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    1 OF 129

    Temperature- and pH-sensitive wearable materials for monitoring foot ulcers.
    Int J Nanomedicine 2017 31;12:949-954. Epub 2017 Jan 31.
    Wound Healing Research Unit, Department of Dermatology, University of Pisa.
    Foot ulcers account for 15% of comorbidities associated with diabetes. Presently, no device allows the status of foot ulcers to be continuously monitored when patients are not hospitalized. In this study, we describe a temperature and a pH sensor capable of monitoring diabetic foot and venous leg ulcers developed in the frame of the seventh framework program European Union project SWAN-iCare (smart wearable and autonomous negative pressure device for wound monitoring and therapy). Read More

    Exendin-4 in combination with adipose-derived stem cells promotes angiogenesis and improves diabetic wound healing.
    J Transl Med 2017 Feb 15;15(1):35. Epub 2017 Feb 15.
    College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon, 21936, Republic of Korea.
    Background: Diminished wound healing is a major complication of diabetes mellitus and can lead to foot ulcers. However, there are limited therapeutic methods to treat this condition. Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor agonist, is known to have many beneficial effects on diabetes. Read More

    Overview of the preclinical pharmacological properties of Nigella sativa (black seeds): a complementary drug with historical and clinical significance.
    J Physiol Pharmacol 2016 Dec;67(6):801-817
    Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, Michigan, USA.
    Nigella sativa (N. sativa, black seeds; or sometimes known by many other names such as the blessed seed by the Arabs, black cumin in the Holy Bible, black caraway and Kalonji in South Asia) has been traditionally used for many years not only as a food but also as complementary drug. It is the objective of this communication to review the evidence-based pre-clinical pharmacological actions of N. Read More

    Vitamin K Antagonist Therapy Is a Risk Factor for Ulcer Development and Death Among Dialyzed Patients.
    Ther Apher Dial 2017 Feb 14. Epub 2017 Feb 14.
    Nephrology and Dialysis Unit, University Hospital "Maggiore della Carità", Novara, Italy.
    Peripheral artery disease is a common complication among dialyzed patients. Since Vitamin K antagonists promote metastatic calcifications and these are the main determinants of vascular damage, we investigated their role in the development of lower limb ulcers in dialyzed patients. We retrospectively enrolled 316 dialyzed patients, aged 68 ± 15 years, 65% male, 32% diabetic, 43% with ischemic heart disease and followed them for 36 ± 25 months. Read More

    Tropical diabetic hand syndrome: a case report.
    BMC Res Notes 2017 Feb 13;10(1):94. Epub 2017 Feb 13.
    Health and Human Development Research Group, Douala, Cameroon.
    Background: Tropical diabetic hand syndrome describes a complex hand sepsis affecting patients with diabetes across the tropics and often results from a trivial hand trauma. The clinical presentation of this syndrome is variable and ranges from localised swelling and cellulitis, with or without ulceration of the hand to progressive fulminant hand sepsis, and gangrene affecting the entire limb which may be fatal. Tropical diabetic hand syndrome could lead to permanent disability and death as a result of delay in presentation, late diagnosis and late medical and surgical intervention. Read More

    Efficacy and Safety of Alprostadil in Patients with Peripheral Arterial Occlusive Disease Fontaine Stage IV: Results of a Placebo Controlled Randomised Multicentre Trial (ESPECIAL).
    Eur J Vasc Endovasc Surg 2017 Feb 8. Epub 2017 Feb 8.
    UCB Pharma, Brussels, Belgium.
    Objectives: The aim was to assess the efficacy and safety of alprostadil in patients with peripheral arterial occlusive disease (PAOD) Fontaine Stage IV.

