6,992 results match your criteria Diabetology & Metabolic Syndrome [Journal]


Biallelic loss of function variants in PPP1R21 cause a neurodevelopmental syndrome with impaired endocytic function.

Hum Mutat 2018 Dec 6. Epub 2018 Dec 6.

Genome Research Division, Human Genetics department, Radboud University Medical Center Nijmegen and Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.

Next-generation sequencing has been instrumental in solving the genetic basis of rare inherited diseases, especially neurodevelopmental syndromes. However, functional workup is essential for precise phenotype definition and to understand the underlying disease mechanisms. Using whole exome and whole genome sequencing in 4 independent families with hypotonia, neurodevelopmental delay, facial dysmorphism, loss of white matter and thinning of the corpus callosum, we identified 4 previously unreported homozygous truncating PPP1R21 alleles: c. Read More

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December 2018

Response to "Preserved" glucagon secretion in fulminant type 1 diabetes.

J Diabetes Investig 2018 Dec 6. Epub 2018 Dec 6.

Department of Diabetes, Endocrinology and Metabolism, Center Hospital, National Center for Global Health and Medicine.

We compared the glucagon responses to arginine stimulation in five patients with fulminant type 1 diabetes and five age- and diabetes duration-matched acute-onset type 1 diabetes, and the curves of the glucagon responses were similar. In our study, we measured the glucagon levels by not only radioimmunoassay, but also novel enzyme-linked immunosorbent assay. Read More

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December 2018

Predictive factors associated with 3 years of response to HbA1c goal with exenatide QW or insulin glargine: Post hoc analysis of DURATION-3.

Diabetes Obes Metab 2018 Dec 5. Epub 2018 Dec 5.

VA San Diego Healthcare System and Department of Medicine, University of California San Diego School of Medicine, California.

This DURATION-3 study post hoc analysis aimed to identify factors associated with sustained glycaemic response with exenatide once weekly (QW) or insulin glargine (IG) among patients with type 2 diabetes. Response was defined as achieving treatment target of HbA1c <7.0% (<53 mmol/mol) at week 26; sustained responders maintained treatment target for ≥80% of remaining visits, including 1 during the final 6 months. Read More

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December 2018

Impact of Baseline BMI on Glycemic Control and Weight Change with Exenatide Monotherapy in Chinese Drug-naïve Type 2 Diabetic Patients.

J Diabetes 2018 Dec 5. Epub 2018 Dec 5.

Key Lab of Diabetology of Guangdong Province, Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Background: The weight reduction effect of exenatide has been well proved, which may concern physicians about too much weight loss in patients with normal weight. This study evaluated the effects of exenatide monotherapy on glycemic control and weight change among normal-weight, overweight, and obese patients with newly diagnosed type 2 diabetes (T2D).

Methods: In this multicenter, prospective study, 29 normal-weight, 54 overweight, and 27 obese newly diagnosed and drug-naive patients with T2D were treated with exenatide for 48 weeks. Read More

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December 2018

Assessing the effects of long-term osteoporosis treatment by using conventional spine radiographs: results from a pilot study in a sub-cohort of a large randomized controlled trial.

Skeletal Radiol 2018 Dec 1. Epub 2018 Dec 1.

Department of Internal Medicine, Division of Endocrinology & Diabetology, Medical University of Graz, Auenbruggerpl. 15, 8036, Graz, Austria.

Objective: To evaluate the clinical applicability of a software tool developed to extract bone textural information from conventional lumbar spine radiographs, and to test it in a subset of postmenopausal women treated for osteoporosis with the fully human monoclonal antibody denosumab.

Methods: The software was developed based on the principles of a fractal model using pixel grey-level variations together with a specific machine-learning algorithm. The obtained dimensionless parameter, termed bone structure value (BSV), was then tested and compared to bone mineral density (BMD) in a sub-cohort of postmenopausal women with osteoporosis who were treated with the monoclonal antibody denosumab, within the framework of a large randomized controlled trial and its open-label extension phase. Read More

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December 2018

Early screening for gestational diabetes mellitus is not associated with improved pregnancy outcomes: an observational study including 9795 women.

Diabetes Metab 2018 Nov 28. Epub 2018 Nov 28.

