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Cell Physiol Biochem 2019 ;52(3):565-579

Division of Research, Department of Surgery, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.

Background/aims: During sepsis, an unchecked pro-inflammatory response can be detrimental to the host. We investigated the potential protective effect of amitriptyline (AT).

Methods: We used two murine models of sepsis: Cecal ligation and puncture and endotoxemia following LPS challenge. Read More

Indian J Surg Oncol 2019 Feb 19;10(Suppl 1):3-11. Epub 2019 Feb 19.

5Department of Surgery, Kanazawa University Hospital, Kanazawa University, Kanazawa, Japan.

In this review, Japanese experience of cytoreductive surgery and perioperative chemotherapy is described. The new concept of peritoneal metastasis (PM) type, i.e. Read More

Inflammation 2019 Mar 15. Epub 2019 Mar 15.

Department of Cardiology and Angiology I, Heart Center Freiburg University, Faculty of Medicine, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg im Breisgau, Germany.

Leukocyte transmigration through the blood vessel wall is a fundamental step of the inflammatory response and requires expression of adhesion molecule PECAM-1. Accumulating evidence implicates that semaphorin (Sema) 3F and its receptor neuropilin (NRP) 2 are central regulators in vascular biology. Herein, we assess the role of Sema3F in leukocyte migration in vitro and in vivo. Read More

Int J Surg Case Rep 2019 5;56:107-109. Epub 2019 Mar 5.

Department of General Surgery, Moruya District Hospital, 2 River Street, Moruya, NSW, 2537, Australia.

Introduction: Gallstone spillage during laparoscopic cholecystectomy is a common occurrence. Complications due to spilled gallstones occur in up to 5% of laparoscopic cholecystectomy cases, with complications having been reported up to 20 years after laparoscopic cholecystectomy.

Case Report: We report the case of a 70 year old male who presented for elective right inguinal hernia repair. Read More

Mol Med Rep 2019 Mar 12. Epub 2019 Mar 12.

Department of Anesthesiology, National Cancer Center/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, Guangdong 518116, P.R. China.

The cholinergic anti‑inflammatory pathway is considered an attractive approach for the alleviation of inflammatory diseases. Sepsis is characterized by systemic inflammation and widespread organ injury, especially that in the lung. In the present study, we explored the effects of an α7nAChR agonist, PNU‑282987, on sepsis‑induced lung injury and investigated the mechanisms of PNU‑282987 in response to lipopolysaccharide (LPS) stimulation in peritoneal macrophages. Read More

Diagn Cytopathol 2019 Mar 1. Epub 2019 Mar 1.

Pathology Unit, University Hospital Campus Bio-Medico, Rome, Italy.

Background: Intraperitoneal malignant cells detection in patients with gastric cancer is associated with a significant decrease in overall survival. The overall accuracy of cytological examination of peritoneal lavages, however, is quite low, and intraperitoneal recurrence has been observed even in patients with negative cytology. Immunocytochemistry and molecular techniques have been investigated to improve high-risk patients' identification with variable results. Read More

Methods Mol Biol 2019 ;1960:237-247

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA.

Toxoplasma gondii is an intracellular, apicomplexan parasite of great importance in both human and animal health. Current research has identified a variety of important and necessary factors specific to the parasite that enable it to infect and persist in a wide array of mammalian hosts. However, in order to continue to build our understanding of T. Read More

Trauma Surg Acute Care Open 2019 24;4(1):e000207. Epub 2019 Jan 24.

Division of Trauma, Critical Care and Acute Care Surgery, Department of Surgery, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA.

Background: The ability of focused assessment with sonography for trauma (FAST) to detect clinically significant hemorrhage in hypotensive injured patients remains unclear. We sought to describe the sensitivity and specificity of FAST using findings at laparotomy as the confirmatory test.

Methods: Patients from the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study that had a systolic blood pressure < 90mm Hg and underwent FAST were analysed. Read More

Ann Med Surg (Lond) 2019 Mar 30;39:10-15. Epub 2019 Jan 30.

