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    A novel technique: Indocyanine green angiography to prognosticate healing of foot ulcer in critical limb ischemia.
    Ann Vasc Surg 2018 Apr 18. Epub 2018 Apr 18.
    Vascular and Endovascular Surgeon , Divisioin of vascular and endovascular sciences , Medanta-The Medicity Hospital ,India.
    Background: To predict wound healing in patients with critical limb ischemia(CLI) is ongoing issue. Currents methods like ankle-brachial index (ABI), color doppler and transcutaneous oxygen pressure (TCPO), CT angiography are lacking in demonstrating regional perfusion. Indocyanine green angiography (ICGA) has the potential to provide regional perfusion information lacking in other methods. Read More

    The Role of Serum Procalcitonin, Interleukin-6, and Fibrinogen Levels in Differential Diagnosis of Diabetic Foot Ulcer Infection.
    J Diabetes Res 2018 21;2018:7104352. Epub 2018 Feb 21.
    Department of Clinical Microbiology and Infectious Diseases, Dumlupınar University Faculty of Medicine, 43020 Kutahya, Turkey.
    Aims: We aimed to evaluate the roles of interleukin-6 (IL-6), PCT, and fibrinogen levels in the differential diagnosis of the patients with infected diabetic foot ulcer (IDFU) and noninfected diabetic foot ulcer (NIDFU) and to compare those with C-reactive protein (CRP), white blood cell (WBC), and erythrocyte sedimentation rate (ESR).

    Methods: Patients over 18 years with a diagnosis of type 2 diabetes mellitus and DFU who were followed up in our hospital between 1 January 2016 and 1 January 2017 were included in the study. In addition to this patient group, patients with diabetes but without DFU were determined as the control group. Read More

    Decreasing an Offloading Device's Size and Offsetting Its Imposed Limb Length Discrepancy Lead to Improved Comfort and Gait.
    Diabetes Care 2018 Apr 17. Epub 2018 Apr 17.
    Center for Lower Extremity Ambulatory Research (CLEAR), Dr. William M. Scholl College of Podiatric Medicine, Rosalind Franklin University, Chicago, IL.
    Objective: Patient adherence is a challenge in offloading diabetic foot ulcers (DFUs) with removable cast walkers (RCWs). The size and weight of an RCW, changes to gait, and imposed limb length discrepancies may all discourage adherence. This study sought to determine whether RCW size and provision of a contralateral limb lift affected users' comfort and gait. Read More

    Association of Hemoglobin A and Wound Healing in Diabetic Foot Ulcers.
    Diabetes Care 2018 Apr 16. Epub 2018 Apr 16.
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Johns Hopkins University, Baltimore, MD
    Objective: This study evaluated the association between hemoglobin A (A1C) and wound outcomes in patients with diabetic foot ulcers (DFUs).

    Research Design And Methods: We conducted a retrospective analysis of an ongoing prospective, clinic-based study of patients with DFUs treated at an academic institution during a 4.7-year period. Read More

    Expression of vascular endothelial growth factor and matrix metalloproteinase-9 in Lawang propolis extract gel-treated traumatic ulcers in diabetic rats.
    Vet World 2018 Mar 14;11(3):304-309. Epub 2018 Mar 14.
    Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
    Aim: The aim of this study was to determine the effect of propolis extract gel on vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) expression in the traumatic ulcers of rats afflicted with diabetes mellitus (DM).

    Materials And Methods: The study was conducted on 24 male Wistar rats () induced with DM by injecting 50 mg/kg of Streptozotocin, intraperitoneally, and a traumatic ulcer on their lower lip mucosa. These were divided into eight groups: Four each for control and treatment groups. Read More

    Neurotensin-loaded PLGA/CNC composite nanofiber membranes accelerate diabetic wound healing.
    Artif Cells Nanomed Biotechnol 2018 Apr 13:1-9. Epub 2018 Apr 13.
    a Post-doctoral Management Office , Southern Medical University , Guangzhou , China.
    Diabetic foot ulcers (DFUs) are a threat to human health and can lead to amputation and even death. Recently neurotensin (NT), an inflammatory modulator in wound healing, was found to be beneficial for diabetic wound healing. As we demonstrated previously, polylactide-polyglycolide (PLGA) and cellulose nanocrystals (CNCs) (PLGA/CNC) nanofiber membranes show good cytocompatibility and facilitate fibroblast adhesion, spreading and proliferation. Read More

