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    Mechanical Allodynia Predicts Better Outcome of Surgical Decompression for Painful Diabetic Peripheral Neuropathy.
    J Reconstr Microsurg 2018 Mar 22. Epub 2018 Mar 22.
    Department of Neurosurgery, XinHua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Republic of China.
    Background:  To determine the role of mechanical allodynia (MA) in predicting good surgical outcome for painful diabetic peripheral neuropathy (DPN).

    Methods:  A series of 192 patients with painful DPN were collected in this study, with 148 surgical patients and 44 patients in the control group. Both groups were further divided into subgroups based on the presence of MA on admission. Read More

    A Randomized, Double-Blind Study of the Effects of a Sustained Release Formulation of Sodium Nitrite (SR-nitrite) on Patients with Diabetic Neuropathy.
    Pain Physician 2018 Mar;21(2):179-190
    A T Still University, Kirksville, MO.
    Background: Sodium nitrite has been reported to be effective in reducing chronic peripheral pain.

    Objectives: To evaluate the safety and efficacy of 40 and 80 mg, BID, of an oral sustained release formulation of sodium nitrite (SR-nitrite) in patients suffering from diabetic neuropathy, and to determine whether SR-nitrite would reduce the frequency of headaches reported previously by subjects receiving the same doses of an immediate release formulation.

    Study Design: Phase II, single-center, randomized, double-blind, placebo controlled clinical trial. Read More

    Binding characteristics and analgesic effects of mirogabalin, a novel ligand for the αδ subunit of voltage-gated calcium channels.
    J Pharmacol Exp Ther 2018 Mar 21. Epub 2018 Mar 21.
    Daiichi Sankyo Co., Ltd.
    Mirogabalin ([(1,5,6)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid), a novel ligand for the αδ subunit of voltage-gated calcium channels, is being developed to treat pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Read More

    Working party approved by the French Society of Anaesthesia and Intensive Care Medicine (SFAR) and the French Society for the study of Diabetes (SFD).
    Anaesth Crit Care Pain Med 2018 Mar 17. Epub 2018 Mar 17.
    Department of surgical anaesthesia and intensive care, South Paris university hospital (AP-HP), Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 le Kremlin, Bicêtre, France.
    In diabetic patients undergoing surgery, we recommend assessing glycaemic control preoperatively by assessing glycated haemoglobin (HbA1c) levels and recent capillary blood sugar (glucose) levels, and to adjust any treatments accordingly before surgery, paying particular attention to specific complications of diabetes. Gastroparesis creates a risk of stasis and aspiration of gastric content at induction of anaesthesia requiring the use of a rapid sequence induction technique. Cardiac involvement can be divided into several types. Read More

    Low serum bilirubin levels contribute to the presence and progression of distal symmetrical polyneuropathy in Chinese patients with type 2 diabetes.
    Diabetes Metab 2018 Feb 22. Epub 2018 Feb 22.
    Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, No. 321, Zhongshan Road, Nanjing, Jiangsu 210008, China. Electronic address:
    Aim: To investigate the association between serum bilirubin and distal symmetrical polyneuropathy (DSPN) in Chinese patients with type 2 diabetes (T2D).

    Methods: A total of 1800 inpatients with T2D (including 68 with 1-year follow-ups) were consecutively enrolled between June 2014 and March 2017. DSPN was diagnosed according to criteria recommended by the Toronto Diabetic Neuropathy Expert Group in 2010. Read More

    Danhong Injection Alleviates Mechanical Allodynia via Inhibiting ERK1/2 Activation and Elevates BDNF Level in Sciatic Nerve in Diabetic Rat.
    Evid Based Complement Alternat Med 2018 14;2018:5798453. Epub 2018 Jan 14.
    Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China.
    Danhong injection (DHI) has been widely used in China for cardiocerebrovascular diseases treatments. And in this study, we demonstrated the therapeutic effect of DHI on experimental diabetic neuropathy for the first time.. Read More

    Quercetin in association with moderate exercise training attenuates injuries induced by experimental diabetes in sciatic nerves.
    J Physiol Pharmacol 2017 Dec;68(6):877-886
    Department of Physiology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.
    Diabetic neuropathy (DN) is a frequent, serious and debilitating chronic complication of diabetes mellitus (DM). Hyperglycemia, oxidative and nitrosative stress are involved in causing nerve damage in several animals, humans and experimental models of diabetes. This study was designed to investigate the synergistic cumulative neuroprotective effect of quercetin administration and moderate exercise training on sciatic nerves injuries in streptozotocin (STZ)-diabetic rats. Read More

