8,565 results match your criteria Diabetic Ulcers


Management of diabetic persons with foot ulceration during COVID-19 health care emergency: effectiveness of a new triage pathway.

Diabetes Res Clin Pract 2020 Jun 1:108245. Epub 2020 Jun 1.

Diabetic Foot Unit, University of Tor Vergata, Rome.

Aim: To define the outcomes of persons with diabetes and foot ulcers (DFUs) managed through a specific triage pathway during the COVID-19 crisis.

Methods: Patients who had an active DFU during the COVID-19 emergency were included. All participants were managed using a specific triage system driven both by ulcer'severity and concomitant co-diseases. Read More

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http://dx.doi.org/10.1016/j.diabres.2020.108245DOI Listing

Mutual inter-regulation between iNOS and TGF-β1: Possible molecular and cellular mechanisms of iNOS in wound healing.

Biochim Biophys Acta Mol Basis Dis 2020 Jun 1:165850. Epub 2020 Jun 1.

Department of Physiology, College of Medicine (QU Health), Qatar University, P.O. Box 2713, Doha, Qatar. Electronic address:

Abnormal wound healing with excessive scarring is a major health problem with socioeconomic and psychological impacts. In human, chronic wounds and scarring are associated with upregulation of the inducible nitric oxide synthase (iNOS). Recently, we have shown physiological regulation of iNOS in wound healing. Read More

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http://dx.doi.org/10.1016/j.bbadis.2020.165850DOI Listing

Approaches to modulate the chronic wound environment using localized nucleic acid delivery.

Adv Wound Care (New Rochelle) 2020 Jun 4. Epub 2020 Jun 4.

Massachusetts Institute of Technology, 2167, Chemical Engineering, Cambridge, Massachusetts, United States.

Significance: Non-healing wounds have been the subject of decades of basic and clinical research. Despite new knowledge about the biology of impaired wound healing, little progress has been made in treating chronic wounds, leaving patients with few therapeutic options. Diabetic ulcers are a particularly common form of non-healing wound. Read More

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http://dx.doi.org/10.1089/wound.2020.1167DOI Listing

Turkish Adaptation of Diabetic Foot Ulcer Scale-Short Form.

Int J Low Extrem Wounds 2020 Jun 3:1534734620921036. Epub 2020 Jun 3.

Ege University, Izmir, Turkey.

The purpose of this study was to evaluate the validity and reliability of the Turkish version of the Diabetic Foot Scale-Short Form (DFS-SF). The study was cross-sectional and conducted between January and October 2019 in a diabetic foot council of a university hospital. A total of 194 diabetic foot patients participated in the study. Read More

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http://dx.doi.org/10.1177/1534734620921036DOI Listing

A comparison of the wound healing process after the application of three dermal substitutes with or without basic fibroblast growth factor impregnation in diabetic mice.

J Plast Reconstr Aesthet Surg 2020 Jan 23. Epub 2020 Jan 23.

Department of Plastic and Reconstructive Surgery, Kansai Medical University, 2-5-1 Shin-machi, Hirakata City, Osaka 573-1010, Japan.

Pelnac Gplus, Integra, and Terudermis are approved artificial dermis products in Japan. Previously, we proved that Pelnac Gplus was able to sustain basic fibroblast growth factor (bFGF) and accelerated wound healing by releasing impregnated bFGF. In this study, we impregnated Pelnac Gplus, Integra, and Terudermis with bFGF and compared the binding activity and wound-healing process. Read More

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http://dx.doi.org/10.1016/j.bjps.2020.01.031DOI Listing
January 2020

Role and effect of vein-transplanted human umbilical cord mesenchymal stem cells in the repair of diabetic foot ulcers in rats.

Acta Biochim Biophys Sin (Shanghai) 2020 Jun 2. Epub 2020 Jun 2.

Department of Interventional Radiology, Affiliated Hospital of Nantong University, Nantong 226001, China.

Diabetic foot ulcer (DFU) is one of diabetic complications, which is frequently present and tormented in diabetes mellitus. Most multipotent mesenchymal stromal cells (MSCs) are capable of immune evasion, providing an allogeneic, ready-to-use, cell product option for therapeutic applications. The beneficial effect of MSCs for the treatment of a variety of traumatic injuries, such as open wounds, has been extensively explored. Read More

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http://dx.doi.org/10.1093/abbs/gmaa039DOI Listing

Adjunctive rifampin therapy for diabetic foot osteomyelitis: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 May;99(22):e20375

Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, P.R. China.

