81 results match your criteria Diagnostic Histopathology [Journal]


Study design.

Diagn Histopathol (Oxf) 2016 Jul;22(7):246-252

Programme Leader, MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK. Conflicts of interest: None.

A brief survey is provided of common designs for medical studies and important issues in their implementation. The designs discussed include those for laboratory studies, clinical trials, cohort studies, case-control and related studies, and diagnostic studies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17562317163006
Publisher Site
http://dx.doi.org/10.1016/j.mpdhp.2016.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983654PMC
July 2016
10 Reads

Unusual variants of mycosis fungoides.

Diagn Histopathol (Oxf) 2016 Apr 21;22(4):142-151. Epub 2016 May 21.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, USA.

Conventional presentations of mycosis fungoides may be diagnostically challenging, particularly in light of the controversial boundaries defining the disease. Variant presentations of this cutaneous T-cell lymphoma add a further layer of complexity, requiring a sophisticated and informed perspective when evaluating lymphoid infiltrates in the skin. Herein we discuss well-defined (WHO-EORTC) variants pagetoid reticulosis, granulomatous slack skin and folliculotropic mycosis fungoides as well as less well-defined morphologic/architectural variants, and divergent immunohistochemical presentations of this typically indolent T-cell lymphoproliferative disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17562317163001
Publisher Site
http://dx.doi.org/10.1016/j.mpdhp.2016.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720164PMC
April 2016
18 Reads

Use of human specimens in research: the evolving United States regulatory, policy, and scientific landscape.

Diagn Histopathol (Oxf) 2013 Sep;19(9):322-330

Division of Anatomic Pathology, Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA.

The use of human specimens in research has contributed to significant scientific and medical advancements. However, the development of sophisticated whole genome and informatics technologies and the increase in specimen and data sharing have raised new questions about the identifiability of specimens and the protection of participants in human specimen research. In the US, new regulations and policies are being considered to address these changes. Read More

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http://dx.doi.org/10.1016/j.mpdhp.2013.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954467PMC
September 2013
9 Reads

MOLECULAR MARKERS OF EARLY CERVICAL NEOPLASIA.

Diagn Histopathol (Oxf) 2010 Oct;16(10):445-454

Department of Pathology at the Federal University of Paraná, Curitiba, PR, Brazil. Conflicts of interest: Alvaro Pinto received test reagents from Becton, Dickinson and Company to perform comparisons of ProEx C and other biomarkers.

Pure morphological distinction of high-grade squamous intraepithelial lesions (HSILs) from their mimics can be challenging. Diagnosis can be difficult with nonconventional HSILs associated with a metaplastic phenotype, squamous intraepithelial lesions (SILs) that defy precise classification such as "eosinophilic dysplasias", and those that overlap with columnar neoplasms, including stratified variants of adenocarcinoma in situ ("SMILE"). Gene expression and protein profiling have identified biomarkers with the potential to decrease diagnostic variability and increase specificity of histological and cytological analysis. Read More

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http://dx.doi.org/10.1016/j.mpdhp.2010.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975942PMC
October 2010
6 Reads

Recent advances in the understanding of the pathogenesis of serous carcinoma: the concept of low- and high-grade disease and the role of the fallopian tube.

Diagn Histopathol (Oxf) 2008 Aug;14(8):352-365

Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

In the past 50 years, the concept of serous ovarian cancer has been progressively refined, with the distinction of the borderline serous tumour, identification of a smaller subset of well-differentiated serous malignancies and, recently, closer attention to the pathogenesis of high-grade serous malignancies. High-grade serous carcinoma, traditionally presumed to arise within Müllerian inclusion cysts of the ovarian surface, cortex and peritoneum, has recently been linked to the distal fallopian tube. This review addresses the disparate forms of serous neoplasia, which reflect both different genetic abnormalities and stages of differentiation of Müllerian epithelium. Read More

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http://dx.doi.org/10.1016/j.mpdhp.2008.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955447PMC
August 2008
12 Reads

Cystic lesions of the pancreas.