    The Wound Healing Effects of Herbal Cream Containing and Essential Oils in Diabetic Foot Ulcer Model.
    World J Plast Surg 2018 Jan;7(1):45-50
    Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran.
    Background: The number of diabetic patients in adult population is increasing. All this population are at risk of developing diabetic foot ulcers (DFUs) that are associated with unwanted ailments and high mortality. In spite of current therapies for DFUs, further therapies are needed to help the patients. Read More

    Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model.
    Exp Mol Med 2018 Apr 13;50(4):29. Epub 2018 Apr 13.
    Department of Interventional & Vascular Surgery, Tenth People's Hospital of Tongji University, No. 301 Middle Yan Chang Road, Shanghai, 200072, China.
    Diabetic foot ulcers (DFU) increase the risks of infection and amputation in patients with diabetes mellitus (DM). The impaired function and senescence of endothelial progenitor cells (EPCs) and high glucose-induced ROS likely exacerbate DFUs. We assessed EPCs in 60 patients with DM in a hospital or primary care setting. Read More

    Outpatient Negative-Pressure Wound Therapy Following Surgical Debridement: Results and Complications.
    Adv Skin Wound Care 2018 Apr 11. Epub 2018 Apr 11.
    Eran Tamir, MD, is Senior Foot & Ankle Surgeon, Department of Orthopedics, Assaf HaRofeh Medical Center, Zerifin, Israel. Aharon S. Finestone, MD, is Orthopedic Surgeon, Assaf HaRofeh Medical Center, Zerifin, Israel. Itay Wiser, MD, is Lecturer, Department of Epidemiology, Sackler School of Medicine, Tel Aviv University, Israel. Yoram Anekstein, MD, is Head of the Spine Unit, Orthopedic Surgery Department, Assaf HaRofeh Medical Center, Zerifin, Israel. Gabriel Agar, MD, is Head of the Orthopedic Department, Assaf HaRofeh Medical Center, Zerifin, Israel.
    Objective: To present results and complications in a case series of outpatients with diabetic and neuropathic foot ulcers with exposed bone following surgical debridement treated with negative-pressure wound therapy (NPWT).

    Methods: Retrospective data were obtained from digital medical records from the Maccabi Health Services High Risk Foot Clinic in Tel Aviv, Israel, between 2009 and 2014. Medical records examined were those of clinic outpatients with exposed bone following partial foot amputation or selective bone debridement (University of Texas grade III-A) treated with NPWT. Read More

    Publicly Reported Wound Healing Rates: The Fantasy and the Reality.
    Adv Wound Care (New Rochelle) 2018 Mar;7(3):77-94
    Strategic Solutions, Inc., Cody, Wyoming.
    We compare real-world data from the U.S. Wound Registry (USWR) with randomized controlled trials and publicly reported wound outcomes and develop criteria for honest reporting of wound outcomes, a requirement of the new Quality Payment Program (QPP). Read More

    Glycaemic indices and haemoglobin A1c as predictors for non-healing ulcers.
    J Wound Care 2018 Apr;27(Sup4):S6-S11
    Associate Professor, University of Miami Miler School of Medicine, Clinical Research Center, Miami, FL.
    Objective: Non-healing lower extremity ulcers (NHLU) are a common podiatric complication of diabetes, with poor glycaemic control as a risk factor for development. Glycaemic indices, such as haemoglobin A1c (HbA1c) and fasting plasma glucose (FPG), are used to diagnose and to monitor diabetes. Using a population-based, nationally representative sample, we evaluate the relationship between glycaemic indices and NHLU (as defined by the patient) to propose glycaemic thresholds for clinical suspicion of patient NHLU status. Read More

    An evaluation of an ultrasonic debridement system in patients with diabetic foot ulcers: a case series.
    J Wound Care 2018 Apr;27(4):222-228
    Professor, Department of Medical, Surgical, Neurologic, Metabolic and Aging Sciences, University of Campania, 'Luigi Vanvitelli', Piazza Miraglia 2, Napoli, Campania, Italy.
    Objective: This study evaluated the use of ultrasonic debridement in patients with diabetic foot ulcers (DFU).

