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Foot (Edinb) 2018 Oct 9;38:54-60. Epub 2018 Oct 9.

Université du Québec à Trois-Rivières, Nursing Department, 3351, boul. des Forges, C.P. 500, Trois-Rivières, Québec, G9A 5H7, Canada. Electronic address:

Diabetic foot ulcers (DFUs) are one of the main complications of diabetes affecting many Canadians that need to be effectively managed. There is limited data concerning outcomes of Canadian patients with DFUs treated with a team approach in the public health system. Podiatrists are known to be key members of a multidisciplinary team approach to DFUs management, but in Quebec, Canada, they are only available in private practice. Read More

Endocr Metab Immune Disord Drug Targets 2019 Jan 11. Epub 2019 Jan 11.

Cukurova University Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology, Adana. Turkey.

Objective: We aimed to investigate the etiology and prevalence of anemia in patients with diabetic foot ulcers and the relationship between both microvascular complications and related conditions and anemia.

Method: We retrospectively collected and evaluated the data of 225 patients with diabetic foot ulcer followed at our clinic. The demographic characteristics of the patients were analyzed. Read More

Photodiagnosis Photodyn Ther 2019 Jan 8. Epub 2019 Jan 8.

Department of Pharmacy, First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Background: Antibiotic resistance has emerged as one of the most important determinants in diabetic foot infections outcomes. Photodynamic antimicrobial chemotherapy (PACT) has been proposed as an alternative approach for inactivating bacteria, especially resistant bacterial biofilms. This research investigated the synergistic effects of PACT mediated by the photosensitizer indocyanine green (ICG) and ethylenediamine tetraacetate (EDTA) combined with antibiotics against common pathogens of diabetic foot ulcer infection, including Staphylococcus aureus and Pseudomonas aeruginosa, in vitro. Read More

JAMA Ophthalmol 2019 Jan 10. Epub 2019 Jan 10.

Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan.

Importance: Diabetic retinopathy is the leading cause of blindness in working-age adults. Studies have suggested that statins may reduce the risk of developing diabetic retinopathy.

Objective: To investigate the association between statin therapy and the development of diabetic retinopathy in patients with diabetes and dyslipidemia. Read More

Nanomaterials (Basel) 2019 Jan 8;9(1). Epub 2019 Jan 8.

Laboratorio de Inmunología y Virología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Pedro de Alba s/n, San Nicolas de los Garza, Nuevo León 66455, Mexico.

The development of new nanomaterials to promote wound healing is rising, because of their topical administration and easy functionalization with molecules that can improve and accelerate the process of healing. A nanocomposite of gold nanoparticles (AuNPs) functionalized with calreticulin was synthetized and evaluated. The ability of the nanocomposite to promote proliferation and migration was determined in vitro, and in vivo wound healing was evaluated using a mice model of diabetes established with streptozotocin (STZ). Read More

J Wound Care 2019 Jan;28(1):30-37

Professor, Health Sciences University, Gülhane Training and Research Hospital, Department of Endocrinology and Metabolism Etlik-Ankara, Turkey.

Objective:: To examine the experiences of patients with diabetic foot ulcers (DFUs).

Method:: This qualitative study, using patient interviews, focused on how inpatients receiving treatment for diabetes experience the disease. Patients were selected using a purposive sampling method. Read More

Expert Rev Pharmacoecon Outcomes Res 2019 Jan 9. Epub 2019 Jan 9.

b Chief, Department of Foot and Ankle Surgery , Geisinger Community Medical Center , Scranton , PA , USA.

Introduction: Diabetic foot ulcer (DFU) prevalence is as high as 25% and 40-80% of DFUs become infected (DFI). About 20% of infected ulcers will spread to bone causing diabetic foot osteomyelitis (DFO). DFU costs Medicare $9-13 billion/year. Read More

J Med Microbiol 2019 Jan 9. Epub 2019 Jan 9.

