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    1 OF 138

    Evaluation of short exposure times of antimicrobial wound solutions against microbial biofilms: from in vitro to in vivo.
    J Antimicrob Chemother 2017 Nov 18. Epub 2017 Nov 18.
    Surgical Infection Research Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.
    Objectives: Test the performance of topical antimicrobial wound solutions against microbial biofilms using in vitro, ex vivo and in vivo model systems at clinically relevant exposure times.

    Methods: Topical antimicrobial wound solutions were tested under three different conditions: (in vitro) 4% w/v Melaleuca oil, polyhexamethylene biguanide, chlorhexidine, povidone iodine and hypochlorous acid were tested at short duration exposure times for 15 min against 3 day mature biofilms of Staphylococcus aureus and Pseudomonas aeruginosa; (ex vivo) hypochlorous acid was tested in a porcine skin explant model with 12 cycles of 10 min exposure, over 24 h, against 3 day mature P. aeruginosa biofilms; and (in vivo) 4% w/v Melaleuca oil was applied for 15 min exposure, daily, for 7 days, in 10 patients with chronic non-healing diabetic foot ulcers complicated by biofilm. Read More

    Adenine accelerated the diabetic wound healing by PPAR delta and angiogenic regulation.
    Eur J Pharmacol 2017 Nov 18. Epub 2017 Nov 18.
    Department and Institute of Life Science, Fu-Jen Catholic University, New Taipei City, Taiwan; Graduate Institute of Applied Science and Engineering, Fu-Jen Catholic University, New Taipei City, Taiwan. Electronic address:
    Wound healing is one of the major complications of diabetes, and problems with wound healing in diabetics often lead to amputation and even death. AMP-activated protein kinase (AMPK) is a protein involved in intracellular metabolism. Activated AMPK can reduce visceral fat and cholesterol synthesis and even inhibit hepatic gluconeogenesis. Read More

    The chlorite-based drug WF10 constantly reduces hemoglobin A1c values and improves glucose control in diabetes patients with severe foot syndrome.
    J Clin Transl Endocrinol 2016 Jun 5;4:53-58. Epub 2016 May 5.
    OXO Chemie (Thailand) Co., Ltd., Bangkok, Thailand.
    Aims: The intravenous application of the chlorite-based drug solution WF10 is known to improve wound healing in patients with diabetic foot syndrome. In this retrospective study, we addressed the question, which effects are caused by this drug in patients with diabetic foot ulcers on the hemoglobin A1c value.

    Methods: Patients received five consecutive daily infusions of WF10. Read More

    Outcomes of hospitalized diabetic foot patients in a multi-disciplinary team setting: Thailand's experience.
    J Clin Transl Endocrinol 2014 Dec 15;1(4):187-191. Epub 2014 Oct 15.
    Diabetes and Thyroid Center, Theptarin Hospital, 3858 Rama IV Rd, Klong Toey, Bangkok 10110, Thailand.
    Aims: The aims of this study were to evaluate the outcomes of treatment among hospitalized patients with diabetic foot ulcers, the risk factors for non-healing ulcers, and the rate of major amputation among Thai patients.

    Methods: A retrospective study of hospitalized diabetic foot patients treated at Theptarin Hospital during the period of 2009-2013. The complete healing rate was assessed at 12 months after admission. Read More

    Curative Metatarsal Bone Surgery Combined with Intralesional Administration of Recombinant Human Epidermal Growth Factor in Diabetic Neuropathic Ulceration of the Forefoot: A Prospective, Open, Uncontrolled, Nonrandomized, Observational Study.
    Curr Ther Res Clin Exp 2017 7;85:2-7. Epub 2017 Apr 7.
    Vascular Surgery Service of the Clinic Surgical Hospital "José R. López Tabrane", Matanzas University of Medical Sciences, Matanzas City, Matanzas, Cuba.
    Background: Curative surgery is performed for a foot with ulcers and loss of protective sensation to heal the wound and prevent amputation. Evidence supports that patients with diabetes have decreased concentrations of growth factors in their tissues, notably epidermal growth factor (EGF). Injecting EGF deep into the bottom of the wound and its contours encourages a more effective response in terms of granulation tissue growth and wound closure. Read More

