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    Recent advances in biomaterials for the treatment of diabetic foot ulcers.
    Biomater Sci 2017 Aug 22. Epub 2017 Aug 22.
    Department of Chemical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, USA. and Department of Biomedical Engineering, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA 15213, USA.
    Diabetes mellitus is one of the most challenging epidemics facing the world today, with over 300 million patients affected worldwide. A significant complication associated with diabetes is hyperglycemia, which impairs wound healing. The rise in the diabetic patient population in recent years has precipitated an increase in the incidence and prevalence of chronic diabetic wounds, most commonly the diabetic foot ulcer. Read More

    Sarcopenia is independently associated with diabetic foot disease.
    Sci Rep 2017 Aug 21;7(1):8372. Epub 2017 Aug 21.
    Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, China.
    The aim of this study was to investigate the association of sarcopenia and diabetic foot disease (DFD) in a cross-sectional study. Body composition was assessed using dual-energy X-ray-absorptiometry (DXA) among 1105 patients with type 2 diabetes (120 patients with newly diagnosed DFD [DFD duration less than 3 months]). Severity of DFD was assessed, referring to foot ulcers, Wagner grade and the percentage of amputation. Read More

    Topical propolis improves wound healing in patients with diabetic foot ulcer: a randomized controlled trial.
    Nat Prod Res 2017 Aug 22:1-4. Epub 2017 Aug 22.
    h Biotechnology Research Center , Mashhad University of Medical Sciences , Mashhad , Iran.
    In this randomized controlled trial, diabetic patients with foot ulcers (Wagner grades 1 and 2) were randomly assigned to conventional therapies for diabetic foot ulcer plus topical propolis ointment (5%; twice daily) or conventional therapies alone. The process of ulcer healing was observed during 4 weeks and compared between the two groups regarding the size, erythema, exudates, white blood cell (WBC) count and erythrocyte sedimentation rate (ESR). The process of ulcer size reduction during the four-week period of study was significantly different between the groups. Read More

    Multimodal optical measurement for study of lower limb tissue viability in patients with diabetes mellitus.
    J Biomed Opt 2017 Aug;22(8):1-10
    Aston University, Aston Institute of Photonic Technologies, Optoelectronics and Biomedical Photonics, United Kingdom.
    According to the International Diabetes Federation, the challenge of early stage diagnosis and treatment effectiveness monitoring in diabetes is currently one of the highest priorities in modern healthcare. The potential of combined measurements of skin fluorescence and blood perfusion by the laser Doppler flowmetry method in diagnostics of low limb diabetes complications was evaluated. Using Monte Carlo probabilistic modeling, the diagnostic volume and depth of the diagnosis were evaluated. Read More

    Patients With Diabetic Foot Disease Fear Major Lower-Extremity Amputation More Than Death.
    Foot Ankle Spec 2017 Feb 1:1938640017694722. Epub 2017 Feb 1.
    Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas (DKW).
    Background: The aim of this study was to identify the most-feared complications of diabetes mellitus (DM), comparing those with diabetic foot pathology with those without diabetic foot pathology.

    Methods: We determined the frequency of patients ranking major lower-extremity amputation (LEA) as their greatest fear in comparison to blindness, death, diabetic foot infection (DFI), or end-stage renal disease (ESRD) requiring dialysis. We further categorized the study group patients (N = 207) by their pathology such as diabetic foot ulcer (DFU), Charcot neuroarthropathy, foot infection, or acute neuropathic fractures and dislocations. Read More

    Dysregulation of Wound Healing Mechanisms in Diabetes and the Importance of Negative Pressure Wound Therapy (NPWT).
    Diabetes Metab Res Rev 2017 Aug 17. Epub 2017 Aug 17.
    Internal Medicine D, Diabetes & Metabolism, Rambam Health Care Campus and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
    Diabetes is a serious disease with severe side effects and comorbidities. Diabetic foot with its chronic non-healing ulcers, or diabetic food ulcers (DFU) as they are commonly called, can be devastating, even leading to amputation. Many therapies exist to assist and improve wound healing. Read More

    History, prevalence and assessment of limited joint mobility: from stiff hand syndrome to diabetic foot ulcer prevention.
    Curr Diabetes Rev 2017 Aug 16. Epub 2017 Aug 16.
    Department of Experimental and Clinical Medicine, University of Florence, Florence. Italy.
    Introduction: Diabetes mellitus (DM) is one of the most important global public health problems. Patients with DM may develop different dreaded complications during their lifetime, one of which is limited joint mobility (LJM). Joint abnormalities and LJM are problems that can arise at disease onset, and progressively worsen together with the disease. Read More

    Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model.
    J Vis Exp 2017 Aug 4(126). Epub 2017 Aug 4.
    Diabetic Center, Tokyo Women's Medical University School of Medicine.
    Artificial skin has achieved considerable therapeutic results in clinical practice. However, artificial skin treatments for wounds in diabetic patients with impeded blood flow or with large wounds might be prolonged. Cell-based therapies have appeared as a new technique for the treatment of diabetic ulcers, and cell-sheet engineering has improved the efficacy of cell transplantation. Read More

    MicroRNA-132 with therapeutic potential in chronic wounds.
    J Invest Dermatol 2017 Aug 11. Epub 2017 Aug 11.
    Unit of Dermatology and Venereology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address:
    Chronic wounds represent a major and rising health and economic burden worldwide. There is a continued search towards more effective wound therapy. We found significantly reduced microRNA-132 (miR-132) expression in human diabetic ulcers compared to normal skin wounds, and also in skin wounds of leptin receptor-deficient (db/db) diabetic mice compared to wild-type mice. Read More

    An innovative sealed shoe to off-load and heal diabetic forefoot ulcers - a feasibility study.
    Diabet Foot Ankle 2017 25;8(1):1348178. Epub 2017 Jul 25.
    Department of Orthopaedics, Institute of Clinical Sciences, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
    Background: Non-removable knee-high devices are the gold standard to treat diabetic foot ulcers located on the plantar forefoot, but they immobilize the ankle, which restricts daily life activities and has negative effects on joint functioning. Objective: To investigate the feasibility of sealing a therapeutic shoe to off-load and heal diabetic forefoot ulcers. Design: A case series of seven men with type 2 diabetes and a metatarsal head ulcer were prescribed therapeutic shoes and custom-made insoles. Read More

    In-hospital costs of diabetic foot disease treated by a multidisciplinary foot team.
    Diabetes Res Clin Pract 2017 Jul 29;132:68-78. Epub 2017 Jul 29.
    Department of Plastic-, Reconstructive- and Hand Surgery, Franciscus Gasthuis & Vlietland, Rotterdam, The Netherlands; Department of Plastic-, Reconstructive- and Hand Surgery, Utrecht University Medical Center, Utrecht, The Netherlands.
    Background: The diabetic foot imposes significant burden on healthcare systems. Obtaining knowledge on the extent of the costs of diabetic foot ulcers (DFUs) is of value to health care researchers investigating cost-effectiveness of interventions that prevent these costly complications.

    Objectives: To estimate the in-hospital costs associated with the treatment of DFUs by a multidisciplinary diabetic foot team. Read More

    Comparison of lower limb muscle strength between diabetic neuropathic and healthy subjects using OpenSim.
    Gait Posture 2017 Jul 31;58:194-200. Epub 2017 Jul 31.
    Department of Information Engineering, University of Padova, Via Gradenigo 6b I, 35131 Padova, Italy. Electronic address:
    Diabetes neuropathy and vasculopathy are the two major complications of diabetes mellitus, leading to diabetic foot disease, of which the worst consequences are plantar ulcers and amputations. Motor impairments like joint stiffness and loss of balance are distinctive effects of diabetes and they have been extensively explored. However, while altered muscle function has been also assessed through experimentally measured surface electromyography, little is known about muscle forces. Read More

    Inflammatory markers as risk factors for infection with multidrug-resistant microbes in diabetic foot subjects.
    Foot (Edinb) 2017 May 3;32:44-48. Epub 2017 May 3.
    Rajiv Gandhi Centre for Diabetes and Endocrinology, J.N. Medical College, Aligarh Muslim University, Aligarh, India; Department of Medicine, J.N. Medical College, Aligarh Muslim University, Aligarh, India; Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, India. Electronic address:
    Background: Diabetic foot ulcers (DFUs), a dreadful microvascular complication of diabetes is responsible for substantial increase in morbidity and mortality. Infection, not a cause, but a consequence in DFUs that accounts for minor or major limb loss. The current study aimed to evaluate the microbial etiology of infected diabetic foot ulcers in northern tertiary care hospital, assessment of risk factors and role of inflammatory markers involved in colonization of multidrug-resistant organisms (MDROs) and their impact on the outcome. Read More

