31,078 results match your criteria Diabetic Neuropathy


Diabetes coexistent with Charcot-Marie-Tooth disease presenting as a recurrent foot ulcer misdiagnosed as diabetic foot: a case report.

J Diabetes Investig 2021 May 15. Epub 2021 May 15.

Innovation Center for Wound Repair, Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, P. R. China.

Both diabetes mellitus (DM) and Charcot-Marie-Tooth disease (CMT) can lead to severe peripheral neuropathy. The differential diagnosis of peripheral neuropathy is difficult due to the similar clinical features. There are still some clues, such as unusual muscle atrophy, unmatched severity of peripheral neurogenic damage with nephropathy or retinopathy, which could alert clinicians to make differential diagnosis. Read More

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Malfunctioning CD106-positive, short-term hematopoietic stem cells trigger diabetic neuropathy in mice by cell fusion.

Commun Biol 2021 May 14;4(1):575. Epub 2021 May 14.

Department of Stem Cell Biology and Regenerative Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.

Diabetic neuropathy is an incurable disease. We previously identified a mechanism by which aberrant bone marrow-derived cells (BMDCs) pathologically expressing proinsulin/TNF-α fuse with residential neurons to impair neuronal function. Here, we show that CD106-positive cells represent a significant fraction of short-term hematopoietic stem cells (ST-HSCs) that contribute to the development of diabetic neuropathy in mice. Read More

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Microvascular Disease and Cardiovascular Outcomes in Type 2 Diabetes: The Look AHEAD Study.

Diabetes Res Clin Pract 2021 May 11:108859. Epub 2021 May 11.

Department of Medicine, Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins School of Medicine, Baltimore, MD, USA; Welch Prevention Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA. Electronic address:

Aim: To evaluate the associations of microvascular disease (MVD) with incident cardiovascular disease (CVD) in individuals with type 2 diabetes.

Methods: A total of 4098 participants with type 2 diabetes and without CVD were assessed for MVD (diabetic kidney disease, retinopathy or neuropathy) in the Look AHEAD (Action for Health in Diabetes) study. Cox models were used to generate hazard ratios (HRs) for: (1) CVD composite (myocardial infarction, stroke, hospitalization for angina and/or death from cardiovascular causes), (2) coronary artery disease (CAD), (3) stroke, and (4) CVD-related deaths. Read More

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Diabetic neuropathy: A narrative review of risk factors, classification, screening and current pathogenic treatment options (Review).

Exp Ther Med 2021 Jul 29;22(1):690. Epub 2021 Apr 29.

Department of Diabetes, Nutrition and Metabolic Diseases, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Diabetic neuropathy (DN) is a frequent complication of diabetes mellitus (DM) with severe consequences as it progresses and influences all human body systems. This review discusses the risk factors for DN, the main characteristics of the clinical forms of DN, the screening methods and the current therapeutic options. Distal symmetric DN is the primary clinical form, and DM patients should be screened for this complication. Read More

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miRNA targets in painful diabetic neuropathy.

Authors:
Ian Fyfe

Nat Rev Neurol 2021 May 13. Epub 2021 May 13.

Nature Reviews Neurology, .

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Prevalence and incidence of diabetic peripheral neuropathy in Latin America and the Caribbean: A systematic review and meta-analysis.

PLoS One 2021 13;16(5):e0251642. Epub 2021 May 13.

Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Perú.

Aims: The objective of this systematic review and meta-analysis is to estimate the prevalence and incidence of diabetic peripheral neuropathy (DPN) in Latin America and the Caribbean (LAC).

Materials And Methods: We searched MEDLINE, SCOPUS, Web of Science, EMBASE and LILACS databases of published observational studies in LAC up to December 2020. Meta-analyses of proportions were performed using random-effects models using Stata Program 15. Read More

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From the low-density lipoprotein receptor-related protein 1 to neuropathic pain: a potentially novel target.

Pain Rep 2021 9;6(1):e898. Epub 2021 Mar 9.

Department of Neurology, University Hospital of Würzburg, Würzburg, Germany.

