7,190 results match your criteria Diabetology & Metabolic Syndrome [Journal]


Diabetic Hypoglycaemia during Ramadan Fasting: A Trans-National Observational Real-World Study.

Diabetes Res Clin Pract 2019 Feb 14. Epub 2019 Feb 14.

Diabetes Unit, Amiri Hospital, Ministry of Health, Kuwait City, Kuwait. Electronic address:

Objectives: To describe the risk of hypoglycaemia during Ramadan and determine its risk factors, and the impact of hypoglycaemia on patients' behaviour.

Methods: A cross-sectional multi-country observational study, with data captured within 6 weeks after Ramadan 2015. Patients' and disease characteristics and its management, the risk of hypoglycaemia and patients' response to hypoglycaemia were recorded RESULTS: A cohort of 1759 patients; majority with type 2 diabetes mellitus from North Africa, Arabian Gulf, Saudi Arabia, and the Indian subcontinent. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.039DOI Listing
February 2019

The effect of L-theanine supplementation on the immune system of athletes exposed to strenuous physical exercise.

J Int Soc Sports Nutr 2019 Feb 15;16(1). Epub 2019 Feb 15.

Department of Morphological and Health Sciences, Faculty of Physical Culture in Gorzów Wielkopolski, 13 Estkowskiego Str, 66-400, Gorzów Wielkopolski, Poland.

Background: The aim of this study was to analyze the response of selected components of the immune system in rowers to maximal physical exercise, and to verify if this response could be modulated by supplementation with L-theanine.

Method: The double-blind study included 20 members of the Polish Rowing Team. The subjects were randomly assigned to the supplemented group (n = 10), receiving 150 mg of L-theanine extract for 6 weeks, or to the placebo group (n = 10). Read More

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http://dx.doi.org/10.1186/s12970-019-0274-yDOI Listing
February 2019

Assessment of optimal insulin administration timing for standard carbohydrates rich meals using continuous glucose monitoring in children with type 1 diabetes-crossover randomized study.

J Diabetes Investig 2019 Feb 15. Epub 2019 Feb 15.

Department of Children's Diabetology, Medical University Of Silesia, Katowice, Poland.

Objective: Assessment of postprandial glucose concentration after carbohydrates rich meals using continuous glucose monitoring in 30 children with type 1 diabetes treated using continuous subcutaneous insulin infusion with a rapid-acting analogs insulin.

Methods: During 3 days, participants administering simple boluses with different delay time between insulin administration and beginning of carbohydrates rich meals consumption (meal №1 containing - 197 kcal, №2 - 247 kcal and meal №3 - 323 kcal; practically not containing protein and fat). In our cross-over randomized study we analyzed: average glucose concentration profiles in 5-minutes intervals, mean glucose at insulin administration, after 120 and 180 minutes, mean and peak glucose, glucose peak time, areas under glucose and glucose increase curves, time period lengths with glucose below 50, 70 mg/dl and over 140, 200 mg/dl. Read More

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http://dx.doi.org/10.1111/jdi.13027DOI Listing
February 2019

Impact of multidisciplinary foot care team on outcome of diabetic foot ulcer in term of lower extremity amputation at a tertiary care unit in Karachi, Pakistan.

Int Wound J 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi, Pakistan.

To compare the outcomes of diabetic foot ulcers (DFU) in terms of healing and lower extremity amputation (LEA) rate before and after training of multidisciplinary foot care team (MDFCT). Subjects were categorised into two groups; Group-A cases seen between 1997 and 2006 (before upgrading of training and services of MDFCT) and Group-B cases seen between 2007 and 2016 (after upgrading of training and services of MDFCT). Baseline demographic characteristics, biochemical results, and outcomes of DFU in terms of healing or amputation were analysed by using statistical package social science (SPSS) version 20. Read More

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http://dx.doi.org/10.1111/iwj.13095DOI Listing
February 2019

Rates of Hypoglycemia Predicted in Patients with Type 2 Diabetes on Insulin Glargine 300 U/ml Versus First- and Second-Generation Basal Insulin Analogs: The Real-World LIGHTNING Study.

Diabetes Ther 2019 Feb 14. Epub 2019 Feb 14.

Division of Endocrinology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Introduction: The LIGHTNING study applied conventional and advanced analytic approaches to model, predict, and compare hypoglycemia rates of people with type 2 diabetes (T2DM) on insulin glargine 300 U/ml (Gla-300) with those on first-generation (insulin glargine 100 U/ml [Gla-100]; insulin detemir [IDet]) or second-generation (insulin degludec [IDeg]) basal-insulin (BI) analogs, utilizing a large real-world database.

