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    Demographic features and visual outcomes of patients presenting to diabetic photo-screening and treated for sight threatening retinopathy in Fiji.
    Int J Ophthalmol 2017 18;10(5):790-795. Epub 2017 May 18.
    Department of Ophthalmology, New Zealand National Eye Centre, University of Auckland, Auckland 1023, New Zealand.
    Aim: To describe the demographic features and visual outcomes of patients presenting to photo-screening services, and treated for sight threatening retinopathy (STR) in a low resource setting, Fiji.

    Methods: A retrospective review of all new patients who presented for diabetic photo-screening at the Diabetic Eye Clinic, Suva in 2010. Fundus images were graded using standardised guidelines. Read More

    Enhanced dissolution and skin permeation profiles of epalrestat with β-cyclodextrin derivatives using a cogrinding method.
    Eur J Pharm Sci 2017 May 22. Epub 2017 May 22.
    Laboratory of Pharmaceutics, School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan.
    Epalrestat (EPL) is a water-insoluble drug (14μM) that inhibits aldose reductase. This study investigated the interactions between β-cyclodextrin (CD) derivatives and EPL to determine the solubilizing effect on EPL from phase solubility diagrams. We improved the solubility of EPL in water by adding β-CD derivatives. Read More

    Effects of Dangguibuxue decoction on rat glomerular mesangial cells cultured under high glucose conditions.
    BMC Complement Altern Med 2017 May 25;17(1):283. Epub 2017 May 25.
    Department of Integrated Traditional Chinese and Western Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, 430071, China.
    Background: Dysfunction of glomerular mesangial cells (GMCs) plays an important role in pathogenesis of diabetic nephropathy. Here, we investigated the effects of Dangguibuxue decoction (DBD), an herbal traditional Chinese medicinal (TCM) formula composed of Astragali Radix and Angelicae Sinensis Radix, on GMC proliferation and fibrogenesis under high-glucose (HG) conditions.

    Methods: Sixty male Sprague Dawley rats were divided into 5 groups and administered intragastric 0. Read More

    Incidence and risk factors for developing infection in patients presenting with uninfected diabetic foot ulcers.
    PLoS One 2017 17;12(5):e0177916. Epub 2017 May 17.
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
    Objective: There is a paucity of research on patients presenting with uninfected diabetic foot ulcers (DFU) that go on to develop infection. We aimed to investigate the incidence and risk factors for developing infection in a large regional cohort of patients presenting with uninfected DFUs.

    Methods: We performed a secondary analysis of data collected from a validated prospective state-wide clinical diabetic foot database in Queensland (Australia). Read More

    Clinical usefulness of videocapillaroscopy and selected endothelial cell activation markers in people with Type 1 diabetes mellitus complicated by microangiopathy.
    Adv Med Sci 2017 May 22;62(2):368-373. Epub 2017 May 22.
    Department of Rehabilitation, Medical University of Bialystok, Poland. Electronic address:
    Purpose: Microvascular abnormalities are one of the most important causes of persistent diabetic complications. The aim of our study was to compare microvascular changes examined by nailfold videocapillaroscopy (NVC) examination with serum concentrations of vascular endothelial growth factor (VEGF), soluble thrombomodulin (sTM) and endothelin-1 (ET-1) in people with Type 1 diabetes with and without microangiopathy.

    Material/methods: The study included 106 people with Type 1 diabetes and 40 healthy controls. Read More

    Preconditioning of adipose tissue-derived mesenchymal stem cells with deferoxamine increases the production of pro-angiogenic, neuroprotective and anti-inflammatory factors: Potential application in the treatment of diabetic neuropathy.
    PLoS One 2017 19;12(5):e0178011. Epub 2017 May 19.
    Centro de Medicina Regenerativa, Facultad de Medicina Clínica Alemana-Universidad del Desarrollo. Av. Las Condes, Santiago, Chile.
    Diabetic neuropathy (DN) is one of the most frequent and troublesome complications of diabetes mellitus. Evidence from diabetic animal models and diabetic patients suggests that reduced availability of neuroprotective and pro-angiogenic factors in the nerves in combination with a chronic pro-inflammatory microenvironment and high level of oxidative stress, contribute to the pathogenesis of DN. Mesenchymal stem cells (MSCs) are of great interest as therapeutic agents for regenerative purposes, since they can secrete a broad range of cytoprotective and anti-inflammatory factors. Read More

