33,151 results match your criteria Diabetic Neuropathy


Rho-associated, coiled-coil-containing protein kinase 1 regulates development of diabetic kidney disease via modulation of fatty acid metabolism.

Kidney Int 2022 May 18. Epub 2022 May 18.

Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Dysregulation of fatty acid utilization is increasingly recognized as a significant component of diabetic kidney disease. Rho-associated, coiled-coil-containing protein kinase (ROCK) is activated in the diabetic kidney, and studies over the past decade have illuminated ROCK signaling as an essential pathway in diabetic kidney disease. Here, we confirmed the distinct role of ROCK1, an isoform of ROCK, in fatty acid metabolism using glomerular mesangial cells and ROCK1 knockout mice. Read More

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Sphingolipid metabolism plays a key role in diabetic peripheral neuropathy.

Metabolomics 2022 May 20;18(6):32. Epub 2022 May 20.

Department of Pathology, School of integrative Medicine, Tianjin University of Traditional Chinese Medicine, Jian Kang Chan Ye Yuan, Jinghai Dist, 301617, Tianjin, People's Republic of China.

Introduction: As the most common chronic complication of diabetes mellitus (DM), diabetic peripheral neuropathy (DPN) seriously affects the quality of life of DM patients. So, it is of great significance for the diagnosis and treatment of DPN. In recent years, there have been numerous studies on pathogenesis and biomarkers of DM, but there are few studies on the biomarkers of DPN. Read More

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Incidence of accidental falls and development of a fall risk prediction model among elderly patients with diabetes mellitus: A prospective cohort study.

J Clin Nurs 2022 May 20. Epub 2022 May 20.

NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.

Aims: To investigate the incidence of accidental falls and develop a fall risk prediction tool in elderly patients with diabetes mellitus.

Background: The risk of fall in elderly patients with diabetes is higher than that in the general elderly, there is fewer fall assessment tools for elderly patients with diabetes.

Design: A prospective cohort study. Read More

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Diabetes-Related Microvascular Complications - A Practical Approach.

Prim Care 2022 Jun 22;49(2):239-254. Epub 2022 Apr 22.

Department of Internal Medicine, East Carolina University, 521 Moye Boulevard, 2nd Floor, Greenville, NC 27834, USA.

Diabetes-related microvascular complications include diabetic neuropathy (eg, diabetic symmetric polyneuropathy (DSPN), cardiac autonomic neuropathy, gastroparesis, enteropathy, erectile dysfunction, female sexual dysfunction, and hypoglycemia unawareness), diabetic kidney disease (DKD), and diabetes-related eye disease (eg, diabetic retinopathy (DR) and cataract). Both diabetes duration and degree of glycemic control strongly correlate with the development of microvascular complications. The development of diabetes-related microvascular complications interferes with the patient's quality of life and poses higher health system costs. Read More

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Hippocampal proteins discovery of diabetes-induced central neuropathy based on proteomics.

Neuroreport 2022 May 20;33(8):354-362. Epub 2022 Apr 20.

College of Pharmacy, Harbin University of Commerce, Harbin, China.

Objectives: Growing evidence suggests that diabetes can cause multifactorial damage to the central nervous system (CNS) and may lead to dementia. However, the underlying mechanism of diabetes-induced central neuropathy remains sparse. In recent years, proteomics has provided better methods and means in analyzing the molecular mechanisms of disease. Read More

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Machine Learning-Based Diabetic Neuropathy and Previous Foot Ulceration Patients Detection Using Electromyography and Ground Reaction Forces during Gait.

Sensors (Basel) 2022 May 5;22(9). Epub 2022 May 5.

Department of Physics and Electronics, Dr. Ram Manohar Lohia Avadh University, Faizabad, Uttar Pradesh 224001, India.

Diabetic neuropathy (DN) is one of the prevalent forms of neuropathy that involves alterations in biomechanical changes in the human gait. Diabetic foot ulceration (DFU) is one of the pervasive types of complications that arise due to DN. In the literature, for the last 50 years, researchers have been trying to observe the biomechanical changes due to DN and DFU by studying muscle electromyography (EMG) and ground reaction forces (GRF). Read More

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Foretinib mitigates cutaneous nerve fiber loss in experimental diabetic neuropathy.

Sci Rep 2022 May 19;12(1):8444. Epub 2022 May 19.

Neuroscience and Mental Health Program, SickKids Research Institute, 686 Bay St, Toronto, ON, M5G 0A4, Canada.

Diabetes is by far, the most common cause of neuropathy, inducing neurodegeneration of terminal sensory nerve fibers associated with loss of sensation, paresthesia, and persistent pain. Foretinib prevents die-back degeneration in cultured sensory and sympathetic neurons by rescuing mitochondrial activity and has been proven safe in prospective clinical trials. Here we aimed at investigating a potential neuroprotective effect of Foretinib in experimental diabetic neuropathy. Read More

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3D printed auxetic heel pads for patients with diabetic mellitus.