    Point-of-care fluorescence imaging predicts the presence of pathogenic bacteria in wounds: a clinical study.
    J Wound Care 2017 Aug;26(8):452-460
    Judy Dan Research and Treatment Centre, Ontario Wound Care Inc., North York, ON, Canada.
    Objective: Bacteria in chronic wounds are invisible to the naked eye and can lead to delayed wound healing. Point-of-care bacterial fluorescence imaging illuminates a wound with 405nm light, triggering bacteria to produce red fluorescence and enabling real-time bacterial localisation. Prospective, single-blind clinical trials (clinicaltrials. Read More

    Prevalence of Diabetic Foot Ulcer and Associated Factors among Adult Diabetic Patients Who Attend the Diabetic Follow-Up Clinic at the University of Gondar Referral Hospital, North West Ethiopia, 2016: Institutional-Based Cross-Sectional Study.
    J Diabetes Res 2017 16;2017:2879249. Epub 2017 Jul 16.
    College of Medicine and Health Science, Department of Midwifery, University of Gondar, P.O. Box 196, Gondar, Ethiopia.
    Diabetes mellitus is a metabolic disorder which is characterized by multiple long-term complications that affect almost every system in the body. Foot ulcers are one of the main complications of diabetes mellitus. However, there is limited evidence on the occurrence of foot ulcer and influencing factors in Ethiopia. Read More

    Lichenoid esophagitis presenting as fatal upper gastrointestinal bleeding in a 52 year-old woman: a case diagnosed by autopsy.
    BMC Gastroenterol 2017 Aug 8;17(1):95. Epub 2017 Aug 8.
    Department of Anatomical Pathology and Cytology, Maisonneuve-Rosemont Hospital, 5415 Boulevard de L'Assomption, Montreal, Quebec, H1T 2M4, Canada.
    Background: "Lichenoid esophagitis" is a descriptive term for a lichenoid pattern of inflammation in the esophagus for which a precise histologic diagnosis cannot be established. The differential diagnosis includes lichen planus, a drug-related reaction, and viral infection. Lichenoid esophagitis causing death has not been reported previously. Read More

    CXCR4 antagonist delivery on decellularized skin scaffold facilitates impaired wound healing in diabetic mice by increasing expression of SDF-1 and enhancing migration of CXCR4-positive cells.
    Wound Repair Regen 2017 Jun 8. Epub 2017 Jun 8.
    College of Biophotonics, South China Normal University, Guangzhou, China.
    C-X-C chemokine receptor type 4 (CXCR4) is an alpha-chemokine receptor specific for stromal cell-derived factor 1 (SDF-1 also called CXCL12). The antagonist of CXCR4 can mobilize CD34+ cells and hematopoietic stem cells from bone marrow within several hours, and it has an efficacy on diabetes ulcer through acting on the SDF-1/CXCR4 axis. In this study, we investigated for the first time whether the antagonist of CXCR4 (Plerixafor/AMD3100) delivered on acellular dermal matrix (ADM) may accelerate diabetes-impaired wound healing. Read More

    A Study of Thermistor Performance within a Textile Structure.
    Sensors (Basel) 2017 Aug 5;17(8). Epub 2017 Aug 5.
    School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK.
    Textiles provide an ideal structure for embedding sensors for medical devices. Skin temperature measurement is one area in which a sensor textile could be particularly beneficial; pathological skin is normally very sensitive, making the comfort of anything placed on that skin paramount. Skin temperature is an important parameter to measure for a number of medical applications, including for the early detection of diabetic foot ulcer formation. Read More

    Can amputation be prevented in diabetic foot? Interdisciplinary approach to diabetic foot: a case report.
    Undersea Hyperb Med 2017 Mar-Apr;44(2):157-160
    Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey.
    Diabetic foot ulcers may result in loss of an extremity and may even lead to mortality. The use of comprehensive foot care programs which include early screening and evaluation of problems, foot care education, preventive therapy and referral to specialists has been shown to reduce amputation rates by 49-85 [percent]. A 51-year-old woman with Type 2 diabetes under surveillance for nine months was referred from the emergency department. Read More

    Venous Ulcers Treated With a Hyaluronic Acid Extracellular Matrix and Compression Therapy: Interim Analysis of a Randomized Controlled Trial.
    Wounds 2017 Jul;29(7):E51-E54
    University Wound Care Center, Center for Vascular Health, Bronx, NY.
    Diabetic foot ulcers (DFUs) are a severe and costly complication of diabetes and may result in foot amputation.

