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    Interventions for Neuropathic Pain: An Overview of Systematic Reviews.
    Anesth Analg 2017 Aug;125(2):643-652
    From the Departments of *Anesthesiology and Intensive Care and †Pediatrics, University Hospital Center Split, Split, Croatia; ‡Agency for Quality and Accreditation in Health Care and Social Welfare, Zagreb, Croatia; §Laboratory for Pain Research, Department of Anatomy, Histology and Embryology, University of Split School of Medicine, Split, Croatia; ∥Department of Radiology, University Hospital Center Split, Split, Croatia; and ¶Agency for Medicinal Products and Medical Devices, Zagreb, Croatia.
    Numerous interventions for neuropathic pain (NeuP) are available, but its treatment remains unsatisfactory. We systematically summarized evidence from systematic reviews (SRs) of randomized controlled trials on interventions for NeuP. Five electronic databases were searched up to March 2015. Read More

    Glycaemic control and the risk of hospitalisation for infection in patients with type 2 diabetes: Hong Kong Diabetes Registry.
    Diabetes Metab Res Rev 2017 Jul 21. Epub 2017 Jul 21.
    Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, China.
    Background: Infection occurs more commonly in diabetic compared to general population and is an under-recognised but important morbidity in patients with diabetes. We examined the impact of glycaemic control on hospitalisation for infection in a large prospective cohort of Chinese adults with type 2 diabetes.

    Methods: Between July 1994 and June 2014, 22,846 patients with type 2 diabetes underwent detailed assessment of metabolic control and diabetes complications. Read More

    Anemia: an independent risk factor of diabetic peripheral neuropathy in type 2 diabetic patients.
    Acta Diabetol 2017 Jul 21. Epub 2017 Jul 21.
    Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Youyi Road No. 1, Yuzhong District, Chongqing, 400016, China.
    Aims: Recently, the association between anemia and diabetic microvascular complications has been studied. Diabetic peripheral neuropathy (DPN) is also a common complication of type 2 diabetes mellitus (T2DM), while the relationship between anemia and DPN is rarely investigated. The aim of this study is to evaluate the association between anemia and DPN in T2DM. Read More

    Cardiac Arrest Following Drug Abuse with Intravenous Tapentadol: Case Report and Literature Review.
    Am J Case Rep 2017 Jul 21;18:817-821. Epub 2017 Jul 21.
    Division of Critical Care Medicine, New York Presbyterian-Lawrence Hospital Center Affiliated with Columbia University College of Physician and Surgeons, Bronxville, NY, USA.
    BACKGROUND Tapentadol is a centrally acting opioid analgesic, with a dual mode of action, as a norepinephrine reuptake inhibitor and an agonist of the μ-opioid receptor (MOR). Tapentadol is used for the management of musculoskeletal pain, and neuropathic pain associated with diabetic peripheral neuropathy. CASE REPORT A 32-year-old woman attended hospital for evaluation of an intractable headache. Read More

    Integrating data from randomized controlled trials and observational studies to predict the response to pregabalin in patients with painful diabetic peripheral neuropathy.
    BMC Med Res Methodol 2017 Jul 20;17(1):113. Epub 2017 Jul 20.
    Pfizer Inc, 235 E 42nd St, New York, NY, 10017, USA.
    Background: More patient-specific medical care is expected as more is learned about variations in patient responses to medical treatments. Analytical tools enable insights by linking treatment responses from different types of studies, such as randomized controlled trials (RCTs) and observational studies. Given the importance of evidence from both types of studies, our goal was to integrate these types of data into a single predictive platform to help predict response to pregabalin in individual patients with painful diabetic peripheral neuropathy (pDPN). Read More

    [Association of diabetic retinopathy with diabetic peripheral neuropathy in type 2 diabetic patients: the Beijing Desheng Diabetic Eye Disease Study].
    Zhonghua Yan Ke Za Zhi 2017 Jul;53(7):509-513
    Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
    Objective: To determine the prevalence of diabetic retinopathy (DR) and diabetic peripheral neuropathy (DPN) in the Beijing Desheng Diabetic Eye Disease Study cohort and to investigate the association between DR and DPN. Methods: Cross-sectional study in a type 2 diabetic cohort. Questionnaires were collected and physical examinations were performed. Read More

    Efficacy and safety of pregabalin for painful diabetic peripheral neuropathy in a population of Chinese patients: a randomized, placebo-controlled trial.
    J Diabetes 2017 Jul 20. Epub 2017 Jul 20.
    Chinese PLA General Hospital, Beijing.
    Background: Limited information exists on the efficacy of pregabalin in Chinese patients with diabetic peripheral neuropathy (pDPN).