    Method: In this prospective, single-arm, open-label study, all patients with DFUs underwent wound debridement by ultrasonic debridement system (SonicOne OR Ultrasonic debridement system). Wherever possible, the edges were approximated by means of stitches. Read More

    Health Sensors, Smart Home Devices, and the Internet of Medical Things: An Opportunity for Dramatic Improvement in Care for the Lower Extremity Complications of Diabetes.
    J Diabetes Sci Technol 2018 Apr 1:1932296818768618. Epub 2018 Apr 1.
    3 Southwestern Academic Limb Salvage Alliance (SALSA), Department of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
    Objective: The prevalent and long-neglected diabetic foot ulcer (DFU) and its related complications rank among the most debilitating and costly sequelae of diabetes. With the rise of the Internet of medical things (IoMT), along with smart devices, the med-tech industry is on the cusp of a home-care revolution, which could also create opportunity for developing effective solutions with significant potential to reduce DFU-associated costs and saving limbs. This article discusses potential applications of IoMT to the DFU patient population and beyond. Read More

    Use of Dehydrated Human Amnion/Chorion Membrane Allografts in More Than 100 Patients with Six Major Types of Refractory Nonhealing Wounds.
    J Am Podiatr Med Assoc 2018 Mar;108(2):84-89
    Background: Biochemical properties of the amniotic membrane help modulate inflammation and enhance soft-tissue healing. In controlled trials, the efficacy of dehydrated human amnion/chorion membrane (dHACM) allografts has been established. Our purpose is to describe our experience with using dHACM to treat nonhealing wounds of various etiologies. Read More

    A Diabetic Elderly Man with Finger Ulcer.
    Korean J Fam Med 2018 Mar 22;39(2):126-129. Epub 2018 Mar 22.
    Dermatology Department, Hospital Raja Perempuan Zainab 2, Kelantan, Malaysia.
    Fixed cutaneous sporotrichosis is a differential diagnosis that can be considered in diabetic patients who present with a poorly healing ulcer. Although its prevalence is low, it can occur in patients with immunocompromised status. Here we report a case of a 70-year-old man with diabetes mellitus who presented with a 1-month history of an unhealed ulcer over the tip of his left middle finger. Read More

    The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification independently predicts wound healing in diabetic foot ulcers.
    J Vasc Surg 2018 Apr 2. Epub 2018 Apr 2.
    Diabetic Foot and Wound Service, The Johns Hopkins Hospital, Baltimore, Md; Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Md. Electronic address:
    Objective: Previous studies have reported correlation between the Wound, Ischemia, and foot Infection (WIfI) classification system and wound healing time on unadjusted analyses. However, in the only multivariable analysis to date, WIfI stage was not predictive of wound healing. Our aim was to examine the association between WIfI classification and wound healing after risk adjustment in patients with diabetic foot ulcers (DFUs) treated in a multidisciplinary setting. Read More

    Acetic acid dressings: Finding the Holy Grail for infected wound management.
    Indian J Plast Surg 2017 Sep-Dec;50(3):273-280
    Department of Microbiology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.
    Background: Wounds have since long, contributed majorly to the health-care burden. Infected long-standing non-healing wounds place many demands on the treating surgeon and are devastating for the patients physically, nutritionally, vocationally, financially, psychologically and socially. Acetic acid has long been included among agents used in the treatment of infected wounds. Read More

    Multicenter, randomized controlled, observer-blinded study of a nitric oxide generating treatment in foot ulcers of patients with diabetes - ProNOx1 study.
    Wound Repair Regen 2018 Apr 4. Epub 2018 Apr 4.
    Strategic Solutions, Inc., 1143 Salsbury Avenue, Cody, USA, WY 82414.
    The aim of this multi-center, prospective, observer-blinded, parallel group, randomized controlled trial was to assess the safety and efficacy of EDX110, a nitric oxide generating medical device, in the treatment of diabetic foot ulcers in a patient group reflecting "real world" clinical practice compared against optimal standard care. Participants were recruited from ten hospital sites in multidisciplinary foot ulcer clinics. The ulcers were full thickness, with an area of 25-2500mm and either a palpable pedal pulse or ankle brachial pressure index >0. Read More

