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    Apical root-end filling with tricalcium silicate-based cement in a patient with diabetes mellitus: A case report.
    Vojnosanit Pregl 2016 12;73(12):1173-7
    Introduction: The material used for root-end filling has to be biocompatible with adjacent periapical tissue and to stimulate its regenerative processes. Tricalcium silicate cement (TSC), as a new dental material, shows good sealing properties with dentin, high compression strengths and better marginal adaptation than commonly used root-end filling materials. Although optimal postoperative healing of periapical tissues is mainly influenced by characteristics of end-root material used, it could sometimes be affected by the influence of systemic diseases, such as diabetes mellitus (DM). Read More

    Diabetic Peripheral Neuropathic Pain From the Perspective of Turkish Patients: A Qualitative Study.
    J Transcult Nurs 2018 Jan 1:1043659617753044. Epub 2018 Jan 1.
    2 Gazi University, Ankara, Turkey.
    Introduction: Diabetic peripheral neuropathy (DPN) affects almost 30% to 50% of patients with diabetes, 40% to 60% of whom suffer from diabetic peripheral neuropathic pain (DPNP). Few studies have focused on individual experiences of DPNP in patients with diabetes. The purpose of this qualitative study was to elucidate the effects of DPNP on daily life and individual feelings regarding living with DPNP from the perspective of Turkish patients. Read More

    Assessment of vestibular-evoked myogenic potentials and video head impulse test in type 2 diabetes mellitus patients with or without polyneuropathy.
    Eur Arch Otorhinolaryngol 2018 Jan 13. Epub 2018 Jan 13.
    Department of ENT, Kayseri Training and Research Hospital, Sanayi Mah. Atatürk Bulvarı Hastane Cad. No:78, 38010, Kayseri, Turkey.
    This study aimed to compare cervical vestibular-evoked myogenic potentials (cVEMP), ocular vestibular-evoked myogenic potentials (oVEMP) and video head impulse test (vHIT) results between patients with type 2 diabetes mellitus (DM) or diabetic polyneuropathy (DPN) and healthy controls to determine vestibular end-organ pathologies. The participants in the present study consisted of three groups: the type 2 DM group (n = 33 patients), the DPN group (n = 33 patients), and the age- and sex-matched control group (n = 35). Cervical VEMP, oVEMP and vHIT were performed for each participant in the study and test results were compared between the groups. Read More

    Risk Factors and Frequency of Ingrown Nails in Adult Diabetic Patients.
    J Foot Ankle Surg 2018 Jan 10. Epub 2018 Jan 10.
    Professor, Department of Neurology, Faculty of Medicine, Ankara University, Ankara, Turkey.
    The present study evaluated the properties of nails, frequency of ingrown nails in patients with type 2 diabetes mellitus (DM), risk factors for developing ingrown nails, and effect of diabetic polyneuropathy and vasculopathy on the development and outcome of ingrown nails. Our 6-month epidemiologic prospective study included 300 patients with type 2 DM attending a DM outpatient clinic for routine examinations. The general characteristics and foot changes of the study population were investigated. Read More

    Microvascular Outcomes of Pediatric-Onset Type 1 Diabetes Mellitus: A Single-Center Observational Case Reviews in Sana'a, Yemen.
    Clin Med Insights Endocrinol Diabetes 2018 3;11:1179551417749217. Epub 2018 Jan 3.
    Department of Medicine, Sana'a University, Sana'a, Yemen.
    Microvascular complications of pediatric-onset type 1 diabetes are common in low-income countries. In this study, we aimed at reviewing microvascular outcomes in 6 cases with type 1 diabetes over 14 to 31 years of follow-up. Severe proliferative diabetic retinopathy (PDR) and/or diabetic macular edema (maculopathy) (DME) and overt diabetic nephropathy (macroalbuminuria) were seen among 4 of 6 patients, whereas severe diabetic peripheral neuropathy with Charcot neuroarthropathy was seen in 1 patient only, who had the longest duration of follow-up. Read More

