7,399 results match your criteria Diabetology & Metabolic Syndrome [Journal]


Alpha-Tocopherol and contrast-induced nephropathy: a meta-analysis of randomized controlled trials.

Int J Vitam Nutr Res 2019 Apr 24:1-9. Epub 2019 Apr 24.

8 Diabetology, Azienda Ospedaliero-Universitaria Careggi and University of Florence, Florence, Italy.

Contrast-induced nephropathy (CIN) is a relevant cause of acute renal dysfunction and is associated with an increased morbidity and mortality. Purpose: Verify the effect of α-tocopherol pre-treatment on CIN prevention in subjects with chronic kidney disease. A Medline/Embase and clinicaltrials. Read More

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https://econtent.hogrefe.com/doi/10.1024/0300-9831/a000573
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http://dx.doi.org/10.1024/0300-9831/a000573DOI Listing
April 2019
1 Read

Patient radiation dose in percutaneous biliary interventions: recommendations for DRLs on the basis of a multicentre study.

Eur Radiol 2019 Apr 23. Epub 2019 Apr 23.

Department for Radiation Protection and Health, Federal Office of Radiation Protection, Salzgitter, Germany.

Objective: Percutaneous biliary interventions (PBIs) can be associated with a high patient radiation dose, which can be reduced when national diagnostic reference levels (DRLs) are kept in mind. The aim of this multicentre study was to investigate patient radiation exposure in different percutaneous biliary interventions, in order to recommend national DRLs.

Methods: A questionnaire asking for the dose area product (DAP) and the fluoroscopy time (FT) in different PBIs with ultrasound- or fluoroscopy-guided bile duct punctures was sent to 200 advanced care hospitals. Read More

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http://link.springer.com/10.1007/s00330-019-06208-6
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http://dx.doi.org/10.1007/s00330-019-06208-6DOI Listing
April 2019
1 Read

SOPH syndrome in three affected individuals showing similarities with progeroid cutis laxa conditions in early infancy.

J Hum Genet 2019 Apr 24. Epub 2019 Apr 24.

Institut für Medizinische Genetik und Humangenetik, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Individuals affected with autosomal recessive cutis laxa type 2B and 3 usually show translucent skin with visible veins and abnormal elastic fibers, intrauterine and/or postnatal growth restriction and a typical triangular facial gestalt. Here we describe three unrelated individuals in whom such a cutis laxa syndrome was suspected, especially after electron microscopy revealed immature and less dense dermal elastic fibers in one of them. However, one of these children also displayed optic atrophy and two hypogammaglobulinemia. Read More

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http://www.nature.com/articles/s10038-019-0602-8
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http://dx.doi.org/10.1038/s10038-019-0602-8DOI Listing
April 2019
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The Role of Muscle Decline in Type 2 Diabetes Development: A 5-Year Prospective Observational Cohort Study.

Nutrients 2019 Apr 12;11(4). Epub 2019 Apr 12.

Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Poland M.C. Skłodowskiej-Curie 24A, 15-276 Bialystok, Poland.

The major risk factors of T2DM (type 2 diabetes mellitus) development are still under investigation. We evaluate the possible risk factors associated with type 2 diabetes (T2DM) in adult subjects during a five-year prospective cohort study. We recruited 1160 subjects who underwent oral glucose tolerance test, anthropometric measurements, and body composition and body fat distribution analysis at a baseline visit and again at follow-up after approximately five years. Read More

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http://dx.doi.org/10.3390/nu11040834DOI Listing

Euthymia in Diabetes: Clinical Evidence and Practice-Based Opinion from an International Expert Group.

Diabetes Ther 2019 Apr 22. Epub 2019 Apr 22.

Department of Diabetology & Internal Medicine, Medical university of Warsaw, Warsaw, Poland.

Aim: To develop an evidence-based expert group opinion on various types of euthymia associated with diabetes mellitus (DM) and its management.

Background: Diabetes mellitus is a metabolic syndrome characterized by diverse biomedical and psychosocial features. Emotional health disturbances may lead to psychological and psychiatric dysfunction and may negatively influence glycemic control. Read More

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http://link.springer.com/10.1007/s13300-019-0614-6
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http://dx.doi.org/10.1007/s13300-019-0614-6DOI Listing
April 2019
1 Read

Cystatin C Is an Important Biomarker for Cardiovascular Autonomic Dysfunction in Chinese Type 2 Diabetic Patients.

J Diabetes Res 2019 18;2019:1706964. Epub 2019 Mar 18.

Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, No. 600 Tianhe Road, Guangzhou, Guangdong 510630, China.