    Assessment of telomerase activity in leukocytes of type 2 diabetes mellitus patients having or not foot ulcer: Possible correlation with other clinical parameters.
    Exp Ther Med 2018 Apr 25;15(4):3420-3424. Epub 2018 Jan 25.
    Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece.
    Telomerase is the enzyme that maintains telomere length by adding telomeric repeats after each cell division. Numerous metabolic factors such as obesity, insulin resistance or physical inactivity have been associated with shortened telomeres. In the present study, we assessed telomerase activity in diabetic patients having or not foot ulcer. Read More

    Relationship between plasma angiogenic growth factors and diabetic foot ulcers.
    Clin Chim Acta 2018 Mar 31;482:95-100. Epub 2018 Mar 31.
    Department of Endocrinology, The Second Affiliated Hospital of Hainan Medical University, HaiKou 570311, Hainan Province, China. Electronic address:
    Background: Angiogenic growth factors play an important role in wound healing. However, their associations with diabetic foot ulcers (DFUs) in humans have rarely been investigated. We examined the relationships between circulating concentrations of vascular endothelial growth factor (VEGF)-A and placenta growth factor (PlGF), and DFU risk. Read More

    Managing the Diabetic Foot Ulcer: How Best Practices Fit the Real 2018 United States.
    Surg Technol Int 2018 Mar 29;31. Epub 2018 Mar 29.
    Vice Chairman of General Surgery, Director of Surgical Clinical Research, Mount Sinai St. Luke's - West Hospitals, New York, New York.
    Diabetes Mellitus is a serious systemic illness that has an epidemic-like increasing prevalence in the United States, as well as the rest of the world. With the increasing number of people with diabetes comes the higher incidence of diabetes-related complications. One of these known complications, diabetic foot ulcers (DFU), has an estimated lifetime incidence of 15% in diabetics. Read More

    Stereological and molecular studies on the combined effects of photobiomodulation and human bone marrow mesenchymal stem cell conditioned medium on wound healing in diabetic rats.
    J Photochem Photobiol B 2018 Mar 26;182:42-51. Epub 2018 Mar 26.
    Noveratech LLC of Louisville, KY, Price Institute of Surgical Research, Department of Surgery, University of Louisville, Louisville, KY, USA. Electronic address:
    We investigated the effects of conditioned medium (CM) from human bone marrow mesenchymal stem cells (h BMMSC)s and pulse wave photobiomodulation (PW PBM), applied alone or in combination, on the stereological parameters and gene expression of some growth factors, during wound healing in a streptozotocin (STZ)-induced rat model of type one diabetes mellitus (T1DM). T1DM was induced in 72 rats and two incisions were made in each animal. The rats were assigned to one of four groups: a control (placebo) group, a Laser group (890 nm, 80 Hz, 0. Read More

    Prevalence and related risk factors of diabetic foot ulcer in Ahvaz, south west of Iran.
    Diabetes Metab Syndr 2018 Mar 22. Epub 2018 Mar 22.
    Department of Epidemiology and Biostatistics, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
    Aims: The aim of this study was to evaluate the prevalence of diabetic foot ulcer and its related risk factors.

