29,451 results match your criteria Diabetic Neuropathy


Metformin protects from oxaliplatin induced peripheral neuropathy in rats.

Neurobiol Pain 2020 Aug-Dec;8:100048. Epub 2020 May 22.

Center for Integrative Biology, Faculty of Sciences, Universidad Mayor de Chile, Santiago 8580745, Chile.

Oxaliplatin is a commonly used drug to treat cancer, extending the rate of disease-free survival by 20% in colorectal cancer. However, oxaliplatin induces a disabling form of neuropathy resulting in more than 60% of patients having to reduce or discontinue oxaliplatin, negatively impacting their chance of survival. Oxaliplatin-induced neuropathies are accompanied by degeneration of sensory fibers in the epidermis and hyperexcitability of sensory neurons. Read More

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http://dx.doi.org/10.1016/j.ynpai.2020.100048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260677PMC

Prevalence and Correlates of Cardiovascular Autonomic Neuropathy Among Patients with Diabetes in Uganda: A Hospital-Based Cross-sectional Study.

Glob Heart 2020 Mar 2;15(1):21. Epub 2020 Mar 2.

Department of Internal Medicine, Mbarara University of Science and Technology, Mbarara, UG.

Background: Cardiovascular autonomic neuropathy (CAN) is a common complication in individuals with diabetes mellitus (DM) but often overlooked in clinical practice. The burden and correlates of CAN have not been extensively studied in low-income countries, particularly in sub-Saharan Africa.

Objectives: To determine the prevalence and correlates of CAN among adults in ambulatory diabetes care in southwestern Uganda. Read More

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http://dx.doi.org/10.5334/gh.765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218768PMC

Clinical Data for the Use of Cannabis-Based Treatments: A Comprehensive Review of the Literature.

Ann Pharmacother 2020 Jun 2:1060028020930189. Epub 2020 Jun 2.

Intermountain Healthcare, Taylorsville, UT, USA.

To compile and synthesize the available literature describing medical cannabis use across various disease states. PubMed, EBSCO, and Google Scholar searches were conducted using MeSH and/or keywords. Studies were included if they described the use of cannabis-based products and medications in the treatment of a predefined list of disease states in humans and were published in English. Read More

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http://dx.doi.org/10.1177/1060028020930189DOI Listing

Danggui Sini decoction for treating diabetic peripheral neuropathy: A protocol of systematic review and meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2020 May;99(21):e20482

Hospital of Chengdu University of Traditional Chinese Medicine.

Background: Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetic patients, which seriously affects the quality of life of patients. At present, mainstream drugs have problems such as poor efficacy and side effects. Traditional Chinese medicine (TCM) has extensive clinical experience in the prevention and treatment of diabetes and chronic complications, and it also shows clear advantages in the treatment of DPN. Read More

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http://dx.doi.org/10.1097/MD.0000000000020482DOI Listing

Therapies for diabetic gastroparesis: A protocol for a systematic review and network meta-analysis.

Medicine (Baltimore) 2020 May;99(21):e20461

Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine.

Background: Diabetic gastroparesis (DG) is a common autonomic neuropathy which impacts on nutritional state and quality of life in diabetic patients, and it also adversely affects glycemic control in diabetes. The prevalence of DG is growing with the number of patients with diabetes continues to increase. However, there is no definitive answer as to which of the current therapies is the best for the clinical treatment of the different manifestations of DG. Read More

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http://dx.doi.org/10.1097/MD.0000000000020461DOI Listing

Sensorimotor and gait training improves proprioception, nerve function, and muscular activation in patients with diabetic peripheral neuropathy: a randomized control trial.

J Musculoskelet Neuronal Interact 2020 Jun;20(2):234-248

Diabetes Research Group, Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia (A Central University), New Delhi, India.

Objectives: To examine the effect of sensorimotor and gait training on proprioception, nerve function, and muscle activation in diabetic peripheral neuropathy (DPN) patients.

Methods: Thirty-eight (25 male and 13 female) participants with DPN were selected and randomly allocated to intervention and control group. Participants in the intervention group were provided sensorimotor and gait training for eight weeks (3 days/week) along with diabetes and foot care education; participants in the control group received diabetes and foot care education only. Read More

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Changes of circulating neuregulin 4 and its relationship with 25-hydroxy vitamin D and other diabetic vascular complications in patients with diabetic peripheral neuropathy.

Diabetol Metab Syndr 2020 19;12:42. Epub 2020 May 19.

