1,668 results match your criteria Diagnostic Pathology [Journal]


Applications of molecular neuro-oncology - a review of diffuse glioma integrated diagnosis and emerging molecular entities.

Diagn Pathol 2019 Apr 9;14(1):29. Epub 2019 Apr 9.

Knight Diagnostic Laboratories and Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, 97239, USA.

Insights into the molecular underpinnings of primary central nervous system tumors have radically changed the approach to tumor diagnosis and classification. Diagnostic emphasis has shifted from the morphology of a tumor under the microscope to an integrated approach based on morphologic and molecular features, including gene mutations, chromosomal copy number alterations, and gene rearrangements. In 2016, the World Health Organization provided guidelines for making an integrated diagnosis that incorporates both morphologic and molecular features in a subset of brain tumors. Read More

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http://dx.doi.org/10.1186/s13000-019-0802-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457044PMC
April 2019
1 Read

Orthokeratinized odontogenic cyst (OOC): Clinicopathological and radiological features of a series of 10 cases.

Diagn Pathol 2019 Apr 4;14(1):28. Epub 2019 Apr 4.

Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan.

Background: Orthokeratinized Odontogenic Cyst (OOC) is a rare, developmental odontogenic cyst which was considered in the past to be a variant of Odontogenic keratocyst (OKC) later renamed as keratocystic odontogenic tumor (KCOT). The treatment of OOC is by enucleation and the prognosis, following enucleation is excellent with a recurrence rate of less than 2%. On the other hand, OKC has a recurrence rate between 8 and 25% after enucleation. Read More

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http://dx.doi.org/10.1186/s13000-019-0801-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449939PMC

Mesenteric extraovarian Sertoli-Leydig cell tumor without DICER1 hotspot mutation: a case report.

Diagn Pathol 2019 Apr 1;14(1):27. Epub 2019 Apr 1.

Department of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, 19-1, Morioka, 020-8505, Japan.

Background: Ovarian Sertoli-Leydig cell tumors (SLCTs) with androgenic manifestations harbor DICER1 mutations in 30-60% of cases. Ovarian SLCTs without DICER1 hotspot mutations have been reported to exhibit elderly onset and no androgenic manifestations. We present the first case of a primary mesenteric SLCT without DICER1 hotspot mutation. Read More

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http://dx.doi.org/10.1186/s13000-019-0805-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444432PMC
April 2019
2 Reads

Three-dimensional histopathological reconstruction of bladder tumours.

Diagn Pathol 2019 Mar 28;14(1):25. Epub 2019 Mar 28.

Department of Biomedical Engineering and Physics, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Background: Histopathological analysis is the cornerstone in bladder cancer (BCa) diagnosis. These analysis suffer from a moderate observer agreement in the staging of bladder cancer. Three-dimensional reconstructions have the potential to support the pathologists in visualizing spatial arrangements of structures, which may improve the interpretation of specimen. Read More

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http://dx.doi.org/10.1186/s13000-019-0803-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440143PMC

Rare myeloid sarcoma with KMT2A (MLL)-ELL fusion presenting as a vaginal wall mass.

Diagn Pathol 2019 Mar 28;14(1):26. Epub 2019 Mar 28.

Department of Pathology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, ward 3-140, Chicago, IL, 60611, USA.

Backgroud: Myeloid sarcoma (MS) is a rare neoplasm of immature myeloid precursors that form tumor mass outside the bone marrow. The diagnosis of de novo MS can be challenging, particularly in patients with no prior history of hematologic malignancies or when MS involves unusual anatomic sites.

Case Presentation: The patient was a 53-year-old woman with a history of uterine fibroids and vaginal bleeding for many years who presented with a vaginal wall mass. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-019-0804-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440110PMC
March 2019
3 Reads

Changes in plasma EBV-DNA and immune status in patients with nasopharyngeal carcinoma after treatment with intensity-modulated radiotherapy.

Diagn Pathol 2019 Mar 14;14(1):23. Epub 2019 Mar 14.

Department of Radiotherapy, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, 318000, People's Republic of China.

Background: Previous studies reported the early diagnostic values of plasma Epstein-Barr virus (EBV)-DNA. The present study aimed to assess the relationship between the concentration of plasma EBV-DNA and the number of CD8PD-1(programmed cell death-1,PD-1) and regulatory T (Treg) cells in patients with nasopharyngeal carcinoma (NPC) who were treated with intensity-modulated radiotherapy (IMRT).

Methods: This study included 37 patients treated with IMRT. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-019-0798-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417170PMC
March 2019
3 Reads
2.411 Impact Factor

Detection of SS18-SSX1/2 fusion transcripts in circulating tumor cells of patients with synovial sarcoma.

Diagn Pathol 2019 Mar 14;14(1):24. Epub 2019 Mar 14.

Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland.