Department of Surgery, Jichi Medical University, Tochigi, Japan.

Background And Objectives: Peritoneal dissemination of gastric cancer is often associated with serosal infiltration. The aim of this study was to evaluate the clinical importance of peritoneal lavage cytology in patients with gastric carcinoma without serosal invasion. The incidence and impact on prognosis of positive cytology were analyzed. Read More

J Med Case Rep 2019 Feb 22;13(1):42. Epub 2019 Feb 22.

Department of Surgery, Osaka Red Cross Hospital, 5-30 Fudegasakicho, Tennoji Ward, Osaka, 543-8555, Japan.

Background: The prognosis of stage IV gastric cancer and human epidermal growth factor 2 (HER2)-positive gastric cancer is poor, although new drugs and regimens have been developed. We report a case of a patient with stage IV HER2-positive gastric cancer treated successfully by conversion therapy and trastuzumab.

Case Presentation: The patient was a 73-year-old Japanese man diagnosed as L, type 3, circ, T4aNxCy1P1M1, stage IV (the Japanese classification of gastric carcinoma). Read More

Pancreas 2019 Mar;48(3):343-349

From the Department of Gastroenterology, First Affiliated Hospital of Nanchang University, Nanchang, China.

Objectives: This study aimed to compare the efficacy of percutaneous drainage (PCD) versus peritoneal lavage (PL) for the treatment for severe acute pancreatitis patients with pancreatic ascites (PAs).

Methods: Severe acute pancreatitis patients with PAs were randomly assigned within 3 days of onset of symptoms to receive either PL or PCD. The primary end point was a composite of mortality or major complications during hospitalization and within 1 month of discharge. Read More

Saudi J Med Med Sci 2018 May-Aug;6(2):112-114. Epub 2018 Apr 16.

Department of Internal Medicine, College of Medicine, King Khalid University, Abha, Saudi Arabia.

This report describes the endoscopic treatment of a biliary leak following a gunshot injury in a young Saudi female. She was admitted to the emergency unit having sustained an accidental gunshot on the upper part of her right shoulder when her spouse was maintaining his gun sitting on a higher level chair. She was intubated and immediately taken for exploratory laparotomy, which revealed right liver lobe laceration and significant hemoperitoneum. Read More

Rozhl Chir 2019 ;98(1):18-22

Introduction: Diffuse peritonitis is a serious disease with rather poor therapeutic results. Management traditionally consists in the surgical treatment of its etiology, combined with targeted antibiotic therapy and complex intensive care of the patient. The basic procedure includes the identification and treatment of the origin of peritonitis, followed by thorough abdominal cavity toilet, lavage and drainage. Read More

Colorectal Dis 2019 Feb 16. Epub 2019 Feb 16.

Department of Surgery, Amsterdam Universitair Medisch Centrum (AMC), Amsterdam, The Netherlands.

Aim: Laparoscopic peritoneal lavage has increasingly been investigated as a promising alternative to sigmoidectomy for perforated diverticulitis with purulent peritonitis. Most studies only reported outcomes up to 12 months. Therefore, the objective of this study was to evaluate long-term outcomes of patients treated with laparoscopic lavage. Read More

Gan To Kagaku Ryoho 2019 Jan;46(1):145-147

Dept. of Surgery, Tsuyama Chuo Hospital.

The patient was a 59-year-old man with type 2 advanced gastric cancer in the antrum. Abdominal computed tomography revealed the primary tumor with regional lymph node metastasis. Distal gastrectomy and D2 lymph node dissection were performed. Read More

J Clin Pathol 2019 Feb 12. Epub 2019 Feb 12.

Odense PIPAC Center, Odense University Hospital, Odense, Denmark.

Aims: In this study, we investigated whether free intraperitoneal tumour cells (FITC) were detectable in ascites or peritoneal lavage fluid (PLF) from patients with peritoneal metastasis (PM) before and after treatment with pressurised intraperitoneal aerosol chemotherapy (PIPAC).

