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    Lower serum extracellular superoxide dismutase levels are associated with polyneuropathy in recent-onset diabetes.
    Exp Mol Med 2017 Nov 17;49(11):e394. Epub 2017 Nov 17.
    Institute for Clinical Diabetology, German Diabetes Center at Heinrich Heine University, Leibniz Center for Diabetes Research, Düsseldorf, Germany.
    Increased oxidative stress is implicated in the pathogenesis of experimental diabetic neuropathy, but translational evidence in recent-onset diabetes is scarce. We aimed to determine whether markers of systemic oxidative stress are associated with diabetic sensorimotor polyneuropathy (DSPN) in recent-onset diabetes. In this cross-sectional study, we measured serum concentrations of extracellular superoxide dismutase (SOD3), thiobarbituric acid reactive substances (TBARS), and reduced glutathione (GSH) in 107 type 1 and 215 type 2 diabetes patients from the German Diabetes Study baseline cohort and 37 glucose-tolerant individuals (controls). Read More

    Ptosis as the only manifestation of diabetic superior division oculomotor nerve palsy: A case report.
    Medicine (Baltimore) 2017 Nov;96(46):e8739
    aDepartment of Neurology, Kaohsiung Medical University Hospital, Kaohsiung Medical University bDepartment of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung cPhD Program in Translational Medicine, Kaohsiung Medical University and Academia Sinica dDepartment of Neurology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
    Rationale: Diabetic oculomotor nerve palsies, also called ischemic third nerve palsies, are the most common etiologic subset of oculomotor nerve palsy in adults. Diabetic oculomotor nerve palsies typically present with ptosis and diplopia, but pupillary function is often spared. The oculomotor nerve separates into superior division and inferior division, with the superior division innervating the superior rectus and levator palpebrae superioris. Read More

    The Inhibitory Effects of Cobalt Protoporphyrin IX and Cannabinoid 2 Receptor Agonists in Type 2 Diabetic Mice.
    Int J Mol Sci 2017 Oct 28;18(11). Epub 2017 Oct 28.
    Grup de Neurofarmacologia Molecular, Institut d'Investigació Biomèdica Sant Pau, 08025 Barcelona, Spain.
    The activation of the transcription factor Nrf2 inhibits neuropathy and modulates the activity of delta-opioid receptors (DOR) in type 2 diabetic mice but the impact of Nrf2/HO-1 pathway on the antinociceptive actions of cannabinoid 2 receptors (CB2R) has not been assessed. Using male mice BKS.Cg-m+/+Leprdb/J (db/db) we investigated if treatment with cobalt protoporphyrin IX (CoPP), an HO-1 inductor, inhibited mechanical allodynia, hyperglycemia and obesity associated to type 2 diabetes. Read More

    The Feasibility of Intraperitoneal Placenta-Derived Mesenchymal Stem Cell Injection in Stomachs of Diabetic Mice.
    J Gastroenterol Hepatol 2017 Nov 15. Epub 2017 Nov 15.
    Division of Gastroenterology, Department of Medicine, CHA University School of Medicine, CHA Bundang Medical Center, Department of Pathology, CHA University School of Medicine, CHA Bundang Medical Center, Seongnam, Gyeonggi, Korea.
    Background/aims: Diabetic gastropathy is associated with loss of Interstitial cells of Cajal (ICCs) and autonomic neuropathy. Effective management for diabetic gastropathy is still unavailable. This study was aimed to confirm the pathogenetic changes in diabetic gastropathy and to examine the effect of treatment with placental derived mesenchymal stem cells (PDMSCs) in stomachs of animal models. Read More

    Diabetic and sympathetic influences on the water permeability barrier function of human skin as measured using transepidermal water loss: A case-control study.
    Medicine (Baltimore) 2017 Nov;96(45):e8611
    aDepartment of Physical Medicine and Rehabilitation, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul bDepartment of Rehabilitation Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Hanyang, Gyeonggi-do, Republic of Korea.
    The presence of long-standing hyperglycemic conditions has been suggested to lead to many skin problems associated with an impaired skin barrier function. However, the relationship between impaired skin barrier status and altered peripheral nervous system function has not yet been determined. The purpose of this study was to investigate the water evaporation rate as a measure of the permeability barrier function of diabetic skin and its relationship to diabetic sensorimotor polyneuropathy (DSPN) and peripheral autonomic neuropathy (PAN) using well-controlled confounding variables. Read More