A recent study on 15 patients with synovial sarcoma demonstrated very low prevalence of tumor-specific fusion transcripts in peripheral blood specimens. Our results in an independent cohort of 38 patients with synovial sarcoma support these findings. Synovial sarcoma patients could greatly benefit from a non-invasive monitoring of tumor burden by liquid biopsies. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-019-0800-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419438PMC
March 2019
6 Reads

Malakoplakia of the colon following renal transplantation in a 73 year old woman: report of a case presenting as intestinal perforation.

Diagn Pathol 2019 Mar 13;14(1):22. Epub 2019 Mar 13.

Department of Radiology, Maisonneuve-Rosemont Hospital, 5415 Boulevard de L'Assomption, Montreal, QC, Canada.

Background: Malakoplakia is a chronic inflammatory disease characterized by tissue infiltrates of large granular macrophages containing distinctive intracytoplasmic inclusions termed Michaelis-Gutmann (MG) bodies. The genitourinary system is the most commonly involved site, followed by the gastrointestinal tract. Malakoplakia may occur as a complication of primary or secondary immunosuppression and, therefore, renal transplant recipients are at risk. Read More

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http://dx.doi.org/10.1186/s13000-019-0799-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416959PMC
March 2019
2 Reads

Melanoma arising in a Giant congenital melanocytic nevus: two case reports.

Diagn Pathol 2019 Feb 19;14(1):21. Epub 2019 Feb 19.

Federal State Budgetary Institution, "N.N. Blokhin Medical Research Center of Oncology" of the Ministry of Health of the Russian Federation, 115478 Kashirskoye shosse, 24, Moscow, Russian Federation.

Background: A giant congenital melanocytic nevus (GCMN) is found in 0.1% of live-born infants. If present, the lesion has a chance of about 6% to develop into malignant melanoma. Read More

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http://dx.doi.org/10.1186/s13000-019-0797-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381634PMC
February 2019
2 Reads

A dedifferentiated solitary fibrous tumor of the parotid gland: a case report with Cytopathologic findings and review of the literature.

Diagn Pathol 2019 Feb 18;14(1):20. Epub 2019 Feb 18.

Department of Otorhinolaryngology, Kung Tien General Hospital, Shalu, Taichung, Taiwan.

Background: Solitary fibrous tumor (SFT) is a ubiquitous mesenchymal neoplasm but it rarely occurs in the parotid gland. The histological features are variable, with the majority having spindle cell morphology and non-specific branching (staghorn) ecstatic vascular pattern. SFT ranges from benign to overtly malignant. Read More

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http://dx.doi.org/10.1186/s13000-019-0792-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379935PMC
February 2019

Histologic findings associated with laser interstitial thermotherapy for glioblastoma multiforme.

Diagn Pathol 2019 Feb 15;14(1):19. Epub 2019 Feb 15.

Department of Neurological Surgery, The Ohio State University Wexner Medical Center, 410 West 10th Avenue, Doan 1047, Columbus, OH, 43210, USA.

Background: Laser-interstitial thermal therapy (LITT) has been supported by some authors as an ablative treatment of glioblastoma multiforme (GBM). Although the effects of LITT have been modeled in vivo, the histologic effects in a clinical circumstance have not been described. We analyzed tissue from a patient who underwent LITT as primary treatment for GBM. Read More

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http://dx.doi.org/10.1186/s13000-019-0794-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376796PMC
February 2019

Analysis of the frequency of oncogenic driver mutations and correlation with clinicopathological characteristics in patients with lung adenocarcinoma from Northeastern Switzerland.

Diagn Pathol 2019 Feb 11;14(1):18. Epub 2019 Feb 11.

Institute of Pathology and Molecular Pathology, Clinical Pathology, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.

Background: Molecular testing of lung adenocarcinoma for oncogenic driver mutations has become standard in pathology practice. The aim of the study was to analyze the EGFR, KRAS, ALK, RET, ROS1, BRAF, ERBB2, MET and PIK3CA mutational status in a representative cohort of Swiss patients with lung adenocarcinoma and to correlate the mutational status with clinicopathological patient characteristics.

Methods: All patients who underwent molecular testing of newly diagnosed lung adenocarcinoma during a 4-year period (2014-2018) were included. Read More

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http://dx.doi.org/10.1186/s13000-019-0789-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371584PMC
February 2019
7 Reads

Concurrent isolated retroperitoneal HGSC and STIC defined by somatic mutation analysis: a case report.

Diagn Pathol 2019 Feb 11;14(1):17. Epub 2019 Feb 11.

Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan.

Background: Retroperitoneal high-grade serous carcinoma (HGSC) is extremely rare and the origin remains unclear. We present a case of retroperitoneal HGSC and coexisting serous tubal intraepithelial carcinoma (STIC), which is considered as the main origin of ovarian HGSC. We reviewed the available literature and discussed about the origin of this rare disease. Read More

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http://dx.doi.org/10.1186/s13000-019-0795-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371506PMC
February 2019
7 Reads

Widely metastatic IDH1-mutant glioblastoma with oligodendroglial features and atypical molecular findings: a case report and review of current challenges in molecular diagnostics.