Methods: Data were collected between 1 January 2007 and 31 March 2017 from the Optum Humedica US electronic health records [EHR] database. Patient-treatments, the period during which a patient used a specific BI, were analyzed for patients who switched from a prior BI or those who newly initiated BI therapy. Read More

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http://dx.doi.org/10.1007/s13300-019-0568-8DOI Listing
February 2019

Flash Glucose Monitoring in Subjects with Diabetes on Hemodialysis: A Pilot Study.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):848-851

Department of Clinical Diabetology and Endocrinology, Chellaram Diabetes Institute, Pune, Maharashtra, India.

Background: In patients with diabetes related end-stage renal disease (ESRD) on hemodialysis, blood glucose management can be challenging due to the kinetics of glucose and insulin in addition to other factors. The glucose monitoring systems which measure glucose levels continuously may be useful to study the glucose profile of patients with diabetes undergoing hemodialysis. Our study is designed to use ambulatory glucose profile to study the glucose pattern - during, before, and after a session of hemodialysis. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_520_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330844PMC
February 2019

High-resolution respirometry in human endomyocardial biopsies shows reduced ventricular oxidative capacity related to heart failure.

Exp Mol Med 2019 Feb 14;51(2):16. Epub 2019 Feb 14.

Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Heinrich Heine University, Düsseldorf, Germany.

The lifetime risk of developing heart failure is approximately 20%, and survival rates remain poor. Myocardial mitochondrial function has been suggested to play a pivotal role in heart failure pathophysiology. Human studies on ex vivo mitochondrial function have mostly been limited to atrial tissue obtained during open heart surgery and have provided contradictory results. Read More

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http://dx.doi.org/10.1038/s12276-019-0214-6DOI Listing
February 2019

Update on central precocious puberty: from etiologies to outcomes.

Expert Rev Endocrinol Metab 2019 Feb 12:1-8. Epub 2019 Feb 12.

b Department of Pediatrics/Division of Pediatric Endocrinology and Diabetology , Riley Hospital for Children, Indiana University School of Medicine , Indianapolis , IN , USA.

Introduction: Precocious puberty (PP) is one of the most common reasons for referral to pediatric endocrinologists. Gonadotropin-releasing hormone analogs (GnRHas) are the gold standard for the treatment of central precocious puberty (CPP) and have an impressive record of safety and efficacy. However, ongoing refinements in diagnosis and management continue to lead to important advancements in clinical care. Read More

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http://dx.doi.org/10.1080/17446651.2019.1575726DOI Listing
February 2019

Effects of PCSK9 inhibitors on LDL cholesterol, cardiovascular morbidity and all-cause mortality: a systematic review and meta-analysis of randomized controlled trials.

J Endocrinol Invest 2019 Feb 14. Epub 2019 Feb 14.

Diabetology, Azienda Ospedaliero-Universitaria Careggi and University of Florence, Largo Brambilla 32, 50139, Florence, Italy.

Background And Aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors determine a wide reduction of LDL cholesterol, greater than other lipid-lowering agents. The present meta-analysis is aimed at the assessment of PCSK9 inhibitors effect on LDL Cholesterol, cardiovascular morbidity and all-cause mortality.

Methods And Results: A Medline and Clinicaltrials. Read More

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http://dx.doi.org/10.1007/s40618-019-01019-4DOI Listing
February 2019

Review of Leipzig protocol for intravenous insulin infusion in pediatric patients with type 1 diabetes during intercurrent illness and surgery.

Pediatr Diabetes 2019 Feb 13. Epub 2019 Feb 13.

Department of Endocrinology and Diabetology, University of Leipzig, Hospital for Children and Adolescents, 04103 Leipzig, Sachsen, Germany.

Objective: Continuous intravenous (IV) insulin infusion therapy minimizes blood glucose (BG) fluctuations and prevents metabolic deterioration in pediatric patients with type 1 diabetes (T1D) during intercurrent illness and surgery. However, data on the adequate fluid and insulin substitution in this situation is rare. We evaluated the effectiveness and safety of IV insulin therapy according to our local protocol. Read More

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http://dx.doi.org/10.1111/pedi.12830DOI Listing
February 2019

Characteristics of CF-related Diabetes: Data from Two Different Sources the ECFS Patient Registry and the DPV Registry.

Pediatr Diabetes 2019 Feb 13. Epub 2019 Feb 13.

Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology, University of Ulm, 89081 Ulm, Germany.

Background: Standardized patient registries provide a unique basis to get insight into cystic fibrosis-related diabetes (CFRD), the most common comorbidity in cystic fibrosis.

Methods: 3,853 CFRD patients from the European CF Society Patient Registry (ECFSPR) and 752 from the German/Austrian diabetes prospective follow-up (DPV) were studied. To adjust for age and sex, multivariable regression was used (SAS 9. Read More

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http://dx.doi.org/10.1111/pedi.12831DOI Listing
February 2019

Impact of diverse chemotherapeutic agents and external factors on activation of brown adipose tissue in a large patient collective.

Sci Rep 2019 Feb 13;9(1):1901. Epub 2019 Feb 13.

Diagnostic and Interventional Radiology, Department of Radiology, Eberhard Karls University, Hoppe-Seyler-Straße 3, 72076, Tuebingen, Germany.

