166,015 results match your criteria Diagnostic Liver Biopsy


A novel approach for the forensic diagnosis of drowning by microbiological analysis with next-generation sequencing and unweighted UniFrac-based PCoA.

Int J Legal Med 2020 Jul 2. Epub 2020 Jul 2.

Department of Forensic Pathology, China Medical University School of Forensic Medicine, Shenyang, China.

The diagnosis of drowning is one of the major challenges in forensic practice, especially when the corpse is in a state of decomposition. Novel indicators of drowning are desired in the field of forensic medicine. In the past decade, aquatic bacteria have attracted great attention from forensic experts because they can easily enter the blood circulation with drowning medium, and some of them can proliferate in the corpse. Read More

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http://dx.doi.org/10.1007/s00414-020-02358-1DOI Listing

EUS-guided fine-needle core liver biopsy with a modified one-pass, one-actuation wet suction technique comparing two types of EUS core needles.

Endosc Int Open 2020 Jul 16;8(7):E938-E943. Epub 2020 Jun 16.

University of Utah School of Medicine Huntsman Cancer Center - Gastroenterology and Hepatology, Salt Lake City, Utah, United States.

We compared the diagnostic yield and specimen adequacy in EUS-guided parenchymal biopsies between two types of EUS 19 G core needles. This is a retrospective study of 420 patients at two tertiary medical centers in Florida with unexplained abnormal liver associated tests were referred for EUS evaluation of biliary obstruction and pancreatic pathology. EUS-guided liver biopsy (EUS-LB) was performed at the same session after biliary obstruction was excluded. Read More

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http://dx.doi.org/10.1055/a-1165-1767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297611PMC

Autoantibody signature in hepatocellular carcinoma using seromics.

J Hematol Oncol 2020 Jul 2;13(1):85. Epub 2020 Jul 2.

Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, China.

Background: Alpha-fetoprotein (AFP) is a widely used biomarker for hepatocellular carcinoma (HCC) early detection. However, low sensitivity and false negativity of AFP raise the requirement of more effective early diagnostic approaches for HCC.

Methods: We employed a three-phase strategy to identify serum autoantibody (AAb) signature for HCC early diagnosis using protein array-based approach. Read More

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http://dx.doi.org/10.1186/s13045-020-00918-xDOI Listing

The macrophage activation marker soluble CD163 is elevated and associated with liver disease phenotype in patients with Wilson's disease.

Orphanet J Rare Dis 2020 Jul 2;15(1):173. Epub 2020 Jul 2.

Department of Hepatology and Gastroenterology, Aarhus University Hospital, 99 Palle Juul-Jensens Boulevard, DK-8200, Aarhus N, Denmark.

Background: Macrophages play a significant role in liver disease development and progression. The macrophage activation marker soluble (s)CD163 is associated with severity and prognosis in a number of different acute and chronic liver diseases but has been only sparsely examined in Wilson's disease (WD). We investigated sCD163 levels in patients with acute and chronic WD and hypothesized associations with liver disease phenotype and biochemical markers of liver injury. Read More

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http://dx.doi.org/10.1186/s13023-020-01452-2DOI Listing

Histopathological findings in a COVID-19 patient affected by ischemic gangrenous cholecystitis.

World J Emerg Surg 2020 Jul 2;15(1):43. Epub 2020 Jul 2.

Digestive Surgery Unit, Department of Science of Health, "Magna Graecia" University, Catanzaro, Italy.

Background: Since its first documentation, a novel coronavirus (SARS-CoV-2) infection has emerged worldwide, with the consequent declaration of a pandemic disease (COVID-19). Severe forms of acute respiratory failure can develop. In addition, SARS-CoV-2 may affect organs other than the lung, such as the liver, with frequent onset of late cholestasis. Read More

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http://dx.doi.org/10.1186/s13017-020-00320-5DOI Listing

Noninvasive Evaluation of Nonalcoholic Fatty Liver Disease.

Authors:
Dae Ho Lee

Endocrinol Metab (Seoul) 2020 Jun 24;35(2):243-259. Epub 2020 Jun 24.

Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.

Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver diseases and can progress to advanced fibrosis and end-stage liver disease. Thus, intensive research has been performed to develop noninvasive methods for the diagnosis of nonalcoholic steatohepatitis (NASH) and fibrosis. Currently, no single noninvasive tool covers all of the stages of pathologies and conditions of NAFLD, and the cost and feasibility of known techniques are also important issues. Read More

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http://dx.doi.org/10.3803/EnM.2020.35.2.243DOI Listing

[Hepatolienal candidosis as a rare differential diagnosis of disseminated small parenchym lesions].