Diagn Histopathol (Oxf) 2008 Jun;14(6):260-265

Department of Pathology and Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.

In contrast to the relatively uniform pathology and the unyielding dismal outcome associated with infiltrating ductal adenocarcinoma of the pancreas, cystic lesions have a broad spectrum of gross and microscopic pathologies, and a range of clinical outcomes. The common cystic lesions of the pancreas are reviewed with emphasis on practical tips for distinguishing between the main entities. Read More

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http://dx.doi.org/10.1016/j.mpdhp.2008.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955458PMC
June 2008
6 Reads

The pathogenesis of prostate cancer: from molecular to metabolic alterations.

Diagn Histopathol (Oxf) 2008 May;14(5):195-201

Dana-Farber Cancer Institute, Massachusetts, USA.

Prostate cancer (PCa) is a heterogeneous disease with regard to molecular alterations and clinical course. The investigation of genetic alterations associated with PCa pathogenesis is highly challenging. Genome-wide analyses and epidemiological studies have identified only a handful of candidate genes possibly associated with hereditary or sporadic PCa. Read More

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http://dx.doi.org/10.1016/j.mpdhp.2008.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955448PMC
May 2008
10 Reads

The prevalence and prognostic significance of trophoblastic proteins in testicular teratoma.

Diagn Histopathol 1983 Jul-Dec;6(3-4):247-52

Testicular neoplasms incorporating trophoblastic tumour can contain HCG, SPI and PP5 and have a bad prognosis. These placental proteins also may be localized immunocytochemically in other germ cell tumours in isolated cells which morphologically resemble those in the syncytial layer of trophoblastic tumour, but the prognostic significance of these syncytial giant cells is not established. In sections from 89 malignant teratoma intermediate tumours of pathological stage P1 syncytial giant cells containing HCG were observed in 66 per cent, PP5 in 47 per cent and SPI in 46 per cent. Read More

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July 1984
5 Reads

A prognostic index based on the mean nuclear area of breast cancer cells and efferent vascular invasion in the axillary nodes.

Diagn Histopathol 1983 Jul-Dec;6(3-4):221-8

Statistical evaluation of the prognostic impact of different variants of the mean nuclear area (MNA) of tumour cells in breast carcinoma was used to find an optimal combination for use in conjunction with the absence/presence of tumour cells in the efferent vessels of the axillary nodes (EVI). This model gives an estimate of the relative prognostic impact of the different variables and their reliability. Combination of EVI with MNA of the primary tumour gave the optimal prediction of disease outcome; 81 per cent correct prediction before 60 months, falling to 73 per cent by 98 months after the operation. Read More

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July 1984
5 Reads

Xanthogranulomatous pyelonephritis: a pathological, clinical and aetiological analysis of 87 cases.

Diagn Histopathol 1983 Jul-Dec;6(3-4):203-19

Analysis of 87 cases of xanthogranulomatous pyelonephritis ( XPN ) from 1958 to 1983 (14 males, 73 females, ages 13-85) revealed an incidence of 1.4 cases/100 000 population per annum which is apparently increasing. Clinical, radiological and pathological investigations demonstrated universal urinary obstruction (77. Read More

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July 1984
6 Reads

Concretions in renal basement membranes.

Diagn Histopathol 1983 Jul-Dec;6(3-4):195-202

A study of 196 renal biopsies was carried out by electron microscopy. In 78 cases concretions were detected, which x-ray microanalysis (EDAX) proved to be calcium phosphate deposits. Concretions always occurred in damaged basement membranes, especially in the basement membranes of Bowman's capsules and of proximal convoluted tubules. Read More

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July 1984
7 Reads

The so-called intravascular bronchioloalveolar tumour of lung (low grade sclerosing angiosarcoma): presentation with extrapulmonary deposits.