    Advances in the management of diabetic neuropathy.
    Minerva Med 2017 May 25. Epub 2017 May 25.
    First Department of Medicine, Semmelweis University, Budapest, Hungary.
    The authors review current advances in the therapy of diabetic neuropathy. The role of glycaemic control and management of cardiovascular risk factors in the prevention and treatment of neuropathic complications are discussed. As further options of pathogenetic ally oriented treatment, recent knowledge on benfotiamine and alpha-lipoic acid is comprehensively reviewed. Read More

    Magnesium Supplementation and the Effects on Wound Healing and Metabolic Status in Patients with Diabetic Foot Ulcer: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Biol Trace Elem Res 2017 May 24. Epub 2017 May 24.
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, IR, Iran.
    Hypomagnesemia is associated with the development of neuropathy and abnormal platelet activity, both of which are risk factors for diabetic foot ulcer (DFU). This study was carried out to evaluate the effects of magnesium administration on wound healing and metabolic status in subjects with DFU. This randomized, double-blind, placebo-controlled trial was performed among 70 subjects with grade 3 DFU. Read More

    Dual Delivery of NGF and bFGF Coacervater Ameliorates Diabetic Peripheral Neuropathy via Inhibiting Schwann Cells Apoptosis.
    Int J Biol Sci 2017 16;13(5):640-651. Epub 2017 May 16.
    WZMU-JCU Joint Research Group for Stem Cell and Tissue Engineering, Institute of Stem Cell and Tissue Engineering, School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.
    Diabetic neuropathy is a kind of insidious complications that impairs neural and vascular function and ultimately leads to somatic and visceral denervation. Basic fibroblast growth factor (bFGF) and nerve growth factor (NGF) are important neurotrophic factors for stimulating angiogenesis and improving peripheral nerve function. Administrating a single factor has good therapeutic effect on diabetic peripheral neuropathy (DPN). Read More

    The Different Dynamic Changes of Nerve Growth Factor in the Dorsal Horn and Dorsal Root Ganglion Leads to Hyperalgesia and Allodynia in Diabetic Neuropathic Pain.
    Pain Physician 2017 May;20(4):E551-E561
    Peking University People's Hospital & Peking University International Hospital, Beijing, China.
    Background: Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes and more than half of the patients with DPN have self-reported symptoms referring to painful diabetic neuropathy (PDN). Nerve growth factor (NGF) is a key factor for the nervous system, but the role of it in the neuropathic pain of diabetic patients is unclear.

    Objective: This study aimed to investigate the relationship between the dynamic expression of NGF in dorsal horn and dorsal root ganglion (DRG) of diabetic rats and hyperalgesia and allodynia in diabetic neuropathic pain. Read More

    Effects of acetyl-L-carnitine in diabetic neuropathy and other geriatric disorders.
    Aging Clin Exp Res 2017 May 22. Epub 2017 May 22.
    Department of Medicine - DIMED, University of Padova, Padova, Italy.
    A long history of diabetes mellitus and increasing age are associated with the onset of diabetic neuropathy, a painful and highly disabling complication with a prevalence peaking at 50% among elderly diabetic patients. Acetyl-L-carnitine (ALC) is a molecule derived from the acetylation of carnitine in the mitochondria that has an essential role in energy production. It has recently been proposed as a therapy to improve the symptoms of diabetic neuropathy. Read More

    Prevalence of overactive bladder and its impact on quality of life in 1025 patients with type 2 diabetes in mainland China.
    J Diabetes Complications 2017 May 10. Epub 2017 May 10.
    School of Nursing, Shandong University, Jinan, Shandong Province, China. Electronic address:
    Aims: This study examined the prevalence of overactive bladder (OAB) and investigated the impact of OAB on quality of life (QOL) in patients with type 2 diabetes in Mainland China.