Increased activity of brown adipose tissue (BAT) activity in adults is thought to prevent obesity. Therefore, regulators of BAT activity might serve as anti-obesity therapy in future, but are not investigated thoroughly up to now. In our study, we assessed retrospectively the association of BAT activity with several external factors and diverse chemotherapeutic and immunosuppressive agents in a collective of 702 patients. Read More

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http://dx.doi.org/10.1038/s41598-018-37924-6DOI Listing
February 2019

Systematic thyroid screening in myotonic dystrophy: link between thyroid volume and insulin resistance.

Orphanet J Rare Dis 2019 Feb 13;14(1):42. Epub 2019 Feb 13.

CHU Lille, Endocrinology, Diabetology and Metabolism, F-59000, Lille, France.

Background: Myotonic dystrophy (DM1), a neuromuscular disease related to DMPK gene mutations, is associated to endocrine disorders and cancer. A routine endocrine work-up, including thyroid ultrasound (US), was conducted in 115 genetically-proven DM1 patients in a neuromuscular reference center. The aim of this study was to determine the prevalence and the causes of US thyroid abnormalities in DM1. Read More

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http://dx.doi.org/10.1186/s13023-019-1019-3DOI Listing
February 2019

Exenatide once-weekly improves metabolic parameters, endothelial dysfunction and carotid intima-media thickness in patients with type-2 diabetes: an 8-month prospective study.

Diabetes Res Clin Pract 2019 Feb 10. Epub 2019 Feb 10.

Biomedical Department of Internal Medicine and Specialties, University of Palermo, Italy; Division of Endocrinology, Diabetes and Metabolism, University of South Carolina School of Medicine, Columbia, South Carolina, USA.

Aim: To evaluate the effect of exenatide long acting release (LAR) on carotid intima-media thickness (IMT) and endothelial function in patients with type 2 diabetes mellitus.

Methods: Sixty subjects with type 2 diabetes mellitus were treated with exenatide LAR as add-on to stable doses of metformin for 8 months in an open label study. Anthropometric variables, lipid profile and glycemic parameters were assessed by routine analysis. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.02.006DOI Listing
February 2019
2 Reads

The anti-vaccine movement in Poland: The socio-cultural conditions of the opposition to vaccination and threats to public health.

Vaccine 2019 Feb 9. Epub 2019 Feb 9.

Department of Endocrinology, Diabetology and Metabolic Diseases of the 4th Military Clinical Hospital, Poland. Electronic address:

The article analyses the cultural and political contexts of the revival of the anti-vaccine movement in Poland. According to the authors, the attempt to institutionalise and politicise anti-vaccine activists is part of the wider phenomenon of political populism in Eastern Europe. The attempt to abolish compulsory vaccinations, which is supported by right-wing populists, shows that the anti-Enlightenment and anti-Western shift in the public sphere in Eastern Europe can also affect the area of health protection. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.073DOI Listing
February 2019

STEP as a Useful Tool to Screen for Diabetes-Specific Health-Related Problems in Community-Based Geriatric Patients- An Exploratory Secondary Analysis of Cross-Sectional Data.

Exp Clin Endocrinol Diabetes 2019 Feb 12. Epub 2019 Feb 12.

Institute of General Practice and Family Medicine, Medical Faculty of Martin-Luther-University Halle-Wittenberg, Halle, Germany.

Background And Aims: Comprehensive geriatric assessments are established tools for the identification of health problems in the elderly. So far, little is known about tailoring and targeting to facilitate their application. As a starting point for a tailored assessment of patients with diabetes, a highly prevalent health condition, we aimed to assess if the Standardized Assessment of Elderly People (STEP) is able to identify relevant differences in self-reported health problems between diabetic and non-diabetic patients. Read More

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http://dx.doi.org/10.1055/a-0803-0362DOI Listing
February 2019
2 Reads

Functional hypothalamic and drug-induced amenorrhea: an overview.

J Endocrinol Invest 2019 Feb 11. Epub 2019 Feb 11.

University of Ferrara, Ferrara, Italy.

Background: Functional hypothalamic amenorrhea (FHA) is a form of chronic anovulation not due to identifiable organic causes and with adverse health consequences. The identification of women with this disorder or the precocious identification of women at risk is based on the knowledge of lifestyle risk factors or behaviors such as stress, weight loss, and excessive physical exercise that are known to negatively impact gonadal axis activity.

Methods: In this overview, we described the most common forms of FHA, in particular stress-induced amenorrhea and overtraining-induced amenorrhea. Read More

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http://dx.doi.org/10.1007/s40618-019-01013-wDOI Listing
February 2019
1 Read

Augmented contractility of murine femoral arteries in a streptozotocin diabetes model is related to increased phosphorylation of MYPT1.

Physiol Rep 2019 Feb;7(3):e13975

Institute of Vegetative Physiology, University of Cologne, Köln, Germany.

