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    1 OF 133

    Evaluation of the effectiveness and cost-effectiveness of lightweight fibreglass heel casts in the management of ulcers of the heel in diabetes: a randomised controlled trial.
    Health Technol Assess 2017 May;21(34):1-92
    Swansea Centre for Health Economics, College of Human and Health Science, Swansea University, Swansea, UK.
    Background: Ulcers of the foot in people with diabetes mellitus are slow to heal and result in considerable cost and patient suffering. The prognosis is worst for ulcers of the heel.

    Objective: To assess both the clinical effectiveness and the cost-effectiveness of lightweight fibreglass casts in the management of heel ulcers. Read More

    Microscopy visualisation confirms multi-species biofilms are ubiquitous in diabetic foot ulcers.
    Int Wound J 2017 Jun 23. Epub 2017 Jun 23.
    Surgical Infection Research Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.
    Increasing evidence within the literature has identified the presence of biofilms in chronic wounds and proposed that they contribute to delayed wound healing. This research aimed to investigate the presence of biofilm in diabetic foot ulcers (DFUs) using microscopy and molecular approaches and define if these are predominantly mono- or multi-species. Secondary objectives were to correlate wound observations against microscopy results in ascertaining if clinical cues are useful in detecting wound biofilm. Read More

    [Surgical treatment of diabetic neuroosteoarthropathy (DNOAP) and its long-term results].
    Khirurgiia (Mosk) 2017 (6):41-50
    Bryukhovetskaya Central Regional Hospital, Krasnodar Territory, Russia.
    Aim: To develop pathogenetically justified surgical treatment of diabetic neuroosteoarthropathy (DNOAP).

    Material And Methods: 52 patients were operated and long-term results were studied in 36 of them. 2 groups were assessed depending on completeness of surgical treatment including changed synovial structures removal. Read More

    "FootSnap": A New Mobile Application for Standardizing Diabetic Foot Images.
    J Diabetes Sci Technol 2017 Jun 1:1932296817713761. Epub 2017 Jun 1.
    2 School of Healthcare Science, Faculty of Science & Engineering, Manchester Metropolitan University, Manchester, UK.
    Background: We describe the development of a new mobile app called "FootSnap," to standardize photographs of diabetic feet and test its reliability on different occasions and between different operators.

    Methods: FootSnap was developed by a multidisciplinary team for use with the iPad. The plantar surface of 30 diabetic feet and 30 nondiabetic control feet were imaged using FootSnap on two separate occasions by two different operators. Read More

    Annual direct medical costs associated with diabetes-related complications in the event year and in subsequent years in Hong Kong.
    Diabet Med 2017 Jun 21. Epub 2017 Jun 21.
    Departments of Family Medicine and Primary Care, University of Hong Kong, Ap Lei Chau, Hong Kong.
    Aim: To develop models to estimate the direct medical costs associated with diabetes-related complicationsin the event year and in subsequent years.

    Methods: The public direct medical costs associated with 13 diabetes-related complications were estimated among a cohort of 128 353 people with diabetes over 5 years. Private direct medical costs were estimated from a cross-sectional survey among 1825 people with diabetes. Read More

    Ominous triad triggered by high-dose glucocorticosteroid therapy.
    BMJ Case Rep 2017 Jun 18;2017. Epub 2017 Jun 18.
    Division of Internal Medicine, Hospital Tiefenau, Inselgruppe AG, University of Bern, Bern, Switzerland.
    Glucocorticosteroids (CS) play a key role in the treatment of numerous diseases. Nonetheless, they can be accompanied by several adverse effects. We present the case of a 51-year-old woman who was treated with high-dose CS for a relapse of her multiple sclerosis. Read More

    Smarter Sole Survival.
    J Diabetes Sci Technol 2017 Jan 1:1932296816689105. Epub 2017 Jan 1.
    1 Southern Arizona Limb Salvage Alliance (SALSA), Department of Surgery, University of Arizona, Tucson, AZ, USA.
    Objective: This study examined adherence to alert-based cues for plantar pressure offloading in patients with diabetic foot disease.

