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    1 OF 529

    Peripheral Glial Cells in the Development of Diabetic Neuropathy.
    Front Neurol 2018 2;9:268. Epub 2018 May 2.
    Department of Biomedicine, Nordic-EMBL Partnership for Molecular Medicine, Danish Research Institute of Translational Neuroscience (DANDRITE), Aarhus University, Aarhus, Denmark.
    The global prevalence of diabetes is rapidly increasing, affecting more than half a billion individuals within the next few years. As diabetes negatively affects several physiological systems, this dramatic increase represents not only impaired quality of life on the individual level but also a huge socioeconomic challenge. One of the physiological consequences affecting up to half of diabetic patients is the progressive deterioration of the peripheral nervous system, resulting in spontaneous pain and eventually loss of sensory function, motor weakness, and organ dysfunctions. Read More

    Feasibility and effectiveness of electrochemical dermal conductance measurement for the screening of diabetic neuropathy in primary care. DECODING Study (Dermal Electrochemical Conductance in Diabetic Neuropathy). Rationale and design.
    Medicine (Baltimore) 2018 May;97(20):e10750
    Jordi Gol Primary Care Research Institute, Catalan Health Institute, Primary Health Care Division, Reus-Barcelona, Catalonia.
    Diabetes mellitus is the leading cause of polyneuropathy in the Western world. Diabetic neuropathy is a frequent complication of diabetes and may have great clinical transcendence due to pain and possible ulceration of the lower extremities. It is also a relevant cause of morbidity and mortality in patients with diabetes. Read More

    Pinch aperture proprioception: reliability and feasibility study.
    J Phys Ther Sci 2018 May 8;30(5):734-740. Epub 2018 May 8.
    Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center: Mail stop 2002, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
    [Purpose] To establish the reliability and feasibility of a novel pinch aperture device to measure proprioceptive joint position sense. [Subjects and Methods] Reliability of the pinch aperture device was assessed in 21 healthy subjects. Following familiarization with a 15° target position of the index finger and thumb, subjects performed 5 trials in which they attempted to actively reproduce the target position without visual feedback. Read More

    Neuroprotective effect of duloxetine in a mouse model of diabetic neuropathy: Role of glia suppressing mechanisms.
    Life Sci 2018 May 12. Epub 2018 May 12.
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt. Electronic address:
    Aims: Painful diabetic neuropathy (PDN) is one of the most frequent complications of diabetes and the current therapies have limited efficacy. This study aimed to study the neuroprotective effect of duloxetine, a serotonin noradrenaline reuptake inhibitor (SNRI), in a mouse model of diabetic neuropathy.

    Main Methods: Nine weeks after developing of PDN, mice were treated with either saline or duloxetine (15 or 30 mg/kg) for four weeks. Read More

    Association between serum magnesium and common complications of diabetes mellitus.
    Technol Health Care 2018 Apr 27. Epub 2018 Apr 27.
    Background: Magnesium ion, as important cation in the human body, involved in various enzymatic reactions, glucose transport and insulin release. Now diabetes mellitus and diabetic complications have become important public health problems around the world.

    Objective: This paper explores the association between concentration levels of serum magnesium and common complications and comorbidities of diabetes mellitus and other biochemical indexes. Read More

    Neuroprotective and antinociceptive effects of rosemary (Rosmarinus officinalis L.) extract in rats with painful diabetic neuropathy.
    J Physiol Sci 2018 May 12. Epub 2018 May 12.
    Physiology-Pharmacology Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
    Diabetes mellitus is associated with the development of neuronal tissue damage in different central and peripheral nervous system regions. A common complication of diabetes is painful diabetic peripheral neuropathy. We have explored the antihyperalgesic and neuroprotective properties of Rosmarinus officinalis L. Read More

    Risk factors for diabetic foot ulcer recurrence: A prospective 2-year follow-up study in Egypt.
    Foot (Edinb) 2017 Dec 28;35:11-15. Epub 2017 Dec 28.
    Department of Internal Medicine, Endocrinology and Diabetes Unit, Assiut University, Assiut, Egypt. Electronic address:
    Objectives: To determine the frequency of diabetic foot ulcer recurrence and its potential risk factors.