    Methods: A total of 1025 patients with type 2 diabetes were surveyed. Patients were grouped into no OAB, dry OAB, and wet OAB groups according to the presence of OAB and urge incontinence. Read More

    Novel biological therapies for the treatment of diabetic foot ulcers.
    Expert Opin Biol Ther 2017 May 22. Epub 2017 May 22.
    e Department of Anatomy, College of Medicine & Health Sciences , United Arab Emirates University , Al Ain , United Arab Emirates.
    Introduction: The number of people with diabetes mellitus (DM) is estimated to exceed 640 million by the year 2040. Diabetic foot ulcer (DFU) is a debilitating illness that affects more than 2% of DM patients. DFU is caused by DM-induced neural and vascular lesions leading to a reduced sensation and microcirculation. Read More

    Morphine for chronic neuropathic pain in adults.
    Cochrane Database Syst Rev 2017 May 22;5:CD011669. Epub 2017 May 22.
    Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, UK, OX3 7LE.
    Background: Neuropathic pain, which is caused by a lesion or disease affecting the somatosensory system, may be central or peripheral in origin. Neuropathic pain often includes symptoms such as burning or shooting sensations, abnormal sensitivity to normally painless stimuli, or an increased sensitivity to normally painful stimuli. Neuropathic pain is a common symptom in many diseases of the nervous system. Read More

    Is Fish Oil a Potential Treatment for Diabetic Peripheral Neuropathy?
    Curr Diabetes Rev 2017 May 22. Epub 2017 May 22.
    Department of Internal Medicine, University of Iowa, Iowa City, IA, 52242 . United States.
    Background: Peripheral neuropathy affects about 50% of the diabetic population. The manifestations range from pain, numbness, paresthesia and ulceration in the extremities and it is the major cause of non-traumatic amputations. Currently there is no effective treatment for peripheral neuropathy. Read More

    Diabetes Update: Prevention and Management of Diabetes Complications.
    FP Essent 2017 May;456:36-40
    University of Tennessee Health Science Center Department of Medical Education, 920 Madison Building 7th floor, Memphis, TN 3816-30000.
    Macrovascular complications of diabetes include cardiovascular events, whereas common microvascular complications include neuropathy, retinopathy, and diabetic kidney disease. Control of hypertension and dyslipidemia is an important step in minimizing the risk of complications. Blood pressure (BP) levels should be maintained at less than 140 mm Hg systolic and less than 90 mm Hg diastolic. Read More

    Association between the risk of falls and osteoporotic fractures in patients with type 2 diabetes mellitus.
    Endocr J 2017 May 19. Epub 2017 May 19.
    Internal Medicine 1, Shimane University Faculty of Medicine, Izumo 693-8501, Japan.
    Diabetes mellitus is associated with an increased risk of falls, which increases the incidence of osteoporotic fractures and accordingly decreases quality of life. However, the association between fall risk and diabetic complications is not completely understood. Therefore, the aim of this study was to examine the association between fall risk and osteoporotic fractures in patients with type 2 diabetes mellitus (T2DM). Read More

    Measurement of electrochemical conductance of penile skin using Sudoscan(®): A new tool to assess neurogenic impotence.
    Neurophysiol Clin 2017 May 18. Epub 2017 May 18.
    EA 4391, faculté de médecine de Créteil, université Paris Est Créteil, 94010 Créteil, France; Service de physiologie-explorations fonctionnelles, hôpital Henri-Mondor, Assistance publique-Hôpitaux de Paris, 94010 Créteil, France. Electronic address:
    Objectives: To investigate the value of electrochemical skin conductance (ESC) measurement at penile level using Sudoscan(®) for the diagnosis of neurogenic impotence in diabetics.

    Methods: The following neurophysiological parameters were assessed in 25 male diabetics who complained of impotence and 25 age-matched normal male subjects without erectile dysfunction (age range: 29-70 years): ESC, sympathetic skin responses (SSR), warm detection thresholds (WDT), and cold detection thresholds (CDT) for the penis and the feet, vibration detection thresholds (VDT) for the penis, and sensory nerve conduction study of the dorsal nerve of the penis (DNP) with sensory nerve action potential (SNAP) recording.

    Results: Diabetic patients with impotence differed from controls with regard to most neurophysiological results at both penile and foot levels. Read More

    Isoliquiritigenin reduces oxidative damage and alleviates mitochondrial impairment by SIRT1 activation in experimental diabetic neuropathy.
    J Nutr Biochem 2017 May 11;47:41-52. Epub 2017 May 11.
    Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Hyderabad, Bala Nagar, India. Electronic address:
    Sirtuin (SIRT1) inactivation underlies the pathogenesis of insulin resistance and hyperglycaemia-associated vascular complications, but its role in diabetic neuropathy (DN) has not been yet explored. We have evaluated hyperglycaemia-induced alteration of SIRT1 signalling and the effect of isoliquiritigenin (ILQ) on SIRT1-directed AMP kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) signalling in peripheral nerves of streptozotocin (STZ) (55 mg/kg, ip)-induced diabetic rats and in high glucose (30 mM)-exposed neuro2a (N2A) cells. Diabetic rats and high glucose-exposed N2A cells showed reduction in SIRT1 expression with consequent decline in mitochondrial biogenesis and autophagy. Read More

