Search our Database of Scientific Publications and Authors

I’m looking for a

    7020 results match your criteria Diabetic Ulcers

    1 OF 141

    Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes: A Case Report.
    JBJS Case Connect 2018 Feb 14. Epub 2018 Feb 14.
    Center for Musculoskeletal Research (K.L.d.M.B., A.M., E.M.S., and I.O.) and Departments of Pathology and Laboratory Medicine (K.L.d.M.B. and E.M.S.) and Orthopaedics (K.L.d.M.B., A.M., E.M.S., and I.O.), University of Rochester School of Medicine and Dentistry, Rochester, New York.
    Case: A patient presenting with an infected diabetic foot ulcer and Staphylococcus aureus chronic osteomyelitis was studied to validate the clinical importance of bacterial colonization of osteocytic-canalicular networks, as we recently reported in a mouse model. We utilized transmission electron microscopy to describe the deformation of S. aureus, from round cocci to rod-shaped bacteria, in the submicron osteocytic-canalicular networks of amputated bone tissue. Read More

    Specific PKC β II Inhibitor: One Stone Two Birds in the Treatment of Diabetic Foot Ulcers.
    Biosci Rep 2018 Feb 12. Epub 2018 Feb 12.
    epartment of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China
    To explore whether or not inhibition of protein kinase C beta II (PKC βII) stimulates angiogenesis as well as prevents excessive NETosis in diabetics thus accelerating wound healing.Streptozotocin (STZ, 60 mg/kg/d × 5 d, i.p. Read More

    Limb- and Person-Level Risk Factors for Lower-Limb Amputation in the Prospective Seattle Diabetic Foot Study.
    Diabetes Care 2018 Feb 8. Epub 2018 Feb 8.
    VA Puget Sound Health Care System - Seattle Division, Seattle, WA.
    Objective: Diabetes is the leading cause of nontraumatic lower-limb amputations in the U.S., but no research has prospectively examined associations between limb-specific measurements and amputation risk among patients without foot ulcer. Read More

    Topical 5% potassium permanganate solution accelerates the healing process in chronic diabetic foot ulcers.
    Biomed Rep 2018 Feb 2;8(2):156-159. Epub 2018 Jan 2.
    Department of Research, Cancerology State Institute, Colima State Health Services, Colima 28085, Mexico.
    Potassium permanganate has been reported to be an effective treatment for certain types of wounds. The aim of the present study was to evaluate the use of potassium permanganate in the treatment of diabetic foot ulcers. A single-blind, randomized, controlled clinical trial was conducted on patients with type 2 diabetes mellitus that presented with a foot ulcer persisting for >3 months. Read More

    Collateral circulation between angiosomes in the feet of diabetic patients.
    Vascular 2018 Jan 1:1708538118759250. Epub 2018 Jan 1.
    2 Department of Radiology, Namik Kemal University, Tekirdağ, Turkey.
    Objectives The main factor in the healing of foot ulcers in diabetic patients is adequate perfusion. There is no consensus on whether direct or indirect revascularization is more effective in leg revascularization. At the centre of that debate, there is a disagreement about whether collateral circulation is sufficient or not. Read More

    Slow to heel: a literature review on the management of diabetic calcaneal ulceration.
    Int Wound J 2018 Feb 12. Epub 2018 Feb 12.
    Department of Vascular and Endovascular Surgery, Sir Charles Gairdner Hospital, Perth, WA, Australia.
    The diabetic heel ulcer (DHU) represents a reconstructive challenge to clinicians and the multidisciplinary team alike. It is traditionally viewed as a condition that is inherently difficult to treat due to the intrinsic anatomical vulnerabilities of the heel. In addition to this, several factors are associated with poorer end outcomes - namely, that of major amputation. Read More