    Combination of Ewing test, heart rate variability, and heart rate turbulence analysis for early diagnosis of diabetic cardiac autonomic neuropathy.
    Medicine (Baltimore) 2017 Nov;96(45):e8296
    aDepartment of Endocrinology bDepartment of Neurology, The First Affiliated Hospital of Shantou University Medical College cShantou University Medical College, Shantou, China.
    The aim of this study was to compare and analyze Ewing test, heart rate variability (HRV), and heart rate turbulence (HRT) in the diagnosis of cardiac autonomic neuropathy (CAN) in diabetic patients.Ninety diabetic patients (age 18-78) and 20 nondiabetic control subjects were studied. Standard Ewing test and 24-hour Holter was performed in all participants to evaluate CAN. Read More

    The relationship between neutrophil-to-lymphocyte ratio and diabetic peripheral neuropathy in Type 2 diabetes mellitus.
    Medicine (Baltimore) 2017 Nov;96(45):e8289
    aZhujiang Hospital, Southern Medical University bState Key Laboratory of Respiratory Disease, National Clinical Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
    To explore the relationship between neutrophil-to-lymphocyte ratio (NLR) and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus.A total of 557 newly diagnosed Type 2 Diabetes Mellitus (T2DM) patients were recruited, including 397 T2DM patients without complication (DM group) as well as 160 T2DM patients complicated with DPN (DPN group). Student t test, Mann-Whitney U test, or χ test was applied to the data of the 2 groups, including the levels of neutrophils and lymphocytes as well as the NLR values of peripheral blood and other biochemistry indexes; Pearson correlation analysis was used to calculate the correlation of NLR and detected factors; risk factors of DPN were estimated via logistic regression analysis and multivariate analysis. Read More

    Hypoglycaemic episodes and risk of diabetic peripheral neuropathy in patients with type 2 diabetes.
    Diabetes Metab 2017 Nov 8. Epub 2017 Nov 8.
    Neurological Institute, Taichung Veterans General Hospital, No. 1650, Taiwan Boulevard, Sec. 4, 40705 Taichung City, Taiwan; Department of Neurology, School of Medicine, National Yang-Ming University, No. 155, Sec. 2, Linong Street, 112 Taipei City, Taiwan. Electronic address:

    Analysis of a Screening System for Diabetic Cardiovascular Autonomic Neuropathy in China.
    Med Sci Monit 2017 Nov 10;23:5354-5362. Epub 2017 Nov 10.
    Department of Integrative Medicine, Huashan Hospital of Fudan University, Shanghai, China (mainland).
    BACKGROUND The aim of this study was to create a screening system for diabetic cardiovascular autonomic neuropathy (DCAN) in diabetic patients. MATERIAL AND METHODS A Chinese cohort of 455 diabetic participants was recruited between 2011 and 2013. Short-term heart rate variability testing was used to evaluate cardiovascular autonomic function. Read More

    Lipoic Acid Combined with Epalrestat versus Lipoic Acid in Treating Diabetic Peripheral Neuropathy:A Meta-analysis.
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2017 10;39(5):656-664
    The First School of Clinic Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510405,China.
    Objective To compare the clinical effectiveness of lipoic acid combined with epalrestat versus lipoic acid in treating diabetic peripheral neuropathy(DPN). Methods Randomized controlled trials(RCTs) and clinical controlled trials on lipoic acid versus epalrestat for DPN before February 2016 were searched through five databases:CNKI,CBM,VIP,Wanfang,and PubMed. The quality of the included trials were assessed using Cochrane software and Jadad scores. Read More

    Vitamin D and Type 2 Diabetes Mellitus.
    Adv Exp Med Biol 2017 ;996:193-205
    Endocrinology Consultant, Ain Wazein Medical Village, Lebanon- Mount of Lebanon-Shouf Area, Lebanon, PA, Lebanon.
    Type 2 diabetes mellitus (T2DM) has become a significant global health care problem and its reported incidence is increasing at an alarming rate. Despite the improvement in therapy and development of new drugs, treatment still remains insufficient especially due to the associated side effects of most available drugs. Efforts are continuing toward disease prevention and search for safer drugs. Read More

