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Adv Wound Care (New Rochelle) 2022 May 20. Epub 2022 May 20.

SerenaGroup, CEO/Medical Director, 90 Sherman St, Cambridge, Massachusetts, United States, MA;

Objective: To conduct a systematic review and meta-analysis of recently published randomized controlled trials (RCTs) that employed the use of topical oxygen therapy as an adjunct therapy in the treatment of Wagner 1 and 2 diabetic foot ulcers Approach: Following a literature search of eligible studies from 2010 onward, 4 RCTs were included. Studies were analyzed for patient and wound characteristics, outcomes, risk of bias, and quality of the evidence assessed using the GRADE methodology. A random effects meta-analysis for complete wound healing was carried out due to statistical heterogeneity of included studies. Read More

World J Plast Surg 2022 Mar;11(1):12-22

Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Diabetes is one of the metabolic diseases characterized by hyperglycemia, with many complications. Diabetic foot ulcer (DFU) is a significant complication of diabetes. Various therapy procedures have been recently described for DFU improvement. Read More

Comput Biol Med 2022 May 5;146:105582. Epub 2022 May 5.

Hong Kong Community College, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

More than 422 million people worldwide suffered from diabetes mellitus (DM) in 2021. Diabetic foot is one the most critical complications resultant of DM. Foot ulceration and infection are frequently arisen, which are associated with changes in the mechanical properties of the plantar soft tissues, peripheral arterial disease, and sensory neuropathy. Read More

PLoS One 2022 19;17(5):e0268242. Epub 2022 May 19.

Diabetology Department, Centre Hopitalier Sud Francilien, Corbeil-Essonnes, France.

The rate of recurrence for diabetic foot ulcer (DFU) is 50% at 2 years Armstrong DG, 2017. International recommendations call for regular monitoring to prevent DFU recurrence. We aim to investigate the relation between post-healing follow-up and recurrence rates. Read More

Orthop Surg 2022 May 19. Epub 2022 May 19.

Orthopaedic Surgery, Nova Southeastern University Osteopathic Medicine College of Medicine, Ft. Lauderdale, Florida, USA.

Charcot arthropathy is an insidious condition affecting the lower limbs of diabetic patients. It is a complication of diabetic neuropathy resulting from subsequent Wallerian degeneration of the nerves. This complication may eventually lead to limb amputation and a poor patient prognosis if not diagnosed and treated successfully. Read More

Front Bioeng Biotechnol 2022 2;10:869408. Epub 2022 May 2.

Laboratorio di Biologia Molecolare e Cellulare, IDI-IRCCS, Roma, Italy.

Cutaneous chronic wounds are a major global health burden in continuous growth, because of population aging and the higher incidence of chronic diseases, such as diabetes. Different treatments have been proposed: biological, surgical, and physical. However, most of these treatments are palliative and none of them can be considered fully satisfactory. Read More

Int J Low Extrem Wounds 2022 May 18:15347346221102643. Epub 2022 May 18.

60259Department of Systems Medicine, 9318University of Rome "Tor Vergata", Rome, Italy.

Diabetic foot osteomyelitis (DFO) is a clinical problem with high risk of amputation. The treatment of DFO is still an unsolved challenge. Surgical therapy, antibiotic therapy or conservative treatment are still debated for the timing and the consequences. Read More

Cir Esp (Engl Ed) 2022 May 15. Epub 2022 May 15.

Unidad de Cirugía de Pared Abdominal, Hospital Universitari i Politècnic La Fe, Universidad de Valencia, Valencia, Spain.

Negative pressure wound therapy (NPWT) is widely known in surgical practice. The initial indications for NPWT were chronic wounds, especially diabetic foot, vascular and decubitus ulcers, and infected traumatic wounds. Nowadays, the use has been widely increased. Read More

Rev Lat Am Enfermagem 2022 ;30:e3567

Universidade Estadual do Ceará, Fortaleza, CE, Brasil.