    Method And Design: Participants (n = 17) with in diabetic foot remission (history of neuropathic ulceration) were instructed to wear a smart insole system (the SurroSense Rx, Orpyx Medical Technologies Inc, Calgary, Canada) over a three-month period. This device is designed to cue offloading to manage unprotected sustained plantar pressures in an effort to prevent foot ulceration. Read More

    Real-Time Smart Textile-Based System to Monitor Pressure Offloading of Diabetic Foot Ulcers.
    J Diabetes Sci Technol 2017 Feb 1:1932296817695339. Epub 2017 Feb 1.
    3 South Arizona Limb Salvage Alliance (SALSA), University of Arizona College of Medicine, Tucson, AZ, USA.
    Background: The lifetime risk of developing a diabetic foot ulcer (DFU) is at least 25%. A DFU carries a 50% risk for infection and at least 20% of those receive some form of amputation. The most significant parameter that prevents or delays ulcer healing is high plantar pressure. Read More

    Frequency of Cutaneous Fungal Infections and Azole Resistance of the Isolates in Patients with Diabetes Mellitus.
    Adv Biomed Res 2017 6;6:71. Epub 2017 Jun 6.
    Department of Mycology and Parasitology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Diabetic patients are more susceptible to cutaneous fungal infections. The higher blood sugar levels cause increasing the cutaneous fungal infections in these patients. The main objective of this study was to find the frequency of fungal infections among cutaneous lesions of diabetic patients and to investigate azole antifungal agent susceptibility of the isolates. Read More

    Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation.
    Stem Cell Res Ther 2017 Jun 15;8(1):145. Epub 2017 Jun 15.
    Stempeutics Research Private Limited, Akshay Tech Park, # 72&73, 2nd Floor, EPIP Zone, Phase 1, Whitefield, Bangalore, 560066, India.
    Adipose/fat tissue provides an abundant source of stromal vascular fraction (SVF) cells for immediate administration and can also give rise to a substantial number of cultured, multipotent adipose-derived stromal cells (ADSCs). Recently, both SVF and ADSCs have gained wide-ranging translational significance in regenerative medicine. Initially used for cosmetic breast enhancement, this mode of treatment has found use in many diseases involving immune disorders, tissue degeneration, and ischaemic conditions. Read More

    Risk factors associated with poor outcome in diabetic foot ulcer patients.
    Turk J Med Sci 2017 Jun 12;47(3):826-831. Epub 2017 Jun 12.
    Department of Surgery, Madinah Teaching Hospital, Faisalabad, Punjab, Pakistan.
    Background/aim: Diabetic foot ulcers and related complications are a major cause of morbidity and hospital admissions. Our aim was to evaluate the risk factors associated with poor outcome in diabetic foot ulcers.

    Materials And Methods: A prospective study was conducted on patients with diabetic foot ulceration attending the Madinah Teaching Hospital from June 2014 to December 2015. Read More

    Nurses' knowledge on diabetic foot ulcer disease and their attitudes towards patients affected: a cross-sectional institution based study.
    J Clin Nurs 2017 Jun 15. Epub 2017 Jun 15.
    Department of Physiology, Faculty of Medicine, University of Colombo, Sri Lanka.
    Aims And Objectives: To assess nurses' knowledge on diabetic ulcer disease and their attitudes towards patients suffering from it and to identify factors which influence them.

    Background: Diabetic wound care is an evolving specialty with the rising prevalence of diabetes foot complications. As nurses play a key role in wound care, their knowledge and attitudes are important in providing optimum care to patients. Read More

    Hyperbaric Oxygen Therapy: Side Effects Defined and Quantified.
    Adv Wound Care (New Rochelle) 2017 Jun;6(6):210-224
    Division of Hyperbaric Medicine and Wound Care, Department of Emergency Medicine, SUNY Upstate Medical University, Syracuse, New York.
    Significance: Hyperbaric oxygen therapy (HBOT) is an important advanced therapy in the treatment of problem wounds, including diabetic foot ulcers and late effect radiation injury. HBOT remains among the safest therapies used today. Nonetheless, there are side effects associated with HBOT. Read More

    Diabetic Foot Ulcers and Their Recurrence.
    N Engl J Med 2017 06;376(24):2367-2375
    From the Southern Arizona Limb Salvage Alliance (SALSA), Department of Surgery, University of Arizona College of Medicine, Tucson (D.G.A.); Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, United Kingdom (D.G.A., A.J.M.B.); and the Department of Rehabilitation Medicine, Academic Medical Center, University of Amsterdam, and Amsterdam Movement Sciences - both in Amsterdam (S.A.B.).