    Transcriptional networks of progressive diabetic peripheral neuropathy in the db/db mouse model of type 2 diabetes: An inflammatory story.
    Exp Neurol 2018 Mar 14. Epub 2018 Mar 14.
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109-2200, USA. Electronic address:
    Diabetic peripheral neuropathy is the most common complication of diabetes and a source of considerable morbidity. Numerous molecular pathways are linked to neuropathic progression, but it is unclear whether these pathways are altered throughout the course of disease. Moreover, the methods by which these molecular pathways are analyzed can produce significantly different results; as such it is often unclear whether previously published pathways are viable targets for novel therapeutic approaches. Read More

    Corneal nerve fiber size adds utility to the diagnosis and assessment of therapeutic response in patients with small fiber neuropathy.
    Sci Rep 2018 Mar 16;8(1):4734. Epub 2018 Mar 16.
    Weill Cornell Medicine-Qatar, Doha, Qatar.
    Small fiber neuropathy (SFN) is a common feature of many inflammatory diseases, often presenting with pain and disability. SFN is diagnosed using symptoms, thermal threshold testing, and intra-epidermal nerve fiber quantification. Corneal confocal microscopy (CCM) is an ophthalmic imaging technique which non-invasively quantifies corneal nerve fiber (CNF) density, branch density and length, and has comparable diagnostic and superior ability to identify nerve regeneration compared to skin biopsy. Read More

    CD40-mediated HIF-1α expression underlying microangiopathy in diabetic nerve pathology.
    Dis Model Mech 2018 Mar 16. Epub 2018 Mar 16.
    Department of Anatomy and Cell Biology, National Taiwan University, Taipei 10051, Taiwan
    To understand the pathology and molecular signatures of microangiopathy in diabetic neuropathy, we systemically and quantitatively examined the morphometry of microvascular and nerve pathologies of sural nerves. In the endoneurium of diabetic nerves, prominent microangiopathy evidenced by reduced capillary luminal area, increased capillary basement membrane thickness, and increased proportion of fibrin(+) blood vessels. Furthermore, capillary basement membrane thickness and the proportion of fibrin(+) blood vessels were correlated with small myelinated fiber density in diabetic nerves. Read More

    Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies.
    Medicina (Kaunas) 2018 Feb 27. Epub 2018 Feb 27.
    Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta (FUNAAB), Abeokuta, Nigeria.
    Glycemic homeostasis refers to glucose balance or control within circulation in living organisms. It is normally and largely compromised in diabetes. The compromise when exacerbated, leads to several complications including retinopathy, nephropathy and neuropathy which are collectively known as diabetic complications and are the principal actors in co-morbidity and eventual mortality often associated with diabetes. Read More

    White blood cell subpopulation changes and prevalence of neutropenia among Arab diabetic patients attending Dasman Diabetes Institute in Kuwait.
    PLoS One 2018 16;13(3):e0193920. Epub 2018 Mar 16.
    Dasman Diabetes Institute, Sharq, Kuwait.
    Background: The effects of diabetes mellitus on the differential white blood cell count are not widely studied in the Arab populations. The objective of this cross-sectional, retrospective study is to assess the influence of chronic diabetes mellitus on white blood cell counts, absolute neutrophil (ANC) and lymphocyte counts (ALC) as well as the prevalence of benign ethnic neutropenia among Arabs attending the Dasman Diabetes Institute (DDI) in Kuwait.

