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    24941 results match your criteria Diabetic Neuropathy

    1 OF 499

    The effect of peripheral neuropathy on lower limb muscle strength in diabetic individuals.
    Clin Biomech (Bristol, Avon) 2017 Feb 9;43:67-73. Epub 2017 Feb 9.
    Laboratory of Skeletal Muscle Plasticity, Department of Physical Therapy, Federal University of São Carlos, SP, Brazil. Electronic address:
    Background: Skeletal muscle strength is poorly described and understood in diabetic participants with diabetic peripheral neuropathy. This study aimed to investigate the extensor and flexor torque of the knee and ankle during concentric, eccentric, and isometric contractions in men with diabetes mellitus type 2 with and without diabetic peripheral neuropathy.

    Methods: Three groups of adult men (n=92), similar in age, body mass index, and testosterone levels, were analyzed: 33 non-diabetic controls, 31 with type 2 diabetes mellitus, and 28 with diabetic peripheral neuropathy. Read More

    Effects of Dimethyloxalylglycine-Embedded Poly(ε-caprolactone) Fiber Meshes on Wound Healing in Diabetic Rats.
    ACS Appl Mater Interfaces 2017 Feb 17. Epub 2017 Feb 17.
    Impaired wound healing in diabetic patients is associated with altered inflammatory responses, poor angiogenesis, deficient extracellular matrix (ECM) component, and peripheral neuropathy. To develop a wound dressing that is capable of the controlled delivery of bioactive small molecules that can improve diabetic wound healing, dimethyloxalylglycine (DMOG)-embedded poly(ε-caprolactone) (PCL) fiber (PCLF/DMOG) meshes are fabricated by electrospinning, and the effects of the PCLF/DMOG meshes on wound healing in diabetic rats are evaluated. Electrospun PCLF/DMOG meshes increase not only the wound closure, re-epithelialization ratio, epithelial maturation (K-10-positive epidermis), and collagen-positive area but also the numbers of angiogenic marker (CD-31)-positive and neuronal marker (neurofilament)-positive cells compared to PCLF (p<0. Read More

    Transplantation of lineage-negative stem cells in pterygopalatine artery ligation induced retinal ischemia-reperfusion injury in mice.
    Mol Cell Biochem 2017 Feb 16. Epub 2017 Feb 16.
    Neuroscience Research Lab, Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Retinal ischemia is a condition associated with retinal degenerative diseases such as glaucoma, diabetic retinopathy, and other optic neuropathies, leading to visual impairment and blindness worldwide. Currently, there is no therapy available for ischemic retinopathies. Therefore, the aim of this study was to test a murine model of pterygopalatine artery ligation-induced retinal injury for transplantation of mouse bone marrow-derived lineage-negative (lin-ve) stem cells. Read More

    Valproate Attenuates Endoplasmic Reticulum Stress-Induced Apoptosis in SH-SY5Y Cells via the AKT/GSK3β Signaling Pathway.
    Int J Mol Sci 2017 Feb 8;18(2). Epub 2017 Feb 8.
    Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.
    Endoplasmic reticulum (ER) stress-induced apoptosis plays an important role in a range of neurological disorders, such as neurodegenerative diseases, spinal cord injury, and diabetic neuropathy. Valproate (VPA), a typical antiepileptic drug, is commonly used in the treatment of bipolar disorder and epilepsy. Recently, VPA has been reported to exert neurotrophic effects and promote neurite outgrowth, but its molecular mechanism is still unclear. Read More

    Impaired Axonal Regeneration in Diabetes. Perspective on the Underlying Mechanism from In Vivo and In Vitro Experimental Studies.
    Front Endocrinol (Lausanne) 2017 1;8:12. Epub 2017 Feb 1.
    Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine , Hirosaki , Japan.
    Axonal regeneration after peripheral nerve injury is impaired in diabetes, but its precise mechanisms have not been elucidated. In this paper, we summarize the progress of research on altered axonal regeneration in animal models of diabetes and cultured nerve tissues exposed to hyperglycemia. Impaired nerve regeneration in animal diabetes can be attributed to dysfunction of neurons and Schwann cells, unfavorable stromal environment supportive of regenerating axons, and alterations of target tissues receptive to reinnervation. Read More