This review describes the roles of the low-density lipoprotein receptor-related protein 1 (LRP-1) in inflammatory pathways, nerve nerve degeneration and -regeneration and in neuropathic pain. Induction of LRP-1 is able to reduce the activation of the proinflammatory NFκB-mediated pathway and the mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase and p38 signaling pathways, in turn decreasing the production of inflammatory mediators. Low-density lipoprotein receptor-related protein 1 activation also decreases reactive astrogliosis and polarizes microglial cells and macrophages from a proinflammatory phenotype (M1) to an anti-inflammatory phenotype (M2), attenuating the neuroinflammatory environment. Read More

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PEER systematic review of randomized controlled trials: Management of chronic neuropathic pain in primary care.

Can Fam Physician 2021 May;67(5):e130-e140

Nurse in Edmonton and Clinical Evidence Expert for the College of Family Physicians of Canada.

Objective: To determine the proportion of patients with neuropathic pain who achieve a clinically meaningful improvement in their pain with the use of different pharmacologic and nonpharmacologic treatments.

Data Sources: MEDLINE, EMBASE, the Cochrane Library, and a gray literature search.

Study Selection: Randomized controlled trials that reported a responder analysis of adults with neuropathic pain-specifically diabetic neuropathy, postherpetic neuralgia, or trigeminal neuralgia-treated with any of the following 8 treatments: exercise, acupuncture, serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), topical rubefacients, opioids, anticonvulsant medications, and topical lidocaine. Read More

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Associations of Microvascular Complications With the Risk of Cardiovascular Disease in Type 1 Diabetes.

Diabetes Care 2021 May 12. Epub 2021 May 12.

Biostatistics Center, Milken Institute School of Public Health, The George Washington University, Rockville, MD.

Objective: We examined whether the presence of microvascular complications was associated with increased subsequent risk of cardiovascular disease (CVD) among participants with type 1 diabetes in the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study followed for >35 years.

Research Design And Methods: Standardized longitudinal data collection included: ) stereoscopic seven-field retinal fundus photography centrally graded for retinopathy stage and clinically significant macular edema; ) urinary albumin excretion rate (AER) and estimated glomerular filtration rate (eGFR); ) cardiovascular autonomic neuropathy (CAN) reflex testing; and ) adjudicated CVD events, including death from CVD, nonfatal myocardial infarction, stroke, subclinical myocardial infarction on electrocardiogram, confirmed angina, or coronary artery revascularization. Cox proportional hazard models assessed the association of microvascular complications with subsequent risk of CVD. Read More

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Ozone therapy as an alternative method for the treatment of diabetic foot ulcer: a case report.

J Med Case Rep 2021 May 13;15(1):234. Epub 2021 May 13.

Department of Medical-Surgical Nursing, Nursing and Midwifery Faculty, School of Nursing and Midwifery, Urmia University of Medical Sciences, Campus Nazlu, 11 KM Road Seru, 575611-5111, Urmia, West Azerbaijan, Iran.

Background: Diabetic foot ulcer (DFU) is one of the most important complications of diabetes that can lead to amputation. Treatment of DFUs is a major challenge and places a heavy economic and social burden on patients and their families.

Case Presentation: The present case report is of a 52-year-old kurdish male patient with a 7-year history of type 2 diabetes. Read More

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Diabetic Cystopathy Occurs Independently from Other Atherosclerotic Risks.

Case Rep Neurol 2021 Jan-Apr;13(1):200-204. Epub 2021 Mar 19.

Neurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan.

It has not yet been clarified whether atherosclerotic risks other than diabetes are related to bladder small fiber neuropathy (cystopathy) in type 2 diabetes. The aim of this study was to answer this question by urodynamics. This was a retrospective study. Read More

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Regulatory T cells in diabetes mellitus.

Hum Gene Ther 2021 May 11. Epub 2021 May 11.

Shandong University Qilu Hospital, 91623, wenhua xi road, Jinan, China, 250012;

Immune system dysfunction causes dysregulation of immune homeostasis, which in turn leads to autoimmune diseases. Regulatory T cells (Tregs) are a specialized T-cell subpopulation that maintain peripheral tolerance and immune homeostasis. Diabetic patients are at an increased risk of developing cardiovascular diseases; thus, in terms of coronary risk, diabetes mellitus (DM) is considered coronary heart disease equivalent. Read More

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Disease related changes in vocal parameters of patients with type 2 diabetes mellitus.

Logoped Phoniatr Vocol 2021 May 10:1-7. Epub 2021 May 10.

Department of Otolaryngology, Gazi University, Ankara, Turkey.