Diagn Pathol 2019 Feb 9;14(1):16. Epub 2019 Feb 9.

Brain Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, 1550 Orleans Street, 1M16, Baltimore, MD, 21287, USA.

Background: Gliomas with 1p/19q-codeletion as well as mutation of isocitrate dehydrogenase (IDH) 1 are typically characterized as oligodendrogliomas with comparatively good response to treatment with radiation and chemotherapy.

Case Presentation: We present the case of a 28-year-old man with an IDH1 and TP53 mutant high grade glioma with abnormalities in chromosomes 1 and 19 suggestive of anaplastic oligodendroglioma that rapidly progressed to widespread metastatic disease. Biopsy of a liver lesion confirmed metastasis of the patient's known brain primary and chemotherapy with temozolomide was initiated. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-019-0793-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368694PMC
February 2019
5 Reads

Identification of novel GNAS mutations in intramuscular myxoma using next-generation sequencing with single-molecule tagged molecular inversion probes.

Diagn Pathol 2019 Feb 8;14(1):15. Epub 2019 Feb 8.

Department of Pathology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands.

Background: Intramuscular myxoma (IM) is a hypocellular benign soft tissue neoplasm characterized by abundant myxoid stroma and occasional hypercellular areas. These tumors can, especially on biopsy material, be difficult to distinguish from low-grade fibromyxoid sarcoma or low-grade myxofibrosarcoma. GNAS mutations are frequently involved in IM, in contrast to these other malignant tumors. Read More

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http://dx.doi.org/10.1186/s13000-019-0787-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368757PMC
February 2019
1 Read

Expression of cyclin D1 in clear cell sarcoma of kidney. Is it useful in differentiating it from its histological mimics?

Diagn Pathol 2019 Feb 8;14(1):13. Epub 2019 Feb 8.

Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan.

Background: Clear cell sarcoma of the kidney (CCSK) is a rare malignant pediatric renal neoplasm with a heterogeneous histological appearance which often results in misdiagnosis. There are no specific immunohistochemical markers which can help in differentiating CCSK from other pediatric renal neoplasms. Recently Cyclin D1 has been investigated as a possible marker in this regard. Read More

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http://dx.doi.org/10.1186/s13000-019-0790-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368701PMC
February 2019
3 Reads

Role of apoptotic, autophagic and senescence pathways in minor salivary gland adenoid cystic carcinoma.

Diagn Pathol 2019 Feb 8;14(1):14. Epub 2019 Feb 8.

Department of Oral Pathology, São Leopoldo Mandic Research Institute, Rua José Rocha Junqueira, 13, CEP, Campinas, SP, 13045-610, Brazil.

Background: Adenoid cystic carcinoma (ACC) is a salivary gland malignancy with poor long-term survival, which warrants studies aimed at clarifying the pathogenesis of this disease in order to widen the scope of therapeutic options currently available. Alterations in regulatory mechanisms relating to vascular support, cell death and autophagy are important pathways for tumor growth in cancer. Thus, the present study aimed to access vascular supply, apoptosis, autophagy and cell senescence in ACC of minor salivary glands. Read More

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http://dx.doi.org/10.1186/s13000-019-0796-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368765PMC
February 2019
1 Read

Primary renal well-differentiated neuroendocrine tumors: report of six cases with an emphasis on the Ki-67 index and mitosis.

Diagn Pathol 2019 Feb 7;14(1):12. Epub 2019 Feb 7.

Department of Pathology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: Primary renal well-differentiated neuroendocrine tumors (WDNETs) also called carcinoid and atypical carcinoid are extremely rare, and little is known about parameters that may predict prognosis at diagnosis.

Methods: Six cases of primary renal WDNET were collected. After reviewing slides stained with hematoxylin and eosin, proportions of each growth pattern were determined. Read More

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http://dx.doi.org/10.1186/s13000-019-0791-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367815PMC
February 2019
5 Reads

Detection of pagetoid urothelial intraepithelial neoplasia extending to the vagina by cervical screening cytology: a case report with renewed immunochemical summary.

Diagn Pathol 2019 Feb 2;14(1). Epub 2019 Feb 2.

Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute Hospital, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.

Background: Pagetoid spread of urothelial carcinoma (UC) to the lower genital tract is quite a rare and diagnostically challenging condition. Pagetoid urothelial intraepithelial neoplasia extending to the vagina is difficult to diagnose, especially in remote recurrences without symptomatic or macroscopic lesions typical to Paget disease. However, its identification by cervical screening cytology is important because UC is often characterized by a long history of relapse. Read More

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http://dx.doi.org/10.1186/s13000-019-0788-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359825PMC
February 2019
5 Reads

Elevated expression of ciRS-7 in peripheral blood mononuclear cells from rheumatoid arthritis patients.