Paris 13 university, Sorbonne Paris Cité, AP-HP, Jean-Verdier hospital, department of obstetrics and gynecology, Bondy, France.

Aims: In addition to screening for hyperglycaemia during pregnancy after 24 weeks of gestation (WG), the current guidelines also suggest screening in early pregnancy and referring women with early gestational diabetes mellitus (eGDM) or overt diabetes (OD) for immediate care. Our aim was to evaluate this strategy.

Methods: This study evaluated, at our hospital (2012-2016), whether the incidence of a predefined composite outcome (preeclampsia, large-for-gestational-age infant, shoulder dystocia) and secondary outcomes was different when women were screened only after 22WG ('late screening only') or before 22WG and treated for eGDM or OD if present, with repeat screening after 22WG if absent ('early ± late screening'). Read More

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November 2018

Hypotonia and delayed motor development as an early presentation of Lowe syndrome: case report and literature review.

Acta Clin Belg 2018 Dec 3:1-5. Epub 2018 Dec 3.

a Department of Pediatrics, Division of Pediatric Nephrology and Rheumatology , Ghent University Hospital , Ghent , Belgium.

We describe a boy who presented with neonatal hypotonia, followed by delayed motor development and growth impairment. Further evaluation revealed rickets caused by proximal renal tubular dysfunction. At age 3, the boy exhibited dysmorphic features and bilateral cataract. Read More

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December 2018

68Ga-DOTA-TOC PET/CT of von Hippel-Lindau Disease.

Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.

From the Divisions of Nuclear Medicine, and.

We present a rare case of a 42-year-old man with a long history of von Hippel-Lindau disease that was scanned with Ga-DOTA-TOC PET/CT for suspicion of disease relapse. Ga-DOTA-TOC imaging demonstrated increased DOTA-TOC uptake in pancreas tail and intramedullary and extramedullary spinal hemangioblastomas, only some of which have already been highlighted at MRI examination. This case illustrates the significant role the Ga-labeled somatostatin receptor analogs PET/CT in the management of the von Hippel-Lindau disease. Read More

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December 2018

Nonadherence in patients with hypertensive emergency or hypertensive urgency.

J Clin Hypertens (Greenwich) 2018 Dec 5. Epub 2018 Dec 5.

Vth. Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany.

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December 2018

Identifying diabetes cases in health administrative databases: a validation study based on a large French cohort.

Int J Public Health 2018 Dec 4. Epub 2018 Dec 4.

Santé publique France (SpF), F-94415, Saint-Maurice, France.

Objectives: In the French national health insurance information system (SNDS) three diabetes case definition algorithms are applied to identify diabetic patients. The objective of this study was to validate those using data from a large cohort.

Methods: The CONSTANCES cohort (Cohorte des consultants des Centres d'examens de santé) comprises a randomly selected sample of adults living in France. Read More

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December 2018

Factor-XIII activity in patients with mild to moderate ulcerative colitis and active bleeding: a prospective observational study.

BMC Res Notes 2018 Dec 4;11(1):853. Epub 2018 Dec 4.

Practice for Digestive and Metabolic Diseases, Nordstr. 21, 04105, Leipzig, Germany.

Objective: Coagulation factor XIII plays a key role in fibrin clot stabilization and epithelial healing. Under chronic inflammatory conditions involving bleeding and an activation of the coagulation cascade, the FXIIIa inversely correlate with disease activity. We assumed that FXIIIa could be a predictor of severity in patients with ulcerative colitis (UC). Read More

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December 2018

Lipidomic Response to Coffee Consumption.

Nutrients 2018 Dec 1;10(12). Epub 2018 Dec 1.

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 North Lake Shore Drive, Suite 1400, Chicago, IL 60611, USA.

Coffee is widely consumed and contains many bioactive compounds, any of which may impact pathways related to disease development. Our objective was to identify individual lipid changes in response to coffee drinking. We profiled the lipidome of fasting serum samples collected from a previously reported single blinded, three-stage clinical trial. Read More

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December 2018
1 Read

Expression Profile of Diabetes-Related Genes Associated with Leukocyte Sirtuin 1 Overexpression in Gestational Diabetes.

Int J Mol Sci 2018 Nov 30;19(12). Epub 2018 Nov 30.

Department of Structural Biology, Faculty of Biomedical Sciences and Postgraduate Education, Medical University of Lodz, 90-752 Lodz, Poland.