Dtsch Med Wochenschr 2020 Jul 2;145(13):912-916. Epub 2020 Jul 2.

Klinik für Diagnostische und Interventionelle Radiologie, Uniklinikum Ulm, Ulm.

History:  We report about a 17-year-old patient with the secondary malignancy of acute myeloid leukemia (AML). He developed fever of unclear origin during the hematopoietic stem cell transplantation.History We report about a 17-year-old patient with the secondary malignancy of acute myeloid leukemia (AML). Read More

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http://dx.doi.org/10.1055/a-1164-0043DOI Listing

Development and validation of a combined enzymatic-digestion/mass spectrometry assay for Tacrolimus quantitation in cardiac biopsies.

J Chromatogr B Analyt Technol Biomed Life Sci 2020 Jun 21;1152:122215. Epub 2020 Jun 21.

Clinical and Experimental Pharmacokinetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. Electronic address:

Recent studies report strategies for analysing immunosuppressive drugs in brain, liver and renal tissue, mostly in animals: we developed and validated a two steps combined enzymatic digestion/mass spectrometry assay to quantify Tacrolimus (TAC) in heart biopsies. Our aims were to avoid sample loss and sample contamination during the laboratory preparation, and to limit matrix effects in the electrospray ionization source (ESI) of the mass spectrometer. Enzymatic tissue digestion followed by a liquid-liquid drug extraction in the same vial of reaction allowed us to reach both our aims. Read More

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http://dx.doi.org/10.1016/j.jchromb.2020.122215DOI Listing

MicroRNAs 155-5p, 122-5p and 181a-5p identify patients with graft dysfunction due to T-cell mediated rejection after liver transplantation.

Liver Transpl 2020 Jul 2. Epub 2020 Jul 2.

Liver Transplant Unit, Hospital Clínic Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERehd, University of Barcelona, Barcelona, Spain.

MicroRNAs (miRNAs) are small non-coding RNAs that can be detected in plasma and whose expression is associated with pathological processes. The role of miRNAs in the non-invasive diagnosis of T-cell mediated rejection (TCMR) after liver transplantation is unclear. Thus, we aimed to assess the effectiveness of a panel of four miRNAs (155-5p, 122-5p, 181a-5p and 148-3p) in diagnosing TCMR in liver transplant recipients with graft dysfunction (GD), and compare its accuracy with previously published tests for diagnosing TCMR based on routine laboratory parameters. Read More

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http://dx.doi.org/10.1002/lt.25842DOI Listing

Evaluation of circulating tumor DNA as a biomarker in pancreatic cancer with liver metastasis.

PLoS One 2020 2;15(7):e0235623. Epub 2020 Jul 2.

Project of Development of Liquid Biopsy Diagnosis, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan.

Pancreatic cancer is an aggressive, solid tumor, with a grave prognosis. Despite surgical treatment in patients with pancreatic cancer, the rate of recurrence is high. In addition, although tumor biomarkers are frequently used to confirm advanced pancreatic cancer, this is not accurate and the biomarkers currently used cannot indicate prognosis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235623PLOS

Synergistic effects of extracellular vesicle phenotyping and AFP in hepatobiliary cancer differentiation.

Liver Int 2020 Jul 2. Epub 2020 Jul 2.

Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany.

Background: Biliary cancer, comprising cholangio- and gallbladder carcinomas, is associated with high mortality due to asymptomatic disease onset and resulting late diagnosis. Currently, no robust diagnostic biomarker is clinically available. Therefore, we explored the feasibility of extracellular vesicles (EVs) as a liquid biopsy tool for biliary cancer screening and hepatobiliary cancer differentiation. Read More

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http://dx.doi.org/10.1111/liv.14585DOI Listing

Skull Metastasis From Uterine Leiomyosarcoma, a Rare Presentation for a Rare Tumor: A Case Report and Review of the Literature.

Front Oncol 2020 16;10:869. Epub 2020 Jun 16.

Medical Oncology Unit, S.Orsola-Malpighi University Hospital, Bologna, Italy.

Uterine leiomyosarcoma (uLMS) is a rare and aggressive malignancy with poor clinical outcomes. Even when localized, uLMS is associated with high rates of local and distant recurrences that are usually fatal. Common sites of recurrence are lung, liver, pelvic lymph nodes, and vertebral and long bones, though atypical patterns of recurrence have been described. Read More

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http://dx.doi.org/10.3389/fonc.2020.00869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308452PMC

Undifferentiated Embryonal Sarcoma of the Liver Identified after the Initial Diagnosis of a Hepatic Cyst: A Case Report.