Methods: Ascites or PLF retrieved at the first and third PIPAC procedures was analysed by conventional cytology, carcinoembryonic antigen (CEA) and total protein concentration, and quantitative reverse transcriptase PCR (qRT-PCR) for mRNA expression of CEA, epithelial cell adhesion molecule (EpCAM) and cancer antigen 125 (CA-125). Conventional cytology and qRT-PCR were also performed in a negative control group (benign PLF specimens and inflammatory ascites). Read More

BJS Open 2019 Feb 29;3(1):24-30. Epub 2018 Nov 29.

Department of General Surgery John Radcliffe Hospital Oxford UK.

Background: The use of peritoneal lavage to prevent postoperative intra-abdominal abscess (IAA) after appendicectomy has been debated widely.

Methods: A systematic review and meta-analysis of suction alone lavage for appendicitis was performed to determine the relative benefit of lavage. Primary outcomes were postoperative IAA and wound infection (WI). Read More

J Trace Elem Med Biol 2019 Mar 30;52:157-165. Epub 2018 Dec 30.

Laboratorio de Biología de la Reproducción (LABIR), Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis (IMIBIO-SL), CONICET, Ejército de Los Andes 950, CP D5700HHW, San Luis, Argentina. Electronic address:

The present study was conducted to investigate whether the deficiency of tumor necrosis factor receptor p55 (TNFRp55) modulates oxidative/nitrosative stress and metallomic profile into the peritoneal cavity during the experimental endometriosis progression in mice. Female C57BL/6 mice, wild-type (WT) and TNFRp55 knockout (KO) of two months were used. Endometriosis was induced experimentally by autotransplanting three pieces of the right uterine horn to the intestinal mesentery. Read More

Curr Opin Crit Care 2019 Apr;25(2):150-156

Department of Intensive Care Medicine, Universitair Ziekenhuis Brussel, Jette.

Purpose Of Review: To review recent literature on the management of patients with severe acute pancreatitis (SAP) admitted to an ICU.

Recent Findings: SAP is a devastating disease associated with a high morbidity and mortality. Recent evidence advocates adequate risk assessment and severity prediction (including intra-abdominal pressure monitoring), tailored fluid administration favoring balanced crystalloids, withholding prophylactic antibiotic therapy, and early detection and treatment of extra-pancreatic and fungal infections. Read More

Front Pharmacol 2018 21;9:1506. Epub 2019 Jan 21.

Department of Physiology and Pathophysiology, School of Basic Medicine, Shandong University, Jinan, China.

Clinical studies showed that the use of probiotics during critical illness reduced nosocomial infection and improved clinical outcome. However, the functional mechanisms of probiotics is remains unclear. Therefore the aim of current study is to explore the protective effects and understand the underlying mechanisms for the beneficial effects of live combined and (LCBE) in cecal ligation puncture (CLP)-induced sepsis. Read More

Front Immunol 2018 17;9:3165. Epub 2019 Jan 17.

Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences (FCF), University of São Paulo (USP), São Paulo, Brazil.

may provoke peritonitis and death, especially in immunocompromized individuals such as diabetic patients. We evaluated the role of insulin in -induced peritoneal infection in diabetic and non-diabetic rats. Alloxan-diabetic male Wistar rats and their respective controls received intraperitoneal injections of different strains of or sterile phosphate-buffered saline. Read More

Cancer Manag Res 2019 17;11:831-837. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China,

Objectives: The aim of this study was to evaluate the factors associated with progress-free survival (PFS) and overall survival (OS) in patients with high-grade endometrial stromal sarcoma (HG-ESS).

Patients And Methods: A total of 40 patients were enrolled in this study at the Peking Union Medical College Hospital, Beijing, China, from 2006 to 2016. The study retrospectively analyzed clinical and pathological data, and associations of these variables with PFS and OS were evaluated. Read More

Dis Colon Rectum 2019 Jan 25. Epub 2019 Jan 25.