    Methods: This study included 93 patients with type 2 diabetes and followed for 2 years after primary healed foot ulceration. Demographic, diabetes related, comorbid and ulcer related variables were investigated as risk factors. Read More

    Transcriptome analysis of dorsal root ganglia's diabetic neuropathy reveals mechanisms involved in pain and regeneration.
    Life Sci 2018 May 8. Epub 2018 May 8.
    Structural and Functional Biology Department, Biology Institute, University of Campinas, PO Box 6109, 13083-970 Campinas, Sao Paulo, Brazil. Electronic address:
    Peripheral diabetic neuropathy (DN) manifests in nearly 60% of diabetic patients, being pain its most debilitating symptom. Although electrophysiological and morphological aspects are well described, little is known about its development and progression, undermining effective therapies. Hyperglycemia and insulin signaling impairment are considered the triggering events of oxidative stress observed in the dying nerves, however there are still many gaps in the knowledge of intracellular plastic changes it generates. Read More

    Effect of combined dyslipidemia and hyperglycemia on diabetic peripheral neuropathy in alloxan-induced diabetic WBN/Kob rats.
    J Toxicol Pathol 2018 Apr 12;31(2):125-133. Epub 2018 Feb 12.
    Laboratory of Pathology, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotohge-cho, Hirakata, Osaka 573-0101, Japan.
    Clinical and experimental research have suggested that dyslipidemia aggravates diabetic peripheral neuropathy (DPN). However, whether dyslipidemia is a risk factor for DPN remains unclear. To investigate the effect of dyslipidemia on DPN, morphological features of peripheral nerves were analyzed in diabetic rats treated with a high-fat diet (HFD). Read More

    High-Resolution Nerve Ultrasound and Electrophysiological Findings in Restless Legs Syndrome.
    J Neuroimaging 2018 May 11. Epub 2018 May 11.
    Department of Neurology, St. Josef Hospital, Ruhr-University Bochum, Bochum, Germany.
    Background And Purpose: Restless legs syndrome (RLS) is a multifactorial network disorder of a sensorimotor system extending from dopaminergic and glutamatergic cerebral structures to the spinal neurons and peripheral nerves. The role of peripheral nerve damage in the causality and severity progression for RLS patients remains unclear.

    Methods: We performed a clinical and epidemiological study on a cohort of 34 RLS patients focusing on RLS risk factors and disease severity. Read More

    Photobiomodulation induces antinociception, recovers structural aspects and regulates mitochondrial homeostasis in peripheral nerve of diabetic mice.
    J Biophotonics 2018 May 11:e201800110. Epub 2018 May 11.
    Laboratory of Neuromodulation of Experimental Pain, Department of Anatomy, University of São Paulo, Brazil.
    Diabetic Peripheral Neuropathy (DPN) is a nervous disorder caused by diabetes mellitus, affecting about 50% of patients in clinical medicine. Chronic pain is one of the major and most unpleasant symptoms developed by those patients, and conventional available treatments for the neuropathy, including the associated pain, are still unsatisfactory and benefit only a small number of patients. Photobiomodulation (PBM) has been gaining clinical acceptance once it is able to promote early nerve regeneration resulting in significant improvement peripheral nerves disabilities. Read More

    Georgian Med News 2018 Apr(277):21-27
    I Propedeutical Internal Medicine Clinic of AHEPA University Hospital, Aristotle University of Thessaloniki, Greece.
    One of the main causes of amputations in patients with Diabetes Mellitus patients is a chronic diabetic foot ulcer. The authors present a clinical case and discussion of a successful use of Granulocyte-Macrophages Colony Stimulating Factor (GM-CSF) treatment for the promotion of healing of a chronic diabetic foot ulcer. A 65 year-old woman was admitted to the Diabetes Center with complaints of a deep non-healing chronic foot ulcer for the last 18 months. Read More

