Search Our Scientific Publications & Authors

J Intern Med 2021 Jun 12. Epub 2021 Jun 12.

Division of Diagnostics and Specialist Medicine, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.

Non-alcoholic fatty liver disease (NAFLD) is defined by presence of steatosis in more than 5% of liver cells. The gold standard for diagnosis is liver biopsy, but this is seldom achieved due to costs and risk for side-effects, why the diagnosis is mostly made based on a combination of radiology and exclusion of other liver diseases. Disease severity staging can be non-invasively achieved with radiological exams such as elastography, or blood-based markers, that usually have lower sensitivity and specificity. Read More

Eur Radiol 2021 Jun 12. Epub 2021 Jun 12.

Department of Medical and Surgical Sciences - DIMEC, Alma Mater Studiorum - University of Bologna, Bologna, Italy.

Objectives: To evaluate the inter-observer reliability of modified Response Evaluation Criteria In Solid Tumours (mRECIST) of patients with hepatocellular carcinoma (HCC) undergoing neo-adjuvant treatments before liver transplant (LT). The agreement of tumor number, size, transplant criteria, and the radiological-pathological concordance were also assessed.

Methods: A total of 180 radiological studies before/after neo-adjuvant therapies performed on 90 patients prior to LT were reviewed from three expert centers. Read More

Geroscience 2021 Jun 11. Epub 2021 Jun 11.

Advanced Technology Center for Aging Research, IRCCS INRCA, 60121, Ancona, Italy.

Cadmium (Cd) accumulates with aging and is elevated in long-lived species. Metallothioneins (MTs), small cysteine-rich proteins involved in metal homeostasis and Cd detoxification, are known to be related to longevity. However, the relationship between Cd accumulation, the role of MTs, and aging is currently unclear. Read More

Dig Liver Dis 2021 Jun 8. Epub 2021 Jun 8.

Department of Internal Medicine, IRCCS San Matteo Hospital Foundation, University of Pavia, Pavia, Italy. Electronic address:

Background: Eosinophilic oesophagitis (EoE) may lead to severe complications if not promptly recognised.

Aims: To assess the diagnostic delay in patients with EoE and to explore its risk factors.

Methods: EoE patients followed-up at eight clinics were included via retrospective chart review. Read More

Dig Liver Dis 2021 Jun 8. Epub 2021 Jun 8.

Medical-Surgical Department of Clinical Sciences and Translational Medicine, Sant'Andrea Hospital, University Sapienza, Rome, Italy. Electronic address:

Background: In corpus atrophic gastritis (CAG), hypochlorhydria makes plausible the overgrowth of intragastric bacteria, whose role in gastric carcinogenesis is under debate.

Aims: To characterize the antrum/corpus composition of the gastric bacterial microbiota in CAG patients compared to controls without CAG.

Methods: A cross-sectional monocentric study on consecutive patients with known histological diagnosis of CAG undergoing gastroscopy for gastric cancer surveillance and patients without CAG undergoing gastroscopy for dyspepsia or anemia (108 biopsies from 55 patients, median age 61. Read More

Gastroenterology 2021 Jun 8. Epub 2021 Jun 8.

Second Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan.

Background And Aims: Benefit of rapid on-site evaluation (ROSE) on diagnostic accuracy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) has never been evaluated in a randomized study. This trial aimed to test the hypothesis that in solid pancreatic lesions (SPLs), diagnostic accuracy of EUS-FNB without ROSE was not inferior to that of EUS-FNB with ROSE.

Methods: Non-inferiority study (non-inferiority margin 5%) conducted at 14 centers in eight countries. Read More

PLoS One 2021 11;16(6):e0253070. Epub 2021 Jun 11.

Toronto Centre for Liver Disease, University Health Network, Toronto, Canada.

Background And Aims: Immune checkpoint inhibitors (ICI) are increasingly used in cancer therapy. Elevated liver enzymes frequently occur in patients treated with ICI but evaluation is poorly described. We sought to better understand causes of liver enzyme elevation, investigation and management. Read More

Medicine (Baltimore) 2021 Jun;100(23):e25774

Division of Medical Oncology, Department of Medicine, Showa University School of Medicine.