    Materials And Methods: In this descriptive cross-sectional study, 605 patients with diabetes were evaluated in July 2014. A checklist was used to obtain demographic data, diabetes related data, past medical history, and physical examination data. Read More

    Collagen Powder in Wound Healing.
    J Drugs Dermatol 2018 Apr;17(4):403-408
    Chronic wounds, such as pressure ulcers, diabetic foot ulcers, and venous leg ulcers, are associated with high costs, poor quality of life, and significant morbidity and mortality. A chronic wound develops when progression through the normal phases of wound healing goes awry, creating a hostile environment with elevated levels of pro-inflammatory cytokines, increased matrix metalloproteinases (MMPs), destruction of extracellular matrix (ECM) components, and diminished activity of growth factors and other soluble mediators. The advent of advanced wound care therapies allows for a targeted approach to the treatment of nonhealing wounds by addressing specific molecular defects in healing. Read More

    [Clinical efficacy analysis of transverse tibial bone transport combined with vacuum drainage for the treatment of diabetic foot ulcer].
    Zhongguo Gu Shang 2018 Mar;31(3):232-236
    Department of Orthpaedic, Shanxi Provincial People's Hospital, Taiyuan 030012, Shanxi, China;
    Objective: To investigate clinical effect of transverse tibial bone transport micro vessels regeneration technology combined with vacuum drainage in treating diabetic foot ulcer.

    Methods: From November 2015 and December 2016, clinical data of 19 diabetic foot ulcer patients treated with transverse tibial bone transport micro vessels regeneration technology combined with vacuum drainage were retrospective analyzed, including 15 males and 4 females aged from 42 to 82 years old with an average of (64.57±7. Read More

    A Perioperative Approach to Increase Limb Salvage When Treating Foot Ulcers in Patients With Diabetes.
    AORN J 2018 Apr;107(4):431-440
    Foot ulceration in patients with diabetes increases the risk of lower extremity amputation. Major amputations produce substantial adverse consequences, increase length of hospital stay, diminish quality of life, and increase mortality. In this article, we describe approaches that decrease amputations and improve the quality of life for patients with diabetes and foot ulcers. Read More

    Penile calciphylaxis in a patient on combined peritoneal dialysis and hemodialysis.
    CEN Case Rep 2018 Mar 28. Epub 2018 Mar 28.
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
    Calciphylaxis presents with painful purpura and intractable skin ulcers on the trunk and particularly the distal extremities, and it mainly occurs in patients on chronic dialysis. A 66-year-old man with renal failure due to diabetic nephropathy was on peritoneal dialysis alone for 1 year, followed by peritoneal dialysis combined with hemodialysis for 3 years. He developed calciphylaxis of the penis, which was diagnosed from the skin biopsy findings and clinical observation. Read More

    The perifascial areolar tissue and negative pressure wound therapy for one-stage skin grafting on exposed bone and tendon.
    J Med Invest 2018 ;65(1.2):96-102
    Department of Plastic and Reconstructive Surgery, Tokushima University Graduate School of Medical Science.
    Background: Factors such as exposed bones or tendons can inhibit wound healing and make it a lengthy process unless aggressive debridement or vascularized flap surgery are performed. We have developed a new procedure involving simultaneous application of a skin graft and perifascial areolar tissue (PAT) and negative pressure wound therapy.

    Methods: Of 8 patients with wounds, bones, tendons, and thick fascia were exposed in 4, 2, and 2 cases, respectively. Read More

    Immuno-modulatory effect of local rhEGF treatment during tissue repair in diabetic ulcers.
    Endocr Connect 2018 Apr 28;7(4):584-594. Epub 2018 Mar 28.
    Department of Medicine and Medical SpecialitiesFaculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain.
    Wound healing is a complex process that can be severely impaired due to pathological situations such as diabetes mellitus. Diabetic foot ulcers are a common complication of this pathology and are characterized by an excessive inflammatory response. In this work, the effects of local treatment with recombinant human epidermal growth factor (rhEGF) were studied using a full-thickness wound healing model in streptozotocin-induced diabetic rats. Read More

    Utilization of a Viable Human Amnion Membrane Allograft in Elderly Patients With Chronic Lower Extremity Wounds of Various Etiologies.
    Wounds 2018 Mar;30(3):E36-E40
    Medical Director, Wound Care Institute of Ocean County, Toms River, NJ; and Partner, Ocean County Foot and Ankle Surgical Associates, Toms River, NJ.
    ntroduction. Chronic nonhealing wounds are a growing health care problem in the United States, afflicting more than 6.5 million patients annually. Read More