    Reconstruction of the plantar toe with a distal reverse instep sensory island flap.
    Microsurgery 2018 Feb 10. Epub 2018 Feb 10.
    Department of general surgery, Shahid Beheshti University of Medical Science, College of medicine, Emam Hosein Hospital, Tehran, Iran.
    Background: Plantar toe ulcers are a challenging surgical problem. There are several methods for reconstruction, but no attention has been given to the preservation of sensation. This report proposes a method to provide protective sensation for the reconstructed area. Read More

    Could essential oils enhance biopolymers performance for wound healing? A systematic review.
    Phytomedicine 2018 Jan 28;38:57-65. Epub 2017 Oct 28.
    Lab3Bio (Laboratorio de Biomateriales, Biomecánica y Bioinstrumentación), Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín, 25 de Mayo 1143, B1650HMK General San Martín, Provincia de Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, C1425FQB CABA, Argentina.
    Background: Millions of people in the world suffer from chronic wounds of different etiologies such as diabetic foot and leg ulcers, without solutions nowadays. Molecules obtained from plants offer an alternative to aid wound healing. Strong evidence about essential oils (EO) anti-inflammatory and antimicrobial properties is thoroughly described in literature and their chemical compositions are well characterized. Read More

    Micrografting chronic lower extremity ulcers with mechanically disaggregated skin using a micrograft preparation system.
    J Wound Care 2018 Feb;27(2):60-65
    Vascular Surgeon, Clinica N. Annunziatella - Rome, Italy.
    Objective: The Rigenera system is a new standardised micrograft preparation system. It works by means of automated mechanical disaggregation of small tissue samples, extracting only the smallest cells (<50µm). The aim of this study was to retrospectively evaluate patients affected by chronic ulcers and who were treated with the micrograft preparation method. Read More

    Calcium alginate-based antimicrobial film dressings for potential healing of infected foot ulcers.
    Ther Deliv 2018 Feb;9(3):185-204
    Department of Pharmaceutical, Chemical & Environmental Sciences, Faculty of Engineering & Science, University of Greenwich, Medway, Central Ave Chatham Maritime, Kent, ME4 4TB, UK.
    Aim: Diabetic foot ulcers are susceptible to infection and nonmedicated dressings are ineffective because they have no antimicrobial activity. This study aimed to develop antimicrobial films to deliver ciprofloxacin for treating bacterial infection. Results/methodology: Ciprofloxacin-loaded calcium alginate films were characterized for porosity, swelling, equilibrium water content, water absorption, water vapor transmission, evaporative water loss, moisture content, mechanical strength, adhesion, IR spectroscopy, scanning electron microscopy, x-ray diffraction, drug release, cytotoxicity and antimicrobial activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Read More

    Establishment of pressurized-liquid extraction by response surface methodology approach coupled to HPLC-DAD-TOF-MS for the determination of phenolic compounds of myrtle leaves.
    Anal Bioanal Chem 2018 Feb 9. Epub 2018 Feb 9.
    Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avd. Fuentenueva s/n, 18071, Granada, Spain.
    Myrtus communis L. (myrtle) is native to the Mediterranean region and Western Asia. Its leaves have demonstrated its potential effect towards different bioactivities like anti-diabetic, anti-diarrheic, anti-ulcer, anti-cancer, among others. Read More

    Role of plasma growth factor in the healing of chronic ulcers of the lower legs and foot due to ischaemia in diabetic patients.
    Postepy Dermatol Alergol 2017 Dec 31;34(6):601-606. Epub 2017 Dec 31.
    Department of Pathomorphology, Mazovian Bródno Hospital, Warsaw, Poland.
    Introduction: It has been demonstrated that plasma growth factor (PGF) responsible for proliferation of smooth muscle cells and fibroblasts significantly shortens treatment duration.

    Aim: To determine the role of human growth factor in the healing of ulcers due to ischaemic diabetic foot syndrome (DFS) following previous angioplasty of the blood vessels of the lower leg and foot.

