7,705 results match your criteria Diabetic Ulcers


Intramedullary nail versus external fixator for ankle arthrodesis in Charcot neuroarthropathy: A meta-analysis of comparative studies.

J Orthop Surg (Hong Kong) 2019 May-Aug;27(2):2309499019836012

1 Department of Orthopedics, Lebanese American University Medical Center-Rizk Hospital, Achrafieh, Beirut, Lebanon.

Purpose:: Ankle Charcot neuroarthropathy presents a great challenge for treatment. While conservative treatments yield poor results, arthrodesis is considered the treatment of choice for unstable Charcot ankles. There are two methods used for ankle fusion: retrograde intramedullary nail (IMN) and external fixator (EF). Read More

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http://dx.doi.org/10.1177/2309499019836012DOI Listing
March 2019
2 Reads

Burden of diabetic foot ulcer in Nigeria: Current evidence from the multicenter evaluation of diabetic foot ulcer in Nigeria.

World J Diabetes 2019 Mar;10(3):200-211

Department of Medicine, Federal Medical Center Umuahia, Abia 440001, Nigeria.

Background: Nigeria bears the greatest burden of diabetes prevalence in Sub-Saharan Africa. Diabetic foot ulcer (DFU) is a serious and potentially life-threatening complication of diabetes. Significant improvements in diabetic foot incidence and outcomes have been recorded in many Western countries in the past decade. Read More

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http://dx.doi.org/10.4239/wjd.v10.i3.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422858PMC
March 2019
3 Reads

Role of the PI3K/AKT (mTOR and GSK3β) signalling pathway and photobiomodulation in diabetic wound healing.

Cytokine Growth Factor Rev 2019 Mar 12. Epub 2019 Mar 12.

Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, 2028, South Africa. Electronic address:

Activated phosphatidylinositol 3 kinase/Protein kinase B (PI3K/AKT) signalling with increased or reduced mTOR and GSK3β activity influences the wound repair process. Diabetic wounds, usually ulcerated, are characterised by reduced growth factors and cellular performance. The occurrence of diabetic ulcers is linked to peripheral arterial disease, neuropathy, and wound contamination. Read More

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http://dx.doi.org/10.1016/j.cytogfr.2019.03.001DOI Listing
March 2019
2 Reads

Prevalence and Determinants of Diabetic Foot Ulcers and Lower Extremity Amputations in Three Selected Tertiary Hospitals in Ghana.

J Diabetes Res 2019 11;2019:7132861. Epub 2019 Feb 11.

Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Background: The occurrence and complications of diabetes are increasing worldwide. This study examined the prevalence and determinants of diabetic foot ulcers and lower extremity amputations in three selected tertiary hospitals in Ghana.

Methods: A cross-sectional multicenter study involving 100 subjects was carried out. Read More

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http://dx.doi.org/10.1155/2019/7132861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388336PMC
February 2019
1 Read

Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes.

Proc Natl Acad Sci U S A 2019 Mar 18. Epub 2019 Mar 18.

Department of Molecular Medicine and Surgery, Karolinska Institutet, 17176 Stockholm, Sweden;

Diabetic foot ulcerations (DFUs) represent a major medical, social, and economic problem. Therapeutic options are restricted due to a poor understanding of the pathogenic mechanisms. The Notch pathway plays a pivotal role in cell differentiation, proliferation, and angiogenesis, processes that are profoundly disturbed in diabetic wounds. Read More

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http://dx.doi.org/10.1073/pnas.1900351116DOI Listing

Tibial nerve decompression for the prevention of the diabetic foot: a cost-utility analysis using Markov model simulations.

BMJ Open 2019 Mar 15;9(3):e024816. Epub 2019 Mar 15.

Johns Hopkins University Carey Business School, Baltimore, Maryland, USA.

Objective: To determine whether tibial neurolysis performed as a surgical intervention for patients with diabetic neuropathy and superimposed tibial nerve compression in the prevention of the diabetic foot is cost-effective when compared with the current prevention programme.

Design: A baseline analysis was built on a 5-year model to determine the cumulative incidence of foot ulcers and amputations with each strategy. Subsequently, a cost-effectiveness analysis and cohort-level Markov simulations were conducted with a model composed of 20 6-month cycles. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024816DOI Listing
March 2019
1 Read

Adjuvant antibiotic loaded bio composite in the management of diabetic foot osteomyelitis - A multicentre study.

Foot (Edinb) 2019 Jan 11;39:22-27. Epub 2019 Jan 11.