    Effect of a New Purified Collagen Matrix With Polyhexamethylene Biguanide on Recalcitrant Wounds of Various Etiologies: A Case Series.
    Wounds 2018 Mar;30(3):72-78
    Wayne UNC Health Care's Wound Healing and Hyperbaric Center, Goldsboro, NC.
    Introduction: The management of chronic, nonhealing wounds in patients with multiple comorbidities continues to be a challenge for health care practitioners. Chronic wounds typically do not progress through the normal phases of wound healing and generally remain stagnant during the inflammatory phase, resulting in an increase in proteolytic enzymes with degradation of the extracellular matrix. Bacterial biofilm has been documented to be one of the main factors delaying wound healing, resulting in the prolongation of the inflammatory phase. Read More

    Application of Viable Cryopreserved Human Placental Membrane Grafts in the Treatment of Wounds of Diverse Etiologies: A Case Series.
    Wounds 2018 Mar;30(3):57-61
    Temple University School of Podiatric Medicine, Philadelphia, PA.
    There is evidence in the literature that viable cryopreserved human placental membrane (vCHPM) grafts are effective in treating diabetic foot ulcers and venous leg ulcers.

    Objective: This case series presents 3 cases of chronic ulcerations - 1 arterial ulcer (AU), 1 pressure ulcer (PU), and 1 recurrence of a pyoderma gangrenosum ulcer (PGU) - that had failed previous courses of standard wound care and were subsequently treated with vCHPM to determine if the treatment is an effective modality for treating wounds of these etiologies.

    Materials And Methods: This retrospective review describes 3 cases in which patients with chronic wounds that had failed standard of care treatments for more than 4 weeks were subsequently treated with weekly applications of vCHPM. Read More

    Anxiety and Depression Among Adult Patients With Diabetic Foot: Prevalence and Associated Factors.
    J Clin Med Res 2018 May 16;10(5):411-418. Epub 2018 Mar 16.
    The National Center (Institute) for Diabetes, Endocrinology and Genetic, Amman, Jordan.
    Background: Diabetic foot is a frequent complication of diabetes mellitus with subsequent disturbances in the daily life of the patients. The co-existence of depression and anxiety among diabetic foot patients is a common phenomenon and the role of each of them in perpetuating the other is highlighted in the literature. Our study aimed to determine the prevalence rates of anxiety and depression, and to examine the associated risk factors among diabetic foot patients. Read More

    Molecular and culture based assessment of bacterial pathogens in subjects with diabetic foot ulcer.
    Diabetes Metab Syndr 2018 Mar 16. Epub 2018 Mar 16.
    Rajiv Gandhi Centre for Diabetes and Endocrinology, J.N Medical College, Aligarh Muslim University, Aligarh, U.P, 202002, India. Electronic address:
    Introduction: Expeditious and precise discerning of bacterial pathogens is a fundamental grail, of clinical diagnostic microbiology. Genotypic detection is a budding substitute to recognize phenotypic culture based processes in bacterial identification.

    Aims: We report a comparative evaluation of biochemical and genomic-based assays for exploring the commonest bacterial flora of infected diabetic foot ulcers along with clinical variables of subjects enrolled. Read More

    The effect of combined pulsed wave low-level laser therapy and mesenchymal stem cell-conditioned medium on the healing of an infected wound with methicillin-resistant Staphylococcal aureus in diabetic rats.
    J Cell Biochem 2018 Mar 25. Epub 2018 Mar 25.
    Cellular and Molecular Biology Research Center, and Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    This study aims to investigate the combined effects of Pulsed wave low-level laser therapy (PW LLLT) and human bone marrow mesenchymal stem cell-conditioned medium (hBM-MSC-CM) on the microbial flora and tensiometrical properties of an infected wound model with methicillin-resistant staphylococcal aureus (MRSA) in an experimental model for Type 1 diabetes mellitus (TIDM). TIDM was induced in rats by streptozotocin (STZ). One full-thickness excision was made on the backs of the rats. Read More

    The Hyperbaric Oxygen Therapy Registry: Driving quality and demonstrating compliance.
    Undersea Hyperb Med 2018 Jan-Feb;45(1):1-8
    TeamHealth Strategic Solutions Inc., Cody, Wyoming U.S.
    Objective: To provide an update on the status of provider participation in the US Wound Registry (USWR) and its specialty registry the Hyperbaric Oxygen Therapy Registry (HBOTR), which provide much-needed national benchmarking and quality measurement services for hyperbaric medicine.