Diagn Histopathol 1983 Jul-Dec;6(3-4):229-37

Two further cases of the so-called intravascular bronchioloalveolar tumour of lung are reported. Electron microscopic demonstration of Weibel-Palade bodies and immunocytochemical demonstration of factor VIII in the cytoplasm of the tumour cells indicate the vascular nature of these lesions. One patient presented with an enlarged liver and the tumour was found to be involving the liver and parietal pleura as well as the lung. Read More

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July 1984
4 Reads

Serotonin and its possible role in the painful non-inflamed appendix.

Authors:
A P Dhillon J Rode

Diagn Histopathol 1983 Jul-Dec;6(3-4):239-46

After immunohistochemical staining appendices without active inflammation but producing symptoms of appendicitis (N = 24) were compared with a control group of appendices removed incidental to another procedure (N = 26). Staining for neurone specific enolase (NSE) showed more instances of nerve 'hyperplasia' in the control group than in the appendices generating pain refuting the concept of neuroappendicopathy based on quantitative nerve changes. Serotonin staining identified subepithelial neuroendocrine cells (SNC) in 85 per cent of the specimens. Read More

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July 1984
5 Reads

Significance and function of multinucleate giant cells in de Quervain's thyroiditis.

Authors:
H Cain B Kraus

Diagn Histopathol 1983 Jul-Dec;6(3-4):181-93

Thyroid gland resections from 12 patients suffering from de Quervain's thyroiditis were investigated by light-, electron- and immunofluorescence-microscopy as well as enzymehistochemically . Several granulomas were serially sectioned. The giant cells of de Quervain's thyroiditis arise from the fusion of mononuclear precursors. Read More

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July 1984
5 Reads

Lectin binding to normal and malignant breast tissue.

Diagn Histopathol 1983 Jul-Dec;6(3-4):171-80

The major carbohydrate groups expressed by normal breast epithelium and primary breast cancers were identified by lectins, using an immunoperoxidase method on paraffin sections. All the lectins (pokeweed, lotus, wheatgerm, peanut, helix, bandeiraea 1, soybean and concanavalin A) bound to breast cancer cells with a variable cytoplasmic, luminal surface or intercellular pattern. Not all cancer cells bound lectins, suggesting sub-populations within individual tumours. Read More

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July 1984
5 Reads

Lung tumours: a personal review.

Authors:
R H Steele

Diagn Histopathol 1983 Jul-Dec;6(3-4):119-69

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July 1984
5 Reads

The pathology of non-Rhesus hydrops.

Diagn Histopathol 1983 Apr-Jun;6(2):89-111

The pathological findings in 50 cases of non-Rhesus hydrops are presented. In 19, pregnancy terminated before the twenty-eighth week of gestation; there were five chromosomally abnormal fetuses and a further six with structural abnormality in this group. Three of 31 infants from the more mature group survived, 16 were stillborn and 12 died in the neonatal period. Read More

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March 1984
7 Reads

Pulmonary capillary haemangiomatosis.

Diagn Histopathol 1983 Apr-Jun;6(2):77-84

A Cypriot male of 22 years died after suffering recurrent daily haemoptyses of varying severity and slowly increasing effort intolerance for a period of four and a half years. Examination of a lung biopsy specimen revealed dilated vascular channels suggestive of a congenital anomaly of the pulmonary vasculature. Histological examination of the lung following necropsy revealed the diagnosis of pulmonary capillary haemangiomatosis. Read More

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March 1984
4 Reads

The secretory immunoglobulin system in urothelial neoplasia.