    Methods: An 11-week, double-blind, placebo-controlled trial in Chinese pDPN patients randomized (1:1) to pregabalin 300 mg/day or placebo. Primary efficacy endpoint was change from baseline in mean daily pain score (0 = no pain;10 = worst possible pain). Read More

    Mechanisms of the analgesic effect of calcitonin on chronic pain by alteration of receptor or channel expression.
    Mol Pain 2017 Jan-Dec;13:1744806917720316
    2 Graduate School of Health Sciences, Kumamoto Health Science University, Kumamoto, Japan.
    The polypeptide hormone calcitonin is well known clinically for its ability to relieve osteoporotic back pain and neuropathic pain such as spinal canal stenosis, diabetic neuropathy, chemotherapy-induced neuropathy, and complex regional pain syndrome. Because the analgesic effects of calcitonin have a broad range, the underlying mechanisms of pain relief by calcitonin are largely unknown. However, recent studies using several types of chronic pain models combined with various methods have been gradually clarifying the mechanism. Read More

    L-Arginine supplementation prevents allodynia and hyperalgesia in painful diabetic neuropathic rats by normalizing plasma nitric oxide concentration and increasing plasma agmatine concentration.
    Eur J Nutr 2017 Jul 19. Epub 2017 Jul 19.
    INSERM, Neuro-Dol, Université Clermont Auvergne, 63000, Clermont-Ferrand, France.
    Purpose: Neuropathic pain is a common diabetic complication. It is characterized by symptoms of spontaneous and stimulus-evoked pain including hyperalgesia and allodynia. L-Arginine is a common precursor of many metabolites of biological interest, in particular, nitric oxide (NO), ornithine, and hence polyamines. Read More

    Vascular complications in diabetes: old messages, new thoughts.
    Diabetologia 2017 Jul 19. Epub 2017 Jul 19.
    Glycation and Diabetes, Mater Research Institute - Translational Research Institute, The University of Queensland, 37 Kent Street, Woolloongabba, Brisbane, QLD, 4102, Australia.
    In parallel with the growing diabetes pandemic, there is an increasing burden of micro- and macrovascular complications, occurring in the majority of patients. The identification of a number of synergistic accelerators of disease, providing therapeutic pathways, has stabilised the incidence of complications in most western nations. However, the primary instigators of diabetic complications and, thus, prevention strategies, remain elusive. Read More

    Synthesis and diabetic neuropathic pain-alleviating effects of 2N-(pyrazol-3-yl)methylbenzo[d]isothiazole-1,1-dioxide derivatives.
    Bioorg Med Chem 2017 Jul 8. Epub 2017 Jul 8.
    Center for Neuro-Medicine, Brain Science Institute, Korea Institutes of Science and Technology (KIST), Seoul 02792, Republic of Korea; Division of Bio-Medical Sciences & Technology, KIST School, Korea University of Science and Technology (UST), Gajungro 217, Youseong-gu, Daejeon 305-350, Republic of Korea. Electronic address:
    A novel series of fused-benzensulfonamide 2-N-(pyrazol-3-yl)methylbenzo[d]isothiazole-1,1-dioxide derivatives was designed and synthesized as metabolically stable T-type calcium channel inhibitors. Several compounds, 9, 10, and 17, displayed potent T-type channel inhibitory activity. Among them, compounds 10 and 17 showed good metabolic stability in human liver microsomes, and low hERG channel and CYP450 inhibition. Read More

    Diagnostic utility of corneal confocal microscopy and intra-epidermal nerve fibre density in diabetic neuropathy.
    PLoS One 2017 18;12(7):e0180175. Epub 2017 Jul 18.
    Division of Diabetes, Endocrinology and Gastroenterology, Institute of Human Development, University of Manchester and the Manchester Royal Infirmary, Central Manchester Hospital Foundation Trust, Manchester, United Kingdom.
    Objectives: Corneal confocal microscopy (CCM) is a rapid, non-invasive, reproducible technique that quantifies small nerve fibres. We have compared the diagnostic capability of CCM against a range of established measures of nerve damage in patients with diabetic neuropathy.