Diabetes mellitus (DM) is a metabolic disorder with high prevalence, and a major risk factor for macro- and microvascular abnormalities. This study was undertaken to explore the mechanisms of hypercontractility of murine femoral arteries (FA) obtained from mice with streptozotocin (STZ)-induced diabetes and its relation to the phosphorylation profile of the myosin phosphatase target subunit 1, MYPT1. The immunoreactivity of MYPT1 toward phospho-MYPT1-T696, MYPT1-T853, or MYPT1-S695, used as a read out for MYPT1 phosphorylation, has been studied by Western Blotting. Read More

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http://dx.doi.org/10.14814/phy2.13975DOI Listing
February 2019

International clinical guidelines for the management of phosphomannomutase 2-congenital disorders of glycosylation: Diagnosis, treatment and follow up.

J Inherit Metab Dis 2019 Jan;42(1):5-28

Department of Clinical Genomics, Mayo Clinic, Rochester, New York.

Phosphomannomutase 2 (PMM2-CDG) is the most common congenital disorder of N-glycosylation and is caused by a deficient PMM2 activity. The clinical presentation and the onset of PMM2-CDG vary among affected individuals ranging from a severe antenatal presentation with multisystem involvement to mild adulthood presentation limited to minor neurological involvement. Management of affected patients requires a multidisciplinary approach. Read More

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http://dx.doi.org/10.1002/jimd.12024DOI Listing
January 2019
1 Read

Long-term effect of pioglitazone vs glimepiride on lipoprotein oxidation in patients with type 2 diabetes: a prospective randomized study.

Acta Diabetol 2019 Feb 10. Epub 2019 Feb 10.

Diabetology and Dietetics, Department of Medicine (DIMED), University of Padova, via Giustiniani, 2, 35100, Padua, Italy.

Aims: Type 2 diabetes (DM2) is associated to oxidative modifications of high-density lipoproteins (HDL), which can interfere with their function. Pioglitazone has proved effective in raising HDL cholesterol (HDL-C) and lowering small dense low-density lipoprotein (LDL), but no clinical studies have examined its effect on lipoprotein oxidation in patients with DM2.

Methods: We assessed the effect of pioglitazone vs glimepiride after 1 year on HDL oxidation, expressed as relative abundance of peptides containing MetO in ApoA-I (oxApoA-I) estimated by mass spectrometry (MALDI/TOF/TOF), in 95 patients with DM2. Read More

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http://dx.doi.org/10.1007/s00592-018-01278-2DOI Listing
February 2019

Growth impairment and limited range of joint motion in children should raise suspicion of an attenuated form of mucopolysaccharidosis: expert opinion.

Eur J Pediatr 2019 Feb 11. Epub 2019 Feb 11.

Groupe de Pédiatrie Générale - Société Française de Pédiatrie, Boulogne-Billancourt, Department of Pediatrics and Pediatric Emergency, Ambroise-Paré Hospital, Boulogne-Billancourt, France.

Growth impairment together with bone and joint involvement is common to most patients with mucopolysaccharidosis (MPS) disorders. The genetic basis for these metabolic disorders involves various enzyme deficiencies responsible for the catabolism of glycosaminoglycans (GAGs). The incomplete degradation and subsequent accumulation of GAGs result in progressive tissue damage throughout the body. Read More

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http://dx.doi.org/10.1007/s00431-019-03330-xDOI Listing
February 2019

Vitamin D Supplementation and Physical Activity of Young Soccer Players during High-Intensity Training.

Nutrients 2019 Feb 6;11(2). Epub 2019 Feb 6.

Department of Health Promotion, Gdansk University of Physical Education and Sport, 80-336 Gdańsk, Poland.

The aim of this study was to confirm that vitamin D supplementation of young soccer players during eight-week high-intensity training would have a significant effect on their motion activity. The subjects were divided into two groups: the experimental one, which was supplemented with vitamin D (SG, = 20), and the placebo group (PG, = 16), which was not supplemented with vitamin D. All the players were subjected to the same soccer training, described as High-Intensity Interval Training (HIIT). Read More

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http://dx.doi.org/10.3390/nu11020349DOI Listing
February 2019
1 Read

Differential expression of estrogen receptor-α on follicular dendritic cells from patients with grade 1-2 and grade 3 follicular lymphoma.

Hematol Oncol 2019 Feb 8. Epub 2019 Feb 8.

Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan.

Hormone therapy has been used for patients with estrogen receptor alpha (ERα)-positive breast cancers. Recently, some studies reported the expression of ERα on neoplastic cells from B cell lymphomas. However, there has been only one report of ERα expression on the follicular dendritic cells (FDCs) that structurally and functionally support the microenvironment of follicular lymphomas (FLs). Read More

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http://dx.doi.org/10.1002/hon.2577DOI Listing
February 2019
1 Read

Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial.

Food Chem Toxicol 2019 Feb 5;126:1-6. Epub 2019 Feb 5.

Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Lausanne, Switzerland. Electronic address:

Sulforaphane is a redox-active natural product present in cruciferous vegetables like broccoli. Broccoli sprout-derived products are promising agents for the prevention of oxidative stress-related diseases, but some have long been suspected of thyroidal toxicity. Recent findings also raise the possibility that long-term exposure to sulforaphane, or to other natural substances or drugs that modulate the activity of the transcription factor Nrf2 (NFE2-related factor 2) may lead to thyroid dysfunction or thyroid autoimmune disease, questioning the safety of trials with sulforaphane-containing products. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.004DOI Listing
February 2019
1 Read

Diagnostic Accuracy of Glycated Haemoglobin and Average Glucose Values in Type 2 Diabetes Mellitus Treated with Premixed Insulin.

Diabetes Ther 2019 Feb 8. Epub 2019 Feb 8.

Department of Internal Diseases, Endocrinology and Diabetology, Central Clinical Hospital of the Ministry of the Inferior and Administration, Warsaw, Poland.

Introduction: Studies assessing the relationship between glycated haemoglobin (HbA1c) and average blood glucose (ABG) were conducted in small groups of patients on different treatments and may be biased for these reasons. The aim of the study was to assess the relationship between HbA1c and ABG in a large group of type 2 diabetes patients treated with premix insulin.

Methods: In 4257 patients treated with premixed insulin, the parallel point-of-care assessment of HbA1c and ABG from the preceding 90 days (ABG90), calculated automatically from all values measured by the glucometer, was performed twice. Read More

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http://dx.doi.org/10.1007/s13300-019-0570-1DOI Listing
February 2019
1 Read

The Influence of FTO Polymorphism rs9939609 on Obesity, Some Clinical Features, and Disturbance of Carbohydrate Metabolism in Patients with Psoriasis.

Biomed Res Int 2019 13;2019:7304345. Epub 2019 Jan 13.

Department and Clinic of Dermatology, Venereology and Allergology, Wroclaw Medical University, Poland.

Background: Psoriasis is often accompanied by obesity, hyperlipidemia, diabetes, and metabolic syndrome as risk factors of cardiovascular conditions and premature mortality.

Objective: The study was aimed at investigating whether psoriatic patients, who carry risk allele of obesity-related gene, are more predisposed to obesity and metabolic disturbances and whether it influences the severity of psoriasis.

Methods: 197 patients with psoriasis, representing Lower Silesia region of Poland, underwent physical examination and anthropometric measurements. Read More

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http://dx.doi.org/10.1155/2019/7304345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348832PMC
January 2019

Unrecognized Pseudohypoparathyroidism Type 1A as a Cause of Hypocalcemia and Seizures in a 64-Year-Old Woman.

Case Rep Endocrinol 2019 9;2019:8456239. Epub 2019 Jan 9.

Department of Health Sciences, University of Genoa; Medical Genetics Unit, Galliera Hospital, Genoa, Italy.

Pseudohypoparathyroidism type 1A (PHP1A) is usually diagnosed in childhood or early adulthood. We describe the case of a 64-year-old woman admitted to the Neurological Unit for recurrent episodes of loss of consciousness and seizures. Glycemia and ECG were normal, while hypocalcemia was noted. Read More

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http://dx.doi.org/10.1155/2019/8456239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343178PMC
January 2019
1 Read

International Consensus on Risk Management of Diabetic Ketoacidosis in Patients with Type 1 Diabetes Treated with Sodium-Glucose Cotransporter (SGLT) Inhibitors.

Diabetes Care 2019 Feb 6. Epub 2019 Feb 6.

Diabetes Centre for Children and Adolescents, AUF DER BULT, Kinder- und Jugendkrankenhaus, Hannover, Germany.

Sodium glucose cotransporter (SGLT) inhibitors are new oral antidiabetic medications shown to effectively reduce glycated hemoglobin (A1C) and glycemic variability, blood pressure and body weight without intrinsic properties to cause hypoglycemia in people with type 1 diabetes. However, recent studies, particularly in individuals with type 1 diabetes, have demonstrated increases in the absolute risk of diabetic ketoacidosis (DKA). Some cases presented with near-normal blood glucose levels or mild hyperglycemia, complicating the recognition/diagnosis of DKA and potentially delaying treatment. Read More

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-231
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http://dx.doi.org/10.2337/dc18-2316DOI Listing
February 2019
5 Reads

Serum 25-hydroxyvitamin D response to vitamin D supplementation in infants: a systematic review and meta-analysis of clinical intervention trials.

Eur J Nutr 2019 Feb 5. Epub 2019 Feb 5.

Department of Internal Medicine and Geriatrics, Bethel Clinic (EvKB), 33611, Bielefeld, Germany.