Although compelling evidence indicates that Sirtuin 1 (SIRT1) plays a prominent role in type 2 diabetes, its relationship with gestational diabetes (GDM) remains elusive. This study was aimed at identifying diabetes-related genes and cellular pathways linked to changes of leukocyte expression at the time of GDM diagnosis. For this purpose, 122 GDM patients were screened for leukocyte expression, and two subgroups were distinguished, namely GDM/(↑) ( = 30, < 0. Read More

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November 2018

Exosomal proteins constitute an essential part of the human adipose tissue secretome.

Biochim Biophys Acta Proteins Proteom 2018 Nov 28. Epub 2018 Nov 28.

German Center for Diabetes Research (DZD e.V.), München, Germany; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Duesseldorf, Germany.

Adipose tissue is an endocrine organ, secreting various adipokines, either directly or via extracellular vesicles, including exosomes. Exosomes are vesicles of 40-150 nm size that represent a novel concept of biomolecule release. We purified exosomes from isolated primary human preadipocytes differentiated to mature adipocytes. Read More

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November 2018
2 Reads

Extensive cellular heterogeneity of X inactivation revealed by single-cell allele-specific expression in human fibroblasts.

Proc Natl Acad Sci U S A 2018 Dec 3. Epub 2018 Dec 3.

Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva, CH, Switzerland;

X-chromosome inactivation (XCI) provides a dosage compensation mechanism where, in each female cell, one of the two X chromosomes is randomly silenced. However, some genes on the inactive X chromosome and outside the pseudoautosomal regions escape from XCI and are expressed from both alleles (escapees). We investigated XCI at single-cell resolution combining deep single-cell RNA sequencing with whole-genome sequencing to examine allelic-specific expression in 935 primary fibroblast and 48 lymphoblastoid single cells from five female individuals. Read More

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December 2018

Regional differences of macrovascular disease in Northeast and South Germany: the population-based SHIP-TREND and KORA-F4 studies.

BMC Public Health 2018 Dec 3;18(1):1331. Epub 2018 Dec 3.

Institute for Biometrics and Epidemiology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany.

Background: Previous studies found regional differences in the prevalence and incidence of type 2 diabetes between Northeast and South of Germany. The aim of this study was to investigate if regional variations are also present for macrovascular disease in people with type 2 diabetes and in the general population. A further aim was to investigate if traditional risk factors of macrovascular complications can explain these regional variations. Read More

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December 2018
1 Read

Therapeutic options to reduce advanced glycation end products in patients with diabetes mellitus: A review.

Diabetes Res Clin Pract 2018 Nov 27. Epub 2018 Nov 27.

Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Diabetes mellitus (DM) defines metabolic disorders, characterised by elevated levels of blood glucose. Chronic hyperglycaemic state promotes consequently the formation of advanced glycation end products (AGEs) and the expression of their receptor (RAGE) which aggravate many diabetic complications. Due to the relevant role of AGEs and RAGE, several therapeutic approaches with an anti-AGE or RAGE-antagonizing effect are investigated. Read More

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November 2018

Feasibility of diffusion-weighted imaging with DWIBS in staging Hodgkin lymphoma in pediatric patients: comparison with PET/CT.

MAGMA 2018 Nov 29. Epub 2018 Nov 29.

Department of Diagnostic Imaging, Polish Mother's Memorial Hospital-Research Institute in Lodz, Rzgowska 281/289, 93-338, Lodz, Poland.

Objective: The aim of the study was to evaluate feasibility of diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) method in diagnosing Hodgkin lymphoma in pediatric patients and to compare it with 18F-FDG PET/CT as a gold standard.

Materials And Methods: Eleven patients (median age 14) with newly diagnosed Hodgkin lymphoma were examined with 18F-FDG PET/CT and MRI including whole-body DWIBS sequence (b = 0, 800 s/mm), before the oncologic treatment. About 26 locations of lymphatic tissues were evaluated visually and quantitatively using ADC (DWIBS) and SUV (18F-FDG PET/CT), respectively. Read More

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November 2018
4 Reads

Use of Metformin and Platelet Reactivity in Diabetic Patients Treated with Dual Antiplatelet Therapy.

Exp Clin Endocrinol Diabetes 2018 Nov 29. Epub 2018 Nov 29.

Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità", Eastern Piedmont University, Novara, Italy.

Background: Enhanced platelet reactivity represents one of the major determinants of cardiovascular risk among diabetic patients. The aim of the present study was to evaluate the impact of metformin use on platelet reactivity in diabetic patients receiving dual antiplatelet therapy (DAPT).

Methods: We included diabetic patients treated with DAPT after an acute coronary syndrome or percutaneous coronary intervention. Read More

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November 2018
1 Read

Dietary exposure to brominated flame retardants and risk of type 2 diabetes in the French E3N cohort.

Environ Int 2018 Nov 26;123:54-60. Epub 2018 Nov 26.

CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, 94805, Villejuif, France; Gustave Roussy, F-94805, Villejuif, France. Electronic address:

Introduction: The prevalence of type 2 diabetes (T2D) is increasing worldwide. Recent studies have suggested that environmental factors, such as exposure to brominated flame retardants (BFRs), could play a role in the epidemic of T2D. The aim of this study was to analyze the association between the dietary exposure to BFRs (Hexabromocyclododecane (HBCD) and Polybromodiphenylether (PBDE)) and T2D risk in the E3N prospective cohort of French women. Read More

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November 2018

Integrating clinical and genetic approaches in the diagnosis of 46,XY disorder of sex development.

Endocr Connect 2018 Nov 1. Epub 2018 Nov 1.

M Niedziela, Department of Pediatric Endocrinology and Rheumatology, Poznan University of Medical Sciences, Poznan, Poland.

Objective: 46,XY differences and/or disorders of sex development (DSD) are clinically and genetically heterogeneous conditions. Although complete androgen insensitivity syndrome has a strong genotype-phenotype correlation, the other types of 46,XY DSD are less well-defined and thus the precise diagnosis is challenging. This study focused on comparing the relationship between clinical assessment and genetic findings in a cohort of well-phenotyped patients with 46,XY DSD. Read More

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November 2018
2 Reads

Performance of the automated multiplex PCR Unyvero implant and tissue infections system in the management of diabetic foot osteomyelitis.

Future Microbiol 2018 Nov 29. Epub 2018 Nov 29.

U1047, INSERM, University Montpellier, Department of Microbiology, University Hospital Nimes, Nîmes, France.

Aim: We evaluated the performance of Unyvero implant and tissue infections system (ITI) application (Curetis) to diagnose Diabetic Foot Osteomyelitis (DFOM).

Patients & Methods: The study was conducted in the Diabetic Foot reference center of Nîmes University Hospital (France) from 1 December 2016 to 31 May 2017. We compared the Unyvero ITI PCR to conventional culture and alternative molecular approaches. Read More

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November 2018

Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes.

Front Physiol 2018 14;9:1622. Epub 2018 Nov 14.

Division of Cardiology, Medical University of Graz, Graz, Austria.

Some oral anti-hyperglycemic drugs, including gliptins that inhibit dipeptidyl peptidase 4 (DPP4), have been linked to the increased risk of heart failure (HF) in type-2 diabetic patients. While the cardiovascular safety trial, TECOS, revealed no link between sitagliptin and the risk of HF, a substantial 27% increase in the hospitalization for HF was observed in type-2 diabetic patients treated with saxagliptin within the SAVOR-TIMI 53 trial. A previous study revealed that saxagliptin impairs the Ca/calmodulin-dependent protein kinase II (CaMKII)-phospholamban (PLB)-sarcoplasmic reticulum Ca-ATPase 2a axis and protein kinase C (PKC) activity in cardiomyocytes leading to impaired cardiac contractility and electrophysiological function. Read More

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November 2018
2 Reads

Multiethnic Genome-wide Association Study of Diabetic Retinopathy using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control.

Diabetes 2018 Nov 28. Epub 2018 Nov 28.

Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA

To identify genetic variants associated with diabetic retinopathy (DR), we performed a large, multiethnic genome-wide association study (GWAS). Discovery included eight European cohorts (n = 3,246) and seven African American cohorts (n = 2,611). We meta-analyzed across cohorts using inverse-variance weighting, with and without liability threshold modeling of glycemic control and duration of diabetes. Read More

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November 2018
1 Read
8.095 Impact Factor

One quarter of total myocardial infarctions are silent manifestation in patients with type 2 diabetes mellitus.