    Methods: This was a multinational, prospective, randomised, double blind, placebo controlled, parallel group trial. Patients with Stage IV PAOD were equally randomised to either 4 weeks of alprostadil treatment twice daily or to placebo treatment twice daily. Read More

    The reality of routine practice: a pooled data analysis on chronic wounds treated with TLC-NOSF wound dressings.
    J Wound Care 2017 Feb;26(Sup2):S4-S15
    Vertical, Paris, France.
    Objective: A number of randomised controlled trials (RCT) have compared control groups with TLC-NOSF dressings (UrgoStart) on chronic wounds. Our aim was to determine whether the clinical trials' results translate into routine management of such wounds, by pooling the data from real-life observational studies.

    Method: Observational studies, conducted in France and Germany, evaluating current practices in patients suffering from non-selected chronic wounds treated with a TLC-NOSF dressing were identified. Read More

    Association between ankle equinus and plantar pressures in people with diabetes. A systematic review and meta-analysis.
    Clin Biomech (Bristol, Avon) 2017 Jan 31;43:8-14. Epub 2017 Jan 31.
    School of Health Sciences, Faculty of Health, University of Newcastle, Australia.
    Background: Diabetes is one of the most common chronic diseases in the world and is associated with a life-time risk of foot ulcer of 12-25%. Diabetes related restriction in ankle joint range of dorsiflexion is proposed to contribute to elevated plantar pressures implicated in the development of foot ulcers.

    Methods: A systematic search of EBSCO Megafile Premier (containing MEDLINE, CINAHL, SPORTSdiscus and Academic Search Complete) and The Cochrane Library was conducted to 23rd November 2016. Read More

    [Ischemic origin of diabetic foot disease. Epidemiology, difficulties of diagnosis, options for prevention and revascularization].
    Orv Hetil 2017 Feb;158(6):203-211
    Angiológia, Szent Imre Egyetemi Oktatókórház Budapest, Tétényi út 12-16., 1115.
    "Diabetic foot" as definition covers a multifactorial clinical condition. According to the recent epidemiological data, the role of lower limb ischemia is getting more influential over other pathological causes, like neuropathy, infections and bone or soft tissue deformity. In diabetes, vascular disease leads to increased risk for leg ulcers and minor or major amputations. Read More

    Prevalence of Sensory Neuropathy in Type 2 Diabetes Mellitus and Its Correlation with Duration of Disease.
    Kathmandu Univ Med J (KUMJ) 2016 Apr-Jun;14(54):120-124
    Department of Cardiology, Kathmandu Medical College Teaching Hospital, Kathmandu, Nepal.
    Background Peripheral neuropathy is one of the most common and distressing late complication of diabetes mellitus. Ignorance of the complications may develop foot ulcers and gangrene requiring amputation. Objective The main objective of this study is to find out the prevalence of sensory neuropathy in type 2 diabetes mellitus and to compare it with the duration of disease. Read More

    The Geriatric Nutritional Risk Index Independently Predicts Mortality in Diabetic Foot Ulcers Patients Undergoing Amputations.
    J Diabetes Res 2017 9;2017:5797194. Epub 2017 Jan 9.
    Department of Endocrinology and Metabolism, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
    Objective. Patients with diabetic foot ulcers undergoing amputations have poor prognosis. Malnutrition usually occurs in this population and is associated with increased risk of mortality. Read More

    A model to estimate cost-savings in diabetic foot ulcer prevention efforts.
    J Diabetes Complications 2017 Jan 21. Epub 2017 Jan 21.
    Southern Arizona Limb Salvage Alliance (SALSA), University of Arizona College of Medicine, Tucson, AZ.
    Background: Sustained efforts at preventing diabetic foot ulcers (DFUs) and subsequent leg amputations are sporadic in most health care systems despite the high costs associated with such complications. We sought to estimate effectiveness targets at which cost-savings (i.e. Read More

    [Has been changed numbers and characteristics of patients with major amputations indicated for the diabetic foot in our department during last decade?]
    Vnitr Lek 2016 ;62(12):969-975
    Introduction: One of the most serious complications of the diabetic foot (DF) is a major amputation, which is associated with poor patient prognosis. The occurrence of major amputations may be influenced by a variety of factors including deep infection caused by resistant pathogens.The aims of our study were to compare the incidence of major amputations in podiatric center, characteristics of amputated patients with the DF and other factors contributing to major amputations in last decade. Read More