    Material And Methods: The study group included 50 patients with ischaemic diabetic foot complicated by lower leg ulcers in which angioplasty of the stenotic arteries in the distal lower leg and foot was performed. Read More

    A case report of Tubo-ovarian abscess caused by Burkholderia pseudomallei.
    BMC Infect Dis 2018 02 8;18(1):73. Epub 2018 Feb 8.
    Division of Infectious Disease, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand.
    Background: Melioidosis, the disease caused by Burkholderia pseudomallei is endemic in the Northeastern part of Thailand, South-East Asia, and Northern Australia. The pelvic involvement of disease is rare even in an endemic area. Therefore, we describe in this report the clinical presentation, management, and outcome of the patient with primary tubo-ovarian abscess due to melioidosis. Read More

    Biological effects of amniotic membrane on diabetic foot wounds: a systematic review.
    J Wound Care 2018 Feb;27(Sup2):S19-S25
    Plastic Surgery, Professor, São Paulo University, Brazil.
    Objective: The amniotic membrane has biological properties that are beneficial to the wound healing process of diabetic foot ulcers (DFU). Our aim is to analyse the scientific evidence found in literature on the use of the amniotic membrane to stimulate DFU healing.

    Method: A systematic review of amniotic membrane's influence was undertaken, using the search terms 'placenta' 'diabetic foot' 'amnion' and biological dressing', assessing the outcomes 'wound healing' and 'wound healing time', in DFU. Read More

    The abrupt temperature changes in the plantar skin thermogram of the diabetic patient: looking in to prevent the insidious ulcers.
    Diabet Foot Ankle 2018 30;9(1):1430950. Epub 2018 Jan 30.
    Optics - Biomedicine, INAOE, Puebla, Mexico.
    One of the complications of the diabetes mellitus is the amputation of the lower limbs. This complication may be developed after an insidious ulcer, that may be raised by the peripheral neuropathy or the ischaemic limb, and that the ulcer get infected. That is, to develop an ulcer, in the diabetic patient, three factors should be taken into the account, the autonomic nervous system, the blood supply and the inmune system. Read More

    Correction of ankle and hind foot deformity in Charcot neuroarthropathy using a retrograde hind foot nail-The Kings' Experience.
    Foot Ankle Surg 2017 Apr 28. Epub 2017 Apr 28.
    Diabetic Foot Unit, Kings College Hospital NHS Foundation Trust, United Kingdom.
    Background: Corrective fusion for the unstable deformed hind foot and mid foot in Charcot Neuroarthropathy (CN) is quite challenging and is best done in tertiary centres under the supervision of multidisciplinary teams.

    Methods: We present a follow up to our initial report with a series of 42 hind foot corrections in 40 patients from a tertiary level teaching hospital in the United Kingdom. The mean patient age was 59 (33-82). Read More

    Topical application of Hydroxysafflor Yellow A accelerates the wound healing in streptozotocin induced T1DM rats.
    Eur J Pharmacol 2018 Mar 4;823:72-78. Epub 2018 Feb 4.
    Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, Zhejiang, PR China; Jiangsu Engineering Research Center for New-Type External and Transdermal Preparations, PR China. Electronic address:
    To investigate the effects of Hydroxysafflor Yellow A (HSYA), which is derived from safflower, on the proliferation, migration and angiogenesis of cells in vitro and its potential efficacy in vivo when topically applied to a diabetic wound. Human umbilical vein endothelial cells (HUVECs) and mouse macrophage cells (RAW264.7) were used to evaluate angiogenesis and anti-inflammatory activities, respectively. Read More

    Extranodal natural killer/T-cell lymphoma masquerading a diabetic foot ulcer.
    Diabetes Res Clin Pract 2018 Feb 2;137:208-212. Epub 2018 Feb 2.
    Department of Endocrinology, Air Force General Hospital of P.L.A, China. Electronic address:
    Foot ulcers are among the most frequently recognized complications of diabetes. It's easy to misdiagnose ulcers secondary to malignancy as diabetic foot ulceration because of the clinical similarity. Here we present a case of extranodal natural killer/T-cell lymphoma initially presented as a diabetic foot ulcer. Read More