    Topical antimicrobial agents for treating foot ulcers in people with diabetes.
    Cochrane Database Syst Rev 2017 Jun 14;6:CD011038. Epub 2017 Jun 14.
    Division of Nursing, Midwifery & Social Work, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK, M13 9PL.
    Background: People with diabetes are at high risk for developing foot ulcers, which often become infected. These wounds, especially when infected, cause substantial morbidity. Wound treatments should aim to alleviate symptoms, promote healing, and avoid adverse outcomes, especially lower extremity amputation. Read More

    Using image J to document healing in ulcers of the foot in diabetes.
    Int Wound J 2017 Jun 13. Epub 2017 Jun 13.
    Division of Rehabilitation and Ageing, Queens Medical Centre, University of Nottingham, Nottingham, UK.
    The aim of the study was to assess the reliability of measuring the cross-sectional area of diabetic foot ulcers using Image J software. The inter- and intra-rater reliability of ulcer area measures were assessed using digital images of acetate tracings of ulcers of the foot affecting 31 participants in an off-loading randomised trial. Observations were made independently by five specialist podiatrists, one of whom was experienced in the use of Image J software and educated the other four in a single session. Read More

    Patient Impressions of Possible Catastrophic Outcomes after Diabetic Foot Ulceration.
    Curr Diabetes Rev 2017 Jun 12. Epub 2017 Jun 12.
    School of Medicine, University of Texas Medical Branch, Galveston, Texas. United States.
    Background: Diabetes mellitus (DM) and its complications are well studied; patients with diabetes may suffer from neuropathy and vascular issues, and associated with these, lower extremity ulceration. Ulcers are often refractory to treatment, and can be difficult for both patients and clinicians to manage. Such complications may lead to amputations, which in turn are a risk factor for death. Read More

    Relationship between hyperbaric oxygen therapy and quality of life in participants with chronic diabetic foot ulcers: data from a randomized controlled trial.
    Acta Diabetol 2017 Jun 12. Epub 2017 Jun 12.
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
    Aims: To investigate the effect of hyperbaric oxygen therapy on health-related quality of life (HRQoL) in participants with diabetes and chronic foot ulcers.

    Methods: Using data from a randomized controlled trial, we included 103 participants (49 in hyperbaric oxygen therapy group and 54 in sham group) for analyses. The primary outcome was HRQoL as measured by the EQ-5D-3L instrument, while secondary outcomes included quality of life evaluated by the Short Form 36 (SF-36) and Diabetic Foot Ulcers Scale-Short Form (DFS-SF). Read More

    Depth and combined infection is important predictor of lower extremity amputations in hospitalized diabetic foot ulcer patients.
    Korean J Intern Med 2017 Jun 7. Epub 2017 Jun 7.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, St. Paul's Hospital, The Catholic University of Korea, Seoul, Korea.
    Background/aims: As the prevalence of diabetes mellitus and its complications increase rapidly, diabetic foot ulcers (DFUs), which are a major diabetic complication, are expected to increase. For prevention and effective treatment, it is important to understand the clinical course of DFUs. The aim of this study was to investigate the natural course and predictors of amputation in patients with DFUs who required hospitalization. Read More

    The impact of the multidisciplinary team in the management of individuals with diabetic foot ulcers: a systematic review.
    J Wound Care 2017 Jun;26(6):324-339
    Dip First Line Management, RGN, Professor and Head of the School of Nursing and Midwifery, Royal College of Surgeons in Ireland, Dublin, Ireland.
    Objective: To assess the impact of the multidisciplinary team in the management of the diabetic foot compared with those who did not receive multidisciplinary care.

    Method: A systematic review of the literature was conducted using the following databases: Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medline, Embase and Cochrane Library. The following search terms were used: diabetic foot, multidisciplinary team, patient care team, multidisciplinary care team. Read More

    Peripheral Vascular Disease in Patients with Diabetic Foot Ulcers - An Emerging Trend: A Prospective Study from North India.
    J Assoc Physicians India 2017 May;65(5):14-17
    Assistant Professor, Department of Community Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab.
    Background: Diabetic foot ulcer is one of the chronic complications of diabetes mellitus (DM) with 25% of patients with diabetes developing a foot ulcer during their lifetime leading to amputation. Diabetic foot is classified into 2 main types: neuropathic ulcers (NPU) and neuro-ischemic ulcer (NIU) where in addition to neuropathy peripheral vascular disease (PVD) is also present.