    Curcumol Promotes Vascular Endothelial Growth Factor (VEGF)-Mediated Diabetic Wound Healing in Streptozotocin-Induced Hyperglycemic Rats.
    Med Sci Monit 2017 Jan 31;23:555-562. Epub 2017 Jan 31.
    Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China (mainland).
    BACKGROUND Wound healing in chronic diabetic mellitus is mainly associated with the management of angiogenesis. The angiogenic mechanism of vascular endothelial growth factor (VEGF) has been widely studied in the context of diabetic ulcers. The aim of this study was to investigate the wound-healing potential of curcumol in streptozotocin-induced diabetic rats. Read More

    Use of a Dehydrated Amniotic Membrane Allograft in the Treatment of Lower Extremity Wounds: A Retrospective Cohort Study.
    Wounds 2017 Jan 23. Epub 2017 Jan 23.
    West Boca Center for Wound Healing, Boca Raton, FL.
    Injuries to the skin are extensively costly to the health care system. When caused by metabolic and vascular compromise, these injuries are even more foreboding for patients. They can result in chronic inflammation, reduced mobility, and chronic pain. Read More

    Safety and efficacy of intramuscular human placenta-derived mesenchymal stromal-like cells (cenplacel [PDA-002]) in patients who have a diabetic foot ulcer with peripheral arterial disease.
    Int Wound J 2017 Jan 30. Epub 2017 Jan 30.
    Celgene Cellular Therapeutics, Warren, NJ, USA.
    The objective of this study was to examine the safety of cenplacel (PDA-002) in patients with peripheral arterial disease (PAD) and a diabetic foot ulcer (DFU). Cenplacel is a mesenchymal-like cell population derived from full-term human placenta. This phase 1, dose-escalation study investigated cenplacel in diabetic patients with chronic DFUs (Wagner grade 1 or grade 2) and PAD [ankle-brachial index (ABI) >0·5 and ≤0·9], enrolled sequentially into each of four dose cohorts (3 × 10(6) , 10 × 10(6) , 30 × 10(6) and 100 × 10(6) cells; administered intramuscularly on study days 1 and 8 in combination with standard of care). Read More

    IL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db Mice.
    PLoS One 2017 26;12(1):e0170639. Epub 2017 Jan 26.
    Department of Immunology, Genentech, South San Francisco, California, United States of America.
    Diabetic foot ulcers (DFU) are one of the major complications in type II diabetes patients and can result in amputation and morbidity. Although multiple approaches are used clinically to help wound closure, many patients still lack adequate treatment. Here we show that IL-20 subfamily cytokines are upregulated during normal wound healing. Read More

    Effect of systemic insulin treatment on diabetic wound healing.
    Wound Repair Regen 2017 Jan 24. Epub 2017 Jan 24.
    Division of Vascular Surgery, Knight Cardiovascular Institute.
    This study investigates if different diabetic treatment regimens affect diabetic foot ulcer healing. From January 2013 to December 2014, 107 diabetic foot ulcers in 85 patients were followed until wound healing, amputation or development of a nonhealing ulcer at the last follow-up visit. Demographic data, diabetic treatment regimens, presence of peripheral vascular disease, wound characteristics, and outcome were collected. Read More

    Prevention and treatment of diabetic foot ulcers.
    J R Soc Med 2017 Jan 1:141076816688346. Epub 2017 Jan 1.
    1 Diabetes Centre, Aintree University Hospital, Liverpool L9 7AL, UK.
    The rising prevalence of diabetes estimated at 3.6 million people in the UK represents a major public health and socioeconomic burden to our National Health Service. Diabetes and its associated complications are of a growing concern. Read More