    Obstructive Sleep Apnea and Diabetes: A State-of-the-Art Review.
    Chest 2017 May 17. Epub 2017 May 17.
    Section of Pulmonary and Critical Care, Sleep Disorders Center, Department of Medicine, The University of Chicago, Chicago, Illinois, U.S.A. Electronic address:
    Obstructive sleep apnea (OSA) is a chronic treatable sleep disorder and a frequent comorbidity in patients with type 2 diabetes. Cardinal features of OSA, including intermittent hypoxemia and sleep fragmentation, have been linked to abnormal glucose metabolism in laboratory-based experiments. OSA has also been linked to the development of incident type 2 diabetes. Read More

    Microvascular Complications Associated With Rapid Improvements in Glycemic Control in Diabetes.
    Curr Diab Rep 2017 Jul;17(7):48
    , 1101 Beacon St. 8W, Brookline, MA, 02446, USA.
    Purpose Of Review: Aggressive glycemic control has become the standard clinical approach to diabetes care. Unintended consequences have included the development of microvascular complications that are related to the rapidity of glycemic improvement.

    Recent Findings: Diabetic neuropathy may develop in up to 10% of individuals secondary to aggressive glycemic control. Read More

    Diagnostic Ultrasound of the Vagus Nerve in Patients with Diabetes.
    J Neuroimaging 2017 May 19. Epub 2017 May 19.
    Department of Physical Medicine & Rehabilitation, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
    Background And Purpose: Autonomic neuropathy is a serious and common complication of diabetes mellitus. The vagus nerve is the longest autonomic nerve, and may be affected in diabetes as a part of generalized neuropathy. Our objective was to assess for possible sonographic changes of the vagus nerve in diabetic patients. Read More

    SGLT2 Inhibitors as a Therapeutic Option for Diabetic Nephropathy.
    Int J Mol Sci 2017 May 18;18(5). Epub 2017 May 18.
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan.
    Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD) worldwide. Glycemic and blood pressure (BP) control are important but not sufficient to attenuate the incidence and progression of DN. Sodium-glucose cotransporter (SGLT) 2 inhibitors are a new class of glucose-lowering agent suggested to exert renoprotective effects in glucose lowering-dependent and independent fashions. Read More

    Effects of nurse telesupport on transition between specialized and primary care in diabetic patients: study protocol for a randomized controlled trial.
    Trials 2017 May 18;18(1):222. Epub 2017 May 18.
    Post Graduate Program in Medical Sciences - Division of Endocrinology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
    Background: According to the Global Diabetes Plan, a unified health system with preventive and educational strategies is essential to proper diabetes care and primary settings should be the main site of care. In Brazil, there is limited access to outpatient hospital diabetes services, while primary-care diabetes support is underutilized. Telemedicine can be a useful adjunct to support discharge of stable patients with type 2 diabetes to the primary care setting. Read More

    Clinical characteristics and risk factors of diabetic peripheral neuropathy of type 1 diabetes mellitus patients.
    Diabetes Res Clin Pract 2017 Apr 25;129:97-104. Epub 2017 Apr 25.
    Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China. Electronic address:
    Background: Small nerve fibers are more easily injured than large ones for diabetic peripheral neuropathy (DPN). The study investigated the characteristics and related risk factors of DPN of T1DM patients using nerve conduction velocity and CPT values, which provided evidences for its early diagnosis.

    Methods: 70 T1DM patients and 48 healthy volunteers were included. Read More

    Effect of omega-3 supplementation on neuropathy in type 1 diabetes: A 12-month pilot trial.
    Neurology 2017 May 17. Epub 2017 May 17.
    From the Department of Nutritional Sciences (E.J.H.L., R.P.B., T.M.S.W.), Faculty of Medicine, University of Toronto; Leadership Sinai Centre for Diabetes (B.A.P., L.E.L.), Mount Sinai Hospital, Toronto; and Ellen and Martin Prosserman Centre for Neuromuscular Diseases (V.B.), Division of Neurology, University Health Network, Toronto, Canada.
    Objective: To test the hypothesis that 12 months of seal oil omega-3 polyunsaturated fatty acids (ω-3 PUFA) supplementation will stop the known progression of diabetic sensorimotor polyneuropathy (DSP) in type 1 diabetes mellitus (T1DM).

