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Surg Today 2022 Jun 29. Epub 2022 Jun 29.

Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Purpose: Peritoneal dissemination is the key to the prognosis of gastric cancer (GC) and can be detected early with peritoneal lavage cytology. No studies have examined preoperative prognostic factors in GC patients who have positive cytology but no other non-curative factors.

Methods: We conducted a retrospective analysis using a multicenter database of 3575 patients who underwent gastrectomy between 2010 and 2014. Read More

J Surg Res 2022 Jun 15;279:8-16. Epub 2022 Jun 15.

Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, China. Electronic address:

Introduction: The T cell immunoglobulin and mucin domain 3 (Tim-3) mediated immunosuppressive pathway has been shown to play an essential role in the development of sepsis. However, the influence of Tim-3 blockade during sepsis and the possible effects on T cells' function remains largely unknown. Our study investigates the role of Tim-3 in cecal ligation and puncture (CLP)-induced sepsis in mice. Read More

Am J Transl Res 2022 15;14(5):3066-3078. Epub 2022 May 15.

Department of Anesthesiology, Second Military Medical University Affiliated Eastern Hepatobiliary Surgery Hospital 255 Changhai Road, Yangpu District, Shanghai, China.

Chronic pelvic pain (CPP) and infertility are the common characteristics of endometriosis. Macrophages and related inflammation play important roles in endometriosis pain. TRPV1 and TRPA1 form a heteromeric channel which is related to endometriosis pain. Read More

Biomed Res Int 2022 2;2022:9528444. Epub 2022 Jun 2.

Oncology Department of Northern Jiangsu People's Hospital Affiliated to Yangzhou University, 225000, China.

The paper is written to investigate the levels and significance of tumor markers [carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), and carbohydrate antigen 19-9 (CA19-9)] and cytokines [interleukin-6 (IL-6), IL-4, and IL-2] in serum and peritoneal lavage fluid of patients with peritoneal metastasis of gastric cancer. For this research, 145 patients with gastric cancer treated in our hospital were divided into peritoneal metastasis group ( = 25), other metastasis group ( = 32), and nonmetastasis group ( = 88) according to the occurrence of metastasis. At the same time, the levels of serum tumor markers and cytokines and tumor markers and cytokines in intraoperative peritoneal lavage fluid were compared among the three groups. Read More

Front Immunol 2022 20;13:870627. Epub 2022 May 20.

Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Aberrant activation of the NLRP3 inflammasome promotes the pathogenesis of many inflammatory diseases. The development of the NLRP3 inflammasome inhibitors from existing drugs for new therapeutic purposes is becoming more important. Candesartan is an angiotensin II receptor antagonist widely used as a blood pressure-lowering drug; however, the inhibitory potential of candesartan on the NLRP3 inflammasome has not yet been investigated. Read More

Ann Surg Oncol 2022 Jun 4. Epub 2022 Jun 4.

Section of Hepatopancreatobiliary Surgery, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

Int J Surg Case Rep 2022 May 28;94:107130. Epub 2022 Apr 28.

Department of General Surgery, Zaghouen Hospital, Tunisia; Faculty of Medicine of Tunis, Tunis El Manar University, Tunis, Tunisia.

Introduction And Importance: Jejunal divertica is a rare entity with an often clinically silent course. However, it may be associated to life-threatening complications such as perforation. Therefore it should be considered in every case of acute abdomen. Read More

Surg Endosc 2022 May 23. Epub 2022 May 23.

Department of Surgery, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

Background: This study aimed to compare laparoscopic lavage and sigmoidectomy as treatment for perforated diverticulitis with purulent peritonitis during a 36 month follow-up of the LOLA trial.

Methods: Within the LOLA arm of the international, multicentre LADIES trial, patients with perforated diverticulitis with purulent peritonitis were randomised between laparoscopic lavage and sigmoidectomy. Outcomes were collected up to 36 months. Read More

World J Clin Oncol 2022 Apr;13(4):303-313

Peritoneal Surface Malignancy Center, Kishiwada Tokushukai Hospital, Osaka 596-8522, Japan.

Background: Solitary fibrous tumors are rare neoplasms of mesenchymal origin. They are often of low malignant potential and rarely metastasize. They frequently arise from the pleura and can occur at any soft tissue site in the body. Read More

Cells 2022 04 24;11(9). Epub 2022 Apr 24.

Institute of Biochemistry, Medical School, Justus-Liebig-University, 35392 Giessen, Germany.

Self-extracellular RNA (eRNA), which is released under pathological conditions from damaged tissue, has recently been identified as a new alarmin and synergistic agent together with toll-like receptor (TLR)2 ligands to induce proinflammatory activities of immune cells. In this study, a detailed investigation of these interactions is reported. The macrophage cell line J774 A. Read More

Clin J Gastroenterol 2022 May 11. Epub 2022 May 11.