1Department of Endocrinology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000 China.

Background: Neuregulin 4 (Nrg4) is a novel neurotrophic adipokine associated with the development of diabetic peripheral neuropathy (DPN), however, the pathological mechanism remains poorly understood. The purpose of our study was to investigate the association of circulating Nrg4 with DPN and 25-hydroxy vitamin D [25(OH)D], a multifunctional secosteroid hormone that regulates other neurotrophic factors and adipokines gene expression, and other diabetic vascular complications.

Methods: Circulating Nrg4 levels were measured with an ELISA kit in 164 newly diagnosed type 2 diabetes mellitus (nT2DM) patients. Read More

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http://dx.doi.org/10.1186/s13098-020-00550-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236347PMC

Cohort profile: the Singapore diabetic cohort study.

BMJ Open 2020 May 30;10(5):e036443. Epub 2020 May 30.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore

Purpose: The diabetic cohort (DC) was set up to study the determinants of complications in individuals with type 2 diabetes and examine the role of genetic, physiological and lifestyle factors in the development of complications in these individuals.

Participants: A total of 14 033 adult participants with type 2 diabetes were recruited from multiple public sector polyclinics and hospital outpatient clinics in Singapore between November 2004 and November 2010. The first round of follow-up was conducted for 4131 participants between 2012 and 2016; the second round of follow-up started in 2016 and is expected to end in 2021. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-036443DOI Listing

Falls in older people with diabetes: Identification of simple screening measures and explanatory risk factors.

Prim Care Diabetes 2020 May 27. Epub 2020 May 27.

Neuroscience Research Australia, UNSW, Randwick, Sydney, Australia.

Aims: To identify risk factors for falls in older people with diabetes mellitus (DM) and to develop a low-cost fall risk screening tool.

Methods: Older adults with DM (n = 103; age = 61.6 + 6. Read More

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http://dx.doi.org/10.1016/j.pcd.2020.05.006DOI Listing

Beneficial effects of ferulic acid alone and in combination with insulin in streptozotocin induced diabetic neuropathy in Sprague Dawley rats.

Life Sci 2020 May 27:117856. Epub 2020 May 27.

Pharmacology Division, University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh 160014, India. Electronic address:

Background: Ferulic acid (FA) is a phenolic phytochemical known to protect against various diabetic complications. However, its role in diabetic neuropathy is still unclear. The present study investigated the potential protective effects of FA alone and its combination with insulin against streptozotocin (STZ)-induced diabetic neuropathy in rats. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117856DOI Listing

Determinants of Treatment Response in Painful Diabetic Peripheral Neuropathy. A Combined Deep Sensory Phenotyping and Multi-modal Brain Magnetic Resonance Imaging Study.

Diabetes 2020 May 29. Epub 2020 May 29.

Department of Human Metabolism, University of Sheffield, Sheffield, UK

Painful diabetic polyneuropathy (DPN) is difficult to manage as treatment response is often varied. The primary aim of this study was to examine differences in pain phenotypes between responders and non-responders to intravenous lidocaine treatment using quantitative sensory testing. The secondary aim was to explore differences in brain structure and functional connectivity with treatment response. Read More

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http://dx.doi.org/10.2337/db20-0029DOI Listing

Relationship between diabetic neuropathic pain and comorbidity. Their impact on pain intensity, diabetes complications and quality of life in patients with type-2 diabetes mellitus.

Diabetes Res Clin Pract 2020 May 26:108236. Epub 2020 May 26.

The Observatory of Pain, University of Cádiz, Spain; Preventive Medicine and Public Health Area, University of Cádiz, Spain; Biomedical Research and Innovation Institute of Cádiz (INiBICA), Spain. Electronic address:

Objective: To compare cognitive function, mood and sleep status in patients with and without diabetic neuropathic pain (DNP) and their relationship with pain intensity, diabetes complications, and quality of life. To determine whether these relationships differ depending on the sensorial phenotype.

Methods: Cross-sectional study performed on patients with type-2 diabetes-mellitus and neuropathy. Read More

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http://dx.doi.org/10.1016/j.diabres.2020.108236DOI Listing

"It Gave Me Hope" Experiences of Diverse Safety Net Patients in a Group Acupuncture Intervention for Painful Diabetic Neuropathy.

Health Equity 2020 22;4(1):225-231. Epub 2020 May 22.

UCSF Osher Center for Integrative Medicine, UCSF, San Francisco, California, USA.