    A novel curcumin derivative for the treatment of diabetic neuropathy.
    Neuropharmacology 2017 Nov 6. Epub 2017 Nov 6.
    The Salk Institute for Biological Studies, La Jolla, CA, USA.
    Neuropathy is a common complication of long-term diabetes. Proposed mechanisms of neuronal damage caused by diabetes that are downstream of hyperglycemia and/or loss of insulin signaling include ischemic hypoxia, inflammation and loss of neurotrophic support. The curcumin derivative J147 is a potent neurogenic and neuroprotective drug candidate initially developed for the treatment of neurodegenerative conditions associated with aging that impacts many pathways implicated in the pathogenesis of diabetic neuropathy. Read More

    Muscle force distribution of the lower limbs during walking in diabetic individuals with and without polyneuropathy.
    J Neuroeng Rehabil 2017 Nov 9;14(1):111. Epub 2017 Nov 9.
    Physical Therapy, Speech and Occupational Therapy department, School of Medicine, University of Sao Paulo, Sao Paulo, SP, Brazil.
    Background: Muscle force estimation could advance the comprehension of the neuromuscular strategies that diabetic patients adopt to preserve walking ability, which guarantees their independence as they deal with their neural and muscular impairments due to diabetes and neuropathy. In this study, the lower limb's muscle force distribution during gait was estimated and compared in diabetic patients with and without polyneuropathy.

    Methods: Thirty individuals were evaluated in a cross-sectional study, equally divided among controls (CG) and diabetic patients with (DNG) and without (DG) polyneuropathy. Read More

    Berberine Ameliorates Diabetic Neuropathy: TRPV1 Modulation by PKC Pathway.
    Am J Chin Med 2017 Nov 9:1-15. Epub 2017 Nov 9.
    1 Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, Jiangsu, P. R. China.
    In recent years, berberine has increasingly become a topic of research as a treatment for diabetes due to its repair function, which recovers damaged pancreatic β cells. However, it is the complications of diabetes that seriously affect patients' life quality and longevity, among which diabetic neuropathy and the consequent acute pain are the most common. In this study, we established STZ-induced diabetic models to observe whether berberine, a main constitute of Coptis chinensis Franch which has shown good hypoglycemic effects, could relieve diabetes-induced pain and explored its possible mechanism in rats and mice. Read More

    Computer aided diagnosis of diabetic foot using infrared thermography: A review.
    Comput Biol Med 2017 Oct 26;91:326-336. Epub 2017 Oct 26.
    Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, Singapore; Department of Biomedical Engineering, School of Science and Technology, SIM University, Singapore; Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Malaysia.
    Diabetes mellitus (DM) is a chronic metabolic disorder that requires regular medical care to prevent severe complications. The elevated blood glucose level affects the eyes, blood vessels, nerves, heart, and kidneys after the onset. The affected blood vessels (usually due to atherosclerosis) may lead to insufficient blood circulation particularly in the lower extremities and nerve damage (neuropathy), which can result in serious foot complications. Read More

    Impaired peripheral nerve regeneration in type-2 diabetic mouse model.
    Eur J Neurosci 2017 Nov 9. Epub 2017 Nov 9.
    Department of Medical Chemistry, Kansai Medical University.
    Peripheral neuropathy is one of the most common and serious complications of type-2 diabetes. Diabetic neuropathy is characterized by a distal symmetrical sensorimotor polyneuropathy, and its incidence increases in patients 40 years of age or older. In spite of extensive research over decades, there are few effective treatments for diabetic neuropathy besides glucose control and improved lifestyle. Read More

    Diagnostic Accuracy of Monofilament Tests for Detecting Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis.
    J Diabetes Res 2017 8;2017:8787261. Epub 2017 Oct 8.
    Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Objective: To systematically evaluate the diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy.

    Methods: We searched EMBASE (OvidSP), MEDLINE (OvidSP), the Cochrane Library, and Web of Science to identify diagnostic accuracy trials of monofilament tests for detecting diabetic peripheral neuropathy. We used a hierarchical summary receiver operating characteristics (HSROC) model to conduct the meta-analysis of diagnostic accuracy of monofilament tests for detecting diabetic peripheral neuropathy. Read More

    Hierarchical models for epidermal nerve fiber data.
    Stat Med 2017 Nov 7. Epub 2017 Nov 7.
    Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden.
    While epidermal nerve fiber (ENF) data have been used to study the effects of small fiber neuropathies through the density and the spatial patterns of the ENFs, little research has been focused on the effects on the individual nerve fibers. Studying the individual nerve fibers might give a better understanding of the effects of the neuropathy on the growth process of the individual ENFs. In this study, data from 32 healthy volunteers and 20 diabetic subjects, obtained from suction induced skin blister biopsies, are analyzed by comparing statistics for the nerve fibers as a whole and for the segments that a nerve fiber is composed of. Read More

    Cardiac autonomic neuropathy in type 2 diabetes mellitus using Bellavere's score system.
    Int J Health Sci (Qassim) 2017 Nov-Dec;11(5):26-29
    Department of Medicine, Unaizah College of Medicine, Qassim University, Unaizah, Saudi Arabia.
    Objective: Determine the frequency of cardiac autonomic neuropathy (CAN) in type 2 diabetics using Bellavere's score system.