    The Effectiveness of Negative Pressure Therapy in Diabetic Foot Ulcers with Elevated Protease Activity: A Case Series.
    Adv Wound Care (New Rochelle) 2017 Jan;6(1):38-42
    Department of Systems Medicine, University of Tor Vergata , Rome, Italy .
    Objective: Despite several works have described the usefulness of negative pressure therapy (NPT) in the treatment of diabetic foot ulcers (DFUs), no studies have reported its ability in the proteases modulation in DFUs. The aim of this work was to evaluate the role of NPT as a protease-modulating treatment in DFUs. Approach: We conducted a prospective study of a series of diabetic patients affected by chronic DFUs. Read More

    Dynamic measurement of surface strain distribution on the foot during walking.
    J Mech Behav Biomed Mater 2016 Dec 18;69:249-256. Epub 2016 Dec 18.
    Department of Mechanical Engineering, Faculty of Science and Technology, Keio University, Yokohama, Japan. Electronic address:
    To clarify the mechanism underlying the development of foot disorders such as diabetic ulcers and deformities, it is important to understand how the foot surface elongates and contracts during gait. Such information is also helpful for improving the prevention and treatment of foot disorders. We therefore measured temporal changes in the strain distribution on the foot surface during human walking. Read More

    Health related quality of life in patients with diabetic foot ulceration - translation and Polish adaptation of Diabetic Foot Ulcer Scale short form.
    Health Qual Life Outcomes 2017 Jan 21;15(1):15. Epub 2017 Jan 21.
    Department of Pharmacoeconomics, Medical University of Warsaw, Żwirki i Wigury 81, 02-091, Warszawa, Poland.
    Objectives: Diabetic foot ulcer (DFU) is a common complication of diabetes and not only an important factor of mortality among patients with diabetes but also decreases the quality of life. The short form of Diabetic Foot Ulcer Scale (DFS-SF) provides comprehensive measurement of the impact of diabetic foot ulcers on patients' health related quality of life (HRQoL). The purpose of this study was to translate DFS-SF into Polish and evaluate its psychometric performance in patients with diabetic foot ulcers. Read More

    Cost-effectiveness of using adjunctive porcine small intestine submucosa tri-layer matrix compared with standard care in managing diabetic foot ulcers in the US.
    J Wound Care 2017 Jan;26(Sup1):S12-S24
    Director, Health Economics, Smith & Nephew Biotherapeutics, Fort Worth, TX, US.
    Objective: To estimate the cost-effectiveness of using tri-layer porcine small intestine submucosa (SIS; Oasis Ultra) as an adjunct to standard care compared with standard care alone in managing diabetic foot ulcers (DFUs) in the US, from the perspective of Medicare.

    Method: A Markov model was constructed to simulate the management of diabetic neuropathic lower extremity ulcers over a period of one year in the US. The model was used to estimate the cost-effectiveness of initially using adjunctive SIS compared with standard care alone to treat a DFU in the US at 2016 prices. Read More

    Clinic visit frequency in wound care matters: data from the US wound registry.
    J Wound Care 2017 Jan;26(Sup1):S4-S10
    U.S. Wound Registry, The Woodlands, TX, US.
    Objective: A previous study suggested that the frequency with which patients visit wound care clinics influences the rate of chronic wound healing but high bias was present with regard to wound care centre selection. The objective of this retrospective cohort study was to confirm this finding by using a very large sample size of diabetic foot ulcers (DFUs) from the US Wound Registry.

    Method: Patients who visited the clinic more than once for a new DFU were eligible for study inclusion. Read More

    Indicators of prognosis for admissions from a specialist diabetic foot clinic: a retrospective service improvement exercise.
    J Wound Care 2017 Jan;26(1):40-45
    Diabetic Foot Clinic, Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
    Objective: To look at haematological and biochemical variables as predictors of outcomes in people admitted to hospital with a diabetic foot ulcer (DFU) without the use of technology or devices. In particular, to see if there was a relationship between admission blood cell and protein levels, and the likelihood of angioplasty, amputation, and death at one year after admission.