To explore the experiences of living with painful diabetic neuropathy (PDN) and with a group acupuncture intervention in a sample of low-income, diverse patients. We conducted a randomized clinical trial of a 12-week group acupuncture intervention for PDN. Data included validated measures of patient-reported outcomes, including pain and quality of life (QOL), as well as semistructured qualitative interviews about participants' experiences with PDN and the intervention. Read More

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http://dx.doi.org/10.1089/heq.2020.0004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247034PMC

Formononetin Ameliorates Diabetic Neuropathy by Increasing Expression of SIRT1 and NGF.

Chem Biodivers 2020 May 27. Epub 2020 May 27.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L.Mehta Road, Vile Parle (W), Mumbai, 400056, India.

Diabetic neuropathy is commonly observed complication in more than 50 % of type 2 diabetic patients. Histone deacetylases including SIRT1 have significant role to protect neuron from hyperglycemia induced damage. Formononetin (FMNT) is known for its effect to control hyperglycemia and also activate SIRT1. Read More

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http://dx.doi.org/10.1002/cbdv.202000162DOI Listing

The Association between Serum Uric Acid and Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus: A Multicenter Nationwide CrossSectional Study.

Korean J Fam Med 2020 May 20;41(3):189-194. Epub 2020 May 20.

Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.

Background: The role of uric acid in the development of diabetic peripheral neuropathy remains unclear. This study aimed to determine the association between uric acid and peripheral neuropathy among type 2 diabetes mellitus (T2DM) patients.

Methods: We conducted a nationwide cross-sectional study based on the diabetes and hypertension study of the Medical Research Network of the Consortium of Thai Medical Schools. Read More

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http://dx.doi.org/10.4082/kjfm.18.0205DOI Listing

The Effects of Tocotrienol-Rich Vitamin E (Tocovid) on Diabetic Neuropathy: A Phase II Randomized Controlled Trial.

Nutrients 2020 May 23;12(5). Epub 2020 May 23.

Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya 47500, Malaysia.

Chronic hyperglycemia increases oxidative stress, activates inflammatory pathways and reduces nerve growth factor (NGF) among diabetic patients, which contribute to development of diabetic peripheral neuropathy (DPN). Tocotrienol-Rich Vitamin E (Tocovid) possesses potent antioxidant and anti-inflammatory properties which are postulated to target these pathogeneses in order to ameliorate DPN. This study aims to evaluate the effects of Tocovid on nerve conduction parameters and serum biomarkers among diabetic patients. Read More

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http://dx.doi.org/10.3390/nu12051522DOI Listing

Acute Improvement in Intraoperative EMG During Common Fibular Nerve Decompression in Patients with Symptomatic Diabetic Sensorimotor Peripheral Neuropathy: EMG and Clinical Attribute Interrelations.

J Neurol Surg A Cent Eur Neurosurg 2020 May 26. Epub 2020 May 26.

Anderson Center for Nerve Pain, Fort Collins, Colorado, United States.

Study Aims:  Electromyographic (EMG) recordings of the fibularis longus and tibialis anterior muscles were performed intraoperatively during nerve decompression (ND) of the common fibular nerve (CFN) in patients with symptomatic diabetic sensorimotor peripheral neuropathy. Patient demographics and clinical attributes were compared against changes in EMG after ND and analyzed for possible correlations.

Methods:  Intraoperative changes in CFN EMG were analyzed for correlations against sex, age, body mass index (BMI), hemoglobin A1c (A1c), and type and duration of diabetes. Read More

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http://dx.doi.org/10.1055/s-0040-1701619DOI Listing

Optimised cushioning in diabetic footwear can significantly enhance their capacity to reduce plantar pressure.

Gait Posture 2020 May 17;79:244-250. Epub 2020 May 17.

Centre for Biomechanics and Rehabilitation Technologies, Staffordshire University, Stoke-on-Trent, United Kingdom; Faculty of Health Sciences, University of Malta, Msida, Malta.

Background: Plantar pressure reduction with the use of cushioning materials play an important role in the clinical management of the diabetic foot. Previous studies in people without diabetes have shown that appropriate selection of the stiffness of such materials can significantly enhance their capacity to reduce pressure. However the significance of optimised cushioning has not been yet assessed for people with diabetic foot syndrome. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.05.009DOI Listing

Estimands and missing data in clinical trials of chronic pain treatments: advances in design and analysis.

Pain 2020 May 22. Epub 2020 May 22.

Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, USA.