Objective: to analyze the effect of cutaneous foot thermometry in people with Diabetes Mellitus, compared with the standard prevention of foot ulcers adopted in these patients.

Method: a systematic review with meta-analysis. Protocol registered with PROSPERO (CRD42020202686). Read More

Growth Factors 2022 May 18:1-16. Epub 2022 May 18.

Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.

Angiogenesis is a critical step of wound healing, and its failure leads to chronic wounds. The idea of restoring blood flow to the damaged tissues by promoting neo-angiogenesis is lucrative and has been researched extensively. Vascular endothelial growth factor (VEGF), a key dynamic molecule of angiogenesis has been investigated for its functions. Read More

J Tissue Viability 2022 May 7. Epub 2022 May 7.

School of Public Health, Nantong University, Nantong, China. Electronic address:

Background: Accurate identification of diabetic foot ulcer infection (IDFU) through inflammatory markers is still a challenge in clinical practice.

Objectives: This meta-analysis aims to investigates whether there is a significant indigenous association between CRP level and diabetic foot ulcer infection.

Methods: The studies on the diagnosis of IDFU by inflammatory marker C-reactive protein published before November 2021 in PubMed, Web of Science, Embase, and Cochrane Library were searched. Read More

J Wound Care 2022 May;31(5):432-434

Deptartment of Microbiology, MIMSR Medical College, Latur-413 531, M.S., India.

Diabetic leg ulcers are difficult to manage. Infection by bacterial pathogens, such as meticillin-resistant (MRSA), is one of the most important reasons for non-healing of ulcers. If not treated in a timely manner, the ulceration may progress to septicaemia, amputation and even death. Read More

Int J Low Extrem Wounds 2022 May 16:15347346221099798. Epub 2022 May 16.

Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, 104560James Cook University, Townsville, Queensland, Australia.

This study explored health professionals' perceptions of current issues and opportunities for the secondary prevention of diabetes-related foot disease (DFD), and potential strategies for improving DFD care. From May to October 2020, relevant Australian health professionals completed an online survey which used ordinal scales, ranking questions, and open text fields to assess perceptions about the importance of aspects of secondary prevention for DFD and elements for a prevention program. Quantitative data were summarised and compared between professions using non-parametric tests, and qualitative data was analysed using conceptual content analysis to identify emerging themes. Read More

Foot (Edinb) 2021 Oct 27;52:101878. Epub 2021 Oct 27.

Department of Endocrinology, Silverline Hospital, Kochi, India.

Introduction: Diabetic foot osteomyelitis (DFO) is a dreaded complication as both diagnosis and treatment of the condition is laborious. However, for proper decision on antibiotics in medical management of DFO, accurate determination of microbes is necessary to narrow the spectrum of coverage and to reduce adverse effects of long-term administration of antibiotics. With differing pattern of use of antimicrobials and their resistance pattern in different countries, it is empirical to determine the microbiological characteristics of bone cultures in DFO from a referral institute in South India. Read More

J Wound Care 2022 May;31(Sup5):S3-S4

University of Pittsburgh Medical Center; Director of Blair Medical Associates, UPMC Wound Clinic, Altoona, PA, US.

Evid Based Complement Alternat Med 2022 6;2022:2577601. Epub 2022 May 6.

Department of Endocrinology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou 570311, Hainan, China.

Objective: Discuss the effectiveness and value of micropower vacuum dressing (MVD) in promoting the healing of I-II grades diabetic foot wounds.

Methods: Sixty patients diagnosed with diabetic foot ulcers and Wagner grades I-II were selected and randomly divided into the control group and experimental group, with 30 cases in each group. The control group was covered with conventional treatments and petrolatum gauze dressings, and the experimental group was treated with MVD on the basis of conventional reatments. Read More

Stem Cells Int 2022 5;2022:2976185. Epub 2022 May 5.

Department of Limbs (Foot and Hand) Microsurgery, Affiliated Chenzhou Hospital, Hengyang Medical School, University of South China, Chenzhou, China.