Comput Biol Med 2022 May 5;146:105582. Epub 2022 May 5.

Hong Kong Community College, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

More than 422 million people worldwide suffered from diabetes mellitus (DM) in 2021. Diabetic foot is one the most critical complications resultant of DM. Foot ulceration and infection are frequently arisen, which are associated with changes in the mechanical properties of the plantar soft tissues, peripheral arterial disease, and sensory neuropathy. Read More

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Salvage of Chronic Therapy-Resistant Bilateral Charcot Foot Osteoarthropathy with Signs of Osteomyelitis.

Orthop Surg 2022 May 19. Epub 2022 May 19.

Orthopaedic Surgery, Nova Southeastern University Osteopathic Medicine College of Medicine, Ft. Lauderdale, Florida, USA.

Charcot arthropathy is an insidious condition affecting the lower limbs of diabetic patients. It is a complication of diabetic neuropathy resulting from subsequent Wallerian degeneration of the nerves. This complication may eventually lead to limb amputation and a poor patient prognosis if not diagnosed and treated successfully. Read More

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Topical clonidine for neuropathic pain in adults.

Cochrane Database Syst Rev 2022 May 19;5:CD010967. Epub 2022 May 19.

Department of Interdisciplinary Intensive Care, Jagiellonian University Collegium Medicum, Krakow, Poland.

Background: Clonidine is a presynaptic alpha-2-adrenergic receptor agonist that has been used for many years to treat hypertension and other conditions, including chronic pain. Adverse events associated with systemic use of the drug have limited its application. Topical use of drugs has been gaining interest since the beginning of the century, as it may limit adverse events without loss of analgesic efficacy. Read More

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Waist Circumference and Body Mass Index Variability and Incident Diabetic Microvascular Complications: A Post Hoc Analysis of ACCORD Trial.

Diabetes Metab J 2022 May 10. Epub 2022 May 10.

Department of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, China.

Background: Obesity is associated with adverse health events among diabetic patients, however, the relationship between obesity fluctuation and risk of microvascular complications among this specific population is unclear. We aimed to examine the effect of waist circumference (WC) and body mass index (BMI) variability on the risk of diabetic microvascular outcome.

Methods: Annually recorded anthropometric data in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study was used to examine the association of WC and BMI variability defined as variability independent of mean, with the risk of microvascular outcomes, including neuropathy, nephropathy, and retinopathy. Read More

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Effect of thermometry on the prevention of diabetic foot ulcers: a systematic review with meta-analysis.

Rev Lat Am Enfermagem 2022 ;30:e3567

Universidade Estadual do Ceará, Fortaleza, CE, Brasil.

Objective: to analyze the effect of cutaneous foot thermometry in people with Diabetes Mellitus, compared with the standard prevention of foot ulcers adopted in these patients.

Method: a systematic review with meta-analysis. Protocol registered with PROSPERO (CRD42020202686). Read More

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Study Design and Baseline Characteristics of Patients with T2DM in the Post-marketing Safety Study of Dulaglutide in China (TRUST-CHN).

Diabetes Ther 2022 May 18. Epub 2022 May 18.

Eli Lilly Suzhou Pharmaceutical Co. Ltd, Shanghai, China.

Background: TRUST-CHN is a prospective, post-marketing safety study in patients with type 2 diabetes mellitus (T2DM) in China to evaluate the safety and effectiveness of dulaglutide in real-world clinical practice. We report here the study design and baseline characteristics of enrolled patients.

Methods: The study design was described, and baseline data were analyzed, including demographic characteristics, T2DM duration, comorbidities, dulaglutide treatment patterns, and concomitant medications. Read More

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Major osteoporosis fracture prediction in type 2 diabetes: a derivation and comparison study.

Osteoporos Int 2022 May 18. Epub 2022 May 18.

Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The widely recommended fracture prediction tool FRAX was developed based on and for the general population. Although several adjusted FRAX methods were suggested for type 2 diabetes (T2DM), they still need to be evaluated in T2DM cohort.

Introduction: This study was undertaken to develop a prediction model for Chinese diabetes fracture risk (CDFR) and compare its performance with those of FRAX. Read More

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Foot Osteomyelitis Location and Rates of Primary or Secondary Major Amputations in Patients With Diabetes.

Foot Ankle Int 2022 May 18:10711007221088552. Epub 2022 May 18.

Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Background: Diabetic foot osteomyelitis (DFO) often leads to amputations in the lower extremity. Data on the influence of the initial anatomical DFO localization on ultimate major amputation are limited.