Background: As the duration of diabetes progresses, various disease related complications might occur in patients. The main goal of this paper is to compare acoustic and aerodynamic measures of patients with type 2 diabetes mellitus (T2DM) with a control group of healthy subjects.

Methods: A total of 91 subjects, 51 individuals with type 2 diabetes mellitus (DM group) and 40 healthy volunteers (HV group) were participated in the study. Read More

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The Impact of Glycemic Control on Retinal Photoreceptor Layers and Retinal Pigment Epithelium in Patients With Type 2 Diabetes Without Diabetic Retinopathy: A Follow-Up Study.

Front Endocrinol (Lausanne) 2021 23;12:614161. Epub 2021 Apr 23.

Diabetes and Vascular Research Centre (DVRC), NIHR Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, United Kingdom.

Aims: To establish the sequential changes by glycemic control in the mean thickness, volume and reflectance of the macular photoreceptor layers (MPRLs) and retinal pigment epithelium in patients with type 2 diabetes without diabetic retinopathy.

Methods: Thirty-one poorly controlled (HbA1c > 8.0%) patients with type 2 diabetes without diabetic retinopathy undergoing glycemic control and 39 control subjects with normal HbA1c levels (< 5. Read More

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Association of toe-extension movement pattern magnitude and variability during three functional tasks with diabetic foot complications.

Clin Biomech (Bristol, Avon) 2021 May 3;85:105371. Epub 2021 May 3.

Program in Physical Therapy, Washington University School of Medicine in St. Louis, 4444 Forest Park Ave, St. Louis, MO 63108, USA. Electronic address:

Background: A toe-extension movement pattern may contribute to metatarsophalangeal joint deformity and ulceration in people with diabetes. We sought to quantify the relationship between toe extension magnitude and variability during three functional tasks (ankle range of motion, sit to stand, walking) with metatarsophalangeal joint deformity, and identify potential mechanisms associated with a toe-extension movement pattern.

Methods: Individuals with diabetes and peripheral neuropathy were included (n = 60). Read More

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Whole plantar nerve conduction study: a new tool for early diagnosis of peripheral diabetic neuropathy.

Diabetes Res Clin Pract 2021 May 6:108856. Epub 2021 May 6.

Division of Internal Medicine, Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Piazza Luigi Miraglia 2, I-80138, Naples, Italy. Electronic address:

Aims: Peripheral neuropathy (PN) affects two-thirds of type 2 diabetes patients (T2DM). According to diabetic PN length-dependent pattern, neurophysiological evaluation of foot-sole nerves might increase NCS diagnostic sensitivity, hence allowing early diagnosis of PN. Thus, we aim to assess the ability of whole plantar nerve (WPN) conduction in diabetic PN early diagnosis. Read More

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Corneal Confocal Microscopy: A Biomarker for Diabetic Peripheral Neuropathy.

Clin Ther 2021 May 5. Epub 2021 May 5.

Research Division, Weill Cornell Medicine-Qatar, Doha, Qatar; Faculty of Biology, Medicine and Health, University of Manchester, Cardiovascular Trials Unit, Manchester University NHS Foundation Trust, Manchester, United Kingdom. Electronic address:

Purpose: Diagnosing early diabetic peripheral neuropathy remains a challenge due to deficiencies in currently advocated end points. The cornea is densely innervated with small sensory fibers, which are structurally and functionally comparable to intraepidermal nerve fibers. Corneal confocal microscopy is a method for rapid, noninvasive scanning of the living cornea with high resolution and magnification. Read More

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IMPROVEMENT OF TREATMENT OF COMPLICATED FORMS OF DIABETIC FOOT SYNDROME.

Georgian Med News 2021 Mar(312):27-31

Bukovinian State Medical University, Chernivtsi, Ukraine.

Considering an increasing the incidence of diabetes mellitus, the aim of the study was to improve the results of treatment of patients with diabetic foot syndrome due to the proposed complex VAC-associated therapy. The use of this method within 5 days of treatment was increased the local blood flow of the wounds from 26-31 to 49-53 mm Hg (p<0.01), while in the comparison group the blood flow was at the level of 32-37 mm Hg. Read More

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Alpha 1 adrenoceptor expression in skin, nerves and blood vessels of patients with painful diabetic neuropathy.

Auton Neurosci 2021 May 3;234:102814. Epub 2021 May 3.