Background: Acute diverticulitis is a common disease with public health significance. Many studies with a high level of evidence have been published recently on the surgical management of acute diverticulitis.

Objective: The aim of this systematic review was to define the accurate surgical management of acute diverticulitis. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):1797-1799

Dept. of Digestive Surgery, Kawasaki Medical School.

Background: The median survival time(MST)of Stage Ⅳ advanced gastric cancer is reportedly 6-13 months. The standard treatment for Stage Ⅳ gastric cancer is systemic chemotherapy. With advancements in chemotherapy, the number of conversion surgery(CS)is increasing. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2063-2065

Dept. of Surgery, Tokyo Women's Medical University Medical Center East.

Several recent case reports have demonstrated long survival cases of advanced gastric cancer(AGC)patients suffering from peritoneal dissemination(PD)treatedwith effective chemotherapy; however, these AGC patients have poor prognosis in general. We report a case of AGC who hadsurvivedPD over 40 months with locoregional therapies. A 58-year-oldmale underwent distal gastrectomy for AGC with localized PD. Read More

J Surg Res 2019 Mar 6;235:607-614. Epub 2018 Dec 6.

Division of Surgical Oncology, Department of Surgery, SUNY Upstate Medical University, Syracuse, New York. Electronic address:

Background: Positive peritoneal cytology (Cyt+) even in the absence of macroscopic disease is associated with poor prognosis in patients with gastric cancer and deemed as M1 disease. Recent years have seen advancements in the evaluation strategies for peritoneal washings and management of patients with Cyt+. The aim of this review was to describe the newest paradigms in the management of patients with gastric cancer who have Cyt+ without macroscopic peritoneal metastases. Read More

Acta Med Port 2018 Dec 28;31(12):774-777. Epub 2018 Dec 28.

Serviço de Medicina Intensiva 1. Centro Hospitalar Universitário do Algarve. Unidade de Faro. Faro. Portugal.

Primary peritonitis usually occurs in patients with comorbidities previously diagnosed with ascites. However, a primary peritoneal infection in previously healthy patients may also ensue. There has been an increase in reported cases of primary peritonitis due to Streptococcus pyogenes affecting mostly women. Read More

Asian J Endosc Surg 2019 Jan 22. Epub 2019 Jan 22.

Department of Surgery, Division of Gastroenterological Surgery, Aichi Medical University, Nagakute, Japan.

Introduction: The primary concern with laparoscopic intraoperative peritoneal lavage (IOPL) for generalized peritonitis relates to the difficulty and uncertainty in ensuring adequate washout of contaminated fluid. Here, we describe a new method of laparoscopy-assisted IOPL.

Methods: We performed emergency surgery in 10 patients with generalized peritonitis necessitating IOPL. Read More

Gen Physiol Biophys 2019 Jan 18;38(1):83-90. Epub 2019 Jan 18.

Department of Pathophysiology, Faculty of Medicine, University of Niš, Niš, Serbia.

Immunomodulating effect of silica-rich water represents a novel field for research, especially regarding its features toward environmental pollutants. The aim of our study was to evaluate the effects of silica-rich water intake on systemic and peritoneal inflammation in rats that were chronically exposed to the low-level microwave (MW) radiation from mobile phones. Wistar Albino rats were exposed to 900 MHz MW radiation for 3 months. Read More

Acta Cytol 2019 9;63(1):63-72. Epub 2019 Jan 9.

Pathology Department, Shiraz University of Medical Sciences, Shiraz,

Background: Peritoneal washing cytology has become an accepted method in evaluating gynecology malignancies.

Objective: The aim of this work was to compare the conventional cytology, liquid-based cytology (LBC), and cell block in the evaluation of peritoneal fluid.