In clinical trials of treatments for chronic pain, the percentage of participants who withdraw early can be as high as 50%. Major reasons for early withdrawal in these studies include perceived lack of efficacy and adverse events. Commonly employed strategies for accommodating missing data include last observation carried forward, baseline observation carried forward, and more principled methods such as mixed model repeated measures and multiple imputation. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001937DOI Listing

Exploring MicroRNAs in Diabetic Chronic Cutaneous Ulcers: Regulatory Mechanisms and Therapeutic Potentials.

Br J Pharmacol 2020 May 25. Epub 2020 May 25.

Key Laboratory of Basic Pharmacology of Ministry of Education, China.

Diabetic chronic cutaneous ulcers (DCU) is one of the serious complications of diabetes mellitus, which mainly occurs in diabetic patients with peripheral neuropathy. Recent studies have indicated that microRNAs (miRNAs/miRs) and their target genes are essential regulators of cell physiology and pathology including biological processes that are involved in the regulation of diabetes and diabetes-related microvascular complications. In vivo and in vitro models have revealed that the expression of some miRNAs can be regulated in the inflammatory response, cell proliferation, and wound remodeling of DCU. Read More

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http://dx.doi.org/10.1111/bph.15139DOI Listing

Association of vitamin B deficiency in people with type 2 diabetes on metformin and without metformin: a multicenter study, Karachi, Pakistan.

BMJ Open Diabetes Res Care 2020 May;8(1)

Clinical Biochemistry and Psychopharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi, Pakistan.

Objective: To assess the prevalence of vitamin B deficiency in people with type 2 diabetes mellitus (T2DM) on metformin and without metformin.

Methodology: Between May 2018 and January 2019, this prospective multicenter observational study recruited participants from seven centers in four provinces of Pakistan (Sindh, Punjab, Baluchistan and Khyber Pakhtunkhwa). Participants with T2DM treated with metformin for >2 years and those not on metformin underwent assessment of hemoglobin, vitamin B, homocysteine and diabetic neuropathy (vibration perception threshold (VPT) >15V) and painful diabetic neuropathy (Douleur Neuropathique 4 (DN4) ≥4) and Diabetic Neuropathy Symptom (DNS) score ≥1. Read More

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http://dx.doi.org/10.1136/bmjdrc-2019-001151DOI Listing

Elderly individuals with diabetes and foot ulcer have a probability for healing despite extensive comorbidity and dependency.

Expert Rev Pharmacoecon Outcomes Res 2020 May 23. Epub 2020 May 23.

Skåne University Hospital , Department of Endocrinology, 214 21 Malmö Sweden.

Background: limited scientific evidence for prevention and treatment of diabetic foot ulcers in elderly with comorbidities.

Aim: explore patient-related factors and outcome in patients ≥75 years with diabetes and a foot ulcer.

Method: sub-analysis of consecutively presenting patients ≥75 years (N=1008) from a previous study on 2,480 patients with diabetes foot ulcer treated in a multidisciplinary system until healing. Read More

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http://dx.doi.org/10.1080/14737167.2020.1773804DOI Listing

Linear mixed-effects models for the analysis of high-density electromyography with application to diabetic peripheral neuropathy.

Med Biol Eng Comput 2020 May 24. Epub 2020 May 24.

Institute of Biomedical Engineering, Department of Electrical and Electronic Engineering, Federal University of Santa Catarina, Florianópolis, Brazil.

This article demonstrates the power and flexibility of linear mixed-effects models (LMEMs) to investigate high-density surface electromyography (HD-sEMG) signals. The potentiality of the model is illustrated by investigating the root mean squared value of HD-sEMG signals in the tibialis anterior muscle of healthy (n = 11) and individuals with diabetic peripheral neuropathy (n = 12). We started by presenting the limitations of traditional approaches by building a linear model with only fixed effects. Read More

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http://dx.doi.org/10.1007/s11517-020-02181-1DOI Listing

NADPH oxidase: A membrane-bound enzyme and its inhibitors in diabetic complications.

Eur J Pharmacol 2020 May 19:173206. Epub 2020 May 19.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V. L Mehta Road, Vile Parle (W), Mumbai, 400 056, India. Electronic address:

The human body has a mechanism for balancing the generation and neutralization of reactive oxygen species. The body is exposed to many agents that are responsible for the generation of reactive oxygen/nitrogen species, which leads to disruption of the balance between generation of these species and oxidative stress defence mechanisms. Diabetes is a chronic pathological condition associated with prolonged hyperglycaemia. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173206DOI Listing

Inverse Correlation Between Grip Strength and Serum Phosphorus: A Retrospective Observational Study in Japanese Elderly with Poorly Controlled Type 2 Diabetes.