    Topical mevastatin promotes wound healing by inhibiting the transcription factor c-Myc via the glucocorticoid receptor and the long noncoding RNA Gas5.
    J Biol Chem 2017 Nov 20. Epub 2017 Nov 20.
    University of Miami Miller School of Medicine, United States;
    Diabetic foot ulcers (DFU), a life-threatening complication of diabetes mellitus, have limited treatment options, often resulting in amputations. HMG-CoA reductase inhibitors such as statins are cholesterol-reducing agents that may provide a new therapeutic option. Statins target the cholesterol pathway and block the synthesis of the wound-healing inhibitors farnesyl pyrophosphate (FPP) and cortisol, ligands for the glucocorticoid receptor (GR). Read More

    Relationship between selected micronutrient deficiencies and oxidative stress biomarkers in diabetes mellitus patients with foot ulcers in Ibadan, Nigeria
    Turk J Med Sci 2017 08 23;47(4):1117-1123. Epub 2017 Aug 23.
    Background/aim: Micronutrients are indispensable in the prevention of diseases and maintenance of good health. Their deficiencies have been implicated in several diseases associated with oxidative stress (OS). This study aimed at investigating the levels of some vitamins and minerals in association with OS markers in diabetic foot ulcer (DFU) patients in Ibadan, Oyo State, Nigeria. Read More

    Evaluation of major and minor lower extremity amputation in diabetic foot patients
    Turk J Med Sci 2017 08 23;47(4):1109-1116. Epub 2017 Aug 23.
    Background/aim: We evaluated the existing risk factors with clinical results in patients who underwent major and minor amputation of the lower extremity as a result of diabetic foot ulcers (DFUs). Materials and methods: We retrospectively studied 107 patients who had undergone lower extremity amputation. The patients were divided into minor (Group 1, n = 75) and major (Group 2, n = 32) amputation groups. Read More

    Relationship between person's health beliefs and diabetes self-care management regimen.
    J Vasc Nurs 2017 Dec 2;35(4):187-192. Epub 2017 Aug 2.
    Department of Nursing, College of Nursing, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
    Purpose: To examine the relationship between the health beliefs of Saudi adults with type 2 diabetes mellitus (T2DM) and their adherence to daily diabetes self-care management regimen. A secondary aim was to examine the health beliefs of adults with a diabetic foot ulcer (DFU) and participants without a DFU.

    Method: Descriptive correlational design with a convenience sample of 30 participants. Read More

    Intralesional epidermal growth factor therapy fordiabetic foot ulcers: an evaluation of 15 cases
    Turk J Med Sci 2017 11 13;47(5):1500-1504. Epub 2017 Nov 13.
    Background/aim: Intralesional recombinant epidermal growth factor (EGF) is a new treatment approach for diabetic foot ulcer, approved in 2006. EGF therapy is given as an adjunct to the standard treatment regimen of antibiotics, surgery, and hyperbaric oxygen. EGF accelerates the healing of diabetic foot ulcers and reduces healing time. Read More

    Enhanced antibacterial effects of green synthesized ZnO NPs using Aristolochia indica against Multi-drug resistant bacterial pathogens from Diabetic Foot Ulcer.
    J Infect Public Health 2017 Nov 14. Epub 2017 Nov 14.
    Department of Zoology, Faculty of Science, Annamalai University, Chidambaram 608002, Tamil Nadu, India.
    Background: Increased incidence of Multi-drug resistance in microorganisms has become the greatest challenge in the treatment of Diabetic Foot Ulcer (DFU) and urges the need of a new antimicrobial agent. In this study, we determined the bactericidal effects of ZnO nanoparticles (ZnO NPs) green synthesized from Aristolochia indica against Multi-drug Resistant Organisms (MDROs) isolated from pus samples of DFU patients attending in a tertiary care hospital in South India.

    Methods: ZnO NPs were characterized by UV-vis-DRS spectroscopy, Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM) and for its zeta potential value. Read More

    Growth factors for diabetic foot ulcers: Mixed treatment comparison analysis of randomized clinical trials.
    Br J Clin Pharmacol 2017 Nov 17. Epub 2017 Nov 17.
    Department of Oral Health, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji.
    Aims: Topical growth factors accelerate wound healing in patients with diabetic foot ulcers (DFU). Due to the absence of head to head comparisons, we carried out Bayesian network meta-analysis to compare the efficacy and safety of growth factors.