    Aims: We aimed to a) assess the prevalence of Peripheral vascular disease (PVD) in patients of type 2 diabetes mellitus (T2DM) presenting with New Diabetic Foot ulcers (DFU). Read More

    Failure rates of artificial dermis products in treatment of diabetic foot ulcer: A systematic review and network meta-analysis.
    Wound Repair Regen 2017 Jun 8. Epub 2017 Jun 8.
    Department of Reconstructive and Plastic Surgery, Montpellier, France.
    Diabetic foot ulcer (DFU) is a frequent complication in diabetic patients, occurring in up to 25% of those affected. Among the treatments available to clinicians, the use of bioengineered skin substitutes is an attractive alternative. Artificial dermis functions as a matrix, covering the wound and supporting healing and reconstruction of the lost tissue. Read More

    Adipose-derived stem cells seeded in Pluronic F-127 hydrogel promotes diabetic wound healing.
    J Surg Res 2017 May 5. Epub 2017 May 5.
    Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China. Electronic address:
    Background: Chronic nonhealing wound is a multifactorial complication of diabetes that results specifically as a consequence of impaired angiogenesis and currently lacks in effective treatments. Although a stem cell-based therapy may provide a novel treatment to augment diabetic wound healing, inferior cell survival at the diabetic skin wound is one of the key causes that are responsible for the low efficacy of the stem cell therapy.

    Materials And Methods: In this work, we used an injectable, biocompatible, and thermosensitive hydrogel Pluronic F-127 to encapsulate allogeneic nondiabetic adipose-derived stem cells (ADSCs) and topically applied the cells to a full-thickness cutaneous wound in the streptozotocin-induced diabetic model in rats. Read More

    Silver-containing foam dressings with Safetac: a review of the scientific and clinical data.
    J Wound Care 2017 Jun;26(Sup6a):S1-S32
    Kristina Hamberg has over 10 years of experience of working with the design and development of wound care products, particularly those with antimicrobial properties. During that time, she has become an expert within the areas of microbiology and test method development, as well as infection prevention. Kristina was awarded her MSc in food science in 1997 from the University of Kalmar, Sweden, and in 2002 she was awarded a PhD for microbiological evaluation of novel technologies for food preservation by Chalmers Technical University, Gothenburg, Sweden.
    Background Topical antimicrobials, such as silver dressings, are progressively being used alongside systemic antibiotics to provide adjunctive, antimicrobial therapy to wounds that are clinically infected or at risk of infection. To help improve wound management, dressings that use Safetac soft silicone technology in combination with a silver-impregnated foam dressing material were developed by Mölnlycke Health Care (Gothenburg, Sweden). The range comprises Mepilex Ag, Mepilex Border Ag and Mepilex Transfer Ag. Read More

    The application of wireless near infrared spectroscopy on detecting peripheral circulation in patients with diabetes foot ulcer when doing Buerger's exercise.
    Lasers Surg Med 2017 Jun 5. Epub 2017 Jun 5.
    Department of Plastic Surgery, Chiayi Chang Gung Memorial Hospital, Wound Care Center, Chiayi County 613, Taiwan.
    Background And Objectives: The majority of patients with diabetes foot ulcer have peripheral arterial disease. The technique of near infrared spectroscopy (NIRS) used to monitor the dorsal foot blood circulation condition is by measuring the absorption differences between oxy-hemoglobin and deoxy-hemoglobin.

    Study Designs/materials And Methods: Patients with diabetic foot ulcer (DFU) treated in our wound care center were divided into two sub-groups based on the Duplex ultrasound or angiography. Read More

    Development and validation of health related quality of life questionnaire (Indian scenario) in diabetic foot ulcer patients.
    Diabetes Metab Syndr 2017 May 25. Epub 2017 May 25.
    Department of Medicine, Yenepoya University, Mangalore, India. Electronic address:
    Aim: To develop and validate Health Related Quality of Life Questionnaire in Diabetic Foot Ulcer Patients (HRQLQDFU) for Indian scenario.