Diabetes foot ulcer (DFU) is a serious complication of diabetes, characterized by impaired vascular function, limited angiogenesis, and chronic inflammation. Direct stem cell injection on treating DFU is far from satisfactory in clinical practice, as this therapy neither protects nor localizes the injected cell suspension at the chronic ulcer site. Meanwhile, most of injected cells gradually perished within several days due to senescence or apoptosis. Read More

BMJ Open 2022 May 13;12(5):e057230. Epub 2022 May 13.

Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.

Purpose: To investigate health, mortality and healthcare inequalities experienced by people with intellectual disabilities, and autistic people, and their determinants; an important step towards identifying and implementing solutions to reduce inequalities. This paper describes the cohorts, record-linkages and variables that will be used.

Participants: Scotland's Census, 2011 was used to identify Scotland's citizens with intellectual disabilities, and autistic citizens, and representative general population samples with neither. Read More

Can J Diabetes 2022 Apr 10;46(3):313-327. Epub 2021 Jul 10.

Department of Nursing, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada.

Background: Being physically active on a regular basis has a favourable impact on diabetes-related complications. With the exception of evidence advising individuals with an active diabetic foot ulceration (DFU) to avoid weight-bearing activity, no physical activity (PA) recommendations are currently provided for this population.

Objective: The aim of this scoping review was to examine and map the existing research evidence of PA participation for individuals with an active DFU. Read More

APMIS 2022 May 14. Epub 2022 May 14.

Department of Immunology and Microbiology, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.

Background And Purpose: Clinicians and researchers utilize subjective, clinical classification systems to stratify lower extremity ulcer infections for treatment and research. The purpose of this study was to examine whether these clinical classifications are reflected in the ulcer's transcriptome.

Methods: RNA-sequencing (RNA-seq) was performed on biopsies from clinically infected lower extremity ulcers (n = 44). Read More

Int Wound J 2022 May 14. Epub 2022 May 14.

Xiangya School of Nursing School of Central South University, Hunan, China.

A meta-analysis was performed to evaluate the association between vitamin D deficiency and diabetic foot ulcer wounds in diabetic subjects. A systematic literature search up to March 2022 incorporated 7586 subjects with diabetes mellitus at the beginning of the study; 1565 were using diabetic subjects with foot ulcer wounds, and 6021 were non-ulcerated diabetic subjects. Statistical tools like the dichotomous and contentious method were used within a random or fixed-influence model to establish the odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) to evaluate the influence of vitamin D deficiency in managing diabetic foot ulcer wound. Read More

J Clin Med 2022 Apr 27;11(9). Epub 2022 Apr 27.

Epidemiology Unit, Agenzia Regionale Sanità, 50141 Florence, Italy.

The aim of this study was to evaluate the risk of death after hospitalizations for diabetic foot (DF) complications, comparing two different cohorts of people with or without a prior history of DF hospitalizations across the years 2011 to 2018 in Tuscany, Italy. The DF complications were categorized by administrative source datasets such as: amputations (both major and minor), gangrene, ulcers, infections, Charcot and revascularizations. A further aim was to present the trend over time of the first ever incidents of diabetic foot hospitalizations in Tuscany. Read More

Am J Transl Res 2022 15;14(4):2452-2460. Epub 2022 Apr 15.

Wound Stoma Care Outpatient Center, The First Affiliated Hospital of Anhui Medical University Hefei 230022, Anhui, China.

Objective: To investigate the effects of silver foam combined with Dermlin wound healing dressing on concentrations of inflammatory factors of wound surface and quality of life of the patients with diabetic lower limb ulcers.

Methods: A total of 60 patients with diabetic lower limb ulcers admitted to the First Affiliated Hospital of Anhui Medical University during January 2020 and December 2020 were retrospectively enrolled in this study. According to the different treatments, they were divided into a control group (30 cases treated with Dermlin wound healing dressing only), and a research group (30 cases treated with silver foam combined with Dermlin dressing). Read More

Front Vet Sci 2022 26;9:879630. Epub 2022 Apr 26.