    Case Report: A 69-year-old man with a 10-year history of type 2 diabetes, who was undergoing routine care for diabetes in the authors' clinic, developed a DFU of his right foot of 4 years' duration. The wound did not respond to conventional treatments, and imaging studies were normal. Read More

    Squamous Cell Carcinoma Arising in a Chronic, Nonhealing Diabetic Foot Ulcer.
    Wounds 2017 Jul;29(7):E48-E50
    Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences.
    Diabetic foot ulcers (DFUs) are a severe and costly complication of diabetes and may result in foot amputation.

    Case Report: A 69-year-old man with a 10-year history of type 2 diabetes, who was undergoing routine care for diabetes in the authors' clinic, developed a DFU of his right foot of 4 years' duration. The wound did not respond to conventional treatments, and imaging studies were normal. Read More

    Mini-encyclopaedia of the wound healing - Opportunities for integrating multi-omic approaches into medical practice.
    J Proteomics 2017 Jul 28. Epub 2017 Jul 28.
    Radiological Clinic, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany; Breast Cancer Research Centre, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany; Centre for Integrated Oncology, Cologne-Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany. Electronic address:
    Wound healing is a highly complex life-important repair process triggered by plenty of local and/or systemic organ and tissue damaging events, such as an acute surgical invasion, accidental organ and tissue damages, acute and chronic diseases, aggressive local and systemic therapeutic approaches (e.g. irradiation and systemic chemotherapy). Read More

    NOS1AP genetic variation is associated with impaired healing of diabetic foot ulcers and diminished response to healing of circulating stem/progenitor cells.
    Wound Repair Regen 2017 Jul 29. Epub 2017 Jul 29.
    Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
    It is unclear why many with diabetes develop foot ulcers (DFU) and why some do not heal. It could be associated with genetic variation. We have previously shown that NOS1AP variation is associated with lower extremity amputation in those with diabetes and that circulating stem progenitor cell concentration (SPC) is associated with impaired foot ulcer healing in those with diabetes. Read More

    "Visually impaired elderly patient ingests pill desiccant, leading to acute hypoxic respiratory failure requiring intubation".
    BMC Geriatr 2017 Jul 28;17(1):166. Epub 2017 Jul 28.
    Department of Internal Medicine Residency Program, University of New Mexico, 1 University of New Mexico, Albuquerque, NM, 87131-0001, USA.
    Background: A significant percentage of elderly patients suffer from both polypharmacy and visual impairment. This combination can increase the risk of an adverse event related to medication. This case highlights an unusual, but potentially deadly, medication adverse event. Read More

    The Use of Interpreters in Medical Triage during a Refugee Mass-Gathering Incident in Europe.
    Prehosp Disaster Med 2017 Jul 28:1-4. Epub 2017 Jul 28.
    3Anesthesiology Department,Hospital zum Heiligen Geist,Frankfurt am Main,Germany.
    Introduction During a refugees' mass-gathering incident in Kos Island, Greece, Médecins Sans Frontières (MSF; Brussels, Belgium) teams provided emergency medical care. A case report of the event focusing on difficulties encountered by the interpreters during triage and emergency response was prepared.

    Methods: Data collected during the event were reviewed from the patient's register and qualitative interviews were obtained from the MSF interpreters involved in the response. Read More

    A longitudinal study of the diabetic skin and wound microbiome.
    PeerJ 2017 20;5:e3543. Epub 2017 Jul 20.
    The i3 institute, University of Technology Sydney, Sydney, New South Wales, Australia.
    Background: Type II diabetes is a chronic health condition which is associated with skin conditions including chronic foot ulcers and an increased incidence of skin infections. The skin microbiome is thought to play important roles in skin defence and immune functioning. Diabetes affects the skin environment, and this may perturb skin microbiome with possible implications for skin infections and wound healing. Read More