    Combination of high-fat/high-fructose diet and low-dose streptozotocin to model long-term type-2 diabetes complications.
    Sci Rep 2018 Jan 11;8(1):424. Epub 2018 Jan 11.
    Département de Pharmacologie et Physiologie/Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Québec, Canada.
    The epidemic of type 2 diabetes mellitus (T2DM) is fueled by added fructose consumption. Here, we thus combined high-fat/high-fructose diet, with multiple low-dose injections of streptozotocin (HF/HF/Stz) to emulate the long-term complications of T2DM. HF/HF/Stz rats, monitored over 56 weeks, exhibited metabolic dysfunctions associated with the different stages of the T2DM disease progression in humans: an early prediabetic phase characterized by an hyperinsulinemic period with modest dysglycemia, followed by a late stage of T2DM with frank hyperglycemia, normalization of insulinemia, marked dyslipidemia, hepatic fibrosis and pancreatic β-cell failure. Read More

    Whole-Mount Adult Ear Skin Imaging Reveals Defective Neuro-Vascular Branching Morphogenesis in Obese and Type 2 Diabetic Mouse Models.
    Sci Rep 2018 Jan 11;8(1):430. Epub 2018 Jan 11.
    Laboratory of Stem Cell and Neuro-Vascular Biology, Genetics and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD, 20892, USA.
    Obesity and type 2 diabetes are frequently associated with peripheral neuropathy. Though there are multiple methods for diagnosis and analysis of morphological changes of peripheral nerves and blood vessels, three-dimensional high-resolution imaging is necessary to appreciate the pathogenesis with an anatomically recognizable branching morphogenesis and patterning. Here we established a novel technique for whole-mount imaging of adult mouse ear skin to visualize branching morphogenesis and patterning of peripheral nerves and blood vessels. Read More

    High Prevalence of Obstructive Sleep Apnea among People with Type 2 Diabetes Mellitus in a Tertiary Care Center.
    J Assoc Physicians India 2017 Nov;65(11):38-42
    Senior Consultant and Director, Nithra Institute of Sleep Sciences, Chennai, Tamil Nadu.
    Purpose: Untreated obstructive sleep apnea (OSA) is a risk factor for hypertension and cardiac events, and is associated with increased mortality. Recent studies indicate that majority of people with type 2 diabetes also has OSA. The aim of this study was to assess the prevalence and severity of OSA and risk factors contributing to it among people with chronic and severe type 2 diabetes. Read More

    Glycemic control in type 2 diabetes: from medication nonadherence to residual vascular risk.
    Endocrine 2018 Jan 10. Epub 2018 Jan 10.
    Diabetes Unit, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Luigi Vanvitelli University, Naples, Italy.
    Despite the availability of many new treatment options for type 2 diabetes, the proportion of patients achieving the HbA1c target < 7.0% remains around 50%. We put forward the hypothesis that the unchanged HbA1c results, observed in the last decade in type 2 diabetes patients, are also a consequence of medication nonadherence and clinical inertia. Read More

    Nebivolol, a β-blocker abrogates streptozotocin-induced behavioral, biochemical, and neurophysiological deficit by attenuating oxidative-nitrosative stress: a possible target for the prevention of diabetic neuropathy.
    Naunyn Schmiedebergs Arch Pharmacol 2018 Jan 11. Epub 2018 Jan 11.
    Department of Pharmacology, Al-Ameen College of Pharmacy, Bengaluru, India.
    Metabolic abnormalities including hyperglycemia, hyperlipidemia, and oxidative-nitrosative stress are involved in the progression of diabetic neuropathy. In the present study, we targeted oxidative-nitrosative stress using nebivolol, a β1-receptor antagonist with vasodilator and antioxidant property, to evaluate its neuroprotective effect in streptozotocin-induced diabetic neuropathy in rats. Diabetic neuropathy develops within 4-6 weeks after administration of streptozotocin (55 mg/kg, i. Read More

    Heart rate variability: a new tool to predict complications in adult cardiac surgery.
    J Geriatr Cardiol 2017 Nov;14(11):662-668
    Department of Cardiovascular Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.
    Heart rate variability (HRV) refers to the variations between consecutive heartbeats, which depend on the continuous modulation of the sympathetic and parasympathetic branches of the autonomic nervous system. HRV has been shown to be effective as a predictor of risk after myocardial infarction and an early warning sign of diabetic neuropathy, and in the cardiology setting is now recognized to be a useful tool for risk-stratification after hospital admission and after discharge. Recent evidences suggest that HRV analysis might predict complications even in patients undergoing cardiac surgery, and the present review summarizes the importance of HRV analysis in adult cardiac surgery and the perspectives for HRV use in current clinical practice. Read More

    Alpha-mangostin attenuates diabetic nephropathy in association with suppression of acid sphingomyelianse and endoplasmic reticulum stress.
    Biochem Biophys Res Commun 2018 Jan 6. Epub 2018 Jan 6.
    Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. Electronic address:
    Aims: Diabetic nephropathy is a common complication of diabetes, but there are currently few treatment options. The aim of this study was to gain insight into the effect of alpha-mangostin on diabetic nephropathy and possible related mechanisms.