4​Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Purpose: While some micro-organisms, such as Staphylococcus aureus, are clearly implicated in causing tissue damage in diabetic foot ulcers (DFUs), our knowledge of the contribution of the entire microbiome to clinical outcomes is limited. We profiled the microbiome of a longitudinal sample series of 28 people with diabetes and DFUs of the heel in an attempt to better characterize the relationship between healing, infection and the microbiome.

Methodology: In total, 237 samples were analysed from 28 DFUs, collected at fortnightly intervals for 6 months or until healing. Read More

Stem Cells Transl Med 2019 Jan 9. Epub 2019 Jan 9.

The Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, People's Republic of China.

Systematic abnormalities cause several complications in diabetes patients. Impaired wound healing is a serious complication that leads to severe foot ulcer and amputation. Mesenchymal stem cells (MSCs) have been considered a promising strategy for promoting wound healing due to their paracrine function. Read More

Am J Manag Care 2018 Dec;24(14 Spec No.):SP607-SP608

JAMA 2019 Jan;321(1):114

J Foot Ankle Surg 2019 Jan 3. Epub 2019 Jan 3.

Professor, Department of Orthopaedics and Traumatology, Medicana Bahcelievler Hospital, Istanbul, Turkey.

Epidermal growth factor is used as an adjuvant to close the wound in addition to standard care in diabetic foot ulcers. This study aimed to investigate the long-term outcomes after intralesional epidermal growth factor injections in the treatment of diabetic foot ulcers. Thirty-six feet of 34 patients (n = 34) with diabetic foot ulcers were included. Read More

J Wound Ostomy Continence Nurs 2019 Jan/Feb;46(1):25-29

Azam Malekiam, MSc, Maggot Debridement Therapy Clinic, Iranian Center for Wound Healing, Academic Center for Education, Culture and Research (ACECR), Tehran, Iran; and Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Gholamreza Esmaeeli Djavid, MD, Maggot Debridement Therapy Clinic, Iranian Center for Wound Healing, ACECR, Tehran, Iran; and Medical Laser Research Center, ACECR, Tehran, Iran. Kamran Akbarzadeh, PhD, Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Mehdi Soltandallal, PhD, Department of Medical Pathology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Yavar Rassi, PhD, Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Javad Rafinejad, PhD, Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Abbas Rahimi Forooshani, PhD, Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Amirreza Farhoud, Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Ronak Bakhtiary, Department of Medical Pathology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: This study was conducted to evaluate the antimicrobial effects of medicinal maggots of Lucilia sericata on Staphylococcus aureus and Pseudomonas aeruginosa on diabetic foot ulcers (DFUs).

Design: Randomized controlled trial.

Subjects And Setting: The sample comprised 50 adult patients from the clinic of the Academic Center for Education, Culture and Research of Tehran University of Medical Sciences, Iran. Read More

Stem Cells Dev 2019 Jan 4. Epub 2019 Jan 4.

Affiliated Hospital of Zunyi Medical College, 159358, Plastic Surgery, Zunyi, China , 563003 ;

Adipose-derived stem cells (ASCs) possess a well-characterized capacity to enhance cutaneous wound healing. However, many controversies exist regarding ASCs from diabetic patients (dASCs).No report exists on the administration of dASCs for the treatment of pressure ulcers. Read More

J Vasc Surg 2019 Jan 1. Epub 2019 Jan 1.

Diabetic Foot and Wound Service, The Johns Hopkins Hospital, Baltimore, Md; Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Md; Center for Surgical Trials and Outcomes Research, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Md. Electronic address:

Objective: Increasing Wound, Ischemia, and foot Infection (WIfI) stage has previously been shown to be associated with prolonged wound healing time, higher number of surgical procedures, and increased cost of care in patients with diabetic foot ulcers (DFUs) treated in a multidisciplinary setting. However, the profitability of this care model is unknown. We aimed to quantify the hospital costs and net margins associated with multidisciplinary DFU care. Read More

BMC Endocr Disord 2019 Jan 3;19(1). Epub 2019 Jan 3.

Department of Endocrinology, Royal Darwin Hospital, Darwin, Northern Territory, Australia.