    Copper Metal-Organic Framework Nanoparticles Stabilized with Folic Acid Improve Wound Healing in Diabetes.
    ACS Nano 2018 Feb 12. Epub 2018 Feb 12.
    Biomedical Engineering Department, Northwestern University , 2145 Sheridan Road, Evanston, Illinois 60208, United States.
    The successful treatment of chronic nonhealing wounds requires strategies that promote angiogenesis, collagen deposition, and re-epithelialization of the wound. Copper ions have been reported to stimulate angiogenesis; however, several applications of copper salts or oxides to the wound bed are required, leading to variable outcomes and raising toxicity concerns. We hypothesized that copper-based metal-organic framework nanoparticles (Cu-MOF NPs), referred to as HKUST-1, which are rapidly degraded in protein solutions, can be modified to slowly release Cu, resulting in reduced toxicity and improved wound healing rates. Read More

    A Retrospective, Cost-minimization Analysis of Disposable and Traditional Negative Pressure Wound Therapy Medicare Paid Claims
    Ostomy Wound Manage 2018 01;64(1):26-33
    Wound Healing Center at Presence St. Francis Hospital, Evanston, IL.
    Traditional negative pressure wound therapy (NPWT) systems are considered durable. The pump is designed for use by numerous patients over a period of several years. Recently developed smaller, disposable devices are designed for single-patient use. Read More

    Recent Advances and Future Opportunities to Address Challenges in Offloading Diabetic Feet: A Mini-Review.
    Gerontology 2018 Jan 16. Epub 2018 Jan 16.
    Center for Lower Extremity Ambulatory Research (CLEAR), Dr. William M. Scholl College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.
    Diabetic foot ulcers (DFU) are a substantial dilemma for geriatric individuals with diabetes. The breakdown in tissue associated with DFU is typically a result of repetitive cycles of physical stress placed on the feet during weight-bearing activity. Accordingly, a key tenet in healing as well as preventing DFU is the use of offloading footwear to redistribute physical stress away from high stress locations such as bony prominences. Read More

    CODIFI (Concordance in Diabetic Foot Ulcer Infection): a cross-sectional study of wound swab versus tissue sampling in infected diabetic foot ulcers in England.
    BMJ Open 2018 01 31;8(1):e019437. Epub 2018 Jan 31.
    Clinical Trials Research Unit, University of Leeds, Leeds, UK.
    Objective: To determine the extent of agreement and patterns of disagreement between wound swab and tissue samples in patients with an infected diabetic foot ulcer (DFU).

    Design: Multicentre, prospective, cross-sectional study.

    Setting: Primary and secondary care foot ulcer/diabetic outpatient clinics and hospital wards across England. Read More

    Efficacy of Cellular Therapy for Diabetic Foot Ulcer: A Meta-Analysis of Randomized Controlled Clinical Trials.
    Cell Transplant 2017 Dec;26(12):1931-1939
    1 Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
    Diabetes mellitus is a widely spread chronic disease with growing incidence worldwide, and diabetic foot ulcer is one of the most serious complications of diabetes. Cellular therapy has shown promise in the management of diabetic foot ulcer in many preclinical experiments and clinical researches. Here, we performed a meta-analysis to evaluate the efficacy and safety of cellular therapy in the management of diabetic foot ulcer. Read More

    Three-week topical treatment with placenta-derived mesenchymal stem cells hydrogel in a patient with diabetic foot ulcer: A case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9212
    Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
    Rationale: Diabetic foot ulcer (DFU) is a chronic complication of diabetes characterized by continuity, repeatability, and nonhealing. In recent years, mesenchymal stem cells hydrogel complex has been a new emerging technique in the treatment of DFU. The placenta-derived mesenchymal stem cells (PDMSCs) hydrogel is multipotent, and can secrete growth factors, cytokines, and immunomodulatory substances which could accelerate wound healing. Read More