Geriatrics (Basel) 2020 May 19;5(2). Epub 2020 May 19.

Department of Internal Medicine, Nihon University Hospital, Tokyo 101-8309, Japan.

The aim of this study was to investigate factors associated with sarcopenia among elderly patients with poorly controlled diabetes mellitus (DM). We retrospectively analyzed 41 patients with type 2 DM, aged ≥65 years who required diabetes education hospitalization. Patients were classified into two groups according to the presence or absence of a weakened hand grip, and clinical characteristics were compared. Read More

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http://dx.doi.org/10.3390/geriatrics5020033DOI Listing

Rapid glycemic regulation in poorly controlled patients living with diabetes, a new associated factor in the pathophysiology of Charcot's acute neuroarthropathy.

PLoS One 2020 21;15(5):e0233168. Epub 2020 May 21.

INSERM UMRS 1138, Cordeliers Research Center, Paris, France.

Objective: Aggressive antidiabetic therapy and rapid glycemic control are associated with diabetic neuropathy. Here we investigated if this is also the case for Charcot neuroarthropathy.

Research Design And Methods: HbA1c levels and other relevant data were extracted from medical databases of 44 cases of acute Charcot neuroarthropathy. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233168PLOS

Pharmacokinetics and Safety of Ranirestat in Patients With Hepatic Impairment.

J Clin Pharmacol 2020 May 21. Epub 2020 May 21.

Clinical Pharmacology Group, Clinical Research, Drug Development Division, Sumitomo Dainippon Pharma Co., Ltd., Tokyo, Japan.

Ranirestat is an aldose reductase inhibitor hypothesized to improve diabetic neuropathy. An open-label, single-dose, parallel-group study was conducted to compare pharmacokinetic (PK) characteristics of an oral dose of ranirestat across subjects with normal hepatic function and patients with mild and moderate hepatic impairment because ranirestat is expected to be used by patients with diabetes mellitus, possibly including those with hepatic impairment. To evaluate the necessity for dose adjustment, PK profiles and tolerability were studied at the dose of 40 mg, the expected optimal clinical dose in patients with diabetic neuropathy and normal hepatic function. Read More

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http://dx.doi.org/10.1002/jcph.1636DOI Listing

Hospitalization costs associated with diabetic foot ulcers treated by a multidisciplinary team in clinical practice. A retrospective study from southern Turkey.

Ann Ital Chir 2020 May 14;9. Epub 2020 May 14.

Purpose: Diabetic foot ulceration (DFU) is a common problem throughout the world and results in major economic consequences for the patients and country. We aim to describe the estimated cost of illness in patients with DFU in southern Turkey.

Methods: A total of 148 (F=55, M=93) patients with DFU were included in this retrospective study. Read More

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Fiberoptic Endoscopic Evaluation of Swallowing in Patients with Type 2 Diabetes Who Have Self-Reported Swallowing Difficulties.

Folia Phoniatr Logop 2020 May 20:1-9. Epub 2020 May 20.

Department of Otolaryngology, Faculty of Medicine, Gazi University, Ankara, Turkey.

Introduction: People with diabetes frequently have gastrointestinal problems and related deglutition disorders.

Objective: The aims of the present study are to determine the symptomatic swallowing complaints and to evaluate the functionality of oropharyngeal swallowing in patients with type 2 diabetes mellitus (T2DM) by using the Turkish Eating Assessment Tool-10 (T-EAT-10) and fiberoptic endoscopic evaluation of swallowing (FEES).

Methods: In this descriptive cross-sectional study, the T-EAT-10 questionnaire was completed by 121 patients with diabetes, and FEES was planned for each individual whose baseline score of the T-EAT-10 was ≥3. Read More

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http://dx.doi.org/10.1159/000507623DOI Listing

Nicotinamide riboside relieves paclitaxel-induced peripheral neuropathy and enhances suppression of tumor growth in tumor-bearing rats.

Pain 2020 May 15. Epub 2020 May 15.

Departments of Anesthesia, Pathology and Neuroscience and Pharmacology, The University of Iowa, Iowa City, IA 52242.