    Potential of circulatory procalcitonin as a biomarker reflecting inflammation among South Indian diabetic foot ulcers.
    J Vasc Surg 2017 Jul 20. Epub 2017 Jul 20.
    SRM Research Institute, SRM University, Chennai, Tamilnadu, India. Electronic address:
    Objective: Diabetic foot ulcer (DFU), the major complication associated with diabetes mellitus, has been shown to precede amputation in up to 90% of cases. Recent data reveal that procalcitonin (PCT) is a valid marker for the diagnosis of bacterial infections compared with traditional markers like white blood cell count, C-reactive protein levels, and erythrocyte sedimentation rate in DFU patients. Furthermore, cytokines are proposed to act as modulators and mediators for the expression and release of PCT into the circulation. Read More

    Levels of wound calprotectin and other inflammatory biomarkers aid in deciding which patients with a diabetic foot ulcer need antibiotic therapy (INDUCE study).
    Diabet Med 2017 Jul 22. Epub 2017 Jul 22.
    Division of Infection and Immunity, Cardiff University, Cardiff, UK.
    Aims: Deciding if a diabetic foot ulcer is infected in a community setting is challenging without validated point-of-care tests. Four inflammatory biomarkers were investigated to develop a composite algorithm for mildly infected diabetic foot ulcers: venous white cell count, C-reactive protein (CRP) and procalcitonin, and a novel wound exudate calprotectin assay. Calprotectin is a marker of neutrophilic inflammation. Read More

    Changes in the extracellular matrix surrounding human chronic wounds revealed by 2-photon imaging.
    Int Wound J 2017 Jul 20. Epub 2017 Jul 20.
    Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
    Chronic wounds are a growing problem worldwide with no effective therapeutic treatments available. Our objective was to understand the composition of the dermal tissue surrounding venous leg ulcers and diabetic foot ulcers (DFU). We used novel 2-photon imaging techniques alongside classical histology to examine biopsies from the edges of two common types of chronic wound, venous leg ulcers and DFU. Read More

    Does Continuous Diffusion of Oxygen Improve Diabetic Foot Ulcer Healing?
    J Diabetes Sci Technol 2017 Jul 1:1932296817717999. Epub 2017 Jul 1.
    1 Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas TX, USA.
    The objective of this article is to evaluate the study design, rational and results of Continuous Diffusion of Oxygen Therapy (CDOT) to heal diabetic foot ulcers (DFUs). The study was a double-blinded placebo controlled randomized clinical study to evaluate DFUs over a 12-week period. The primary outcome was the proportion of ulcers that healed and the secondary outcome that was reported was the time to ulcer healing. Read More

    Leucocyte- and platelet-rich fibrin (L-PRF) as a regenerative medicine strategy for the treatment of refractory leg ulcers: a prospective cohort study.
    Platelets 2017 Jul 20:1-8. Epub 2017 Jul 20.
    b Department of Oral Health Sciences, Katholieke Universiteit Leuven (KUL) & Periodontology , University Hospitals Leuven , Leuven , Belgium.
    Chronic wounds (VLU: venous leg ulcer, DFU: diabetic foot ulcer, PU: pressure ulcer, or complex wounds) affect a significant proportion of the population. Despite appropriate standard wound care, such ulcers unfortunately may remain open for months or even years. The use of leukocyte- and platelet-rich fibrin (L-PRF) to cure skin ulcers is a simple and inexpensive method, widely used in some countries but unknown or neglected in most others. Read More

    Malignant melanoma misdiagnosed as diabetic foot ulcer: A case report.
    Medicine (Baltimore) 2017 Jul;96(29):e7541
    aDepartment of Endocrinology and Metabolism bHealth Management Center cDiabetic Foot Care Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
    Rationale: Acral lentiginous melanoma (AML) does not exhibit the classic signs of malignant melanoma. ALM is frequently misdiagnosed because of its unusual sites and atypical clinical morphologies, which lead to poor prognosis.

    Patient Concerns: A female patient aged 78 years was presented to our center with two ulcers on her right foot. Read More

    Risk factors for amputation in patients with diabetic foot infection: a prospective study.
    Int Wound J 2017 Jul 19. Epub 2017 Jul 19.
    Department of Dermatology, Ege University Medical Faculty, Izmir, Turkey.
    There is a variety of diagnostic and therapeutic algorithms for diabetic foot infections (DFIs). Some of them are too difficult to be applied in routine clinical approach. In the routine clinical approach, it is necessary to find new risk factors and end up with a quick and easy assessment of DFIs. Read More