College of Science, Health, Engineering and Education, Murdoch University, Perth, Western Australia, Australia.

Diabetic neuropathy (dNP) patients often suffer from severe neuropathic pain. It was suggested that alpha-1 adrenoceptor (α-AR) hyperresponsiveness contributes to pain in dNP. The aim of our study was to quantify α-AR expression using immunohistochemistry in skin biopsies of nine patients with painful diabetic neuropathy compared to 10 healthy controls. Read More

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Cross-Cultural Adaptation and Reliability Testing of Arabic Versions of Several Diabetic Foot Psychosocial Scales.

Int J Low Extrem Wounds 2021 May 7:15347346211016699. Epub 2021 May 7.

1969Queensland University of Technology, Brisbane, Queensland, Australia.

The main aims of this study were cross-cultural adaptation and reliability testing of an Arabic version of Foot Care Confidence Scale (FCCS), Foot Care Outcomes Expectations Scale (FCOES), Patient Interpretation of Neuropathy Scales (PINS), Neuropathy-specific Quality of Life Scales (NQOLS), and offloading-related Visual Analog Scales (VAS). Two phases of translation and reliability testing were conducted in Jordan. Phase 1 included 2 forward and backward translations with 2 panel consensuses (translators, clinicians, and experts). Read More

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Dual-Tasking Effects on Gait and Turning Performance of Stroke Survivors with Diabetic Peripheral Neuropathy.

Malays J Med Sci 2021 Apr 21;28(2):63-71. Epub 2021 Apr 21.

Centre for Physiotherapy Studies, Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam, Selangor, Malaysia.

Background: Stroke survivors depend on the unaffected leg during walking and standing. The presence of diabetic peripheral neuropathy (DPN) affecting both legs may further affect the postural balance and gait instability and increase the risk for falls in such patients. Thus, this study was conducted to investigate the effect of dual taskings on the gait and turning performance of stroke survivors with DPN. Read More

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miR-125a-5p in astrocytes attenuates peripheral neuropathy in type 2 diabetic mice through targeting TRAF6.

Endocrinol Diabetes Nutr 2021 May 3. Epub 2021 May 3.

Department of Neurology, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan City, Hubei Province 430081, China. Electronic address:

Introduction: Elimination or blocking of astrocytes could ameliorate neuropathic pain in animal models. MiR-125a-5p, expressed in astrocyte derived extracellular vesicles, could mediate astrocyte function to regulate neuron communication. However, the role of miR-125a-5p in DPN (diabetic peripheral neuropathy) remains elusive. Read More

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Qualitative study of musculoskeletal tissues and their radiographic correlates in diabetic neuropathic foot deformity.

Foot (Edinb) 2021 May 3;47:101777. Epub 2021 May 3.

Mallinckrodt Institute of Radiology, Musculoskeletal Section, Washington University School of Medicine, Campus Box 8131, St. Louis, MO 63110, United States. Electronic address:

Background: Diabetes mellitus (DM) with peripheral neuropathy (PN) results in foot deformity increasing ulceration, joint dislocation, and amputation risk. This study describes the frequency and severity of foot and ankle musculoskeletal abnormalities and their relationship to radiographic alignment in people with DMPN with (DMPN + MCD) and without (DMPN - MCD) medial column deformity (MCD) compared to age- and body mass index-matched controls without DMPN or MDC.

Methods: DMPN + MCD (n = 11), DMPN - MCD (n = 12), and controls (n = 12) were studied. Read More

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Using Manchester Scale classification of Hallux Valgus as a valuable tool in determining appropriate risk categorization during initial diabetic foot screening in primary health care settings.

Foot (Edinb) 2021 Apr 19;47:101810. Epub 2021 Apr 19.

Dufferin Area Family Health Team (DAFHT), 140 Rolling Hills Dr., Upper Level, Orangeville Ontario, L9W 4X8, Canada. Electronic address:

Limitations have been identified in the current state of primary care practises with regards to identifying and correctly categorizing foot deformity and its associated risk of developing foot ulcers in patients with diabetes. This study aims to bridge these gaps through the implementation of additional categorization tools to be made available for primary care professionals. This study thus analysed the relationship between foot pressure distribution and amount in patients with diabetes with Hallux Valgus foot deformity, and its different stages, in order to better understand the clinical applications of the Manchester Scale. Read More

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