Trauma and Orthopaedics Department, Wythenshawe Hospital, Manchester University Foundation Trust, United Kingdom. Electronic address:

Background: Diabetic foot ulcers are associated with a high morbidity and are common cause of non-traumatic lower limb amputations. The effect of debridement and the use of an adjuvant local antibiotic carrier in the treatment of diabetic foot ulcers with osteomyelitis was evaluated.

Methods: A retrospective review of patients with diabetic foot ulceration and osteomyelitis treated by debridement with adjuvant local antibiotic was performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09582592183016
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http://dx.doi.org/10.1016/j.foot.2019.01.005DOI Listing
January 2019
7 Reads

[Internal diagnostic validation of patients with a chronic wound - possibilities of identification on the basis of routine data].

Z Evid Fortbild Qual Gesundhwes 2019 Mar 12. Epub 2019 Mar 12.

PMV forschungsgruppe an der Medizinischen Fakultät und Uniklinik Köln, Universität zu Köln, Herderstraße 52, 50931 Köln, Deutschland.

Objective: There are still few epidemiological data on patients with chronic wounds (leg ulcers, diabetic foot ulcers and pressure ulcers). Statutory health insurance (SHI) data is increasingly being used for questions relating to healthcare science. When using this data, which is primarily collected for billing purposes, the methodological procedure for defining cases must be presented transparently. Read More

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http://dx.doi.org/10.1016/j.zefq.2019.02.004DOI Listing
March 2019
1 Read

Fatal squamous cell carcinoma from necrobiosis lipoidica diabeticorum in a diabetic patient.

Endocrinol Diabetes Metab Case Rep 2019 Mar 14;2019. Epub 2019 Mar 14.

Wolfson Diabetes Centre, Addenbrooke's Hospital Cambridge, Cambridge, UK.

Necrobiosis lipoidica diabeticorum (NLD) is a chronic granulomatous dermatitis generally involving the anterior aspect of the shin, that arises in 0.3-1.2% of patients with diabetes mellitus (1). Read More

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http://dx.doi.org/10.1530/EDM-19-0007DOI Listing
March 2019
6 Reads

The discovery and development of topical medicines for wound healing.

Expert Opin Drug Discov 2019 Mar 14:1-13. Epub 2019 Mar 14.

a Department of Medical Cell Biology , Uppsala University , Uppsala , Sweden.

Introduction: Chronic, nonhealing skin wounds claim >3% of the health-care budget in industrialized countries, and the incidence is rising. Currently, two parallel trends influence innovations within the field of wound healing: the need to reduce spread of antibiotic resistance and the emerging use of health economy and value-based models. Areas covered: This review focuses on the discovery of drug candidates and development of treatments aiming to enhance wound healing in the heterogeneous group of patients with nonhealing wounds. Read More

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https://www.tandfonline.com/doi/full/10.1080/17460441.2019.1
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http://dx.doi.org/10.1080/17460441.2019.1588879DOI Listing
March 2019
6 Reads

Cadexomer iodine effectively reduces bacterial biofilm in porcine wounds ex vivo and in vivo.

Int Wound J 2019 Mar 13. Epub 2019 Mar 13.

Department of Obstetrics and Gynecology, Institute for Wound Research, University of Florida, Gainesville, Florida.

Biofilms are prevalent in non-healing chronic wounds and implicated in delayed healing. Tolerance to antimicrobial treatments and the host's immune system leave clinicians with limited interventions against biofilm populations. It is therefore essential that effective treatments be rigorously tested and demonstrate an impact on biofilm across multiple experimental models to guide clinical investigations and protocols. Read More

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http://dx.doi.org/10.1111/iwj.13080DOI Listing
March 2019
3 Reads

The potential and limitations of induced pluripotent stem cells to achieve wound healing.

Stem Cell Res Ther 2019 Mar 12;10(1):87. Epub 2019 Mar 12.

Vascular Biology and Therapeutics Program and the Department of Surgery, Yale School of Medicine, Yale University, 10 Amistad Street, Room 437, PO Box 208089, New Haven, CT, 06520-8089, USA.

Wound healing is the physiologic response to a disruption in normal skin architecture and requires both spatial and temporal coordination of multiple cell types and cytokines. This complex process is prone to dysregulation secondary to local and systemic factors such as ischemia and diabetes that frequently lead to chronic wounds. Chronic wounds such as diabetic foot ulcers are epidemic with great cost to the healthcare system as they heal poorly and recur frequently, creating an urgent need for new and advanced therapies. Read More

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https://stemcellres.biomedcentral.com/articles/10.1186/s1328
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http://dx.doi.org/10.1186/s13287-019-1185-1DOI Listing
March 2019
3 Reads
3.368 Impact Factor

Use of Native Type I Collagen Matrix Plus Polyhexamethylene Biguanide for Chronic Wound Treatment.