    Subjects And Methods: The present cross-sectional study was conducted at the Department of Medicine, Isra University Hospital Hyderabad from March to November 2011. Sixty voluntary participants of type 2 diabetes mellitus (DM) were selected through non-probability purposive sampling. Read More

    The impact of diabetes on corneal nerve morphology and ocular surface integrity.
    Ocul Surf 2017 Nov 4. Epub 2017 Nov 4.
    School of Optometry & Vision Science, University of New South Wales, Sydney, Australia.
    Diabetes mellitus is a chronic disease that results from inadequate insulin production or ineffective insulin utilization. It is one of the most common systemic diseases worldwide with increasing prevalence. Diabetes mellitus is associated with premature mortality, macrovascular complications such as cardiovascular disease, and microvascular complications, including nephropathy leading to kidney failure, potentially blinding diabetic retinopathy, and diabetic neuropathy. Read More

    Differential associations of lower cardiac vagal tone with insulin resistance and insulin secretion in recently diagnosed type 1 and type 2 diabetes.
    Metabolism 2017 Nov 4. Epub 2017 Nov 4.
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany; German Center for Diabetes Research (DZD), München-Neuherberg, Germany; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
    Objective: It is unclear to which extent altered insulin sensitivity/secretion contribute to the development of diabetic cardiovascular autonomic neuropathy (CAN) characterized by diminished heart rate variability (HRV). We hypothesised that lower HRV is differentially associated with measures of insulin resistance and insulin secretion in recent-onset type 1 and type 2 diabetes.

    Materials/methods: This cross-sectional study included participants from the German Diabetes Study with type 1 (n=275) or type 2 diabetes (n=450) with known diabetes duration ≤1 year and glucose-tolerant controls (n=81). Read More

    Severity of Neuropathy Is Associated With Long-Term Spinal Cord Stimulation Outcome in Painful Diabetic Peripheral Neuropathy: Five-Year Follow-up of a Prospective Two-Center Clinical Trial.
    Diabetes Care 2017 Nov 6. Epub 2017 Nov 6.
    Department of Anesthesiology and Pain Medicine, Maastricht University Medical Center, Maastricht, the Netherlands
    Objective: Evidence from prospective studies for long-term treatment efficacy of spinal cord stimulation (SCS) in painful diabetic polyneuropathy (PDPN) is not available. We report prospective data on the effect of SCS on pain ratings, treatment success and failure, and complications during a 5-year follow-up in patients with PDPN.

    Research Design And Methods: Patients with PDPN (n = 48) were included in this prospective multicenter study. Read More

    Association between a MIR499A polymorphism and diabetic neuropathy in type 2 diabetes.
    J Diabetes Complications 2017 Oct 26. Epub 2017 Oct 26.
    Department of Systems Medicine, Endocrinology, University of Rome "Tor Vergata", Italy.
    Aims: Diabetic polyneuropathy (DPN) and cardiovascular autonomic neuropathy (CAN) affect a large percentage of diabetic people and impact severely on quality of life. As it seems that miRNAs and their variations might play a role in these complications, we investigated whether the rs3746444 SNP in the MIR499A gene could be associated with susceptibility to DPN and/or CAN.