    Methods: Using an appropriate search strategy, randomized controlled trials on topical growth factors compared with standard of care in patients with DFU, were included. Read More

    A Series of 210 Peripheral Arterial Disease Below-Knee Amputations and Predictors for Subsequent Above-Knee Amputations.
    Ann Vasc Dis 2017 Sep;10(3)
    Vascular Surgery Service, Department of General Surgery, Tan Tock Seng Hospital, Singapore.
    Objective: To review patient characteristics and outcomes after peripheral arterial disease (PAD)-related below-knee amputation (BKA), and identify risk factors predicting subsequent above-knee amputation (AKA). Materials and Methods: A retrospective study of 210 BKAs between May 2008 and December 2015. Results: The mean age of the study population was 66 years. Read More

    Nutrition and Lower Extremity Ulcers: Causality and/or Treatment.
    Int J Low Extrem Wounds 2017 Nov 1:1534734617737639. Epub 2017 Nov 1.
    1 Tennessee Valley VA Hospital, Nashville, TN, USA.
    The association between malnutrition, impaired wound healing, and the presence of chronic wounds has been recognized for a long time. It is widely believed that the lack of adequate nutrition increases the risk of developing wounds which have a great likelihood of progressing to chronicity due to lack of appropriate healing responses. This risk is particularly high in the aging population. Read More

    Micronutrients and Natural Compounds Status and Their Effects on Wound Healing in the Diabetic Foot Ulcer.
    Int J Low Extrem Wounds 2017 Nov 1:1534734617737659. Epub 2017 Nov 1.
    1 NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand.
    The diabetic foot ulcer (DFU) is an invariably common complication of diabetes mellitus, it is also a significant cause of amputation as well as extended hospitalization. As most patients with DFU suffer from malnutrition, which has been related to improper metabolic micronutrients status, alterations can affect impaired wound healing process. Micronutrients and herbal remedies applications present a wide range of health advantages to patients with DFU. Read More

    Effect of oil gauze silver dressings on diabetic foot ulcers in the elderly.
    Pak J Med Sci 2017 Sep-Oct;33(5):1091-1094
    Hong Du, Cardiology Ward, Yantai Yuhuangding Hospital, Yantai, Shandong, 264000, China.
    Objective: To compare the clinical efficacy and safety of oil gauze silver dressing and silver ions dressing on diabetic ulcers in elderly outpatients.

    Methods: Twenty-two patients with Type-2 diabetic foot ulcers were included in the study conducted at Yantai Yuhuangding Hospital between April 2013 and April 2014. At the time of enrolment they were divided into the silver ions and oil gauze silver groups based on the order of admission. Read More

    Predictive Laboratory Findings of Lower Extremity Amputation in Diabetic Patients: Meta-analysis.
    Int J Low Extrem Wounds 2017 Nov 1:1534734617737660. Epub 2017 Nov 1.
    1 Medical School of Chonbuk National University, Jeonju, Republic of Korea.
    Lower extremity amputation is a source of morbidity and mortality among diabetic patients. This meta-analysis aimed to identify significant laboratory data in patients with diabetic foot ulcer with high rates of lower extremity amputation. We performed a systematic literature review and meta-analysis using MEDLINE, EMBASE, and Cochrane databases. Read More

    Antimicrobial Efficacy of Penicillium amestolkiae elv609 Extract Treated Cotton Fabric for Diabetic Wound Care.
    Mycobiology 2017 Sep 30;45(3):178-183. Epub 2017 Sep 30.
    Universiti Kuala Lumpur, Malaysian Institute of Chemical and Bioengineering Technology, 78000 Alor Gajah, Melaka, Malaysia.
    Diabetes mellitus is a chronic disorder which affects millions of population worldwide. Global estimates published in 2010 reported the world diabetic prevalence as 6.4%, affecting 285 million adults. Read More