Background: Cardiovascular autonomic dysfunction is closely related to increased mortality in patients with diabetes. Previous studies have proved that cystatin C (CysC) is an important predictor of both peripheral neuropathy and cardiovascular events. However, whether CysC is also associated with cardiovascular autonomic dysfunction remains unclear. Read More

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http://dx.doi.org/10.1155/2019/1706964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442484PMC

High Prevalence of Diabetes in Patients With Primary Aldosteronism (PA) Associated With Subclinical Hypercortisolism and Prediabetes More Prevalent in Bilateral Than Unilateral PA: A Large, Multicenter Cohort Study in Japan.

Diabetes Care 2019 May;42(5):938-945

Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

Objective: To investigate the prevalence and causes of diabetes in patients with primary aldosteronism (PA) in a multi-institutional cohort study in Japan.

Research Design And Methods: The prevalence of diabetes was determined in 2,210 patients with PA (diagnosed or glycated hemoglobin [HbA] ≥6.5% [≥48 mmol/mol]; NGSP) and compared with that of the Japanese general population according to age and sex. Read More

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http://dx.doi.org/10.2337/dc18-1293DOI Listing

The Type 2 Diabetes Susceptibility PROX1 Gene Variants Are Associated with Postprandial Plasma Metabolites Profile in Non-Diabetic Men.

Nutrients 2019 Apr 19;11(4). Epub 2019 Apr 19.

Clinical Research Centre, Medical University of Bialystok, 15-089 Bialystok, Poland.

The prospero homeobox 1 (PROX1) gene may show pleiotropic effects on metabolism. We evaluated postprandial metabolic alterations dependently on the rs340874 genotypes, and 28 non-diabetic men were divided into two groups: high-risk (HR)-genotype (CC-genotype carriers, = 12, 35.3 ± 9. Read More

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http://dx.doi.org/10.3390/nu11040882DOI Listing

Prediction of exocrine and endocrine insufficiency after pancreaticoduodenectomy using volumetry.

Acta Chir Belg 2019 Apr 22:1-22. Epub 2019 Apr 22.

a Department of Hepatobiliary, Endocrine and Transplantation Surgery , Antwerp University Hospital , Belgium.

Objectives: The aim of this study is to evaluate the use of pancreatic volumetric assessment to predict exocrine and endocrine insufficiency after pancreaticoduodenectomy.

Methods: Thirty-seven patients who underwent pancreaticoduodenectomy were included in the study. Endocrine function was assessed in all patients without a history of diabetes using an oral glucose tolerance test. Read More

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April 2019
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Stopping antibiotics after surgical amputation in diabetic foot and ankle infections-A daily practice cohort.

Endocrinol Diabetes Metab 2019 Apr 6;2(2):e00059. Epub 2019 Feb 6.

Service of Infectious Diseases Geneva University Hospitals Geneva Switzerland.

Objective: The appropriate duration of antibiotic therapy for diabetic foot infections (DFI) after surgical amputations in toto is debated. There are discrepancies worldwide.

Methods: Using a clinical pathway for adult DFI patients (retrospective cohort analysis), we conducted a cluster-controlled Cox regression analysis. Read More

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http://dx.doi.org/10.1002/edm2.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458464PMC

Sexual dysfunction is a more common problem in young women with type 1 diabetes than in healthy.

J Sex Marital Ther 2019 Apr 21:1-11. Epub 2019 Apr 21.

a Department of Internal Medicine and Diabetology , Poznan University of Medical Sciences, Raszeja Hospital , Mickiewicza 2 , 60-834 Poznan , Poland.

The aim of the study was to analyze the relationship between the presence of type 1 diabetes and the sexual dysfunction among young women. The study group consisted of 230 women including 70 healthy and 160 with DM1. All the participants voluntarily filled anonymous questionnaire. Read More

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https://www.tandfonline.com/doi/full/10.1080/0092623X.2019.1
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http://dx.doi.org/10.1080/0092623X.2019.1610121DOI Listing
April 2019
1 Read

Clinical outcomes after ABO-incompatible renal transplantation: a systematic review and meta-analysis.

Lancet 2019 Apr 18. Epub 2019 Apr 18.

Clinic of Nephrology and Hypertension, Diabetology and Endocrinology, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany. Electronic address:

Background: ABO-incompatible renal transplantation (ABOi-rTx) is increasingly used to overcome organ shortage. Evidence about its non-inferiority in comparison with ABO-compatible renal transplantation (ABOc-rTx) needs to be analysed at early and late timepoints. We aimed to investigate differences in outcome after ABOi-rTX and ABOc-rTX. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32091-9DOI Listing

Urokinase-type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)-mediated sodium retention in experimental nephrotic syndrome.

Acta Physiol (Oxf) 2019 Apr 21:e13286. Epub 2019 Apr 21.

Department of Internal Medicine, Division of Endocrinology Division of Endocrinology Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Germany.