Diagn Pathol 2019 Feb 2;14(1):11. Epub 2019 Feb 2.

Department of Laboratory Medicine, The Affiliated People's Hospital, Jiangsu University, Zhenjiang, 212002, China.

Background: Circular RNAs (circRNAs) represent a class of widespread and variety endogenous RNAs that may regulate gene expression. Thousands of mammalian circRNAs harbor miRNA response elements (MREs), suggesting a potential role as competitive endogenous RNAs (ceRNAs). Recent studies have demonstrated that ciRS-7 (circular CDR1 antisense), which acts as a powerful miR-7 sponge, contains more than 70 putative binding sites for miR-7 and may inhibit its target genes. Read More

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http://dx.doi.org/10.1186/s13000-019-0783-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359828PMC
February 2019

Pathological diagnosis of thyroid nodules based on core needle biopsies: comparative study between core needle biopsies and resected specimens in 578 cases.

Diagn Pathol 2019 Feb 2;14(1):10. Epub 2019 Feb 2.

Department of Pathology, Peking University First Hospital, 7 Xishiku Street, Xicheng District, Beijing, 100034, China.

Background: Pathological diagnosis based on core needle biopsy (CNB) should be different from a resected specimen because it is difficult to apply the histological criteria established for resected specimens to CNB due to sampling limitations. A pathological classification for thyroid nodule on CNB was first proposed by the Korean Group in 2015. The objective of this study was to test the reliability and clinical value of this proposal. Read More

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http://dx.doi.org/10.1186/s13000-019-0786-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359785PMC
February 2019

Diagnostic errors in fatal medical malpractice cases in Shanghai, China: 1990-2015.

Diagn Pathol 2019 Jan 31;14(1). Epub 2019 Jan 31.

Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, 138 Yixueyuan Road, Xuhui District, Shanghai, 200032, People's Republic of China.

Background: Medical disputes remain unabated in China. Previous studies have shown the changes of diagnostic discrepancy over time in developed countries, but diagnostic discrepancy remains understudied in China, especially in the setting of medical disputes. We sought to describe the year-based changes of diagnostic discrepancies in medical disputes, and to identify factors associated with classes of diagnostic discrepancy. Read More

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http://dx.doi.org/10.1186/s13000-019-0785-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357365PMC
January 2019
1 Read

RRBP1 overexpression is associated with progression and prognosis in endometrial endometrioid adenocarcinoma.

Diagn Pathol 2019 Jan 26;14(1). Epub 2019 Jan 26.

Department of Gynecology, Harbin Medical University Cancer Hospital, Harbin, 150081, China.

Background: Currently, ribosome-binding protein 1 (RRBP1) is considered to be a novel oncogene that is overexpressed in colorectal cancer, lung cancer, mammary cancer, esophageal cancer and other carcinomas. However, the relationship between RRBP1 and endometrioid-type endometrial carcinoma (EC) remains unknown. Our purpose is to explore the function of RRBP1 in endometrioid-type endometrial carcinoma. Read More

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http://dx.doi.org/10.1186/s13000-019-0784-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347782PMC
January 2019
7 Reads

PD-L1 expression and its clinicopathological correlation in advanced esophageal squamous cell carcinoma in a Chinese population.

Diagn Pathol 2019 Jan 26;14(1). Epub 2019 Jan 26.

Department of Pathology and Resident Training Base, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Background: Programmed death ligand 1 (PD-L1) is a ligand for the inhibitory programmed cell death protein 1 (PD-1), which are targeted by several anti-PD-1 and PD-L1 drugs for a variety of human cancers. However, only a few studies have evaluated PD-L1 expression in esophageal squamous cell carcinoma (ESCC) with a large Chinese cohort. Our present study is to evaluate the association of PD-L1 expression with clinicopathological features on ESCC. Read More

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http://dx.doi.org/10.1186/s13000-019-0778-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347821PMC
January 2019
15 Reads

Mediastinal follicular dendritic cell sarcoma: a rare, potentially under-recognized, and often misdiagnosed disease.

Diagn Pathol 2019 Jan 15;14(1). Epub 2019 Jan 15.

Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, China.

Background: Mediastinal follicular dendritic cell sarcoma (FDCS) is extremely rare. Due to potential under-recognization of this disease, it happens to be misdiagnosed, especially on core needle biopsy. We report 3 cases of mediastinal FDCS and provide a literature review to improve better understanding of the tumor and to reduce misdiagnosis. Read More

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http://dx.doi.org/10.1186/s13000-019-0779-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334468PMC
January 2019
3 Reads

LPS-induced CXCR7 expression promotes gastric Cancer proliferation and migration via the TLR4/MD-2 pathway.