    Methods: Goto-Kakizaki rats were used as a diabetic model and received alpha-mangostin or desipramine treatment with normal saline as a control. Read More

    Annual Direct Medical Costs of Diabetic Foot Disease in Brazil: A Cost of Illness Study.
    Int J Environ Res Public Health 2018 Jan 8;15(1). Epub 2018 Jan 8.
    Internal Medicine Department, State University of Rio de Janeiro, Rio de Janeiro 20551-030, Brazil.
    The aim of this study was to estimate the annual costs for the treatment of diabetic foot disease (DFD) in Brazil. We conducted a cost-of-illness study of DFD in 2014, while considering the Brazilian Public Healthcare System (SUS) perspective. Direct medical costs of outpatient management and inpatient care were considered. Read More

    The corneal subbasal nerve plexus and thickness of the retinal layers in pediatric type 1 diabetes and matched controls.
    Sci Rep 2018 Jan 8;8(1):14. Epub 2018 Jan 8.
    Department of Pediatrics, Rostock University Medical Center, Rostock, Germany.
    Optical coherence tomography (OCT) of the retina and corneal confocal laser scanning microscopy (CLSM) of the subbasal nerve plexus (SBP) are noninvasive techniques for quantification of the ocular neurodegenerative changes in individuals with type 1 diabetes mellitus (T1DM). In adult T1DM patients these changes are hardly related to T1DM only. Instead, ageing and/or lifestyle associated comorbidities have to be considered as putative confounding variables. Read More

    Noninvasive Vascular Assessment of Lower Extremity Wounds in Diabetics: Are We Able to Predict Perfusion Deficits?
    Surg Technol Int 2017 Oct 12;31. Epub 2017 Oct 12.
    Division of Wound Healing, Hyperbaric Medicine, MedStar Georgetown University Hospital, Washington, DC.
    Vascular assessment of the lower extremity is a critical step in any patient presenting with lower extremity chronic wounds to predict the likelihood of healing and risk of amputation. This concept is vital in patients with diabetes due to their complex vascular anatomy and disease distribution. Three arteries supply the six angiosomes of the lower extremity (i. Read More

    Neural Mobilization Attenuates Mechanical Allodynia and Decreases Proinflammatory Cytokine Concentrations in Rats With Painful Diabetic Neuropathy.
    Phys Ther 2017 Dec 22. Epub 2017 Dec 22.
    Department of Physical Therapy, College of Medicine, National Cheng Kung University, No.1 Ta-Hsueh Road, Tainan, Taiwan.
    Background: Painful diabetic neuropathy (PDN) is a common complication in patients with diabetes. It is related to ischemic nerve damage and the increase in the levels of proinflammatory mediators, such as tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β). Neural mobilization may have the potential to alleviate PDN, but it has not yet been tested. Read More

    Parkinson's disease-linked DNAJC13 mutation aggravates alpha-synuclein-induced neurotoxicity through perturbation of endosomal trafficking.
    Hum Mol Genet 2018 Jan 3. Epub 2018 Jan 3.
    Division of Neurology, Department of Neuroscience & Sensory Organs, Tohoku University Graduate School of Medicine, Sendai 980-8574 Japan.
    Mutations in DNAJC13 gene have been linked to familial form of Parkinson's disease (PD) with Lewy pathology. DNAJC13 is an endosome-related protein and believed to regulate endosomal membrane trafficking. However, the mechanistic link between DNAJC13 mutation and α-synuclein (αSYN) pathology toward neurodegeneration remains poorly understood. Read More

    Oxidative stress-dependent MMP-13 activity underlies glucose neurotoxicity.
    J Diabetes Complications 2017 Dec 6. Epub 2017 Dec 6.
    Davis Center for Regenerative Biology and Medicine, MDI Biological Laboratory, Kathryn W. Davis Building 227, Old Bar Harbor Road, Salisbury Cove, ME 04672, USA. Electronic address:
    Background: A complication of diabetes is neuropathy, a condition of sensory axon degeneration that originates in the epidermis. The mechanisms remain unknown but reactive oxygen species (ROS) have been implicated in this condition. In this study, we assessed the role of ROS and a candidate downstream target, MMP-13 in glucose-induced sensory axon degeneration in zebrafish and mice. Read More