    BSMI single nucleotide polymorphism in vitamin D receptor gene is associated with decreased circulatory levels of serum 25-hydroxyvitamin D among micro and macrovascular complications of type 2 diabetes mellitus.
    Int J Biol Macromol 2018 May 5;116:346-353. Epub 2018 May 5.
    Department of Biochemistry and Molecular Genetics, Prof. M. Viswanathan Diabetes Research Centre and M.V. Hospital for Diabetes (A WHO Collaborating Centre for Research, Education & Training in Diabetes), International Diabetes Federation, Centre of Education and Centre of Excellence in Diabetes Care, Royapuram, Chennai 600 013, Tamilnadu, India. Electronic address:
    Vitamin D Receptor (VDR) gene single nucleotide polymorphism (SNP) in the intron 8 is a well characterized SNP which has previously been linked to various diseases including Type 2 Diabetes Mellitus (T2DM). However, the association of this SNP with micro and macrovascular complications of T2DM remains poorly studied. Hence, the present study was designed to investigate the association of VDR gene SNP with complications of T2DM (disease phenotype) and correlated it with the serum levels of (25[OH]D) (intermediate phenotype) along with other clinical risk factors of T2DM. Read More

    Standard analgesics reverse burrowing deficits in a rat CCI model of neuropathic pain, but not in models of type 1 and type 2 diabetes-induced neuropathic pain.
    Behav Brain Res 2018 May 5. Epub 2018 May 5.
    Boehringer Ingelheim Pharma GmbH & Co. KG, Div. Research Germany, Birkendorfer Str. 65, Biberach an der Riss, Germany. Electronic address:
    Background: Burrowing is a rodent behavior validated as a robust and reproducible outcome measure to infer the global effect of pain in several inflammatory pain models. However, less is known about the effect of analgesics on burrowing in neuropathic pain models and no studies have determined burrowing performance in models of diabetes-associated neuropathic pain.

    Objective: To compare the sensitivity of the burrowing assay in different neuropathic pain models: mononeuropathic pain and diabetic polyneuropathy. Read More

    Perception of diabetic foot ulcers among general practitioners in four European countries: knowledge, skills and urgency.
    J Wound Care 2018 05;27(5):310-319
    Familie Ziekenhuis, Department of Endocrinology, Chimay, Belgium.
    Objective: Diabetic foot ulcers (DFU) have the potential to deteriorate rapidly, in the absence of prompt assessment and treatment. The aim of this study was to analyse the awareness and perception of DFU among general practitioners (GPs) from four European countries, and to find possible differences between these countries in terms of management.

    Method: A two-part, quantitative, online questionnaire was distributed to GPs across four countries in Europe-the UK, France, Germany and Spain. Read More

    Association of vitamin D deficiency with diabetic peripheral neuropathy and diabetic nephropathy in Tianjin, China.
    Asia Pac J Clin Nutr 2018 ;27(3):599-606
    Department of Endocrinology, Tianjin Union Medical Center, Tianjin, China. 13207628978
    Background And Objectives: To evaluate the association of vitamin D deficiency with type 2 diabetic peripheral neuropathy (DPN) and diabetic nephropathy (DN).

    Methods And Study Design: A total of 287 type 2 diabetic patients were categorized in two ways, and each divided into two groups: DPN (n=164) and non-DPN (NDPN) groups (n=123); and DN (n=148) and non-DN (NDN) groups (n=139). Enzyme-linked immunosorbent assay was used to measure the 25-hydroxy vitamin D [25(OH)D3] level. Read More

    Comparison of peripheral nerve protection between insulin-based glucose control and alpha lipoic acid (ALA) in the streptozotocin (STZ)-induced diabetic rat.
    Endocrine 2018 May 7. Epub 2018 May 7.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, South Korea.
    Strict glucose control is a well-proven therapeutic approach for peripheral neuropathies in patients with diabetes. Alpha lipoic acid (ALA) has also been accepted as a therapeutic agent for diabetic peripheral neuropathy (DPN) in the respect of pathogenesis. However, the potential of ALA as a treatment for DPN in comparison to that of glucose control is unclear. Read More