    Method: A five-year retrospective analysis of patients admitted to a tertiary multidisciplinary specialist diabetic foot clinic looking at admission C-reactive protein (CRP), white cell count (WCC), neutrophil count and HbA1c and their relationship to likelihood of angioplasty, minor or major amputation, and death at one year after admission. Read More

    Diabetic Foot Infections: an Update in Diagnosis and Management.
    Curr Diab Rep 2017 Jan;17(1)
    First Department of Propaedeutic Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 33 Lakonias Street, 115 27, Athens, Greece.
    Foot infections are a common problem in patients with diabetes and a risk factor for limb amputation. They occur as a result of skin ulceration, which facilitates penetration of pathogens to deeper tissues. The diagnosis of infection is clinical. Read More

    Conditions for success in introducing telemedicine in diabetes foot care: a qualitative inquiry.
    BMC Nurs 2017 13;16. Epub 2017 Jan 13.
    Faculty of Health and Social Science, Centre for Evidence-Based Practice, Bergen University College, Bergen, Norway ; Department of Nursing Science, Institute of Health and Society, University of Oslo, Oslo, Norway.
    Background: The uptake of various telehealth technologies to deliver health care services at a distance is expanding; however more knowledge is needed to help understand vital components for success in using telehealth in different work settings. This study was part of a larger trial designed to investigate the effect of an interactive telemedicine platform. The platform consisted of a web based ulcer record linked to a mobile phone to provide care for people with diabetic foot ulcers in outpatient clinics in specialist hospital care in collaboration with primary health care. Read More

    Bio-Engineering tissue and V.A.C. therapy: A new method for the treatment of extensive necrotizing infection in the diabetic foot.
    Ann Ital Chir 2016 Dec 6;87. Epub 2016 Dec 6.
    Aim: The aim of the study is to compare the standard care for progressive necrotizing infection in diabetic foot with a treatment protocol based on the association between autologous fibroblast grafts and vacuum-assisted closure therapy (V.A.C. Read More

    Radiomitigation and Tissue Repair Activity of Systemically Administered Therapeutic Peptide TP508 Is Enhanced by PEGylation.
    AAPS J 2017 Jan 17. Epub 2017 Jan 17.
    Department of Biochemistry and Molecular Biology, The University of Texas Medical Branch, 301 University Blvd., Galveston, Texas, 77555, USA.
    TP508 is a synthetically derived tissue repair peptide that has previously demonstrated safety and potential efficacy in phase I/II clinical trials for the treatment of diabetic foot ulcers. Recent studies show that a single injection of TP508 administered 24 h after irradiation significantly increases survival and delays mortality in murine models of acute radiation mortality. Thus, TP508 is being developed as a potential nuclear countermeasure. Read More

    Biomaterials: A potential pathway to healing chronic wounds?
    Exp Dermatol 2017 Jan 17. Epub 2017 Jan 17.
    Department of Bioengineering, Imperial College London, London, UK.
    Chronic dermal wounds are a devastating problem, which disproportionally affect individuals with conditions such as diabetes, paralysis, or simply old age. These wounds are extremely challenging to treat due to a heterogeneous combination of causative factors, creating a substantial burden on healthcare systems worldwide. Despite their large impact, there is currently a startling lack of options for effectively treating the underlying biological changes that occur within the wounds. Read More

    The Abnormal Architecture of Healed Diabetic Ulcers is the Result of FAK Degradation by Calpain 1.
    J Invest Dermatol 2017 Jan 9. Epub 2017 Jan 9.
    Department of Surgery, Stanford University School of Medicine, Stanford, California, 94305, USA. Electronic address:
    Delayed wound healing is a major complication of diabetes occurring in about 15% of chronic diabetic patients. It not only significantly affects patients' quality of life but also poses a major economic burden to the healthcare system. Most efforts have been focused on accelerating wound re-epithelialization and closure. Read More