Intern Med 2020 Jun 30. Epub 2020 Jun 30.

Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Japan.

Abdominal ultrasound in a 50-year-old Japanese man revealed a cystic lesion on the caudate lobe of the liver. Four-month follow-up imaging showed a rapid increase in the size of the cystic lesion. The patient underwent laparoscopic partial hepatectomy because of a suspicion and perceived risk that the lesion might be malignant. Read More

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http://dx.doi.org/10.2169/internalmedicine.4853-20DOI Listing

International prospective observational study investigating the disease course and heterogeneity of paediatric-onset inflammatory bowel disease: the protocol of the PIBD-SETQuality inception cohort study.

BMJ Open 2020 Jul 1;10(7):e035538. Epub 2020 Jul 1.

Department of Paediatric Gastroenterology, Erasmus University Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands

Introduction: Patients with paediatric-onset inflammatory bowel disease (PIBD) may develop a complicated disease course, including growth failure, bowel resection at young age and treatment-related adverse events, all of which can have significant and lasting effects on the patient's development and quality of life. Unfortunately, we are still not able to fully explain the heterogeneity between patients and their disease course and predict which patients will respond to certain therapies or are most at risk of developing a more complicated disease course. To investigate this, large prospective studies with long-term follow-up are needed. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035538DOI Listing

A case of Turcot's syndrome type 1 with loss of immunoexpression of MSH6 in colon cancer and liver metastasis due to secondary somatic mutation in coding mononucleotide (C)8 tract: a case report.

BMC Med Genet 2020 Jul 1;21(1):141. Epub 2020 Jul 1.

Department of Surgery, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, 3-1, Aoyama-cho, Kure City, Hiroshima, 737-0023, Japan.

Background: Lynch syndrome (LS), which is known as a hereditary cancer syndrome, is distinguished by microsatellite instability, represented by the altered number of repetitive sequences in the coding and/or non-coding region. Immunohistochemical staining (IHC) of DNA mismatch repair (MMR) proteins (e.g. Read More

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http://dx.doi.org/10.1186/s12881-020-01079-xDOI Listing

Role of Extracellular Vesicles in the Pathophysiology, Diagnosis and Tracking of Non-Alcoholic Fatty Liver Disease.

J Clin Med 2020 Jun 29;9(7). Epub 2020 Jun 29.

College of Medicine and Public Health, Flinders University, Adelaide SA 5042, Australia.

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, affecting approximately one-third of the global population. Most affected individuals experience only simple steatosis-an accumulation of fat in the liver-but a proportion of these patients will progress to the more severe form of the disease, non-alcoholic steatohepatitis (NASH), which enhances the risk of cirrhosis and hepatocellular carcinoma. Diagnostic approaches to NAFLD are currently limited in accuracy and efficiency; and liver biopsy remains the only reliable way to confirm NASH. Read More

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http://dx.doi.org/10.3390/jcm9072032DOI Listing

[Establishment and clinical testing of pancreatic cancer Faster R-CNN AI system based on fast regional convolutional neural network].

Zhonghua Wai Ke Za Zhi 2020 Jul;58(7):520-524

Department of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, Qingdao 266000, China.

To investigate the effectiveness of an enhanced CT automatic recognition system based on Faster R-CNN for pancreatic cancer and its clinical value. In this study, 4 024 enhanced CT imaging sequences of 315 patients with pancreatic cancer from January 2013 to May 2016 at the Affiliated Hospital of Qingdao University were collected retrospectively, and 2 614 imaging sequences were input into the faster R-CNN system as training dataset to create an automatic image recognition model, which was then validated by reading 1 410 enhanced CT images of 135 cases of pancreatic cancer.In order to identify its effectiveness, 3 750 CT images of 150 patients with pancreatic lesions were read and a followed-up was carried out. Read More

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http://dx.doi.org/10.3760/cma.j.cn112139-20191017-00515DOI Listing

[The diagnostic value of three copper staining methods in copper storage disorders of liver disease].

Zhonghua Bing Li Xue Za Zhi 2020 Jul;49(7):741-743

Department of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.

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http://dx.doi.org/10.3760/cma.j.cn112151-20191108-00724DOI Listing

[Metastatic gastrointestinal hepatoid adenocarcinoma of the liver: a high-grade carcinoma that is easily confused with primary hepatocellular carcinoma].

Zhonghua Bing Li Xue Za Zhi 2020 Jul;49(7):710-714

Department of Pathology, the Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China; Department of Pathology, Drum Tower School of Clinical Medicine, Nanjing Medical University, Nanjing 210008, China.