    Methods And Findings: 1,580 out of 5,200 patients registered in the DDI database qualified for our study. Read More

    Urine levels of 5-aminoimidazole-4-carboxamide riboside (AICAR) in patients with type 2 diabetes.
    Acta Diabetol 2018 Mar 15. Epub 2018 Mar 15.
    Dietmar-Hopp Metabolic Center, Center for Child and Adolescent Medicine, University of Heidelberg, Heidelberg, Germany.
    Aims: 5-Aminoimidazole-4-carboxamide riboside (AICAR) is an endogenous activator of AMPK, a central regulator of energy homeostasis. Loss and/or reduction of AMPK signaling plays an important role in the development of insulin resistance in type 2 diabetes. The loss of AMPK in diabetes could be due to a loss of AICAR. Read More

    [Transthyretin Familial Amyloid Polyneuropathy - Disease Profile of a Multisystem Disorder].
    Dtsch Med Wochenschr 2018 Mar 15;143(6):427-430. Epub 2018 Mar 15.
    Transthyretin-related Familial Amyloid Polyneuropathy (ATTR Amyloidosis, former FAP, here called TTR-FAP) is a rare, progressive autosomal dominant inherited amyloid disease ending fatal within 5 - 15 years after final diagnosis. TTR-FAP is caused by mutations of transthyretin (TTR), which forms amyloid fibrils affecting peripheral and autonomic nerves, the heart and other organs. Due to the phenotypic heterogeneity and partly not specific enough clinical symptoms, diagnosis of TTR-FAP can be complicated. Read More

    Managing Postural Hypotension in Diabetic Autonomic Dysfunction When Adrenergic Drugs are Contraindicated: Case Report and Review of Literature.
    Cureus 2018 Jan 8;10(1):e2039. Epub 2018 Jan 8.
    Department of Medicine, Jinnah Hospital, Allama Iqbal Medical College, Lahore.
    Postural hypotension, as a manifestation of autonomic neuropathy is a very sinister long-term debilitating complication of diabetes, is usually irreversible and tough to manage with medications. The treatment of this condition following the standard treatment protocols can be contraindicated in the patients with underlying heart conditions. We report the case of a patient at our hospital who presented with full-blown symptomatic dysautonomia secondary to long-standing diabetes, with bedside testing positive for autonomic dysfunction. Read More

    Thyroid Status in Patients with Type 2 Diabetes Attending a Tertiary Care Hospital in Eastern India.
    Indian J Endocrinol Metab 2018 Jan-Feb;22(1):112-115
    Department of Endocrinology, IPGMER, Kolkata, West Bengal, India.
    Objective: Type 2 diabetes mellitus and thyroid dysfunction (TD) are two major public health endocrine problem, but the prevalence of TD and iodine status in patients with T2 DM in India is less studied. The study objective was to explore the prevalence of TD and to evaluate iodine health in type 2 diabetes patients attending a tertiary care center in Eastern India.

    Methods: Consecutive 100 patients with diabetes attending outpatient department were evaluated clinically and biochemically (thyrotropin [TSH], free thyroxine, anti-TPO antibody, and urinary iodine). Read More

    Normative Values for Electrochemical Skin Conductance Measurements for Quantitative Assessment of Sudomotor Function in Healthy Indian Adults.
    Indian J Endocrinol Metab 2018 Jan-Feb;22(1):57-61
    Medical Division, Impeto Medical, Paris, France.
    Context: Electrochemical skin conductance (ESC) test is a widely accepted objective technique for quantitatively assessing sudomotor dysfunction, which is one of the earliest-detected neurophysiologic abnormalities in diabetic patients with distal symmetric polyneuropathy.

    Aims: This study aimed to provide normative data for ESC values among healthy Indian participants and assess the potential influence of age, sex, and body mass index (BMI) on ESC measurements.

    Settings And Design: A sample of 217 healthy participants aged 18-75 years were recruited and assessed for parameters including age, gender, BMI, and ESC measurements of the hands and feet. Read More

    Reducing CXCR4-mediated nociceptor hyperexcitability reverses painful diabetic neuropathy.
    J Clin Invest 2018 Mar 13. Epub 2018 Mar 13.
    Painful diabetic neuropathy (PDN) is an intractable complication of diabetes that affects 25% of patients. PDN is characterized by neuropathic pain and small-fiber degeneration, accompanied by dorsal root ganglion (DRG) nociceptor hyperexcitability and loss of their axons within the skin. The molecular mechanisms underlying DRG nociceptor hyperexcitability and small-fiber degeneration in PDN are unknown. Read More