Large Animal Clinical Sciences, University of Tennessee College of Veterinary Medicine, Knoxville, TN, United States.

Osteomyelitis is an inflammatory bone disease typically caused by infectious microorganisms, often bacteria, which causes progressive bone destruction and loss. The most common bacteria associated with chronic osteomyelitis is . The incidence of osteomyelitis in the United States is estimated to be upwards of 50,000 cases annually and places a significant burden upon the healthcare system. Read More

BMJ Open Diabetes Res Care 2022 May;10(3)

George & Fay Yee Centre for Healthcare Innovation, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.

Introduction: Healing time for neuropathic planter foot ulcers (NPFUs) in persons with diabetes may be reduced through use of non-removable fiberglass total contact casting (F-TCC) compared with removable cast walkers (RCWs), although the evidence base is still growing.

Research Design And Methods: We conducted a rapid review and systematically searched for, and critically assessed, randomized controlled trials (RCTs) that compared the efficacy of F-TCC versus RCW, focusing on the time to ulcer healing in adult persons (18+ years) with NPFUs and type 1 or type 2 diabetes. We meta-analysed the mean differences and associated 95% CIs using an inverse variance, random-effects model. Read More

Diabetol Metab Syndr 2022 May 12;14(1):70. Epub 2022 May 12.

Department of Neurology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, Fujian, China.

Diabetic foot is one of the most serious and painful chronic complications of diabetic patients, especially elderly diabetic patients. It has a high rate of death, disability and amputation. Obstructive sleep apnea (OSA) is a treatable chronic sleep disorder. Read More

BMC Endocr Disord 2022 May 11;22(1):124. Epub 2022 May 11.

Department of Surgical Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Diabetes mellitus is emerging as a major worldwide health problem that has a social, financial, and developmental impact on developing countries. Foot complications are among the most serious and costly complications of diabetes which lead to lower extremity amputation due to diabetic foot ulcers. Poor diabetic foot self-care practice is identified by different studies as a major contributing factor to diabetic foot ulcers. Read More

Int J Low Extrem Wounds 2022 May 12:15347346221096205. Epub 2022 May 12.

Medical Department, 27241Hospital of Thun, Thun, Switzerland.

Inadequate response to wound management is defined as a reduction in the wound area of <40-50% following four weeks of standard of care (SOC) and should be managed with a skin substitute product. We set out to evaluate a novel outcome-based model focusing on the management of hard-to-heal venous leg ulcers (VLUs) and diabetic foot ulcers (DFUs) using SOC treatment or intact fish skin grafts (FSGs) in a regional hospital. We built an outcome-based model applying surrogate markers and endpoints of wound healing for VLU and DFU to determine the healing trajectory with SOC treatment. Read More

Sci Transl Med 2022 May 11;14(644):eabg8397. Epub 2022 May 11.

Wound Healing and Regenerative Medicine Research Program, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.

Despite the hyperproliferative environment marked by activation of β-catenin and overexpression of , the epidermis surrounding chronic diabetic foot ulcers (DFUs) is clinically hypertrophic and nonmigratory yet does not undergo malignant transformation. We identified miR193b-3p as a master regulator that contributes to this unique cellular phenotype. We determined that induction of tumor suppressor miR193b-3p is a unique feature of DFUs that is not found in venous leg ulcers, acute wounds, or cutaneous squamous cell carcinoma (SCC). Read More

Am J Case Rep 2022 May 11;23:e936359. Epub 2022 May 11.

Medical Department of Urgo Medical, Barcelona, Spain.

BACKGROUND Healico© is an innovative smartphone application designed to assist healthcare professionals in managing wounds in their daily practice. The application records all clinical information of the wound, facilitating its monitoring, and may lead to the selection of the best treatment for the patient. In addition, the application allows secure data sharing among healthcare professionals. Read More