    Pathological role of lipid interaction with α-synuclein in Parkinson's disease.
    Neurochem Int 2018 Jan 3. Epub 2018 Jan 3.
    Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan; Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira 187-8502, Japan. Electronic address:
    Alpha-synuclein (αSyn) plays a central role in the pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In sporadic PD and DLB, normally harmless αSyn proteins without any mutations might gain toxic functions by unknown mechanisms. Thus, it is important to elucidate the factors promoting the toxic conversion of αSyn, towards understanding the pathogenesis of and developing disease-modifying therapies for PD and DLB. Read More

    Functional magnetic resonance imaging reveals differences in brain activation in response to thermal stimuli in diabetic patients with and without diabetic peripheral neuropathy.
    PLoS One 2018 5;13(1):e0190699. Epub 2018 Jan 5.
    Department of Anatomy, Histology and Embryology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
    Introduction: Diabetes affects both the peripheral and central nervous systems. The aim of this study was to explore the changes in brain activity in response to thermal stimuli in diabetic patients with and without diabetic peripheral neuropathy (DPN) using functional magnetic resonance imaging (fMRI).

    Methods: A total of 36 right-handed volunteers were enrolled: eight patients with Type-2 diabetes mellitus and DPN, 13 patients with Type-2 diabetes mellitus lacking DPN (NDPN patients), and 15 healthy volunteers (HV). Read More

    Metabolic control targets in Sudanese adults with type 1 diabetes: A population-based study.
    J Family Med Prim Care 2017 Apr-Jun;6(2):374-379
    Department of Medicine and HIV Metabolic Clinic, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire, UK.
    Background: Type 1 diabetes is a challenging metabolic disorder for health authorities in Sudan. The objective of this study was to assess the level of glycemic control and to determine the prevalence of dyslipidemia and complications among individuals with type 1 diabetes in Sudan.

    Materials And Methods: Individuals with type 1 diabetes, who were having the disease for at least 1 year, were invited to participate in this study. Read More

    Prevalence and determinants of diabetes distress in patients of diabetes mellitus in a tertiary care centre.
    Diabetes Metab Syndr 2017 Dec 22. Epub 2017 Dec 22.
    Department of Psychiatry, Pt. B.D.S. PGIMS, Rohtak, Haryana, India.
    Background: Patients of diabetes mellitus experience psychological difficulties associated with their disease which remains unrecognized involving several states related to coping with diabetes. Diabetes distress is a distinct condition which is often mistaken for depression and is related to adverse disease outcomes.

    Aims And Objective: To study the prevalence and predictors of diabetes distress in patients of Type 2 Diabetes mellitus (T2DM) in a tertiary care centre. Read More

    Perspectives on the impact of painful diabetic peripheral neuropathy in a multicultural population.
    Clin Diabetes Endocrinol 2017 28;3:12. Epub 2017 Dec 28.
    Palm Beach Neurological Center, Palm Beach Gardens, FL USA.
    Background: Since few studies have characterized painful diabetic peripheral neuropathy (pDPN) symptoms in multicultural populations, this study fielded a survey to better understand pDPN and its impact in African-American, Caucasian, and Hispanic populations.

    Methods: Kelton fielded a survey by phone or Internet, in English or Spanish, among adults with pDPN symptoms in the United States between August and October 2015; African-Americans and Hispanics were oversampled to achieve at least 500 subjects for each group. Patients were required to have been diagnosed with pDPN or score ≥ 3 on ID Pain validated screening tool. Read More

    mGluR2/3 activation of the SIRT1 axis preserves mitochondrial function in diabetic neuropathy.
    Ann Clin Transl Neurol 2017 Dec 1;4(12):844-858. Epub 2017 Nov 1.
    Department of NeurologyUniversity of Maryland School of MedicineBaltimoreMaryland21201.
    Objectives: There is a critical need to develop effective treatments for diabetic neuropathy. This study determined if a selective mGluR2/3 receptor agonist prevented or treated experimental diabetic peripheral neuropathy (DPN) through glutamate recycling and improved mitochondrial function.