Aim: In nephrotic syndrome, aberrantly filtered plasminogen (plg) is converted to active plasmin by tubular urokinase-type plasminogen activator (uPA) and thought to lead to sodium retention by proteolytic activation of the epithelial sodium channel (ENaC). This concept predicts that uPA is an important factor for sodium retention and that inhibition of uPA might be protective in nephrotic syndrome.

Methods: Activation of amiloride-sensitive currents by uPA and plg were studied in Xenopus laevis oocytes expressing murine ENaC. Read More

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http://dx.doi.org/10.1111/apha.13286DOI Listing
April 2019
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Copeptin and its role in the diagnosis of diabetes insipidus and the syndrome of inappropriate antidiuresis (SIAD).

Clin Endocrinol (Oxf) 2019 Apr 20. Epub 2019 Apr 20.

Departments of Endocrinology, Diabetology and Metabolism University Hospital Basel, Switzerland.

Copeptin is secreted in an equimolar amount to arginine vasopressin (AVP) but can easily be measured in plasma or serum with a sandwich immunoassay. The main stimuli for copeptin are similar to AVP, i.e. Read More

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http://dx.doi.org/10.1111/cen.13991DOI Listing

Identification of functional lipid metabolism biomarkers of brown adipose tissue aging.

Mol Metab 2019 Apr 4. Epub 2019 Apr 4.

Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany; German Center for Diabetes Research (DZD), München, Neuherberg, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam-Rehbrücke, Nuthetal, Germany. Electronic address:

Objective: Aging is accompanied by loss of brown adipocytes and a decline in their thermogenic potential, which may exacerbate the development of adiposity and other metabolic disorders. Presently, only limited evidence exists describing the molecular alterations leading to impaired brown adipogenesis with aging and the contribution of these processes to changes of systemic energy metabolism.

Methods: Samples of young and aged murine brown and white adipose tissue were used to compare age-related changes of brown adipogenic gene expression and thermogenesis-related lipid mobilization. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22128778183119
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http://dx.doi.org/10.1016/j.molmet.2019.03.011DOI Listing
April 2019
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Expression of Prox1 in Medullary Thyroid Carcinoma Is Associated with Chromogranin A and Calcitonin Expression and with Ki67 Proliferative Index, but Not with Prognosis.

Endocr Pathol 2019 Apr 17. Epub 2019 Apr 17.

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Rue du Bugnon 25, CH-1011, Lausanne, Switzerland.

Medullary thyroid carcinoma (MTC) has been shown to express Prospero homeobox protein 1 (Prox1), a transcription factor whose expression is altered in a variety of human cancers. We conducted a retrospective study on a series of 32 patients with MTC to test the correlation of Prox1 expression in MTC with clinicopathological features and to evaluate its prognostic significance. Correlation of Prox1 immunohistochemical expression with tumor size, proliferative index (Ki67), and calcitonin and CEA serum levels prior to surgery was tested for significant correlations. Read More

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http://link.springer.com/10.1007/s12022-019-9576-5
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http://dx.doi.org/10.1007/s12022-019-9576-5DOI Listing
April 2019
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Anti-HERV-W antibodies are correlated with seroreactivity against Mycobacterium avium subsp. paratuberculosis in children and youths at T1D risk.

Sci Rep 2019 Apr 18;9(1):6282. Epub 2019 Apr 18.

Laboratory of Microbiology, Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

Recent evidence points at the role that human endogenous retroviruses (HERVs) may play through the activation of genes integrated across the human genome. Although a variety of genetic/epigenetic mechanisms maintain most HERVs silenced, independent environmental stimuli including infections may transactivate endogenous elements favoring pathogenic conditions. Several studies associated exposures to Mycobacterium avium subsp. Read More

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http://www.nature.com/articles/s41598-019-42788-5
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http://dx.doi.org/10.1038/s41598-019-42788-5DOI Listing
April 2019
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Time for a reassessment of the treatment of hypothyroidism.

BMC Endocr Disord 2019 Apr 18;19(1):37. Epub 2019 Apr 18.

, 113 Andersons Road, Yandina, QLD 4561, Australia.

Background: In the treatment for hypothyroidism, a historically symptom-orientated approach has given way to reliance on a single biochemical parameter, thyroid stimulating hormone (TSH).

Main Body: The historical developments and motivation leading to that decision and its potential implications are explored from pathophysiological, clinical and statistical viewpoints. An increasing frequency of hypothyroid-like complaints is noted in patients in the wake of this directional shift, together with relaxation of treatment targets. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-019-0365-4DOI Listing
April 2019
1 Read
2.027 Impact Factor

Impact of slow breathing on the blood pressure and subarachnoid space width oscillations in humans.

Sci Rep 2019 Apr 17;9(1):6232. Epub 2019 Apr 17.

Department of Human Physiology, Faculty of Health Sciences, Medical University of Gdansk, Gdansk, Poland.