Purpose: For the prevention of nutritional rickets, 400 IU vitamin D daily and circulating 25-hydroxyvitamin D (25OHD) concentrations > 50 nmol/L are recommended, whereas the toxicity threshold is set at 250 nmol/L. We synthesized the evidence for the effect of vitamin D supplementation on incremental 25OHD in infants up to 1 year of age.

Methods: We performed a systematic review and meta-analysis of intervention trials in several databases. Read More

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http://dx.doi.org/10.1007/s00394-019-01912-xDOI Listing
February 2019

Oral Amoxicillin/Clavulanate for Treating Diabetic Foot Infections.

Diabetes Obes Metab 2019 Feb 5. Epub 2019 Feb 5.

Service of Infectious Diseases, Geneva University Hospitals, Geneva.

Some clinicians avoid amoxicillin-clavulanate (AMC) for the oral therapy of diabetic foot infections (DFI), especially for osteomyelitis (DFO), due to its poor bioavailability and bone penetration of all antibiotics from the β-lactam class. We performed a retrospective cohort analysis among 794 DFI episodes, including 339 DFO cases. The median duration of antibiotic therapy after surgical debridement (including partial amputation) was 30 days (DFO 30 days). Read More

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http://dx.doi.org/10.1111/dom.13651DOI Listing
February 2019
7 Reads
6.360 Impact Factor

Evaluation of Size and Location of a Mental Foramen in the Polish Population Using Cone-Beam Computed Tomography.

Biomed Res Int 2019 2;2019:1659476. Epub 2019 Jan 2.

Department of General Dentistry, Medical University of Lodz, Poland.

Introduction: The mental foramen (MF) is a bilateral opening localized on an anterior surface of the mandible. A precise location as well as well-defined shape, size, and number of the MF is crucial for different clinical dental procedures. The aim of this study was to determine a size and location of the MF in relation to the lower teeth using the cone-beam computed tomography (CBCT) study. Read More

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http://dx.doi.org/10.1155/2019/1659476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334310PMC
January 2019

Dypeptidylpeptidase-4 inhibitors and the cardiovascular system: How to manage the fil rouge.

Nutr Metab Cardiovasc Dis 2019 Jan 3. Epub 2019 Jan 3.

Diabetology, University of Florence, Italy. Electronic address:

Dypeptidylpeptidase-4 (DPP-4) inhibitors are a therapeutic option for improving glucose control in patients with type 2 diabetes. They can be prescribed at different stages of the natural history of the disease because of their low risk for hypoglycemia and associated weight gain. For all new drugs for diabetes, the US Food and Drug Administration requires the demonstration of the cardiovascular (CV) safety profile through pooled analyses of phase 3 studies or specifically designed trials. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09394753183036
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http://dx.doi.org/10.1016/j.numecd.2018.12.009DOI Listing
January 2019
3 Reads

Overall and disease-specific mortality in patients with Cushing's disease: a Swedish nationwide study.

J Clin Endocrinol Metab 2019 Feb 1. Epub 2019 Feb 1.

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg and The Department of Endocrinology, Sahlgrenska University Hospital, Göteborg, Sweden.

Context: It is still a matter of debate whether patients with Cushing's disease (CD) in remission have increased mortality.

Objective: To study overall and disease-specific mortality, and predictive factors, in an unselected nationwide cohort of patients with CD.

Design, Patients And Methods: A retrospective study on patients diagnosed with CD, identified in the Swedish National Patient Registry between 1987 and 2013. Read More

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http://dx.doi.org/10.1210/jc.2018-02524DOI Listing
February 2019
2 Reads

New data on antihypertensive drugs and risk of cancer: should we worry?

Blood Press 2019 Feb;28(1):1-3

d Vascular Biology and Hypertension Program, Department of Medicine , University of Alabama at Birmingham , AL , USA.

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http://dx.doi.org/10.1080/08037051.2019.1568182DOI Listing
February 2019

Remission phase in children diagnosed with type 1 diabetes (T1D) in years 2012-2013 in Silesia, Poland - an observational study.

Pediatr Diabetes 2019 Feb 3. Epub 2019 Feb 3.

Department of Children's Diabetology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Aim: The study aimed to analyze the frequency of partial remission (PR) and its association with chosen clinical and laboratory factors among pediatric patients with newly diagnosed type 1 diabetes (T1D). The long-term effect of PR on chosen parameters was also investigated.

Methods: In 194 patients (95 girls) aged 8. Read More

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http://dx.doi.org/10.1111/pedi.12824DOI Listing
February 2019

Variations of sex development: The first German interdisciplinary consensus paper.

J Pediatr Urol 2018 Nov 17. Epub 2018 Nov 17.

Institute for Sex Research and Forensic Psychiatry, University Medical Center, Hamburg-Eppendorf, Germany.

Introduction: The term variations of sex development subsumes a large number of congenital conditions including chromosomal mosaics and variations of chromosomal, gonadal, and phenotypic sex. A situation of this nature may cause severe distress to both, parents and affected persons. One of the reasons for this is the binary form of gender classification in the society. Read More

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http://dx.doi.org/10.1016/j.jpurol.2018.10.008DOI Listing
November 2018
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Prenatal maternal stress is associated with lower cortisol and cortisone levels in the first morning urine of 45-month-old children.