Methods: In this retrospective analysis, 583 amputation episodes in 344 patients (78 females, 266 males) were analyzed. Read More

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An overview of painful diabetic peripheral neuropathy: diagnosis and treatment advancements.

Diabetes Res Clin Pract 2022 May 14:109928. Epub 2022 May 14.

Department of Anesthesiology and Perioperative Medicine, Division of Pain Medicine, Mayo Clinic, Rochester, MN, USA.

Diabetes mellitus remains a public health problem, affecting 422 million people worldwide. Currently, there is no consensus around treating painful diabetic peripheral neuropathy in a step-wise manner. Among the non-pharmacological interventions, neuromodulation has become a promising alternative. Read More

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Glycyrrhizic acid promotes sciatic nerves recovery in type 1 diabetic rats and protects Schwann cells from high glucose-induced cytotoxicity.

J Biomed Res 2022 May 15:1-14. Epub 2022 May 15.

Key Laboratory of Human Functional Genomics of Jiangsu Province, Department of Biochemistry and Molecular Biology, Nanjing Medical University, Nanjing, Jiangsu 211166, China.

The present study aims to investigate the therapeutic effect and mechanism of glycyrrhizic acid (GA) in diabetic peripheral neuropathy (DPN). GA significantly mitigated nerve conduction velocity (NCV) deficit and morphological abnormality and reduced high-mobility group box-1 (HMGB1) expression in the sciatic nerves of diabetic rats independent of blood glucose and body weight. Notably, GA alleviated the increase of HMGB1 and the decrease of cell viability in high glucose-stimulated RSC96 cells. Read More

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Trans tibial amputation with or without a tourniquet in patients with diabetic foot infection and peripheral vascular disease: Comparison of postoperative outcomes.

J Orthop Surg (Hong Kong) 2022 May-Aug;30(2):10225536221102694

Department of Orthopedic Surgery, 26738Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.

Transtibial amputation (TTA) due to complications of diabetic foot infection (DFI) or peripheral vascular disease (PVD) is a high-risk procedure in fragile patients. The risks of reoperation, blood loss requiring blood transfusion, and mortality are high. The use of a tourniquet in this procedure is controversial and scarcely reported. Read More

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Are diabetic foot ulcers less harmful than other pressure ulcers?

Authors:
Harry Lee Penny

J Wound Care 2022 May;31(Sup5):S3-S4

University of Pittsburgh Medical Center; Director of Blair Medical Associates, UPMC Wound Clinic, Altoona, PA, US.

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Impaired Vascular Endothelial Function is Associated with Peripheral Neuropathy in Patients with Type 2 Diabetes.

Diabetes Metab Syndr Obes 2022 6;15:1437-1449. Epub 2022 May 6.

Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, Gansu, 730000, People's Republic of China.

Purpose: It is believed that vascular endothelial dysfunction is involved in the occurrence of cardiovascular disease (CVD), and diabetic peripheral neuropathy (DPN) is associated with flow-mediated dilation (FMD), however, the correlation is still unclear. Aims of the present study is to explore the relationship between DPN parameters and FMD, providing a new approach for the prevention of CVD.

Patients And Methods: A total of 272 patients with T2DM from the Department of Endocrinology of The First Hospital of Lanzhou University according to the grading criteria were selected. Read More

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The NOD Mouse Beyond Autoimmune Diabetes.

Front Immunol 2022 29;13:874769. Epub 2022 Apr 29.

Immunology-Oncology Division, Maisonneuve-Rosemont Hospital Research Center, Montreal, QC, Canada.

Autoimmune diabetes arises spontaneously in Non-Obese Diabetic (NOD) mice, and the pathophysiology of this disease shares many similarities with human type 1 diabetes. Since its generation in 1980, the NOD mouse, derived from the Cataract Shinogi strain, has represented the gold standard of spontaneous disease models, allowing to investigate autoimmune diabetes disease progression and susceptibility traits, as well as to test a wide array of potential treatments and therapies. Beyond autoimmune diabetes, NOD mice also exhibit polyautoimmunity, presenting with a low incidence of autoimmune thyroiditis and Sjögren's syndrome. Read More

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Monosodium Glutamate-Induced Mouse Model With Unique Diabetic Retinal Neuropathy Features and Artificial Intelligence Techniques for Quantitative Evaluation.

Front Immunol 2022 27;13:862702. Epub 2022 Apr 27.

National Clinical Research Centre for Chinese Medicine Cardiology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China.

Objective: To establish an artificial intelligence-based method to quantitatively evaluate subtle pathological changes in retinal nerve cells and synapses in monosodium glutamate (MSG) mice and provide an effective animal model and technique for quantitative evaluation of retinal neurocytopathies.

Methods: ICR mice were subcutaneously injected with MSG to establish a model of metabolic syndrome. We then established a mouse model of type 1 diabetes, type 2 diabetes, and KKAy mouse model as control. Read More

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Diabetic papillopathy in patients with optic disc drusen: Description of two different phenotypes.