    Methods: Adult male streptozotocin treated Sprague-Dawley rats with features of type 1 diabetes mellitus (T1DM) or Low Capacity Running (LCR) rats with insulin resistance or glucose intolerance were treated with 3 or 10 mg/kg/day LY379268. Read More

    Myocardial perfusion abnormalities in asymptomatic type 2 diabetic patients.
    J Saudi Heart Assoc 2018 Jan 19;30(1):3-8. Epub 2017 May 19.
    Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, KuwaitaKuwait.
    Objective: The prevalence of coronary artery disease (CAD) is high in patients with diabetes. Because ischemia and infarction are often silent in diabetic patients, diagnosis of CAD occurs inevitably late. It is essential to identify the presence of CAD in diabetic patients to start early treatment. Read More

    Lycium barbarum polysaccharide protects diabetic peripheral neuropathy by enhancing autophagy via mTOR/p70S6K inhibition in Streptozotocin-induced diabetic rats.
    J Chem Neuroanat 2017 Dec 30. Epub 2017 Dec 30.
    General Hospital of Ningxia Medical University, Yinchuan 750004, China; Department of Endocrinology, Qilu Hospital of Shandong University, Qingdao 266000, China. Electronic address:
    Lycium barbarum polysaccharide (LBP), the major active component of Lycium barbarum, has been found to be effective in the management of some diabetic complications. We evaluated the protective effect of LBP in diabetic peripheral neuropathy (DPN) and explored the possible mechanisms. We found that LBP mildly decreased blood glucose levels and partially rescued allodynia and hyperalgesia in the diabetes mellitus (DM) rats. Read More

    Oculomotor palsy in diabetics.
    J Fr Ophtalmol 2017 Dec 28. Epub 2017 Dec 28.
    Internal security forces hospital, Mohamed Fadhel Ben Achour street, Marsa Safsaf, Tunis, Tunisia.
    Introduction: Oculomotor palsy is one of the most frequent neuro-ophthalmologic complications of diabetic patients. It generates less interest in the literature than the other ocular manifestations. Our goal was to study the clinical, epidemiological, therapeutic and prognostic characteristics of oculomotor palsy in the diabetic. Read More

    Advantages of early diagnosis of diabetic neuropathy in the prevention of diabetic foot ulcers.
    Diabetes Res Clin Pract 2017 Dec 26. Epub 2017 Dec 26.
    Diabetic Foot Unit, Universidad Complutense de Madrid, Madrid, Spain. Electronic address:
    Aims: to evaluate the utility of the sudomotor function test (SFT) as a clinical tool in the Risk Stratification System of diabetic patients and to demonstrate the earlier detection of the risk of developing diabetic foot ulcers (DFU) compared to the standard clinical tests.

    Methods: prospective follow-up study on 263 patients enrolled consecutively over 3.5 years. Read More

    Neutrophil-lymphocyte Ratio is a Novel Reliable Predictor of Nephropathy, Retinopathy, and Coronary Artery Disease in Indians with Type-2 Diabetes.
    Indian J Endocrinol Metab 2017 Nov-Dec;21(6):864-870
    Department of Medicine, Gandhi Medical College, Bhopal, Madhya Pradesh, India.
    Background And Aims: Neutrophil-lymphocyte ratio (NLR) has been suggested to be a predictor of coronary artery disease (CAD), and end-organ damage in type-2 diabetes mellitus (T2DM). Similar data are lacking from Indians with T2DM. Hence, this study aimed to evaluate the role of NLR as a predictor of microvascular complications and CAD in T2DM. Read More

    Chinese herbal medicine TangBi Formula treatment of patients with type 2 diabetic distal symmetric polyneuropathy disease: study protocol for a randomized controlled trial.
    Trials 2017 Dec 29;18(1):631. Epub 2017 Dec 29.
    Guang'anmen Hospital, China Academy of Traditional Chinese Medical Sciences, No. 5, Bei xian ge Xicheng District, Beijing, 100053, China.
    Background: Diabetic distal symmetric polyneuropathy (DSPN) is one of the most common microvascular complications of diabetes mellitus, and it has become a major public health problem worldwide because of its high and increasing prevalence, morbidity, and disability rate. The current medications for DSPN are not entirely satisfactory. Preliminary studies indicated that the Chinese herbal TangBi Formula may alleviate signs and symptoms and improve the velocity of nerve conduction in patients with DSPN. Read More