Department of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Mucinous cystadenocarcinoma (MCAC) with malignant ascites is rare. We report a case of a 28-year-old woman who presented with epigastric pain. The ascites in the Douglas fossa was identified at a nearby gynecology clinic. Read More

J Immunol 2022 Jun 9;208(11):2515-2522. Epub 2022 May 9.

National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Tuberculosis, The Third People's Hospital of Shenzhen, Southern University of Science and Technology, Shenzhen, China;

The cannabinoid receptor 2 (CB2) is a receptor mainly expressed in immune cells and believed to be immunosuppressive in infective or inflammatory models. However, its role in sepsis has not been fully elucidated. In this study, we delineate the function and mechanism of CB2 in the cecal ligation and puncture-induced septic model in mice. Read More

J Pediatr Surg Case Rep 2022 Jul 4;82:102289. Epub 2022 May 4.

Department of Paediatric Surgery, Faculty of Medicine, Comenius University, National Institute of Children's Diseases, Bratislava, Slovakia.

Purpose: Various manifestations of coronavirus (SARS-CoV-2) have been reported since the pandemic began. Some articles have reported acute pancreatitis in adult patients due to COVID-19 infection. To our knowledge this is the first report of acute hemorrhagic necrotizing pancreatitis in children associated with SARS-CoV-2 infection. Read More

Evid Based Complement Alternat Med 2021 22;2021:6626483. Epub 2021 Sep 22.

Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225009, China.

Background: Huangkui capsule (HKC) comprises the total flavonoid extract of flowers of (L.) Medicus. This study aimed to explore the effects of HKC on lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice and LPS-stimulated RAW 264. Read More

Evid Based Complement Alternat Med 2022 21;2022:6238162. Epub 2022 Apr 21.

Department of Histology and Embryology, Mudanjiang Medical University, Mudanjiang 157011, China.

(MP), an atypical bacterium, is a common pathogenetic organism of respiratory infection in children. In the present study, we analyzed the beneficial role of fucoxanthin (Fx), a marine carotenoid, in a murine model of MP. C57BL/6 mice were inoculated once intranasally with 10 CFU of , and we found that Fx treatment markedly decreased BAL (quantitative bronchoalveolar lavage) concentrations and alleviated airway obstruction in the infected mice. Read More

Pancreatology 2022 Jun 9;22(5):583-589. Epub 2022 Apr 9.

Department of Surgery, Graduate School of Biochemical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Background: The preoperative risk factors for positive peritoneal lavage cytology (CY) are unknown, especially in patients who received neoadjuvant therapy. In addition, the optimal indications for staging laparoscopy (SL) are still unclear. The aim of this study was to investigate the preoperative risk factors of CY positivity in patients with pancreatic ductal adenocarcinoma (PDAC) treated with surgical resection and to determine the optimal indications for SL. Read More

Ann Surg Oncol 2022 Apr 21. Epub 2022 Apr 21.

Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan.

Background: The prognostic significance of peritoneal lavage cytology (PLC) in patients with pancreatic ductal adenocarcinoma (PDAC) remains controversial. The purpose of this study was to evaluate the prognostic impact of PLC status in PDAC patients.

Methods: Patients intending to undergo resection for PDAC between 2007 and 2020 were included. Read More

Ann Surg Oncol 2022 Apr 19. Epub 2022 Apr 19.

Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan.

Int J Mol Sci 2022 Apr 4;23(7). Epub 2022 Apr 4.

Department of Food Science and Biotechnology, National Chung Hsing University, Taichung 40227, Taiwan.

Menthone is rich in × L. essential oil and it has anti-inflammatory properties; research shows that it is useful, via percutaneous absorption, in treating inflammation-related diseases. However, anti-allergic inflammatory effects of volatile menthone have not yet been used to treat allergic asthma, in vivo. Read More

Cancers (Basel) 2022 Mar 31;14(7). Epub 2022 Mar 31.

Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA 90095, USA.

Intraperitoneal (i.p.) experimental models in mice can recapitulate the process of i. Read More

Facts Views Vis Obgyn 2022 Mar;14(1):59-68

Background: A possible solution to the problem of cell dissemination through laparoscopic uncontained morcellation during laparoscopic supracervical hysterectomy (LASH) is the use of laparoscopic in-bag morcellation. One criticism regarding the use of in-bag morcellation is the additional surgical time associated with this procedure.

Objectives: In this retrospective study we compared the total surgical time in LASH with laparoscopic in-bag morcellation (107 cases from 2016-2018) and LASH with uncontained morcellation (47 cases from 2015-2017). Read More

Front Immunol 2022 18;13:853894. Epub 2022 Mar 18.