    Ciprofloxacin-loaded calcium alginate wafers prepared by freeze-drying technique for potential healing of chronic diabetic foot ulcers.
    Drug Deliv Transl Res 2017 Nov 13. Epub 2017 Nov 13.
    Department of Pharmaceutical, Chemical & Environmental Sciences, Faculty of Engineering and Science, University of Greenwich, Medway, Central Ave. Chatham Maritime, Kent, ME4 4TB, UK.
    Calcium alginate (CA) wafer dressings were prepared by lyophilization of hydrogels to deliver ciprofloxacin (CIP) directly to the wound site of infected diabetic foot ulcers (DFUs). The dressings were physically characterized by scanning electron microscopy (SEM), texture analysis (for mechanical and in vitro adhesion properties), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). Further, functional properties essential for wound healing, i. Read More

    Diabetes-related amputations create considerable public health burden in the UK.
    Diabetes Res Clin Pract 2017 Nov 10. Epub 2017 Nov 10.
    Neem Biotech Ltd., Units G and H, Roseheyworth Business Park, Roseheyworth, Abertillery, Blaenau Gwent NP13 1SX, Wales, UK.
    Aims: The main aim of this study was to assess the cost of diabetic amputation (both direct and indirect) to the National Health Service from the point of amputation onwards.

    Methods: This systematic review involved searches of published literature between January 2007 and March 2017 mainly using the bibliographic databases, the Cochrane Library, EMBASE via Ovid(®), MEDLINE via Ovid(®), as well as grey literature, both in print and in electronic formats published through non-commercial publications, which reported the cost of amputation due to diabetic foot ulcers RESULTS: The studies included in this review varied considerably in estimating the cost including cost elements and how those costs were categorised. The cost estimates for inpatient care associated with amputation involving admissions or procedures on amputation stumps in people with diabetes was £43. Read More

    Combined use of modulated ultrasound and electric current stimulation for diabetic foot ulcers: a case series.
    J Wound Care 2017 Nov;26(11):632-640
    Research Assistant, School of Nursing & Midwifery, Royal College of Surgeons in Ireland.
    Objective: Diabetic foot ulcers (DFUs) are a significant challenge in wound care practice. Our aim was to evaluate the combined use of of two therapies, ultrasound and electrostimulation, in the treatment of DFUs.

    Method: This study employed a prospective, non-comparative, case series design, undertaken in a podiatry-led diabetic foot clinic, in an acute hospital setting, in an urban location in Ireland. Read More

    A diabetic foot ulcer treated with hydrogel and hyperbaric oxygen therapy: a case study.
    J Wound Care 2017 Nov;26(11):692-695
    Lecturer, Universidade Luterana do Brasil, Rio Grande, Rio Grande do Sul, Brazil.
    This study reports on the case of an elderly patient, with diabetes, and a bullous wound on the left big toe that led to an amputation of the first and second left toes. The amputation was because of deep injury as it was not able to heal with a conventional treatment. After completing the normal treatment and the removal of a bacterial infection in the lesion, the patient underwent a treatment that was based on a hydrogel gel (0. Read More

    Topical oxygen therapy promotes the healing of chronic diabetic foot ulcers: a pilot study.
    J Wound Care 2017 Nov;26(11):652-660
    Consultant Vascular Surgeon, St George's Vascular Unit, St George's Healthcare NHS Trust, Tooting, London, UK.
    Objective: Interventions that can heal or reduce diabetic foot ulcer (DFU) size may reduce the incidence of infection and amputation, and reduce associated social and economic costs. Many chronic wounds exhibit a degree of hypoxia and this leads to a reduction in healing processes including cell division and differentiation, angiogenesis, infection prevention, and collagen production. The aim of this pilot study was to assess the effects of a device supplying continuous oxygen ambulatory therapy on healing in chronic DFUs. Read More

    Analysis: A Step Toward Standardizing Diabetic Foot Images.
    J Diabetes Sci Technol 2017 Nov 1:1932296817740593. Epub 2017 Nov 1.
    1 Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland.
    In this issue of Journal of Diabetes Science and Technology Yap and coauthors report on the design and present results from a reliability study of the application called FootSnap that is intended for standardization of the distance and the orientation of the camera relative to the diabetic foot that is photographed. To produce standardized photographs FootSnap uses a straightforward, yet original and useful method. However, other systems have been reported and clinically tested earlier, in which the same parameters of foot images might be standardized and which are free of some limitations of FootSnap. Read More