    Methods: In this cross sectional study, thirty subjects with Type 1 diabetes without neuropathy (T1DM), thirty one T1DM subjects with neuropathy (DSPN) and twenty seven non-diabetic healthy control subjects underwent detailed assessment of neuropathic symptoms and neurologic deficits, quantitative sensory testing (QST), electrophysiology, skin biopsy and corneal confocal microscopy (CCM). Read More

    Regional anesthesia in diabetic peripheral neuropathy.
    Curr Opin Anaesthesiol 2017 Jul 15. Epub 2017 Jul 15.
    aDepartment of Anesthesiology, Academic Medical Center, University of Amsterdam, The Netherlands bDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    Purpose Of Review: The aim of this review is to summarize recent relevant literature regarding regional anesthesia in the diabetic neuropathic patient and formulate recommendations for clinical practice.

    Recent Findings: Diabetic neuropathic nerves, but not nerves of diabetic patients per se, exhibit complex functional changes. As a result, they seem more sensitive to local anesthetics, and are more difficult to stimulate. Read More

    Bacteriology Of Diabetic Foot In Tertiary Care Hospital; Frequency, Antibiotic Susceptibility And Risk Factors.
    J Ayub Med Coll Abbottabad 2017 Apr-Jun;29(2):234-240
    Department of Medicine, Rawal Institute of Health Sciences, Islamabad, Pakistan.
    Background: Diabetic foot being one of the frequent and disabling complications of diabetes. In view of widespread regional variation in causative organisms and antimicrobial susceptibility, the current study aimed to determine frequency of causative organisms, their antimicrobial susceptibility and associated risk factors.

    Methods: This descriptive cross-sectional study was conducted in 6 months' duration at dept. Read More

    Association between Hemoglobin Levels and Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes: A Cross-Sectional Study Using Electronic Health Records.
    J Diabetes Res 2017 21;2017:2835981. Epub 2017 Jun 21.
    Department of Endocrinology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
    Objective: To investigate the relationship between hemoglobin levels and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM).

    Methods: 1511 patients with T2DM were included in the study. DPN was diagnosed based on symptoms, signs, and laboratory tests. Read More

    Structured lifestyle intervention in patients with the metabolic syndrome mitigates oxidative stress but fails to improve measures of cardiovascular autonomic neuropathy.
    J Diabetes Complications 2017 May 2. Epub 2017 May 2.
    Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, United States. Electronic address:
    Aims: To assess the role of oxidative stress in mediating adverse outcomes in metabolic syndrome (MetS) and resultant cardiovascular autonomic neuropathy (CAN), and to evaluate the effects of lifestyle interventions on measures of oxidative stress and CAN in subjects with MetS.

    Methods: Pilot study in 25 non-diabetic subjects with MetS (age 49±10years, 76% females) participating in a 24-week lifestyle intervention (supervised aerobic exercise/Mediterranean diet), and 25 age-matched healthy controls. CAN was assessed by cardiovascular reflex tests, heart rate variability (HRV) and PET imaging with sympathetic analog [(11)C] meta-hydroxyephedrine ([(11)C]HED). Read More

    Differences in the daily activity of patients with diabetic foot ulcers compared to controls in their free-living environments.
    Int Wound J 2017 Jul 13. Epub 2017 Jul 13.
    Department of Podiatry, Metro North Hospital & Health Service, Brisbane, Australia.
    The aims of our study were to investigate multiple daily activity outcomes in patients with diabetic foot ulcers (DFU) compared to diabetic peripheral neuropathy (DPN) and diabetes (DM) controls in their free-living environments. We examined daily activity outcomes of 30 patients with DFU, 23 DPN and 20 DM. All patients wore a validated multi-sensor device for > 5 days (>22 hours per day) to measure their daily activity outcomes: steps, energy expenditure (kJ), average metabolic equivalent tasks (METs), physical activity (>3·0 METs) duration and energy expenditure, lying duration, sleep duration and sleep quality. Read More