    Foot Kinetics and Kinematics Profile in Type 2 Diabetes Mellitus with Peripheral Neuropathy: A Hospital Based Study from South India.
    J Am Podiatr Med Assoc 2018 Feb 1. Epub 2018 Feb 1.
    § Manipal University Department of Medicine.
    Background: A kinetic change in thefoot like altered plantar pressure is the most common etiological risk factor for causing foot ulcers among people with diabetes mellitus. Kinematic alterations in joint angle and spatiotemporal parameters of the gait have also been frequently observed in participants with diabetes peripheral neuropathy. Diabetes peripheral neuropathy is the most common long-term standing complication of type 2 diabetes mellitus. Read More

    Silibinin protects human endothelial cells from high glucose-induced injury by enhancing autophagic response.
    J Cell Biochem 2018 Feb 1. Epub 2018 Feb 1.
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
    Silibin, a flavonoid from the seeds of Silybum marianum (L.) Gaertn. (Asteraceae) has been reported to produce curative properties in diabetes. Read More

    [The conspicuous leg].
    Internist (Berl) 2018 Jan 31. Epub 2018 Jan 31.
    Medizinische Klinik 2, Städtisches Klinikum Dresden, Friedrichstr. 41, 01067, Dresden, Deutschland.
    Symptoms of the leg or of both legs, may indicate a need for evaluation and/or treatment, which must be clarified urgently or even as an emergency situation. Among the diseases which must be considered from a vascular viewpoint are critical limb ischemia, suspicion of deep leg vein thrombosis and special forms of venous insufficiency. With respect to infections erysipelas and the syndrome of infected diabetic foot must be considered as well as peripheral and central leg paresis as orthopedic and neurological disorders, respectively. Read More

    Association between QTc interval prolongation and outcomes of diabetic foot ulcers: Data from a 4-year follow-up study in China.
    Diabetes Res Clin Pract 2018 Jan 31;138:26-34. Epub 2018 Jan 31.
    Shanghai Clinical Center for Endocrine and Metabolism Diseases, Yuanyang Subdivision for Diabetic Foot Disease, Shanghai Institute of Endocrine and Metabolism Disease, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China; Department of Internal Medicine, Shanghai Yuanyang Hospital, Shanghai 200031, China. Electronic address:
    Objectives: To examine whether QTc interval prolongation is an independent risk factor of outcomes in patients with diabetic foot ulcers (DFU).

    Research Design And Methods: 331 patients with type 2 diabetes and DFU hospitalized in a Chinese tertiary hospital were recruited. ECG was done at baseline and QTc interval was calculated through Bazett's formula. Read More

    Incidence of diabetic foot ulcer in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry.
    Diabetes Res Clin Pract 2018 Jan 30;137:183-189. Epub 2018 Jan 30.
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
    Aims: Although diabetic foot ulcer (DFU) is a serious diabetic complication, there have been no large-scale epidemiological studies of DFU in Japan. We prospectively investigated the incidences of DFU and limb amputation, the risk for developing DFU, and mortality in Japanese patients with type 2 diabetes.

    Methods: We followed 4870 participants (mean age, 65 years) with type 2 diabetes attending an outpatient diabetes clinic for a median of 5. Read More

    Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in Wound Healing Applications.
    Bioengineering (Basel) 2018 Jan 27;5(1). Epub 2018 Jan 27.
    Department of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, Tyler, TX 75799, USA.
    Wound healing is a complex tissue regeneration process that promotes the growth of new tissue to provide the body with the necessary barrier from the outside environment. In the class of non-healing wounds, diabetic wounds, and ulcers, dressing materials that are available clinically (e.g. Read More