    Methods: Individuals with T1DM and evidence of DSP as determined by a Toronto Clinical Neuropathy Score ≥1 were recruited to participate in a single-arm, open-label trial of seal oil ω-3 PUFA supplementation (10 mL·d(-1); 750 mg eicosapentaenoic acid, 560 mg docosapentaenoic acid, and 1,020 mg docosahexaenoic acid) for 1 year. The primary outcome was the 1-year change in corneal nerve fiber length (CNFL) measured by in vivo corneal confocal microscopy, with sensory and nerve conduction measures as secondary outcomes. Read More

    An Optical-Fiber-Based Smart Textile (Smart Socks) to Manage Biomechanical Risk Factors Associated With Diabetic Foot Amputation.
    J Diabetes Sci Technol 2017 May 1:1932296817709022. Epub 2017 May 1.
    2 Southern Arizona Limb Salvage Alliance (SALSA), Department of Surgery, University of Arizona, Tucson, Arizona, USA.
    Objective: This study aimed to validate a smart-textile based on fiber-optics for simultaneous measurement of plantar temperature, pressure, and joint angles in patients with diabetic peripheral neuropathy (DPN).

    Methods: After in-vitro validation in the laboratory, 33 eligible subjects with DPN were recruited (age: 58 ± 8 years, BMI: 31.5 ± 8 kg/m(2)) for assessing plantar pressure and temperature during habitual gait-speed in a clinical-setting. Read More

    Low-Dose Pulsatile Interleukin-6 As a Treatment Option for Diabetic Peripheral Neuropathy.
    Front Endocrinol (Lausanne) 2017 2;8:89. Epub 2017 May 2.
    FirstString Research, Mt. Pleasant, SC, USA.
    Diabetic peripheral neuropathy (DPN) remains one of the most common and serious complications of diabetes. Currently, pharmacological agents are limited to treating the pain associated with DPN, and do not address the underlying pathological mechanisms driving nerve damage, thus leaving a significant unmet medical need. Interestingly, research conducted using exercise as a treatment for DPN has revealed interleukin-6 (IL-6) signaling to be associated with many positive benefits such as enhanced blood flow and lipid metabolism, decreased chronic inflammation, and peripheral nerve fiber regeneration. Read More

    Autoimmune autonomic ganglionopathy manifesting as acute-onset orthostatic hypotension in a patient undergoing peritoneal dialysis.
    CEN Case Rep 2016 May 23;5(1):5-10. Epub 2015 Apr 23.
    Division of Nephrology, Matsuyama Red Cross Hospital, Matsuyama, Japan.
    Orthostatic hypotension is an important complication in the management of patients receiving dialysis therapy. As for the orthostatic hypotension caused by decreased peripheral artery resistance, diabetic neuropathy and amyloidosis are the two main causes of hypotension in dialysis patients. However, some patients develop orthostatic hypotension that is caused by dysfunction of the autonomic nervous system, not by diabetic or amyloidosis-related neuropathy. Read More

    Effect of ramipril/hydrochlorothiazide and ramipril/canrenone combination on atrial fibrillation recurrence in hypertensive type 2 diabetic patients with and without cardiac autonomic neuropathy.
    Arch Med Sci 2017 Apr 22;13(3):550-557. Epub 2016 Sep 22.
    Interinstitutional Center of Neurological Medicine, IRCCS C. Mondino National Neurological Institute, Pavia, Italy.
    Introduction: The aim of this study was to compare the effect of ramipril/canrenone versus ramipril/hydrochlorothiazide (HCTZ) combination on atrial fibrillation (AF) recurrence in type 2 diabetic hypertensives with and without cardiac autonomic neuropathy (CAN).