Diagn Pathol 2019 Jan 12;14(1). Epub 2019 Jan 12.

Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.

Background: Lipopolysaccharide (LPS) from Helicobacter pylori (HP) plays an important role in gastric cancer occurrence and development. Toll-like receptor 4 (TLR4) and myeloid differential protein-2 (MD-2) are also reported to be involved in gastric cancer cell proliferation and invasion. CXC chemokine receptor 7 (CXCR7), a second receptor for CXCL12, has been detected in multiple types of tumor tissues. Read More

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http://dx.doi.org/10.1186/s13000-019-0780-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330400PMC
January 2019
2 Reads

High-grade serous ovarian carcinoma with mucinous differentiation: report of a rare and unique case suggesting transition from the "SET" feature of high-grade serous carcinoma to the "STEM" feature.

Diagn Pathol 2019 Jan 12;14(1). Epub 2019 Jan 12.

Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, 501-1194, Japan.

Background: High-grade serous carcinoma, a representative high-grade ovarian carcinoma, is believed to be closely associated with a TP53 mutation. Recently, this category of ovarian carcinoma has gained increasing attention owing to the recognition of morphological varieties of TP53-mutated high-grade ovarian carcinoma. Herein, we report the case of a patient with high-grade serous carcinoma with mucinous differentiation. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-019-0781-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330567PMC
January 2019
12 Reads

Histological characteristics of the largest and secondary tumors in radical prostatectomy specimens and implications for focal therapy.

Diagn Pathol 2019 Jan 12;14(1). Epub 2019 Jan 12.

Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

Background: Pathological features of prostate cancer in Korean men were analyzed to determine whether identification of tumor volume, Gleason score (GS), focality, and location using radical prostatectomy (RP) specimens can provide useful information for the application of focal therapy (hemiablation).

Methods: From January 2016 to December 2017, 913 patients who underwent RP at a single center were selected for analysis. Patients with prostate-specific antigen levels > 15 ng/mL or those who had received hormone therapy prior to surgery were excluded. Read More

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http://dx.doi.org/10.1186/s13000-019-0782-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330453PMC
January 2019
3 Reads

Gastroesophageal junction Paneth cell carcinoma with extensive cystic and secretory features - case report and literature review.

Diagn Pathol 2019 Jan 8;14(1). Epub 2019 Jan 8.

Department of Pathology, MD Anderson Cancer Center, Houston, USA.

Background: Carcinomas composed predominantly or purely of malignant Paneth cells were rarely reported in gastrointestinal system. They have not been reported at gastroesophageal junction nor has the association with Barrett esophagus been explored. None of the previous studies has mentioned any peculiar histologic features other than typical adenocarcinoma containing neoplastic Paneth cells. Read More

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http://dx.doi.org/10.1186/s13000-018-0775-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323739PMC
January 2019
2 Reads

Droplet digital PCR for the quantification of Alu methylation status in hematological malignancies.

Diagn Pathol 2018 Dec 22;13(1):98. Epub 2018 Dec 22.

Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, P.zza G. Cesare, 11 70124, Bari, Italy.

Background: Alu repeats, belonging to the Short Interspersed Repetitive Elements (SINEs) class, contain about 25% of CpG sites in the human genome. Alu sequences lie in gene-rich regions, so their methylation is an important transcriptional regulation mechanism. Aberrant Alu methylation has been associated with tumor aggressiveness, and also previously discussed in hematological malignancies, by applying different approaches. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-018-0777-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303857PMC
December 2018
19 Reads
2.411 Impact Factor

An autopsy case of epignathus (immature teratoma of the soft palate) with intracranial extension but without brain invasion: case report and literature review.

Diagn Pathol 2018 Dec 22;13(1):99. Epub 2018 Dec 22.

Department of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.

Background: Epignathus is a rare congenital orofacial teratoma infrequently associated with intracranial extension. Intracranial extension of an epignathus indicates a poor prognosis; however, only a small number of such cases have been reported. While there have been some studies reporting cases of epignathus expanding directly into the cranium, others have reported no communication between an epignathus and an intracranial tumor. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-018-0776-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303979PMC
December 2018
15 Reads

Genetic and molecular origins of colorectal Cancer among the Iranians: an update.

Diagn Pathol 2018 Dec 22;13(1):97. Epub 2018 Dec 22.

Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Colorectal cancer (CRC) is one the leading causes of cancer related deaths among Iranians. Despite the various progresses in new therapeutic methods, it has still a low rate of survival. This high ratio of mortality is mainly related to the late diagnosis, in which the patients refer for treatment in advanced stages of tumor. Read More

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http://dx.doi.org/10.1186/s13000-018-0774-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303916PMC
December 2018
1 Read

Dual monoclonal antibody-based sandwich ELISA for detection of in vitro packaged Ebola virus.