Background: Diabetic foot ulcers (DFU) are a common problem in longstanding diabetes. However, mortality outcomes in Australian patients with DFU are still unclear.

Methods: All patients with DFU presenting for the first time to the Multi-Disciplinary Foot Clinic (MDFC) at Royal Darwin Hospital, Northern Territory Australia, between January 2003 and June 2015 were included in this study. Read More

Vnitr Lek 2018 ;64(11):1098-1104

Chronic non-healing wounds represent a frequent comorbidity among geriatric patients. Non-healing wounds increase patients morbidity and mortality and significantly decrease their quality of life. Prognosis of these wounds depends on etiology, overall health condition of the patient and also on the proper treatment. Read More

Biomark Med 2019 Jan 3. Epub 2019 Jan 3.

Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430021, PR China.

Aim: The aim of this study was to investigate the relationship between CXCL-6 levels in wound exudates and healing of diabetic foot ulcers (DFU).

Materials & Methods: One hundred patients with neuropathic DFU were recruited. Wound exudate CXCL-6 levels were measured by enzyme-linked immunosorbent assay. Read More

Scand J Caring Sci 2019 Jan 3. Epub 2019 Jan 3.

Doctor of Philosophy Program in Nursing (International and Collaborative Program with Foreign Universities), Mahidol University, Thailand.

Background: Diabetic foot ulcer care demonstrates a beneficial approach to overcoming problems in patients with diabetes. This approach is frequently given but is not always successfully implemented due to its fragmentation amid healthcare providers. What's more, there are a number of different understandings, interchangeable languages and an absence of uniformity overlapping terminologies of meaning for diabetic foot ulcer care. Read More

Int Wound J 2019 Jan 2. Epub 2019 Jan 2.

Department of Orthopedic Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Chronic diabetic foot ulcers (DFUs) are a common problem in patients with diabetes and are often difficult to treat. The application of newly developed dressing material in patients with chronic DFUs has been reported to be effective. The purpose of this study was to evaluate the usefulness of allogeneic keratinocyte treatment for chronic DFUs. Read More

CEN Case Rep 2019 Jan 2. Epub 2019 Jan 2.

Department of Renal Surgery and Transplantation, Jichi Medical University Hospital, 3311-1 Yakushiji, Shimotsuke, Tochigi, 3290498, Japan.

Fibrosing cholestatic hepatitis (FCH) is a fatal disorder that presents as a progressive deterioration of liver function over a period of several weeks to several months. It is caused by the direct cytotoxic effect of the over-expression of viral antigens on hepatocytes in immunosuppressed patients. Our patient was a 59-year-old man with hepatitis C virus (HCV) infection of genotype 2a who had suffered from end-stage renal disease due to diabetic nephropathy and underwent kidney transplantation. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Oct;32(10):1261-1266

Department of Bone and Joint Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning Guangxi, 530021,

Objective: To evaluate the effectiveness of Ilizarov technique-based transverse tibial bone transport on the treatment of severe diabetic foot ulcer (Wagner grades 3 to 5) complicated with systemic inflammatory response syndrome (SIRS).

Methods: Between August 2014 and December 2017, 33 patients with severe diabetic foot and SIRS were treated with Ilizarov technique-based transverse tibial bone transport. There were 27 males and 6 females, with a mean age of 60. Read More

Eur J Clin Invest 2019 Jan 1:e13067. Epub 2019 Jan 1.

Department of Metabolic Diseases, Jagiellonian University Medical College Krakow, Poland.

Background: Diabetes and its complications constitute a rising medical challenge. Special attention should be given to diabetic foot syndrome (DFS) due to its high rate of associated amputation and mortality. Negative pressure wound therapy (NPWT) is a frequently used supportive modality in a diabetic foot with ulcerations (DFUs). Read More

Prim Care Diabetes 2018 Dec 29. Epub 2018 Dec 29.

Department of Endocrinology and Metabolism, Gaziantep University School of Medicine, Gaziantep, Turkey.