    Material And Methods: A total of 289 hypertensive type 2 diabetic patients, 95 with CAN, in sinus rhythm but with at least two episodes of AF in the previous 6 months were randomized to ramipril 5 mg plus canrenone 50 mg (titrated to 10/100 mg) or to ramipril 5 mg plus HCTZ 12.5 mg (titrated to 10/25 mg) or to amlodipine 5 mg (titrated to 10 mg) for 1 year. Read More

    Chromane isolated from leaves of Dillenia indica improves the neuronal dysfunction in STZ-induced diabetic neuropathy.
    J Ethnopharmacol 2017 May 13. Epub 2017 May 13.
    M.M. College of Pharmacy, M.M. University, Mullana-Ambala, Haryana 133207, India. Electronic address:
    Ethnopharmacological Relevance: According to the Indian traditional medicine, Dillenia indica L. has shown therapeutic efficacy in various diseases. Fruits and leaves of the plant possess anti-oxidant and anti-inflammatory properties. Read More

    Perceptions of Painful Diabetic Peripheral Neuropathy in South-East Asia: Results from Patient and Physician Surveys.
    Adv Ther 2017 May 13. Epub 2017 May 13.
    Pfizer Inc, New York, NY, USA.
    There are no data on physician-patient communication in painful diabetic peripheral neuropathy (pDPN) in the Asia-Pacific region. The objective of this study was to examine patient and physician perceptions of pDPN and clinical practice behaviors in five countries in South-East Asia. Primary care physicians and practitioners, endocrinologists, diabetologists, and patients with pDPN completed separate surveys on pDPN diagnosis, impact, management, and physician-patient interactions in Hong Kong, Malaysia, the Philippines, Taiwan, and Thailand. Read More

    Complementary and Integrative Interventions for Chronic Neurologic Conditions Encountered in the Primary Care Office.
    Prim Care 2017 Jun;44(2):305-322
    Department of Neurology, Northwestern University Feinberg School of Medicine, 710 North Lake Shore Drive, Abbott Hall, 1124, Chicago, IL 60611, USA. Electronic address:
    Chronic neurologic conditions are frequently managed in the primary care setting, and patients with these conditions are increasingly seeking nonconventional treatment options. This article provides a review and summary of the evidence for some of the most commonly studied and most frequently used complementary and integrative interventions for 3 conditions managed every day in primary care offices - diabetic neuropathy, migraine, and dementia. Read More

    Type 1 diabetes mellitus care and education in China: The 3C study of coverage, cost, and care in Beijing and Shantou.
    Diabetes Res Clin Pract 2017 Feb 28;129:32-42. Epub 2017 Feb 28.
    Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, National Clinical Research Center for Metabolic Diseases, No. 139, Renmin Middle Road, Furong District, Changsha 410011, Hunan Province, China.
    Aims: The paucity of data on Type 1 diabetes in China hinders progress in care and policy-making. This study compares Type 1 diabetes care and clinical outcomes in Beijing and Shantou with current clinical guidelines.

    Methods: The 3C Study was a cross-sectional study of the clinical practices and outcomes of people with Type 1 diabetes. Read More

    MSCs Ameliorates DPN induced Cellular Pathology via [Ca(2+) ]i Homeostasis and Scavenging the Pro-inflammatory cytokines.
    J Cell Physiol 2017 May 13. Epub 2017 May 13.
    Department of Physiology, College of Medicine, King Khalid University, Abha, K.S.A.
    The MSCs of various origins are known to ameliorate or modulate cell survival strategies. We investigated, whether UCB MSCs could improve the survival of the human neuronal cells and/or fibroblast assaulted with DPN sera. The results showed, the co-culture of UCB MSCs with human neuronal cells and/or fibroblasts could effectively scavenge the pro-inflammatory cytokines TNF-α, IL-1β, IFN-γ and IL - 12 and control the pro-apoptotic expression of p53/Bax. Read More

    Association of aldose reductase gene polymorphism (C-106T) in susceptibility of diabetic peripheral neuropathy among north Indian population.
    J Diabetes Complications 2017 Apr 28. Epub 2017 Apr 28.
    Department of Endocrinology and Metabolism, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005. Electronic address:
    Aim/hypothesis: Polymorphism in aldose reductase (ALR) gene at nucleotide C(-106)T (rs759853) in the promoter region is associated with susceptibility to development of diabetic peripheral neuropathy. The aim of this study was to detect the association of the C (-106)T polymorphism of ALR gene and its frequency among patients with type 2 diabetes mellitus with and without peripheral neuropathy.