    Susceptible and Prognostic Genetic Factors Associated with Diabetic Peripheral Neuropathy: A Comprehensive Literature Review.
    Int J Endocrinol 2018 15;2018:8641942. Epub 2018 Mar 15.
    Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
    Type 2 diabetes mellitus (T2D) is a disorder of glucose metabolism. It is a complex process involving the regulation of insulin secretion, insulin sensitivity, gluconeogenesis, and glucose uptake at the cellular level. Diabetic peripheral neuropathy (DPN) is one of the debilitating complications that is present in approximately 50% of diabetic patients. Read More

    Incidence and Risk Factors of Diabetic Foot Ulcer: A Population-Based Diabetic Foot Cohort (ADFC Study)-Two-Year Follow-Up Study.
    Int J Endocrinol 2018 15;2018:7631659. Epub 2018 Mar 15.
    Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
    Aim/introduction: This study was carried out to assess the incidence and risk factors of diabetic foot ulcer (DFU).

    Materials And Methods: In this prospective cohort study in a university hospital, all the participants were examined and followed up for new DFU as final outcome for two years. To analyze the data, the variables were first evaluated with a univariate analysis. Read More

    Acupuncture Combined with Hydrotherapy in Diabetes Patients with Mild Lower-Extremity Arterial Disease: A Prospective, Randomized, Nonblinded Clinical Study.
    Med Sci Monit 2018 May 8;24:2887-2900. Epub 2018 May 8.
    Department of General Surgery, First Hospital of Qinhuangdao, Qinhuangdao, Hebei, China (mainland).
    BACKGROUND The aim of this pragmatic study was to explore the intervention of acupuncture combined with hydrotherapy and perceived effects in type 2 diabetic patients with recently diagnosed, mild, lower-extremity arterial disease (LEAD) in comparison with a control group. MATERIAL AND METHODS One hundred twenty-six diabetes patients who were diagnosed mild LEAD according to ankle-brachial blood pressure index (ABPI) and peripheral neuropathy symptom were randomly assigned to either an experimental (n=64) or control group (n=62). The experimental group attended and completed (1) a 30-min session of acupuncture in certain selected points, and (2) a 30-min hydrotherapy exercise every 2 days for 15 weeks. Read More

    The correlation between obstructive sleep apnea and diabetic neuropathy: A meta-analysis.
    Prim Care Diabetes 2018 May 1. Epub 2018 May 1.
    Department of Respiratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China. Electronic address:
    Background: The aim of this study was to explore the correlation between obstructive sleep apnea (OSA) and diabetic neuropathy.

    Materials And Methods: After working out searching strategy, literatures were screened from the electronic databases: PubMed, Embase, and the Cochrane library. R 3. Read More

    Diabetic foot syndrome (DFS) in patients with diabetes. A multicenter German/Austrian DPV analysis on 33,870 DFS patients among 358,986 adult subjects with diabetes.
    Diabetes Metab Res Rev 2018 May 3:e3020. Epub 2018 May 3.
    Institute of Epidemiology and Medical Biometry, ZIBMT, University of Ulm, Ulm, Germany.
    Aims: The diabetic foot syndrome (DFS) is a serious complication in patients with diabetes increasing the risk for minor/major amputations. This analysis aimed to examine differences in diabetes patients with or without DFS stratified by type 1 (T1D) or type 2 diabetes (T2D).

    Material And Methods: Adult patients (≥20y of age) with diabetes from the German/Austrian DPV-registry were included. Read More

    A high ankle-brachial index is associated with obesity and low serum 25-hydroxyvitamin D in patients with diabetes.
    J Clin Transl Endocrinol 2018 Mar 3;11:7-10. Epub 2018 Feb 3.
    Department of Endocrinology and Metabolism, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia.
    Peripheral artery disease (PAD), when present with diabetes, is associated with significant morbidity and mortality. The spectrum of PAD in diabetes includes atherosclerosis with stenotic disease; and diffuse medial calcification with non-compliant arteries, as reflected by high ankle brachial index. The clinical characteristics of a high ABI are less well characterized than that of low ABI. Read More