To investigate the clinicopathologic and immunophenotypic features of metastatic gastrointestinal hepatoid adenocarcinomas in the liver. Eight cases of hepatic metastatic gastrointestinal hepatoid adenocarcinoma diagnosed at the Affiliated Drum Tower Hospital, Nanjing University Medical School from January 2009 to January 2019 were retrospectively analyzed. The clinical data, histopathologic features and immunohistochemical (IHC) characteristics performed by EnVision method were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20191123-00753DOI Listing

Suboptimal reliability of liver biopsy evaluation has implications for randomized clinical trials.

J Hepatol 2020 Jun 28. Epub 2020 Jun 28.

Cirius Therapeutics, Inc., San Diego, CA, USA.

Background & Aims: Liver biopsies are a critical component of pivotal studies in nonalcoholic steatohepatitis (NASH) constituting main inclusion criteria, risk stratification factors and endpoints. We evaluated the reliability of NASH Clinical Research Network scoring of liver biopsies in a NASH clinical trial.

Methods: Digitized slides from 678 biopsies for 339 patients with paired biopsies randomized into the EMMINENCE study examining a novel insulin sensitizer (MSDC-0602K) in NASH were read independently by three hepatopathologists blinded to treatment code and scored using the NASH CRN Histological Scoring System. Read More

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http://dx.doi.org/10.1016/j.jhep.2020.06.025DOI Listing

Accurate assessment of nonalcoholic fatty liver disease lesions in liver allograft biopsies by a smartphone platform: A proof of concept.

Microsc Res Tech 2020 Jul 1. Epub 2020 Jul 1.

Department of Pathology, CHU de Nice, Nice, France.

Macrovesicular steatosis (MS) is a major risk factor for liver graft failure after transplantation and pathological microscopic examination of a frozen tissue section remains the gold standard for its assessment. However, the latter requires an experienced in-house pathologist for correct and rapid diagnosis as well as specific equipment that is not always available. Smartphones, which are must-have tools for everyone, are very suitable for incorporation into promising technology to generate moveable diagnostic tools as for telepathology. Read More

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http://dx.doi.org/10.1002/jemt.23478DOI Listing

Sustained Remission After Treatment Withdrawal in Autoimmune Hepatitis: A Multicenter Retrospective Study.

Dig Dis Sci 2020 Jun 30. Epub 2020 Jun 30.

Department of Hepato-Gastroenterology and Digestive Oncology, Reims University Hospital, 51092, Reims, France.

Background: In patients with autoimmune hepatitis (AIH), relapse rates between 25 and 100% after treatment withdrawal have been reported. The optimal strategy for immunosuppressive treatment withdrawal is controversial.

Aim: To identify the predictive factors of histological remission and to assess the relapse rate after treatment withdrawal in AIH patients with prolonged biochemical response. Read More

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http://dx.doi.org/10.1007/s10620-020-06444-7DOI Listing

Late-onset MADD: a rare cause of cirrhosis and acute liver failure?

Acta Myol 2020 Mar 1;39(1):19-23. Epub 2020 Mar 1.

Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Late-onset multiple acyl-CoA dehydrogenase deficiency (MADD) is a severe inborn error of fat metabolism. In late-onset MADD, hepatopathy in the form of steatosis is commonplace and considered a benign and stable condition that does not progress to more advanced stages of liver disease, however, progression to cirrhosis and acute liver failure (ALF) has been reported in two previous case reports. Here, we report a 22-year-old man, who suffered from late-onset MADD and died from cirrhosis and ALF. Read More

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http://dx.doi.org/10.36185/2532-1900-003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315895PMC

Comprehensive treatment of rare multiple endocrine neoplasia type 1: A case report.

World J Clin Cases 2020 Jun;8(12):2647-2654

Department of Hepatobiliary, Hebei General Hospital, Shijiazhuang 050017, Hebei Province, China.

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary disorder caused by mutations of the gene. It is characterized by hyperparathyroidism and involves the pancreas, anterior pituitary, duodenum, and adrenal gland. Here, we report a 40-year-old male patient with MEN1 who first manifested as thymic carcinoid, then primary hyperparathyroidism and prolactinoma, and a decade later pancreatic neuroendocrine tumor. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i12.2647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322426PMC

Cholangiocarcinoma 2020: the next horizon in mechanisms and management.

Nat Rev Gastroenterol Hepatol 2020 Jun 30. Epub 2020 Jun 30.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant tumours that can arise at any point of the biliary tree. Their incidence is increasing globally, currently accounting for ~15% of all primary liver cancers and ~3% of gastrointestinal malignancies. The silent presentation of these tumours combined with their highly aggressive nature and refractoriness to chemotherapy contribute to their alarming mortality, representing ~2% of all cancer-related deaths worldwide yearly. Read More

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http://dx.doi.org/10.1038/s41575-020-0310-zDOI Listing

Incidental hepatic tuberculosis during planned resection of locally advanced ampullary carcinoma: a case report.