Introduction: The prevalence of diabetes continues to rise around the world. Diabetic foot is a serious complication of diabetes, and diabetic patients with diabetic foot osteomyelitis (DFO) have a fourfold increased risk of amputation, usually indicating death. Therefore, it is particularly important to seek a more effective treatment for DFO. Read More

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http://dx.doi.org/10.1097/MD.0000000000020375DOI Listing

Making the equivocal unequivocal: standardization of clean margins in diabetic foot osteomyelitis.

Clin Diabetes Endocrinol 2020 20;6. Epub 2020 May 20.

Michigan Medicine, Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, 24 Frank Lloyd Wright Drive, Lobby C, Ann Arbor, MI 48106 USA.

Background: The prevalence of diabetes mellitus continues to rise. Diabetic foot ulcers with osteomyelitis are a diabetes-related complication presenting a significant burden to this cohort. A cure to diabetic foot osteomyelitis remains elusive and standard of care has failed to improve outcomes. Read More

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http://dx.doi.org/10.1186/s40842-020-00096-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238583PMC

Type I collagen matrix plus polyhexamethylene biguanide antimicrobial for the treatment of cutaneous wounds.

J Comp Eff Res 2020 Jun 1. Epub 2020 Jun 1.

Sabolinski LLC, Franklin, MA 02038, USA.

Determine the effectiveness of purified native type I collagen matrix plus polyhexamethylene biguanide antimicrobial (PCMP) on cutaneous wounds. A prospective cohort study of 307 patients (67 venous leg ulcers, 62 diabetic foot ulcers, 45 pressure ulcers, 54 postsurgical wounds and 79 other wounds) was conducted. Cox wound closure for PCMP was 73% at week 32. Read More

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http://dx.doi.org/10.2217/cer-2020-0058DOI Listing

Methylene blue mediated antimicrobial photodynamic therapy in clinical human studies: The state of the art.

Photodiagnosis Photodyn Ther 2020 May 27:101828. Epub 2020 May 27.

Postgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho/UNINOVE, 249 Vergueiro Street, Liberdade, São Paulo, SP, 01504-001, Brazil. Electronic address:

Background: The goals of this study were to update the information about aPDT when using methylene blue (MB) for the treatment of human clinical infections of different etiologies, except for dentistry applications, and to investigate the best parameters of MB to achieve this.

Methods: This study was a systematic literature review performed according to the PRISMA guidelines. A literature search was performed for studies with adult human patients (>18 years-old) published in the English, French, Spanish, Portuguese, and Italian languages when using the electronic databases of MEDLINE, Embase, OpenGrey, and LILACS. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101828DOI Listing

Role of Nrf2 in MALAT1/ HIF-1α loop on the regulation of angiogenesis in diabetic foot ulcex.

Free Radic Biol Med 2020 May 27. Epub 2020 May 27.

Department of Biotechnology and SRM Research Institute, SRM Institute of Science and Technology, Kattankulathur, 603 203, Tamil Nadu, India. Electronic address:

Diabetic non healing wounds often result in significant morbidity and mortality. The number of effective targets to detect these wounds are meagre. Slow lymphangiogenesis is one of the complex processes involved in impaired healing of wounds. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2020.05.018DOI Listing
May 2020
5.736 Impact Factor

Systematic review and meta-analysis of mouse models of diabetes-associated ulcers.

BMJ Open Diabetes Res Care 2020 May;8(1)

Queensland Research Centre for Peripheral Vascular Disease, James Cook University, Townsville, Queensland, Australia

Mouse models are frequently used to study diabetes-associated ulcers, however, whether these models accurately simulate impaired wound healing has not been thoroughly investigated. This systematic review aimed to determine whether wound healing is impaired in mouse models of diabetes and assess the quality of the past research. A systematic literature search was performed of publicly available databases to identify original articles examining wound healing in mouse models of diabetes. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-000982DOI Listing

Effects of Hydrogel With Enriched Sodium Alginate in Wounds of Diabetic Patients.