J Cardiol 2019 Jan 4;73(1):33-37. Epub 2018 Jul 4.

Department of Cardiovascular Medicine, Nara Medical University, Kashihara, Japan.

Background: Silent events with newly developed Q waves in electrocardiogram (ECG) [silent myocardial infarction (MI)] in diabetic patients is reported to be independently associated with an increased risk of fatal MI. However, the incidence rate of silent MI in diabetic patients has yet to be clarified. We sought to determine the incidence rate of first symptomatic MI and silent MI in diabetic patients. Read More

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January 2019

PCSK9 Inhibitor Therapy: A Systematic Review And Meta-Analysis of Metabolic And Cardiovascular Outcomes in Patients With Diabetes.

Diabetes Obes Metab 2018 Nov 28. Epub 2018 Nov 28.

Diabetology, Azienda Ospedaliero-Universitaria Careggi and University of Florence, Florence, Italy.

Aim: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors determine a wide reduction of LDL cholesterol, greater than other lipid-lowering agents. Aim of this metanalysis was the assessment of PCSK9 inhibitors effects on glucose metabolism, LDL-cholesterol, cardiovascular morbidity and mortality in patients with and without diabetes.

Methods: A Medline and Clinicaltrials. Read More

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November 2018
4 Reads

Cosyntropin testing does not predict response to glucocorticoids in community-acquired pneumonia in a randomized controlled trial.

Clin Endocrinol (Oxf) 2018 Nov 28. Epub 2018 Nov 28.

Endocrinology, Diabetology and Metabolism, Department of Internal Medicine and Department of Clinical Research, University Hospital Basel, 4031, Basel, Switzerland.

Objective: Glucocorticoids have been shown to improve outcome in community-acquired pneumonia (CAP). However, glucocorticoids have potential side-effects, and treatment response may vary. It is thus crucial to select patients with high likelihood to respond favorably. Read More

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November 2018
1 Read

A head-to-head comparison of personal and professional continuous glucose monitoring systems in people with type 1 diabetes: hypoglycaemia remains the weak spot.

Diabetes Obes Metab 2018 Nov 28. Epub 2018 Nov 28.

Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

To compare the performance of a professional (proCGM) and a personal continuous glucose monitoring (persCGM) system worn in parallel under standardised conditions in individuals with type 1 diabetes (T1D). Two CGM systems (iPro2 - proCGM; Minimed 640G - persCGM) worn in parallel using the same sensor (Enlite 2) were compared. Ten people with T1D were included in this single-centre, open-label study in which CGM performance was evaluated. Read More

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November 2018

The Effect of Linagliptin versus Metformin Treatment-Related Quality of Life in Patients with Type 2 Diabetes Mellitus.

Diabetes Ther 2018 Nov 27. Epub 2018 Nov 27.

Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan.

Introduction: There have been no studies directly comparing the effect of dipeptidyl peptidase-4 inhibitors with that of metformin on treatment-related quality of life (QOL) when used as first-line therapy in patients with type 2 diabetes mellitus (T2DM).

Methods: This study is a prospective, randomized, open-label, multicenter, parallel-group, comparative study. Forty-four participants who failed to achieve target glycemic control with diet and exercise therapy were randomly allocated to receive linagliptin or metformin therapy. Read More

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November 2018

Trends and cyclical variation in the incidence of childhood type 1 diabetes in 26 European centres in the 25 year period 1989-2013: a multicentre prospective registration study.

Diabetologia 2018 Nov 28. Epub 2018 Nov 28.

Odense Patient data Exploratory Network (OPEN), Odense University Hospital/Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

Aims/hypothesis: Against a background of a near-universally increasing incidence of childhood type 1 diabetes, recent reports from some countries suggest a slowing in this increase. Occasional reports also describe cyclical variations in incidence, with periodicities of between 4 and 6 years.

Methods: Age/sex-standardised incidence rates for the 0- to 14-year-old age group are reported for 26 European centres (representing 22 countries) that have registered newly diagnosed individuals in geographically defined regions for up to 25 years during the period 1989-2013. Read More

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November 2018

Plasma steroid metabolome profiling for the diagnosis of adrenocortical carcinoma.