Diagn Histopathol 1983 Apr-Jun;6(2):85-8

The role of the secretory immunoglobulin system in urinary tract neoplasia has been investigated by staining formalin-fixed, paraffin-wax embedded sections of normal and abnormal urinary tract epithelium for secretory component (SC), IgA and J (joining) chain. Normal mucosa contains IgA with J chain and SC as a thin superficial layer on surface umbrella cells and in small amounts in the cytoplasm of intermediate cells. Inflamed mucosa is infiltrated by many IgA and J chain positive plasma cells in the lamina propria and there is IgA, SC and J chain in the cytoplasm of the second layer of the epithelium as much as in surface umbrella cells. Read More

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March 1984
9 Reads

Tenosynovial fibroma.

Diagn Histopathol 1983 Apr-Jun;6(2):69-76

Tenosynovial fibroma or angiofibroma of tendon sheath is a distinctive clinicopathological entity occurring mainly in young and middle-aged men and affecting dominantly the distal extremities. Fingers, hands and wrists are the site of 80 per cent of cases. Palmar aspects of hands and plantar aspects of foot are preferentially involved. Read More

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March 1984
7 Reads

The fine structure of the human breast and its benign disorders.

Diagn Histopathol 1983 Apr-Jun;6(2):51-67

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March 1984
5 Reads

Immunohistochemical studies of S100 protein and other neural characteristics expressed by granular cell tumour.

Authors:
A P Dhillon J Rode

Diagn Histopathol 1983 Jan-Mar;6(1):23-8

Eight cases of granular cell tumour (GCT), five Schwannomas and two neurofibromas were examined immunohistochemically for the presence of S100 protein, neurofilament protein (NP), epidermal growth factor (EGF) and glial fibrillary acidic protein (GFAP). The solochrome cyanin stain for myelin was also applied. All cases of GCT showed staining for S100 protein. Read More

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September 1983
5 Reads

Primary adenoid cystic carcinoma of the oesophagus.

Diagn Histopathol 1983 Jan-Mar;6(1):39-46

The light and electron microscopic appearances of a primary adenoid cystic carcinoma of the oesophagus are described in a 70 year old male patient. A large tumour in the lower third of the oesophagus was resected. The tumour exhibited a polypoid appearance and was histologically identical to the previously described adenoid cystic carcinoma of the oesophagus. Read More

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September 1983
5 Reads

Hepatitis induced by drugs used as alcohol aversion therapy.

Diagn Histopathol 1983 Jan-Mar;6(1):29-37

We report here on the hepatic lesions produced in 17 alcoholic patients who had received Cyanamide or Disulfiram as aversion therapy. The characteristic lesion consists of cytoplasmic inclusions, similar to Lafora bodies. They are found predominantly in periportal hepatocytes, including those lining the cholangioles. Read More

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September 1983
5 Reads

Oestrogen receptors in human breast cancer: review of histopathological correlations and critique of histochemical methods.

Authors:
J C Underwood

Diagn Histopathol 1983 Jan-Mar;6(1):1-22

Correlations between the oestrogen receptor (ER) content and histology of human breast cancer are reviewed. Although conventional receptor assays of tissue homogenates may give misleading results because of tumour heterogeneity, certain trends are apparent: lobular carcinomas are rather more commonly ER positive than are ductal carcinomas; cellularity, differentiation, elastosis, and paucity of stromal lymphocytes are positively correlated with ER content in ductal carcinomas. Attempts to detect and localize steroid hormone binding sites in breast cancer cells or sections by histochemical or immunohistochemical methods do not satisfy the criteria for demonstrating classical high affinity cytosolic receptors. Read More

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September 1983
5 Reads

Efferent vascular invasion and the mean nuclear area of axillary nodal tumour cells in breast cancer.

Diagn Histopathol 1982 Oct-Dec;5(4):297-300

The presence of tumour cells of high mean nuclear area (MNA) in axillary nodal metastases from breast carcinoma is shown to be related to the finding of tumour cells in the efferent nodal vessels. In cases without efferent vascular invasion (EVI) the MNA was on average lower. EVI positivity combined with a high MNA is associated with a poor prognosis. Read More

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June 1983
5 Reads

Squamous cell papilloma of the esophagus: a tumour probably caused by human papilloma virus (HPV).