Plast Reconstr Surg Glob Open 2019 Jan 15;7(1):e2047. Epub 2019 Jan 15.

Department of Surgery, Northwell Health, Lake Success, N.Y.

Background: Chronic wounds represent a significant financial burden to the healthcare system and a quality-of-life burden to patients. Many chronic wounds have elevated bioburden in the form of biofilm, which has been associated with delayed wound healing. This study examined the use of a native type I collagen matrix with the antimicrobial polyhexamethylene biguanide (PCMP) in the management of bioburden and treatment of chronic, nonhealing wounds over 12 weeks. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382242PMC
January 2019
1 Read

Vitamin D and diabetic foot ulcer: a systematic review and meta-analysis.

Nutr Diabetes 2019 Mar 11;9(1). Epub 2019 Mar 11.

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

We aimed to evaluate the association between vitamin D deficiency and diabetic foot ulcer (DFU) in patients with diabetes. Pubmed, EMBASE, BIOSIS, the Cochrane Library, and Web of Knowledge, last updated in July 2018, were searched. We assessed eligible studies for the association between vitamin D deficiency and DFU in diabetic patients. Read More

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http://www.nature.com/articles/s41387-019-0078-9
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http://dx.doi.org/10.1038/s41387-019-0078-9DOI Listing
March 2019
1 Read

Development and Validation of a Smartphone-Based Near-Infrared Optical Imaging Device to Measure Physiological Changes In-Vivo.

Micromachines (Basel) 2019 Mar 9;10(3). Epub 2019 Mar 9.

Optical Imaging Laboratory, Department of Biomedical Engineering, Florida International University, Miami, FL 33174, USA.

Smartphone-based technologies for medical imaging purposes are limited, especially when it involves the measurement of physiological information of the tissues. Herein, a smartphone-based near-infrared (NIR) imaging device was developed to measure physiological changes in tissues across a wide area and without contact. A custom attachment containing multiple multi-wavelength LED light sources (690, 800, and 840 nm; and <4 mW of optical power per LED), source driver, and optical filters and lenses was clipped onto a smartphone that served as the detector during data acquisition. Read More

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http://dx.doi.org/10.3390/mi10030180DOI Listing

Localised pressure stimulation using turf-like structures can improve skin perfusion in the foot.

Microcirculation 2019 Mar 10:e12543. Epub 2019 Mar 10.

School of Life Sciences and Education, Staffordshire University, Stoke-on-Trent, UK.

Objective: Improving perfusion under the skin can potentially reduce ulceration and amputation risk in people with diabetic foot. Localised pressure stimulation has been proven capable of improving skin perfusion in the scalp but its effectiveness for the foot has not been tested. In this study, localised pressure stimulation was realised using flexible turf-like structures with dense vertical fibres and their ability to increase perfusion was assessed. Read More

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http://doi.wiley.com/10.1111/micc.12543
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http://dx.doi.org/10.1111/micc.12543DOI Listing
March 2019
2 Reads

Contribution of 30-day readmissions to the increasing costs of care for the diabetic foot.

J Vasc Surg 2019 Mar 5. Epub 2019 Mar 5.

Diabetic Foot and Wound Service, The Johns Hopkins Hospital, Baltimore, Md; Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Md; Center for Surgical Trials and Outcomes Research, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Md. Electronic address:

Objective: The inpatient cost of care for diabetic foot ulcers (DFUs) has been estimated to be $1.4 billion annually in the United States. We have previously demonstrated that the risk of 30-day unplanned readmission for patients with DFU is nearly 22%. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07415214193017
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http://dx.doi.org/10.1016/j.jvs.2018.12.028DOI Listing
March 2019
2 Reads

Risk Factors Associated With Major Lower Extremity Amputation After Osseous Diabetic Charcot Reconstruction.

J Foot Ankle Surg 2019 Mar;58(2):295-300

Professor, Department of Plastic Surgery, MedStar Georgetown University Hospital, Washington DC. Electronic address:

Patients with diabetic Charcot neuroarthropathy (CN) are at high risk for ulcerations and major lower extremity amputations (LEAs). Osseous reconstruction is an important component in ulcer healing and prevention; however, despite such efforts, major LEAs remain a serious postreconstruction concern. The aim of this study was to identify risk factors for major LEA in patients who underwent osseous Charcot reconstruction. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.08.059DOI Listing
March 2019
1 Read

ADIE - nursing interventions of diabetic foot ulcer: An integrative review of the literature.

Curr Diabetes Rev 2019 03 7. Epub 2019 Mar 7.