    Salient features and outcomes of Charcot foot - An often-overlooked diabetic complication: A 17-year-experience at a diabetic center in Bangkok.
    J Clin Transl Endocrinol 2018 Mar 31;11:1-6. Epub 2018 Jan 31.
    Diabetes and Thyroid Center, Theptarin Hospital, 3858 Rama IV Rd, Klong Toey, Bangkok 10110, Thailand.
    Background: Charcot foot is a rare but a serious diabetic condition. Recognition of this often overlooked condition to provide timely and proper management is important for a better prognosis. Limited data on Charcot foot was available in Asians. Read More

    Cardiovascular Autonomic Neuropathy and Glucose Variability in Patients With Type 1 Diabetes: Is There an Association?
    Front Endocrinol (Lausanne) 2018 19;9:174. Epub 2018 Apr 19.
    First Department of Medicine, University of Szeged, Szeged, Hungary.
    Introduction: The oxidative stress associated with glucose variability might be responsible for neuronal damage while autonomic neuropathy (AN) has a detrimental effect on metabolism. The aim of the study was to find relationship between AN and GV in type 1 diabetic patients and to identify further factors that affect GV.

    Patients And Methods: Twenty type 1 diabetic patients were involved (age: 39. Read More

    Establishing Differences in Thermographic Patterns between the Various Complications in Diabetic Foot Disease.
    Int J Endocrinol 2018 12;2018:9808295. Epub 2018 Mar 12.
    Faculty of Health Sciences, University of Malta, Msida, Malta.
    Aim: To evaluate the potential of thermography as an assessment tool for the detection of foot complications by understanding the variations in temperature that occur in type 2 diabetes mellitus (DM).

    Methods: Participants were categorized according to a medical examination, ankle brachial index, doppler waveform analysis, and 10-gram monofilament testing into five groups: healthy adult, DM with no complications, DM with peripheral neuropathy, DM with neuroischaemia, and DM with peripheral arterial disease (PAD) groups. Thermographic imaging of the toes and forefeet was performed. Read More

    Expression of Nrf2 Promotes Schwann Cell-Mediated Sciatic Nerve Recovery in Diabetic Peripheral Neuropathy.
    Cell Physiol Biochem 2018 26;46(5):1879-1894. Epub 2018 Apr 26.
    Background/aims: High glucose-induced oxidative stress and inflammatory responses play an important role in painful diabetic neuropathy by activating the TLR4/NFκB signal pathway. Schwann cells (SCs) are integral to peripheral nerve biology, contributing to saltatory conduction along axons, nerve and axon development, and axonal regeneration. SCs provide a microenvironment favoring vascular regeneration but their low survival ratio in hyperglycemic conditions suppress the function to promote nerve growth. Read More

    Remote Temperature Monitoring in Diabetic Foot Ulcer Detection.
    Wounds 2018 Apr;30(4):E44-E48
    Introduction: Diabetic foot ulcers (DFUs) are associated with increased morbidity, mortality, and resource utilization. Remote temperature monitoring (RTM) is an evidence-based and recommended component of standard preventative foot care for high-risk populations that can detect the inflammation preceding and accompanying DFUs.

    Objective: This case series illustrates the use of a RTM foot mat for the early detection and prevention of DFUs in patients with a history of DFUs. Read More

    Phosphodiesterase 4 and 7 inhibitors produce protective effects against high glucose-induced neurotoxicity in PC12 cells via modulation of the oxidative stress, apoptosis and inflammation pathways.
    Metab Brain Dis 2018 Apr 30. Epub 2018 Apr 30.
    Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
    Diabetic neuropathy (DN) is the most common diabetic complication. It is estimated diabetic population will increase to 592 million by the year 2035. This is while at least 50-60% of all diabetic patients will suffer from neuropathy in their lifetime. Read More