    Histomorphological and biochemical properties of plantar soft tissue in diabetes.
    Foot (Edinb) 2017 Dec 7;33:1-6. Epub 2017 Jun 7.
    VA RR&D Center of Excellence for Limb Loss Prevention and Prosthetic Engineering, Seattle, WA 98108, United States; Department of Mechanical Engineering, University of Washington, Seattle, WA 98195, United States; Department of Orthopaedics & Sports Medicine, University of Washington, Seattle, WA 98195, United States.
    Background: Diabetes results in pathophysiological changes, leading to tissue that is unable to withstand and adapt to the same loads, resulting in breakdown. Certain locations are more susceptible to breakdown, yet differences between locations are largely not well understood. The authors performed a histological and biochemical analysis of isolated plantar adipose tissue at six relevant locations. Read More

    Compassionate Use of Bacteriophage Therapy for Foot Ulcer Treatment as an Effective Step for Moving Toward Clinical Trials.
    Methods Mol Biol 2018 ;1693:159-170
    VA Northern California, Muir Road, Martinez, CA, 94553, USA.
    We here present detailed descriptions of successful treatment of a series of diabetic toe ulcers using the Eliava BioPreparations' commercial preparation of the very well-studied anti-staphylococcal bacteriophage Sb-1. This chapter outlines what we feel is an appropriate mechanism to speed movement toward full-scale clinical trials with bacteriophage use to treat wound infections and to help address the crisis in antibiotic resistance. Read More

    Bacteriophage Treatment of Infected Diabetic Foot Ulcers.
    Methods Mol Biol 2018 ;1693:151-158
    Institute of Chemical Biology and Fundamental Medicine SB RAS, Laboratory of Molecular Microbiology, Lavrentiev Ave. 8, Novosibirsk, 630090, Russian Federation.
    Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of infected ulcers is complicated by formation of microbial biofilms , which are often heterogeneous and resistant to antibiotics. Read More

    Comparison of human umbilical cord blood-derived mesenchymal stem cells with healthy fibroblasts on wound-healing activity of diabetic fibroblasts.
    Int Wound J 2017 Nov 7. Epub 2017 Nov 7.
    Department of Plastic Surgery, Korea University College of Medicine, Seoul, South Korea.
    Various types of skin substitutes composed of fibroblasts and/or keratinocytes have been used for the treatment of diabetic ulcers. However, the effects have generally not been very dramatic. Recently, human umbilical cord blood-derived mesenchymal stromal cells (hUCB-MSCs) have been commercialised for cartilage repair as a first cell therapy product using allogeneic stem cells. Read More

    The impact of diabetes on corneal nerve morphology and ocular surface integrity.
    Ocul Surf 2017 Nov 4. Epub 2017 Nov 4.
    School of Optometry & Vision Science, University of New South Wales, Sydney, Australia.
    Diabetes mellitus is a chronic disease that results from inadequate insulin production or ineffective insulin utilization. It is one of the most common systemic diseases worldwide with increasing prevalence. Diabetes mellitus is associated with premature mortality, macrovascular complications such as cardiovascular disease, and microvascular complications, including nephropathy leading to kidney failure, potentially blinding diabetic retinopathy, and diabetic neuropathy. Read More

    Antibiotic Resistance in Diabetic Foot Soft Tissue Infections: A Series From Greece.
    Int J Low Extrem Wounds 2017 Nov 1:1534734617737640. Epub 2017 Nov 1.
    1 Democritus University of Thrace, Alexandroupolis, Greece.
    Diabetic foot infections are a common and serious problem for all health systems worldwide. The aim of this study was to examine the resistance to antibiotics of microorganisms isolated from infected soft tissues of diabetic foot ulcers, using tissue cultures. We included 113 consecutive patients (70 men, 43 women) with a mean age of 66. Read More

    Minimally Invasive Distal Metatarsal Diaphyseal Osteotomy (DMDO) for Chronic Plantar Diabetic Foot Ulcers.
    Foot Ankle Int 2017 Nov 1:1071100717735640. Epub 2017 Nov 1.
    1 Orthopaedic Clinic, Department of Surgery, Oncology and Gastroenterology DiSCOG, University of Padua, Padova, Italy.
    Background: The aims of this prospective study were first to evaluate the safety and effectiveness of minimally invasive distal metatarsal diaphyseal osteotomies (DMDOs) for treating a consecutive series of diabetic patients with chronic plantar diabetic foot ulcers (CPDFUs) and second to assess their clinical-functional and radiographic outcomes.