Nicotinamide riboside (NR) is a vitamin B3 precursor of NAD that blunts diabetic and chemotherapy-induced peripheral neuropathy in preclinical models. This study examined whether NR also blunts the loss of intraepidermal nerve fibers (IENF) induced by paclitaxel, which is associated with peripheral neuropathy. The work was conducted in female rats with N-methyl-nitrosourea (MNU)-induced tumors of the mammary gland to increase its translational relevance, and to assess the interaction of NR with paclitaxel and NR's effect on tumor growth. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001924DOI Listing

Hemichorea-Hemiballismus as an Unusual Presentation of Hyperosmolar Hyperglycemic Syndrome.

Am J Med Case Rep 2020 5;8(6):159-161. Epub 2020 Apr 5.

Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203 USA.

Diabetes mellitus can lead to a diverse array of systemic complications. Poorly managed hyperglycemia can result in serious neurological consequences ranging from peripheral neuropathy to seizures and coma. A rare neurologic disorder seen in acute decompensated type 2 diabetes mellitus (T2DM) is hemichorea-hemiballismus (HCHB). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236990PMC

Perforated Gangrenous Gallbladder in an Asymptomatic Patient.

Cureus 2020 Apr 18;12(4):e7728. Epub 2020 Apr 18.

Family Medicine, Louisiana State University Health Sciences Center, Shreveport, USA.

Acute cholecystitis or inflammation of the gallbladder is a common cause of hospitalizations. A percentage of those patients will progress to gangrenous cholecystitis and perforation. This medical emergency can lead to peritonitis, which has increased morbidity and mortality. Read More

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http://dx.doi.org/10.7759/cureus.7728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233968PMC

Advances with Long Non-Coding RNAs in Diabetic Peripheral Neuropathy.

Diabetes Metab Syndr Obes 2020 30;13:1429-1434. Epub 2020 Apr 30.

Department of Endocrinology, Jinshan Hospital, Fudan University, Shanghai, People's Republic of China.

Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs longer than 200 nucleotides, which are defined as transcripts. The lncRNAs are involved in regulating gene expression at epigenetic, transcriptional, and post-transcriptional levels. Recent studies have found that lncRNA is closely related to many diseases like neurological diseases, endocrine and metabolic disorders. Read More

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http://dx.doi.org/10.2147/DMSO.S249232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201007PMC

Organizational changes in diabetic foot care practices for patients at low and moderate risk after implementing a comprehensive foot care program in Alberta, Canada.

J Foot Ankle Res 2020 May 19;13(1):26. Epub 2020 May 19.

Diabetes, Obesity and Nutrition Strategic Clinical Network, Alberta Health Services, 10101 Southport Road, Calgary, Alberta, T2W 1S7, Canada.

Background: Neuropathy and vasculopathy can lead to costly and debilitating complications in people with diabetes. The purpose of this study was to evaluate, at an organizational level, uptake of practices included in a diabetic foot care clinical pathway and associated resources. This research focused on patients at low and moderate risk in Alberta, Canada between 2014 to 2019. Read More

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http://dx.doi.org/10.1186/s13047-020-00393-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236492PMC

Persistence of pregabalin treatment in Taiwan: a nation-wide population-based study.

J Headache Pain 2020 May 19;21(1):54. Epub 2020 May 19.

Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, No. 201, Sec. 2, Shi-Pai Road, Bei-Tou District, Taipei City, Taiwan, 11217.

Background: Pregabalin is approved for the treatment of neuropathic pain, fibromyalgia, and seizure disorders, although the pivotal trials were mostly carried out in Europe or North America. The prescribing patterns among different indications in Asia have rarely been explored.

Methods: This was a population-based retrospective cohort study based on the National Health Insurance Research Database in Taiwan. Read More

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http://dx.doi.org/10.1186/s10194-020-01123-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236209PMC

Clinician Assessment Tools for Patients with Diabetic Foot Disease: A Systematic Review.

J Clin Med 2020 May 15;9(5). Epub 2020 May 15.

Department of Physiotherapy, University of Málaga, Arquitecto Francisco Peñalosa, s/n. Ampliación campus de Teatinos, 29071 Málaga, Spain.

The amputation rate in patients with diabetes is 15 to 40 times higher than in patients without diabetes. To avoid major complications, the identification of high-risk in patients with diabetes through early assessment highlights as a crucial action. Clinician assessment tools are scales in which clinical examiners are specifically trained to make a correct judgment based on patient outcomes that helps to identify at-risk patients and monitor the intervention. Read More

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http://dx.doi.org/10.3390/jcm9051487DOI Listing

Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy and relieves hyperalgesia in diabetic rats.