Introduction: Immune checkpoint inhibitors (ICIs), particularly anti-PD-1 antibody, have dramatically changed cancer treatment; however, fatal immune-related adverse events (irAEs) can develop. Here, we describe a severe case of sclerosing cholangitis-like irAE. We report the use of 3 immunosuppressive agents that resulted in the death of the patient due to treatment inefficacy. Read More

J Vet Diagn Invest 2021 Jun 10:10406387211021865. Epub 2021 Jun 10.

Comparative, Diagnostic, and Population Medicine, University of Florida, Gainesville, FL, USA.

Estimation of the postmortem interval (PMI) is a poorly studied field in veterinary pathology. The development of field-applicable methods is needed given that animal cruelty investigations are increasing continually. We evaluated various histologic criteria in equine brain, liver, and muscle tissue to aid the estimation of PMI in horses, which is central to forensic investigations of suspicious death. Read More

Mod Pathol 2021 Jun 9. Epub 2021 Jun 9.

Department of Pathology, Michigan Medicine, Ann Arbor, MI, USA.

Vibration-controlled transient elastography (VCTE) is a non-invasive method of evaluating liver fibrosis and steatosis. It can easily be performed in the outpatient setting and has been suggested as an alternative to liver biopsy. However, VCTE and biopsy discrepancies commonly occur. Read More

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(6):562-570

Department of Gastroenterological Medicine, South-nara General Medical Center.

Contrast medium-enhanced computed tomography revealed a mass in the liver of a 65-year-old man. The edge but not the center of the mass was enhanced. Ultrasonography-guided percutaneous needle biopsy revealed the diagnosis of angiosarcoma of the liver, and it was treated with chemotherapy. Read More

Ann Palliat Med 2021 May;10(5):5509-5519

Clinical Laboratory, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, China.

Background: In consideration of the limitations of liver biopsy, the past years have seen a great advance in the application of noninvasive indices in assessing liver fibrosis. However, the accuracies of the existing indices to determine liver fibrosis in patients with chronic hepatitis B (CHB) are still unsatisfactory. Here, we established a noninvasive diagnostic model for assessing significant liver fibrosis (SLF) in CHB patients based on serum chitinase 3-like 1 (CH3L1) and routine clinical indicators. Read More

Medicine (Baltimore) 2021 May;100(19):e25358

Hainan Medical University, Haikou, Hainan, China.

Background: Nonalcoholic fatty liver disease (NAFLD) includes nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH), which ranks only second to viral hepatitis and poses an increasingly serious challenge to global public health and economy. NAFLD has attracted more and more attention, but there is no drugs with exact curative effects are available. The commonly used drugs for the treatment of NAFLD in clinical practice are statins, such drugs, inevitably increase the burden on the live. Read More

EJNMMI Res 2021 Jun 9;11(1):55. Epub 2021 Jun 9.

Department of Nuclear Medicine, XiangYa Hospital, Central South University, No. 87 XiangYa Road, ChangSha, Hunan Province, People's Republic of China.

Objective: To evaluate the diagnostic efficacy of F-AlF-NOTA-octreotide (F-OC) PET/CT compared with that of Ga-DOTATATE PET/CT.

Materials And Methods: Twenty patients (mean age: 52.65 years, range: 24-70 years) with biopsy-proven neuroendocrine neoplasms (NENs) were enrolled in this prospective study. Read More

Klin Lab Diagn 2021 Jun;66(6):364-370

GBUZ Volgograd Regional Clinical Center for Medical Rehabilitation.

The aim of the work was to assess the possibility of the cytological method in the diagnosis of epithelial liver tumors and to determine the cytomorphological criteria in the differential diagnosis of liver carcinomas. The authors analyzed the data of 106 fine-needle aspiration biopsies and 167 smears-prints during cor-biopsy of masses of the liver in patients who were examined at the polyclinic of the oncological dispensary in Nizhny Novgorod in 2016. - 2017 As a result, full-fledged material for cytological examination in the form of smears-prints from cor-biopsy and fine-needle aspiration biopsies was obtained in 75. Read More

Hepatology 2021 Jun 9. Epub 2021 Jun 9.