Diagn Pathol 2018 Dec 19;13(1):96. Epub 2018 Dec 19.

Hubei Engineering Research Center of Viral Vector, Applied Biotechnology Research Center, Wuhan University of Bioengineering, Wuhan, 430400, China.

Background: Rapid transmission and high mortality of Ebola virus disease (EVD) highlight a urgent need of large scale, convenient and effective measure for Ebola virus screening. Application of monoclonal antibodies (mAbs) are crucial for establishment of an enzyme-linked immunosorbent assay (ELISA) with high sensitivity and specificity.

Methods: The traditional cell fusion technique was used to generate a panel of hybridomas. Read More

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http://dx.doi.org/10.1186/s13000-018-0773-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300876PMC
December 2018
3 Reads

Bacterial outer membrane vesicles, a potential vaccine candidate in interactions with host cells based.

Diagn Pathol 2018 Dec 11;13(1):95. Epub 2018 Dec 11.

Department of Immunology, Jiangsu University, Zhenjiang, 212013, Jiangsu, China.

Both Gram-Positive and Gram-Negative bacteria can secrete outer membrane vesicles (OMVs) in their growth and metabolism process. Originally, OMVs were considered as a by-product of bacterial merisis. However, many scientists have reported the important role of OMVs in many fields recently. Read More

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http://dx.doi.org/10.1186/s13000-018-0768-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290530PMC
December 2018
13 Reads

Tumor-infiltrating CD8+ and FOXP3+ lymphocytes before and after neoadjuvant chemotherapy in cervical cancer.

Diagn Pathol 2018 Nov 24;13(1):93. Epub 2018 Nov 24.

Department of Surgical Pathology, Women's Hospital, School of Medicine, Zhejiang University, Province, Zhejiang, 310006, China.

Background: Neoadjuvant chemotherapy (NACT) has been recently accepted as an effective alternative in patients with locally advanced cervical cancer. However, little is known about the effects of NACT on the immunological microenvironment in cervical cancers. In this study, we analyzed the alterations of tumor infiltrating lymphocytes (TILs) before and after NACT and analyzed their prognostic significance in advanced cervical cancer patients treated with platinum-based NACT. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-018-0770-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260654PMC
November 2018
13 Reads

Erdheim Chester disease in a patient with Burkitt lymphoma: a case report and review of literature.

Diagn Pathol 2018 Nov 24;13(1):94. Epub 2018 Nov 24.

Department of Pathology, The Ohio State University Wexner Medical Center, 410 W. 10th Ave, N#308, Columbus, OH, 43210, USA.

Background: Erdheim Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis characterized by widespread tissue infiltration by CD68-positive, CD1a-negative foamy histiocytes. ECD can be difficult to identify, and diagnosis relies on the presence of histiocytes with certain histologic and immunophenotypic features in an appropriate clinical and radiologic setting. Clinical signs and symptoms are variable depending on which organ systems are involved. Read More

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http://dx.doi.org/10.1186/s13000-018-0772-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260675PMC
November 2018
8 Reads

Rare case of low-grade extranodal NK/T-cell lymphoma, nasal type, arising in the setting of chronic rhinosinusitis and harboring a novel N-terminal KIT mutation.

Diagn Pathol 2018 Nov 23;13(1):92. Epub 2018 Nov 23.

Department of Pathology and Laboratory Medicine, Division of Hematopathology, Hospital of the University of Pennsylvania, 7.018 Gates Pavilion, 3400 Spruce Street, Philadelphia, PA, 19104-4283, USA.

Background: Extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT), is a rare aggressive subtype of non-Hodgkin lymphoma characterized by angioinvasion, angiodestruction, necrosis and strong association with Epstein-Barr virus (EBV). ENKTCL-NT occurs worldwide and is more prevalent in Asian and the Native American populations of Mexico, Central and South America. It represents approximately 10% of all peripheral T-cell lymphomas worldwide. Read More

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http://dx.doi.org/10.1186/s13000-018-0765-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260989PMC
November 2018
4 Reads
2.411 Impact Factor

PD-L1 expression and the prognostic significance in gastric cancer: a retrospective comparison of three PD-L1 antibody clones (SP142, 28-8 and E1L3N).

Diagn Pathol 2018 Nov 21;13(1):91. Epub 2018 Nov 21.

State Key Laboratory of Cancer Biology and Institute of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.

Background: Immunohistochemistry (IHC) for programmed cell death ligand 1 (PD-L1) displays staining diversity. We compared IHC staining of PD-L1 in gastric cancer (GC) by using three commercially available antibody clones, and analyzed the correlation with the prognosis.

Methods: IHC using PD-L1 antibodies (clones SP142, 28-8 and E1L3N) in 315 formalin-fixed paraffin-embedded samples was qualitatively compared at the 1, 5 and 10% cut-off by two pathologists on total, tumor and immune/stromal cells. Read More

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http://dx.doi.org/10.1186/s13000-018-0766-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249875PMC
November 2018
19 Reads
2.411 Impact Factor

Massive Localized Lymphedema in an Unreported Location (Retroperitoneum).