Neuroreport 2020 May 15. Epub 2020 May 15.

Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.

The purpose of this study was to explore the role and mechanism of the PI3K/AKT/mTOR signaling pathway in painful diabetic neuropathy (PDN). The diabetes mellitus (DM) model was established by intraperitoneal injection of streptozocin into SD rats. After 3 weeks of modeling, the DM + LY group was treated with PI3K inhibitor, the DM + vehicle group was treated with DMSO, and the DM group was untreated. Read More

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http://dx.doi.org/10.1097/WNR.0000000000001461DOI Listing

Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy and relieves hyperalgesia in diabetic rats.

Neuroreport 2020 Jun;31(9):644-649

Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China.

The purpose of this study was to explore the role and mechanism of the PI3K/AKT/mTOR signaling pathway in painful diabetic neuropathy (PDN). The diabetes mellitus (DM) model was established by intraperitoneal injection of streptozocin into SD rats. After 3 weeks of modeling, the DM + LY group was treated with PI3K inhibitor, the DM + vehicle group was treated with DMSO, and the DM group was untreated. Read More

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http://dx.doi.org/10.1097/WNR.0000000000001461DOI Listing

Progressive Loss of Corneal Nerve Fibers and Sensitivity in Rats Modeling Obesity and Type 2 Diabetes Is Reversible with Omega-3 Fatty Acid Intervention: Supporting Cornea Analyses as a Marker for Peripheral Neuropathy and Treatment.

Diabetes Metab Syndr Obes 2020 24;13:1367-1384. Epub 2020 Apr 24.

Department of Internal Medicine, University of Iowa, Iowa City, IA, USA.

Purpose: To determine whether cornea nerve fiber density and/or corneal function are valid markers for early detection and treatment of peripheral neuropathy in rats modeling prediabetes and type 2 diabetes.

Methods: High-fat feeding combined without or with low-dose streptozotocin was used to create rat models for prediabetes and type 2 diabetes that were longitudinally studied for loss of structure and function of sensory nerves in the cornea and skin as well as nerve conduction velocity and vascular reactivity of epineurial arterioles. There were three time points examined in each of the three conditions with 12 rats per group. Read More

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http://dx.doi.org/10.2147/DMSO.S247571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189026PMC

Neurogenic tissue Nanotransfection in the Management of Cutaneous Diabetic Polyneuropathy.

Nanomedicine 2020 May 15:102220. Epub 2020 May 15.

Department of Surgery, Indiana Center for Regenerative Medicine and Engineering, Indiana University School of Medicine, Indianapolis, IN 46202. Electronic address:

This work rests on our recent report on the successful use of tissue nanotransfection (TNT) delivery of Ascl1, Brn2, and Myt1l (TNT) to directly convert skin fibroblasts into electrophysiologically active induced neuronal cells (iN) in vivo. Here we report that in addition to successful neurogenic conversion of cells, TNT caused neurotrophic enrichment of the skin stroma. Thus, we asked whether such neurotrophic milieu of the skin can be leveraged to rescue pre-existing nerve fibers under chronic diabetic conditions. Read More

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http://dx.doi.org/10.1016/j.nano.2020.102220DOI Listing

The diabetic foot ulcer.

Aust J Gen Pract 2020 05;49(5):250-255

FRACS (Vasc), Vascular Surgeon, Lismore Base Hospital, NSW.

Background: Diabetic foot ulcers are associated with significant morbidity and mortality and can subsequently lead to hospitalisation and lower limb amputation if not recognised and treated in a timely manner.

Objective: The aim of this article is to review the current evidence for preventing and managing diabetic foot ulcers, with the aim to increase clinicians' confidence in assessing and treating these complex medical presentations.

Discussion: All patients with diabetes should have an annual foot review by a general practitioner or podiatrist. Read More

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http://dx.doi.org/10.31128/AJGP-11-19-5161DOI Listing

Association of vitamin D and D with type 2 diabetes complications.

BMC Endocr Disord 2020 May 15;20(1):65. Epub 2020 May 15.

Weill Cornell Medicine-Qatar, PO Box 24144, Doha, Qatar.