Ramathibodi School of Nursing, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background And Aims: Diabetic foot ulcer is recognized as the consequence of peripheral neuropathy and peripheral arterial disease amid individuals with diabetes. As is well known, this situation still remains a crucial problem in nursing practice. Available studies describing an algorithm of inter-related nursing interventions concerned with diabetic foot ulcers are limited. Read More

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http://dx.doi.org/10.2174/1573399815666190307164119DOI Listing
March 2019
2 Reads

Hospitalists' Needs Assessment and Perceived Barriers in Wound Care Management: A Quality Improvement Project.

J Wound Ostomy Continence Nurs 2019 Mar/Apr;46(2):98-105

Cynthia A. Walker, MSN, RN, APRN-CNS, CWON, Interprofessional Practice & Patient Safety, Johns Hopkins Bayview Medical Center, Baltimore, Maryland. Alphonsa Rahman, DNP, APRN-CNS, CCRN, Interprofessional Practice & Patient Safety, Johns Hopkins Bayview Medical Center, Baltimore, Maryland. Trina L. Gipson-Jones, PhD, Hampton University, School of Nursing, Hampton, Virginia. Ché Matthew Harris, MD, MS, FACP, Department of General Internal Medicine, Johns Hopkins School of Medicine, Joint Appointment Johns Hopkins School of Nursing, Division of Hospital Medicine, Collaborative Inpatient Medicine Service, Baltimore, Maryland.

The purpose of this quality improvement project was to determine hospitalists' knowledge, practices, and perspectives related to management of pressure injuries and neuropathic/diabetic foot complications (having a foot ulcer or subsequent development of a foot infection because of a foot ulcer). We also sought to identify resources for and knowledge-based barriers to management of these wounds. This quality improvement effort targeted an interdisciplinary group of 55 hospitalists in internal medicine that consisted of 8 nurse practitioners, 10 physician assistants, and 38 physicians. Read More

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http://dx.doi.org/10.1097/WON.0000000000000512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407638PMC
March 2020
4 Reads

[Mid-Term Outcomes of Reconstruction of Charcot Foot Neuroarthropathy in Diabetic Patients].

Acta Chir Orthop Traumatol Cech 2019 ;86(1):51-57

Ortopedická klinika Fakultní nemocnice a Lékařské fakulty Univerzity Karlovy, Hradec Králové.

PURPOSE OF THE STUDY The aim of this study was to evaluate the mid-term outcomes of the surgical reconstruction of Charcot Foot Neuroarthropathy in diabetic patients with failed conservative treatment and indicated for a below-knee amputation. MATERIAL AND METHODS In the period from 2010 to 2015 the surgical reconstruction of inactive, chronic Charcot Foot Neuroarthropathy classified as type II and III by Sanders and Frykbeg was performed in 16 patients with failed conservative treatment. All these patients were by the diabetes centres initially indicated for a below-knee amputation. Read More

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January 2019
2 Reads

Effect of negative-pressure wound therapy on the circulating number of peripheral endothelial progenitor cells in diabetic patients with mild to moderate degrees of ischaemic foot ulcer.

Vascular 2019 Mar 6:1708538119836360. Epub 2019 Mar 6.

1 Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Objective: To investigate the effect of negative-pressure wound therapy (NPWT) on the circulating number of endothelial progenitor cells (EPCs) in diabetic patients with mild to moderate degrees of ischemic foot ulcer.

Methods: We selected 84 diabetic patients who had a foot ulcer with a duration of at least four weeks and who had an ankle-brachial index of 0.5-0. Read More

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http://dx.doi.org/10.1177/1708538119836360DOI Listing
March 2019
1 Read

A Meta-Analysis of the Outcomes of Split-Thickness Skin Graft on Diabetic Leg and Foot Ulcers.

Int J Low Extrem Wounds 2019 Mar 7:1534734619832123. Epub 2019 Mar 7.

1 Lebanese American University Medical Center-Rizk Hospital, Beirut, Lebanon.

Diabetic lower limb ulcers are a serious complication to diabetes that could lead to amputation and death. Split-thickness skin graft (STSG) has been proposed by some authors to treat noninfected diabetic wounds, mainly those found in the leg and on the dorsum of the foot. No quantitative evidence synthesis over this technique has been reported in the literature. Read More

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http://dx.doi.org/10.1177/1534734619832123DOI Listing
March 2019
2 Reads
1.194 Impact Factor

Efficacy and Safety of Low-Frequency, Noncontact Airborne Ultrasound Therapy (Glybetac) For Neuropathic Diabetic Foot Ulcers: A Randomized, Double-Blind, Sham-Control Study.

Int J Low Extrem Wounds 2019 Mar 5:1534734619832738. Epub 2019 Mar 5.