BMC Surg 2020 Jun 30;20(1):145. Epub 2020 Jun 30.

Department of Surgery, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia.

Background: Tuberculosis (TB) is classified according to the site of disease as pulmonary or extrapulmonary. Extrapulmonary TB is less common than its counterpart in which it can be found anywhere in the body including the liver. Similar to ampullary carcinoma, TB liver can manifest with jaundice and deranged liver function tests, particularly in the obstructed biliary systems. Read More

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http://dx.doi.org/10.1186/s12893-020-00806-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325297PMC
June 2020
1.240 Impact Factor

[Comparative analysis of bile acid spectrum in non-alcoholic fatty liver disease and cholelithiasis].

Ter Arkh 2019 Feb 15;91(2):48-51. Epub 2019 Feb 15.

Izhevsk State Medical Academy of the Ministry of Health of the Russian Federation.

Aim: Сomparative studying of changes in the spectrum of bile acids in bile in patients with nonalcoholic fatty liver disease and cholelithiasis.

Materials And Methods: 140 patients were included in the survey: 50 - with nonalcoholic fatty liver disease and 90 - with cholelithiasis. The diagnosis of nonalcoholic fatty liver disease was established on the basis of ultrasound examination of the liver, the elasticity and fibrosis of liver by using the sonoelastography and liver biopsy. Read More

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http://dx.doi.org/10.26442/00403660.2019.02.000105DOI Listing
February 2019

Sarcoidosis with Hepatic Involvement: A Case Report.

Sisli Etfal Hastan Tip Bul 2018 30;52(1):54-56. Epub 2018 Mar 30.

Department of Gastroenterology, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, Turkey.

Sarcoidosis is a systemic, noncaseating granulomatous disease with an unknown etiology. The liver is one of the most frequently affected organs. This case is presented to emphasize that hepatic granulomatous foci can lead to a determination of etiology in a diagnosis of sarcoidosis. Read More

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http://dx.doi.org/10.14744/SEMB.2017.76598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315081PMC

Successful use of transarterial radioembolization with yttrium-90 (TARE-Y90) in two children with hepatoblastoma.

Pediatr Blood Cancer 2020 Jun 30:e28421. Epub 2020 Jun 30.

Division of Hematology/Oncology and Bone Marrow Transplantation, Nemours Children's, Specialty Care and Wolfson Children's Hospital, Jacksonville, Florida.

Primary malignant liver tumors are rare but all require surgical resection as part of therapy with curative intent. A minority of patients have resectable tumors at diagnosis. Chemotherapy has a therapeutic role in hepatoblastoma but only one-third of patients have resectable disease at diagnosis. Read More

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http://dx.doi.org/10.1002/pbc.28421DOI Listing

An Unusual Finding on Endoscopy… A Diagnosis of Inclusion?

Transpl Infect Dis 2020 Jun 30:e13393. Epub 2020 Jun 30.

Icahn School of Medicine at Mount Sinai, Division of Liver Diseases, New York, NY, USA.

A 58-year-old male with a history of chronic hepatitis B virus (HBV) infection, hepatocellular carcinoma, and end-stage renal disease underwent a combined liver and kidney transplant. His hepatocellular carcinoma was diagnosed six months prior to his transplant and was treated with trans-arterial chemoembolization (TACE). His chronic hepatitis B was treated with tenofovir disoproxil fumarate with suppressed HBV viral loads. Read More

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http://dx.doi.org/10.1111/tid.13393DOI Listing

Multiple myeloma with hepatic amyloid light-chain amyloidosis manifesting as progressive liver failure.

BMJ Case Rep 2020 Jun 29;13(6). Epub 2020 Jun 29.

Pathology, University of Florida Health at Jacksonville, Jacksonville, Florida, USA.

We present a case of a 45-year-old man admitted to the hospital with new-onset ascites and bilateral subconjunctival haemorrhages. He was found to have elevated liver enzymes in a hepatocellular pattern and direct hyperbilirubinemia. A diagnostic paracentesis was consistent with portal hypertension (PH). Read More

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http://dx.doi.org/10.1136/bcr-2020-234637DOI Listing

Early microscopic findings in preclinical inflammatory bowel disease.

Dig Liver Dis 2020 Jun 26. Epub 2020 Jun 26.