The aim of the study was to assess cardiac and respiratory blood pressure (BP) and subarachnoid space (SAS) width oscillations during the resting state for slow and fast breathing and breathing against inspiratory resistance. Experiments were performed on a group of 20 healthy volunteers (8 males and 12 females; age 25.3 ± 7. Read More

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http://dx.doi.org/10.1038/s41598-019-42552-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470142PMC

Analysis of Fatty Acid Esters of Hydroxyl Fatty Acid in Selected Plant Food.

Plant Foods Hum Nutr 2019 Apr 16. Epub 2019 Apr 16.

Division of Molecular Medicine Ruđer Bošković Institute, Zagreb, Croatia.

Metabolic syndrome, characterized by obesity, low-grade inflammation, insulin resistance, hyperglycemia, dyslipidemia and hypertension, is a major risk factor for cardiovascular mortality. Preclinical studies on recently discovered classes of lipids - fatty acid esters of hydroxy fatty acids (FAHFA) have revealed their anti-inflammatory and insulin-sensitizing potential. The FAHFA levels are significantly decreased in insulin-resistant individuals, their application exhibited anti-inflammatory effects and restoring the glucose-insulin homeostasis. Read More

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http://link.springer.com/10.1007/s11130-019-00728-8
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http://dx.doi.org/10.1007/s11130-019-00728-8DOI Listing
April 2019
2 Reads

Baseline neutrophil-to-lymphocyte ratio is associated with long-term T2D remission after metabolic surgery.

Acta Diabetol 2019 Apr 16. Epub 2019 Apr 16.

IRCCS Ospedale Policlinico San Martino Genoa - Italian Cardiovascular Network, 10 Largo Benzi, 16132, Genoa, Italy.

Aims: Metabolic surgery is considered as a therapeutic option for obese patients with type 2 diabetes (T2D). In order to identify novel laboratory variables that could improve the selection of patients who might greatly benefit from a surgical approach, we focused on the neutrophil-to-lymphocyte ratio (NLR) as a predictor of long-term T2D remission following metabolic surgery.

Methods: Thirty-one obese patients with T2D included in this pilot study underwent Roux-en-Y gastric bypass or biliopancreatic diversion (BPD) at the Surgical Department of Genoa University, IRCCS Ospedale Policlinico San Martino in Genoa (Italy). Read More

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http://dx.doi.org/10.1007/s00592-019-01345-2DOI Listing

Impact of interprofessional education for medical and nursing students on the nutritional management of in-patients.

GMS J Med Educ 2019 15;36(2):Doc11. Epub 2019 Mar 15.

University Augsburg, Medical Faculty, Department for Medical Education and Educational Research, Augsburg, Germany.

Despite its frequency, malnutrition is underestimated in its importance for morbidity and mortality. Interprofessional nutrition management can improve patient safety and clinical outcomes. An interprofessional education is considered as the basis for good team cooperation. Read More

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http://dx.doi.org/10.3205/zma001219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446465PMC
March 2019
1 Read

Higher dose but not low dose proton pump inhibitors are associated with increased risk of subsequent hip fractures after first hip fracture: A nationwide observational cohort study.

Bone Rep 2019 Jun 1;10:100204. Epub 2019 Apr 1.

Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of the WGKK and AUVA Trauma Center, 1 Medical Department at Hanusch Hospital, Heinrich Collin Str. 30, 1140 Vienna, Austria.

Aim: To examine the association of proton pump inhibitor (PPI) use with subsequent hip fracture incidence in hip fracture patients, accounting for gender, age, PPI doses, PPI initiation before or after first fracture, and year from first fracture in which the first subsequent fracture occurred.

Methods: Data from 31,668 Austrian patients ≥50 years with the first hip fracture between July 2008 and December 2010 were analyzed retrospectively. After exclusion of patients on anti-osteoporotic medication, incidence of subsequent hip fractures was compared between users and non-users of PPIs using regression models. Read More

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http://dx.doi.org/10.1016/j.bonr.2019.100204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451165PMC
June 2019
1 Read

Visit-to-visit fasting plasma glucose variability is an important risk factor for long-term changes in left cardiac structure and function in patients with type 2 diabetes.

Cardiovasc Diabetol 2019 Apr 16;18(1):50. Epub 2019 Apr 16.

Department of Endocrinology & Metabosim, Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, China.

Background: To investigate the effect of visit-to-visit fasting plasma glucose (FPG) variability on the left cardiac structure and function in patients with type 2 diabetes mellitus (T2DM).

Methods: In this prospective cohort study, 455 T2DM patients were included and follow-up for a median of 4.7 years. Read More

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https://cardiab.biomedcentral.com/articles/10.1186/s12933-01
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http://dx.doi.org/10.1186/s12933-019-0854-9DOI Listing
April 2019
1 Read

The Association Between Affective Temperament Traits and Dopamine Genes in Obese Population.