2 Maser India, Mumbai, India.

The diabetic foot ulcer (DFU) healing rates remain dismally low. Therefore, many adjunctive therapies have been evaluated including ultrasound therapy. The prior studies with noncontact, low-frequency ultrasound were retrospective, single arm, unblinded, or with historical controls. Read More

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http://dx.doi.org/10.1177/1534734619832738DOI Listing
March 2019
2 Reads

Adjuvant Hyperbaric Oxygen Therapy Enhances Healing of Nonischemic Diabetic Foot Ulcers Compared With Standard Wound Care Alone.

Int J Low Extrem Wounds 2019 Mar 5:1534734619829939. Epub 2019 Mar 5.

1 Physical Medicine, Rheumatology and Rehabilitation Department, Tanta University Hospitals, Tanta, Egypt.

Recent systematic reviews and meta-analyses have produced conflicting results about the efficacy of hyperbaric oxygen therapy (HBOT) in improving the healing rate for chronic diabetic foot wounds. This study aimed to assess the efficacy of systemic HBOT in healing of chronic nonischemic diabetic foot ulcer. Thirty adult patients having Wagner's grade 2 or 3 chronic diabetic foot ulcers, in whom the response to 30 days of standard wound care was not favorable, were prospectively randomized to have either HBOT (20-40 sessions) plus conventional treatment (n = 15) or conventional treatment alone (n = 15). Read More

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http://dx.doi.org/10.1177/1534734619829939DOI Listing
March 2019
3 Reads

Major lower limb amputations in Far North Queensland.

ANZ J Surg 2019 Mar 5. Epub 2019 Mar 5.

Department of Surgery, Cairns Hospital, Cairns, Queensland, Australia.

Background: Major lower limb amputation is a devastating operation most commonly performed for complications of peripheral artery disease or diabetes mellitus. Data suggest that there is a widespread variation in major amputation rates within and between countries. This study aimed to identify key characteristics of patients undergoing this procedure in our region, and to compare our population to the rest of Australia. Read More

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http://dx.doi.org/10.1111/ans.15031DOI Listing
March 2019
2 Reads

[Indications and application of extracorporeal shockwave therapy].

Ugeskr Laeger 2019 Feb;181(8)

Extracorporeal shockwave therapy (ESWT) is a novel treatment modality to stimulate tissue regeneration and anti-fibrosis. In this review, we summarise the use of ESWT for erectile dysfunction (ED), diabetic foot ulcers (DFU), Peyronie's disease (PD), chronic kidney disease (CKD), and scleroderma. Several randomised clinical trials demonstrate the efficacy of ESWT for vasculogenic ED and DFU, and ESWT may also relieve pain in patients with PD. Read More

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February 2019

The role of microRNAs in the healing of diabetic ulcers.

Int Wound J 2019 Feb 28. Epub 2019 Feb 28.

Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

MicroRNAs (miRNAs) are small protected molecules with a length of 18 to 25 nucleotides. Many studies have recently been conducted on miRNAs, illustrating their role in regulating many biological, physiological, and pathological activities, such as maintaining cellular signalling and regulating cellular pathways. The main role of miRNAs is to regulate the expression of genes after translation, which can lead to the destruction or suppression of translation by binding to mRNAs. Read More

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http://doi.wiley.com/10.1111/iwj.13070
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http://dx.doi.org/10.1111/iwj.13070DOI Listing
February 2019
4 Reads
2.023 Impact Factor

Potential prognostic factors for delayed healing of common, non-traumatic skin ulcers: A scoping review.

Int Wound J 2019 Feb 28. Epub 2019 Feb 28.

NIHR Greater Manchester Patient Safety Translational Research Centre, The University of Manchester, Manchester, UK.

Healing of non-traumatic skin ulcers is often suboptimal. Prognostic tools that identify people at high risk of delayed healing within the context of routine ulcer assessments may improve this, but robust evidence on which factors to include is lacking. Therefore, we scoped the literature to identify which potentially prognostic factors may warrant future systematic reviews and meta-analyses. Read More

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http://dx.doi.org/10.1111/iwj.13100DOI Listing
February 2019
2 Reads

Clinical Profile and Outcome in Patients of Diabetic Foot Infection.

Int J Appl Basic Med Res 2019 Jan-Mar;9(1):14-19

Department of Internal Medicine, All India Institute of Medical Sciences, New Delhi, India.

Purpose: The aim is to study the clinical profile and outcome of patients presenting with diabetic foot infections (DFI).

Methods: This was a prospective study recruiting patients >18 years of age, with DFI. All patients underwent a detailed history and clinical examination. Read More

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http://dx.doi.org/10.4103/ijabmr.IJABMR_278_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385536PMC
March 2019
2 Reads

Continuous Movement Monitoring of Daily Living Activities for Prevention of Diabetic Foot Ulcer: A Review of Literature.