    Diabetic neuropathy and the sensory neuron: new aspects of pathogenesis and their treatment implications.
    J Diabetes Investig 2018 Mar 13. Epub 2018 Mar 13.
    Division of Neurology and Department of Medicine, Neuroscience and Mental Health Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton.
    Diabetic polyneuropathy (DPN) continues to be generally considered as a "microvascular" complication of diabetes mellitus alongside nephropathy and retinopathy. The microvascular hypothesis, however, may be tempered by the concept that diabetes directly targets dorsal root ganglion sensory neurons. This neuron specific concept, supported by accumulating evidence, might account for important features of DPN, such as its early sensory neuron degeneration. Read More

    Atorvastatin prevents glomerular extracellular matrix formation by interfering with the PKC signaling pathway.
    Mol Med Rep 2018 Mar 9. Epub 2018 Mar 9.
    Department of Endocrinology, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541001, P.R. China.
    Platelet-activating factor (PAF) promotes glomerular extracellular matrix (ECM) deposition, primarily through activation of the protein kinase C (PKC) pathway. The present study was designed to investigate whether atorvastatin, which mediates a protective effect against glomerular ECM deposition and diabetic neuropathy, may interfere with the PKC‑transforming growth factor‑β1 (TGF‑β1) pathway in a model of human mesangial cells (HMCs) exposed to a high glucose (HG) and lysophosphatidylcholine (LPC) environment. HMCs were divided into three treatment groups: Control, high glucose and lysophosphatidylcholine (HG+LPC), and HG+LPC+atorvastatin. Read More

    Efficiencies of Low-Level Laser Therapy (LLLT) and Gabapentin in the Management of Peripheral Neuropathy: Diabetic Neuropathy.
    Appl Biochem Biotechnol 2018 Mar 12. Epub 2018 Mar 12.
    Complementary Medicine Department, National Research Centre, Dokki, Cairo, 12622, Egypt.
    Diabetic neuropathy (DN) is the highly occurred complication of diabetes mellitus; it has been defined as an event of peripheral nerve dysfunction characterized by pain, allodynia, hyperalgesia, and paraesthesia. The current study was conducted to evaluate the efficacy of low-level laser therapy (LLLT) in the management of neuropathy in diabetic rats. The used animals were divided into the following groups: negative control, streptozotocin-induced diabetic rats, and diabetic rats with peripheral neuropathy (DNP) and DNP treated with gabapentin or with LLLT. Read More

    Inhibition of protein tyrosine phosphatase 1B in spinal cord dorsal horn of rats attenuated diabetic neuropathic pain.
    Eur J Pharmacol 2018 Mar 8. Epub 2018 Mar 8.
    Department of Molecular Pharmacology, School of Pharmacy, Lanzhou University, Lanzhou, Gansu, P.R. China 730000. Electronic address:
    Protein tyrosine phosphatase 1B (PTP1B) has been shown to dephosphorylate and inactivate insulin receptors, which contributes to the pathogenesis of diabetes. Neuropathic pain is one of the severe complications that results from diabetic neuropathy. However, whether PTP1B was involved in the development of diabetic neuropathic pain is largely unknown. Read More

    Clinical correlates of sudomotor dysfunction in patients with type 2 diabetes and peripheral neuropathy.
    Diabetes Res Clin Pract 2018 Mar 7. Epub 2018 Mar 7.
    Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, India.
    Aims: To investigate the factors associated with abnormal electrochemical skin conductance (ESC) in patients with type 2 diabetes mellitus (T2D) and early diabetic peripheral neuropathy (DPN).

    Methods: We recruited 523 consecutive patients with T2D (median age: 50 [interquartile range: 16] years; median T2D duration: 4 [5] years). Sudomotor dysfunction was defined as an ESC <60 µS, and DPN as a neuropathy disability score (NDS) ≥6. Read More

    Complement C3 and Risk of Diabetic Microvascular Disease: A Cohort Study of 95202 Individuals from the General Population.
    Clin Chem 2018 Mar 9. Epub 2018 Mar 9.
    Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Herlev, Denmark.
    Background: Whether the complement system is involved in the development of diabetic microvascular disease is unknown. We tested the hypothesis that high concentrations of complement C3 are associated with increased risk of diabetic retinopathy, nephropathy, and neuropathy in individuals from the general population.