Int J Mol Sci 2019 Apr 15;20(8). Epub 2019 Apr 15.

Chair and Department of Clinical Neuropsychology, Nicolaus Copernicus University in Toruń, Collegium Medicum, Bydgoszcz 85-094, Poland.

Studies indicate the heritable nature of affective temperament, which shows personality traits predisposing to the development of mental disorders. Dopaminergic gene polymorphisms such as , Val158Met, and have been linked to affective disorders in obesity. Due to possible correlation between the aforementioned polymorphisms and the affective temperament, the aim of our research was to investigate this connection in an obese population. Read More

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http://dx.doi.org/10.3390/ijms20081847DOI Listing
April 2019
3 Reads

Comparison of the diagnostic accuracy of the current guidelines for detecting insulinoma.

Eur J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

K Müssig, Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.

Objective: Insulinomas are rare pancreatic endocrine tumors characterized by hypoglycemia. Guidelines by the Endocrine Society (ES), the European (ENETS) and the North American (NANETS) Neuroendocrine Tumor Societies provide divergent diagnostic criteria. This study compared the diagnostic accuracy of these different criteria during the 72-h fasting test. Read More

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https://eje.bioscientifica.com/view/journals/eje/aop/eje-18-
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http://dx.doi.org/10.1530/EJE-18-0879DOI Listing
April 2019
2 Reads

Lipopolysaccharide-binding protein is an early biomarker of cardiac function after radiotherapy for breast cancer.

Int J Radiat Oncol Biol Phys 2019 Apr 13. Epub 2019 Apr 13.

Department of Biostatistics and Translational Medicine, Medical University of Lodz, Poland; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

Purpose: To evaluate the prognostic potential of lipopolysaccharide-binding protein (LBP) levels after breast cancer radiotherapy (RT) for incipient cardiac dysfunction.

Methods And Materials: In this single-centered study, we prospectively enrolled female patients treated for left breast cancer. Healthy age- and sex-matched participants were recruited as controls. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.04.002DOI Listing
April 2019
1 Read

Take a Blood Pressure Pill or Benefit from Renal Denervation?

Eur Heart J 2018 Sep;39(33):3010-3012

Vascular Biology and Hypertension Program, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

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http://dx.doi.org/10.1093/eurheartj/ehy440DOI Listing
September 2018
1 Read

Glucose Responsiveness of β-Cells Depends on Fatty Acids.

Exp Clin Endocrinol Diabetes 2019 Apr 15. Epub 2019 Apr 15.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard-Karls-University of Tuebingen, Tübingen, Germany.

Glucose-stimulated insulin secretion (GSIS) is the gold standard for β-cell function. Both experimental and clinical diabetology, i. e. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0884-2919
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http://dx.doi.org/10.1055/a-0884-2919DOI Listing
April 2019
1 Read

Similar effectiveness of dapagliflozin versus GLP-1 receptor agonists on combined endpoints in routine clinical practice. A multicenter retrospective study.

Diabetes Obes Metab 2019 Apr 15. Epub 2019 Apr 15.

Department of Medicine, University of Padova, Padova, Italy.

Background And Aims: Based on cardiovascular outcome trials, some sodium-glucose contransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) are recommended for secondary cardiovascular prevention in type 2 diabetes (T2D). In this real-world study, we compared the simultaneous reductions in HbA1c, body weight, and systolic blood pressure after initiation of dapagliflozin or GLP-1RA as second or more advanced line of therapy.

Methods: DARWIN-T2D was a retrospective multi-centre study conducted at diabetes specialist clinics in Italy. Read More

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http://dx.doi.org/10.1111/dom.13747DOI Listing

High-dose intravenous versus oral iron in blood donors with iron deficiency: The IronWoMan randomized, controlled clinical trial.

Clin Nutr 2019 Mar 26. Epub 2019 Mar 26.

Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria; Thyroid Endocrinology Osteoporosis Institute Dobnig Graz, Jakob-Redtenbachergasse 10, 8010, Graz, Austria. Electronic address:

Introduction: Frequent blood donation often leads to iron deficiency and even anemia but appropriate strategies for detection and prevention are currently not mandatory. At the Medical University of Graz, we conducted a single-center prospective clinical trial to compare oral and IV iron supplementation in iron deficient blood donors including Austrian regular whole blood and platelet apheresis donors. We aimed to determine the difference of transferrin saturation between the treatment groups 8-12 weeks iron administration besides other parameters of iron status and blood count. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.03.025DOI Listing
March 2019
1 Read

[Diabetes mellitus in childhood and adolescence (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Department für Pädiatrie 1, Medizinische Universität Innsbruck, Anichstraße 35, 6020, Innsbruck, Österreich.