    Chitosan treatment for skin ulcers associated with diabetes.
    Saudi J Biol Sci 2018 Jan 30;25(1):130-135. Epub 2017 Mar 30.
    Departamento de Ciencias de la Salud, Universidad de Sonora, Campus Cajeme, Ciudad Obregón, Sonora, Mexico.
    Infections, ulcerations, gangrene and, in severe cases, extremity amputation, are common complications among diabetic subjects. Various biomaterials have been utilized for the treatment of these lesions. Chitosan is an amino sugar with a low risk of toxicity and immune response. Read More

    Sheng-ji Hua-yu formula promotes diabetic wound healing of re-epithelization via Activin/Follistatin regulation.
    BMC Complement Altern Med 2018 Jan 29;18(1):32. Epub 2018 Jan 29.
    Department of Dermatology of Yueyang Hospital, Shanghai University of TCM, Shanghai, 200437, China.
    Background: Sheng-ji Hua-yu(SJHY) formula is one of the most useful Traditional Chinese medicine (TCM) in the treatment of the delayed diabetic wound. However, elucidating the related molecular biological mechanism of how the SJHY Formula affects excessive inflammation in the process of re-epithelialization of diabetic wound healing is a task urgently needed to be fulfilled. The objectives of this study is to evaluate the effect of antagonisic expression of pro-/anti-inflammatory factors on transforming growth factor-β(TGF-β) superfamily (activin and follistatin) in the process of re-epithelialization of diabetic wound healing in vivo, and to characterize the involvement of the activin/follistatin protein expression regulation, phospho-Smad (pSmad2), and Nuclear factor kappa B p50 (NF-kB) p50 in the diabetic wound healing effects of SJHY formula. Read More

    Predictors of Post-Thrombotic Ulcer after Acute DVT: The RIETE Registry.
    Thromb Haemost 2018 Feb 29;118(2):320-328. Epub 2018 Jan 29.
    Department of Internal Medicine, Hospital De Badalona Germans Trias I Pujol, Universidad Católica De Murcia, Spain.
    In patients with deep-vein thrombosis (DVT) in the lower limbs, venous ulcer is the most debilitating and end-stage clinical expression of the post-thrombotic syndrome (PTS). To date, risk factors for PTS-related ulcer in DVT patients have not been identified.We used the international observational RIETE registry to assess the evolution of PTS signs and symptoms during a 3-year follow-up period and to identify independent predictors of PTS ulcer at 1 year in patients with acute DVT. Read More

    Update on management of diabetic foot ulcers.
    Ann N Y Acad Sci 2018 Jan;1411(1):153-165
    Division of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Diabetic foot ulcers (DFUs) are a serious complication of diabetes that results in significant morbidity and mortality. Mortality rates associated with the development of a DFU are estimated to be 5% in the first 12 months, and 5-year morality rates have been estimated at 42%. The standard practices in DFU management include surgical debridement, dressings to facilitate a moist wound environment and exudate control, wound off-loading, vascular assessment, and infection and glycemic control. Read More

    Diabetic Foot Australia guideline on footwear for people with diabetes.
    J Foot Ankle Res 2018 15;11. Epub 2018 Jan 15.
    Diabetic Foot Australia, Brisbane, QLD Australia.
    Background: The aim of this paper was to create an updated Australian guideline on footwear for people with diabetes.

    Methods: We reviewed new footwear publications, (inter)national guidelines, and consensus expert opinion alongside the 2013 Australian footwear guideline to formulate updated recommendations.

    Result: We recommend health professionals managing people with diabetes should: (1) Advise people with diabetes to wear footwear that fits, protects and accommodates the shape of their feet. Read More

    Effect of low-level laser therapy on the healing process of donor site in patients with grade 3 burn ulcer after skin graft surgery (a randomized clinical trial).
    Lasers Med Sci 2018 Jan 24. Epub 2018 Jan 24.
    Al Nasr Sport Club Medical Section, Dubai, United Arab Emirates.
    Skin graft is a standard therapeutic technique in patients with deep ulcers, but managing donor site after grafting is very important. Although several modern dressings are available to enhance the comfort of donor site, using techniques that accelerate wound healing may enhance patient satisfaction. Low-level laser therapy (LLLT) has been used in several medical fields, including healing of diabetic, surgical, and pressure ulcers, but there is not any report of using this method for healing of donor site in burn patients. Read More