    Barriers and enablers to proper diabetic foot care amongst community dwellers in an Asian population: a qualitative study.
    Ann Transl Med 2017 Jun;5(12):254
    Department of Orthopaedic Surgery, Ng Teng Fong General Hospital, Singapore.
    Background: Diabetic foot complications are common within Asian populations. They arise due to poor diabetic control and foot care. In this study, we aimed to identify the causes for proper and improper diabetic foot care. Read More

    Acute Fulminant Uremic Neuropathy Following Coronary Angiography Mimicking Guillain-Barre Syndrome.
    Heart Views 2017 Apr-Jun;18(2):62-63
    Department of Cardiology, JLN Hospital, Ajmer, Rajasthan, India.
    A 55-year-old diabetic woman suffered a posterior wall ST-elevation myocardial infarction. She developed contrast-induced nephropathy following coronary angiography. Acute fulminant uremic neuropathy was precipitated which initially mimicked Guillan-Barre Syndrome, hence reported. Read More

    The effect of ambient temperature on type-2-diabetes: case-crossover analysis of 4+ million GP consultations across England.
    Environ Health 2017 Jul 12;16(1):73. Epub 2017 Jul 12.
    University of Exeter Medical School, Truro, UK.
    Background: Given the double jeopardy of global increases in rates of obesity and climate change, it is increasingly important to recognise the dangers posed to diabetic patients during periods of extreme weather. We aimed to characterise the associations between ambient temperature and general medical practitioner consultations made by a cohort of type-2 diabetic patients. Evidence on the effects of temperature variation in the primary care setting is currently limited. Read More

    Direct medical cost associated with diabetic retinopathy severity in type 2 diabetes in Singapore.
    PLoS One 2017 10;12(7):e0180949. Epub 2017 Jul 10.
    Department of Medicine, Khoo Teck Puat Hospital, Singapore, Republic of Singapore.
    Diabetic retinopathy (DR) is a leading cause of vision-loss globally among type 2 diabetes (T2DM) patients. Information on the economic burden of DR in Singapore is limited. We aim to identify the total annual direct medical costs of DR at different stages, and to examine factors influencing the costs. Read More

    The induction of the transcription factor Nrf2 enhances the antinociceptive effects of delta-opioid receptors in diabetic mice.
    PLoS One 2017 10;12(7):e0180998. Epub 2017 Jul 10.
    Grup de Neurofarmacologia Molecular, Institut d'Investigació Biomèdica Sant Pau, Barcelona, Spain.
    The involvement of heme oxygenase 1 (HO-1) in the modulation of the antinociceptive effects of opioids in type 1 diabetes has been demonstrated but the role played by the transcription factor Nrf2 in the regulation of painful neuropathy and in the effects and expression of δ-opioid receptors (DOR) in type 2 diabetes, has not been studied. In male BKS.Cg-m+/+Leprdb/J (db/db) mice, the anti-allodynic effects produced by a Nrf2 transcription factor activator, sulforaphane (SFN) administered alone and combined with two DOR agonists, [d-Pen(2),d-Pen(5)]-Enkephalin (DPDPE) and (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N diethylbenzamide (SNC-80), were evaluated. Read More

    Optimisation of rocker sole footwear for prevention of first plantar ulcer: comparison of group-optimised and individually-selected footwear designs.
    J Foot Ankle Res 2017 6;10:27. Epub 2017 Jul 6.
    Centre for Health Sciences Research, University of Salford, Salford, Manchester, M6 6PU UK.
    Background: Appropriate footwear for individuals with diabetes but no ulceration history could reduce the risk of first ulceration. However, individuals who deem themselves at low risk are unlikely to seek out bespoke footwear which is personalised. Therefore, our primary aim was to investigate whether group-optimised footwear designs, which could be prefabricated and delivered in a retail setting, could achieve appropriate pressure reduction, or whether footwear selection must be on a patient-by-patient basis. Read More

    Clinical approach to diabetic Cardiomiopathy: a review of human studies.
    Curr Med Chem 2017 Jul 5. Epub 2017 Jul 5.
    Department of Biomedical Experimental and Clinical Sciences, SOD Diabetology, University of Florence and Careggi University Hospital, Florence. Italy.
    Background: Diabetic Cardiomiopathy (DC) has been defined as a distinct entity characterized by the presence of diastolic or systolic cardiac dysfunction in a diabetic patient in the absence of other causes for Cardiomiopathy, such as coronary artery disease (CAD), hypertension (HTN), or valvular heart disease. Diabetes affects every organ in the body and cardiovascular disease accounts for two-thirds of the mortality in the diabetic population. Diabetes-related heart disease occurs in the form of coronary artery disease (CAD), cardiac autonomic neuropathy or DC. Read More