Plast Surg Nurs 2020 Apr/Jun;40(2):110-115

Murilo Antonio Gustinelli Barbosa, MN, is Nurse, Guarulhos University, São Paulo, Brazil. André Oliveira Paggiaro, PhD, is Plastic Surgeon, Guarulhos University, São Paulo, Brazil. Viviane Fernandes de Carvalho, PhD, is Nurse, Guarulhos University, São Paulo, Brazil. César Isaac, PhD, is Plastic Surgeon, São Paulo University, São Paulo, Brazil. Rolf Gemperli, PhD, is Plastic Surgeon, São Paulo University, São Paulo, Brazil.

Objective of this study was to evaluate the efficacy of the autolytic debridement promoted by hydrogel with sodium alginate enriched with fatty acids and vitamins A and E in the healing of foot wounds in diabetic patients. A clinical study was conducted at an outpatient clinic of medical specialties. The sample comprised 8 patients supervised for a 3-month period, from April to July 2017, by means of a clinical history, photographic record, planimetry, and classification of the wound severity by the Pressure Ulcer Scale for Healing (PUSH) system. Read More

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http://dx.doi.org/10.1097/PSN.0000000000000317DOI Listing

[Continuous bedside pressure mapping in a general intensive care unit: a prospective observational study].

Assist Inferm Ric 2020 Jan-Mar;39(1):5-12

. Continuous bedside pressure mapping in a general intensive care unit: a prospective observational study.

Introduction: A continuous bedside pressure mapping device (PMD) can provide real-time feedback of ideal body position to allow off-loading of high-pressure areas to prevent pressure ulcers development. Read More

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http://dx.doi.org/10.1702/3371.33471DOI Listing

Biological characterization of dehydrated amniotic membrane allograft: Mechanisms of action and implications for wound care.

J Biomed Mater Res B Appl Biomater 2020 May 26. Epub 2020 May 26.

J. Crayton Pruitt Family Department of Biomedical Engineering , University of Florida, Gainesville, Florida, USA.

There is a growing clinical demand in the wound care market to treat chronic wounds such as diabetic foot ulcers. Advanced cell and tissue-based products (CTPs) are often used to address challenging chronic wounds where healing has stalled. These products contain active biologics such as growth factors and cytokines as well as structural components that support and stimulate cell growth and assist in tissue regeneration. Read More

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http://dx.doi.org/10.1002/jbm.b.34635DOI Listing

Optimised cushioning in diabetic footwear can significantly enhance their capacity to reduce plantar pressure.

Gait Posture 2020 May 17;79:244-250. Epub 2020 May 17.

Centre for Biomechanics and Rehabilitation Technologies, Staffordshire University, Stoke-on-Trent, United Kingdom; Faculty of Health Sciences, University of Malta, Msida, Malta.

Background: Plantar pressure reduction with the use of cushioning materials play an important role in the clinical management of the diabetic foot. Previous studies in people without diabetes have shown that appropriate selection of the stiffness of such materials can significantly enhance their capacity to reduce pressure. However the significance of optimised cushioning has not been yet assessed for people with diabetic foot syndrome. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.05.009DOI Listing

Complete wound closure following a single topical application of a novel autologous homologous skin construct: first evaluation in an open-label, single-arm feasibility study in diabetic foot ulcers.

Int Wound J 2020 May 26. Epub 2020 May 26.

The Angiogenesis Foundation, Cambridge, Massachusetts, USA.

Diabetic foot ulcers (DFUs) are a growing burden on patients and health care systems that often require multiple treatments of both conventional and advanced modalities to achieve complete wound closure. A novel autologous homologous skin construct (AHSC) has been developed to treat cutaneous defects with a single topical application, by leveraging the endogenous repair capabilities of the patient's healthy skin. The AHSC's ability to close DFUs with a single treatment was evaluated in an open-label, single-arm feasibility study. Read More

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http://dx.doi.org/10.1111/iwj.13404DOI Listing

Exploring MicroRNAs in Diabetic Chronic Cutaneous Ulcers: Regulatory Mechanisms and Therapeutic Potentials.

Br J Pharmacol 2020 May 25. Epub 2020 May 25.

Key Laboratory of Basic Pharmacology of Ministry of Education, China.