    Pathophysiology of the underactive bladder.
    Investig Clin Urol 2017 Dec 13;58(Suppl 2):S82-S89. Epub 2017 Nov 13.
    Department of Continence Medicine, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
    Underactive bladder (UAB), which has been described as a symptom complex suggestive of detrusor underactivity, is usually characterized by prolonged urination time with or without a sensation of incomplete bladder emptying, usually with hesitancy, reduced sensation on filling, and slow stream often with storage symptoms. Several causes such as aging, bladder outlet obstruction, diabetes mellitus, neurologic disorders, and nervous injury to the spinal cord, cauda equine, and peripheral pelvic nerve have been assumed to be responsible for the development of UAB. Several contributing factors have been suggested in the pathophysiology of UAB, including myogenic failure, efferent and/or afferent dysfunctions, and central nervous system dysfunction. Read More

    Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.
    Pharmacogenet Genomics 2018 02;28(2):49-55
    Roswell Park Cancer Institute, Buffalo.
    Objective: Taxane containing chemotherapy extends survival for breast cancer patients. However, taxane-induced peripheral neuropathy (TIPN) cannot be predicted, prevented or effectively treated. Using genome-wide analyses, we sought to identify common risk variants for TIPN. Read More

    Role of inflammatory biomarker in diabetic peripheral neuropathy.
    J Diabetes Investig 2017 Dec 26. Epub 2017 Dec 26.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Hospital, Chonbuk National University Medical School, Jeonju, Korea.
    Diabetic peripheral neuropathy (DPN) is the most common chronic neurological complication of diabetes1 . Small and large peripheral nerve fibers may be involved in DPN. Large nerve fiber damage causes paresthesia, sensory loss, and muscle weakness and small nerve fiber damage is associated with pain, anesthesia, foot ulcer, and autonomic symptoms. Read More

    Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer): an international, multicentre, double-blind, randomised, controlled trial.
    Lancet Diabetes Endocrinol 2017 Dec 20. Epub 2017 Dec 20.
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy.
    Background: Diabetic foot ulcers are serious and challenging wounds associated with high risk of infection and lower-limb amputation. Ulcers are deemed neuroischaemic if peripheral neuropathy and peripheral artery disease are both present. No satisfactory treatment for neuroischaemic ulcers currently exists, and no evidence supports one particular dressing. Read More

    TGFβ signaling reinforces pericyte properties of the non-endocrine mouse pituitary cell line TtT/GF.
    Cell Tissue Res 2017 Dec 22. Epub 2017 Dec 22.
    Institute for Endocrinology, Meiji University, Kawasaki, Kanagawa, 214-8571, Japan.
    The non-endocrine TtT/GF mouse pituitary cell line was derived from radiothyroidectomy-induced pituitary adenoma. In addition to morphological characteristics, because the cells are S100β-positive, they have been accepted as a model of folliculostellate cells. However, our recent microarray analysis indicated that, in contrast to folliculostellate cells, TtT/GF cells might not be terminally differentiated, as they share some properties with stem/progenitor cells, vascular endothelial cells and pericytes. Read More

    Adenosine monophosphate-activated protein kinase modulation by berberine attenuates mitochondrial deficits and redox imbalance in experimental diabetic neuropathy.
    Neuropharmacology 2017 Dec 20;131:256-270. Epub 2017 Dec 20.
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Hyderabad, Bala Nagar, India. Electronic address:
    Adenosine monophosphate-activated protein kinase (AMPK) has been studied for its myriad metabolic and mitochondrial benefits in several chronic diseases. Recent studies have uncovered its therapeutic potential against mitochondrial dysfunction in cultured dorsal root ganglion (DRG) neurons isolated from streptozotocin (STZ) induced diabetic rats. The present study is aimed at evaluating the pharmacological efficacy of berberine (BRB), a natural AMPK activator against experimental diabetic neuropathy (DN) phenotype developed in STZ (55 mg/kg, i. Read More

    Effect of streptozotocin-induced diabetes on motor representations in the motor cortex and corticospinal tract in rats.
    Brain Res 2018 Feb 19;1680:115-126. Epub 2017 Dec 19.
    Department of Occupational Therapy, Kyorin University, Tokyo, Japan.
    Motor disorders in patients with diabetes are associated with diabetic peripheral neuropathy, which can lead to symptoms such as lower extremity weakness. However, it is unclear whether central motor system disorders can disrupt motor function in patients with diabetes. In a streptozotocin-induced rat model of type 1 diabetes, we used intracortical microstimulation to evaluate motor representations in the motor cortex, recorded antidromic motor cortex responses to spinal cord stimulation to evaluate the function of corticospinal tract (CST) axons, and used retrograde labeling to evaluate morphological alterations of CST neurons. Read More