Materials And Methods: A total of 48 cases with ovarian and uterine malignancy were included in this study. Read More

World J Gastroenterol 2018 Dec;24(45):5131-5143

PLA Center of General Surgery and Pancreatic Injury and Repair Key Laboratory of Sichuan Province, Chengdu Military General Hospital, Chengdu 610083, Sichuan Province, China.

Aim: To investigate the role of peritoneal macrophage (PM) polarization in the therapeutic effect of abdominal paracentesis drainage (APD) on severe acute pancreatitis (SAP).

Methods: SAP was induced by 5% Na-taurocholate retrograde injection in Sprague-Dawley rats. APD was performed by inserting a drainage tube with a vacuum ball into the lower right abdomen of the rats immediately after the induction of SAP. Read More

Wideochir Inne Tech Maloinwazyjne 2018 Dec 30;13(4):542-545. Epub 2018 May 30.

Department of Digestive Surgery, Amiens University Hospital, Amiens, France.

Management of a perforated duodenal ulcer is most commonly performed by laparoscopy and consists of suture of the perforation after performing lavage of the peritoneal cavity. In most cases, a flap is created, and an omental flap is usually the preferred choice because of its simplicity and its proximity to the site of duodenal perforation. However, in some cases, the greater omentum cannot be used due to the severity of peritonitis or due to previous surgical removal. Read More

J Cancer Res Ther 2018 Dec;14(Supplement):S1129-S1134

Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.

Background: The factors associated with the survival and prognosis of peritoneal cytology (CY)-positive pancreatic cancer patients who undergo curative resection followed by adjuvant chemotherapy have not been established.

Patients And Methods: Both overall survival (OS) and recurrence-free survival (RFS) were examined in 23 peritoneal CY-positive pancreatic cancer patients who underwent curative resection followed by adjuvant chemotherapy between 2005 and 2015.

Results: When the length of OS was evaluated using a log-rank test, significant differences were observed in the number of metastatic lymph nodes. Read More

Oxid Med Cell Longev 2018 13;2018:6053492. Epub 2018 Nov 13.

Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brazil.

The Mediterranean diet, rich in olive oil, is beneficial, reducing the risk of cardiovascular diseases and cancer. Olive oil is mostly composed of the monounsaturated fatty acid omega-9. We showed omega-9 protects septic mice modulating lipid metabolism. Read More

Mol Immunol 2019 Jan 27;105:86-95. Epub 2018 Nov 27.

Department of Immunology, College of Basic Medical Sciences, Norman Bethune Health Science Center, Jilin University, Changchun, Jilin, China. Electronic address:

Neutrophils, classified as professional phagocytes, are crucial in killing bacteria and preventing inflammation. When studying the roles of neutrophils in the development of the septic peritonitis induced by E. coli, we noticed some of the larger cells existed among peritoneal lavage fluid cells (PLCs). Read More

Ann Transl Med 2018 Oct;6(20):400

Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital of Muenster, Muenster, Germany.

Background: There is clear evidence that early causal therapy improves outcome in sepsis and septic shock, whereas recent studies on supportive hemodynamic therapy have produced very conflictive results. The objective of the present study was to determine whether a supportive hemodynamic therapy guided by clinically relevant invasive monitoring improves survival and organ function in a high-lethality model of septic shock in sheep as compared to sole causal therapy including surgical and antimicrobial treatment.

Methods: Twenty healthy ewes were anaesthetized and instrumented for hemodynamic surveillance. Read More

J Cancer Res Ther 2018 Oct-Dec;14(6):1225-1229

Department of General Surgery, Faculty of Medicine, İstanbul University, Istanbul, Turkey.

Aim: Cytological detection of peritoneal-free gastric cancer cells is considered as the gold standard with variable sensitivity. Seeding of cancer cells after radical surgery for gastric cancer is a controversial issue. In this study, it was aimed to detect the rate of positive peritoneal washing cytology and the incidence of spreading of tumor cells after radical surgery. Read More

Surg Endosc 2018 Nov 26. Epub 2018 Nov 26.