The Biotherapy Center, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Mesenchymal stem cells (MSCs) show promising therapeutic potential in treating inflammatory bowel disease (IBD), and intraperitoneal delivery of MSCs have become a more effective route for IBD treatment. However, the underlying mechanisms are still poorly understood. Here, we found that intraperitoneally delivered MSCs significantly alleviated experimental colitis. Read More

Front Pharmacol 2022 11;13:838873. Epub 2022 Mar 11.

School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China.

Diels et Gilg (Sanyeqing, SYQ) has traditionally been used to treat inflammation, high fever and improve immune function of patients. Polysaccharides have been proved to be one of the important components of SYQ. Previous studies have confirmed the antipyretic and antitumor effects of polysaccharides from SYQ (SYQP), and clarified that SYQP could enhance immunity through TLR4 signalling pathway. Read More

Gastric Cancer 2022 Jul 4;25(4):712-725. Epub 2022 Apr 4.

Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Background: The prognosis of gastric cancer patients with peritoneal dissemination is extremely poor and effective treatment for peritoneal dissemination has not been established. Gastric cancer-derived small extracellular vesicles play an important role in the development of a favorable microenvironment for peritoneal metastasis and progression of peritoneal dissemination. Here, we aimed to investigate the transformation of gastric cancer cells by removing gastric cancer-derived small extracellular vesicles and to develop a novel therapy for inhibiting peritoneal dissemination. Read More

Front Immunol 2022 9;13:827004. Epub 2022 Mar 9.

Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.

is an intracellular protozoan that mainly infects cattle to cause abortion and significant economic losses worldwide. A better understanding of the immune evasion mechanisms of could help to search for an effective approach to prevent and treat neosporosis. Mitophagy is used by some viruses to evade host immune surveillance. Read More

Biomolecules 2022 03 14;12(3). Epub 2022 Mar 14.

Department of Physiology, College of Medicine, Ewha Womans University, Seoul 07804, Korea.

Signal transducer and activator of transcription 6 (STAT6) promotes an anti-inflammatory process by inducing the development of M2 macrophages. We investigated whether modulating STAT6 activity in macrophages using AS1517499, the specific STAT6 inhibitor, affects the restoration of homeostasis after an inflammatory insult by regulating PPARγ expression and activity. Administration of AS1517499 suppressed the enhanced STAT6 phosphorylation and nuclear translocation observed in peritoneal macrophages after zymosan injection. Read More

Am J Emerg Med 2022 Jun 10;56:393.e1-393.e4. Epub 2022 Mar 10.

Emergency Department, Medical Director, Kettering Health Hamilton, United States of America.

Background: Severe hypothermia can result in malignant arrhythmias or cardiac arrest and require invasive central rewarming modalities due to a core body temperature < 28 °C. Difficult rescue missions can make continuous CPR challenging, but the decrease in oxygen consumption at these low temperatures allows for successful recovery despite the delay. Although other active warming techniques, such as peritoneal lavage, intravascular warming catheter, and renal replacement therapy can be beneficial, the consensus statements recommend extracorporeal life support as the preferred rewarming method. Read More

Pharmacol Res 2022 04 9;178:106172. Epub 2022 Mar 9.

Pharmacology and Experimental Therapeutics Unit, School of Pharmacy, Institute for Drug Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. Electronic address:

Background: Cromolyn Sodium (CS) has been used in the past as an anti-allergy drug owing to its mast cell (MC) stabilizing properties that impair histamine release. However, additional mechanisms for its clinical actions are likely and might help to identify new roles for MCs and leukocytes in regulating inflammation. Here, using human cord blood-derived MCs (CBMCs), mouse bone marrow-derived MCs (BMMCs) and eosinophils (BMEos), and in vivo mouse models of allergic inflammation (AI), additional actions of CS on MCs were determined. Read More

Sci Rep 2022 03 7;12(1):3646. Epub 2022 Mar 7.

Department of Pediatric Surgery, School of Medicine, Izmir Katip Çelebi University, Izmir, 35620, Turkey.

Accurate and timely diagnosis of appendicitis in children can be challenging, which leads to delayed admittance or misdiagnosis that may cause perforation. Surgical management involves the elimination of the focus (appendectomy) and the reduction of the contamination with peritoneal irrigation to prevent sepsis. However, the validity of conventional irrigation methods is being debated, and novel methods are needed. Read More

Gan To Kagaku Ryoho 2022 Feb;49(2):161-165

Dept. of Surgery, Saiseikai Yokohamashi Tobu Hospital.

Objective: We examined the applicability and safety of staging laparoscopy(SL)in the treatment of advanced gastric cancer.

Methods: We retrospectively reviewed the gastric cancer cases that were examined using SL between January 2015 and December 2019 at our hospital.

Results: Within this period, 59 gastric cancer patients underwent SL, of whom 53 were diagnosed with SL at first examination. Read More