    Use of Multiple Adjunctive Negative Pressure Wound Therapy Modalities to Manage Diabetic Lower-Extremity Wounds.
    Eplasty 2016 20;16:e34. Epub 2016 Dec 20.
    Cleveland Clinic Akron General Wound Center, Akron, Ohio.
    Objective: Various treatment options exist for wound healing; however, clinical assessment of the patient and the wound environment must be considered before determining an optimal wound treatment plan. Negative pressure wound therapy alone and/or with an instilled topical solution can be effective in adjunctive management of acute and chronic wounds. Hyperbaric oxygen therapy has also been shown to contribute to the wound-healing process. Read More

    Utilizing the VeraFlo™ Instillation Negative Pressure Wound Therapy System with Advanced Care for a Case Study.
    Cureus 2016 Nov 30;8(11):e903. Epub 2016 Nov 30.
    Advanced Wound Healing Center, Jackson Purchase Medical Center.
    Background:  Mankind has always suffered wounds throughout time due to trauma, disease, and lifestyles. Many wounds are non-healing and have continued to be challenging. However, utilizing advanced wound care treatments, such as negative pressure wound treatment with instillation and dwell time (NPWTi-d), has proven beneficial. Read More

    Arterial stiffness, endothelial and cognitive function in subjects with type 2 diabetes in accordance with absence or presence of diabetic foot syndrome.
    Cardiovasc Diabetol 2017 Jan 6;16(1). Epub 2017 Jan 6.
    Dipartimento Biomedico di Medicina Interna e Specialistica (Di.Bi.M.I.S), University of Palermo, Palermo, Italy.
    Background: Endothelial dysfunction is an early marker of cardiovascular disease so endothelial and arterial stiffness indexes are good indicators of vascular health. We aimed to assess whether the presence of diabetic foot is associated with arterial stiffness and endothelial function impairment.

    Methods: We studied 50 subjects with type 2 diabetes mellitus and diabetic foot syndrome (DFS) compared to 50 diabetic subjects without diabetic foot, and 53 patients without diabetes mellitus, by means of the mini mental state examination (MMSE) administered to evaluate cognitive performance. Read More

    Descriptive, Longitudinal Study Results Applied to Statistical Models to Assess the Impact of Early Microbiological Cultures on the Economic Burden of Treatment for Infected Diabetic Foot Ulcers at a Mexican Public Health Facility.
    Ostomy Wound Manage 2016 Dec;62(12):14-28
    CUCEA, UdG.
    Infection plays a critical role in health care and impacts the cost of the treatment of diabetic foot ulcers (DFU). To examine the cost reduction associated with the multidisciplinary treatment of infected DFU (IDFU) by obtaining early (ie, within 48 hours of admission) microbiological culture results, a descriptive, longitudinal study was conducted. Data were collected prospectively from patient medical charts of a cohort of 67 patients (mean age, 56. Read More

    A Simple Mathematical Model for Wound Closure Evaluation.
    J Am Coll Clin Wound Spec 2015 Dec 29;7(1-3):40-49. Epub 2016 Jul 29.
    Departamento de Ciencias & Tecnologías Farmacéuticas, Universidad de Chile, Santiago, Chile.
    The incidence of ulcers associated to type 2 diabetes mellitus (T2DM) increases every year. We introduce and explore a new mathematical algorithm to evaluate wound-healing in foot ulcers associated to T2DM. Fifteen patients (nine women and six men), mean age of 70 ± 16 years were included. Read More

    Prosthetic restoration in patient with incomplete spinal cord injury.
    Spinal Cord Ser Cases 2016 7;2:15031. Epub 2016 Jan 7.
    Department of Rehabilitation Medicine, Faculty of Medicine, University of Malaya , Kuala Lumpur, Malaysia.
    We describe a case of 55-years-old man with a known T11 AIS C since 1985. The muscle strength of his left leg is better than the right leg and he is an active community ambulator. He walks using his right knee ankle foot orthosis without a knee lock. Read More

    Observation of clinical efficacy of rt-PA intravenous thrombolytic treatment for patients combined with grade 0-1 diabetic foot by Wagner classification and acute ischemic stroke.
    Eur Rev Med Pharmacol Sci 2016 Dec;20(24):5168-5173
    School of Medicine, Nankai University, Tianjin, P.R. China.
    Objective: To evaluate the safety and efficacy of rt-PA intravenous thrombolytic treatment for patients with diabetic foot (DF) and acute ischemic stroke.