    Materials And Methods: This study was conducted in two phases. First phase was Development of HRQLQDFU which included literature search and expert interview. Read More

    Management of the Chronic Burn Wound.
    Clin Plast Surg 2017 Jul 2;44(3):679-687. Epub 2017 May 2.
    Division of Plastic and Reconstructive Surgery, Department of Surgery, University of North Carolina Medical Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:
    This article reviews the current evidence in using hyperbaric oxygen therapy (HBOT) in burn wounds. There is also separate consideration of diabetic foot burns and a protocol for use of HBOT in a specific case. The challenges of using HBOT in an acute burn care setting are reviewed. Read More

    Isolation of bacteria from diabetic foot ulcers with special reference to anaerobe isolation by simple two-step combustion technique in candle jar.
    Indian J Med Res 2017 Jan;145(1):97-101
    Department of Microbiology, Institute of Post Graduate Medical Education & Research, Kolkata, India.
    Background & Objectives: Although polymicrobial infections involving both aerobic and anaerobic bacteria are very common in diabetic foot ulcers, in many centres of developing countries, anaerobes are rarely isolated due to technical difficulties. This can be overcome by using a new simple, innovative technique of a combination of candle combustion and use of acidified copper-coated steel wool, as reported here.

    Methods: In-house developed method was used in a prospective clinico-microbiological study for anaerobes from randomly selected 43 patients with diabetic foot ulcers along with conventional method of anaerobic culture in GasPak system and aerobic culture by standard laboratory procedures. Read More

    Hyperbaric Oxygen Therapy for the Treatment of Diabetic Foot Ulcers: A Health Technology Assessment.
    • Authors:
    Ont Health Technol Assess Ser 2017 12;17(5):1-142. Epub 2017 May 12.
    Background: About 15% to 25% of people with diabetes will develop a foot ulcer. These wounds are often resistant to healing; therefore, people with diabetes experience lower limb amputation at about 20 times the rate of people without diabetes. If an ulcer does not heal with standard wound care, other therapeutic interventions are offered, one of which is hyperbaric oxygen therapy (HBOT). Read More

    The Comparative Effectiveness of a Human Fibroblast Dermal Substitute versus a Dehydrated Human Amnion/Chorion Membrane Allograft for the Treatment of Diabetic Foot Ulcers in a Real-world Setting.
    Wounds 2017 May;29(5):125-132
    Background: Impaired wound healing is associated with serious complications in patients with diabetes. Diabetic foot ulcers (DFUs) can lead to costly complications and an increased mortality rate. Standard treatments for DFUs often need to be augmented with adjunctive therapies designed to stimulate healing in recalcitrant wounds. Read More

    Comparative Clinical Study of the Wound Healing Effects of a Novel Micropore Particle Technology: Effects on Wounds, Venous Leg Ulcers, and Diabetic Foot Ulcers.
    Wounds 2017 May 25. Epub 2017 May 25.
    Willingsford Ltd, Southampton, Hampshire, United Kingdom.
    Objective: The purpose of this study was to determine the wound healing effects of Acapsil, a white, odorless powder based on micropore particle technology (MPPT) (Willingsford Ltd, Southampton, UK) by comparing it to Gentaxane (Gentaksan, Borshchagovsky CCP, Kyiv, Ukraine) (polydimethylsiloxane powder with gentamicin antibiotic) and Ioddicerin (Farmak, Kyiv, Ukraine) (iodine with dimethyl sulfoxide [DMSO]).

    Materials And Methods: The study included 266 patients with primarily trophic ulcers caused by pancreatic diabetes and venous insufficiency of the lower extremities, carbuncles, phlegmons, infected third- or fourth-degree heat burns, and infiltrations of postoperative wounds. The products were applied once daily to the wound until it was clean (ie, free from necrosis, pus, and fibrinogenous thickenings). Read More

    Promoting Limb Salvage through Multi-Disciplinary Care of the Diabetic Patient.
    Curr Treat Options Cardiovasc Med 2017 Jul;19(7):55
    Division of Vascular Surgery, Atlanta VA Medical Center, Surgery and Research Services, Emory University, 101 Woodruff Circle Suite 5105, Atlanta, GA, 30322, USA.
    Opinion Statement: Despite an explosion in the number of options available for helping diabetic patients heal wounds, major amputation remains a critical issue for these persons. Since diabetes prematurely ages tissues and no organ system is immune to its presence, it makes inherent sense that multi-disciplinary team approaches to these patients is necessary to make significant strides forward. Here, we present literature from the fields of podiatric surgery/medicine, vascular and plastic surgery and introduce the successes that a multi-disciplinary limb salvage center can have on the lives and limbs of patients with diabetes. Read More