Diabetic chronic cutaneous ulcers (DCU) is one of the serious complications of diabetes mellitus, which mainly occurs in diabetic patients with peripheral neuropathy. Recent studies have indicated that microRNAs (miRNAs/miRs) and their target genes are essential regulators of cell physiology and pathology including biological processes that are involved in the regulation of diabetes and diabetes-related microvascular complications. In vivo and in vitro models have revealed that the expression of some miRNAs can be regulated in the inflammatory response, cell proliferation, and wound remodeling of DCU. Read More

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http://dx.doi.org/10.1111/bph.15139DOI Listing

Elderly individuals with diabetes and foot ulcer have a probability for healing despite extensive comorbidity and dependency.

Expert Rev Pharmacoecon Outcomes Res 2020 May 23. Epub 2020 May 23.

Skåne University Hospital , Department of Endocrinology, 214 21 Malmö Sweden.

Background: limited scientific evidence for prevention and treatment of diabetic foot ulcers in elderly with comorbidities.

Aim: explore patient-related factors and outcome in patients ≥75 years with diabetes and a foot ulcer.

Method: sub-analysis of consecutively presenting patients ≥75 years (N=1008) from a previous study on 2,480 patients with diabetes foot ulcer treated in a multidisciplinary system until healing. Read More

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http://dx.doi.org/10.1080/14737167.2020.1773804DOI Listing

The Macrophage Responses during Diabetic Oral Ulcer Healing by Liquid Coconut Shell Smoke: An Immunohistochemical Analysis.

Eur J Dent 2020 May 24. Epub 2020 May 24.

Department of Dental Science, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.

Objectives:  Liquid coconut shell smoke (LC-SS) is used in natural food preservation for a long history. The purpose of this study was to analyze the role of LC-SS in macrophage responses during diabetic oral ulcer healing as medication.

Materials And Methods:  Oral ulcers were induced in the labial lower mucosa of the research subjects using a round steel blade following diabetic induction by means of alloxan. Read More

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http://dx.doi.org/10.1055/s-0040-1712776DOI Listing

NMR-based metabolomic analysis for the effects of Huiyang Shengji extract on rat diabetic skin ulcers.

J Ethnopharmacol 2020 May 19:112978. Epub 2020 May 19.

College of Chemistry and Chemical Engineering, Key Laboratory for Chemical Biology of Fujian Province, MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Xiamen University, Xiamen, 361005, China. Electronic address:

Ethnopharmacological Relevance: Huiyang Shengji formula (HSF) is a compound Chinese herbal medicine prescription, and has long been used for treating chronic non-healing wounds.

Aim Of The Study: The purpose of this study was to elucidate the molecular mechanisms of HSF's healing effects.

Materials And Methods: We established a rat diabetic skin ulcer (DSU) model, and assessed effects of four HSF treatments on DSUs by calculating wound healing rates and immunohistochemical detection of the expressions of angiogenesis-related factors in the model rats (Mod) relative to normal rats (Nor), including Huiyang extract (HE), Shengji extract (SE), Huiyang Shengji extract (HSE) and HSE associated with acupuncture (Ac-HSE). Read More

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http://dx.doi.org/10.1016/j.jep.2020.112978DOI Listing

Dissolved oxygen from microalgae-gel patch promotes chronic wound healing in diabetes.

Sci Adv 2020 May 15;6(20):eaba4311. Epub 2020 May 15.

State Key Laboratory of Pharmaceutical Biotechnology, Medical School and School of Life Sciences, Nanjing University, Nanjing 210093, China.

Chronic wounds in diabetes undergo a lifetime risk of developing into diabetic foot ulcers. Oxygen is crucial to wound healing by regulating cell proliferation, migration, and neovascularization. However, current oxygen therapies, including hyperbaric oxygen (HBO) and topical gaseous oxygen (TGO), mainly employ gaseous oxygen delivery, which is much less effective in penetrating the skin. Read More

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http://dx.doi.org/10.1126/sciadv.aba4311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228761PMC

Inhibition of circulating exosomal microRNA-15a-3p accelerates diabetic wound repair.

Aging (Albany NY) 2020 May 21;12(10):8968-8986. Epub 2020 May 21.

Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Diabetic foot ulcers are a common complication of diabetes, and are usually incurable in the clinic. Exosomes (carriers that transfer endogenous molecules) from diabetic patients' blood have been demonstrated to suppress diabetic wound repair. In this study, we investigated the effects of circulating exosomal microRNA-15a-3p (miR-15a-3p) on diabetic wound repair. Read More

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http://dx.doi.org/10.18632/aging.103143DOI Listing

Prediction of post-interventional physical function in diabetic foot ulcer patients using patient reported outcome measurement information system (PROMIS).

Foot Ankle Surg 2020 May 11. Epub 2020 May 11.

Department of Orthopaedics and Rehabilitation, University of Rochester, United States. Electronic address:

Background: Infected diabetic foot ulcer (DFU) patients present with an impaired baseline physical function (PF) that can be further compromised by surgical intervention to treat the infection. The impact of surgical interventions on Patient Reported Outcomes Measurement Information System (PROMIS) PF within the DFU population has not been investigated. We hypothesize that preoperative PROMIS scores (PF, Pain Interference (PI), Depression) in combination with relevant clinical factors can be utilized to predict postoperative PF in DFU patients. Read More

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http://dx.doi.org/10.1016/j.fas.2020.04.009DOI Listing

Hospitalization costs associated with diabetic foot ulcers treated by a multidisciplinary team in clinical practice. A retrospective study from southern Turkey.

Ann Ital Chir 2020 May 14;9. Epub 2020 May 14.

Purpose: Diabetic foot ulceration (DFU) is a common problem throughout the world and results in major economic consequences for the patients and country. We aim to describe the estimated cost of illness in patients with DFU in southern Turkey.

Methods: A total of 148 (F=55, M=93) patients with DFU were included in this retrospective study. Read More

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KGF-2 and FGF-21 poloxamer 407 hydrogel coordinates inflammation and proliferation homeostasis to enhance wound repair of scalded skin in diabetic rats.

BMJ Open Diabetes Res Care 2020 May;8(1)

Department of Dermatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

Objective: The present study focused on the development of a poloxamer 407 thermosensitive hydrogel loaded with keratinocyte growth factor-2 (KGF-2) and fibroblast growth factor-21 (FGF-21) as a therapeutic biomaterial in a scald-wound model of type-2 diabetes in Goto-Kakizaki (GK) rats.

Research Design And Methods: In this study, a poloxamer 407 thermosensitive hydrogel loaded with KGF-2 and/or FGF-21 was prepared and its physical and biological properties were characterized. The repairing effects of this hydrogel were investigated in a scald-wound model of type-2 diabetes in GK rats. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-001009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245451PMC

Electrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic foot ulcer healing: in vitro and in vivo studies.

Sci Rep 2020 May 20;10(1):8312. Epub 2020 May 20.

Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.

Functional wound dressing with tailored physicochemical and biological properties is vital for diabetic foot ulcer (DFU) treatment. Our main objective in the current study was to fabricate Cellulose Acetate/Gelatin (CA/Gel) electrospun mat loaded with berberine (Beri) as the DFU-specific wound dressing. The wound healing efficacy of the fabricated dressings was evaluated in streptozotocin-induced diabetic rats. Read More

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http://dx.doi.org/10.1038/s41598-020-65268-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239895PMC

Organizational changes in diabetic foot care practices for patients at low and moderate risk after implementing a comprehensive foot care program in Alberta, Canada.

J Foot Ankle Res 2020 May 19;13(1):26. Epub 2020 May 19.

Diabetes, Obesity and Nutrition Strategic Clinical Network, Alberta Health Services, 10101 Southport Road, Calgary, Alberta, T2W 1S7, Canada.

Background: Neuropathy and vasculopathy can lead to costly and debilitating complications in people with diabetes. The purpose of this study was to evaluate, at an organizational level, uptake of practices included in a diabetic foot care clinical pathway and associated resources. This research focused on patients at low and moderate risk in Alberta, Canada between 2014 to 2019. Read More

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http://dx.doi.org/10.1186/s13047-020-00393-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236492PMC

Clinician Assessment Tools for Patients with Diabetic Foot Disease: A Systematic Review.

J Clin Med 2020 May 15;9(5). Epub 2020 May 15.

Department of Physiotherapy, University of Málaga, Arquitecto Francisco Peñalosa, s/n. Ampliación campus de Teatinos, 29071 Málaga, Spain.