Int J Prev Med 2019 12;10:22. Epub 2019 Feb 12.

Department of Clinical and Experimental Medicine, University of Florence, Florence, Italy.

Lower extremity ulcers represent the most ominous, feared, and costly complications of diabetes mellitus. The aim of this review is to highlight the role of daily life physical activities (PAs) and continuous movement monitoring (CMM) in the prevention of foot ulcers. Peripheral neuropathy and peripheral vascular disease are the main causes of foot ulceration and contribute, in turn, to the development of additional risk factors such as foot deformities and/or joint and muscular alterations. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_410_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390424PMC
February 2019
1 Read

Strong association between vibration perception thresholds at low frequencies (4 and 8 Hz), neuropathic symptoms and diabetic foot ulcers.

PLoS One 2019 28;14(2):e0212921. Epub 2019 Feb 28.

Department of Translational Medicine-Hand Surgery, Lund University, Malmö, Sweden.

Aims: To investigate whether multi-frequency measurement of vibration perception thresholds (VPTs) can identify individuals with a high risk of developing diabetic foot ulcer or neuropathic symptoms.

Methods: VPTs were measured at six different frequencies (4, 8, 16, 32, 64 and 125 Hz) on metatarsal heads 1 and 5 on the sole of the foot using a standard VibroSense Meter device in 535 type 1 diabetic (T1DM) patients and 717 non-diabetic control subjects. VPTs in control subjects were used to establish normal values for five different age groups for male and female subjects respectively. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212921PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394961PMC
February 2019

Management of diabetic foot ulcers in the community: an update.

Br J Community Nurs 2019 Mar;24(Sup3):S14-S19

School of Human and Health Sciences, University of Huddersfield.

Diabetic foot ulceration is costly, both in terms of NHS expenditure and quality of life for the patient. This article reviews the guidelines for assessment and management of the diabetic foot ulcer and provides instruction on undertaking vascular and neurological assessments of the diabetic foot. Wound assessment, with an overview of the TEXAS and SINBAD wound classification systems, is also explored, as is the importance of the 1 working day referral for expert assessment for any new diabetic foot ulcer in order to reduce wound complications, length of hospital stay and, ultimately, amputation. Read More

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http://dx.doi.org/10.12968/bjcn.2019.24.Sup3.S14DOI Listing

Roxadustat promotes angiogenesis through HIF-1α/VEGF/VEGFR2 signaling and accelerates cutaneous wound healing in diabetic rats.

Wound Repair Regen 2019 Feb 28. Epub 2019 Feb 28.

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Yishan Rd 600, Shanghai 200233, PR China.

Diabetic foot ulcers are a major health-care burden worldwide. One primary cause of the delayed wound healing in diabetic patients is impaired function of the hypoxia-inducible factor-1α/vascular endothelial growth factor (HIF-1α/VEGF) axis, which results in compromised neovascularization in response to hypoxia. In the present study, we aimed to investigate the effect of roxadustat, a novel HIF prolyl-4-hydroxylase inhibitor, on angiogenesis and its therapeutic effect on cutaneous wound healing in diabetic rats. Read More

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http://dx.doi.org/10.1111/wrr.12708DOI Listing
February 2019
3 Reads

Impaired quality of life and diabetic foot disease in Saudi patients with type 2 diabetes: A cross-sectional analysis.

Authors:
Sana A AlSadrah

SAGE Open Med 2019 21;7:2050312119832092. Epub 2019 Feb 21.

Department of Preventive Medicine, Governmental Hospital Khobar, Health Centers in Khobar, Ministry of Health, Khobar, Saudi Arabia.

Objectives: This study aimed to assess the overall health-related quality of life in type 2 diabetes mellitus patients with diabetic foot disease compared to diabetic patients without diabetic foot and to identify the clinical utility of this assessment.

Methods: A total of 250 consecutive patients with type 2 diabetes mellitus (100/150 with/without diabetic foot, respectively) were interviewed. The questionnaires of the 36-item short-form survey and region-specific foot and ankle ability measure were applied. Read More

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http://dx.doi.org/10.1177/2050312119832092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385329PMC
February 2019
1 Read

Serum vitamin D and diabetic foot complications.

Diabet Foot Ankle 2019 19;10(1):1579631. Epub 2019 Feb 19.

Department of Orthopaedic Surgery, UT Southwestern Medical Center, Dallas, TX, USA.