    Primary cutaneous B-cell lymphoma and chronic leg ulcers in a patient with type 2 diabetes.
    Endocrinol Diabetes Metab Case Rep 2017 24;2017. Epub 2017 May 24.
    Division of EndocrinologyDiabetes and Metabolism, Department of Medicine.
    The incidences of type 2 diabetes mellitus and many cancers are rapidly increasing worldwide. Diabetes is a strong risk factor for some cancers (including lymphomas) and is also associated with adverse cancer outcomes. After gastrointestinal tract, the skin is the second most frequent extranodal site involved by non-Hodgkin lymphomas and the cutaneous B-cell lymphomas (CBCLs) range from 25% to 30% of all primary cutaneous lymphomas. Read More

    Quantitative assessment of wound healing using high-frequency ultrasound image analysis.
    Skin Res Technol 2017 May 29. Epub 2017 May 29.
    Department of Orthopaedics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
    Purpose: We aimed to develop a method for quantitative assessment of wound healing in ulcerated diabetic feet.

    Methods: High-frequency ultrasound (HFU) images of 30 wounds were acquired in a controlled environment on post-debridement days 7, 14, 21, and 28. Meaningful features portraying changes in structure and intensity of echoes during healing were extracted from the images, their relevance and discriminatory power being verified by analysis of variance. Read More

    Post-occlusive reactive hyperaemia of skin microvasculature and foot complications in type 2 diabetes.
    J Diabetes Complications 2017 May 14. Epub 2017 May 14.
    School of Health Sciences, University of Newcastle, Australia; Priority Research Centre for Physical activity and Nutrition, University of Newcastle.
    Aims: Diabetes-related microvascular disease has been implicated in the development of foot ulceration and amputation. Assessment of microvascular function may be effective in identifying those at risk of diabetic foot complications. We investigated the relationship between active or previous foot complication and post-occlusive reactive hyperaemia (PORH) measured by laser-Doppler fluxmetry (LDF) in people with type 2 diabetes. Read More

    Incidence and risk factors for developing infection in patients presenting with uninfected diabetic foot ulcers.
    PLoS One 2017 17;12(5):e0177916. Epub 2017 May 17.
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
    Objective: There is a paucity of research on patients presenting with uninfected diabetic foot ulcers (DFU) that go on to develop infection. We aimed to investigate the incidence and risk factors for developing infection in a large regional cohort of patients presenting with uninfected DFUs.

    Methods: We performed a secondary analysis of data collected from a validated prospective state-wide clinical diabetic foot database in Queensland (Australia). Read More

    Hyperbaric oxygen therapy for wound healing in diabetic rats: Varying efficacy after a clinically-based protocol.
    PLoS One 2017 17;12(5):e0177766. Epub 2017 May 17.
    Department of Plastic and Reconstructive Surgery, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.
    Hyperbaric oxygen therapy (HBOT) is a clinical treatment in which a patient breathes pure oxygen for a limited period of time at an increased pressure. Although this therapy has been used for decades to assist wound healing, its efficacy for many conditions is unproven and its mechanism of action is not yet fully clarified. This study investigated the effects of HBOT on wound healing using a diabetes-impaired pressure ulcer rat model. Read More

    A randomized clinical trial of a human acellular dermal matrix demonstrated superior healing rates for chronic diabetic foot ulcers over conventional care and an active acellular dermal matrix comparator.
    Wound Repair Regen 2017 May 24. Epub 2017 May 24.
    LifeNet Health, Virginia Beach, Virginia.
    This study compared the efficacy and safety of a human acellular dermal matrix (ADM), D-ADM, with a conventional care arm and an active comparator human ADM arm, GJ-ADM, for the treatment of chronic diabetic foot ulcers. The study design was a prospective, randomized controlled trial that enrolled 168 diabetic foot ulcer subjects in 13 centers across 9 states. Subjects in the ADM arms received one application but could receive one additional application of ADM if deemed necessary. Read More

    Magnesium Supplementation and the Effects on Wound Healing and Metabolic Status in Patients with Diabetic Foot Ulcer: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Biol Trace Elem Res 2017 May 24. Epub 2017 May 24.
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR, Iran.
    Hypomagnesemia is associated with the development of neuropathy and abnormal platelet activity, both of which are risk factors for diabetic foot ulcer (DFU). This study was carried out to evaluate the effects of magnesium administration on wound healing and metabolic status in subjects with DFU. This randomized, double-blind, placebo-controlled trial was performed among 70 subjects with grade 3 DFU. Read More

    [Efficacy of two bariatric surgeries in type 2 diabetic patients with a body mass index of 25-27.5].
    Nan Fang Yi Ke Da Xue Xue Bao 2017 May;37(5):693-697
    Southern Medical University, Guangzhou 510515, China.E-mail:
    Objective: To evaluate the therapeutic effects of laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic duodenal-jejunal bypass with sleeve gastrectomy (SADJB-SG) in patients with type 2 diabetes mellitus and a low body mass index (BMI) of 25-27.5.