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan.

Background And Aims: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. Nonalcoholic steatohepatitis (NASH), the progressive form of NAFLD, and advanced fibrosis are associated with poor outcomes. We searched for their noninvasive biomarkers. Read More

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun;29(3):735-740

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730,

Objective: To investigate the clinical characteristics of patients with extranodal NK/T-cell lymphoma (ENKL), and to analyze the factors that affecting the survival and prognostic of patients treated with pegaspargase based chemotherapy.

Methods: The clinical data of 61 ENKL patients treated in Peking Union Medical College Hospital from January 2015 to June 2019 were enrolled and retrospectively analyzed. The clinical characteristics, survival rate and influencing factors of prognostic in patients were investigated. Read More

Cureus 2021 May 6;13(5):e14880. Epub 2021 May 6.

Department of Medicine, Lady Hardinge Medical College, Delhi, IND.

Immune hemolytic anemia is very rarely associated with chronic liver disease. Diagnosis is often complicated in critically ill patients, where an etiological diagnosis can be elusive, especially in routine health care settings. A 48-year-old man presented with jaundice for three months. Read More

Pak J Med Sci 2021 May-Jun;37(3):680-683

Dr. Usman Iqbal Aujla, Consultant Gastroenterologist , Pakistan Kidney and Liver Institute & Research Centre, Lahore, Pakistan.

Background And Objectives: Chronic liver disease (CLD) in children present a broad spectrum of symptoms. Limited resources in Paediatric Hepatology in developing countries like Pakistan present considerable challenges in investigating and treating children with chronic liver disease in a timely fashion. This study aimed to determine the spectrum and outcomes of CLD other than chronic hep B & C virus (HBV& HCV) liver disease in children. Read More

Turkiye Parazitol Derg 2021 06;45(2):146-148

University Hospital Centre Zagreb Faculty of Medicine, Department of Surgery, Zagreb, Croatia

A 65-year-old man, with signs of acute colon obstruction, was diagnosed with rectal tumour and liver hydatid cyst. Additionally, a focal liver lesion in segment 1 was detected. Moreover, physical examination revealed hepatomegaly and abdominal distension. Read More

Zhonghua Wai Ke Za Zhi 2021 Jun;59(6):401-421

Department of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730,China.

Pancreatic neuroendocrine neoplasms (pNENs) are highly heterogeneous, and the management of pNENs patients can be intractable. To address this challenge, an expert committee was established on behalf of the Group of Pancreatic Surgery, Chinese Society of Surgery, Chinese Medical Association, which consisted of surgical oncologists, gastroenterologists, medical oncologists, endocrinologists, radiologists, pathologists, and nuclear medicine specialists. By reviewing the important issues regarding the diagnosis and treatment of pNENs, the committee concluded evidence-based statements and recommendations in this article, in order to further improve the management of pNENs patients in China. Read More

Hum Pathol 2021 Jun 5. Epub 2021 Jun 5.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

To evaluate cytokeratin 19 expression in normal and cancerous tissues, 15,977 samples from 122 tumor types and 608 samples of 76 normal tissue types were analyzed by immunohistochemistry. In normal tissues, CK19 expression occurred in epithelial cells of most glandular organs but was strictly limited to the basal cell layer of non-keratinizing squamous epithelium and absent in the skin. CK19 expression in ≥90% of cases was seen in 34% of the tumor entities including the adenocarcinomas of the pancreas (99. Read More

J Turk Ger Gynecol Assoc 2021 Jun 8. Epub 2021 Jun 8.

Department of Gynecology Oncology, Hospital Puerta de Hierro, Madrid, Spain.

Objective: The diagnosis of endometrial cancer is made by biopsy sampling with pathological analysis, but it is extremely important to make an accurate diagnosis in order to plan the specific treatment, and we suggest that HE4 in the endometrial tissue and in serum could be tools to make the diagnosis more precise.