    Methods: We studied 95202 individuals from the general population with baseline measurements of complement C3, genotyped for rs1065489, rs429608, and rs448260 determining concentrations of complement C3, and enrolled in the Copenhagen General Population Study from 2003 through 2013, following them until April 10, 2013. Read More

    Effect of α-lipoic acid on symptoms and quality of life in patients with painful diabetic neuropathy.
    J Int Med Res 2018 Jan 1:300060518756540. Epub 2018 Jan 1.
    Diabetes Centre, First Department of Propaedeutic Internal Medicine, Medical School, 68993 National and Kapodistrian University of Athens , Laiko General Hospital, Athens, Greece.
    Objective To examine the effect of α-lipoic acid on neuropathic symptoms in patients with diabetic neuropathy (DN). Methods Patients with painful DN were treated with 600 mg/day α-lipoic acid, orally, for 40 days. Neuropathy Symptom Score (NSS), Subjective Peripheral Neuropathy Screen Questionnaire (SPNSQ) and douleur neuropathique (DN)4 questionnaire scores were assessed at baseline and day 40. Read More

    Fibre sub-type specific conduction reveals metabolic function in mouse sciatic nerve.
    J Physiol 2018 Mar 8. Epub 2018 Mar 8.
    School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK.
    The stimulus evoked compound action potential (CAP), recorded using suction electrodes, provides an index of the relative number of conducting axons within a nerve trunk. As such the CAP has been used to elucidate the diverse mechanisms of injury resulting from a variety of metabolic insults to central nervous white matter, whilst also providing a model with which to assess the benefits of clinically relevant neuro-protective strategies. In addition the technique lends itself to the study of metabolic cell-to-cell signalling that occurs between glial cells and neurones, and to exploring the ability of non-glucose substrates to support axon conduction. Read More

    Lumbar sympathectomy can improve symptoms associated with ischaemia, vasculitis, diabetic neuropathy and hyperhidrosis affecting the lower extremities-a single-centre experience.
    Ir J Med Sci 2018 Mar 7. Epub 2018 Mar 7.
    Department of Vascular Surgery, Mercy University Hospital, Cork, Ireland.
    Background: Lumbar sympthectomy (LS) was traditionally performed for intermittent claudication but is now eclipsed by revascularisation for that indication. However, it retains a role in the management of critical limb ischaemia and other conditions causing lower limb pain with or without ischaemia. We report the role of LS in modern surgical practice when revascularisation and pain management options have been exhausted. Read More

    Glycemic variability in continuous glucose monitoring is inversely associated with baroreflex sensitivity in type 2 diabetes: a preliminary report.
    Cardiovasc Diabetol 2018 Mar 7;17(1):36. Epub 2018 Mar 7.
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
    Background: It is presently unclear whether glycemic variability (GV) is associated with baroreflex sensitivity (BRS), which is an early indicator of cardiovascular autonomic neuropathy. The present study is the first to examine the relationships between BRS and GV measured using continuous glucose monitoring (CGM).

    Methods: This was a multicenter, prospective, open-label clinical trial. Read More

    Autonomic involvement in hereditary transthyretin amyloidosis (hATTR amyloidosis).
    Clin Auton Res 2018 Mar 6. Epub 2018 Mar 6.
    Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México.
    Purpose: Hereditary transthyretin amyloidosis (hATTR amyloidosis) is a progressive disease primarily characterized by adult-onset sensory, motor, and autonomic neuropathy. In this article, we discuss the pathophysiology and principal findings of autonomic neuropathy in hATTR amyloidosis, the most common methods of assessment and progression, and its relation as a predictive risk factor or a measure of progression in the natural history of the disease.

    Methods: A literature search was performed using the terms "autonomic neuropathy," "dysautonomia," and "autonomic symptoms" in patients with hereditary transthyretin amyloidosis and familial amyloid polyneuropathy. Read More

    An Overview on Diabetic foot Infections, including Issues Related to Associated Pain, Hyperglycemia and Limb Ischemia.
    Curr Pharm Des 2018 Mar 2. Epub 2018 Mar 2.
    Service of Infectious Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Switzerland.
    Factors strongly related to the risk of developing diabetic foot infections include vascular, neuropathic and hyperglycemic complications of long-standing diabetes mellitus. These infections are common and serious, posing a worldwide burden on administrative providers of healthcare, patients and physicians. The most appropriate approach to these infections is with a multidisciplinary team. Read More

    Efficacy of a Deep Learning System for Detecting Glaucomatous Optic Neuropathy Based on Color Fundus Photographs.
    Ophthalmology 2018 Mar 2. Epub 2018 Mar 2.
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China; Centre for Eye Research Australia; Departments of Ophthalmology and Surgery, University of Melbourne, Melbourne, Australia. Electronic address:
    Purpose: To assess the performance of a deep learning algorithm for detecting referable glaucomatous optic neuropathy (GON) based on color fundus photographs.