In contrast to adults, type 1 diabetes mellitus (T1D) is the most frequent form of diabetes in childhood and adolescence (>95%). After diagnosis the management of children and adolescents with T1D should take place in highly specialized pediatric units experienced in pediatric diabetology and not in private practices. The lifelong substitution of insulin is the cornerstone of treatment whereby modalities need to be individually adapted for patient age and the family routine. Read More

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http://dx.doi.org/10.1007/s00508-018-1420-2DOI Listing
April 2019
1 Read

ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor.

J Biol Chem 2019 Apr 12. Epub 2019 Apr 12.

Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Argentina.

Type 1 diabetes islet cell autoantigen 512 (ICA512/IA-2) is a tyrosine phosphatase-like intrinsic membrane protein involved in the biogenesis and turnover of insulin secretory granules (SGs) in pancreatic islet β-cells. Whereas its membrane proximal and cytoplasmic domains have been functionally and structurally characterized, the role of ICA512 N-terminal segment named 'regulated endocrine‑specific protein 18 homology domain' (RESP18HD), which encompasses residues 35-131, remains largely unknown. Here we show that ICA512 RESP18HD residues 91-131 encode for an intrinsically disordered region (IDR), which in vitro acts as a condensing factor for the reversible aggregation of insulin and other β-cell proteins in a pH and Znregulated fashion. Read More

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA119.007607
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http://dx.doi.org/10.1074/jbc.RA119.007607DOI Listing
April 2019
8 Reads

Plasma steroid profiles in subclinical compared to overt adrenal Cushing's syndrome.

J Clin Endocrinol Metab 2019 Apr 12. Epub 2019 Apr 12.

Institute of Clinical Chemistry and Laboratory Medicine & University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.

Context: Diagnosis of subclinical adrenal hypercortisolism is based on several tests of the hypothalamic-pituitary-adrenal axis to establish mild alterations of cortisol secretion and dysregulated cortisol physiology.

Objective: This study assessed whether plasma steroid profiles might assist diagnosis of subclinical Cushing's syndrome (SC).

Design: Retrospective cross-sectional study. Read More

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http://dx.doi.org/10.1210/jc.2018-02349DOI Listing
April 2019
2 Reads

Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα.

Nat Commun 2019 04 11;10(1):1684. Epub 2019 Apr 11.

Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, 14157, Sweden.

Obesity triggers the development of non-alcoholic fatty liver disease (NAFLD), which involves alterations of regulatory transcription networks and epigenomes in hepatocytes. Here we demonstrate that G protein pathway suppressor 2 (GPS2), a subunit of the nuclear receptor corepressor (NCOR) and histone deacetylase 3 (HDAC3) complex, has a central role in these alterations and accelerates the progression of NAFLD towards non-alcoholic steatohepatitis (NASH). Hepatocyte-specific Gps2 knockout in mice alleviates the development of diet-induced steatosis and fibrosis and causes activation of lipid catabolic genes. Read More

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http://dx.doi.org/10.1038/s41467-019-09524-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459876PMC
April 2019
1 Read

The impact of dietary protein intake on longevity and metabolic health.

EBioMedicine 2019 Apr 8. Epub 2019 Apr 8.

Department of Diabetology and Endocrinology, Kanazawa Medical University, Japan; Division of Anticipatory Molecular Food Science and Technology, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa, Japan. Electronic address:

Lifespan and metabolic health are influenced by dietary nutrients. Recent studies show that a reduced protein intake or low-protein/high-carbohydrate diet plays a critical role in longevity/metabolic health. Additionally, specific amino acids (AAs), including methionine or branched-chain AAs (BCAAs), are associated with the regulation of lifespan/ageing and metabolism through multiple mechanisms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964193023
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http://dx.doi.org/10.1016/j.ebiom.2019.04.005DOI Listing
April 2019
3 Reads

Pressure ulcer prevalence and prevention rates in Abu Dhabi: an update.

J Wound Care 2019 Apr;28(Sup4):S4-S11

Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.

Objective: This article compares the results from a recent pressure ulcer (PU) prevalence audit at the Sheikh Khalifa Medical City (SKMC) hospital in Abu Dhabi to identify the impact of new prevention initiatives introduced around 2013 and establish the effectiveness of PU prevention strategies, judged quality of nursing care, and costs associated with patients developing a hospital-acquired pressure ulcer (HAPU).

Method: The methods used were based on a previous point prevalence study involving 441 acute care patients, who were assessed using the International Pressure Ulcer Prevalence (IPUP) Survey. Following pre-selection of a 24-hour period for data capture, hospital staff collected PU data. Read More

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http://dx.doi.org/10.12968/jowc.2019.28.Sup4.S4DOI Listing
April 2019
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Effect of basal insulin supplement therapy on diabetic retinopathy in short-duration type 2 diabetes:a one-year randomized parallel-group trial.

J Diabetes 2019 Apr 11. Epub 2019 Apr 11.

Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Background: It is unknown which subsequent treatments benefit diabetic retinopathy (DR). We compared the effects of oral anti-diabetic drugs (OADs) alone and basal insulin-supported OAD therapy (BOT) on DR.

Methods: Two hundred ninety patients, aged 18-65 years, with diabetic durations of 0-5 years, were enrolled between January 2015 and January 2018. Read More

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http://dx.doi.org/10.1111/1753-0407.12928DOI Listing
April 2019
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βklotho is essential for the anti-endothelial mesenchymal transition effects of N-acetyl-seryl-aspartyl-lysyl-proline.

FEBS Open Bio 2019 Apr 10. Epub 2019 Apr 10.

Department of Diabetology & Endocrinology, Kanazawa Medical University, Uchinada, Japan.

Endothelial-mesenchymal transition (EndMT) has emerged as an essential bioprocess responsible for the development of organ fibrosis. We have previously reported that fibroblast growth factor receptor 1 (FGFR1) is involved in the anti-EndMT effect of N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP). FGFR1 is expressed on the cell membrane and performs its biological function through interaction with co-receptors, including βklotho (KLB). Read More

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http://dx.doi.org/10.1002/2211-5463.12638DOI Listing

Sodium-Glucose co-Transporter-2 (SGLT-2) inhibitors and cancer: A Meta-analysis Of Randomized Controlled Trials.

Diabetes Obes Metab 2019 Apr 11. Epub 2019 Apr 11.

Diabetology, Careggi Teaching Hospital and University of Florence, Italy.

Background: Concerns on the effect of SGLT-2 inhibitors (SGLT-2i) have been risen by some studies, showing an increased incidence of bladder cancer, particularly for empagliflozin. Aim of the present meta-analysis of randomized trials is the assessment of the effects of SGLT-2i on overall incidence of malignancies and on different cancer types, synthetizing the results of trials with a duration of at least one year.

Methods: A Medline and Embase search for "Canaglifozin", "Dapaglifozin", "Empaglifozin", "Ertuglifozin", "Ipraglifozin", Tofoglifozin", or "Luseoglifozin" was performed, collecting randomized trials (duration>52 weeks) up to December 1 , 2018, comparing SGLT-2i with placebo or active comparators. Read More

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http://dx.doi.org/10.1111/dom.13745DOI Listing
April 2019
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Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function.

Front Endocrinol (Lausanne) 2019 27;10:187. Epub 2019 Mar 27.

Department of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Japan.

The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health concern, and novel therapeutic strategies to prevent T2DM are urgently needed worldwide. Aging is recognized as one of the risk factors for metabolic impairments, including insulin resistance and T2DM. Inflammation, oxidative stress, and mitochondrial dysfunction are closely related to both aging and metabolic disease. Read More

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http://dx.doi.org/10.3389/fendo.2019.00187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445872PMC
March 2019
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Author Correction: Systematic in vivo evaluation of the time-dependent inflammatory response to steel and Teflon insulin infusion catheters.

Sci Rep 2019 Apr 11;9(1):6183. Epub 2019 Apr 11.

Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. Read More

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http://dx.doi.org/10.1038/s41598-019-40316-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458127PMC

Holistic physical exercise training improves physical literacy among physically inactive adults: a pilot intervention study.

BMC Public Health 2019 Apr 11;19(1):393. Epub 2019 Apr 11.

Cardiovascular Diabetology Research Group Division of Endocrinology and Diabetology Department of Internal Medicine Medical University of Graz, Graz, Austria.

Background: Physical literacy (PL), given as a multidimensional construct, is considered a person's capacity and commitment to a physically active lifestyle. We investigated the effect of a holistic physical exercise training on PL among physically inactive adults.

Methods: A non-randomised controlled study was conducted. Read More

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http://dx.doi.org/10.1186/s12889-019-6719-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458734PMC

Relationship between the dietary glycemic load of the adult Polish population and socio-demographic and lifestyle factors - results of the WOBASZ II study.

Adv Clin Exp Med 2019 Apr 5. Epub 2019 Apr 5.

Department of Epidemiology, Cardiovascular Disease Prevention and Health Promotion, National Institute of Cardiology, Warszawa, Poland.

Background: Cardiovascular disease (CVD) occurs more often among people with a low sociodemographic status, so it is worth knowing if any sociodemographic factor also has an impact on diet quality, defined by glycemic load (GL).

Objectives: Assessment of the relationship between the sociodemographic and lifestyle factors, health status self-assessment and dietary GL of the adult Polish population based on WOBASZ II study results.

Material And Methods: The study included a representative group of the Polish population aged ≥20 years (2,554 men and 3,136 women). Read More

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http://dx.doi.org/10.17219/acem/94151DOI Listing
April 2019
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HDAC4 mutations cause diabetes and induce β-cell FoxO1 nuclear exclusion.