    Spinal Disinhibition in Experimental and Clinical Painful Diabetic Neuropathy.
    Diabetes 2017 Feb 15. Epub 2017 Feb 15.
    Institute of Human Development, Centre for Endocrinology & Diabetes, Faculty of Medical and Human Sciences, University of Manchester and NIHR/Wellcome Trust Clinical Research Facility, Manchester, M13 9NT, UK
    Impaired rate dependent depression (RDD) of the Hoffman-reflex is associated with reduced dorsal spinal cord potassium chloride co-transporter expression and impaired spinal GABAA receptor function, indicative of spinal inhibitory dysfunction. We have investigated the pathogenesis of impaired RDD in diabetic rodents exhibiting features of painful neuropathy and the translational potential of this marker of spinal inhibitory dysfunction in human painful diabetic neuropathy. Impaired RDD and allodynia were present in type 1 and type 2 diabetic rats but not in rats with type 1 diabetes receiving insulin supplementation that did not restore normoglycemia. Read More

    Association between metformin use and below-the-knee arterial calcification score in type 2 diabetic patients.
    Cardiovasc Diabetol 2017 Feb 15;16(1):24. Epub 2017 Feb 15.
    INSERM U-1088, Pathophysiological Mechanisms and Consequences of Cardiovascular Calcifications, 80025, Amiens, France.
    Background: Vascular calcification (VC) is common in type 2 diabetes, and is associated with cardiovascular complications. Recent preclinical data suggest that metformin inhibits VC both in vitro and in animal models. However, metformin's effects in patients with diabetic VC have not previously been characterized. Read More

    Lipids: A Suitable Therapeutic Target in Diabetic Neuropathy?
    J Diabetes Res 2017 16;2017:6943851. Epub 2017 Jan 16.
    School of Medicine, Universidad de Los Andes, Bogotá, Colombia; Fundación Santa Fe de Bogotá, Department of Internal Medicine, Section of Endocrinology, Bogotá, Colombia.
    Diabetic polyneuropathy (DPN) encompasses multiple syndromes with a common pathogenesis. Glycemic control shows a limited correlation with DPN, arguing in favor of major involvement of other factors, one of which is alterations of lipid and lipoprotein metabolism. Consistent associations have been found between plasma triglycerides/remnant lipoproteins and the risk of DPN. Read More

    Evaluating the Measurement Properties of the Self-Assessment of Treatment Version II, Follow-Up Version, in Patients with Painful Diabetic Peripheral Neuropathy.
    Pain Res Treat 2017 16;2017:6080648. Epub 2017 Jan 16.
    Evidera, Bethesda, MD, USA.
    Background. The Self-Assessment of Treatment version II (SAT II) measures treatment-related improvements in pain and impacts and impressions of treatment in neuropathic pain patients. The measure has baseline and follow-up versions. Read More

    PI3K/Akt pathway: a potential therapeutic target for chronic pain.
    Curr Pharm Des 2017 Feb 10. Epub 2017 Feb 10.
    Cancer Center, Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan, China.
    Chronic pain is among the most disabling and costly disorders, with prevalence ranging from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory due to our poor understanding of its mechanisms. Thus, novel therapeutic targets need to be found in order to improve these patients' quality of life. Read More

    Does Endurance Training Compensate for Neurotrophin Deficiency Following Diabetic Neuropathy?
    Iran Red Crescent Med J 2016 Oct 6;18(10):e37757. Epub 2016 Aug 6.
    Department of Statistics, Faculty of Mathematics and Computer, Shahid Bahonar University of Kerman, Kerman, IR Iran.
    Background: A lack of neurotrophic support is believed to contribute to the development of diabetic neuropathy. On the other hand, neurotrophins have consistently been shown to increase in the central and peripheral nervous system following exercise, but the effects of exercise intervention on brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in diabetic neuropathy are not understood.