Gastroenterology Department, Hospital Clínico Universitario de Santiago de Compostela, Rúa Choupana, 15706 Santiago de Compostela (Galicia), Spain.

Background: The immune response involved in the pathogenesis of Inflammatory Bowel Disease (IBD) may be present years before the diagnosis, but the characteristics of the disease during the preclinical period have been scarcely investigated.

Aim: To describe the microscopic findings of preclinical IBD and its relationship with the natural history of the disease.

Methods: Medical records from all patients with an incidental diagnosis of IBD during a screening colonoscopy were included in this multicentric and retrospective study. Read More

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http://dx.doi.org/10.1016/j.dld.2020.05.052DOI Listing

[Platypnea: оne more type position shortness of breath].

Ter Arkh 2020 Apr 27;92(3):92-97. Epub 2020 Apr 27.

Sechenov First Moscow State Medical University (Sechenov University).

The article presents modern data on the causes of platypnea, methods of its diagnosis and treatment. The data on the development of platypnea syndrome are given not only in cardiac pathology, but also in severe liver diseases with the development of hepatopulmonary syndrome and chronic obstructive pulmonary disease of a severe course. Read More

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http://dx.doi.org/10.26442/00403660.2020.03.000436DOI Listing

[Сlinical, immunological and morphological features in different types of autoimmune hepatitis].

Ter Arkh 2020 Apr 27;92(2):43-47. Epub 2020 Apr 27.

Loginov Moscow Clinical Scientific and Practical Center.

Due to the absence of the pathognomonic diagnostic criteria and to the diversity of clinical, serological and morphological manifestations, the diagnostic of the autoimmune hepatitis (AIH) remains to be a difficult task, which might lead to the delay of the timely beginning of the immunosuppressive therapy (IST), which in turn affects the disease outcomes.

Aim: To studying the clinical, biochemical, immunological and morphological markers in patients with seronegative (SN) and seropositive (SP) AIH and the qualities of their response to the IST.

Materials And Methods: This retrospective cohort study included 82 AIH patients over the course of the years 20142019. Read More

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http://dx.doi.org/10.26442/00403660.2020.02.000536DOI Listing

[Evaluation of the effectiveness of ultrasound shear elastography and liver steatometry].

Ter Arkh 2020 May 19;92(4):17-22. Epub 2020 May 19.

Рeoples' Friendship University of Russia.

Detection of liver fibrosis and steatosis at early stages is a difficult task for clinical practice, due to the lack of early signs in routine radiation diagnostics.

Aim: To evaluate the efficacy of ultrasound shear elastography and ultrasound steatometry of the liver with the use of domestic ultrasonic diagnostic system Angiodin-Sono/N-Ultra.

Materials And Methods: 264 people held ultrasound elastography and ultrasound steatometry. Read More

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http://dx.doi.org/10.26442/00403660.2020.04.000497DOI Listing

A Novel Diagnostic Nomogram for Noninvasive Evaluating Liver Fibrosis in Patients with Chronic Hepatitis B Virus Infection.

Biomed Res Int 2020 2;2020:5218930. Epub 2020 Jun 2.

Center of Liver Disease, Beijing Ditan Hospital Capital Medical University, Beijing 100015, China.

Objective: To establish a novel nomogram for diagnosing liver fibrosis in patients with chronic hepatitis B virus (HBV) infection and verify the diagnostic performance of the established nomogram.

Methods: Patients with chronic HBV infection who met the inclusion and exclusion criteria were enrolled in this retrospective study; 70% and 30% of patients were randomly assigned to training dataset and validation dataset, respectively. The risk factors for liver fibrosis were screened using the univariate and multivariate logistic regression analyses. Read More

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http://dx.doi.org/10.1155/2020/5218930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290880PMC

Involvement of digestive system in COVID-19: manifestations, pathology, management and challenges.

Therap Adv Gastroenterol 2020 18;13:1756284820934626. Epub 2020 Jun 18.

State Key Laboratory of Cancer Biology & Institute of Digestive Diseases, Xijing Hospital, Air Force Medical University, Changle West Road 127, Xi'an, Shaanxi, 710032, China.

The pandemic of novel coronavirus disease (COVID-19) has developed as a tremendous threat to global health. Although most COVID-19 patients present with respiratory symptoms, some present with gastrointestinal (GI) symptoms like diarrhoea, loss of appetite, nausea/vomiting and abdominal pain as the major complaints. These features may be attributable to the following facts: (a) COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and its receptor angiotensin converting enzyme 2 (ACE2) was found to be highly expressed in GI epithelial cells, providing a prerequisite for SARS-CoV-2 infection; (b) SARS-CoV-2 viral RNA has been found in stool specimens of infected patients, and 20% of patients showed prolonged presence of SARS-CoV-2 RNA in faecal samples after the virus converting to negative in the respiratory system. Read More

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http://dx.doi.org/10.1177/1756284820934626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303511PMC

Disseminated Leishmaniasis Due to Using Immunosuppression Drugs: A Case Report.