    Patients And Methods: A retrospective analysis was performed on 76 patients admitted between June 2012 to December 2015 presenting with acute ischemic stroke and Grade 0-1 DF a (Wagner classification). The treatment group consisted of 44 patients who received rt-PA intravenous thrombolytic treatment, while 32 cases in the control group did not. Read More

    Shear Stress-Normal Stress (Pressure) Ratio Decides Forming Callus in Patients with Diabetic Neuropathy.
    J Diabetes Res 2016 5;2016:3157123. Epub 2016 Dec 5.
    Department of Life Support Technology (Molten), Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
    Aim. Callus is a risk factor, leading to severe diabetic foot ulcer; thus, prevention of callus formation is important. However, normal stress (pressure) and shear stress associated with callus have not been clarified. Read More

    An Alteration of Lymphocytes Subpopulations and Immunoglobulins Levels in Patients with Diabetic Foot Ulcers Infected Particularly by Resistant Pathogens.
    J Diabetes Res 2016 5;2016:2356870. Epub 2016 Dec 5.
    Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
    The aim of our study was to analyse immune abnormalities in patients with chronic infected diabetic foot ulcers (DFUs) especially those infected by resistant microorganisms. Methods. 68 patients treated in our foot clinic for infected chronic DFUs with 34 matched diabetic controls were studied. Read More

    Fibrinogen: A Marker in Predicting Diabetic Foot Ulcer Severity.
    J Diabetes Res 2016 1;2016:2358321. Epub 2016 Dec 1.
    Department of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.
    Aims. To examine whether fibrinogen levels are a valuable biomarker for assessing disease severity and monitoring disease progression in patients with diabetic foot ulcer (DFU). Methods. Read More

    [Meta-analysis on the clinical effects of allogenic acellular dermal matrix treatment for diabetic foot ulcer].
    Zhonghua Shao Shang Za Zhi 2016 Dec;32(12):725-729
    The First Clinical Medical School of Ji'nan University, Guangzhou 510630, China.
    Objective: To analyze the clinical effects of allogenic acellular dermal matrix (ADM) treatment for diabetic foot ulcer (DFU) with meta-analysis. Methods: Databases including PubMed, Cochrance Library, Embase, and OVID EBM Reviews were searched using key words " diabetic foot, diabetic ulcer, diabetic wound, acellular dermal matrix, acellular dermal regenerative tissue matrix, acellular regenerative tissue matrix, AlloDerm, SureDerm, KaroDerm, Graftjacket, Hyalomatrix PA, and Hyalograft 3D" , and Chinese Biological Abstracts, Chinese Journals Full-text Database, VIP Database, and Wanfang Database were searched using key words in Chinese version ",,," to obtain the published trials of allogenic ADM treatment for DFU from January 1990 to July 2015, and then meta-analysis was used to analyze the trials. The measurement indexes were wound contraction rate, wound healing rate, complete epithelization time of wound, and complication rate. Read More

    Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model.
    Theranostics 2017 1;7(1):81-96. Epub 2017 Jan 1.
    Institute of Microsurgery on Extremities, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China;; Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China.
    Chronic wounds have become an economic, social, and public health burden and need advanced treatment. Platelet-rich plasma (PRP) has been used extensively in treatment of chronic wounds because it contains an abundance of growth factors secreted by platelets. The exosomes derived from PRP (PRP-Exos) have been proven to encapsulate principal growth factors from platelets. Read More