    Follow up of MRI bone marrow edema in the treated diabetic Charcot foot - a review of patient charts.
    Diabet Foot Ankle 2018 26;9(1):1466611. Epub 2018 Apr 26.
    Department of Diagnostic and Interventional Radiology, HELIOS University Hospital Wuppertal, University Witten/Herdecke, Wuppertal, Germany.
    : Ill-defined areas of water-like signal on bone magnetic resonance imaging (MRI), characterized as bone marrow edema or edema-equivalent signal-changes (EESC), is a hallmark of active-stage pedal neuro-osteoarthropathy (Charcot foot) in painless diabetic neuropathy, and is accompanied by local soft-tissue edema and hyperthermia. The longitudinal effects on EESC of treating the foot in a walking cast were elucidated by reviewing consecutive cases of a diabetic foot clinic. : Retrospective observational study, chart review : Cases with active-stage Charcot foot were considered, in whom written reports on baseline and follow-up MRI studies were available for assessment. Read More

    Glycated hemoglobin targets and glycemic control: Link with lipid, uric acid and kidney profile.
    Diabetes Metab Syndr 2018 Apr 24. Epub 2018 Apr 24.
    Faculty of Medicine, Tarumanagara University, Jl. Letjen S. Parman No.1, Jakarta, Indonesia. Electronic address:
    Aims: To compare uric acid, lipid, and kidney profile along with management and complications of Indonesian diabetic patients with good and poor glycemic control based on glycated hemoglobin profile.

    Materials And Methods: Data was obtained from medical records of Internal Medicine Clinic in Hermina Podomoro General Hospital for the period January-December 2015. Subjects were grouped into good and poor glycemic control groups based on their glycated hemoglobin (HbA1c) levels. Read More

    Diabetic Peripheral Neuropathy: Epidemiology, Diagnosis, and Pharmacotherapy.
    Clin Ther 2018 Apr 27. Epub 2018 Apr 27.
    Diabetes and Endocrinology Research, Department of Eye and Vision Sciences and Pain Research Institute, Institute of Ageing and Chronic Disease, University of Liverpool and Aintree University Hospital NHS Foundation Trust, Liverpool, United Kingdom; Department of Diabetes and Endocrinology, Royal Liverpool and Broadgreen University NHS Hospital Trust, Liverpool, United Kingdom; Division of Endocrinology, Diabetes and Gastroenterology, University of Manchester, Manchester, United Kingdom. Electronic address:
    Purpose: Diabetic peripheral neuropathy (DPN) is the commonest cause of neuropathy worldwide, and its prevalence increases with the duration of diabetes. It affects approximately half of patients with diabetes. DPN is symmetric and predominantly sensory, starting distally and gradually spreading proximally in a glove-and-stocking distribution. Read More

    The Association between Serum Bilirubin Level and Electrochemical Skin Conductance in Chinese Patients with Type 2 Diabetes.
    Int J Endocrinol 2018 7;2018:6253170. Epub 2018 Mar 7.
    Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, China.
    Bilirubin is an antioxidant and plays a protective role against cardiovascular and microvascular disease. The aim of this study is to explore the possible protective effect of bilirubin on small nerve function. A total of 265 Chinese patients with type 2 diabetes mellitus (T2DM) were enrolled in the study. Read More

    Extracellular Matrix Remodeling and Modulation of Inflammation and Oxidative Stress by Sulforaphane in Experimental Diabetic Peripheral Neuropathy.
    Inflammation 2018 Apr 27. Epub 2018 Apr 27.
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
    The peripheral nervous system is one of many organ systems that can be profoundly impacted in diabetes mellitus. Diabetic peripheral neuropathy has a significant negative effect on patients' quality of life as it begins with loss of limbs' sensation and may result in lower limb amputation. This investigation aimed at exploring the effect of sulforaphane on peripheral neuropathy in diabetic rats. Read More

    [Warming acupuncture combined with conventional acupuncture for diabetic peripheral neuropathy with syndrome of deficiency and cold coagulation, obstruction of collaterals and blood stasis].
    Zhongguo Zhen Jiu 2018 Mar;38(3):229-32
    Heilongjiang University of TCM, Harbin 150040.
    Objective: To compare the clinical efficacy differences between warming acupuncture and conventional acupuncture for diabetic peripheral neuropathy (DPN) with syndrome of deficiency and cold coagulation, obstruction of collaterals and blood stasis.