: Foot complications such as ulceration and neuropathy are common complications of diabetes mellitus (DM). Previous reports have demonstrated a possible increased risk of these complications in diabetic patients with low levels of serum vitamin D.: The purpose of this study is to compare serum vitamin D levels in diabetic patients with and without Charcot neuroarthropathy (CN), peripheral arterial disease (PAD), infection (DFI), ulceration (DFU), and peripheral neuropathy (DPN). Read More

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http://dx.doi.org/10.1080/2000625X.2019.1579631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383621PMC
February 2019
3 Reads

Review of Diabetic Polyneuropathy: Pathogenesis, Diagnosis and Management According to the Consensus of Egyptian Experts.

Curr Diabetes Rev 2019 Feb 26. Epub 2019 Feb 26.

Faculty of Medicine, Alexandria University. Egypt.

Diabetic polyneuropathy (DPN) is a complex and multifactorial entity in which various factors besides hyperglycemia play an important role. Symptoms of DPN are sensory, motor or autonomic. Intensive research proved that oxidative stress is the common denominator for the four major destructive pathways of hyperglycemia including increased hexosamine pathway flux, activation of Protein kinase-C (PKC) pathway, increased Advanced Glycated End-products (AGEs) formation, and increased Polyol Pathway flux. Read More

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http://dx.doi.org/10.2174/1573399815666190226150402DOI Listing
February 2019
6 Reads

Human Wounds and Its Burden: An Updated Compendium of Estimates.

Authors:
Chandan K Sen

Adv Wound Care (New Rochelle) 2019 Feb 13;8(2):39-48. Epub 2019 Feb 13.

Department of Surgery, Indiana University Health Comprehensive Wound Center, Indianapolis, Indiana.

A 2018 retrospective analysis of Medicare beneficiaries identified that ∼8.2 million people had wounds with or without infections. Medicare cost estimates for acute and chronic wound treatments ranged from $28. Read More

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http://dx.doi.org/10.1089/wound.2019.0946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389759PMC
February 2019
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Argon Mitigates Impaired Wound Healing Process and Enhances Wound Healing and .

Theranostics 2019 1;9(2):477-490. Epub 2019 Jan 1.

Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea & Westminster Hospital, London, UK.

Diabetic foot ulcers are associated with significant morbidity and mortality, and current treatments are far from optimal. Chronic wounds in diabetes are characterised by impaired angiogenesis, leukocyte function, fibroblast proliferation, and keratinocyte migration and proliferation. : We tested the effect of exposure to argon gas on endothelial cell, fibroblast, macrophage and keratinocyte cell cultures and of a streptozotocin-induced diabetic mouse model. Read More

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http://dx.doi.org/10.7150/thno.29361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376177PMC
January 2019
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Human Umbilical Cord-Derived Stem Cells: Isolation, Characterization, Differentiation, and Application in Treating Diabetes.

Crit Rev Biomed Eng 2018 ;46(5):399-412

School of Regenerative Medicine, Manipal Academy of Higher Education, Bangalore, India; Dr. D.Y. Patil Vidyapeeth Homeopathic Medical College and Research Centre, Sant Tukaram Nagar, Pimpri, Pune, India.

Stem cell therapy is one of the most promising and effective approaches for treating diabetes, due to stem cell nonimmunogenic and nonimmunosupressive properties. Mesenchymal stem cells (MSCs) derived from human umbilical cord have been widely used in cell-based therapies for clinical applications. Among their various properties, immunomodulatory and proregenerative capacities broaden their scope for treating diabetes. Read More

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http://dx.doi.org/10.1615/CritRevBiomedEng.2018027377DOI Listing
January 2018
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Trends in Foot and Ankle Studies Published in High-Impact General Medical Journals: A Systematic Review.

J Foot Ankle Surg 2019 Feb 22. Epub 2019 Feb 22.

Assistant Professor and Chief, Orthopaedic Foot & Ankle Service, Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA. Electronic address:

The foot and ankle surgery literature lacks an analysis of studies published in general medical journals. Studies published in general medical journals have high visibility and significant impact on decision making by medical practitioners and health care policy makers. Knowledge of the subject matter and methodologic characteristics of foot and ankle publications being read by general medical practitioners and the lay public is important to the practicing foot and ankle surgeon. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.09.005DOI Listing
February 2019
2 Reads

A Novel Recombinant Human Collagen-based Flowable Matrix for Chronic Lower Limb Wound Management: First Results of a Clinical Trial.

Wounds 2019 Feb 14. Epub 2019 Feb 14.

Department of Plastic Surgery, Assaf Harofeh Medical Center, Zerifin, Israel.