Diagn Histopathol 1982 Oct-Dec;5(4):291-6

The third well-documented case of an oesophageal squamous cell papilloma in the literature is studied by light microscopy and using an indirect immunoperoxidase-PAP technique. Human papilloma virus (HPV) antigens were found within the nuclei of the superficial dyskeratotic cells and of koilocytes, both of which are characteristic cells found in HPV lesions elsewhere in the body. The findings are discussed in the light of current concepts of HPV lesions in general. Read More

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June 1983
5 Reads

Demonstration of fibronectin in soft tissue tumours using the immunoperoxidase technique.

Authors:
C E Du Boulay

Diagn Histopathol 1982 Oct-Dec;5(4):283-9

A variety of reactive, benign and malignant soft tissue lesions have been stained for fibronectin using the immunoperoxidase technique. Two patterns of mesenchymal staining have emerged. The first has a diffuse stromal collagen and basement membrane distribution within normal and neoplastic mesenchyme and the second a more specific intracytoplasmic granular staining pattern. Read More

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June 1983
5 Reads

Diagnosis and classification of primary glomerulonephritis: a review.

Authors:
A G MacIver

Diagn Histopathol 1982 Oct-Dec;5(4):231-81

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June 1983
5 Reads

Squamous cell carcinoma of bronchus: polypoid granules and mitochondrial densities found by electron microscopy.

Authors:
B E Heard A Dewar

Diagn Histopathol 1982 Jul-Sep;5(3):189-95

In the course of studying a series of human bronchial and lung carcinomas by electron microscopy, we have come across a squamous cell (epidermoid) carcinoma containing two different kinds of small bodies that have not been described previously. One of them took the form of small round dense granules projecting from the surface of keratinizing tumour cells, which we have termed 'polypoid granules'. The other consisted of small oval dark densities associated with the outer membranes of the mitochondria of non-keratinizing tumour cells, which we have termed 'mitochondrial densities'. Read More

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January 1983
6 Reads

The measurement of mucosal non-myelinated nerve fibre area and endocrine cell area in coeliac disease using morphometric analysis.

Authors:
J G Jones M E Elmes

Diagn Histopathol 1982 Jul-Sep;5(3):183-8

A preliminary morphometric analysis of non-myelinated nerve fibres and endocrine cells in the mucosa of normal and coeliac jejunal biopsies has been performed at the ultrastructural level. Biopsies from 5 children with histologically normal mucosa and 5 children with coeliac disease have been analysed. The percentage of endocrine cells per unit of crypt epithelial area, the percentage nerve area per unit area of lamina propria and the lamina propria area per unit length of mucosa in the crypt base region has been measured in ultrathin sections. Read More

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January 1983
5 Reads

Pilar tumour: a distinctive type of trichilemmoma.

Diagn Histopathol 1982 Jul-Sep;5(3):157-67

A series of pilar tumours is presented. Although they are predominantly tumours of the elderly female, they occur also in men and in middle age. Some 90 per cent occur on the scalp or nape of neck; about 10 per cent affect other areas. Read More

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January 1983
6 Reads

2-hydroxystilbamidine isethionate: a new fluorochrome for use in general pathology. II. The selective demonstration of fungi.

Authors:
L B Murgatroyd

Diagn Histopathol 1982 Jul-Sep;5(3):219-22

Paraffin sections of kidney, lung and oesophagus containing Aspergillus sp., Cryptococcus neoformans and Candida sp. were taken from human post mortem material and from the marmoset Callithrix jacchus. Read More

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January 1983
5 Reads

The prune belly syndrome--a possible pathogenesis.