    Methods: We analyzed 150 participants with type 2 diabetes. Read More

    Association between diabetes mellitus and olfactory dysfunction: current perspectives and future directions.
    Diabet Med 2017 Nov 6. Epub 2017 Nov 6.
    Clinical Research Core NY, USA.
    The increasing global prevalence of diabetes mellitus presents a significant challenge to healthcare systems today. Although diabetic retinopathy, nephropathy and neuropathy are well-established complications of diabetes, there is a paucity of research examining the impact of dysglycaemia on the olfactory system. Olfaction is an important sense, playing a role in the safety, nutrition and quality of life of an individual, but its importance is often overlooked when compared with the other senses. Read More

    Diseases of the retina and the optic nerve associated with obstructive sleep apnea.
    Sleep Med Rev 2017 May 29. Epub 2017 May 29.
    Grenoble Alpes University, HP2 Laboratory, INSERM U1042, Grenoble, France; Department of Ophthalmology, University Hospital of Grenoble, Grenoble, France. Electronic address:
    Many associations between ocular disorders and obstructive sleep apnea (OSA) have been studied, such as nonarteritic anterior ischemic optic neuropathy, glaucoma, papilledema, retinal vein occlusion, eyelid hyperlaxity, lower-eyelid ectropion and recurrent corneal erosions. The objective of this review is to synthetize the possible vascular disorders of the retina and the optic nerve associated with sleep apnea patients and to discuss the underlying pathophysiological hypotheses. Main mechanisms involved in the ocular complications of OSA are related to intermittent hypoxia, sympathetic system activation, oxidant stress, and deleterious effects of endothelin 1. Read More

    Angiotensin receptor blocker use and gastro-oesophageal cancer survival: a population-based cohort study.
    Aliment Pharmacol Ther 2017 Nov 3. Epub 2017 Nov 3.
    Centre for Public Health, Queen's University Belfast, Belfast, UK.
    Background: Angiotensin receptor blockers (ARBs; including candesartan, losartan, olmesartan and valsartan) are widely used to treat hypertension, heart failure and diabetic neuropathy. There is considerable pre-clinical evidence that ARBs can reduce cancer progression, particularly for gastric cancer. Despite this, epidemiological studies have yet to assess the impact of ARB use on gastro-oesophageal cancer survival. Read More

    Clinical fractures among older men with diabetes are mediated by diabetic complications.
    J Clin Endocrinol Metab 2017 Nov 1. Epub 2017 Nov 1.
    Duke University, Durham Veterans Affairs Medical Center.
    Introduction: Type 2 diabetes mellitus among older women has been associated with increased bone mineral density, but paradoxically increased fracture risk. Findings among older men have varied, and potential mechanisms have not been fully elucidated.

    Methods: Retrospective study of male Veterans 65-99 years of age who received primary care in the Veterans Health Administration (VHA) from 2000 to 2010, using administrative data from all 146 VHA medical centers linked to Centers for Medicare and Medicaid Services (CMS) Medicare fee-for-service data. Read More

    Three-question set from Michigan Neuropathy Screening Instrument adds independent prognostic information on cardiovascular outcomes: analysis of ALTITUDE trial.
    Diabetologia 2017 Nov 3. Epub 2017 Nov 3.
    Institute of Cardiovascular Science, University College London, London, UK.
    Aims/hypothesis: The self-administered Michigan Neuropathy Screening Instrument (MNSI) is used to diagnose diabetic peripheral neuropathy. We examined whether the MNSI might also provide information on risk of death and cardiovascular outcomes.

    Methods: In this post hoc analysis of the Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE) trial, we divided 8463 participants with type 2 diabetes and chronic kidney disease (CKD) and/or cardiovascular disease (CVD) into independent training (n = 3252) and validation (n = 5211) sets. Read More

    Autologous Bone Marrow-Derived Stem Cells for Treating Diabetic Neuropathy in Metabolic Syndrome.
    Biomed Res Int 2017 1;2017:8945310. Epub 2017 Oct 1.
    Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
    Diabetic neuropathy is one of the most common and serious complications of diabetes mellitus and metabolic syndrome. The current therapy strategies, including glucose control and pain management, are not effective for most patients. Growing evidence suggests that infiltration of inflammation factors and deficiency of local neurotrophic and angiogenic factors contribute significantly to the pathologies of diabetic neuropathy. Read More

    Interactions of Notch1 and TLR4 signaling pathways in DRG neurons of in vivo and in vitro models of diabetic neuropathy.
    Sci Rep 2017 Nov 2;7(1):14923. Epub 2017 Nov 2.
    Department of Rheumatology, Shandong University Qilu Hospital, Jinan, 250012, China.
    Understanding the interactions between Notch1 and toll-like receptor 4 (TLR4) signaling pathways in the development of diabetic peripheral neuropathy may lead to interpretation of the mechanisms and novel approaches for preventing diabetic neuropathic pain. In the present study, the interactions between Notch1 and TLR4 signaling pathways were investigated by using dorsal root ganglion (DRG) from diabetic neuropathic pain rats and cultured DRG neurons under high glucose challenge. The results showed that high glucose induced not only Notch1 mRNA, HES1 mRNA, and TLR4 mRNA expression, but also Notch1 intracellular domain (NICD1) and TLR4 protein expression in DRG neurons. Read More