    Objectives: This experimental study was designed and carried out at the Tarbiat Modares university (TMU) in Tehran, Iran, to investigate the hypothesis that increased activity as endurance training can help to increase the endogenous expression of neurotrophins in diabetic rats. Read More

    Uncovering sensory axonal dysfunction in asymptomatic type 2 diabetic neuropathy.
    PLoS One 2017 9;12(2):e0171223. Epub 2017 Feb 9.
    Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes.
    This study investigated sensory and motor nerve excitability properties to elucidate the development of diabetic neuropathy. A total of 109 type 2 diabetes patients were recruited, and 106 were analyzed. According to neuropathy severity, patients were categorized into G0, G1, and G2+3 groups using the total neuropathy score-reduced (TNSr). Read More

    Puerarin may protect against Schwann cell damage induced by glucose fluctuation.
    J Nat Med 2017 Feb 8. Epub 2017 Feb 8.
    Department of Traditional Chinese Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yantaxi Rd, Xi'an, 710061, Shanxi, China.
    Puerarin is one of the major active ingredients in Gegen, a traditional Chinese herb that has been reported to have a wide variety of beneficial pharmacology functions. Previous studies have implicated that the damaging effects of hyperglycemia resulting from oxidative stress and glucose fluctuation may be more dangerous than constant high glucose in the development of diabetes-related complications. The present study focuses on the effects of puerarin on glucose fluctuation-induced oxidative stress-induced Schwann cell (SC) apoptosis in vitro. Read More

    Advanced glycation end products induce brain-derived neurotrophic factor release from human platelets through the Src-family kinase activation.
    Cardiovasc Diabetol 2017 Feb 8;16(1):20. Epub 2017 Feb 8.
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Asahimachi, Niigata, 951-8585, Japan.
    Background: Brain-derived neurotrophic factor (BDNF) exerts beneficial effects not only on diabetic neuropathies but also on cardiovascular injury. There is argument regarding the levels of serum BDNF in patients with diabetes mellitus (DM). Because BDNF in peripheral blood is rich in platelets, this may represent dysregulation of BDNF release from platelets. Read More

    An integrated perspective on diabetic, alcoholic, and drug-induced neuropathy, etiology, and treatment in the US.
    J Pain Res 2017 20;10:219-228. Epub 2017 Jan 20.
    Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
    Neuropathic pain (NeuP) is a syndrome that results from damaged nerves and/or aberrant regeneration. Common etiologies of neuropathy include chronic illnesses and medication use. Chronic disorders, such as diabetes and alcoholism, can cause neuronal injury and consequently NeuP. Read More

    Proinflammatory Cytokines Predict the Incidence and Progression of Distal Sensorimotor Polyneuropathy: KORA F4/FF4 Study.
    Diabetes Care 2017 Feb 7. Epub 2017 Feb 7.
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
    Objective: Experimental and epidemiological studies have implicated inflammatory processes in the pathogenesis of distal sensorimotor polyneuropathy (DSPN), but prospective studies are lacking. We hypothesized that biomarkers of inflammation predict the development and progression of DSPN in a population-based cohort.

    Research Design And Methods: This study was based on participants aged 62-81 years from the Cooperative Health Research in the Region of Augsburg (KORA) F4/FF4 cohort, with a mean follow-up of 6. Read More

    Association between ankle equinus and plantar pressures in people with diabetes. A systematic review and meta-analysis.
    Clin Biomech (Bristol, Avon) 2017 Jan 31;43:8-14. Epub 2017 Jan 31.
    School of Health Sciences, Faculty of Health, University of Newcastle, Australia.
    Background: Diabetes is one of the most common chronic diseases in the world and is associated with a life-time risk of foot ulcer of 12-25%. Diabetes related restriction in ankle joint range of dorsiflexion is proposed to contribute to elevated plantar pressures implicated in the development of foot ulcers.

