of 225 patients with advanced gastric cancer based on the above inclusion criteria from a prospective, multicenter, open, randomized controlled phase III clinical trial (registration No. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Feb;23(2):115-122

Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai 200025, China.

Perioperative whole-process management (WPM) for patients with advanced gastric cancer (AGC) mainly focuses on some clinical issues which are easily neglected or underappreciated. WPM is helpful in making a scientific and rational therapeutic plan, and avoiding inadequate communication in multi-disciplinary participation, so that the diagnosis, treatment and rehabilitation for AGC patients can be integrated organically. Based on the current clinical practice for AGC patients, eight key issues in WPM should be emphasized. Read More

Rev Col Bras Cir 2020 31;46(6):e20192314. Epub 2020 Jan 31.

Hospital de Clínicas de Passo Fundo, Serviço de Cirurgia do Aparelho Digestivo, Passo Fundo, RS, Brasil.

Objective: to assess whether laparoscopy with peritoneal lavage is superior to computed tomography for staging gastric adenocarcinoma and whether it can modify the surgical approach.

Methods: we conducted a retrospective study of 46 patients with gastric adenocarcinoma treated by the digestive surgery team of the Passo Fundo Clinics Hospital (RS), from January 2015 to December 2018, and submitted to laparoscopy with preoperative peritoneal lavage. All patients underwent preoperative clinical staging with computed tomography. Read More

Shock 2020 Jan 20. Epub 2020 Jan 20.

Department of Anesthesiology, University of California, San Francisco, San Francisco, California.

Intra-abdominal infection is the second most common cause of sepsis, and the mortality rate from abdominal sepsis remains high. High molecular weight (HMW) hyaluronic acid (HA) has been studied in sterile injury models as an anti-inflammatory and anti-permeability agent. This study evaluated the therapeutic effects of intraperitoneal HMW HA administration in mice with peritonitis-induced sepsis. Read More

Ann Surg 2020 Jan 14. Epub 2020 Jan 14.

Department of Internal Medicine and Surgery, (DIMEC) Alma Mater Studiorum, University of Bologna, S.Orsola-Malpighi Hospital, Italy.

Objective: To evaluate all invasive treatments for suspected IPN.

Summary Of Background Data: The optimal invasive treatment for suspected IPN remains unclear.

Methods: A systematic search of randomized clinical trials comparing at least 2 invasive strategies for the treatment of suspected IPN was carried out. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2020 Jan;23(1):87-91

Department of Gastrointestinal Oncology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China.

Comprehensive treatment of gastric cancer is mainly based on the pathological staging. The T stage mainly depends on the accurate determination of the depth of the tumor invasion. The accurate T stage should be standardized pathological examination and continuous sectioning. Read More

Int J Cancer 2020 Jul 17;147(1):277-284. Epub 2020 Feb 17.

Department of Pathology, Hospital Universitari Arnau de Vilanova, IRBLLEIDA, Lleida, Spain.

Endometrial cancer (EC) is the most common gynecologic malignancy in developed countries. Although most patients are diagnosed at early stages, 15-20% will relapse despite local treatment. Presently, there are no reliable markers to identify patients with worse outcomes who may benefit from adjuvant treatments, such as chemotherapy, and liquid biopsies may be of use in this setting. Read More

J Cytol 2020 Jan-Mar;37(1):40-45. Epub 2019 Dec 23.

Department of Surgical Gastroenterology, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark.

Context: The utility of peritoneal washing cytology in patients with gastroesophageal junction cancer has not been thoroughly evaluated.

Aims: The study aimed to determine the incidence of free peritoneal tumor cells by peritoneal washing cytology before and after neoadjuvant chemotherapy using conventional cytopathological methods and immunohistochemical staining for the analysis of peritoneal washings.

Settings And Design: A prospective study conducted at a single tertiary referral hospital. Read More

J Gastrointestin Liver Dis 2019 Dec 19;28(suppl. 4):29-34. Epub 2019 Dec 19.

Department of Colorectal Surgery, King's College Hospital, London, United Kingdom.

In this session different issues for the surgical management of diverticular disease DD) were considered. The first session debated about the antibiotic treatment for acute uncomplicated diverticulitis (AUD), and supports their use selectively rather than routinely in patients with AUD. The second session discussed the best surgical treatment for those patients. Read More

Am Surg 2019 Dec;85(12):1318-1326

From the *Discipline of Trauma Surgery, Department of Surgery, University of São Paulo Medical School, São Paulo, Brazil.

The practical component of the Advanced Trauma Life Support (ATLS®) course typically includes a TraumaMan® manikin. This manikin is expensive; hence, a low-cost alternative (SurgeMan®) was developed in Brazil. Our primary objective was to compare user satisfaction among SurgeMan, TraumaMan, and porcine models during the course. Read More

Anticancer Res 2020 Jan;40(1):405-412

Department of Surgery, Yokohama City University, Yokohama, Japan.

Background/aim: To evaluate the outcomes of curative resection for Borrmann type IV gastric cancer through an analysis of the clinical, surgical and pathological data and through identifying which of these prognostic factors are associated with survival.

Patients And Methods: We retrospectively analyzed 2798 patients who had undergone excision of the primary lesion and 122 patients with type IV gastric cancer undergoing curative resection (R0 or 1) at Yokohama City University Hospital and Kanagawa Cancer Center between November 1995 and May 2016.

Results: Borrmann type IV gastric cancer had more advanced and unfavorable clinicopathological factors compared to other types. Read More

Eur J Pharmacol 2020 Feb 27;869:172893. Epub 2019 Dec 27.

Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, 201203, China. Electronic address:

Organosulfur compounds, such as L-cysteine, allicin and other sulfur-containing organic compounds in Allium species, have been proposed to possess many important physiological and pharmacological functions. A novel L-cysteine derivative, t-Butyl S-allylthio-L-cysteinate (5P39), was designed and synthesized by combining L-cysteine derivative and allicin pharmacophore through a disulfide bond. This study aimed to explore the effects and mechanisms of 5P39 on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. Read More

J Ethnopharmacol 2020 Mar 23;250:112499. Epub 2019 Dec 23.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100193, China. Electronic address:

Ethnopharmacological Relevance: Elephantopus scaber Linn. (E.scaber) is a widely-used traditional herb whose use has been documented for various inflammatory diseases such as fever, sore throat, dysentery, carbuncle and so on. Read More

J Immunol Res 2019 4;2019:3105817. Epub 2019 Dec 4.

Department of Immunology, Biomedical Science Institute, University of São Paulo (USP), 1730 Professor Lineu Prestes Avenue, 05508-900 São Paulo, Brazil.

The severity of malaria is associated with parasite cytoadherence, but there is limited knowledge about the effect of parasite cytoadherence in malaria-associated acute respiratory distress syndrome (ARDS). Our objective was to evaluate the cytoadherence of infected red blood cells (iRBCs) in a murine model of ARDS and to appraise a potential function of endothelial protein C receptor (EPCR) in ARDS pathogenesis. DBA/2 mice infected with ANKA were classified as ARDS- or hyperparasitemia- (HP-) developing mice according to respiratory parameters and parasitemia. Read More

Br J Surg 2020 Jan;107(1):120