    Methods: Thirty-one type 2 diabetic patients with a BMI of 25-27. Read More

    Novel biological therapies for the treatment of diabetic foot ulcers.
    Expert Opin Biol Ther 2017 Jun 1:1-9. Epub 2017 Jun 1.
    e Department of Anatomy, College of Medicine & Health Sciences , United Arab Emirates University , Al Ain , United Arab Emirates.
    Introduction: The number of people with diabetes mellitus (DM) is estimated to exceed 640 million by the year 2040. Diabetic foot ulcer (DFU) is a debilitating illness that affects more than 2% of DM patients. DFU is caused by DM-induced neural and vascular lesions leading to a reduced sensation and microcirculation. Read More

    Histomorphological observation of surgical debridement combined with negative pressure therapy in treatment of diabetic foot.
    Chin J Traumatol 2017 Apr 20. Epub 2017 Apr 20.
    Institute of Burn, Ruijin Hospital, Medical School, Shanghai Jiaotong University, Shanghai 20025, China.
    Purpose: To further study the mechanism of epithelization on the fascia side of the flap after surgical incision and the treatment of the negative pressure therapy.

    Methods: With the patients' informed consent, parts of tissue samples were obtained from a 51-year-old diabetic patient who was suffering lower extremity ulcers. The samples were processed with hematoxylin and eosin (HE) staining and Masson trichrome staining. Read More

    The effect of a common antibiotics doxycycline on non-healing chronic wound.
    Curr Pharm Biotechnol 2017 May 18. Epub 2017 May 18.
    Department of Microbiology, Immunology & Pathology, Des Moines University College of Osteopathic Medicine, Des Moines, Iowa, 50312. Colombia.
    Up to 25% of diabetic patients will develop a diabetic foot ulcer. Chronic wounds such as diabetic foot ulcers often fail to heal with conventional therapies. In recent years, it has been identified that chronic wounds are usually associated with elevated level of matrix metalloproteinases (MMPs). Read More

    Potential Biomolecules and Current Treatment Technologies for Diabetic Foot Ulcer: an Overview.
    Curr Diabetes Rev 2017 May 18. Epub 2017 May 18.
    Department of Biotechnology, University of Madras, Chennai. India.
    Background: Diabetic foot ulceration remains a major challenge is one of the most expensive and a leading cause of major and minor among patients with a diabetic foot ulcer. Hence the purpose of this review emphases on potential molecular markers involved in diabetic ulcer physiology, the efficacy of different types of dressing materials, therapy and newer therapeutic approach like nanoparticles for the of diabetic foot ulcer.

    Methods: We conducted a systematic literature reviews search by using Pubmed and other web search. Read More

    A case series of verrucae vulgares mimicking hyperkeratosis in individuals with diabetic foot ulcers.
    Diabet Med 2017 May 19. Epub 2017 May 19.
    Diabetes Division, Department of Medicine I, St. Josef-Hospital, Ruhr-University Bochum.
    Background: Diabetic foot ulcers are a common complication in the advanced stages of diabetes mellitus. Certain lesions may be refractory to usual treatments with prolonged healing. In these cases, differential diagnoses to classical ulcers should be considered. Read More

    Impact of lysyl oxidase (G473A) polymorphism on diabetic foot ulcers.
    Int J Biol Macromol 2017 May 15;103:242-247. Epub 2017 May 15.
    Vascular Biology Lab, AU-KBC Research Centre, Anna University, Chennai, India; Department of Biotechnology, Anna University, Chennai, India. Electronic address:
    Lysyl oxidase (LOX) is an extra-cellular matrix-modifying enzyme that has been linked to cell proliferation, metastasis, angiogenesis and wound healing. This study was designed to examine the association of LOX gene polymorphism G473A, G>A, (rs1800449) located in exon 1 of the LOX gene in diabetic subjects with and without diabetic foot ulcers (DFU) and its impact of expression on DFU. Genotypic analysis of 906 samples showed a significant increase in the presence of 'A' allele in type 2 diabetes mellitus (T2DM) and DFU when compared to that of control subjects. Read More

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