    Methods: A systematic search of EBSCO Megafile Premier (containing MEDLINE, CINAHL, SPORTSdiscus and Academic Search Complete) and The Cochrane Library was conducted to 23rd November 2016. Read More

    [Ischemic origin of diabetic foot disease. Epidemiology, difficulties of diagnosis, options for prevention and revascularization].
    Orv Hetil 2017 Feb;158(6):203-211
    Angiológia, Szent Imre Egyetemi Oktatókórház Budapest, Tétényi út 12-16., 1115.
    "Diabetic foot" as definition covers a multifactorial clinical condition. According to the recent epidemiological data, the role of lower limb ischemia is getting more influential over other pathological causes, like neuropathy, infections and bone or soft tissue deformity. In diabetes, vascular disease leads to increased risk for leg ulcers and minor or major amputations. Read More

    Prevalence of Sensory Neuropathy in Type 2 Diabetes Mellitus and Its Correlation with Duration of Disease.
    Kathmandu Univ Med J (KUMJ) 2016 Apr-Jun;14(54):120-124
    Department of Cardiology, Kathmandu Medical College Teaching Hospital, Kathmandu, Nepal.
    Background Peripheral neuropathy is one of the most common and distressing late complication of diabetes mellitus. Ignorance of the complications may develop foot ulcers and gangrene requiring amputation. Objective The main objective of this study is to find out the prevalence of sensory neuropathy in type 2 diabetes mellitus and to compare it with the duration of disease. Read More

    Awareness of diabetic foot disease amongst patients with type 2 diabetes mellitus attending the chronic outpatients department at a regional hospital in Durban, South Africa.
    Afr J Prim Health Care Fam Med 2016 Nov 17;8(1):e1-e8. Epub 2016 Nov 17.
    Discipline of Family Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban.
    Background: Diabetic foot disease (DFD) is a major challenge for the healthcare system, with enormous economic consequences for people living with diabetes, their families, and society, affecting both quality of life and quality of care. The study aim was to assess the level of awareness of DFD amongst patients with type 2 diabetes mellitus (T2DM).

    Methods: An observational descriptive cross-sectional study was conducted at the chronic outpatients department of a regional hospital in Durban, South Africa. Read More

    Antinociceptive interaction of gabapentin with minocycline in murine diabetic neuropathy.
    Inflammopharmacology 2017 Feb 28;25(1):91-97. Epub 2017 Feb 28.
    Faculty of Medicine, School of Pharmacy, Andres Bello University, República 590, Santiago, Chile.
    Objective: Diabetic neuropathy (DN) is the most common complication of diabetes and pain is one of the main symptoms of diabetic neuropathy, however, currently available drugs are often ineffective and complicated by adverse events. The purpose of this research was to evaluate the antinociceptive interaction between gabapentin and minocycline in a mice experimental model of DN by streptozocin (STZ).

    Methods: The interaction of gabapentin with minocycline was evaluated by the writhing and hot plate tests at 3 and 7 days after STZ injection or vehicle in male CF1 mice. Read More

    A model to estimate cost-savings in diabetic foot ulcer prevention efforts.
    J Diabetes Complications 2017 Jan 21. Epub 2017 Jan 21.
    Southern Arizona Limb Salvage Alliance (SALSA), University of Arizona College of Medicine, Tucson, AZ.
    Background: Sustained efforts at preventing diabetic foot ulcers (DFUs) and subsequent leg amputations are sporadic in most health care systems despite the high costs associated with such complications. We sought to estimate effectiveness targets at which cost-savings (i.e. Read More

    The Effect of Aerobic Exercise Training on Plasma Apelin Levels and Pain Threshold in T1DM Rats.
    Iran Red Crescent Med J 2016 Sep 11;18(9):e31737. Epub 2016 May 11.
    Exercise Physiology Department, Faculty of Physical Education and Sport Sciences, Bu-Ali Sina University, Hamadan, IR Iran.
    Background: Diabetes mellitus (types 1 and 2) leads to secondary complications such as neuropathy, which reduce a patient's quality of life. Apelin and its receptor, APJ, have been shown to have antinociceptive effects and to decrease blood glucose levels.