    Methods: A total of 64 patients were randomly divided into a warming acupuncture group and a conventional acupuncture group, 32 cases in each one. Based on basic treatment of blood glucose regulation, warming acupuncture was applied at Pishu (BL 20), Shenshu (BL 23), Guanyuanshu (BL 26), Zusanli (ST 36), Chongyang (ST 42), Quchi (LI 11) and Hegu (LI 4) in the warming acupuncture group, while acupuncture was applied at the identical acupoints in the conventional acupuncture group. Read More

    Spermidine prevents high glucose-induced senescence in HT-22 cells by upregulation of CB1 receptor.
    Clin Exp Pharmacol Physiol 2018 Apr 26. Epub 2018 Apr 26.
    Institute of Neuroscience, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, 42100, Hunan, P R China.
    Hyperglycemia-induced neurotoxicity involves in the pathogenesis of diabetic encephalopathy and neuronal senescence is one of the worst effects of hyperglycemic neurotoxicity. Cannabinoid receptor type 1 (CB1) has neuroprotective function in a series of neuropathy. Spermidine (Spd) has anti-aging function in many tissues. Read More

    Peripheral Neuropathy in Children and Adolescents with Insulin-dependent Diabetes Mellitus.
    Iran J Child Neurol 2018 ;12(2):83-90
    Department of Pediatric Endocrinology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
    Objective: Type 1 diabetes mellitus (T1DM) is a chronic immune-mediated disease. Diabetic peripheral neuropathy (DPN) is an important microvascular complication of T1DM. One of the most important risk factors for the development of DPN is poor glycemic control. Read More

    Chronic Nerve Compression Accelerates the Progression of Diabetic Peripheral Neuropathy in a Rat Model: A Study of Gene Expression Profiling.
    J Reconstr Microsurg 2018 Apr 25. Epub 2018 Apr 25.
    Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai, China.
    Objective:  This article investigates the role of chronic nerve compression in the progression of diabetic peripheral neuropathy (DPN) by gene expression profiling.

    Methods:  Chronic nerve compression was created in streptozotocin (STZ)-induced diabetic rats by wrapping a silicone tube around the sciatic nerve (SCN). Neurological deficits were evaluated using pain threshold test, motor nerve conduction velocity (MNCV), and histopathologic examination. Read More

    Baseline High-Sensitivity C-Reactive Protein Predicts Macrovascular and Microvascular Complications of Type 2 Diabetes: A Population-Based Study.
    Ann Nutr Metab 2018 Apr 25;72(4):287-295. Epub 2018 Apr 25.
    Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
    Background/aims: This prospective study is aimed at examining the predictive value of high-sensitivity C-reactive protein (hs-CRP) for coronary heart disease (CHD) events and microvascular complications of type 2 diabetes mellitus (T2DM).

    Methods: A population-based study (NCT02958579) was conducted on 1,301 participants with T2DM (mean follow-up of 7.5 years). Read More

    Inhibition of C298S mutant of human aldose reductase for antidiabetic applications: Evidence from in silico elementary mode analysis of biological network model.
    J Cell Biochem 2018 Apr 25. Epub 2018 Apr 25.
    Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi Arabia.
    Human aldose reductase (hAR) is the key enzyme in sorbitol pathway of glucose utilization and is implicated in the etiology of secondary complications of diabetes, such as, cardiovascular complications, neuropathy, nephropathy, retinopathy, and cataract genesis. It reduces glucose to sorbitol in the presence of NADPH and the major cause of diabetes complications could be the change in the osmotic pressure due to the accumulation of sorbitol. An activated form of hAR (activated hAR or ahAR) poses a potential obstacle in the development of diabetes drugs as hAR-inhibitors are ineffective against ahAR. Read More