Diagn Histopathol 1982 Jul-Sep;5(3):197-203

Several pathogenetic mechanisms have been suggested to explain the syndrome of deficiency of anterior abdominal muscles and genitourinary abnormalities which is usually seen in males. We have recently seen four such cases, two males and two females, all of which showed obstruction of the lower urinary tract, with dilatation proximally. We wish to suggest that the atrophy of abdominal muscles occurs following venous infarction, due to gross over-distension of the abdomen. Read More

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January 1983
5 Reads

Immunohistochemical staining of granular cell tumour for neurone specific enolase: evidence in support of a neural origin.

Diagn Histopathol 1982 Jul-Sep;5(3):205-11

Eight cases of benign granular cell tumour of tongue and skin all showed immunohistochemical staining for neurone specific enolase (NSE). Four Schwannomas, two neurofibromas and Schwann cells of nerves related to these tumours and the granular cell tumours showed no staining for NSE. NSE is a marker for neuronal type cells of the nervous system and cells of the neuroendocrine system. Read More

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January 1983
4 Reads

Enolase isoenzymes in benign and malignant melanocytic lesions.

Diagn Histopathol 1982 Jul-Sep;5(3):175-81

The distributions of the alpha, beta and gamma subunits of enolase were studied in 34 melanocytic lesions using the peroxidase-antiperoxidase (PAP) technique. Melanocytes in benign neoplasms stained moderately strongly for both alpha enolase and gamma enolase but staining for beta enolase was consistently negative. Staining for alpha enolase was always stronger than that for gamma enolase. Read More

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January 1983
5 Reads

Patterns of staining for neurone specific enolase in benign and malignant melanocytic lesions of the skin.

Authors:
A P Dhillon J Rode

Diagn Histopathol 1982 Jul-Sep;5(3):169-74

Neurone specific enolase (NSE) is a useful marker for melanoma independent of the criterion of melanogenesis. A range of benign and malignant melanocytic skin lesions has been studied to assess the diagnostic potential of staining for NSE. The detailed features of the presence and distribution of NSE in 47 skin lesions are presented. Read More

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January 1983
6 Reads

Follicular carcinoma of the human thyroid gland: an ultrastructural study with emphasis on scanning electron microscopy.

Diagn Histopathol 1982 Apr-Jun;5(2):113-27

Previous ultrastructural studies on follicular thyroid carcinomas present conflicting results, in particular with regard to the surface features of the neoplastic cells. The present study of 9 cases with varying degrees of differentiation is the first comprehensive investigation by concurrent transmission and scanning electron microscopy. In the well-differentiated tumours we found a slightly increased number of microvilli and a decreased number of cilia per cell as compared to the normal thyroid follicles, while moderately differentiated tumours had a smaller number of microvilli and no cilia. Read More

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September 1982
6 Reads

The identification and classification of non-hodgkin's lymphoma: A review.

Authors:
D H Wright

Diagn Histopathol 1982 Apr-Jun;5(2):73-111

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September 1982
6 Reads

Silicone lymphadenopathy: a report of two cases, one with concomitant malignant lymphoma.

Diagn Histopathol 1982 Apr-Jun;5(2):133-41

Two cases of axillary lymphadenopathy induced by foreign body reaction to silicone particles are presented. Both were patients with longstanding arthritis who had silastic metacarpophalangeal joint implants; one patient also had concomitant lymphoma. The material was conclusively identified as silicone by electron microprobe analysis. Read More

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September 1982
5 Reads

Mast cells in the axillary nodes of breast cancer patients.

Diagn Histopathol 1982 Jan-Mar;5(1):65-7

Mast cell counts on lymph nodes from 64 patients with infiltrating breast carcinoma showed that in the absence of metastases to any of the axillary nodes few mast cells were present. If metastases were present in any of these nodes, both those with and those without tumour showed higher mast cell counts. Thus it seems that it is the presence or absence of tumour in the axilla as a whole, rather than within the individual node, that is associated with the change in mast cell count. Read More

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June 1982
5 Reads

Image analysis of neuroblastomas-discrimination of prognostic patterns.