    Objectives: The present experimental study was conducted in Iran and investigated the role of apelin, which is used to manage type 1 diabetes mellitus, during exercise training. Read More

    Photobiostimulation reverses allodynia and peripheral nerve damage in streptozotocin-induced type 1 diabetes.
    Lasers Med Sci 2017 Jan 30. Epub 2017 Jan 30.
    Department of Anatomy, Biomedical Sciences Institute, University of São Paulo, Av. Prof. Lineu Prestes, 2415, 05508-900, São Paulo, Brazil.
    For better evaluation of the efficacy of low-level laser therapy in treating painful diabetic neuropathy and in protecting nerve fiber damage, we conducted a study with type 1 diabetic rats induced by streptozotocin. It is well known that diabetic peripheral neuropathy is the leading cause of pain in those individuals who suffer from diabetes. Despite the efficacy of insulin in controlling glucose level in blood, there is no effective treatment to prevent or reverse neuropathic damage for total pain relief. Read More

    Effect of bilirubin concentration on the risk of diabetic complications: A meta-analysis of epidemiologic studies.
    Sci Rep 2017 Jan 30;7:41681. Epub 2017 Jan 30.
    Department of mathematics, School of Fundamental Sciences, China Medical University, Shenyang, People's Republic of China.
    Diabetes can affect many parts of the body and is associated with serious complications. Oxidative stress is a major contributor in the pathogenesis of diabetic complications and bilirubin has been shown to have antioxidant effects. The number of studies on the effect of bilirubin on the risk of diabetic complications has increased, but the results are inconsistent. Read More

    Schwann cell interactions with axons and microvessels in diabetic neuropathy.
    Nat Rev Neurol 2017 Jan 30. Epub 2017 Jan 30.
    Department of Neurology, Danish Pain Research Center and IDNC, Aarhus University Hospital, Nørrebrogade, 8000 Aarhus C, Denmark.
    The prevalence of diabetes worldwide is at pandemic levels, with the number of patients increasing by 5% annually. The most common complication of diabetes is peripheral neuropathy, which has a prevalence as high as 50% and is characterized by damage to neurons, Schwann cells and blood vessels within the nerve. The pathogenic mechanisms of diabetic neuropathy remain poorly understood, impeding the development of targeted therapies to treat nerve degeneration and its most disruptive consequences of sensory loss and neuropathic pain. Read More

    Tang-Luo-Ning Improves Mitochondrial Antioxidase Activity in Dorsal Root Ganglia of Diabetic Rats: A Proteomics Study.
    Biomed Res Int 2017 4;2017:8176089. Epub 2017 Jan 4.
    Department of Endocrinology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
    Tang-luo-ning (TLN) is a traditional Chinese herbal recipe for treating diabetic peripheral neuropathy (DPN). In this study, we investigated mitochondrial protein profiles in a diabetic rat model and explored the potential protective effect of TLN. Diabetic rats were established by injection of streptozocin (STZ) and divided into model, alpha lipoic acid (ALA), and TLN groups. Read More

    Sensory and autonomic function and structure in footpads of a diabetic mouse model.
    Sci Rep 2017 Jan 27;7:41401. Epub 2017 Jan 27.
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Sensory and autonomic neuropathy affects the majority of type II diabetic patients. Clinically, autonomic evaluation often focuses on sudomotor function yet this is rarely assessed in animal models. We undertook morphological and functional studies to assess large myelinated and small unmyelinated axons in the db/db type II diabetes mouse model. Read More

    Social Media as a Platform for Information About Diabetes Foot Care: A Study of Facebook Groups.
    Can J Diabetes 2017 Feb;41(1):97-101
    Department of Family Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:
    Background: Diabetes is one of the most challenging chronic health conditions in the current era. Diabetes-related foot problems need proper patient education, and social media could a play role to disseminate proper information.