    Ophthalmic and clinical factors that predict four-year development and worsening of diabetic retinopathy in type 1 diabetes.
    J Diabetes Complications 2017 Sep 14. Epub 2017 Sep 14.
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia.
    Aims: To investigate the role of ophthalmic imaging markers - namely retinal thickness measures and corneal nerve morphology - in predicting four-year development and worsening of diabetic retinopathy (DR) in type 1 diabetes (T1DM).

    Methods: 126 eyes of 126 participants with T1DM were examined at baseline and after four years. Diabetic retinopathy (DR) was graded using the Early Treatment Diabetic Retinopathy Study scale. Read More

    Severity and multiplicity of microvascular complications are associated with QT interval prolongation in patients with type 2 diabetes.
    J Diabetes Investig 2017 Nov 2. Epub 2017 Nov 2.
    Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
    Aims/introduction: A prolonged QT interval plays a causal role in life-threatening arrhythmia and becomes a risk factor for sudden cardiac death. Here, we assessed the association between microvascular complications and the QT interval in patients with type 2 diabetes.

    Materials And Methods: Patients with type 2 diabetes (n = 219) admitted to our hospital for glycemic control were enrolled. Read More

    Ameliorative potential of rutin in combination with nimesulide in STZ model of diabetic neuropathy: targeting Nrf2/HO-1/NF-kB and COX signalling pathway.
    Inflammopharmacology 2017 Nov 1. Epub 2017 Nov 1.
    Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India.
    Emerging role of Nrf-2/HO-1 in pathogenesis of diabetic neuropathy has been suggested. Diabetic neuropathy is one of the most common complications of diabetes and more than 50% patients of diabetes develop diabetic neuropathy. Rutin has been well documented to show protective effect in various complications, e. Read More

    Exenatide upregulates gene expression of glucagon like peptide-1 receptor and nerve growth factor in streptozotocin/nicotinamide-induced diabetic mice.
    Fundam Clin Pharmacol 2017 Nov 1. Epub 2017 Nov 1.
    Department of Medical Pharmacology, Psychopharmacology Lab., Medical Faculty, Kocaeli University, Kocaeli, Turkey.
    Glucagon like peptide-1 (GLP-1) is an incretine hormon that has modulating effects on insulin release. GLP-1 and receptors for GLP-1 are widely expressed throughout the body including brain.The expression of GLP-1 receptors is very specific to large neurons in hippocampus, neocortex and cerebellum. Read More

    Role of "Sural Sparing" Pattern (Absent/Abnormal Median and Ulnar with Present Sural SNAP) Compared to Absent/Abnormal Median or Ulnar with Normal Sural SNAP in Acute Inflammatory Demyelinating Polyneuropathy.
    Front Neurol 2017 29;8:512. Epub 2017 Sep 29.
    Department of Neurology, University of Missouri, Columbia, MO, United States.
    Background: Sural sparing defined as absent/abnormal median sensory nerve action potential (SNAP) amplitude or absent/abnormal ulnar SNAP amplitude with a normal sural SNAP amplitude is thought to be a marker for inflammatory demyelinating polyneuropathies.

    Objective: If sural sparing pattern specifically defined as absent/abnormal median and ulnar SNAP amplitude with normal sural SNAP amplitude (AMUNS) is sensitive and specific when compared with either absent/abnormal median and normal sural (AMNS) or absent/abnormal ulnar and normal sural (AUNS) for acute inflammatory demyelinating polyneuropathy (AIDP), chronic inflammatory demyelinating polyneuropathy (CIDP), select non-diabetic axonopathies (AXPs), and diabetic neuropathies (DNs).