Eur J Endocrinol 2018 Nov 1. Epub 2018 Nov 1.

M Kroiss, Department of Internal Medicine I, Division of Endocrinology and Diabetology, University Hospital Würzburg, Würzburg, Germany.

Objective: Current workup for the pre-operative distinction between frequent adrenocortical adenomas (ACA) and rare but aggressive adrenocortical carcinomas (ACC) combines imaging and biochemical testing. We here investigated the potential of plasma steroid hormone profiling by liquid chromatography tandem mass spectrometry (LC-MS/MS) for the diagnosis of malignancy in adrenocortical tumours.

Design: Retrospective cohort study of prospectively collected EDTA-plasma samples in a single tertiary reference center. Read More

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November 2018

The association of thyroid-stimulating hormone (TSH) and free thyroxine (fT4) concentration levels with carbohydrate and lipid metabolism in obese and overweight teenagers.

Endokrynol Pol 2018 Nov 27. Epub 2018 Nov 27.

Medical University of Gdansk, Department of Pediatrics, Diabetology and Endocrinology, ul Dębinki 7, 80-292 Gdańsk, Poland.

Introduction: Obesity has increased rapidly among children and adolescents during the last 30 years. Pediatric patients with a BMI >85th centile are more often diagnosed with increased TSH levels than children with proper body weight.

Materials And Methods: The data of 961 overweight and obese children, aged 13, recruited in four cities in Poland as part of PoZdro!, a two-year prophylactic program, were analysed to observe the relationship between serum TSH and fT4 concentration and carbohydrate and lipid metabolism parameters, as well as anthropometric parameters. Read More

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November 2018
4 Reads

Effect of growth hormone treatment on energy expenditure and its relation to first-year growth response in children.

Eur J Appl Physiol 2018 Nov 26. Epub 2018 Nov 26.

Department of Paediatric Endocrinology, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.

Purpose: The effects of growth hormone (GH) treatment on linear growth and body composition have been studied extensively. Little is known about the GH effect on energy expenditure (EE). The aim of this study was to investigate the effects of GH treatment on EE in children, and to study whether the changes in EE can predict the height gain after 1 year. Read More

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November 2018
1 Read

Content-aware image restoration: pushing the limits of fluorescence microscopy.

Nat Methods 2018 Nov 26. Epub 2018 Nov 26.

Center for Systems Biology Dresden, Dresden, Germany.

Fluorescence microscopy is a key driver of discoveries in the life sciences, with observable phenomena being limited by the optics of the microscope, the chemistry of the fluorophores, and the maximum photon exposure tolerated by the sample. These limits necessitate trade-offs between imaging speed, spatial resolution, light exposure, and imaging depth. In this work we show how content-aware image restoration based on deep learning extends the range of biological phenomena observable by microscopy. Read More

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November 2018

In-and-Out Molecular Changes Linked to the Type 2 Diabetes Remission after Bariatric Surgery: An Influence of Gut Microbes on Mitochondria Metabolism.

Int J Mol Sci 2018 Nov 24;19(12). Epub 2018 Nov 24.

Clinical Research Centre, Medical University of Bialystok, 15-276 Bialystok, Poland.

Different kinds of gastrointestinal tract modulations known as "bariatric surgery" are actually the most effective treatment for obesity and associated co-morbidities, such as type 2 diabetes (T2DM). The potential causes of those effects have yet to be explained. In our study, we focused on molecular changes evoked by laparoscopic sleeve gastrectomy leading to T2DM remission. Read More

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November 2018
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Development of the Metabolic Syndrome: Study Design and Baseline Data of the Lufthansa Prevention Study (LUPS), A Prospective Observational Cohort Survey.

Exp Clin Endocrinol Diabetes 2018 Nov 26. Epub 2018 Nov 26.

Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

The (LUPS) study is a prospective observation of a healthy worker cohort to identify early changes in metabolism leading to the Metabolic Syndrome (MetS) and to analyze their relation to behavioral factors like nutrition, physical activity, psychological status, and to underlying genetic conditions. The LUPS study recruited a sample of 1.962 non-diabetic healthy adults between 25-60 years, employed at a flight base of Lufthansa Technik GmbH in Hamburg, Germany. Read More

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November 2018
3 Reads

Detection of recombinant and endogenous mouse melatonin receptors by monoclonal antibodies targeting the C-terminal domain.