    Method: A systematic search was performed on Facebook groups using the key words "diabetes foot care", "diabetes foot", "diabetes foot management" and "podiatric care". Read More

    HLA class II alleles and risk for peripheral neuropathy in type 2 diabetes patients.
    Neural Regen Res 2016 Nov;11(11):1839-1844
    Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Psoriasis Research Center, Department of Dermatology, Farshchian Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
    The potential impact of human leukocyte antigen (HLA) genotype variations on development of diabetic peripheral neuropathy (DPN) is not well determined. This study aimed to identify the association of HLA class II alleles with DPN in type 2 diabetes (T2D) patients. Totally 106 T2D patients, 49 with DPN and 57 without DPN, and 100 ethnic-matched healthy controls were analyzed. Read More

    Endomorphin-2 Inhibition of Substance P Signaling within Lamina I of the Spinal Cord Is Impaired in Diabetic Neuropathic Pain Rats.
    Front Mol Neurosci 2016 10;9:167. Epub 2017 Jan 10.
    Department of Anatomy and Histology and Embryology, K.K. Leung Brain Research Centre, The Fourth Military Medical UniversityXi'an, China; Collaborative Innovation Center for Brain Science, Fudan UniversityShanghai, China.
    Opiate analgesia in the spinal cord is impaired in diabetic neuropathic pain (DNP), but until now the reason is unknown. We hypothesized that it resulted from a decreased inhibition of substance P (SP) signaling within the dorsal horn of the spinal cord. To investigate this possibility, we evaluated the effects of endomorphin-2 (EM2), an endogenous ligand of the μ-opioid receptor (MOR), on SP release within lamina I of the spinal dorsal horn (SDH) in rats with DNP. Read More

    O-GlcNAc Transferase is Essential for Sensory Neuron Survival and Maintenance.
    J Neurosci 2017 Jan 23. Epub 2017 Jan 23.
    The F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston MA 02115, USA
    O-GlcNAc transferase (OGT) regulates a wide range of cellular processes through the addition of the O-GlcNAc sugar moiety to thousands of protein substrates. Its activity is affected by nutrient availability, and therefore its role has been broadly studied in metabolic tissues. OGT is enriched in the nervous system, but little is known about its importance in basic neuronal processes in vivo Here, we show that OGT is essential for sensory neuron survival and maintenance in mice. Read More

    Metabolic Syndrome, Neurotoxic 1-Deoxysphingolipids and Nervous Tissue Inflammation in Chronic Idiopathic Axonal Polyneuropathy (CIAP).
    PLoS One 2017 23;12(1):e0170583. Epub 2017 Jan 23.
    Department of Neurology, RWTH Aachen University, Aachen, Germany.
    Aim: Chronic idiopathic axonal polyneuropathy (CIAP) is a slowly progressive, predominantly sensory, axonal polyneuropathy, with no aetiology being identified despite extensive investigations. We studied the potential role of the metabolic syndrome, neurotoxic 1-deoxysphingolipids (1-deoxySLs), microangiopathy and inflammation in sural nerve biopsies.