    Effectiveness and feasibility of nailfold microcirculation test to screen for diabetic peripheral neuropathy.
    Diabetes Res Clin Pract 2017 Jun 13;131:42-48. Epub 2017 Jun 13.
    Department of Endocrinology, Zunyi Medical College Affiliated Shenzhen Longgang Central Hospital, Shenzhen 518116, Guangdong, China. Electronic address:
    Aims: The nailfold microcirculation index (MI) is a non-invasive, objective, and highly sensitive blood capillary detection method. This study evaluated the diagnostic efficiency of the nailfold MI relative to the more subjective vibration perception threshold (VPT) examination for early diagnostic screening of diabetic peripheral neuropathy (DPN).

    Methods: From February 2015 to February 2016, 227 diabetes mellitus patients and 39 healthy individuals were enrolled. Read More

    Diphenyleneiodonium Mitigates Bupivacaine-Induced Sciatic Nerve Damage in a Diabetic Neuropathy Rat Model by Attenuating Oxidative Stress.
    Anesth Analg 2017 Aug;125(2):653-661
    From the *Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China; and †Department of Anesthesiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
    Background: Increased oxidative stress has been linked to local anesthetic-induced nerve injury in a diabetic neuropathy (DN) rat model. The current study explores the effects of diphenyleneiodonium (DPI) chloride, an NADPH oxidase (NOX) inhibitor, on bupivacaine-induced sciatic nerve injury in DN rats.

    Methods: A rat DN model was established through high-fat diet feeding and streptozotocin injection. Read More

    miR‑199a‑3p is involved in the pathogenesis and progression of diabetic neuropathy through downregulation of SerpinE2.
    Mol Med Rep 2017 Sep 28;16(3):2417-2424. Epub 2017 Jun 28.
    Department of Pain Management, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China.
    The present study aimed to investigate the expression status of miRNA‑199a‑3p in patients with diabetic neuropathy (DN) and the mechanism by which this miRNA is involved in the genesis of DN. The expression of miRNA‑199a‑3p in plasma of peripheral blood was compared between patients with diabetes and a family history of diabetes and control volunteers by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR); in 60 diabetes patients, 45 (75%) demosntrated upregulated miR‑199a‑3p expression compared with control volunteer plasma. RT‑qPCR was also used to detect miRNA‑199a‑3p expression in paired lower limb skin tissues from 30 patients with DN and 20 control volunteers; miR‑199a‑3p expression in patients with DN was significantly higher than in the control group. Read More

    A Systematic Review of Treatment of Painful Diabetic Neuropathy by Pain Phenotype versus Treatment Based on Medical Comorbidities.
    Front Neurol 2017 20;8:285. Epub 2017 Jun 20.
    Endocrinology Division, Diabetes Center of Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, São Paulo, Brazil.
    Background: Painful diabetic neuropathy (PDN) is a serious, polymorphic, and prevalent complication of diabetes mellitus. Most PDN treatment guidelines recommend a selection of drugs based on patient comorbidities. Despite the large numbers of medications available, most randomized clinical trials (RCTs) conducted so far have yielded unsatisfactory outcomes. Read More

    Recent advances in polymer-based wound dressings for the treatment of diabetic foot ulcer: an overview of state-of-the-art.
    Curr Drug Targets 2017 Jul 4. Epub 2017 Jul 4.
    Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Raiwind Road Lahore, Punjab. Pakistan.
    Diabetic foot ulcers (DFUs) are the chronic, non-healing complications of diabetic mellitus which compels a significant burden to the patients and the healthcare system. Peripheral vascular disease, diabetic neuropathy, and abnormal cellular and cytokine/chemokine activity are among the prime players which exacerbate the severity and prevent wound reapir. Unlike acute wounds, DFUs impose a substantial challenge to the conventional wound dressings and demand the development of novel and advanced wound healing modalities. Read More

    Prevalence of and Risk Factors for Diabetic Peripheral Neuropathy in Youth With Type 1 and Type 2 Diabetes: SEARCH for Diabetes in Youth Study.
    Diabetes Care 2017 Jul 3. Epub 2017 Jul 3.
    Department of Neurology, University of Michigan, Ann Arbor, MI
    Objective: We assessed the prevalence of and risk factors for diabetic peripheral neuropathy (DPN) in youth with type 1 diabetes (T1D) and type 2 diabetes (T2D) enrolled in the SEARCH for Diabetes in Youth study.