    Design: A deep learning system for the classification of GON was developed for automated classification of GON on color fundus photographs.

    Participants: We retrospectively included 48 116 fundus photographs for the development and validation of a deep learning algorithm. Read More

    Single Sensor Gait Analysis to Detect Diabetic Peripheral Neuropathy: A Proof of Principle Study.
    Diabetes Metab J 2018 Feb;42(1):82-86
    Movement Science Group, Oxford Brookes University, Oxford, UK.
    This study explored the potential utility of gait analysis using a single sensor unit (inertial measurement unit [IMU]) as a simple tool to detect peripheral neuropathy in people with diabetes. Seventeen people (14 men) aged 63±9 years (mean±SD) with diabetic peripheral neuropathy performed a 10-m walk test instrumented with an IMU on the lower back. Compared to a reference healthy control data set (matched by gender, age, and body mass index) both spatiotemporal and gait control variables were different between groups, with walking speed, step time, and SDa (gait control parameter) demonstrating good discriminatory power (receiver operating characteristic area under the curve >0. Read More

    Correlation of retinal neurodegeneration with measures of peripheral autonomic neuropathy in type 1 diabetes.
    Acta Ophthalmol 2018 Mar 5. Epub 2018 Mar 5.
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
    Purpose: To evaluate the relationship of neuroretinal layer thickness with sensitive measures of cardiovascular autonomic neuropathy in diabetic patients with non-proliferative diabetic retinopathy (NPDR).

    Methods: Twenty-seven eyes of 27 patients with type 1 diabetes presenting with mild-to-moderate NPDR were compared to 27 healthy control (HC) eyes matched for age and gender. The total macular volume (TMV) and the volumes of individual neurosensory layers in the macula were analysed from spectral domain optical coherence tomography using automated layer segmentation. Read More

    [Enzymological Studies on the Mechanisms of Pathogenesis of Diabetic Complications].
    Yakugaku Zasshi 2018 ;138(3):405-415
    Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts.
     Aldose reductase (AR) is involved in the pathogenesis of complications in diabetes. In this study, the enzymatic properties of AR isolated from various sources and a recombinant human AR (rh-AR) were analyzed in detail. The sensitivity of different forms of AR to several AR inhibitors (ARIs) was compared. Read More

    Cardiac autonomic function in children with type 1 diabetes.
    Eur J Pediatr 2018 Mar 2. Epub 2018 Mar 2.
    Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
    Cardiovascular autonomic neuropathy (CAN) is a major complication of type 1 diabetes (T1D). This study aimed to evaluate cardiac autonomic nervous system (ANS) function in children with T1D and its relation to different demographic, clinical and laboratory variable. This cross-sectional study included 60 children with T1D (mean age = 15. Read More

    [Diabetic dyslipidemia and microvascular complications of diabetes].
    Vnitr Lek 2018 ;64(1):17-24
    Diabetic dyslipidemia is one of the main risk factors for atherosclerosis. Although its participation in diabetic microvascular complications is not that dominant, dyslipidemia may play an important role in formation and progression of these complications. Pathophysiological mechanisms by which diabetic dyslipidemia affects the etiopathogenesis of diabetic nephropathy, retinopathy, neuropathy and diabetic foot are presented. Read More

    [Research advances on astragaloside-IV in treatment of diabetes mellitus and its complications pharmacological effects].
    Zhongguo Zhong Yao Za Zhi 2017 Dec;42(24):4700-4706
    Anhui University of Chinese Medicine, Hefei 230038, China.
    Diabetes has become a global public health problem that seriously threatens human health. Traditional Chinese medicine, the characteristics of the role of multiple targets, has a unique advantage in the prevention and treatment of diabetes mellitus and its complications. Astragaloside-Ⅳ (AS-Ⅳ), one of the main activities of Astragalus membranaceus, has a series of pharmacological effects including improvement in the function of endothelial cells and neovascularization, anti-inflammatory, antioxidant, regulating energy metabolism, protectionnervous, anti-cancer and so on. Read More