    Methods: We included 30 CIAP-patients, 28 with diabetic distal symmetrical polyneuropathy (DSPN) and 31 healthy controls. Read More

    Acupuncture for the Treatment of Peripheral Neuropathy: A Systematic Review and Meta-Analysis.
    J Altern Complement Med 2017 Jan 23. Epub 2017 Jan 23.
    Department of Neurology, Oregon Health and Science University , Portland, OR.
    Objectives: Neuropathy and its associated pain pose great therapeutic challenges. While there has been a recent surge in acupuncture use and research, little remains known about its effects on nerve function. This review aims to assess the efficacy of acupuncture in the treatment of neuropathy of various etiologies. Read More

    Retinal sensitivity changes associated with diabetic neuropathy in the absence of diabetic retinopathy.
    Br J Ophthalmol 2017 Jan 20. Epub 2017 Jan 20.
    Vision and Eye Research Unit, Anglia Ruskin University, Cambridge, UK.
    Purpose: To explore any relationship between the markers of early retinal neuronal damage and peripheral diabetic neuropathy in subjects with no diabetic retinopathy (DR).

    Methods: A cross-sectional study in which type 2 diabetic subjects (n=743) without DR were studied. Visual functions including visual acuity, contrast sensitivity, colour vision, retinal sensitivity using microperimeter and retinal thicknesses by spectral domain optical coherence tomography were measured. Read More

    Association of Diabetes Related Complications with Heart Rate Variability among a Diabetic Population in the UAE.
    PLoS One 2017 20;12(1):e0168584. Epub 2017 Jan 20.
    School of Community Health, Charles Sturt University, Albury, New South Wales, Australia.
    Microvascular, macrovascular and neurological complications are the key causes of morbidity and mortality among type II diabetes mellitus (T2DM) patients. The aim of this study was to investigate the alterations of cardiac autonomic function of diabetic patients in relation to three types of diabetes-related complications. ECG recordings were collected and analyzed from 169 T2DM patients in supine position who were diagnosed with nephropathy (n = 55), peripheral neuropathy (n = 64) and retinopathy (n = 106) at two hospitals in the UAE. Read More

    Treatment of Diabetic Autonomic Neuropathy in Older Adults with Diabetes Mellitus.
    Consult Pharm 2016 Nov;31(11):633-645
    Objective: To review the epidemiology, pathophysiology, screening and diagnosis, and optimal treatment of diabetic autonomic neuropathy (DAN) and its implications in older adults.

    Data Sources, Study Selection, Data Extraction, Data Synthesis: A search of PubMed using the Mesh terms "diabetes," "type 1," "insulin-dependent," "T1DM," and "diabetic autonomic neuropathy" was performed to find relevant primary literature. Additional search terms "epidemiology," "geriatric," and "risk" were employed. Read More

    Type 1 diabetic patients with peripheral neuropathy have pan-enteric prolongation of gastrointestinal transit times and an altered caecal pH profile.
    Diabetologia 2017 Jan 20. Epub 2017 Jan 20.
    Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Mølleparkvej 4, DK-9000, Aalborg, Denmark.
    Aims/hypothesis: We hypothesised that type 1 diabetic patients with established diabetic sensorimotor polyneuropathy (DSPN) would have segmental and/or pan-enteric dysmotility in comparison to healthy age-matched controls. We aimed to investigate the co-relationships between gastrointestinal function, degree of DSPN and clinical symptoms.

    Methods: An observational comparison was made between 48 patients with DSPN (39 men, mean age 50 years, range 29-71 years), representing the baseline data of an ongoing clinical trial (representing a secondary analysis of baseline data collected from an ongoing double-blind randomised controlled trial investigating the neuroprotective effects of liraglutide) and 41 healthy participants (16 men, mean age 49 years, range 30-78) who underwent a standardised wireless motility capsule test to assess gastrointestinal transit. Read More