Psychoneuroendocrinology 2019 Jan 18;103:219-224. Epub 2019 Jan 18.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.

Prenatal stress (PS) has been related to altered hypothalamic-pituitary-adrenal (HPA) axis activity later in life. So far, studies in children assessing HPA axis functioning have focused on salivary cortisol, reflecting daytime activity. The present work is part of a prospective study and aims to extend knowledge about the association between PS and HPA axis regulation in children. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.01.017DOI Listing
January 2019
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Clinical features, biochemistry and HLA-DRB1 status in youth-onset type 1 diabetes in Pakistan.

Diabetes Res Clin Pract 2019 Jan 30;149:9-17. Epub 2019 Jan 30.

Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA. Electronic address:

Published information on diabetes in Pakistani youth is limited. We aimed to investigate the demographic, clinical, and biochemical features, and HLA-DRB1 alleles in new cases of diabetes affecting children and adolescents <22 years of age. The study was conducted at Baqai Institute of Diabetology and Endocrinology in Karachi from June 2013-December 2015. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183148
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http://dx.doi.org/10.1016/j.diabres.2019.01.023DOI Listing
January 2019
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Changes in the Use of Comprehensive Geriatric Assessment in Clinical Trials for Older Patients with Cancer over Time.

Oncologist 2019 Feb 1. Epub 2019 Feb 1.

Medical Oncology Department, Hospices Civils de Lyon (IC-HCL), Pierre-Bénite, France.

Background: The objective of this study was to describe the implementation of comprehensive geriatric assessment (CGA) in clinical trials dedicated to older patients before and after the creation of the International Society of Geriatric Oncology in the early 2000s.

Subjects, Materials, And Methods: All phase I, II, and III trials dedicated to the treatment of cancer among older patients published between 2001 and 2004 and between 2011 and 2014 were reviewed. We considered that a CGA was performed when the authors indicated an intention to do so in the Methods section of the article. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0493DOI Listing
February 2019

Accumulation of advanced glycation end products in the skin is accelerated in relation to insulin resistance in people with Type 1 diabetes mellitus.

Diabet Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan, Poland.

Aim: To evaluate the association between skin advanced glycation end products and insulin resistance in Type 1 diabetes.

Methods: The study group consisted of 476 people with Type 1 diabetes (247 men) with a median (interquartile range) age of 42 (33-53) years, disease duration of 24 (19-32) years and HbA concentration of 63 (55-74) mmol/mol [7.9 (7. Read More

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http://dx.doi.org/10.1111/dme.13921DOI Listing
February 2019

Pharmacokinetic and Pharmacodynamic Properties of L-Ornithine L-Aspartate (LOLA) in Hepatic Encephalopathy.

Drugs 2019 Jan 31. Epub 2019 Jan 31.

Department of Gastroenterology, Hepatology and Diabetology, Brandenburg Medical School, Center of Internal Medicine II, University Hospital Brandenburg, Hochstraße 29, 14770, Brandenburg an der Havel, Germany.

L-Ornithine L-aspartate (LOLA), a stable salt of L-ornithine and L-aspartate, readily dissociates into its constituent amino acids that are readily absorbed by active transport, distributed, and metabolized. L-ornithine serves as an intermediary in the urea cycle in periportal hepatocytes in the liver and as an activator of carbamoyl phosphate synthetase, and, like L-aspartate, by transamination to glutamate via glutamine synthetase in perivenous hepatocytes as well as by skeletal muscle and brain. By way of these metabolic pathways, both amino acids participate in reactions whereby the ammonia molecule is incorporated into urea and glutamine and it is the nature, cellular, and biological location of these pathways that underpins the application of LOLA as an effective ammonia-lowering strategy widely used for the management and treatment of hepatic encephalopathy. Read More

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http://dx.doi.org/10.1007/s40265-018-1023-2DOI Listing
January 2019
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Weaning practices in phenylketonuria vary between health professionals in Europe.

Mol Genet Metab Rep 2019 Mar 25;18:39-44. Epub 2018 Nov 25.

Birmingham Women's and Children's Hospital, Birmingham, UK.

Background: In phenylketonuria (PKU), weaning is considered more challenging when compared to feeding healthy infants. The primary aim of weaning is to gradually replace natural protein from breast milk or standard infant formula with solids containing equivalent phenylalanine (Phe). In addition, a Phe-free second stage L-amino acid supplement is usually recommended from around 6 months to replace Phe-free infant formula. Read More

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http://dx.doi.org/10.1016/j.ymgmr.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349955PMC
March 2019
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Cardiovascular risk algorithms in primary care: Results from the DETECT study.

Sci Rep 2019 Jan 31;9(1):1101. Epub 2019 Jan 31.