    Ameliorative effects of taurine against diabetes: a review.
    Amino Acids 2018 Feb 28. Epub 2018 Feb 28.
    Department of Food Science and Technology, College of Environmental and Agricultural Sciences, Islamia University Bahawalpur, Bhawalpur, Pakistan.
    Diets in rats and humans have shown promising results. Taurine improved glucagon activity, promoted glycemic stability, modified glucose levels, successfully addressed hyperglycemia via advanced glycation end-product control, improved insulin secretion and had a beneficial effect on insulin resistance. Taurine treatment performed well against oxidative stress in brain, increased the secretion of required hormones and protected against neuropathy, retinopathy and nephropathy in diabetes compared with the control. Read More

    Concentration of 8-isoprostanes in the exhaled breath condensate as a marker of oxidative stress in patients with type 1 diabetes.
    Adv Respir Med 2018 ;86(1):3-6
    Department of General and Oncological Pneumonology, First Chair of Internal Diseases, Medical University of Lodz, Kopcińskiego 22, 90-153 Łódź, Poland.
    Introduction: Type 1 diabetes is an insulin deficiency-based chronic disease. It leads to the development of hyperglycaemia, which plays a key role in the initiation and progression of tissue damage in patients with diabetes. This mostly results from oxidative stress, whose increased severity is observed in this group of patients. Read More

    Pinprick hypo- and hyperalgesia in diabetic rats: Can diet content affect experimental outcome?
    Neurosci Lett 2018 Feb 25;673:24-27. Epub 2018 Feb 25.
    Department of Anesthesiology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, 72205, USA. Electronic address:
    Existing literature concerning the effect of experimentally-induced diabetes on pain thresholds in rodent models remains controversial. In this work, we describe a phenotypical switch from streptozotocin-induced pinprick hypoalgesia to hyperalgesia observed in the same laboratory, in the same strain of rats, obtained from the same vendor, and measured by the same technique carried out by the investigators. This switch was observed around January 2015, at the time when there was a change in the diet of rats at the Radley North Carolina Charles River facility. Read More

    [Safety of fluoroquinolones: risks usually forgotten for the clinician].
    Rev Chilena Infectol 2017 Dec;34(6):577-582
    Sociedad Chilena de Infectología, Chile.
    Quinolones are a group of widely used antimicrobials. Although they are considered safe for patients, knowledge of the safety profile is necessary so that professionals become aware of what is necessary to monitor. At the musculoskeletal level, quinolones have the potential to damage cartilage, causing even tendon rupture in infrequent cases. Read More

    Risk Factors for Incident Diabetic Polyneuropathy in a Cohort With Screen-Detected Type 2 Diabetes Followed for 13 Years: ADDITION-Denmark.
    Diabetes Care 2018 Feb 27. Epub 2018 Feb 27.
    Research Unit for General Practice & Section for General Medical Practice Department of Public Health, Aarhus University, Aarhus, Denmark.
    Objective: To study incident diabetic polyneuropathy (DPN) prospectively during the first 13 years after a screening-based diagnosis of type 2 diabetes and determine the associated risk factors for the development of DPN.

    Research Design And Methods: We assessed DPN longitudinally in the Danish arm of the Anglo-Danish-Dutch study of Intensive Treatment of Diabetes in Primary Care (ADDITION) using the Michigan Neuropathy Screening Instrument questionnaire (MNSIQ), defining DPN with scores ≥4. Risk factors present at the diabetes diagnosis associated with the risk of incident DPN were estimated using Cox proportional hazard models adjusted for trial randomization group, sex, and age. Read More

    Gabapentin for Chronic Neuropathic Pain.
    JAMA 2018 02;319(8):818-819
    Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England.
    Clinical Question: Is gabapentin associated with pain relief in people with chronic neuropathic pain?