    Interaction of capsaicin with calf thymus DNA: A multi-spectroscopic and molecular modelling study.
    Int J Biol Macromol 2017 Apr 16;97:392-402. Epub 2017 Jan 16.
    Department of Agricultural Microbiology, Aligarh Muslim University, Aligarh, 202002, India. Electronic address:
    Studying the mode of interaction between small molecules and DNA has received much attention in recent years, as many drugs have been reported to directly interact with DNA thereby regulating the expression of many genes. Capsaicin is a capsaiciniods family phytocompound having many therapeutic applications including diabetic neuropathy, rheumatoid arthritis, prevention of DNA strand breaks and chromosomal aberrations. In this study, we have investigated the interaction of capsaicin with calf thymus DNA using a number of biophysical techniques to get an insight and better understanding of the interaction mechanism. Read More

    Impaired olfactory function is related to the presence of neuropathy in adults with type 1 diabetes.
    Diab Vasc Dis Res 2017 Mar 20;14(2):139-143. Epub 2017 Jan 20.
    1 Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznań, Poland.
    Introduction: Olfactory dysfunction is suggested to be a clinical manifestation of central diabetic neuropathy. The aim of the study was to assess olfactory function in adult patients with type 1 diabetes.

    Materials And Methods: A total of 106 patients with type 1 diabetes and 30 healthy subjects were included in the study. Read More

    Expression of CD4(+) CD28(null) T lymphocytes in children and adolescents with type 1 diabetes mellitus: Relation to microvascular complications, aortic elastic properties, and carotid intima media thickness.
    Pediatr Diabetes 2017 Jan 19. Epub 2017 Jan 19.
    Pediatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
    Background: Cardiovascular risk in type 1 diabetes mellitus (T1DM) is associated with endothelial dysfunction, inflammation, and altered immunity. CD4(+) CD28(null) T-cells are a subset of long-lived cytotoxic CD4(+) T-lymphocytes with proatherogenic and plaque-destabilizing properties. We hypothesized that the frequency of CD4(+) CD28(null) T-cells may be altered in T1DM and related to vascular complications. Read More

    Mediators of diabetic neuropathy: is hyperglycemia the only culprit?
    Curr Opin Endocrinol Diabetes Obes 2017 Jan 16. Epub 2017 Jan 16.
    aDepartment of Neurology, Medical University of Vienna, Vienna, Austria bDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
    Purpose Of Review: Diabetic peripheral neuropathy (DPN) is a disabling, highly prevalent complication of both type 1 and type 2 diabetes mellitus (T1DM and T2DM). Large clinical studies support the concept that, in addition to hyperglycemia, components of the metabolic syndrome (MetS) may underlie the pathogenesis of DPN, especially in T2DM. This review will present the evidence supporting the MetS and its individual components as potential causal factors for the development of neuropathy. Read More

    Renal Function in Type 2 Diabetes Following Gastric Bypass.
    Dtsch Arztebl Int 2016 Dec;113(49):827-833
    Department of General, Visceral and Transplantation Surgery at Heidelberg University Hospital; Department of Endocrinology, Metabolism and Clinical Chemistry at Heidelberg University Hospital, Heidelberg.
    Background: Metabolic surgery for obese patients with type 2 diabetes (T2D) yields short- and long-term remission rates of 60-90%. Its effects on diabetesassociated complications such as neuropathy and nephropathy have not been well studied to date. Hardly any data are available on this subject with respect to moderately obese patients (body mass index [BMI] 25-35 kg/m2) with insulin-dependent T2D. Read More

    How to prevent the microvascular complications of type 2 diabetes beyond glucose control.
    BMJ 2017 Jan 17;356:i6505. Epub 2017 Jan 17.
    Geriatric Research, Education and Clinical Center (GRECC), Miami VA Healthcare System, Miami, FL, USA.
    Microvascular complications (retinopathy, nephropathy, and neuropathy) affect hundreds of millions of patients with type 2 diabetes. They usually affect people with longstanding or uncontrolled disease, but they can also be present at diagnosis or in those yet to have a diagnosis made. The presentation and progression of these complications can lead to loss of visual, renal, and neurologic functions, impaired mobility and cognition, poor quality of life, limitations for employment and productivity, and increased costs for the patient and society. Read More

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