Iran J Parasitol 2020 Apr-Jun;15(2):278-281

Pediatric's Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Visceral leishmaniasis is a common parasitic disease between humans and animals, transmitted by sandflies () in the Mediterranean countries, including Iran. The statistics have been reported less than real due to errors in the diagnosis and reporting of affected cases. In this report, we will present the symptoms and manifestations of this disease to reduce late detection and exacerbating factors. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311812PMC

Improved liver metastasis detection using Kupffer-phase imaging in contrast-enhanced harmonic EUS in patients with pancreatic cancer (with video).

Gastrointest Endosc 2020 Jun 24. Epub 2020 Jun 24.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.

Background And Aims: Kupffer-phase imaging visualized by Sonazoid distribution into normal liver tissues upon phagocytosis by Kupffer cells, potentially aids in improving liver metastasis detection compared with fundamental B-mode EUS (FB-EUS). However, the diagnostic performance of Kupffer-phase imaging in contrast-enhanced harmonic EUS (CH-EUS) remains unclear. Hence, this study aimed to evaluate the usefulness of CH-EUS-based Kupffer-phase imaging for diagnosing liver metastasis from pancreatic cancer. Read More

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http://dx.doi.org/10.1016/j.gie.2020.06.051DOI Listing

Nuclear ErbB2 expression in hepatocytes in liver disease.

Virchows Arch 2020 Jun 26. Epub 2020 Jun 26.

Institute of Pathology, Universitätsmedizin Greifswald, Friedrich-Loeffler-Straße 23e, 17475, Greifswald, Germany.

ErbB2 is a prominent representative of the epidermal growth factor receptors that mainly attract attention as oncogenic drivers and therapeutic targets in cancer. Besides transmembrane signaling, ErbB2 may also translocate into the nucleus and mediate distinct nuclear signaling effects including DNA repair and cell cycle arrest. Unexpectedly, we found nuclear ErbB2 expression in human hepatocytes in various liver diseases so we aimed to investigate the characteristics of liver disease leading to nuclear ErbB2 translocation. Read More

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http://dx.doi.org/10.1007/s00428-020-02871-zDOI Listing

Glycogen as an advantageous polymer carrier in cancer theranostics: Straightforward in vivo evidence.

Sci Rep 2020 Jun 26;10(1):10411. Epub 2020 Jun 26.

MR Unit, Department of Radiodiagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

As a natural polysaccharide polymer, glycogen possesses suitable properties for use as a nanoparticle carrier in cancer theranostics. Not only it is inherently biocompatible, it can also be easily chemically modified with various moieties. Synthetic glycogen conjugates can passively accumulate in tumours due to enhanced permeability of tumour vessels and limited lymphatic drainage (the EPR effect). Read More

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http://dx.doi.org/10.1038/s41598-020-67277-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320016PMC

Primary hepatic neuroendocrine carcinoma coexisting with distal cholangiocarcinoma: A case report and review of the literature.

Medicine (Baltimore) 2020 Jun;99(26):e20854

Department of Pathology, Third Central Hospital of Tianjin, Tianjin Third Central Hospital affiliated to Nankai University, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases.

Introduction: Although primary hepatic neuroendocrine carcinomas, whose prognostic mechanisms remain unclear, are rare, coexistence of neuroendocrine carcinomas and other tumors is rarer. In this report, we describe a unique case of coexistence between primary hepatic neuroendocrine carcinoma and a distal cholangiocarcinoma in the pancreas.

Patient Concerns: A 64-year-old woman with a history of diabetes, but none of hepatitis, was admitted to hospital because of intermittent epigastric distension and pain discomfort for more than 1 month aggravated 1 day. Read More

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http://dx.doi.org/10.1097/MD.0000000000020854DOI Listing

Genetic Differentiation of -Like Eggs in Northern Thailand Using Stool Specimens Under National Strategic Plan to Control Liver Fluke Infection and Cholangiocarcinoma.

Am J Trop Med Hyg 2020 Jun 22. Epub 2020 Jun 22.

Department of Parasitology, Phramongkutklao College of Medicine, Bangkok, Thailand.