The amputation rate in patients with diabetes is 15 to 40 times higher than in patients without diabetes. To avoid major complications, the identification of high-risk in patients with diabetes through early assessment highlights as a crucial action. Clinician assessment tools are scales in which clinical examiners are specifically trained to make a correct judgment based on patient outcomes that helps to identify at-risk patients and monitor the intervention. Read More

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http://dx.doi.org/10.3390/jcm9051487DOI Listing

Stiffness degree of ankle range of motion in diabetic patients with atypical amputation.

Rev Assoc Med Bras (1992) 2020 May;66(2):216-221

. DP Research Group FROG: Cognitive Deterioration and Frailty, Nursing Department, Faculty of Nursing and Podiatry, University of Valencia, 46001 - Valencia, Spain.

Objective: In diabetics, foot deformities are risk factors that increase the risk of amputation as a result of developing ulcers. However, knowledge of the influence of plantar stiffness is still limited. The main objective was to describe connections between the degree of stiffness of the ankle, atypical amputation, and the Foot Posture Index (FPI). Read More

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http://dx.doi.org/10.1590/1806-9282.66.2.216DOI Listing

Diabetic foot ulcer with osteomyelitis.

Authors:
Linda Hicks

J Wound Care 2020 May;29(Sup5b):S27-S29

Advanced Podiatrist, County Durham and Darlington NHS Foundation Trust, Darlington, UK.

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http://dx.doi.org/10.12968/jowc.2020.29.Sup5b.S27DOI Listing

Comparative Microbiological and Whole-Genome Analysis of Populations in the Oro-Nasal Cavities, Skin and Diabetic Foot Ulcers of Patients With Type 2 Diabetes Reveals a Possible Oro-Nasal Reservoir for Ulcer Infection.

Front Microbiol 2020 30;11:748. Epub 2020 Apr 30.

Microbiology Research Unit, Division of Oral Biosciences, Dublin Dental University Hospital, Trinity College Dublin, The University of Dublin, Dublin, Ireland.

Patients with type 2 diabetes are at higher risk for periodontal disease and diabetic foot ulcer infections (DFUIs), the latter of which are predominantly caused by staphylococcal bacteria. Staphylococci have also been detected in the mouth, nose and gums (the oro-nasal cavity) of patients with periodontal disease and can move between the mouth and nose. The present study investigated if the oro-nasal cavity and/or periodontal pockets (PPs) in diseased gum tissue can provide a microbial reservoir for DFUIs. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212350PMC

Characterization of Proangiogenic Monocytes from Blood in Patients with Chronic Ischemic Diabetic Foot Ulcers and Controls.

Stem Cells Dev 2020 May 18. Epub 2020 May 18.

University of Geneva, 27212, Geneva, GE, Switzerland;

Many persons with diabetes mellitus have limb ischemia, which is a major clinical problem. A subset of human monocytes that expresses TIE-2, may enhance neo-vascularization. We performed 179 phlebotomies on 142 patients (or donors), including 61 patients/donors without diabetes or ischemia (controls), 29 39 diabetic non-ischemic patients (controls), and 43 42 diabetic patients with severe limb ischemia requiring amputation. Read More

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http://dx.doi.org/10.1089/scd.2019.0266DOI Listing

Platelet lysate promotes the healing of long-standing diabetic foot ulcers: A report of two cases and study.

Heliyon 2020 May 4;6(5):e03929. Epub 2020 May 4.

Cell Therapy Center, University of Jordan, Amman, Jordan.

Long-standing foot ulcers present a great challenge in diabetes care. Platelet products have been suggested as a possible therapeutic option. However, nor the effect of an injectable form of platelet lysate on the healing of ulcers nor that on primary cells of the epidermis have been studied. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e03929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218073PMC

Management of diabetic foot ulcers: a 25% lidocaine topical cream formulation design, physicochemical and microbiological assessments.

Eur J Hosp Pharm 2020 May 12;27(3):162-167. Epub 2018 Nov 12.

Département de Pharmacie, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, Paris, France.

Background: Given the importance of surgical debridement in healing of diabetic foot ulcers, effective local anaesthesia is required to manage the related extreme pain. The pharmaceutical proprietary products currently available have low concentrations and do not exceed 5% w/w local anaesthetic.