    Methylglyoxal Requires AC1 and TRPA1 to Produce Pain and Spinal Neuron Activation.
    Front Neurosci 2017 6;11:679. Epub 2017 Dec 6.
    Department of Physiology, University of Kentucky, College of Medicine, Lexington, KY, United States.
    Methylglyoxal (MG) is a metabolite of glucose that may contribute to peripheral neuropathy and pain in diabetic patients. MG increases intracellular calcium in sensory neurons and produces behavioral nociception via the cation channel transient receptor potential ankyrin 1 (TRPA1). However, rigorous characterization of an animal model of methylglyoxal-evoked pain is needed, including testing whether methylglyoxal promotes negative pain affect. Read More

    [Vitamin B12 Deficiency in Type 2 Diabetes Mellitus].
    Acta Med Port 2017 Oct 31;30(10):719-726. Epub 2017 Oct 31.
    Serviço de Endocrinologia. Hospital de Egas Moniz. Centro Hospitalar de Lisboa Ocidental. Lisboa. Portugal.
    Introduction: Type 2 diabetes mellitus is a common disease, affecting up to 13.1% of the Portuguese population. In addition to the known micro and macrovascular complications, drug side effects constitute a major concern, leading to changes in the treatment guidelines, which favor safety over efficacy. Read More

    NaV channel variants in patients with painful and nonpainful peripheral neuropathy.
    Neurol Genet 2017 Dec 15;3(6):e207. Epub 2017 Dec 15.
    Department of Translational Biomarkers and Computational Genomics (S.W., S.P., R.G., S.K., J.T.), Bristol-Myers Squibb, Hopewell Site, Pennington, NJ; Department of Genetically Defined Diseases Discovery Biology (L.J.B.), Bristol-Myers Squibb, Wallingford, CT; Department of Innovative Clinical Development (I.Q., L.J.), Bristol-Myers Squibb, Lawrenceville, Princeton, NJ; Department of Neurology (S.A.-D.), Northwestern Medical Faculty Foundation, Chicago, IL; Department of Neurology (R.F.), Beth Israel Medical Center, Harvard School of Medicine, Boston, MA; Department of Neurology (D.M.S.), Icahn School of Medicine at Mount Sinai Medical Center, New York, NY; Department of Neurology (A.G.S.), University of Utah School of Medicine, Salt Lake City, UT; Department of Neurology (A.H.), Johns Hopkins University, Baltimore, MD. S.P. is currently affiliated with Biocon Bristol-Myers Squibb Research Center, Bangalore, India.
    Objective: To examine the incidence of nonsynonymous missense variants in SCN9A (NaV1.7), SCN10A (NaV1.8), and SCN11A (NaV1. Read More

    Efficacy of a new microvibration sensation measurement device at detecting diabetic peripheral neuropathy using a newly devised finger method.
    J Gen Fam Med 2017 Aug 13;18(4):155-161. Epub 2017 Apr 13.
    Department of NeuropsychiatrySchool of MedicineKagawa UniversityMiki, KitaKagawaJapan.
    To investigate the efficacy of the finger method using a new microvibration sensation measurement device in the evaluation of diabetic peripheral neuropathy (DPN). A cross-sectional study of 52 type 2 diabetic outpatients was performed. Patients were evaluated for DPN using American Diabetes Association (ADA) criteria, Michigan Neuropathy Screening Instrument, and the finger method. Read More

    Randomized Trial of the Effect of Mindfulness-Based Stress Reduction on Pain-Related Disability, Pain Intensity, Health-Related Quality of Life, and A1C in Patients With Painful Diabetic Peripheral Neuropathy.
    Clin Diabetes 2017 Dec;35(5):294-304
    Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
    IN BRIEF Painful diabetic peripheral neuropathy (PDPN) has a large negative impact on patients' physical and mental functioning, and pharmacological therapies rarely provide more than partial relief. Mindfulness-based stress reduction (MBSR) is a group psychosocial intervention that was developed for patients with chronic illness who were not responding to existing medical treatments. This study tested the effects of community-based MBSR courses for patients with PDPN. Read More