Liver fluke infection caused by is recognized as a potential risk factor for cholangiocarcinoma (CCA). The National Strategic Plan to Control Liver Fluke Infection and Cholangiocarcinoma has implemented microscopic-based stool examination screening. However, eggs of and minute intestinal flukes (MIFs) are nearly morphologically similar and could result in inaccurate diagnosis. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0231DOI Listing

Post-transplant indolent T cell lymphoproliferative disorder in living donor liver transplantation: a case report.

Surg Case Rep 2020 Jun 26;6(1):147. Epub 2020 Jun 26.

Department of Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan.

Background: Post-transplant lymphoproliferative disorder (PTLD) of T cell type has been rarely reported. Accurate diagnosis of this life-threatening rare form of PTLD is important for the treatment strategy.

Case Presentation: A 7-year-old boy had severe diarrhea and weight loss progressively at 7 years post-living donor liver transplantation (LDLT) for biliary atresia. Read More

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http://dx.doi.org/10.1186/s40792-020-00904-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316934PMC

Two-dimensional ultrasound shear wave elastography for identifying and staging liver fibrosis in pediatric patients with known or suspected liver disease: a clinical effectiveness study.

Pediatr Radiol 2020 Jun 25. Epub 2020 Jun 25.

Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Background: Ultrasound shear wave elastography (SWE) measures liver stiffness noninvasively, but few studies have defined cutoff values for detecting liver fibrosis in pediatric patients using 2-D ultrasound SWE.

Objective: To evaluate the diagnostic performance of 2-D ultrasound SWE and define cutoff values for liver fibrosis in pediatric patients, using Canon (Toshiba) Aplio ultrasound systems.

Materials And Methods: This was an institutional review board-approved retrospective study of patients (≤18 years old) who had undergone both liver 2-D ultrasound SWE and percutaneous liver biopsy within 6 months. Read More

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http://dx.doi.org/10.1007/s00247-020-04720-2DOI Listing

Diagnostic challenges in non-cirrhotic portal hypertension - porto sinusoidal vascular disease.

World J Gastroenterol 2020 Jun;26(22):3000-3011

University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca 400000, Romania.

Non-cirrhotic portal hypertension consists of a group of diseases characterized by signs and complications of portal hypertension, which differ from cirrhosis through histological alterations, hemodynamic characterization and, clinical outcome. Because of the similarities in clinical presentation and imaging signs, frequently these patients, and particularly those with porto-sinusoidal vascular disease (PSVD), are misdiagnosed as having liver cirrhosis and thus raising difficulties in their diagnosis. The most challenging differentiation to be considered is between PSVD and cirrhosis and, although not pathognomonic, liver biopsy is still the standard of diagnosis. Read More

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http://dx.doi.org/10.3748/wjg.v26.i22.3000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304099PMC

Cholangitis lenta: an underdiagnosed lesion associated with severe cholestasis following liver transplantation.

Clin Transplant 2020 Jun 24:e14016. Epub 2020 Jun 24.

Department of General Surgery and Liver Transplantation, Hospices Civils de Lyon, Université Claude-Bernard Lyon 1, Croix-Rousse University Hospital, Lyon, France.

Background: Cholangitis lenta (CL) represents a specific histological lesion associated with severe cholestasis and related to sepsis. Despite being well-known by pathologists, CL has been poorly studied in liver transplantation (LT).

Methods: We performed a retrospective 12-year analysis of the incidence, risk factors and outcome of CL in LT recipients. Read More

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http://dx.doi.org/10.1111/ctr.14016DOI Listing

Liver biopsy for hepatoblastoma: a single institution's experience.

Pediatr Surg Int 2020 Aug 25;36(8):909-915. Epub 2020 Jun 25.

Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9 Jinsui Road, Tianhe District, Guangzhou, 510623, China.

Background/purpose: Hepatoblastoma diagnoses require liver biopsies. We aimed to investigate factors affecting the success of liver biopsy for hepatoblastoma diagnoses.

Methods: Data from patients with hepatoblastoma, including their demographic and clinical data, biopsy procedure information, pathologic diagnoses and subclassification, and surgical complications, were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s00383-020-04702-3DOI Listing

Primary anorectal malignant melanoma with laparoscopic abdominoperineal resection: a case study and review of the relevant literature.

Int Cancer Conf J 2020 Jul 17;9(3):116-122. Epub 2020 Apr 17.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

ARMM is a disease with a poor prognosis. ARMM is often diagnosed at an advanced stage, and the 5-year survival rate of ARMM is < 20%. Although the number of case reports on ARMM is gradually increasing, the optimal treatment strategy for ARMM remains controversial. Read More

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http://dx.doi.org/10.1007/s13691-020-00401-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297936PMC