Objective: Formulation design of a lidocaine cream of 25% and assessment of the intrinsic stability. Read More

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http://dx.doi.org/10.1136/ejhpharm-2018-001680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223286PMC

Surgical treatment of diabetic foot ulcers during the COVID-19 pandemic in China.

J Diabetes Complications 2020 May 14:107622. Epub 2020 May 14.

Department of Orthopaedics, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei province, PR China.

Diabetic foot ulcers are among the most serious complications of diabetes. If left untreated, these ulcers can lead to severe infection and gangrene; in some instances, they may result in death. Thus, timely treatment of diabetic foot ulcers is extremely important. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2020.107622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224648PMC

The diabetic foot ulcer.

Aust J Gen Pract 2020 05;49(5):250-255

FRACS (Vasc), Vascular Surgeon, Lismore Base Hospital, NSW.

Background: Diabetic foot ulcers are associated with significant morbidity and mortality and can subsequently lead to hospitalisation and lower limb amputation if not recognised and treated in a timely manner.

Objective: The aim of this article is to review the current evidence for preventing and managing diabetic foot ulcers, with the aim to increase clinicians' confidence in assessing and treating these complex medical presentations.

Discussion: All patients with diabetes should have an annual foot review by a general practitioner or podiatrist. Read More

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http://dx.doi.org/10.31128/AJGP-11-19-5161DOI Listing

Phenotypes and outcomes in middle-aged patients with diabetic foot ulcers: a retrospective cohort study.

J Foot Ankle Res 2020 May 15;13(1):24. Epub 2020 May 15.

Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Although ageing could increase the risk of delayed healing in diabetic foot ulcers (DFUs) patients, data from middle-aged patients remains greatly limited. The purpose of this study was to explore the clinical phenotypes, outcomes and predictive factors of DFU in middle-aged patients.

Methods: A retrospective cohort study conducted with 422 consecutive inpatients with DFUs who visited our hospital between May 2010 and September 2017; participants were recruited and assigned according to age to either the middle-aged group or the elderly group. Read More

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http://dx.doi.org/10.1186/s13047-020-00386-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227070PMC

Elicitation of disease concepts in patients with diabetic foot ulcers: a qualitative study.

J Wound Care 2020 May;29(Sup5a):S38-S45

ICON Clinical Research, South San Francisco, CA, US.

Objective: To identify in-depth information directly from patients with diabetic foot ulcers (DFU) on DFU symptoms, impacts on functioning and effects on health-related quality of life (HRQoL).

Method: Semi-structured, qualitative concept elicitation interviews were conducted with patients with DFUs (Wagner grade 1 or 2) until saturation was reached. Qualitative analysis (using MAXQDA, VERBI GmbH, Germany) of interview transcripts was conducted to identify concepts relevant to patients with DFUs, based on the frequency of mentions, and elucidate themes regarding impacts on HRQoL. Read More

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http://dx.doi.org/10.12968/jowc.2020.29.Sup5a.S38DOI Listing

Silver nanoparticles: Advanced and promising technology in diabetic wound therapy.

Mater Sci Eng C Mater Biol Appl 2020 Jul 11;112:110925. Epub 2020 Apr 11.

School of Pharmacy, Faculty of Health and Medical Science, Taylor's University, Subang Jaya, 47500, Selengor, Malaysia. Electronic address:

Wounds associated with diabetes mellitus are the most severe co-morbidities, which could be progressed to cause cell necrosis leading to amputation. Statistics on the recent status of the diabetic wounds revealed that the disease affects 15% of diabetic patients, where 20% of them undergo amputation of their limb. Conventional therapies are found to be ineffective due to changes in the molecular architecture of the injured area, urging novel deliveries for effective treatment. Read More

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http://dx.doi.org/10.1016/j.msec.2020.110925DOI Listing

Tarsal tunnel release restores sensations in sole for diabetic sensorimotor polyneuropathy.

J Clin Orthop Trauma 2020 May-Jun;11(3):442-447. Epub 2019 Aug 16.

Department of Surgery, NSCB Government Medical College, Jabalpur, MP, 482003, India.