    Methods: The study subjects were divided into three groups. Read More

    Influence of Low Level Laser on Pain and Inflammation in Type 2 Diabetes Mellitus with Diabetic Dermopathy- A Case Report.
    J Cosmet Laser Ther 2017 May 11. Epub 2017 May 11.
    a Manipal University Kasturba Medical College Manipal, KMC, MANIPAL , India.
    Numerous skin lesions have been commonly observed in individuals with diabetes mellitus. The common skin manifestations of diabetes mellitus are erythrsma, xanthosmatosis, xanthelasma, pycomycetes, and cutaneous infections like furuncolosis, candidiasis, carbuncle, dermatophytosis etc.Diabetic dermopathy is the most common skin lesion found in diabetics. Read More

    The Effect of Diabetic Peripheral Neuropathy on Ground Reaction Forces during Straight Walking in Stroke Survivors.
    Rehabil Res Pract 2017 9;2017:5280146. Epub 2017 Apr 9.
    Centre of Physiotherapy, Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Puncak Alam, Selangor, Malaysia.
    Purpose. The aim of this present study was to investigate the ground reaction forces (GRFs) alterations in stroke survivors with diabetic peripheral neuropathy (DPN). Methods. Read More

    Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy.
    J Peripher Nerv Syst 2017 May 9. Epub 2017 May 9.
    Departments of Neurology and Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, 21205.
    Distal axon degeneration seen in many peripheral neuropathies is likely to share common molecular mechanisms with Wallerian degeneration. Although several studies in mouse models of peripheral neuropathy showed prevention of axon degeneration in the slow Wallerian degeneration (Wlds) mouse, the role of a recently identified player in Wallerian degeneration, Sarm1, has not been explored extensively. In this study we show that mice lacking the Sarm1 gene are resistant to distal axonal degeneration in a model of chemotherapy induced peripheral neuropathy caused by paclitaxel and a model of high fat diet induced putative metabolic neuropathy. Read More

    The Relation of Diabetes Type 2 with Sexual Function among Reproductive Age Women in Iran, a Case-Control Study.
    Adv Med 2017 6;2017:4838923. Epub 2017 Apr 6.
    Endocrinology Department, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
    Background. Diabetic patients are at the greater risk of retinopathy, nephropathy, neuropathy, and sexual dysfunction compared to the general population. Objective. Read More

    Acupuncture Treatment of Diabetic Peripheral Neuropathy in an American Indian Community.
    J Acupunct Meridian Stud 2017 Apr 3;10(2):90-95. Epub 2016 Nov 3.
    Department of Medicine, Indian Health Council Clinic, Valley Center, CA, USA.
    Diabetic peripheral neuropathy (DPN) develops in 30% of type 2 diabetes patients, increases the risk for foot ulcers and amputation, and is a significant source of disability and medical costs. Treatment remains challenging, propelling research to focus on therapeutic methods that aim to improve blood circulation or ameliorate oxidative stress that drives development of DPN. The aim of this study was to assess the effectiveness of acupuncture treatment for DPN symptoms and lower extremity arterial circulation in people with type 2 diabetes. Read More

    Nonlinear dynamics of skin blood flow response to mechanical and thermal stresses in the plantar foot of diabetics with peripheral neuropathy.
    Clin Hemorheol Microcirc 2017 May 5. Epub 2017 May 5.
    Department of Kinesiology and Community Health, Rehabilitation Engineering Lab, University of Illinois atUrbana-Champaign, Champaign, IL, USA.
    Background: Diabetic foot ulcers (DFU) are a major complication in diabetics. Impaired microvascular reactivity is a major contributor to the development of DFU and has been traditionally quantified by time-domain or frequency-domain measures of skin blood flow (SBF). These measures, however, are unable to characterize the changes of nonlinear dynamics of SBF associated with diabetes and peripheral neuropathy. Read More

    Systematic Review of Animal Models Used in Research of Origins and Treatments of Fecal Incontinence.
    Dis Colon Rectum 2017 Jun;60(6):614-626
    1 Department of Anatomy, University College Dublin School of Medicine, Dublin, Ireland 2 Section of Surgery and Surgical Specialties, University College Dublin School of Medicine and Centre for Colorectal Disease, St. Vincent's University Hospital, Dublin, Ireland.
    Background: Fecal incontinence is a common disorder, but its pathophysiology is not completely understood.

    Objective: The aim of this review is to present animal models that have a place in the study of fecal incontinence.