    Predictors of Cardiovascular Autonomic Neuropathy Onset and Progression in a Cohort of Type 1 Diabetic Patients.
    J Diabetes Res 2018 5;2018:5601351. Epub 2018 Mar 5.
    Institut des Maladies Métaboliques et Cardiovasculaires, INSERM, Université de Toulouse, 1 avenue Jean Poulhès, BP 84225, 31432 Toulouse Cedex 4, France.
    Aim: The prevalence of cardiovascular autonomic neuropathy (CAN) in diabetes mellitus is well documented. However, the rate and predictors of both the development and progression of CAN have been less studied. Hereby, we assessed the rate and the major risk factors for CAN initiation and progression in a cohort of type 1 diabetic patients followed over a three-year period. Read More

    Expression of Macrophage Migration Inhibitory Factor in Footpad Skin Lesions with Diabetic Neuropathy.
    Mol Pain 2018 Jan 1:1744806918775482. Epub 2018 Jan 1.
    Kangbuk Samsung Medical Center.
    Background Diabetic neuropathy (DN) originating in distal lower extremities is associated with pain early in the disease course, overwhelming in the feet. However, the pathogenesis of DN remains unclear. Macrophage migration inhibitory factor (MIF) has been implicated in the onset of neuropathic pain and the development of diabetes. Read More

    Swimming Exercise Induced Reversed Expression of miR-96 and Its Target Gene NaV1.3 in Diabetic Peripheral Neuropathy in Rats.
    Chin J Physiol 2018 04;61(2):124-129
    Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
    Diabetes is a common metabolic disease which leads to diabetic peripheral neuropathy. Recently, the role of microRNA-96 (miR-96) in alleviating neuropathic pain by inhibiting the expression of NaV1.3, an isoform of voltage-gated sodium channels, has been shown. Read More

    Clinical spectrum and quality of life in patients with chronic polyneuropathy: A cross-sectional study.
    J Peripher Nerv Syst 2018 Apr 23. Epub 2018 Apr 23.
    Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
    Chronic polyneuropathy is a disabling condition of the peripheral nerves, characterized by symmetrical sensory motor symptoms and signs. There is paucity of studies on the etiological spectrum of polyneuropathy and its impact on quality of life (QoL). The present cross-sectional study in a referral based tertiary care center in North India found diabetic neuropathy as the commonest cause (25. Read More

    Fluoxetine pretreatment enhances neurogenic, angiogenic and immunomodulatory effects of MSCs on experimentally induced diabetic neuropathy.
    Cell Tissue Res 2018 Apr 23. Epub 2018 Apr 23.
    Department of Medical Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
    Being one of the most debilitating complications among diabetic patients, diabetic polyneuropathy (DPN) is a paramount point of continuous research. Stem cell therapies have shown promising results. However, limited cell survival and paracrine activities hinder its transfer from bench to bedside. Read More

    The Effectiveness of Aerobic Exercise in Improving Peripheral Nerve Functions in Type 2 Diabetes Mellitus: An Evidence Based Case Report.
    Acta Med Indones 2018 Jan;50(1):82-87
    Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
    Background: peripheral neuropathy is known as one of most common complication in diabetes mellitus type 2 patient. This complication is caused by uncontrolled condition of blood glucose level in long periode. Regular physical activity in moderate to high intensity is beneficial in management of diabetes mellitus. Read More

    Saliva versus Plasma Therapeutic Drug Monitoring of Pregabalin in Jordanian Patients.
    Drug Res (Stuttg) 2018 Apr 23. Epub 2018 Apr 23.
    Triumpahrma LLC, Amman, Jordan.
    The objective is using saliva instead of plasma for pregabalin therapeutic drug monitoring (TDM) since saliva reflects the free non-protein bound drug concentration, simple and noninvasive sampling, cheaper and does not require the expertise of drawing blood. Forty four patients participated in this study, two samples of saliva and another two of blood were taken from each patient; first sample of both saliva and blood is the trough sample and was taken just before the first dose of the day and second sample is the peak sample and was taken 1 h after taking the first dose of the day. Descriptive statistics and t-testing after log transformation were done using Excel, p-value=0. Read More

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