Diagn Pathol 2018 Nov 20;13(1):89. Epub 2018 Nov 20.

Department of Pathology, Koc University School of Medicine, Topkapi / Zeytinburnu, 34010, Istanbul, Turkey.

Background: Massive localized lymphedema (MLL) is a non-neoplastic benign soft tissue lesion that may be confused with sarcomas or other neoplastic proliferations both clinically and morphologically. Most occur in morbidly obese adults on the lower extremities. The objective of this article is to document a case of MLL in the retroperitoneal cavity which is a previously unreported site for this lesion, and to highlight its unusual clinical features. Read More

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http://dx.doi.org/10.1186/s13000-018-0769-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247625PMC
November 2018
15 Reads

Expression of DENDRIN in several glomerular diseases and correlation to pathological parameters and renal failure - preliminary study.

Diagn Pathol 2018 Nov 20;13(1):90. Epub 2018 Nov 20.

Department of Pathology, Forensic medicine and Cytology, University Hospital Centre Split, Split, Croatia.

Background: In glomerular injury dendrin translocates from the slit diaphragm to the podocyte nucleus, inducing apoptosis. We analyzed dendrin expression in IgA glomerulonephritis and Henoch Schönlein purpura (IgAN/HSP) versus in podocytopathies minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), and compared it to pathohistological findings and renal function at the time of biopsy and the last follow-up.

Methods: Twenty males and 13 females with median of age 35 years (min-max: 3-76) who underwent percutaneous renal biopsy and had diagnosis of glomerular disease (GD) were included in this retrospective study. Read More

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http://dx.doi.org/10.1186/s13000-018-0767-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247684PMC
November 2018
52 Reads

Molecular characterization of sessile serrated adenoma/polyps with dysplasia/carcinoma based on immunohistochemistry, next-generation sequencing, and microsatellite instability testing: a case series study.

Diagn Pathol 2018 Nov 20;13(1):88. Epub 2018 Nov 20.

Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.

Background: Colorectal sessile serrated adenoma/polyps (SSA/Ps) are considered early precursor lesions in the serrated neoplasia pathway. Recent studies have shown associations of SSA/Ps with lost MLH1 expression, a CpG island methylator phenotype, and BRAF mutations. However, the molecular biological features of SSA/Ps with early neoplastic progression have not yet been fully elucidated, owing to the rarity of cases of SSA/P with advanced histology such as cytologic dysplasia or invasive carcinoma. Read More

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http://dx.doi.org/10.1186/s13000-018-0771-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247685PMC
November 2018
29 Reads

Overexpression of the recently identified oncogene REDD1 correlates with tumor progression and is an independent unfavorable prognostic factor for ovarian carcinoma.

Diagn Pathol 2018 Nov 14;13(1):87. Epub 2018 Nov 14.

Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, 20032, China.

Background: Regulated in development and DNA damage response (REDD1), a gene responding to hypoxia or multiple DNA damage events, was recently implicated in cancer development and progression. Previously, in vivo and in vitro experiments indicated that REDD1 functions as an oncogene in ovarian cancer cells. However, the role of REDD1 in cancer cell migration and invasion and in clinical significance of prognostic values is not examined in detail. Read More

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http://dx.doi.org/10.1186/s13000-018-0754-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236897PMC
November 2018
25 Reads

Pathological characteristics and genetic features of melanin-producing medullary thyroid carcinoma.

Diagn Pathol 2018 Nov 13;13(1):86. Epub 2018 Nov 13.

Department of Pathology, 150th Hospital of PLA, Luoyang, Henan, 471000, People's Republic of China.

Objective: To study the clinicopathological characteristics and genetic features of melanin-producing medullary thyroid carcinoma (MP-MTC).

Methods: The immunophenotype of MP-MTC was studied using the immunohistochemical method, and its genetic features were assayed using an amplification refractory mutation system or PCR method.

Results: A 71-year-old man presented with a slowly growing 5-cm mass on the left side of the neck for approximately two months. Read More

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http://dx.doi.org/10.1186/s13000-018-0764-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234577PMC
November 2018
3 Reads

MYO18B promotes hepatocellular carcinoma progression by activating PI3K/AKT/mTOR signaling pathway.

Diagn Pathol 2018 Nov 3;13(1):85. Epub 2018 Nov 3.

Department of Infectious Diseases, The Second Affiliated Hospital of Shantou University Medical College, NO. 69 Dongxia North Road, Shantou, 515041, People's Republic of China.

Background: MYO18B has been identified as a novel tumor suppressor gene in several cancers. However, its specific roles in the progression of hepatocellular carcinoma (HCC) has not been well defined.