    Outcome after protected full weightbearing treatment in an orthopedic device in diabetic neuropathic arthropathy (Charcot arthropathy): a comparison of unilaterally and bilaterally affected patients.
    BMC Musculoskelet Disord 2016 Dec 29;17(1):504. Epub 2016 Dec 29.
    Department of Orthopedics, University of Zürich, Balgrist University Hospital, Zürich, Switzerland.
    Background: Charcot neuropathic arthropathy (CN) is a chronic, progressive, destructive, non-infectious process that most frequently affects the bone architecture of the foot in patients with sensory neuropathy. We evaluated the outcome of protected weightbearing treatment of CN in unilaterally and bilaterally affected patients and secondarily compared outcomes in protected versus unprotected weightbearing treatment.

    Methods: Patient records and radiographs from 2002 to 2012 were retrospectively analyzed. Read More

    New horizons in the understanding of the causes and management of diabetic foot disease: report from the 2017 Diabetes UK Annual Professional Conference Symposium.
    Diabet Med 2017 Mar 23;34(3):305-315. Epub 2017 Jan 23.
    Elsie Bertram Diabetes Centre, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
    Diabetes-related foot disease remains a common problem. For wounds, classic teaching recommends the treatment of any infection, offloading the wound and ensuring a good blood supply, as well as ensuring that the other modifiable risk factors are addressed and optimized. There remain, however, several questions about these and other aspects of the care of diabetes-related foot disease. Read More

    Delay between Onset of Symptoms and Seeking Physician Intervention Increases Risk of Diabetic Foot Complications: Results of a Cross-Sectional Population-Based Survey.
    J Diabetes Res 2016 29;2016:1567405. Epub 2016 Nov 29.
    Department of Medical Informatics and Biostatistics, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, 6 Pasteur Street, 400349 Cluj-Napoca, Romania.
    We present a post hoc analysis of 17,530 questionnaires collected as part of the 2012 screening for neuropathy using Norfolk Quality of Life tool in patients with diabetes in Romania, to assess the impact on foot complications of time between the onset of symptoms of diabetes/its complications and the physician visit. Odds ratios (ORs) for self-reporting neuropathy increased from 1.16 (95% CI: 1. Read More

    Invasive Systemic Infection After Hospital Treatment for Diabetic Foot Ulcer: Risk of Occurrence and Effect on Survival.
    Clin Infect Dis 2017 Feb 10;64(3):326-334. Epub 2016 Nov 10.
    Division of Infectious Diseases, Department of Medicine, and
    Background: Diabetic foot ulcers (DFUs) threaten limbs and prompt hospitalization. After hospitalization, remote-site invasive systemic infection related to DFU (DFU-ISI) may occur. The characteristics of DFU-ISIs and their effect on mortality risk have not been defined. Read More

    Clinical Usage and Economic Effectiveness of a Recently Developed Epidermal Autograft Harvesting System in 13 Chronic Wound Patients in a University-Based Wound Center.
    Cureus 2016 Nov 14;8(11):e878. Epub 2016 Nov 14.
    Division of Acute Care Surgery, University of Missouri, Columbia, Missouri.
    Introduction:  Chronic wounds are a significant healthcare problem in the United States. Their costs approach 25 billion dollars in the United States. Current wound-care treatments of local wound care, moist dressings, and source control, while necessary for wound healing, are frequently not enough to ensure complete wound closure. Read More

    The Role of Connexins in Wound Healing and Repair: Novel Therapeutic Approaches.
    Front Physiol 2016 6;7:596. Epub 2016 Dec 6.
    Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong KongHong Kong, Hong Kong; Faculty of Medicine, Li Ka Shing Institute of Health Sciences, Chinese University of Hong KongHong Kong, Hong Kong.
    Gap junctions are intercellular proteins responsible for mediating both electrical and biochemical coupling through the exchange of ions, second messengers and small metabolites. They consist of two connexons, with (one) connexon supplied by each cell. A connexon is a hexamer of connexins and currently more than 20 connexin isoforms have been described in the literature thus far. Read More

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