    Bottom Line: Oral gabapentin (1200-3600 mg/d for 4-12 weeks) for patients with moderate or severe neuropathic pain from postherpetic neuralgia (PHN) or painful diabetic neuropathy (PDN) is associated with pain reduction of at least 50% in 14% to 17% more patients than placebo. Read More

    Direct-to-Consumer Broadcast Advertisements for Pharmaceuticals: Off-Label Promotion and Adherence to FDA Guidelines.
    J Gen Intern Med 2018 Feb 26. Epub 2018 Feb 26.
    Collaboration for Research Integrity and Transparency (CRIT) at Yale University, New Haven, CT, USA.
    Background: Direct-to-consumer (DTC) advertisements for prescription drugs in the United States are regulated by the Food and Drug Administration (FDA). Off-label promotion, or the advertisement of a drug for an indication not approved by the FDA, is prohibited. Our objective was to examine the presence of off-label promotion in broadcast DTC ads and to assess their adherence to FDA guidelines mandating fair balance in presentation of risks and benefits and prohibiting misleading advertisement claims. Read More

    GLP‑1R agonists ameliorate peripheral nerve dysfunction and inflammation via p38 MAPK/NF‑κB signaling pathways in streptozotocin‑induced diabetic rats.
    Int J Mol Med 2018 May 23;41(5):2977-2985. Epub 2018 Feb 23.
    Department of Endocrinology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China.
    The present study aimed to investigate the mechanism of glucagon‑like peptide‑1 receptor (GLP‑1R) agonists in the progression of diabetic peripheral neuropathy (DPN) in streptozotocin (STZ)‑induced diabetic rats, through inflammatory signaling pathways. The DPN rat model was generated by intraperitoneal injection of STZ and then treated with the GLP‑1R agonist liraglutide or saline for 8 weeks. These animals were randomly divided into 4 groups (10 rats in each): The normal control + saline group, the normal control + liraglutide group, the diabetic + saline (DM) group and the diabetic + liraglutide (DML) group. Read More

    Cutaneous manifestations of diabetic peripheral neuropathy.
    Dermatoendocrinol 2017 6;9(1):e1395537. Epub 2017 Dec 6.
    Department of Dermatology, Venereology and Leprosy, Department of Endocrinology, Diabetes and Metabolism, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, Tamilnadu, India.
    There is a rise in number of people diagnosed with Diabetes Mellitus. The incidence is rising in modern Indian society because of Industrial development and drastically changing lifestyles. Diabetic neuropathies are microvascular disorders that are usually associated with the duration of Diabetes. Read More

    Denervation pseudohypertrophy of calf muscles associated with diabetic neuropathy.
    Radiol Case Rep 2017 Dec 25;12(4):815-820. Epub 2017 Jul 25.
    Department of Radiology, North District Hospital, Sheung Shui, Hong Kong.
    Denervation of muscle usually leads to muscle atrophy with fatty replacement but, uncommonly, also results in muscle hypertrophy or pseudohypertrophy with fatty replacement. We report the ultrasonographic and magnetic resonance imaging (MRI) findings of a patient with diffuse fatty infiltration of calf muscles as a result of denervation pseudohypertrophy. The elevated fasting glucose, neurogenic electromyographic changes, and muscle atrophy with adipose tissue infiltration are consistent with diabetic neuropathy as the cause of denervation pseudohypertrophy. Read More

    The prevalence and risk factors of peripheral neuropathy among patients with type 2 diabetes mellitus; the case of Jordan.
    Diabetol Metab Syndr 2018 21;10. Epub 2018 Feb 21.
    1National Center (Institute) for Diabetes, Endocrinology and Genetics (NCDEG), The University of Jordan, P.O Box 13165, Amman, 11942 Jordan.
    Background: Peripheral neuropathy is one of the most common microvascular complication of diabetes mellitus. This study is conducted to determine the prevalence of diabetic peripheral neuropathy (DPN) and its associated factors among patients with type 2 diabetes mellitus in Jordan.

    Methods: A cross-sectional study was conducted at the National Center for Diabetes, Endocrinology and Genetics, Jordan. Read More

    Microangiopathy-A Potential Contributing Factor to Idiopathic Polyneuropathy: A Mini Review.
    Front Neurol 2018 12;9:43. Epub 2018 Feb 12.
    Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden.
    Chronic idiopathic axonal polyneuropathy (CIAP) is a slowly progressive predominantly sensory axonal polyneuropathy. The prevalence of CIAP increases with age. The pathogenic cause of CIAP is unknown although there are several prevailing etiological hypotheses. Read More

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