Introduction: Medical and surgical treatment options are available for patients with diabetic foot ulcers. In more severe cases, amputation decisions are determined by patient comorbidities, performance, imaging studies, and clinical examination results. However, an objective indicator that predicts how this amputation process will end has not yet been clarified. Read More

Rev Sci Instrum 2018 Dec;89(12):125116

Bioengineering Program, Department of Mechanical Engineering, University of Michigan at Dearborn, Dearborn, Michigan 48128, USA.

In contrast to labor intensive and destructive histological techniques, intrinsic autofluorescence lifetimes of extra cellular matrix proteins can provide label-free imaging of tissue modifications in diseases, including the diabetic ulcers. However, decoupling the complex mixture of tissue fluorophores requires costly and complicated fluorescent lifetime instrumentation. Furthermore, a list of autofluorescent and fluorogenic proteins must be characterized to profile their changes during disease progression. Read More

J Pharm Sci 2018 Dec 29. Epub 2018 Dec 29.

Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

This work aimed at loading of diosmin nanocrystals into alginate based wafers for treatment of highly exuding diabetic ulcer in rats using topical route of administration. For this purpose, different formulation variables and preparation techniques to enhance the flexibility and adhesion properties of the prepared sodium alginate wafers was carried out. The prepared wafers were characterized regarding, hydration capacity, bioadhesion , scanning electron microscope (SEM), and (FT-IR). Read More

J Am Coll Clin Wound Spec 2017 7;9(1-3):19-23. Epub 2018 Jun 7.

Dasman Diabetes Institute, Kuwait.

Total contact casts are recognized as the gold standard treatment for neuropathic plantar diabetic foot ulceration, endorsed by all national and international consensus papers. Despite this, research has shown that there is a dichotomy between the existing evidence which supports the use of total contact casts in the management of diabetic foot ulcers and its use in clinical practice. This article aims to highlight the benefits, risks, and barriers associated with total contact cast use in the management of diabetic foot ulcers in the clinical setting, with an emphasis on existing research carried out in this field to encourage change in clinical practice and utilization of this effective treatment modality. Read More

J Am Coll Clin Wound Spec 2017 9;9(1-3):14-18. Epub 2018 Oct 9.

Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Introduction: Peripheral Arterial Disease (PAD) affects approximately 8 million patients in the United States. We investigate the relationship of Skin Perfusion Pressure (SPP) and wound closure time in lower extremity wounds.

Methods: We conducted a retrospective study of 1125 lower extremity wounds in 998 patients between June 2006 and October 2014 in our wound clinic. Read More

Int Wound J 2018 Dec 26. Epub 2018 Dec 26.

Diabetic Foot Unit, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.

The aim of this study was to evaluate the recovery time and the development of complications in the dorsal and plantar approach to metatarsal head resections (MHR) in patients with diabetic foot ulcers complicated by osteomyelitis. A retrospective study was carried out involving 108 patients who underwent MHRs for the treatment of diabetic foot osteomyelitis. Two cohorts were defined: dorsal approach with incision closed with sutures and plantar approach with ulcer healed using conservative treatment. Read More

Int Wound J 2018 Dec 26. Epub 2018 Dec 26.

LDS Hospital, Salt Lake City, Utah.

J Clin Aesthet Dermatol 2018 Nov 1;11(11):36-39. Epub 2018 Nov 1.

Dr. Del Rosso is with JDR Dermatology Research/Thomas Dermatology in Las Vegas, Nevada and Touro University Nevada in Henderson, Nevada.

and studies have supported antimicrobial, anti-inflammatory, and other biologic properties of hypochlorous acid (HOCl), which has led to its use in the treatment of skin wounds, pruritus, diabetic ulcers, and some inflammatory skin disorders. Research has also shown that the physiochemical properties of HOCl after application to skin are highly dependent on both pH and formulation stability. In this review, the authors discuss a core HOCI formulation (Microcyn® Technology, Sonoma Pharmaceuticals, Petaluma, California) that is stable for up to two years, noncytotoxic, and pH-neutralized to augment therapeutic activity, skin tolerability, and stability. Read More

Colloids Surf B Biointerfaces 2018 Dec 11;175:636-643. Epub 2018 Dec 11.