    Research Design And Methods: The Michigan Neuropathy Screening Instrument (MNSI) was used to assess DPN in 1,734 youth with T1D (age 18 ± 4 years, T1D duration 7.2 ± 1. Read More

    Dietary intake habits and prevalence of nocturia in Japanese patients with type 2 diabetes mellitus.
    J Diabetes Investig 2017 Jul 1. Epub 2017 Jul 1.
    Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.
    Aims/introduction: No reports have been published on the association between dietary intake habits and nocturia in the diabetes population. We therefore estimate this issue among Japanese patients with diabetes mellitus.

    Materials And Methods: Study subjects in the present study were 785 Japanese patients with type 2 diabetes mellitus. Read More

    Integrated cardiovascular/respiratory control in type 1 diabetes evidences functional imbalance: Possible role of hypoxia.
    Int J Cardiol 2017 Jun 15. Epub 2017 Jun 15.
    Department of Internal Medicine, University of Pavia, Pavia, Italy; Folkhälsan Institute of Genetics, Folkhälsan Research Center, University of Helsinki, Helsinki, Finland. Electronic address:
    Background: Cardiovascular (baroreflex) and respiratory (chemoreflex) control mechanisms were studied separately in diabetes, but their reciprocal interaction (well known for diseases like heart failure) had never been comprehensively assessed. We hypothesized that prevalent autonomic neuropathy would depress both reflexes, whereas prevalent autonomic imbalance through sympathetic activation would depress the baroreflex but enhance the chemoreflexes.

    Methods: In 46 type-1 diabetic subjects (7. Read More

    Ischemic monomelic neuropathy: a long-term follow-up of two cases.
    J Vasc Access 2017 Jun 20. Epub 2017 Jun 20.
     Division of Nephrology and Hypertension, Department of Medicine, Albany Medical College, Albany, NY - USA.
    Introduction: Ischemic monomelic neuropathy (IMN) is the most dreaded complication of an arteriovenous access creation. While uncommon, it can lead to pain, paresthesia or/and hand weakness. Creation of an arteriovenous connection causing a sudden diversion of blood away from the nerves can lead to ischemic injury to the neural tissue and cause IMN. Read More

    Ethnic differences in the +405 and -460 vascular endothelial growth factor polymorphisms and peripheral neuropathy in patients with diabetes residing in a North London, community in the United Kingdom.
    BMC Neurol 2017 Jun 29;17(1):125. Epub 2017 Jun 29.
    Department of Cellular and Molecular Medicine, St. Georges University of London, London, UK.
    Background: There are marked ethnic differences in the susceptibility to the long-term diabetic vascular complications including sensory neuropathy. The vascular endothelial growth factor (VEGF) +405 (C/G) and -460 (T/C) polymorphisms are associated with retinopathy and possibly with nephropathy, however no information is available on their relationship with peripheral neuropathy. Therefore, we examined the prevalence of these VEGF genotypes in a multi-ethnic cohort of patients with diabetes and their relationship with evident peripheral diabetic neuropathy. Read More

    α9-containing nicotinic acetylcholine receptors and the modulation of pain.
    Br J Pharmacol 2017 Jun 29. Epub 2017 Jun 29.
    Departments of Biology, University of Utah, Salt Lake City, Utah, USA.
    Neuropathic pain is a complex and debilitating syndrome for which there are few effective pharmacological treatments. Opioid-based medications are initially effective for acute pain but tolerance to their analgesic effects quickly develops and long-term use often leads to physical dependence and addiction. Furthermore, neuropathic pain is generally resistant to non-steroidal anti-inflammatory drugs. Read More