    Methods: A consecutive series of patients affected by diabetes mellitus with CPDFUs, not responsive to previous nonoperative management, underwent DMDO. The CPDFUs were evaluated using the University of Texas Diabetic Wound Classification System (UTDWC). Read More

    Prevalence of Pressure Ulcer and Nutritional Factors Affecting Wound Closure Success in Thailand.
    Mater Sociomed 2017 Sep;29(3):196-200
    Department of Surgery, Faculty of Medicine, Chiang Mai University, Thailand.
    Introduction: The authors aimed to estimate the prevalence of pressure ulcers and to explore the nutritional effects of the prognostic factors on successful pressure ulcer closure in a public tertiary care hospital in Thailand.

    Patients And Methods: The study was a retrospective cohort analysis of seven-year census (2008 - 2014) at Surin hospital in Thailand. There were 424 of total 240,826 patients aged over than 15 years admitted to surgery, orthopedics and medicine wards during the study period with documented pressure ulcers (ICD 10TM). Read More

    Does non-contact low-frequency ultrasound (NLFU) therapy contribute to wound healing at the molecular level?
    Wound Repair Regen 2017 Nov 2. Epub 2017 Nov 2.
    Center for Wound Healing, South Shore Hospital, Weymouth, MA, USA.
    Non-contact low frequency ultrasound (NLFU) is used to treat various types of chronic wounds including venous, diabetic and pressure ulcers. The objective for this sub study of the IN BALANCE RCT VLU trial was to characterize and compare the NLFU treatment group and patients receiving standard of care (SOC) with respect to the effect of the assigned study treatment on content/quantity of inflammatory cytokines and fibrinogen as well as bacteria. Higher mean wound area reduction was observed in the NLFU treatment group (67. Read More

    The impact of glycaemic variability on wound healing in the diabetic foot - A retrospective study of new ulcers presenting to a specialist multidisciplinary foot clinic.
    Diabetes Res Clin Pract 2017 Oct 31;135:23-29. Epub 2017 Oct 31.
    Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK.
    Aims: Glycaemic variability - the visit-to-visit variation in HbA1c - plays a possible role in the development of micro and macrovascular disease in patients with diabetes. Whether HbA1c variability is a factor determining wound healing in diabetic foot ulcers remains unknown. We aimed to determine whether HbA1c variability is associated with foot ulcer healing time. Read More

    Viability of permanent PMMA spacer with combined free fasciocutaneous tissue transfer for failed charcot reconstruction: A 38 month prospective case report.
    Int J Surg Case Rep 2017 Oct 4;41:174-179. Epub 2017 Oct 4.
    Department of Plastic Surgery, MedStar Georgetown University Hospital, Washington, DC, USA. Electronic address:
    Introduction: Charcot Neuroarthropathy is a complex lower extremity pathology which predisposes the afflicted limb to ulcerations, osteomyelitis, and risk of major amputation. Charcot Neuroarthropathy often requires osseous reconstruction, which can be complicated with osteomyelitis and hardware infection. When soft tissue and osseous deficits must be concomitantly addressed, the use of PMMA spacers can be combined with free tissue transfers. Read More

    Exendin-4, a glucagon-like peptide-1 analogue accelerates healing of chronic gastric ulcer in diabetic rats.
    PLoS One 2017 2;12(11):e0187434. Epub 2017 Nov 2.
    Department of Anesthesiology, Buddhist Tzu-Chi General Hospital, Hualien, Taiwan.
    Background: Diabetes mellitus is an independent risk factor for impaired healing of peptic ulcers, and there are currently no supplementary therapeutics other than the standard antipeptic medicine to improve the ulcer healing in diabetes. This study examined the potential pleiotropic effect of a glucagon-like peptide (Glp)-1 analogue exendin (Ex)-4 on the regeneration of gastric ulcer in streptozotocin-induced diabetic rats.