Faculty of Pharmacy, Sri Ramachandra Medical Centre and Research Institute, Chennai, Tamil Nadu, India. Electronic address:

Biomimetic nanofibrous scaffolds targeting multiple dysfunctional processes provide a multi-pronged strategy to restore functions and regenerate the damaged tissue. This study investigates a strategy of combining a regenerative component, Type I collagen Peptide (CP), along with a nitric oxide donor, S-Nitrosoglutathione (GSNO), in the form of nanofibrous scaffold to address the non-healing diabetic ulcer. Silk Fibroin-Polyvinyl alcohol (SF-PVA) nanofibrous scaffold is used as a carrier for delivering functional moieties. Read More

Biomed Pharmacother 2018 Dec 18;111:60-67. Epub 2018 Dec 18.

School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China. Electronic address:

Background: Calanthe fimbriata is a Tujia ethnic medicine with various medicinal value and it is traditionally used for the treatment of gastric ulcer, chronic hepatitis, pharyngitis, and so on.

Objective: The current study was conducted to evaluate the antidiabetic activity of C. fimbriata methanol extract (CfME) in oral glucose tolerance test (OGTT) mice and in streptozotocin (STZ)-induced diabetic mice. Read More

Ann Ist Super Sanita 2018 Oct-Dec;54(4):284-293

Physical Therapy, Speech and Occupational Therapy Department, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.

Plantar pressure is critical in the onset of neuropathic foot ulcers. However, risk classifications do not consider it as a stratification parameter. Whether plantar pressure distribution affects ulcer-risk was investigated. Read More

Diabetes Metab Res Rev 2018 Dec 21:e3119. Epub 2018 Dec 21.

Department of Plastic-, Reconstructive- and Hand surgery, Erasmus University Medical Center, Rotterdam, the Netherlands.

Aims: Current guidelines recommend screening the feet of diabetic subjects with a 10 g monofilament or tuning fork. We investigated which tests and locations on the feet have the best predictive value regarding one-year ulcer-free survival, in diabetic subjects participating in the prospective Rotterdam Diabetic Foot Study.

Methods: Decision tree analysis was used to predict ulcer free survival, based on responses from individual test locations (monofilaments on 10 sites, vibration sense was tested on both halluces and medial malleoli). Read More

Wound Repair Regen 2018 Dec 21. Epub 2018 Dec 21.

Health Services and Chronic Diseases Research Network (REDISSEC), Spain.

Foot ulcer is a major complication of diabetes mellitus and often precedes leg amputation. Among the different methods to achieve ulcer healing, the use of platelet-rich plasma, which is rich in multiple growth factors and cytokines and may have similarities to the natural wound healing process, is gaining in popularity. A systematic review with meta-analyses was performed to evaluate the safety and clinical effectiveness of platelet-rich plasma for the treatment of diabetic foot ulcers compared to standard treatment or any other alternative therapy. Read More

Case Rep Nephrol Dial 2018 Sep-Dec;8(3):239-245. Epub 2018 Nov 14.

Section of Nephrology, Department of Medicine, Regina, Saskatchewan, Canada.

Background: Pyoderma gangrenosum (PG) is a rare, chronic inflammatory condition exhibiting mucopurulent or hemorrhagic exudates. The majority of cases are associated with inflammatory bowel disease, rheumatological diseases, and hematological malignancies. In the absence of typical serological markers and specific histopathological changes, the diagnosis is often clinical. Read More

Medicine (Baltimore) 2018 Dec;97(51):e13803

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital.