Department of Gastrointestinal Surgery and Laboratory of Gastric Cancer, State Key Laboratory of Biotherapy, West China Hospital, Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, China.

Background: The preoperative work-up has limitations on finding peritoneal dissemination (PD) in gastric cancer patients. Laparoscopic exploration (LE) can discover radiographically occult PD, obtain accurate stage and avert futile laparotomy. The aim of our study was to introduce "Four-Step Procedure" LE in West China Hospital and further evaluate its safety and feasibility. Read More

J Nutr Biochem 2019 Feb 3;64:110-120. Epub 2018 Nov 3.

Pulmonary, Critical Care, Sleep and Allergy Division, University of Nebraska Medical Center, Omaha, NE, 68198; VA Nebraska-Western Iowa Health Care System, Omaha, NE, 68105. Electronic address:

Occupational agricultural dust exposure can cause severe lung injury, including COPD and asthma exacerbations. Cell-derived extracellular vesicles can mediate inflammatory responses and immune activation, but the contribution of diet-derived extracellular vesicles to these processes is poorly understood. We investigated whether bovine milk-derived extracellular vesicles modulate inflammatory responses to agricultural dust exposures in a murine model. Read More

Vet Immunol Immunopathol 2018 Nov 15;205:1-9. Epub 2018 Oct 15.

Department of Biology, University of Waterloo, 200 University Ave W., Waterloo, ON, N2L 3G1 Canada. Electronic address:

Telemetry transmitters are frequently used in studies of wild fish migration and behavior. Although the effects of surgically implanted transmitters on survival, tag retention, healing and growth have been studied, there has been little research regarding the potential immune response induced by these transmitters. In the current study, mature rainbow trout received either surgical implantation of an acoustic transmitter or a sham surgical procedure. Read More

Indian Pediatr 2018 Oct;55(10):909-910

Department of Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, Shahdara, Delhi, India.

Background: Clinical presentations of intestinal lymphangiectasia include pitting edema, chylous ascites, pleural effusion, diarrhea, malabsorption and intestinal obstruction.

Case Characteristics: An 8-year-old male child presented to the emergency department with clinical features of peritonitis, raising suspicion of appendicular or small bowel perforation.

Intervention/outcome: Diagnosis of chylous ascites with primary intestinal lymphangiectasia made on laparotomy. Read More

J Diabetes Res 2018 22;2018:6209694. Epub 2018 Oct 22.

Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, Brazil.

Paracoccidioidomycosis, a key issue for Brazilian health service, can be aggravated in patients with impaired immunological responses, such as diabetic patients. We evaluated the role of insulin in inflammatory parameters in diabetic and nondiabetic mice using a systemic mycosis (Pb) model. Diabetic C57BL-6 mice and controls were infected with Pb18 and treated with insulin for 12 days prior to experiments. Read More

Pathol Res Pract 2019 Feb 28;215(2):392-394. Epub 2018 Oct 28.

Liquid Biopsy Laboratory, Medical Oncology Department, Hospital Universitario Puerta de Hierro, Spain; Familial Cancer Unit, Medical Oncology Department, Hospital Universitario Puerta de Hierro, Spain. Electronic address:

Genetic screening for BRCA mutations should be offered to all women diagnosed with epithelial ovarian, fallopian tube, and/or peritoneal cancers given the implications for treatment options and cancer risk assessments. Yet, while germline breast cancer susceptibility gene 1 (BRCA1) and breast cancer susceptibility gene 2 (BRCA2) testing is commonly performed, BRCA1/2 somatic mutations testing is rather challenging since the poor quality of DNA extracted from formalin fixed paraffin embedded (FFPE) samples can significantly impair this process. Peritoneal lavage is routinely performed in surgeries of suspected ovarian malignancies. Read More

J Cell Physiol 2019 Apr 28;234(4):4081-4094. Epub 2018 Oct 28.

Department of Biotechnology and Animal Science, National Ilan University, Yilan, Taiwan.