    Dysfunctional Wound Healing in Diabetic Foot Ulcers: New Crossroads.
    Curr Diab Rep 2018 Jan 23;18(1). Epub 2018 Jan 23.
    Department of Surgery, Section of Vascular Surgery, University of Michigan, 5364 Cardiovascular Center, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109-5867, USA.
    Purpose Of Review: Diabetic foot ulcerations (DFU) affect 25% of patients with diabetes mellitus during their lifetime and constitute a major health problem as they are often recalcitrant to healing due to a constellation of both intrinsic and extrinsic factors. The purpose of this review is to (1) detail the current mechanistic understanding of DFU formation and (2) highlight future therapeutic targets.

    Recent Findings: From a molecular perspective, DFUs exhibit a chronic inflammatory predisposition. Read More

    Emerging role of carbon monoxide in regulation of cellular pathways and in the maintenance of gastric mucosal integrity.
    Pharmacol Res 2018 Jan 29;129:56-64. Epub 2018 Jan 29.
    Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Cracow, Poland. Electronic address:
    Heme oxygenase (HO) catalyzes the degradation of toxic free heme to the equimolar amounts of biliverdin, Feand concurrently releases of carbon monoxide (CO). CO is nowadays increasingly recognized as an important signaling molecule throughout the body that is involved in many physiological processes and shows multidirectional biological activity. Recent evidence indicates that CO exhibits the anti-inflammatory, anti-proliferative, anti-apoptotic, anti-aggregatory and vasodilatory properties. Read More

    Emphysematous pancreatitis associated with penetrating duodenal ulcer.
    World J Gastroenterol 2017 Dec;23(48):8666-8670
    Unit of Internistic Ultrasound, Department of Medicine and Science of Aging, "G. D'Annunzio" University of Chieti, Chieti 66100, Italy.
    In the "proton pump inhibitors era", a penetrating peptic ulcer (PPU) represents an exceptional cause of abdominal pain, and was more frequently observed in the past where there was not an effective antacid treatment. Ulcer-induced pancreatitis is very rare, too, and manifests with persistent, intense pain radiating to the back. A mild to severe pancreatitis with peripancreatic fluid collection can be observed at imaging. Read More

    Biomechanical analysis of decellularized dermis and skin: Initial in vivo observations using optical cohesion tomography and vibrational analysis.
    J Biomed Mater Res A 2018 Jan 22. Epub 2018 Jan 22.
    Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, New Jersey, 08854.
    Measurement of the mechanical properties of skin in vivo has been complicated by the lack of methods that can accurately measure the viscoelastic properties without assuming values of Poisson's ratio and tissue density. In this paper, we present the results of preliminary studies comparing the mechanical properties of skin and scar tissue measured using a technique involving optical cohesion tomography (OCT) and vibrational analysis. This technique has been reported to give values of the modulus that correlate with those obtained from tensile measurements made on decellularized dermis (Shah et al. Read More

    Metataxonomic approach to decipher the polymicrobial burden in diabetic foot ulcer and its biofilm mode of infection.
    Int Wound J 2018 Jan 22. Epub 2018 Jan 22.
    Cholera and Biofilm Research Lab, Rajiv Gandhi Centre for Biotechnology, Trivandrum, Kerala, India.
    Chronic diabetic foot is a global burden affecting millions of people, and the chronicity of an ulcer is directly linked to the diverse bacterial burden and its biofilm mode of infection. The bacterial diversity of 100 chronic diabetic ulcer samples was profiled via traditional culturing method as well as metagenomic approach by sequencing the 16S rRNA V3 hyper-variable region on Illumina Miseq Platform (Illumina, Inc., San Diego, CA). Read More

    Metabolic response 4 years after gastric bypass in a complete cohort with type 2 diabetes mellitus.
    Diabetes Res Clin Pract 2018 Jan 31;137:224-230. Epub 2018 Jan 31.
    Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
    Aims: To evaluate the long-term remission rates of type 2 diabetes mellitus and associated comorbidities after gastric bypass surgery in a complete cohort, in a real-life clinic setting.