    Method: Retrospective analysis from 2001 to 2010 on all newly diagnosed AIDP, CIDP, select non-diabetic AXP, and DN. Read More

    Diabetes-Related Induction of the Heme Oxygenase System and Enhanced Colocalization of Heme Oxygenase 1 and 2 with Neuronal Nitric Oxide Synthase in Myenteric Neurons of Different Intestinal Segments.
    Oxid Med Cell Longev 2017 10;2017:1890512. Epub 2017 Sep 10.
    Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged H-6726, Hungary.
    Increase in hyperglycaemia-induced oxidative stress and decreased effectiveness of endogenous defense mechanisms plays an essential role in the initiation of diabetes-related neuropathy. We demonstrated that nitrergic myenteric neurons display different susceptibilities to diabetic damage in different gut segments. Therefore, we aim to reveal the gut segment-specific differences in the expression of heme oxygenase (HO) isoforms and the colocalization of these antioxidants with neuronal nitric oxide synthase (nNOS) in myenteric neurons. Read More

    Absent monofilament sensation in a type 2 diabetic feet.
    London J Prim Care (Abingdon) 2017 Sep 4;9(5):73-76. Epub 2017 Sep 4.
    Department of Acute Medicine & Endocrinology, Watford General Hospital, Watford, UK.
    Neuropathy is a common complication which can affect up to 90% of patients with diabetes mellitus. Asymptomatic neuropathy is a common presentation. We present a case that emphasises the importance of foot screening in people with diabetes. Read More

    Clinical and economic burdens experienced by patients with painful diabetic peripheral neuropathy: An observational study using a Japanese claims database.
    PLoS One 2017 27;12(10):e0187250. Epub 2017 Oct 27.
    Pfizer Japan, Tokyo, Japan.
    Background: Diabetic peripheral neuropathy (DPN) may often be painful. Despite the high prevalence of painful DPN (pDPN) among patients with diabetes mellitus (DM), understanding of its clinical and economic burden is limited. This study aimed to describe the clinical and economic burdens faced by patients with pDPN in Japan, and compared them with those experienced by patients with DPN but without painful symptoms (non-pDPN). Read More

    Comparison of topical capsaicin and topical turpentine Oil for treatment of painful diabetic neuropathy.
    J Ayub Med Coll Abbottabad 2017 Jul-Sep;29(3):384-387
    Faisalabad Institute of Cardiology, Faisalabad, Pakistan.
    Background: Diabetes Mellitus is a pandemic of the modern era owing to our rapidly deteriorating lifestyle. Painful diabetic neuropathy is one of the costliest and disabling complications of diabetes mellitus. No single treatment exists to prevent or reverse neuropathic changes or to provide total pain relief. Read More

    Andrographolide reorganise hyperglycaemia and distorted antioxidant profile in streptozotocin-induced diabetic rats.
    Cardiovasc Hematol Agents Med Chem 2017 Oct 26. Epub 2017 Oct 26.
    Animal Physiology & Biochemistry laboratory, Department of Zoology, Osmania University, Hyderabad-500007. India.
    Diabetes mellitus (DM) is a constant and illimitable metabolic disorder that can happen even at a young age due to the virtual absence of naturally acting insulin, which uptakes and accumulates glucose; thereby reduce the use of glucose. In the present study, we evaluated the neuroprotective efficacy of andrographolide on streptozotocin (STZ) induced diabetic Sprague dawley rats. Diabetes was induced by intraperitonial injection of STZ (45 mg/kg B. Read More

    The feasibility of using high-resolution ultrasonography to assess ulnar nerve in patients with diabetes mellitus.
    J Ultrason 2017 Sep 29;17(70):160-166. Epub 2017 Sep 29.
    University of Wyoming College of Health Sciences; Wyoming INBRE Program, Laramie, WY, USA.
    Objective: The aim of this study was to investigate the usefulness of high-resolution ultrasonography for the diagnosis of polyneuropathy in diabetes mellitus patients by the examination of the ulnar nerves.

    Method: We recruited 100 healthy age-matched volunteers (50 women and 50 men) with 200 arms without diabetes or cubital tunnel syndrome as the control group. We assessed the upper limbs of 100 diabetes mellitus patients (45 women and 55 men), 40 of whom had electrophysiologically confirmed diabetic peripheral neuropathy and 60 had no diabetic peripheral neuropathy in the upper limbs. Read More

    Optimization of surgical outcome in lower extremity nerve decompression surgery.
    Plast Reconstr Surg 2017 Oct 13. Epub 2017 Oct 13.
    1Department of Plastic-, Reconstructive- and Hand surgery, Erasmus University Medical Center, Rotterdam, the Netherlands. 2 Department of Plastic-, Reconstructive- and Hand surgery, Franciscus Gasthuis, Rotterdam, the Netherlands. 2 Department of Plastic-, Reconstructive- and Hand surgery, Utrecht University Medical Center, Utrecht, the Netherlands 4 Department of Plastic-, Reconstructive- and Hand surgery, Ziekenhuis Rivierenland, Tiel, the Netherlands.
    Background: There is still debate whether the surgical release of entrapped lower extremity nerves reduces complaints of associated neuropathy and results in gain of sensory function. The aim of this study is to investigate which factors are associated with a favorable surgical outcome, by follow-up of patients previously participating in a randomized controlled trial.