    Methods: Providers can meet many requirements of the Merit-Based Incentive Payment System (MIPS) and simultaneously participate in the HBOTR by transmitting Continuity of Care Documents (CCDs) directly from their certified electronic health record (EHR) or by reporting hyperbaric quality measures, the specifications for which are available free of charge for download from the registry website as electronic clinical quality measures for installation into any certified EHR. Computerized systems parse the structured data transmitted to the USWR. Read More

    Monitoring of pH and temperature of neuropathic diabetic and non-diabetic foot ulcers for 12-weeks: an observational study.
    Wound Repair Regen 2018 Mar 22. Epub 2018 Mar 22.
    Alliance for Research and Innovation in Wounds.
    Wound bed assessment is largely reliant on subjective interpretation without recourse to objective tools or biomarkers. The identification of a point of care, reliable biomarker would enhance assessment and ultimately clinical decision-making. Two potentially emerging wound biomarkers exist: surface pH and surface temperature. Read More

    Clinical Prospective Study on the Use of Subcutaneous Carboxytherapy in the Treatment of Diabetic Foot Ulcer.
    Surg Technol Int 2018 Mar 22;31. Epub 2018 Mar 22.
    Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
    Diabetic footfoot ulcer (DFU) is a serious complication of diabetes mellitus, and possibly the major morbidity of the diabetic foot. It is the most common foot injury in diabetic patients and can lead to lower-extremity amputation. Management of DFU requires a systematic knowledge of the major risk factors for amputation, frequent routine evaluation, scrupulous preventive maintenance, and correction of peripheral arterial insufficiency. Read More

    Fifty-Patient Study Evaluating the Efficacy of Modified Collagen With Glycerin in Periwound Skin Management.
    Int J Low Extrem Wounds 2018 Mar 22;17(1):54-61. Epub 2018 Mar 22.
    1 Kuala Lumpur Hospital, Selangor, Malaysia.
    The management of chronic nonhealing ulcers pose a great challenge because they are associated with morbidity and increased costs. This report presents the observations of standard management along with application of modified collagen with glycerin (MCG) in the periwound area for management of nonhealing wounds. This observational report included 50 patients (33 male, 17 female) aged 24 to 94 years having nonhealing wounds. Read More

    Prevalence, Clinical Presentation, and Factors Associated With Diabetic Foot Ulcer in Two Regional Hospitals in Cameroon.
    Int J Low Extrem Wounds 2018 Mar 22;17(1):42-47. Epub 2018 Mar 22.
    1 Health and Human Development (2HD) Research Network, Douala, Cameroon.
    This study aimed to determine the prevalence of diabetic foot ulcer and high risk for ulceration, describe the clinical presentation, and identify factors associated with diabetic foot ulcer in the Southwest regional hospitals of Cameroon. In this cross-sectional study, data were collected using a structured questionnaire administered to consecutive patients with diabetes. Findings from detailed foot examination were recorded. Read More

    Virulence Factor Genes in Staphylococcus aureus Isolated From Diabetic Foot Soft Tissue and Bone Infections.
    Int J Low Extrem Wounds 2018 Mar 22;17(1):36-41. Epub 2018 Mar 22.
    5 University of Washington, Seattle, WA, USA.
    The aim of this study is to describe the presence of genes encoding for 4 virulence factors (pvl, eta, etb, and tsst), as well as the mecA gene conferring resistance to beta-lactam antibiotics, in patients with diabetes and a staphylococcal foot infection. We have also analyzed whether isolates of Staphylococcus aureus from bone infections have a different profile for these genes compared with those from exclusively soft tissue infections. In this cross-sectional study of a prospectively recruited series of patients admitted to the Diabetic Foot Unit, San Juan de Dios Hospital, San José, Costa Rica with a moderate or severe diabetic foot infection (DFI), we collected samples from infected soft tissue and from bone during debridement. Read More

    The Proteolytic Fraction from Latex of Vasconcellea cundinamarcensis (P1G10) Enhances Wound Healing of Diabetic Foot Ulcers: A Double-Blind Randomized Pilot Study.
    Adv Ther 2018 Apr 21;35(4):494-502. Epub 2018 Mar 21.
    Departamentos de Farmacologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
    Introduction: The aim of the study was to investigate the role of the proteolytic fraction from Vasconcellea cundinamarcensis, designated as P1G10, on the healing of chronic foot ulcers in neuropathic patients with diabetes 2.