Dysregulation of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is involved in many chronic inflammatory diseases, including gouty arthritis. Activation of the NLRP3 inflammasome requires priming and activation signals: the priming signal controls the expression of NLRP3 and interleukin (IL)-1β precursor (proIL-1β), while the activation signal leads to the assembly of the NLRP3 inflammasome and to caspase-1 activation. Here, we reported the effects of the alcoholic extract of Taiwanese green propolis (TGP) on the NLRP3 inflammasome in vitro and in vivo. Read More

Front Immunol 2018 12;9:2370. Epub 2018 Oct 12.

Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong.

Current influenza vaccines have relatively low effectiveness, especially against antigenically drifted strains, the effectiveness is even lower in the elderly and immunosuppressed individuals. We have previously shown in a randomized clinical trial that the topical application of a toll-like receptor 7 agonist, imiquimod, just before intradermal influenza vaccine could expedite and augment antibody response, including to antigenically-drifted strains. However, the mechanism of this vaccine and imiquimod combination approach is poorly understood. Read More

Exp Parasitol 2018 Dec 16;195:44-53. Epub 2018 Oct 16.

Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

Toxoplasmosis is a worldwide parasitic disease responsible for serious health problems to human. The currently available drugs used for toxoplasmosis treatment showed a limited efficacy and cause serious host toxicity. The in vitro screening for toxoplasmicidal activity of Araucaria heterophylla resin (AHR) extract and its major component 13-epi-cupressic acid (CUP) showed that both AHR (EC = 3. Read More

Pharmacol Rep 2018 Dec 19;70(6):1150-1157. Epub 2018 Jul 19.

Smooth Muscle and Molecular Pharmacology Laboratory, Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, U.P. Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU), Mathura, Uttar Pradesh, India. Electronic address:

Background: Endocannabinoids level are reported to increase in sepsis, however, the role of vascular cannabinoid receptor-1 (CB1R) in sepsis-induced vascular hyporeactivity is yet to be unravelled.

Methods: Polymicrobial sepsis was induced by caecal ligation and puncture in mice. Isometric tension in isolated aortic rings during early (6 h) and late (20 h) phases of sepsis was recorded and expression of mRNA of monoacylglycerol lipase (MAGL) and cannabinoid receptor-1 (CB1R) was investigated. Read More

Asian J Surg 2019 Mar 10;42(3):477-481. Epub 2018 Oct 10.

Department of Hepatobiliary & Pancreatovascular Surgery, First Affiliated Hospital of Xiamen University, Xiamen, China. Electronic address:

Little is known about the clinical outcome of pancreaticoduodenectomy (PD) for locally advanced gastric cancer invading the duodenum and/or pancreas. The aim of this study was to define the clinical outcome and prognostic determinants of PD for locally advanced gastric cancer through a systematic review and pooled analysis of relevant data in the literature. A total of 13 articles involving 69 patients were eligible for inclusion. Read More

J Immunol 2018 Nov 12;201(10):2998-3005. Epub 2018 Oct 12.

Pharmacology and Experimental Therapeutics Unit, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel; and

CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined. In this study, employing a mouse model of allergic peritonitis, we demonstrate that CD300a expression on peritoneal cells is regulated from inflammation to resolution. Allergic peritonitis-induced CD300a mice had a rapid increase in their inflammatory cell infiltrates and tryptase content in the peritoneal cavity compared with wild type, and their resolution process was significantly delayed. Read More

BMC Cancer 2018 Oct 12;18(1):974. Epub 2018 Oct 12.

Department of Gastroenterology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.

Background: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for mucinous cystic neoplasm of the pancreas carries a potential risk of inducing peritoneal tumor cell dissemination. We investigated the diagnostic yield and safety of EUS-FNA-based cytology of cells obtained from the pancreatic invasion site of intraductal papillary-mucinous neoplasm-derived adenocarcinoma (IPMC).

Methods: We included 22 surgically resected IPMCs and 84 pancreatic ductal adenocarcinomas (PDACs). Read More