    Methods: We evaluated the 5-years follow-up of diabetic patients previously participating in the Lower Extremity Nerve entrapment Study (LENS). Read More

    Development of a youth-report measure of DPN symptoms: Conceptualization and content validation.
    J Clin Transl Endocrinol 2017 Sep 8;9:55-60. Epub 2017 Jul 8.
    Temple University College of Public Health, United States.
    Aims: To develop a content valid youth-report measure of diabetic peripheral neuropathy (DPN) symptoms.

    Methods: Semi-structured interviews with 5 clinicians and 15 youth aged 8-17 with diabetes were conducted to elicit and clarify youth's DPN experiences. A systematic review of existing adult-report DPN symptom measures was conducted to identify item concepts representative of each experience. Read More

    The association between vitamin D level and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus: An update systematic review and meta-analysis.
    J Clin Transl Endocrinol 2017 Sep 3;9:25-31. Epub 2017 Jun 3.
    Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China.
    Aim: Recently, increasing studies have been carried out to explore the association between vitamin D level and the development of diabetic peripheral neuropathy (DPN) in patients with diabetes mellitus (DM). However, because of the shortcoming in study design and sample size, there is still no clear conclusion. We performed this meta-analysis to examine the exact impact of vitamin D deficiency on DPN in type 2 diabetic patients. Read More

    Temporal trend of autonomic nerve function and HSP27, MIF and PAI-1 in type 1 diabetes.
    J Clin Transl Endocrinol 2017 Jun 20;8:15-21. Epub 2017 Mar 20.
    Department of Translational Medicine - Hand Surgery, Lund University, Skåne University Hospital, Jan Waldenströms gata 5, 205 02 Malmö, Sweden.
    Aim: Diabetes mellitus type 1 (T1D) has numerous complications including autonomic neuropathy, i.e. dysfunction of the autonomous nervous system. Read More

    Treatment-Induced Neuropathy of Diabetes.
    Curr Diab Rep 2017 Oct 24;17(12):127. Epub 2017 Oct 24.
    Beth Israel Deaconess Medical Center, 185 Pilgrim Rd, Palmer 111, Boston, MA, 02215, USA.
    Purpose Of Review: Treatment-induced neuropathy of diabetes (TIND) is an under-recognized iatrogenic painful sensory and autonomic neuropathy. This review highlights the clinical symptoms and signs, raises awareness of the cause, and provides education about prevention of TIND.

    Recent Findings: TIND may be triggered by a rapid decline in the blood glucose levels following the use of insulin, oral hypoglycemic medications, or even diet only to control diabetes. Read More

    Cardiorespiratory Fitness and Cardiac Autonomic Function in Diabetes.
    Curr Diab Rep 2017 Oct 23;17(12):125. Epub 2017 Oct 23.
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany.
    Purpose Of Review: This review summarizes the current knowledge on the relationship of physical activity, exercise, and cardiorespiratory fitness (CRF) with cardiovascular autonomic neuropathy (CAN) based on epidemiological, clinical, and interventional studies.

    Recent Findings: The prevalence of CAN increases with age and duration of diabetes. Further risk factors for CAN comprise poor glycemic control, dyslipidemia, abdominal obesity, hypertension, and the presence of diabetic complications. Read More

    Prevalence, severity and factors associated with peripheral neuropathy among newly diagnosed diabetic patients attending Mulago hospital: a cross-sectional study.
    Afr Health Sci 2017 Jun;17(2):463-473
    Department of Medicine, Mulago Hospital, P.O. Box 5052 Kampala, Uganda.
    Aims: To determine the prevalence and associated risk factors of diabetic peripheral neuropathy (DPN) among newly diagnosed diabetes mellitus patients in Mulago Hospital.

    Methods: A cross-sectional study was conducted among 248 newly diagnosed adult diabetic patients. Using the standard Neuropathy Symptom Score (NSS) and Neuropathy Disability Score (NDS) criteria, we screened them for neuropathy. Read More

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