Material And Methods: Our prospective study compared patients with endometrial cancer against non-endometrial cancer ones, matched with several variables. The inclusion criteria were females older than 18 years old that accepted to participate in the research study but that had never underwent surgery for other oncological pathologies, whether for ovarian, colon, cervical carcinoma or uterine sarcoma, and none of them had received preoperative chemo or radiotherapy; moreover, they could not have any severe renal or liver pathology. Read More

J Int Med Res 2021 Jun;49(6):3000605211012209

Department of Hepatobiliary Surgery, National Clinical Research Center for Cancer Hospital, Beijing, China.

Background: Although the National Comprehensive Cancer Network guidelines recommend routine lymph node dissection (LND) in intrahepatic cholangiocarcinoma (ICC), the role of LND remains controversial, and the node (N) stage is oversimplified.

Methods: Patients were identified from the Surveillance, Epidemiology, and End Results research data 18 (SEER 18). Propensity score matching (PSM) was used to reduce bias, and Kaplan-Meier curves and Cox proportional hazards models were used to compare overall survival (OS). Read More

Clin Mol Hepatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.

The clinical phenotypes of nonalcoholic fatty liver disease (NAFLD) encompass from simple steatosis to nonalcoholic steatohepatitis (NASH) with varying degrees of fibrosis or cirrhosis. Liver biopsy has been the standard to diagnose NASH. However, there has been strong need for precise and accurate noninvasive tests because of invasiveness and sampling variability of biopsy. Read More

Pathol Res Pract 2021 May 24;224:153490. Epub 2021 May 24.

Department of Pathology, the First Medical Center of the Chinese People's Liberation Army (PLA) General Hospital, Beijing, 100083, China. Electronic address:

Purpose: To explore the clinicopathological features of sclerosing angiomatoid nodular transformation (SANT) of the spleen.

Methods: The clinicopathological data of 26 SANT patients were analyzed.

Result: There were 15 men and 11 women, aged 23-62 years (mean: 43. Read More

Schweiz Arch Tierheilkd 2021 Jun;163(6):397-408

Tierarztpraxis Zettlitz, 09306 Zettlitz, Deutschland.

Introduction: Clinical symptoms are mostly unspecific in hepatic diseases, thus most clinical examinations are of limited benefit in the diagnosis of hepatic diseases and often only general statements can be made about parenchymal damage or loss of function. In contrast, sonography of the liver can provide information about the type of lesion and thus also about the prognosis for the animal. A systematic assessment of organ size, parenchymal, vascular and bile duct system structures can facilitate to make possible findings. Read More

Ultrasound Obstet Gynecol 2021 Jun 7. Epub 2021 Jun 7.

Department of Obstetrics and Gynaecology, Division of Obstetrics and Fetomaternal Medicine, Medical University of Vienna, Austria.

Objectives: Heterotaxy or isomerism of the atrial appendages, is defined as an abnormal arrangement of inner organs across the left-right axis of the heart. Left-atrial isomerism (LAI) is frequently associated with fetal arrhythmia and two-ventricle congenital heart disease (CHD), whereas right-atrial isomerism (RAI) is typically associated with more complex CHD. Both LAI and RAI can exhibit various non-cardiac anomalies with serious impact on fetal outcome. Read More

Methods Mol Biol 2021 ;2310:69-77

Department of Pathomorphology, The Children's Memorial Health Institute, Warsaw, Poland.

Investigation of mitochondrial metabolism perturbations and successful diagnosis of patients with mitochondrial abnormalities often requires assessment of human samples like muscle or liver biopsy as well as autopsy material. Immunohistochemical and histochemical examination is an important technique to investigate mitochondrial dysfunction that combined with spectrophotometric and Blue Native electrophoresis techniques can be an important tool to provide diagnosis of mitochondrial disorders. In this chapter, we focus on technical description of the methods that are suitable to detect the activity of complex I, II, and IV of mitochondrial respiratory chain in frozen sections of brain, heart, muscle, and liver biopsies/autopsy. Read More

Gastric Cancer 2021 Jun 6. Epub 2021 Jun 6.

Department of Surgical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.

Background: Gastric cancer (GC) is one of the leading causes of cancer deaths with high heterogeneity. There is currently a paucity of clinically applicable molecular classification system to guide precise medicine.

Methods: A total of 70 Chinese patients with GC were included in this study and whole-exome sequencing was performed. Read More