    Data Sources: A literature review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines performed in August 2016 revealed 50 articles of interest. Read More

    Influence of Capsaicin on Inflammatory Cytokines Induced by Lipopolysaccharide in Myoblast Cells Under In vitro Environment.
    Pharmacogn Mag 2017 Jan 7;13(Suppl 1):S26-S32. Epub 2017 Apr 7.
    Department of Animal Science and Biotechnology, Chonbuk National University, Jeonju, Republic of Korea.
    Background: ellular damage initiated by reactive oxygen species (ROS) is the main cause of numerous severe diseases and therefore for this reason, the natural antioxidants have note worthy significance in human health. Capsaicin possesses noteworthy analgesic and anti-inflammatory properties. It also possesses healing effects for treatment of arthritis, diabetic neuropathy, gastric lesions, and cardiac excitability that is why it is incorporated in creams and gels. Read More

    Can both normal and mildly abnormal albuminuria and glomerular filtration rate be a danger signal for diabetic peripheral neuropathy in type 2 diabetes mellitus?
    Neurol Sci 2017 May 6. Epub 2017 May 6.
    Department of Endocrinology, The First Affiliated Hospital of Fujian Medical University, 20 Cha Zhong Road, Fuzhou, Fujian, 350005, China.
    We aimed to investigate the potential association between urinary albumin-to-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) and diabetic peripheral neuropathy (DPN). We were especially interested in the relationship between normal or mildly abnormal UACR and eGFR with DPN. A retrospective study was performed in 1059 patients with type 2 diabetes patients from Fuzhou, China, who were seen between 2010 and 2015. Read More

    Nonsurgical Treatment of Osteomyelitis of the Hallux Sesamoids: A Case Series and Literature Review.
    J Foot Ankle Surg 2017 May - Jun;56(3):666-669
    Attending Surgeon, Department of Orthopedics, Balgrist University Hospital, Zürich, Switzerland.
    The aim of the present study was to determine the effectiveness of nonsurgical treatment for osteomyelitis of the hallucal sesamoids. Osteomyelitis of the hallucal sesamoids in young and healthy patients is rare and might originate from hematogenous spread or after a puncture wound. In diabetic patients with peripheral neuropathy, it often results from direct contiguous seeding from adjacent ulceration. Read More

    Diabetic Driving Studies-Part 3: A Comparison of Mean Brake Response Time Between Neuropathic Diabetic Drivers With and Without Foot Pathology.
    J Foot Ankle Surg 2017 May - Jun;56(3):577-580
    Associate Professor, Department of Podiatric Surgery, Temple University School of Podiatric Medicine, Philadelphia, PA. Electronic address:
    We have previously demonstrated an abnormally delayed mean brake response time and an increased frequency of abnormally delayed brake responses in a group of neuropathic diabetic drivers compared with a control group of drivers with neither diabetes nor lower extremity neuropathy. The objective of the present case-control study was to compare the mean brake response time between neuropathic diabetic drivers with and without specific diabetic foot pathology. The braking performances of the participants were evaluated using a computerized driving simulator with specific measurement of the mean brake response time and the frequency of abnormally delayed brake responses. Read More

    Diabetic Driving Studies-Part 2: A Comparison of Brake Response Time Between Drivers With Diabetes With and Without Lower Extremity Sensorimotor Neuropathy.
    J Foot Ankle Surg 2017 May - Jun;56(3):573-576
    Associate Professor, Department of Podiatric Surgery, Temple University School of Podiatric Medicine, Philadelphia, PA. Electronic address:
    We have previously demonstrated an abnormally delayed mean brake response time and an increased frequency of abnormally delayed brake responses in a group of neuropathic drivers with diabetes compared with a control group of drivers with neither diabetes nor lower extremity neuropathy. The objective of the present case-control study was to compare the mean brake response time between 2 groups of drivers with diabetes with and without lower extremity sensorimotor neuropathy. The braking performances of the participants were evaluated using a computerized driving simulator with specific measurement of the mean brake response time and the frequency of the abnormally delayed brake responses. Read More

    Diabetic Driving Studies-Part 1: Brake Response Time in Diabetic Drivers With Lower Extremity Neuropathy.
    J Foot Ankle Surg 2017 May - Jun;56(3):568-572
    Resident, Podiatric Surgical Residency Program, Temple University Hospital, Philadelphia, PA.
    Although the effect of lower extremity pathology and surgical intervention on automobile driving function has been a topic of contemporary interest, we are unaware of any analysis of the effect of lower extremity diabetic sensorimotor neuropathy on driving performance. The objective of the present case-control investigation was to assess the mean brake response time in diabetic drivers with lower extremity neuropathy compared with that of a control group and a brake response safety threshold. The driving performances of participants were evaluated using a computerized driving simulator with specific measurement of the mean brake response time and frequency of abnormally delayed brake responses. Read More

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