Aims: Vitamin D measurement is a composite of vitamin D (25(OH)D) and D (25(OH)D) levels, and its deficiency is associated with the development of type 2 diabetes (T2DM) and diabetic complications; vitamin D deficiency may be treated with vitamin D supplements. This study was undertaken to determine if vitamin D and D levels differed between those with and without T2DM in this Middle Eastern population, and the relationship between diabetic microvascular complications and vitamin D and vitamin D levels in subjects with T2DM METHODS: Four hundred ninety-six Qatari subjects, 274 with and 222 without T2DM participated in the study. Plasma levels of total vitamin D and D were measured by LC-MS/MS analysis. Read More

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http://dx.doi.org/10.1186/s12902-020-00549-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227254PMC
May 2020
1.673 Impact Factor

Coriandrum sativum improve neuronal function via inhibition of oxidative/nitrosative stress and TNF-α in diabetic neuropathic rats.

J Ethnopharmacol 2020 May 12. Epub 2020 May 12.

M. M College of Pharmacy, M. M (Deemed to be University), Mullana, Ambala, Haryana, 133207, India. Electronic address:

Ethnophramacological Relevance: Coriandrum sativum L. is traditionally acknowledged for its use in inflammatory disorders, altered blood lipid levels, respiratory and digestive problems, etc. AIM OF THE STUDY: The present study investigates possible role of hydro-alcoholic extract of C. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112959DOI Listing

Glycaemic control for painful diabetic peripheral neuropathy is more than fasting plasma glucose and glycated haemoglobin.

Diabetes Metab 2020 May 12. Epub 2020 May 12.

Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Neurology, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Background: - The relationship between postprandial hyperglycaemia and diabetic peripheral neuropathy (DPN), whether painful or painless, has yet to be determined. Thus, the aim of this study was to investigate the relationship in patients with type 2 diabetes (T2D).

Methods: - This cross-sectional study was conducted in adults with T2D between January and October 2013. Read More

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http://dx.doi.org/10.1016/j.diabet.2020.04.004DOI Listing

Evolving concepts on the role of dyslipidemia, bioenergetics, and inflammation in the pathogenesis and treatment of diabetic peripheral neuropathy.

J Peripher Nerv Syst 2020 May 15. Epub 2020 May 15.

Department of Neurology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.

Diabetic peripheral neuropathy (DPN) is one of the most widespread and disabling neurological conditions, accounting for half of all neuropathy cases worldwide. Despite its high prevalence, no approved disease modifying therapies exist. There is now a growing body of evidence that DPN secondary to type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) represents different disease processes, with T2DM DPN best understood within the context of metabolic syndrome rather than hyperglycemia. Read More

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http://dx.doi.org/10.1111/jns.12387DOI Listing

Selected pathobiological features and principles of pharmacological pain management.

J Int Med Res 2020 May;48(5):300060520903653

Department of Periodontology and Oral Medicine, Sefako Makgatho University, Pretoria, South Africa.

Pain induced by inflammation and nerve injury arises from abnormal neural activity of primary afferent nociceptors in response to tissue damage, which causes long-term elevation of the sensitivity and responsiveness of spinal cord neurons. Inflammatory pain typically resolves following resolution of inflammation; however, nerve injury-either peripheral or central-may cause persistent neuropathic pain, which frequently manifests as hyperalgesia or allodynia. Neuralgias, malignant metastatic bone disease, and diabetic neuropathy are some of the conditions associated with severe, often unremitting chronic pain that is both physically and psychologically debilitating or disabling. Read More

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http://dx.doi.org/10.1177/0300060520903653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232056PMC

Escin alleviates peripheral neuropathy in streptozotocin induced diabetes in rats.

Life Sci 2020 May 11;254:117777. Epub 2020 May 11.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai - 400056, India.. Electronic address:

Aim: Inflammatory cascade and oxidative stress play a central role in diabetic peripheral neuropathy via activation of inflammatory cytokines. Escin has potent antioxidant and anti-inflammatory properties. Hence, the present study was conducted to evaluate the effect of escin on diabetic peripheral neuropathy in streptozotocin (STZ) induced diabetes in rats. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117777DOI Listing

Tarsal tunnel release restores sensations in sole for diabetic sensorimotor polyneuropathy.

J Clin Orthop Trauma 2020 May-Jun;11(3):442-447. Epub 2019 Aug 16.

Department of Surgery, NSCB Government Medical College, Jabalpur, MP, 482003, India.

Background: Diabetic sensorimotor polyneuropathy DSPN) is the commonest form of neuropathy. Loss of sensations in sole leads to diabetic foot ulcers (DFU) and its complications. Surgical decompression has been used in the treatment of diabetic peripheral neuropathy, however; its effectiveness has been questioned. Read More

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http://dx.doi.org/10.1016/j.jcot.2019.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211905PMC