    Methods: A retrospective study of all consecutive patients with type 2 diabetes mellitus who underwent gastric bypass at a Veterans Affairs Medical Center from 2003 to 2010. The main outcome was remission of type 2 diabetes mellitus defined as HbA1c <6. Read More

    Efficiency of stem cell based therapy in the treatment of diabetic foot ulcer: a meta-analysis.
    Endocr J 2018 Jan 22. Epub 2018 Jan 22.
    Department of Burn and Plastic Surgery, 2nd Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.
    Diabetic foot ulcer is a chronic, refractory, frequent complication in diabetic patient. Its treatment often requires multidisciplinary joint efforts, diverse strategies have been adopted to address this annoying issue, including stem cell-based therapy/acellular dermal matrix/negative pressure wound therapy etc. However, consensus has not been reached. Read More

    Induction by innate defence regulator peptide 1018 of pro-angiogenic molecules and endothelial cell migration in a high glucose environment.
    Peptides 2018 Jan 17;101:135-144. Epub 2018 Jan 17.
    Medical Research Unit-Zacatecas, Mexican Institute for Social Security-IMSS, Zacatecas, Mexico. Electronic address:
    Synthetic innate defence regulator (IDR) peptides such as IDR-1018 modulate immunity to promote key protective functions including chemotaxis, wound healing, and anti-infective activity, while suppressing pro-inflammatory responses to non-pathological levels. Here we demonstrated that IDR-1018 induced, by up to 75-fold, pro-angiogenic VEGF-165 in keratinocytes but suppressed this isoform in endothelial cells. It also induced early angiogenin and prolonged anti-inflammatory TGFβ expression on endothelial cells, while suppressing early pro-inflammatory IL-1β expression levels. Read More

    Autolytic debridement and management of bacterial load with an occlusive hydroactive deressing impregnated with polyhexamethylene biguanide.
    Acta Biomed 2018 Jan 16;88(4):409-413. Epub 2018 Jan 16.
    University of Siena.
    Background: Debridement and control of bacterial load are key-points of wound care. The aim of this study is to evaluate the effectiveness of autolytic debridement and management of bacterial load (bioburden) of an occlusive hydro-active dressing impregnated with polyhexamethylene biguanide (PHMB).

    Methods: We used an occlusive dressing of hydro-active for leg ulcers' treatment (TenderWet-plus® - Hartmann). Read More

    Use of Oxidized Regenerated Cellulose/Collagen Matrix in Chronic Diabetic Foot Ulcers: A Systematic Review.
    Adv Skin Wound Care 2018 Feb;31(2):66-71
    At Guarulhos University in São Paulo, Brazil, Gisele Chicone, MS, RN, CWOCN, is a Master's Student, Nursing Postgraduate Program; Viviane Fernandes de Carvalho, PhD, RN, is Assistant Professor, Nursing Postgraduate Program; and André Oliveira Paggiaro, PhD, MD, is Assistant Professor, Nursing Postgraduate Program. The authors have disclosed no financial relationships related to this article. Submitted May 20, 2016; accepted in revised form September 7, 2016.
    Objective: Diabetic wounds that do not heal completely usually exhibit inflammatory markers, increased protease activity, and reduced levels of growth factors and cell count. A systematic review was performed to determine whether there is enough evidence to support the use of an oxidized regenerated cellulose/collagen matrix (ORC+C) to treat diabetic foot ulcers (DFUs).

    Methods: Study authors analyzed randomized controlled trials (RCTs) on ORC+C dressings for the treatment of DFUs. Read More

    1 OF 141