    Eurycoma longifolia, a potential phytomedicine for the treatment of cancer: Evidence of p53-mediated apoptosis in cancerous cells.
    Curr Drug Targets 2017 Jul 18. Epub 2017 Jul 18.
    Department of Pharmacology, Faculty of Medicine, University Kebangsaan Malaysia (The National University of Malaysia), Jalan Yaacob Latif 56000, Cheras. Malaysia.
    Background: Eurycoma longifolia is a well-documented herbal medicine that has gained widespread recognition due to its versatile pharmacological activities including anticancer, anti-malarial, antimicrobial, antioxidant, aphrodisiac, anti-inflammatory, anxiolytic, anti-diabetic, anti-rheumatism and anti-ulcer. Plethora of in vitro and in vivo studies evidenced their excellent anti-proliferative and anticancer efficacy against various types of human cancers.

    Objective: This review was aimed to critically analyze the therapeutic viability and anticancer efficacy of Eurycoma longifolia in the treatment of cancer and also to propose its molecular and translational mechanism of cytotoxicity against cancerous cells. Read More

    Bacteriology Of Diabetic Foot In Tertiary Care Hospital; Frequency, Antibiotic Susceptibility And Risk Factors.
    J Ayub Med Coll Abbottabad 2017 Apr-Jun;29(2):234-240
    Department of Medicine, Rawal Institute of Health Sciences, Islamabad, Pakistan.
    Background: Diabetic foot being one of the frequent and disabling complications of diabetes. In view of widespread regional variation in causative organisms and antimicrobial susceptibility, the current study aimed to determine frequency of causative organisms, their antimicrobial susceptibility and associated risk factors.

    Methods: This descriptive cross-sectional study was conducted in 6 months' duration at dept. Read More

    Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.
    J Diabetes Complications 2017 Sep 28;31(9):1394-1400. Epub 2017 Jun 28.
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R., Iran. Electronic address:
    Background: Data on the effects of flaxseed oil omega-3 fatty acids supplementation on wound healing and metabolic status in subjects with diabetic foot ulcer (DFU) are scarce.

    Objective: This study was conducted to evaluate the effects of flaxseed oil omega-3 fatty acids supplementation on wound healing and metabolic status in subjects with DFU.

    Methods: The current randomized, double-blind, placebo-controlled trial was conducted among 60 subjects (aged 40-85years old) with grade 3 DFU. Read More

    Quantitative Evaluation of Rehabilitation Effect on Peripheral Circulation of Diabetic Foot.
    IEEE J Biomed Health Inform 2017 Jul 13. Epub 2017 Jul 13.
    Diabetics may encounter different foot problems, which easily lead to infection, ulcers, and increased risk of amputation due to nerve or vascular injury. In order to reduce the risk of amputation, Buerger's exercise is one of the frequently used rehabilitation to improve the blood circulation in the lower limbs. However, it is difficult to evaluate the rehabilitation efficiency of Buerger's exercise objectively. Read More

    The molecular biology in wound healing & non-healing wound.
    Chin J Traumatol 2017 Aug 30;20(4):189-193. Epub 2017 Jun 30.
    Institute of Burn, Ruijin Hospital, Medical School, Shanghai Jiaotong University, Shanghai 20025, China. Electronic address:
    The development of molecular biology and other new biotechnologies helps us to recognize the wound healing and non-healing wound of skin in the past 30 years. This review mainly focuses on the molecular biology of many cytokines (including growth factors) and other molecular factors such as extracellular matrix (ECM) on wound healing. The molecular biology in cell movement such as epidermal cells in wound healing was also discussed. Read More

    Frequency Of Common Bacteria And Their Antibiotic Sensitivity Pattern In Diabetics Presenting With Foot Ulcer.
    J Ayub Med Coll Abbottabad 2016 Jul-Sep;28(3):528-533
    Department of Medicine, Khyber Teaching Hospital, Peshawar, Pakistan.
    Background: Foot ulcers are one of the most important complications of diabetes mellitus and often lead to lower limb amputation. Diabetic foot ulcers are susceptible to infection. The objective of this study was to determine the frequency of common bacteria infecting these ulcers and their antibiotic sensitivity pattern. Read More