Methods: We firstly identified the expression and prognostic values of MYO18B in HCC using TCGA cohort and our clinical data. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-018-0763-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215340PMC
November 2018
8 Reads

A case report of infantile cystic nephroblastoma.

Diagn Pathol 2018 Oct 27;13(1):84. Epub 2018 Oct 27.

Department of Pathology and Laboratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan.

Background: Nephroblastoma (NB) is a malignant embryonal neoplasm derived from nephrogenic blastemal cells. NB usually forms a solid mass, but in extremely rare cases, it may show cystic changes.

Case Presentation: A six-month-old girl with persistent high fevers was found to have pyuria and bacteriuria. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-018-0761-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204273PMC
October 2018
25 Reads

Robustness of biomarker determination in breast cancer by RT-qPCR: impact of tumor cell content, DCIS and non-neoplastic breast tissue.

Diagn Pathol 2018 Oct 20;13(1):83. Epub 2018 Oct 20.

Institute of Pathology, Medizin Campus Bodensee, Röntgenstraße 2, 88048, Friedrichshafen, Germany.

Background: Tissue heterogeneity in formalin-fixed paraffin-embedded (FFPE) breast cancer specimens may affect the accuracy of reverse transcription quantitative real-time PCR (RT-qPCR). Herein, we tested the impact of tissue heterogeneity of breast cancer specimen on the RT-qPCR-based gene expression assay MammaTyper®.

Methods: MammaTyper® quantifies the mRNA expression of the four biomarkers ERBB2, ESR1, PGR, and MKI67. Read More

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http://dx.doi.org/10.1186/s13000-018-0760-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195967PMC
October 2018
1 Read

An unusual case report of indolent T-cell lymphoproliferative disorder with aberrant CD20 expression involving the gastrointestinal tract and bone marrow.

Diagn Pathol 2018 Oct 20;13(1):82. Epub 2018 Oct 20.

Department of Pathology, Shenzhen Hospital of Peking University, Lianhua road 1120, Futian district of Shenzhen, Shenzhen, 518036, China.

Background: Indolent T-cell proliferative disorder of the GIT is a rare and provisional entity in the revised WHO 2016 classification. The patients usually have prolonged survival with persistent disease even without any treatment.

Case Presentation: The 46 years old male patient has been followed up for more than 6 years without chemotherapy. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-018-0762-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195681PMC
October 2018
9 Reads

Microfluidics-based immunofluorescence for fast staining of ALK in lung adenocarcinoma.

Diagn Pathol 2018 Oct 16;13(1):79. Epub 2018 Oct 16.

Institute of Pathology and Molecular Pathology, University Hospital Zurich, CH-8091, Zurich, Switzerland.

Background: Anaplastic lymphoma kinase (ALK) is a key oncogenic driver in lung adenocarcinoma patients and its fusion proteins are routinely assessed. The microfluidic tissue processor (MTP) device is based on a chip-confined low-volume technology allowing for rapid immunohistochemistry/immunofluorescence (IHC/IF) stainings of formalin-fixed paraffin-embedded (FFPE) or frozen tissue samples.

Methods: A novel ALK IF protocol was developed for the MTP device using the primary mouse anti-human ALK antibody clone 5A4. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-018-0757-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192181PMC
October 2018
3 Reads

Release of circulating tumor cells and cell-free nucleic acids is an infrequent event in synovial sarcoma: liquid biopsy analysis of 15 patients diagnosed with synovial sarcoma.

Diagn Pathol 2018 Oct 17;13(1):81. Epub 2018 Oct 17.

1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26, Budapest, H-1085, Hungary.

Background: Synovial sarcoma is a rare soft tissue tumor which contains the unique SS18-SSX1, SS18-SSX2 - or, rarely, SS18-SSX4 - fusion transcripts. It is well known that some soft tissue tumors, like Ewing sarcomas and myxoid liposarcomas, can spread via the blood with free circulating tumor cells (CTC); this can be detected by several sensitive molecular biology methods. Here we report a study of fifteen synovial sarcoma patients with varied clinical backgrounds. Read More

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http://dx.doi.org/10.1186/s13000-018-0756-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191904PMC
October 2018
1 Read

Increased expression of heat shock factor 1 (HSF1) is associated with poor survival in gastric cancer patients.

Diagn Pathol 2018 Oct 17;13(1):80. Epub 2018 Oct 17.

Department of Gastrointestinal Surgery, First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Road, Guangzhou, 510080, China.

Background: Heat shock factor 1 (HSF1) was initially identified as a transcription factor encoding heat shock proteins, which assist in refolding or degrading damaged proteins. Recent studies have reported that HSF1 can act as an oncogene that regulates tumour progression. The present study aimed to elucidate the clinicopathological significance and prognostic value of HSF1 expression in gastric cancer (GC). Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s13000-018-0755-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191912PMC
October 2018
17 Reads