University of Heidelberg, Mannheim Medical Faculty, Department of Internal Medicine V (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Mannheim, Germany.

Guidelines for prevention of cardiovascular diseases use risk scores to guide the intensity of treatment. A comparison of these scores in a German population has not been performed. We have evaluated the correlation, discrimination and calibration of ten commonly used risk equations in primary care in 4044 participants of the DETECT (Diabetes and Cardiovascular Risk Evaluation: Targets and Essential Data for Commitment of Treatment) study. Read More

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http://dx.doi.org/10.1038/s41598-018-37092-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355969PMC
January 2019

In silico and functional studies reveal novel loss-of-function variants of SRD5A2, but no variants explaining excess 5α-reductase activity.

J Steroid Biochem Mol Biol 2019 Jan 28. Epub 2019 Jan 28.

Pediatric Endocrinology, Diabetology and Metabolism, Department of Pediatrics, University Hospital Inselspital, University of Bern, 3010 Bern, Switzerland; Department of BioMedical Research, University Hospital Inselspital, University of Bern, 3010 Bern, Switzerland. Electronic address:

Androgens are steroid hormones essential for human male and female development. Steroid reductases 5α (SRD5As) are key enzymes in androgen biosynthesis. Mutations in the human SRD5A2 are known to cause loss-of-function and severe 46,XY undervirilization. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09600760183058
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http://dx.doi.org/10.1016/j.jsbmb.2019.01.017DOI Listing
January 2019
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Divergent Metabolic Effects of Acute Versus Chronic Repeated Forced Swim Stress in the Rat.

Obesity (Silver Spring) 2019 Jan 31. Epub 2019 Jan 31.

Department of Physiology/Endocrine, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Objective: This study sought to examine divergence regarding the impact of acute versus chronic repeated stress on energy balance.

Methods: Rats were exposed to either chronic repeated forced swim (FS) stress for 7 days or an acute stress (a single FS). Body weight and food intake were measured daily. Read More

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http://dx.doi.org/10.1002/oby.22390DOI Listing
January 2019

Clinical management of congenital hypogonadotropic hypogonadism.

Endocr Rev 2019 Jan 29. Epub 2019 Jan 29.

Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Lausanne, Switzerland.

The initiation and maintenance of reproductive capacity in humans is dependent upon pulsatile secretion of the hypothalamic hormone gonadtropin-releasing hormone, GnRH. Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder that results from the failure of the normal episodic GnRH secretion, leading to delayed puberty and infertility. CHH can be associated with an absent sense of smell, also termed Kallmann syndrome, or with other anomalies. Read More

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http://dx.doi.org/10.1210/er.2018-00116DOI Listing
January 2019
21.059 Impact Factor

Home Use of Day and Night Hybrid Closed Loop Insulin Delivery in Very Young Children: A Multicenter 3-Week, Randomized Trial.

Diabetes Care 2019 Jan 28. Epub 2019 Jan 28.

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

Objective: We aimed to assess the feasibility and safety of hybrid closed loop insulin delivery in children with type 1 diabetes aged 1-7 years as well as evaluate the role of diluted insulin on glucose control.

Research Design And Methods: In an open-label, multicenter, multinational, randomized crossover study, 24 children with type 1 diabetes on insulin pump therapy (median age 5 years [interquartile range 3-6] and mean ± SD HbA 7.4 ± 0. Read More

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http://dx.doi.org/10.2337/dc18-1881DOI Listing
January 2019
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Correlates of Insulin-Stimulated glucose Disposal in Recent Onset Type 1 and Type 2 Diabetes.

J Clin Endocrinol Metab 2019 Jan 28. Epub 2019 Jan 28.

Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.

Context And Objective: Not only type 2, but also type 1 diabetes can associate with insulin resistance, as assessed from insulin-stimulated whole body glucose disposal (M-value). We hypothesized that different factors affect the M-value at the onset of type 1 and type 2 diabetes.

Design And Patients: We examined 132 patients with type 1 or type 2 diabetes matched for sex, age, and body mass index with known diabetes duration of less than 12 months. Read More

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http://dx.doi.org/10.1210/jc.2018-02057DOI Listing
January 2019

Clinical Features of Non-obese, Apparently Healthy Japanese Men with Reduced Adipose Tissue Insulin Sensitivity.

J Clin Endocrinol Metab 2019 Jan 23. Epub 2019 Jan 23.

Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Context: Adipose tissue insulin resistance is observed in obese subjects and is considered an early metabolic defect preceding insulin resistance in muscle and liver. While Asians readily develop metabolic disease without obesity, the clinical features of non-obese, apparently healthy Asians with reduced adipose tissue insulin sensitivity (ATIS) have not been elucidated.

Objective: To investigate the clinical parameters associated with reduced ATIS in non-obese, apparently healthy (body mass index <25 kg/m2) Japanese men. Read More

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http://dx.doi.org/10.1210/jc.2018-02190DOI Listing
January 2019
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