Mol Genet Genomic Med 2019 Apr 9:e602. Epub 2019 Apr 9.

Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty, Max-Delbrueck-Center for Molecular Medicine (MDC), Berlin, Germany.

Background: Studying patients with rare Mendelian diabetes has uncovered molecular mechanisms regulating β-cell pathophysiology. Previous studies have shown that Class IIa histone deacetylases (HDAC4, 5, 7, and 9) modulate mammalian pancreatic endocrine cell function and glucose homeostasis.

Methods: We performed exome sequencing in one adolescent nonautoimmune diabetic patient and detected one de novo predicted disease-causing HDAC4 variant (p. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mgg3.602
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http://dx.doi.org/10.1002/mgg3.602DOI Listing
April 2019
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Effects of plant and animal high protein diets on immune-inflammatory biomarkers: A 6-week intervention trial.

Clin Nutr 2019 Mar 27. Epub 2019 Mar 27.

Senior Scientist Group Nutrition, Immunity and Metabolism, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; University of Potsdam, Institute of Nutritional Science, Potsdam, Germany. Electronic address:

Background & Aims: Pro-inflammatory biomarkers are well-established contributors to insulin resistance and represent valid targets for diabetes management and prevention. Yet, little is known whether nutrition could play a role in modulating various aspects of immune-inflammatory responses. Our aim is to assess the effect of isocaloric animal and plant protein dietary interventions on selected biomarkers representing various immune-inflammatory pathways. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193013
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http://dx.doi.org/10.1016/j.clnu.2019.03.019DOI Listing
March 2019
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4.476 Impact Factor

CFTR and FOXO1 gene expression are reduced and high mobility group box 1 (HMGB1) is increased in the ovaries and serum of women with polycystic ovarian syndrome.

Gynecol Endocrinol 2019 Apr 9:1-5. Epub 2019 Apr 9.

a Division of Pediatric Endocrinology and Diabetology, Department of Obstetrics, Gynecology and Pediatrics , Azienda USL - IRCCS di Reggio Emilia , Reggio Emilia , Italy.

We previously described increased HMGB1 and reduced FOXO1 dependent on CFTR loss of function in cystic fibrosis (CF) and we showed in vitro that HMGB1 was lowered by insulin. Reduced CFTR gene expression has been described in granulosa cells (GC) from PCOS-induced rats. We aimed at studying CFTR and FOXO1 gene expression in GC, HMGB1 concentrations in serum and follicular fluids (FF), and insulin and IL-6 in FF in PCOS women. Read More

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http://dx.doi.org/10.1080/09513590.2019.1599349DOI Listing
April 2019
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Diabetes and heart failure: Is it hyperglycemia or hyperinsulinemia?

Curr Vasc Pharmacol 2019 Apr 8. Epub 2019 Apr 8.

Department of Internal Medicine IV, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, University of Tübingen and Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen. Germany.

The cardiac effects of exogenously administered insulin for the treatment of diabetes (DM) have recently attracted much attention. In particular, it has been questioned whether insulin is the appropriate treatment for patients with type 2 diabetes mellitus (T2DM) and heart failure. While several old and some new studies suggested that insulin treatment has beneficial effects for the heart, recent observational studies indicate associations of insulin treatment with increased risk of developing or worsening of a pre-existing heart failure and higher mortality rates. Read More

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http://dx.doi.org/10.2174/1570161117666190408164326DOI Listing
April 2019
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The effect of vitamin D supplementation on plasma non-oxidised PTH in a randomised clinical trial.

Endocr Connect 2019 Apr 1. Epub 2019 Apr 1.

A Heijboer, Department of Clinical Chemistry, Endocrine Laboratory, Amsterdam Gastroenterology and Metabolism, VU University Medical Center, Amsterdam, Netherlands.

Objective: PTH can be oxidised in vivo, rendering it biologically inactive. Non-oxidised PTH (n-oxPTH) may therefore give a better image of the hormonal status of the patient. While vitamin D supplementation decreases total PTH (tPTH) concentration, the effect on n-oxPTH concentration is unexplored. Read More

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http://dx.doi.org/10.1530/EC-19-0097DOI Listing
April 2019
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Performance of LC-MS/MS and immunoassay based 24-h urine free cortisol in the diagnosis of Cushing's syndrome.

J Steroid Biochem Mol Biol 2019 Apr 5;190:193-197. Epub 2019 Apr 5.

Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig-Maximilians-Universität München, Germany.

24-h urine free cortisol (UFC) is an indicator of integrated cortisol secretion and established screening tool for Cushing's syndrome (CS). Doubts have been raised regarding specificity of immunoassays, and mass spectrometric techniques have been proposed as an alternative. In the present study we compared diagnostic accuracy of UFC measured with LC-MS/MS vs. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2019.04.004DOI Listing
April 2019
1 Read