    Differences in the daily activity of patients with diabetic foot ulcers compared to controls in their free-living environments.
    Int Wound J 2017 Jul 13. Epub 2017 Jul 13.
    Department of Podiatry, Metro North Hospital & Health Service, Brisbane, Australia.
    The aims of our study were to investigate multiple daily activity outcomes in patients with diabetic foot ulcers (DFU) compared to diabetic peripheral neuropathy (DPN) and diabetes (DM) controls in their free-living environments. We examined daily activity outcomes of 30 patients with DFU, 23 DPN and 20 DM. All patients wore a validated multi-sensor device for > 5 days (>22 hours per day) to measure their daily activity outcomes: steps, energy expenditure (kJ), average metabolic equivalent tasks (METs), physical activity (>3·0 METs) duration and energy expenditure, lying duration, sleep duration and sleep quality. Read More

    Amputation predictors in diabetic foot ulcers treated with hyperbaric oxygen.
    J Wound Care 2017 Jul;26(7):361-366
    Department of Underwater and Hyperbaric Medicine, Faculty of Meram Medicine, Necmettin Erbakan University, Konya, Turkey.
    Objective: Although hyperbaric oxygen therapy (HBOT) has long been used for diabetic foot ulcers (DFUs), its effectiveness is still controversial. The aim of this study was to investigate the efficacy of HBOT in the management of DFUs and identify amputation predictors.

    Method: Patients with chronic DFUs (Wanger grade 2-5) were included in the study, which took place between January 2010 and December 2012. Read More

    Redox Signaling in Diabetic Wound Healing Regulates Extracellular Matrix Deposition.
    Antioxid Redox Signal 2017 Aug 10. Epub 2017 Aug 10.
    1 Department of Pathology, Yale University School of Medicine , New Haven, Connecticut.
    Significance: Impaired wound healing is a major complication of diabetes, and can lead to development of chronic foot ulcers in a significant number of patients. Despite the danger posed by poor healing, very few specific therapies exist, leaving patients at risk of hospitalization, amputation, and further decline in overall health. Recent Advances: Redox signaling is a key regulator of wound healing, especially through its influence on the extracellular matrix (ECM). Read More

    Midterm Outcomes From a Pilot Study of Percutaneous Deep Vein Arterialization for the Treatment of No-Option Critical Limb Ischemia.
    J Endovasc Ther 2017 Jul 1:1526602817719283. Epub 2017 Jul 1.
    9 Vascular Surgery Unit, Department of Surgery, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Purpose: To report the initial clinical experience with percutaneous deep vein arterialization (PDVA) to treat critical limb ischemia (CLI) via the creation of an arteriovenous fistula.

    Methods: Seven patients (median age 85 years; 5 women) with CLI and no traditional endovascular or surgical revascularization options (no-option CLI) were recruited in a pilot study to determine the safety of PDVA. All patients were diabetic; 4 had Rutherford category 6 ischemia. Read More

    Total Contact Cast System to Heal Diabetic Foot Ulcers.
    Surg Technol Int 2017 Jul;30:71-76
    Surgical Services, Circleville Foot & Ankle and Berger Health System, Circleville, Ohio.
    Off-loadinga diabetic foot ulcer is a cornerstone of quality wound care for diabetic patients to allow cellular growth in the wound bed. While total contact casts (TCC) have been described as the gold standard for off-loading the wound, the complexity of application and the time commitment for both application and drying have discouraged health professionals from using them. This retrospective case series, conducted in a podiatric practice, evaluated using a TCC system that helps address the three components in which guidelines should be addressed when caring for a diabetic foot: V - vascular management, I - infection management and prevention, and P - pressure relief. Read More

    Implications of antimicrobial combinations in complex wound biofilms containing fungi.
    Antimicrob Agents Chemother 2017 Jul 10. Epub 2017 Jul 10.
    Oral Sciences Research Group, Glasgow Dental School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
    Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this we used an in vitro biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while mono-treatment approaches influenced biofilm composition it had no discernible effect on overall quantity. Read More

    Optimisation of rocker sole footwear for prevention of first plantar ulcer: comparison of group-optimised and individually-selected footwear designs.
    J Foot Ankle Res 2017 6;10:27. Epub 2017 Jul 6.
    Centre for Health Sciences Research, University of Salford, Salford, Manchester, M6 6PU UK.
    Background: Appropriate footwear for individuals with diabetes but no ulceration history could reduce the risk of first ulceration. However, individuals who deem themselves at low risk are unlikely to seek out bespoke footwear which is personalised. Therefore, our primary aim was to investigate whether group-optimised footwear designs, which could be prefabricated and delivered in a retail setting, could achieve appropriate pressure reduction, or whether footwear selection must be on a patient-by-patient basis. Read More

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