    A Retrospective Review of Adverse Events Related to Diabetic Foot Ulcers.
    Ostomy Wound Manage 2017 Jun;63(6):30-33
    James A. Haley Veterans' Hospital, Tampa, FL.
    The risk of adverse events (AEs) such as infection and amputation related to diabetic foot ulcers (DFUs) has been studied, but less is known about rate of other AEs such as falls. As part of a quality improvement project, AEs in veterans with diabetes mellitus (DM) with and without a DFU were examined. Demographic data including ICD-9 codes, AEs, and comorbidities for all patients with a diagnosis of DM and/or DFU treated between 2009 and 2014 at the James A. Read More

    Anxiety affects disability and quality of life in patients with painful diabetic neuropathy.
    Eur J Pain 2017 Jun 27. Epub 2017 Jun 27.
    Adelante Centre of Expertise in Rehabilitation and Audiology, Hoensbroek, The Netherlands.
    Background: Painful diabetic neuropathy (PDN) is known to negatively affect psychosocial functioning as expressed by enhanced levels of anxiety and depression. The aim of this study was to specify diabetes and pain-related fears.

    Methods: This questionnaire-based cross-sectional study included 154 patients with PDN (mean age 65. Read More

    Optical coherence tomography predicts 4-year incident diabetic neuropathy.
    Ophthalmic Physiol Opt 2017 Jul;37(4):451-459
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
    Purpose: To examine the capability of optical coherence tomography-derived retinal thickness measures in detecting 4-year incident diabetic peripheral neuropathy (DPN).

    Methods: 145 eyes of 145 participants with diabetes but no DPN at baseline were examined for incident DPN. HbA1c levels, nephropathy, neuropathy (DPN), cardiovascular measures, and various retinal thickness measures were examined at baseline and after 4 years. Read More

    The Relationship between Cardiovascular Autonomic Dysfunction and Ocular Abnormality in Chinese T2DM.
    J Diabetes Res 2017 1;2017:7125760. Epub 2017 Jun 1.
    Department of Endocrinology, The 306th Teaching Hospital of People's Liberation Army, Peking University, Beijing, China.
    Objective: This study aims to explore the relationship between autonomic nerve dysfunction-assessed by cardiovascular autonomic neuropathy risk score (CAN-RS)-and ocular abnormality in Chinese type 2 diabetes mellitus (T2DM).

    Method: This is a cross-sectional study. A total of 335 subjects with T2DM were enrolled. Read More

    Clinical application of ghrelin for diabetic peripheral neuropathy.
    Endocr J 2017 ;64(Suppl.):S53-S57
    Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan.
    Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, and its progression significantly worsens the patient's quality of life. Although several drugs are available for DPN, all of these provide only symptomatic relief. We investigated the therapeutic effects of ghrelin for DPN, based on its various physiological functions. Read More

    Introduction of the DiaGene study: clinical characteristics, pathophysiology and determinants of vascular complications of type 2 diabetes.
    Diabetol Metab Syndr 2017 19;9:47. Epub 2017 Jun 19.
    Department of Internal Medicine, Erasmus Medical Center, P. O. Box 2040, 3000 CA Rotterdam, The Netherlands.
    Background: Type 2 diabetes is a major healthcare problem. Glucose-, lipid-, and blood pressure-lowering strategies decrease the risk of micro- and macrovascular complications. However, a substantial residual risk remains. Read More

    Decreasing incidence of foot ulcer among patients with type 1 and type 2 diabetes in the period 2001-2014.
    Diabetes Res Clin Pract 2017 Jun 13;130:221-228. Epub 2017 Jun 13.
    Steno Diabetes Center Copenhagen, Niels Steensensvej 2, 2820 Gentofte, Denmark; Department of Dermatology and Copenhagen Woundhealing Center, Copenhagen Wound Healing Center, Copenhagen University Hospital Bispebjerg, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark.
    Aim: Diabetic foot ulcer (DFU) is a serious complication to diabetes. The aim was to study the incidence of first DFU among patients with type 1 (T1DM) and type 2 diabetes (T2DM), stratified according to etiology: neuropathic, neuro-ischemic or ischemic, over a period of 14years (2001-2014).