    Antiallodynic and antihyperalgesic activity of new 3,3-diphenyl-propionamides with anticonvulsant activity in models of pain in mice.
    Eur J Pharmacol 2017 Dec 17;821:39-48. Epub 2017 Dec 17.
    Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland.
    Anticonvulsant drugs are used to treat a wide range of non-epileptic conditions, including chronic pain. The aim of the present experiments was to examine analgesic activity of three new 3,3-diphenyl-propionamides, which had previously demonstrated anticonvulsant activity in the MES (maximal electroshock seizure), scPTZ (subcutaneous pentylenetetrazole) and/or 6Hz (psychomotor seizure) tests in mice. Antinociceptive activity was examined in mouse models of acute pain (the hot plate test) and tonic pain (the formalin test) in mice. Read More

    Corneal and Retinal Neuronal Degeneration in Early Stages of Diabetic Retinopathy.
    Invest Ophthalmol Vis Sci 2017 Dec;58(14):6365-6373
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
    Purpose: To examine the neuronal structural integrity of cornea and retina as markers for neuronal degeneration in nonproliferative diabetic retinopathy (NPDR).

    Methods: Participants were recruited from the broader Brisbane community, Queensland, Australia. Two hundred forty-one participants (187 with diabetes and 54 nondiabetic controls) were examined. Read More

    Effects of Immunocytokine Combined with Cattle Encephalon Glycoside and Ignotin on CTGF, HO-1 and NT-3 in Patients with Type 2 Diabetic Peripheral Neuropathy.
    Iran J Public Health 2017 Dec;46(12):1632-1638
    People's Hospital of Rizhaolanshan, Rizhao, Shandong, PR China.
    Background: This study was designed to explore the correlation of connective tissue growth factor (CTGF), heme oxygenase (HO-1), neurotrophic factors (NT-3) with type 2 diabetic peripheral neuropathy, as well as the changes after immune cytokine alone and combined with cattleencephalon glycoside and ignotin treatment.

    Methods: Seventy-six patients with type 2 diabetes and peripheral neuropathy charged into People's Hospital of Rizhaolanshan, China from 2014-2016 were selected. The severity of neuropathy was evaluated by TCSS. Read More

    Effects of stevia on synaptic plasticity and NADPH oxidase level of CNS in conditions of metabolic disorders caused by fructose.
    BMC Complement Altern Med 2017 Dec 19;17(1):540. Epub 2017 Dec 19.
    H. Buniatian Institute of Biochemistry NAS RA, 5/1 P.Sevag str, 0014, Yerevan, Armenia.
    Background: Excess dietary fructose intake associated with metabolic syndrome and insulin resistance and increased risk of developing type 2 diabetes. Previous animal studies have reported that diabetic animals have significantly impaired behavioural and cognitive functions, pathological synaptic function and impaired expression of glutamate receptors. Correction of the antioxidant status of laboratory rodents largely prevents the development of fructose-induced plurimetabolic changes in the nervous system. Read More

    Reversible Secondary Osteolysis in Diabetic Foot Infection.
    J Am Podiatr Med Assoc 2017 Nov;107(6):538-540
    Osteolysis, caused by active resorption of bone matrix by osteoclasts, can be primary or can develop secondary to a variety of disease processes. An elevated level of inflammatory cytokines in the local milieu and increased blood flow secondary to infection or autonomic neuropathy stimulate the osteoclasts and cause bone loss in the diabetic foot. Charcot's neuroarthropathy and osteomyelitis are well-known foot complications of diabetes, and secondary osteolysis has largely been underappreciated and, hence, underreported. Read More

    Pharmacodynamics and Pharmacokinetics of Lidocaine in a Rodent Model of Diabetic Neuropathy.
    Anesthesiology 2017 Dec 15. Epub 2017 Dec 15.
    From the Department of Anesthesiology and Laboratory of Experimental Anesthesiology and Intensive Care (LEICA) (W.t.H., M.W.H., J.H., S.P., P.L.); Department of Nuclear Medicine (K.d.B., H.J.V.), Cardiology (A.O.V., H.L.T.), Anatomy, Embryology and Physiology (A.O.V.), and Neurology (C.V.), Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands; Department of Anesthesiology and Intensive Care Medicine, Trauma Hospital, Graz, Austria (M.R.); Department of Anesthesiology, University of Heidelberg, Heidelberg, Germany (S.P.) and Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (P.L.).
    Background: Clinical and experimental data show that peripheral nerve blocks last longer in the presence of diabetic neuropathy. This may occur because diabetic nerve fibers are more sensitive to local anesthetics or because the local anesthetic concentration decreases more slowly in the diabetic nerve. The aim of this study was to investigate both hypotheses in a rodent model of neuropathy secondary to type 2 diabetes. Read More

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