J Pineal Res 2018 Nov 26:e12540. Epub 2018 Nov 26.

Inserm, U1016, Institut Cochin, Paris, France.

Melatonin receptors play important roles in the regulation of circadian and seasonal rhythms, sleep, retinal functions, the immune system, depression and type 2 diabetes development. Melatonin receptors are approved drug targets for insomnia, non-24h sleep-wake disorders and major depressive disorders. In mammals, two melatonin receptors (MTRs) exist, MT and MT , belonging to the G protein-coupled receptor (GPCR) super-family. Read More

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November 2018
1 Read

Periostin concentrations in childhood-onset craniopharyngioma patients.

J Endocrinol Invest 2018 Nov 24. Epub 2018 Nov 24.

Department of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Klinikum Oldenburg AöR, 26133, Oldenburg, Germany.

Purpose: Periostin is highly expressed in craniopharyngioma (CP)-associated fibroblasts and has been identified as a marker for non-alcoholic fatty liver disease (NAFLD). Half of CP patients with hypothalamic syndrome develop NAFLD. We hypothesized that periostin concentration is elevated in biological fluids of CP and associated with pathological hepatic parameters, indicating increased risk for NAFLD. Read More

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November 2018
2 Reads

Reply to Gaertner, K. and Frass, M.

Acta Diabetol 2018 Nov 24. Epub 2018 Nov 24.

Diabetology, Azienda Ospedaliero-Universitaria Careggi and University of Florence, Florence, Italy.

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November 2018

Development of a research agenda for general practice based on knowledge gaps identified in Dutch guidelines and input from 48 stakeholders.

Eur J Gen Pract 2018 Nov 26:1-6. Epub 2018 Nov 26.

a Department of Family Medicine, Care and Public Health Research Institute (CAPHRI) , Maastricht University , Maastricht , The Netherlands.

Background: Several funding organizations using different agendas support research in general practice. Topic selection and prioritization are often not coordinated, which may lead to duplication and research waste.

Objectives: To develop systematically a national research agenda for general practice involving general practitioners, researchers, patients and other relevant stakeholders in healthcare. Read More

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November 2018

Sarcopenia in patients with non-alcoholic fatty liver disease: is it a clinically significant entity?

Obes Rev 2018 Nov 25. Epub 2018 Nov 25.

Laboratory of Experimental Medicine and Paediatrics (LEMP), University of Antwerp, Wilrijk (Antwerp), Belgium.

Sarcopenia, described as the loss of muscle mass and/or strength, is gaining importance as it can be increasingly related to many chronic diseases. It is also associated with chronic liver disease, and recently it has been more frequently linked to non-alcoholic fatty liver disease (NAFLD) in particular. Both sarcopenia and NAFLD are subject to complex and intermingled pathophysiological processes, of which some are in common. Read More

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November 2018
3 Reads

Does Home-Based Progressive Resistance or High-Intensity Circuit Training Improve Strength, Function, Activity or Participation in Children With Cerebral Palsy?

Arch Phys Med Rehabil 2018 Dec 4;99(12):2457-2464.e4. Epub 2018 Jul 4.

Paediatric Orthopaedic Unit, Department of Paediatric Surgery, Medical University of Graz, Graz, Austria.

Objective: Does home-based progressive resistance or high-intensity circuit training improve strength, function, activity, or participation in children with cerebral palsy (CP)?

Design: This was the first study on high-intensity circuit training for children with CP. This study was conducted as a randomized prospective controlled pilot study.

Setting: Evaluation took place at the gait laboratory of the university hospital, training sessions were performed at home. Read More

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December 2018
3 Reads

Role of DNA repair genes XRCC3 and XRCC1 in predisposition to type 2 diabetes mellitus and diabetic nephropathy.

Endocrinol Diabetes Nutr 2018 Nov 21. Epub 2018 Nov 21.

Istinye University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Istanbul, Turkey.