    Methods And Results: Chronic ulcer was created in rat stomach by submucosal injection of acetic acid and peri-ulcer tissues were analyzed 7 days after operation. Read More

    A Pilot Study to Evaluate the Effects of Perfusion-decellularized Porcine Hepatic-derived Wound Matrix on Difficult-to-heal Diabetic Foot Ulcers.
    Wounds 2017 Oct;29(10):317-323
    Objective: The purpose of this prospective pilot study is to evaluate the effects of a novel perfusion-decellularized porcine hepatic-derived wound matrix (PDPHD-WM) on very difficult-to-heal diabetic foot ulcers (DFUs).

    Materials And Methods: For the intent of this study, a very difficult-to-heal DFU is one with a duration > 3 months despite using at least 1 advanced healing modality. Seven patients were enrolled in the study for a length of 14 weeks, including a 2-week run-in phase of standard-of-care therapy with saline gel and offloading in a CAM walker. Read More

    Updating the Diabetic Foot Treatment Algorithm: Recommendations on Treatment Using Advanced Medicine and Therapies.
    Wounds 2017 Oct 20. Epub 2017 Oct 20.
    Dr. William M. School College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, Center for Lower Extremity Ambulatory Research (CLEAR), North Chicago, IL.
    Objective: Since the last diabetic foot ulcer (DFU) treatment algorithm was published in 2002, new options for diagnostic testing and treatments have been developed. This study seeks to update the DFU treatment algorithm to include new options available in diagnostic testing and treatment.

    Materials And Methods: A computerized literature search of peer-reviewed articles published between January 2003 and January 2016 was conducted using MEDLINE (PubMed), EMBASE, and the Cochrane Library. Read More

    Effect of puerarin on type II diabetes mellitus with orthopaedic footwear.
    Pak J Pharm Sci 2017 Sep;30(5(Special)):1899-1903
    Shanghai Sunshine Rehabilitation Center (Yangzhi Affiliated Rehabilitation Hospital of Tongji University), Shanghai, China.
    In recent years, the antioxidant efficacy of puerarin has been recognized. However, there is less research on Puerarin used in diabetes. This paper analyzes the effect of puerarin on type II diabetes mellitus induced by streptozotocin combined with orthopaedic footwear. Read More

    Prognosis of the infected diabetic foot ulcer: a 12-month prospective observational study.
    Diabet Med 2017 Oct 30. Epub 2017 Oct 30.
    Schoool of Healthcare, University of Leeds, Leeds, UK.
    Aims: To determine clinical outcomes and explore prognostic factors related to ulcer healing in people with a clinically infected diabetic foot ulcer.

    Methods: This multicentre, prospective, observational study reviewed participants' data at 12 months after culture of a diabetic foot ulcer requiring antibiotic therapy. From participants' notes, we obtained information on the incidence of wound healing, ulcer recurrence, lower extremity amputation, lower extremity revascularization and death. Read More

    Absent monofilament sensation in a type 2 diabetic feet.
    London J Prim Care (Abingdon) 2017 Sep 4;9(5):73-76. Epub 2017 Sep 4.
    Department of Acute Medicine & Endocrinology, Watford General Hospital, Watford, UK.
    Neuropathy is a common complication which can affect up to 90% of patients with diabetes mellitus. Asymptomatic neuropathy is a common presentation. We present a case that emphasises the importance of foot screening in people with diabetes. Read More

    Validity and feasibility of the wound-QoL questionnaire on health-related quality of life in chronic wounds.
    Wound Repair Regen 2017 Oct 28. Epub 2017 Oct 28.
    German Center for Health Services Research in Dermatology (CVderm), Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
    Chronic wounds have a major socioeconomic impact due to their frequency, chronicity, and societal costs. Patients experience substantial quality of life (QoL) impairments. The use of questionnaires for a continuous assessment of QoL and resulting interventions to improve the situation of the individual are an important cornerstone of a guideline-based wound care. Read More

    Comparative cost and clinical effectiveness of clostridial collagenase ointment for chronic dermal ulcers.
    J Comp Eff Res 2017 Oct 27. Epub 2017 Oct 27.
    Connecticut Clinical Nursing Associates, LLC, Bristol, CT 06011, USA.
    Chronic dermal ulcers affect approximately 2.4-4.5 million people in the USA and are associated with loss of function, decreased quality of life and significant economic burden. Read More

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