    Methods: DFU incidence rates were calculated from electronic patient record data from patients with T1DM and complicated T2DM from a large specialized diabetes hospital with a multidisciplinary foot clinic in Denmark. Read More

    Effect of GLP-1 receptor agonist on gastrointestinal tract motility and residue rates as evaluated by capsule endoscopy.
    Diabetes Metab 2017 Jun 22. Epub 2017 Jun 22.
    Department of Pulmonary Medicine, Dokkyo Medical University Nikko Medical Center, 632, Takatoku Nikkoshi, 321-2593 Tochigi, Japan.
    Aim: This study evaluated the effects of a glucagon-like peptide-1 receptor agonist on gastrointestinal (GI) tract motility and residue rates by examining GI transit time and lumen using capsule endoscopy.

    Material And Methods: GI motility and lumen were assessed by capsule endoscopy before and after liraglutide administration in 14 patients with type 2 diabetes mellitus (T2DM).

    Results: Gastric transit time in the group with diabetic neuropathy (DN) was 1:12:36±1:04:30h before liraglutide administration and 0:48:40±0:32:52h after administration (nonsignificant difference, P=0. Read More

    [Relationship between carotid plaque and diabetic retinopathy in type 2 diabetes mellitus patients].
    Zhonghua Yi Xue Za Zhi 2017 Jun;97(24):1871-1874
    Department of Ophthalmology, Beijing Airport Hospital, Beijing 101318, China.
    Objective: To analyze the relevant factors for diabetic retinopathy. Methods: The data of type 2 diabetes mellitus patients undergoing general examination and ophthalmology specialist consultation were collected from the inpatients of Department of Endocrinology in Beijing Airport Hospital between 2013 and 2016, and the relevant factors of diabetic retinopathy were retrospectively analyzed. Results: A total of 432 cases were analyzed, including 168 cases of non-diabetic retinopathy and 264 cases of diabetic retinopathy. Read More

    Postprandial hypotension in neurological disorders: systematic review and meta-analysis.
    Clin Auton Res 2017 Jun 24. Epub 2017 Jun 24.
    School of Medicine, University of Zagreb, Zagreb, Croatia.
    Purpose: Postprandial hypotension (PPH) has been associated with increased risk of syncope, falls, stroke, angina and mortality. As the majority of patients with PPH are asymptomatic, the diagnosis is often overlooked. The aim of this study was to perform a systematic review and meta-analysis of available scientific evidence on the likelihood of PPH in neurological diseases. Read More

    Expression of High-Mobility Group Box 1 Protein (HMGB1) and Toll-Like Receptor 9 (TLR9) in Retinas of Diabetic Rats.
    Med Sci Monit 2017 Jun 25;23:3115-3122. Epub 2017 Jun 25.
    Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China (mainland).
    BACKGROUND Diabetic retinopathy (DR) and diabetic optic neuropathy are important complications of diabetes mellitus (DM) which can lead to blindness in diabetic patients. Recent studies showed that chronic low-grade inflammation is thought to be one of the important pathophysiological mechanisms in the occurrence and development of DR and diabetes optic neuropathy. This study explored the expressions of inflammatory factors HMGB-1 and TLR9. Read More

    Injury-induced gp130 cytokine signaling in peripheral ganglia is reduced in diabetes mellitus.
    Exp Neurol 2017 Jun 20;296:1-15. Epub 2017 Jun 20.
    Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA. Electronic address:
    Neuropathy is a major diabetic complication. While the mechanism of this neuropathy is not well understood, it is believed to result in part from deficient nerve regeneration. Work from our laboratory established that gp130 family of cytokines are induced in animals after axonal injury and are involved in the induction of regeneration-associated genes (RAGs) and in the conditioning lesion response. Read More

    Association of apolipoprotein-CIII (apoC-III), endothelium-dependent vasodilation and peripheral neuropathy in a multi-ethnic population with type 2 diabetes.
    Metabolism 2017 Jul 2;72:75-82. Epub 2017 Apr 2.
    Clinical Research Unit, Khoo Teck Puat Hospital, Singapore 768828; Diabetes Centre, Khoo Teck Puat Hospital, Singapore 768828; Division of Endocrinology, Department of Medicine, Khoo Teck Puat Hospital, Singapore 768828. Electronic address:
    Background: Diabetic peripheral neuropathy (DPN) is a common complication of Type 2 diabetes (T2D). Apart from hyperglycemia, its pathogenesis is poorly understood. Apolipoprotein-CIII (apoC-III) associated with triglyceride metabolism, is a risk factor for cardiovascular disease. Read More

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