    Methods: Fifty patients were enrolled in a prospective, randomized, double-blind trial, to verify the efficacy and safety of a topical dressing formulated with 0.1% P1G10, intended for wound healing, versus a hydrogel (control) protocol. Read More

    Decreased health-related quality of life in patients with diabetic foot problems.
    Diabetes Metab Syndr Obes 2018 7;11:35-43. Epub 2018 Mar 7.
    Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok Noi, Bangkok, Thailand.
    Purpose: The aim of this study was to investigate health-related quality of life (HRQoL) in patients with diabetic foot problems and compare the HRQoL between diabetic patients with: 1) diabetic foot problems (DF), including diabetic foot ulcer (DFU) or amputation (AMPU); 2) other diabetic complications (COM), such as diabetic retinopathy (DR), end-stage renal disease (ESRD), or coronary artery disease (CAD); and 3) no diabetic complication (CON).

    Patients And Methods: A total of 254 diabetic patients were studied in a cross-sectional setting. HRQoL was evaluated using Thai version of the Euro Quality of Life Questionnaire (EuroQoL), with five dimensions and five-level scale (EQ-5D-5L). Read More

    Local warming therapy for treating chronic wounds: A systematic review.
    Medicine (Baltimore) 2018 Mar;97(12):e9931
    Department of Anesthesia.
    Background: Several studies suggest that local warming therapy (LWT) may help to treat chronic wounds, such as pressure ulcers, venous ulcers, arterial ulcers, and diabetic foot ulcers. However, evidence supporting the efficacy of this treatment is still incomplete. This study aimed to assess the effects of LWT in treating chronic wounds. Read More

    Current Challenges and Opportunities in the Prevention and Management of Diabetic Foot Ulcers.
    Diabetes Care 2018 Apr;41(4):645-652
    Division of Diabetes, Endocrinology and Gastroenterology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, U.K., and Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL.
    Diabetic foot ulcers remain a major health care problem. They are common, result in considerable suffering, frequently recur, and are associated with high mortality, as well as considerable health care costs. While national and international guidance exists, the evidence base for much of routine clinical care is thin. Read More

    Preparation and standardization of Mathan Tailam: A classical Siddha formulation for diabetic ulcerative wound healing.
    J Ayurveda Integr Med 2018 Mar 16. Epub 2018 Mar 16.
    Captain Srinivasa Murti Regional Ayurveda Drug Development Institute, Central Council for Research in Ayurvedic Sciences, AA Hospital Campus, Arumbakkam, Chennai 600106, India.
    Background: Increasing popularity of Mathan Tailam (mattan tailam, pachai ennai) for the treatment of diabetic foot ulcer necessitated standardization and quality control of this medicated oil both in large scale production and quality check in marketed drug.

    Objective: Present study aims to develop standard operating procedure for the preparation of Mathan Tailam as per Siddha Formulary of India and its standardization using suitable analytical techniques.

    Materials And Methods: Mathan Tailam was prepared as per Siddha Formulary of India. Read More

    Does the Start of Dialysis Initiate a Period of Increased Risk of Ulceration or Amputation?
    J Am Podiatr Med Assoc 2018 Jan;108(1):1-5
    Background: Dialysis therapy is associated with an increased incidence of lower-extremity wounds and amputations. We compared the incidence of foot ulcers and amputations before and after the start of dialysis.

    Methods: We evaluated 150 consecutive diabetic patients receiving dialysis and compared the incidence of foot complications 30 months before and after initiation of hemodialysis. Read More

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