Background: Chronic ulcers pose a significant health concern and economic burden. Numerous products, including animal-derived collagen products, have been designed to provide the injured site with a biocompatible structural matrix that promotes tissue regeneration. Yet, animal-derived collagens can evoke immune responses, bear risk of disease transmission, and fail to closely mimic the function of native collagen. Read More

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February 2019
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Factors Associated with Health-Related Quality of Life among Jordanian Patients with Diabetic Foot Ulcer.

J Diabetes Res 2019 17;2019:4706720. Epub 2019 Jan 17.

The National Center for Diabetes, Endocrinology and Genetics, Amman, Jordan.

Objective: This study is aimed at determining factors associated with the quality of life among Jordanian diabetic patients with foot ulcers.

Methods: 144 consecutive patients with diabetic foot ulcers aged ≥ 18 years who were attending the diabetic foot clinic at a diabetes-specialized center were included in this study. Health-related quality of life was assessed using two self-administered questionnaires: Diabetic Foot Scale-Short Form (DFS-SF) and Short Form-8 (SF-8). Read More

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http://dx.doi.org/10.1155/2019/4706720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360050PMC
January 2019
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[Influence of cluster nursing intervention on inadequate drainage in vacuum sealing drainage for inpatients in burn unit].

Zhonghua Shao Shang Za Zhi 2019 Feb;35(2):148-152

Nurse Department, the First Affiliated Hospital, Air Force Military Medical University, Xi'an 710032, China.

To explore the influence of cluster nursing intervention on inadequate drainage in vacuum sealing drainage (VSD) for inpatients in burn unit. From October to December 2016, 60 patients, aged (43.6±2. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2019.02.011DOI Listing
February 2019

Translation and validation of the Korean version of the Diabetic Foot Ulcer Scale-Short Form.

Authors:
Ye-Na Lee

Int Wound J 2019 Mar;16 Suppl 1:3-12

Department of Nursing, College of Nursing, Korea University, Seoul, Republic of Korea.

The purpose of this study was to translate the Diabetic Foot Ulcer Scale-Short Form (DFS-SF) into Korean and evaluate its psychometric performance in patients with diabetic foot ulcers (DFUs). The DFS-SF was translated into Korean using translation guidelines from the World Health Organization. The Korean version of DFS-SF (DFS-SF-K) went through the full linguistic validation process and was evaluated in 320 Korean patients with DFU. Read More

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http://dx.doi.org/10.1111/iwj.13025DOI Listing
March 2019
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Implementation of the Champions for Skin Integrity Model to improve leg and foot ulcer care in the primary health care setting.

J Clin Nurs 2019 Feb 21. Epub 2019 Feb 21.

Faculty of Health Institute of Health & Biomedical Innovation Queensland University of Technology, 60 Musk Ave, Kelvin Grove, QLD 4059, Australia.

Aims: To facilitate evidence-based leg and foot ulcer management through implementation of the Champions for Skin Integrity (CSI) model to education in primary health care in Australia.

Background: Leg and foot ulcers are frequently seen wounds in general practice and wound care the most frequently performed activity by practice nurses. Literature reports the lack of evidence based leg and foot ulcer assessment, management and prevention strategies in this setting and previous research in regards to confidence and knowledge has indicated that general practice health professionals have the greatest need for education in wound care. Read More

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http://dx.doi.org/10.1111/jocn.14826DOI Listing
February 2019

Risk factors for mortality among patients undergoing major amputations due to infected diabetic feet.

J Vasc Bras 2018 Oct-Dec;17(4):296-302

Universidade Federal de Minas Gerais - UFMG, Departamento de Cirurgia, Belo Horizonte, MG, Brasil.

Background: Foot ulcers in patients with diabetes are a major public health problem and are often associated with lower limbs amputation and mortality in this population.

Objectives: To investigate the risk factors associated with mortality in patients with infected diabetic foot ulcers and major lower limb amputations.

Methods: This was an observational, retrospective, case-control study with a sample of 78 patients with infected diabetic foot ulcers who had major lower limb amputations at a Vascular Surgery Service at a university hospital. Read More

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http://dx.doi.org/10.1590/1677-5449.010717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375264PMC
February 2019

Lower limb wounds in diabetic and non-diabetic patients: survival analysis.

Rev Gaucha Enferm 2019 Feb 18;40:e20180016. Epub 2019 Feb 18.

Universidade Federal de Minas Gerais (UFMG). Escola de Enfermagem. Belo Horizonte, Minas Gerais , Brasil.

Objective: To evaluate the survival of wounds in lower limbs of diabetic and non-diabetic patients.

Method: Retrospective cohort study of patients with lower limb ulcers treated at a specialized center between 2011 and 2013. Outcome: healing of lower limb injuries in days. Read More

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http://dx.doi.org/10.1590/1983-1447.2019.20180016DOI Listing
February 2019
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