Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes: A Case Report.
JBJS Case Connect 2018 Feb 14. Epub 2018 Feb 14.
Center for Musculoskeletal Research (K.L.d.M.B., A.M., E.M.S., and I.O.) and Departments of Pathology and Laboratory Medicine (K.L.d.M.B. and E.M.S.) and Orthopaedics (K.L.d.M.B., A.M., E.M.S., and I.O.), University of Rochester School of Medicine and Dentistry, Rochester, New York.
Case: A patient presenting with an infected diabetic foot ulcer and Staphylococcus aureus chronic osteomyelitis was studied to validate the clinical importance of bacterial colonization of osteocytic-canalicular networks, as we recently reported in a mouse model. We utilized transmission electron microscopy to describe the deformation of S. aureus, from round cocci to rod-shaped bacteria, in the submicron osteocytic-canalicular networks of amputated bone tissue. Read More