Both diabetic peripheral neuropathy and peripheral arterial disease (PAD) cause foot ulcers and often result in non-traumatic amputations in patients with type 2 diabetes. This study aimed to evaluate the association between clinical variables, PAD, and subclinical diabetic small fiber peripheral neuropathy detected by abnormal thermal thresholds of the lower extremities in patients with type 2 diabetes.We investigated 725 consecutive patients with type 2 diabetes (male/female: 372/353; mean age, 67 ± 11 years) who did not have apparent cardiovascular disease (including coronary artery disease, arrhythmia, and stroke) and who underwent the quantitative sensory test for thermal (warm and cold) thresholds of the lower limbs and ankle-brachial index (ABI)/toe-brachial index (TBI) examinations in 2015. Read More

Adv Skin Wound Care 2019 Jan;32(1):19-25

At Brigham and Women's Hospital in Boston, Massachusetts, Yukun Liu, MD, was a Research Fellow at the time this manuscript was written; Adriana C. Panayi, MD, is a Research Fellow; Lauren R. Bayer, PA-C, is Clinical Director of the Wound Care Center; and Dennis P. Orgill MD, PhD is Director of the Wound Care Center, Department of Surgery, Brigham and Women's Hospital; and Professor of Surgery, Harvard Medical School. Acknowledgment: Dr Orgill is a consultant and/or receives research funding from Integra LifeSciences Corporation, the Musculoskeletal Research Foundation, Geistlich Corporation, Acell Corporation, and Professional Education and Research Incorporated. The authors have disclosed no other financial relationships related to this article. Submitted May 18, 2018; accepted June 29, 2018.

The occurrence of diabetic foot ulcers and venous leg ulcers is increasing because of aging population trends as well as increases in the number of people with diabetes and obesity. New technologies have been developed to treat these conditions, whereas other technologies previously designed for burns and traumatic wounds have been adapted. This article reviews the development of selected skin replacement technologies, particularly cellular and tissue-based products, highlighting their effectiveness on diabetic foot ulcers, venous leg ulcers, and burns. Read More

Rev Esc Enferm USP 2018 Dec 20;52:e03415. Epub 2018 Dec 20.

Universidade Federal do Piauí, Departamento de Enfermagem, Programa de Pós-Graduação em Enfermagem. Teresina, PI, Brazil.

Objective: To analyze the prevalence of pressure injuries, diabetic and vasculogenic ulcers and associated factors in older adults attended in primary care.

Method: A cross-sectional, analytical study with older adults attended in the Family Health Strategy in a Brazilian municipality. Data collection was performed from January to March 2016 using interviews and evaluations of injuries. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Dec;32(12):1576-1580

Department of Hand Surgery, Repair and Reconstruction Surgery, Lower Limb Vascular Disease, the Second Hospital of Tangshan (the Affiliated Hospital of North China Polytechnic University), Tangshan Hebei, 063000, P.R.China.

Objective: To discuss the effectiveness of femoral-femoral artery bypass grafting combined with transverse tibial bone transporting in treatment of lower extremity arteriosclerosis obliterans (ASO) or combined with diabetic foot.

Methods: Between March 2014 and June 2016, 9 patients with lower extremity ASO or combined with diabetic feet were treated with femoral-femoral artery bypass grafting and transverse tibial bone transporting. All patients were male, aged from 63 to 82 years with an average of 74. Read More

ACG Case Rep J 2018 28;5:e83. Epub 2018 Nov 28.

Department of Pathology, Hartford Hospital, Hartford, CT.

Sevelamer carbonate is a commonly prescribed anion-exchange resin administered orally to prevent hyperphosphatemia in patients with chronic kidney disease. We present a rare case of a 33-year-old man with end-stage renal disease and diabetic gastroparesis on sevelamer carbonate, who presented with hematochezia and was found to have rectosigmoid ulcers induced by sevelamer crystals. His hematochezia resolved after switching from sevelamer carbonate to lanthanum carbonate. Read More

Foot Ankle Spec 2018 Dec 19:1938640018819784. Epub 2018 Dec 19.

Department of Orthopedic Surgery, Lebanese American University Medical Center, Rizk Hospital, Lebanese American University, School of Medicine, Beirut, Lebanon (KY, MN, CA).

Diabetic foot ulcers (DFUs) are usually treated with conservative management based on debridement, topical agents, and nonsurgical off-loading; however, the recurrence rate following such standard care is reported to be high. In the case of recalcitrant or recurrent ulcers, a surgical off-loading technique such as the metatarsal osteotomy (MO) is indicated. Thus, the aim of this study is to conduct a meta-analysis evaluating the efficacy of MO in treating DFUs. Read More

Qual Life Res 2018 Dec 18. Epub 2018 Dec 18.