Introduction: Increasing number of experimental and clinical studies suggest a strong relationship between hyperglycemia, oxidative stress, DNA damage and diabetic nephropathy (DN). Also, epidemiologic studies remark an enhanced risk of cancer with type 2 diabetes. This research aims to assess whether the X-ray cross complementing group 3 (XRCC3) gene T241M polymorphism (rs861539) and X-ray cross complementing group 1 (XRCC1) gene A399G polymorphism (rs25487) are related with predisposition to type 2 diabetes mellitus (T2DM) and to diabetic nephropathy in Turkish population. Read More

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November 2018

Acid-base and electrolyte disturbances in patients with diabetes mellitus.

Acta Clin Belg 2018 Nov 23:1-6. Epub 2018 Nov 23.

a Departments of Nephrology , Universitair Ziekenhuis Brussel , Brussels , Belgium.

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November 2018
1 Read

Bile acids and glucocorticoid metabolism in health and disease.

Biochim Biophys Acta Mol Basis Dis 2019 Jan 3;1865(1):243-251. Epub 2018 Aug 3.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria. Electronic address:

Glucocorticoids are regulators of stress response essential for survival. Liver disease can alter this homeostatic mechanism in patients with liver cirrhosis - a finding that might mirror the controversially discussed condition of critical illness related corticosteroid insufficiency. Underlying mechanisms might be shared molecular pathways in both bile acid as well as glucocorticoid metabolism at the level of synthesis, catabolism or the hypothalamus and the pituitary gland. Read More

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January 2019
4 Reads

Unrecognised cardiovascular disease in type 2 diabetes: is it time to act earlier?

Cardiovasc Diabetol 2018 Nov 21;17(1):145. Epub 2018 Nov 21.

Department of Endocrinology and Metabolic Diseases, Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, Merkur University Hospital, School of Medicine, Endocrinology and Metabolic Diseases, University of Zagreb, Zagreb, Croatia.

Cardiovascular disease (CVD) is the most significant prognostic factor in individuals with type 2 diabetes (T2D). However, a significant number of individuals may develop CVD that does not present with the classic angina-related or heart failure symptoms. In these cases, CVD may seem to be 'silent' or 'asymptomatic', but may be more accurately characterised as unrecognised diabetic cardiac impairment. Read More

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November 2018
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Influence of outdoor temperature and relative humidity on incidence and etiology of hyponatremia.

J Clin Endocrinol Metab 2018 Nov 19. Epub 2018 Nov 19.

Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland.

Context: Hyponatremia is the most common electrolyte disturbance in hospitalized patients. Known risk factors are heart or renal failure, excessive drinking or the use of diuretics. The incidence of hyponatremia may also be influenced by climate. Read More

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November 2018
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Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial.

Eur J Nutr 2018 Nov 20. Epub 2018 Nov 20.

Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.

Purpose: It has been hypothesized that vitamin D is associated with androgen levels in men. We, therefore, aimed to evaluate whether vitamin D supplementation increases serum total testosterone (TT) levels in men with low TT levels at baseline.

Methods: The Graz Vitamin D&TT-RCT is a single-center, double-blind, randomized placebo-controlled trial conducted between March 2013 and November 2017 at the endocrine outpatient clinic at the Medical University of Graz, Austria. Read More

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November 2018
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Recurrent tendosynovitis as a rare manifestation of a lipid disorder.

J Clin Lipidol 2018 Oct 24. Epub 2018 Oct 24.

Department of Internal Medicine V (Nephrology, Rheumatology, Hypertensiology, Endocrinolgy, Diabetology), Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany; Mannheim Institute of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany. Electronic address:

A 33-year-old female had suffered from spontaneously recurrent bursitis and tendosynovitis/enthesitis of the patellar and Achilles tendons for about 10 years. The episodes of immobilization increased. Ultrasound imaging of the swollen and painful tendons showed chronic inflammation with neoangiogenesis within the tendons and hypoechoic lesions. Read More

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October 2018
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Healthcare professionals' perceptions and perspectives on biosimilar medicines and the barriers and facilitators to their prescribing in UK: a qualitative study.

BMJ Open 2018 Nov 18;8(11):e023603. Epub 2018 Nov 18.

School of Pharmacy, Keele University, Newcastle-Under-Lyme, UK.

Objective: To investigate UK healthcare professionals' perceptions and perspectives towards biosimilar infliximab, etanercept and insulin glargine and the potential barriers and facilitators to their prescribing.

Design: A cross-sectional qualitative study design was used.

Setting: Five hospitals within the West Midlands area in UK. Read More

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November 2018
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