Background: Diabetic sensorimotor polyneuropathy DSPN) is the commonest form of neuropathy. Loss of sensations in sole leads to diabetic foot ulcers (DFU) and its complications. Surgical decompression has been used in the treatment of diabetic peripheral neuropathy, however; its effectiveness has been questioned. Read More

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http://dx.doi.org/10.1016/j.jcot.2019.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211905PMC

Autologous platelet-rich plasma treatment for patients with diabetic foot ulcers: a meta-analysis of randomized studies.

J Diabetes Complications 2020 May 3:107611. Epub 2020 May 3.

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai, China. Electronic address:

Background: This study will explore the effectiveness and safety of autologous PRP in the treatment of patients with DFU.

Methods: The electronic databases of PubMed, EMBASE, BIOSIS, Cochrane central, and Google Scholar internet were searched updated on Jan 30, 2020. Evaluated outcomes included rate of complete ulcer healing, time to healing and adverse events. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2020.107611DOI Listing

Dysregulation of microRNA expression in diabetic skin.

J Dermatol Sci 2020 May 4. Epub 2020 May 4.

Lab. Molecular and Cell Biology, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Via dei Monti di Creta, Rome, Italy. Electronic address:

Background: Clinical skin manifestations are common in diabetes; however, molecular mechanisms underlying such defects are largely unknown. Several findings indicate a role for microRNAs (miRNAs) in skin homeostasis.

Objective: To investigate whether miRNA expression is altered in diabetic skin. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2020.04.009DOI Listing

Compounding Pearls -- Wound Care: Diabetic Foot Ulcers, Part 2.

Authors:
Mike Riepl

Int J Pharm Compd 2020 May-Jun;24(3):182-186

Gateway Pharmacy North, Bismarck, North Dakota.

The often-debilitating ulcers that develop on the feet of patients with diabetes (i.e., "diabetic foot ulcers") are among the most common types of chronic wounds. Read More

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A Systematic Review and Meta-Analysis of the Effects of Low-Level Laser Therapy in the Treatment of Diabetic Foot Ulcers.

Int J Low Extrem Wounds 2020 May 12:1534734620914439. Epub 2020 May 12.

Federal University of Piaui, Piaui, Brazil.

Diabetic foot ulcers (DFUs) are considered one of the most aggressive and expensive complications of diabetes. Low-level laser therapy (LLLT) has been highlighted as a potential modality of treatment to accelerate the healing of ulcers. This systematic review and meta-analysis aimed to investigate the efficacy of LLLT in the treatment of DFU and identify the LLLT application parameters recommended for the treatment of DFU over the past 10 years. Read More

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http://dx.doi.org/10.1177/1534734620914439DOI Listing

Comparison of a new versus standard removable offloading device in patients with neuropathic diabetic foot ulcers: a French national, multicentre, open-label randomized, controlled trial.

BMJ Open Diabetes Res Care 2020 May;8(1)

Department of Endocrinology, Diabetology and Nutrition, CHU Bordeaux, Haut Lévèque Hospital, Pessac, France.

Introduction: The offloading is crucial to heal neuropathic diabetic foot ulcer (DFU). Removable offloading are the most used devices. is a new customized removable knee-high offloading device immobilizing foot and ankle joints, with some specific and innovative features that may improve offloading. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-000954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223015PMC

Facilitators and barriers of using digital technology for the management of diabetic foot ulcers: A qualitative systematic review.

Int Wound J 2020 May 10. Epub 2020 May 10.

Family Medicine and Primary Care, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore.

The use of digital technology has been shown to be effective in managing chronic conditions. Telemedicine and mobile application are two common applications of digital technology in managing diabetic foot ulcers (DFU). The facilitators and barriers of using it for DFU management are yet to be explored. Read More

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http://dx.doi.org/10.1111/iwj.13396DOI Listing
May 2020
2.023 Impact Factor

Temperature- and Pressure-Regulating Insoles for Prevention of Diabetic Foot Ulcers.

J Foot Ankle Surg 2020 May 6. Epub 2020 May 6.

Principal Investigator, Vivonics Inc., Bedford, MA.

Diabetic foot ulcers (DFUs) pose a major threat to the United States healthcare system as well as patients and their families. High ulcer recurrence rates indicate that existing preventive measures are not effective. A new generation of multimodal preventive devices may reduce ulceration and amputation rates. Read More

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http://dx.doi.org/10.1053/j.jfas.2019.05.009DOI Listing
May 2020
0.979 Impact Factor