School of Nursing, Faculty of Science, Medicine and Health, University of Wollongong, Building 41, Wollongong, NSW, 2522, Australia.

Purpose: To undertake a systematic review of the literature to investigate the HRQOL among adults living with DFUs.

Methods: A systematic search of the medical and nursing/health content databases including MEDLINE, CINAHL, and PsycINFO was conducted up to November 2018. The methodological quality of each study was assessed independently by all authors using the Joanna Briggs Institute checklist. Read More

Vascular 2018 Dec 18:1708538118816267. Epub 2018 Dec 18.

2 Fundacion Universitaria Autonoma de las Americas. Pereira, Colombia.

Objectives: To determine the indications for the use, potential benefits, and adverse reactions of alprostadil in a group of Colombian patients.

Methods: A retrospective cross-sectional study was conducted in patients diagnosed with critical limb ischemia who received alprostadil in five hospitals in Colombia between September 2011 and July 2017. We reviewed the clinical records of each patient to obtain the sociodemographic and pharmacological variables, clinical stages, complications, comorbidities, reported effectiveness and adverse reactions. Read More

Open Access Maced J Med Sci 2018 Nov 15;6(11):2206-2213. Epub 2018 Nov 15.

University of Tabuk, Tabuk, Saudi Arabia.

Background: Diabetes mellitus places a substantial burden on society worldwide. Diabetic foot ulcers are a challenging problem for clinicians. Six generally accepted detriments to the healing of diabetic foot ulcers were identified: infection, glycaemic control, vascular supply, smoking, nutrition and deformity. Read More

Pak J Med Sci 2018 Nov-Dec;34(6):1375-1380

Zohaib Abbas Khan, Director technical (Add), Drug Testing Laboratory, Punjab, Rawalpindi.

Objective: Although many studies worldwide explained the risk factors for developing Diabetic Foot Ulceration (DFU), little has been done to assess medical factors in DFU formation and link them in patients of Pakistan. This study aimed to link the DFU with different risk factors.

Methods: This descriptive cross-sectional retrospective study was conducted in Diabetes Endocrine and Metabolic Centre / Post Graduate Medical Institute / Lahore General Hospital. Read More

J Med Internet Res 2018 Dec 17;20(12):e12460. Epub 2018 Dec 17.

Siren Care Inc, San Francisco, CA, United States.

Background: Over 30 million people in the United States (over 9%) have been diagnosed with diabetes. About 25% of people with diabetes will experience a diabetic foot ulcer (DFU) in their lifetime. Unresolved DFUs may lead to sepsis and are the leading cause of lower-limb amputations. Read More

J Wound Care 2018 12;27(12):849-855

Assistant Professor, Department of Pathology, Phramongkutklao College of Medicine, Bangkok 10400, Thailand

Objectives: The mechanism of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in diabetic foot ulcers (DFUs) is unclear. The purpose of this study was to describe changes in MMP-1, MMP-9, and TIMP-1 levels during DFU healing, and to search for any correlation in the changes in MMP levels with wound healing, in order to find possible predictors of healing.

Methods: Patients with a DFU were recruited and placed into two groups, according to the degree of wound healing: 'good healers' and 'poor healers'. Read More

J Wound Care 2018 Dec;27(12):837-842

Assistant Professor-Senior Scale, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Objective:: Low-level laser therapy (also known as photobiomodulation therapy, PBMT) promotes accelerated healing of diabetic foot ulcers (DFUs), thereby preventing the risk of future complications and amputation. The aim of this study was to determine the effect of PBMT, with structured, graded mobilisation and foot care, on DFU healing dynamics.

Method:: Patients diagnosed with type 2 diabetes, diabetic peripheral neuropathy and presenting with a chronic neuroischaemic DFU, were treated with PBMT using scanning and non-contact probe methods. Read More