Authors:
A Moragas N Toran

Diagn Histopathol 1982 Jan-Mar;5(1):53-7

In a series of 52 neuroblastomas with a three-year follow-up textural analysis by means of sequential transformation of the image enabled us to establish a prognostic stratification of the cases taking the value of the specific area at the tenth closure as a discriminant of the grade of differentiation. The curves obtained plotting the closing function mainly yield information on the size distribution and characteristics of the intercellular stroma, which largely corresponds to the neurofibrillar set. The correlation between the specific area at the tenth closure and the age of the children prompt us to consider two different trends in neuroblastomas, those which invariably lead to death and whose grade of differentiation bears no correlation with the outcome, and those which undergo spontaneous or treatment-induced regression, and whose maturity has a linear relationship with the age of the child at diagnosis. Read More

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June 1982
5 Reads

Effects of small latex particle uptake on the surface connected canalicular system of blood platelets: a freeze-fracture and cytochemical study.

Diagn Histopathol 1982 Jan-Mar;5(1):3-10

Recent investigations have suggested that channels of the surface connected open canalicular system are the major source of membrane contributing to increased surface area of platelets following activation or uptake of particulates. However, study of large latex particle phagocytosis suggested that channels filled with spherules become dilated and lose connections with the outer surface, but do not become extruded onto the platelet membrane. The present study has employed electron dense tracers, freeze-fracture and transmission electron microscopy to follow the uptake of small latex spherules by blood platelets. Read More

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June 1982
6 Reads

The mononuclear phagocyte system of the mouse as demonstrated by the immunoperoxidase technique using anti-mouse macrophage antiserum.

Diagn Histopathol 1982 Jan-Mar;5(1):19-32

With an antibody raised to mouse peritoneal macrophages, it is possible to demonstrate macrophages in various murine tissues using an immunoperoxidase technique. The distribution of these cells is described and illustrated. The antigenic determinant(s) appears to reside on the macrophage surface and this has been confirmed by appropriate electron microscopic studies of stained Kupffer cells. Read More

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June 1982
4 Reads

An immunocytochemical study of the distribution of epithelial membrane antigen in normal and disordered squamous epithelium.

Diagn Histopathol 1982 Jan-Mar;5(1):11-7

Using immunocytochemical techniques, we have investigated the distribution of epithelial membrane antigen (EMA) in human squamous epithelium. The antigen is not demonstrable in normal adult tissues although it is present on the surface membrane of normal foetal epidermis before keratinization takes place. It may be expressed strongly in the adult, however, in in situ and infiltrative squamous carcinomas as well as in a variety of non-neoplastic states. Read More

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June 1982
7 Reads

Ultrastructural diagnosis of large cell 'undifferentiated' neoplasia.

Authors:
J J Gillespie

Diagn Histopathol 1982 Jan-Mar;5(1):33-51

Large cell undifferentiated neoplasia' provides a generic designation for a heterogeneous group of neoplasms which by histological study, are devoid of discriminate architecture and appear under the light microscope as patternless sheets of large cytoplasmic cells. The interpretation of such a tumour will routinely present significant problems in differential diagnosis. By conventional light microscopy the neoplasm may subjectively be judged to represent a certain form of carcinoma or large cell lymphoma, but often identification is relegated to a label of "consistent with', or "undifferentiated malignant neoplasm'. Read More

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June 1982
5 Reads

Alveolar trapping in pulmonary carcinomas.

Diagn Histopathol 1982 Jan-Mar;5(1):59-64

Sixty surgically resected pulmonary carcinomas have been studied by light and electron microscopy for engulfed alveolar cavities within the tumour mass. Alveoli had been incorporated in twelve cases, ten epidermoid (squamous) carcinomas and two adenocarcinomas. They were lined by granular pneumocytes and cells transitional between granular and membranous pneumocytes. Read More

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June 1982
5 Reads