Eur J Ophthalmol 2022 May 15:11206721221100901. Epub 2022 May 15.

Department of Ophthalmology, Rigshospitalet, Glostrup, Denmark.

Purpose: To describe two cases of severe acute bilateral optic disc edema that occurred in patients with diabetes mellitus shortly after the initiation of intensified antihyperglycemic therapy.

Methods: Retrospective observational case report.

Case Description: Two patients with type 1 diabetes presented for routine retinopathy screening with asymptomatic optic disc edema. Read More

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Development of a customized booklet of foot-ankle exercises for people with diabetes mellitus as a management and prevention tool for musculoskeletal complications: A customized booklet of foot-ankle exercises for people with diabetes.

Braz J Phys Ther 2022 Mar 31;26(3):100402. Epub 2022 Mar 31.

Department of Physical Therapy, Speech, and Occupational Therapy, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil. Electronic address:

Background: Diabetes mellitus (DM) and diabetic peripheral neuropathy (DPN) compromises the structures of the musculoskeletal system, especially in the foot-ankle complex. Foot-related exercises can be a promising tool to be incorporated in health care programs to manage and prevent musculoskeletal complications resulting from DM and DPN progression.

Objective: To present the development, validation, and usability evaluation of a booklet that directs training and personalizes the progression of a home-based program of foot-ankle exercises. Read More

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Physical Activity Participation in People With an Active Diabetic Foot Ulceration: A Scoping Review.

Can J Diabetes 2022 Apr 10;46(3):313-327. Epub 2021 Jul 10.

Department of Nursing, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada.

Background: Being physically active on a regular basis has a favourable impact on diabetes-related complications. With the exception of evidence advising individuals with an active diabetic foot ulceration (DFU) to avoid weight-bearing activity, no physical activity (PA) recommendations are currently provided for this population.

Objective: The aim of this scoping review was to examine and map the existing research evidence of PA participation for individuals with an active DFU. Read More

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Influence of Tangeretin on the Exponential Regression of Inflammation and Oxidative Stress in Streptozotocin-Induced Diabetic Nephropathy.

Appl Biochem Biotechnol 2022 May 14. Epub 2022 May 14.

Department of Kidney Disease Unit & Dialysis, Central Hospital Affiliated to Shandong First Medical University, No. 105, Jiefang Road, Jinan City, Shandong, 250013, China.

Diabetes is an amalgamation of metabolic disorders marked by hyperglycemia. Over time diabetes brings up several other complications with it like cardiovascular disease, retinopathy, neuropathy, and nephropathy. among which diabetic nephropathy (DN) is the one we are concerned about in the present study. Read More

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Validation of an autonomous artificial intelligence-based diagnostic system for holistic maculopathy screening in a routine occupational health checkup context.

Graefes Arch Clin Exp Ophthalmol 2022 May 14. Epub 2022 May 14.

Optretina Image Reading Team, Barcelona, Spain.

Purpose: This study aims to evaluate the ability of an autonomous artificial intelligence (AI) system for detection of the most common central retinal pathologies in fundus photography.

Methods: Retrospective diagnostic test evaluation on a raw dataset of 5918 images (2839 individuals) evaluated with non-mydriatic cameras during routine occupational health checkups. Three camera models were employed: Optomed Aurora (field of view - FOV 50º, 88% of the dataset), ZEISS VISUSCOUT 100 (FOV 40º, 9%), and Optomed SmartScope M5 (FOV 40º, 3%). Read More

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Using Corneal Confocal Microscopy to Identify Therapeutic Agents for Diabetic Neuropathy.

J Clin Med 2022 Apr 21;11(9). Epub 2022 Apr 21.

Department of Pathology, University of California San Diego, La Jolla, CA 92093, USA.

Corneal confocal microscopy (CCM) is emerging as a tool for identifying small fiber neuropathy in both peripheral neuropathies and neurodegenerative disease of the central nervous system (CNS). The value of corneal nerves as biomarkers for efficacy of clinical interventions against small fiber neuropathy and neurodegenerative disease is less clear but may be supported by preclinical studies of investigational agents. We, therefore, used diverse investigational agents to assess concordance of efficacy against corneal nerve loss and peripheral neuropathy in a mouse model of diabetes. Read More

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Serine Metabolism in Health and Disease and as a Conditionally Essential Amino Acid.

Authors:
Milan Holeček

Nutrients 2022 May 9;14(9). Epub 2022 May 9.

Department of Physiology, Faculty of Medicine in Hradec Králové, Charles University, Šimkova 870, 500 03 Hradec Králové, Czech Republic.

L-serine plays an essential role in a broad range of cellular functions including protein synthesis, neurotransmission, and folate and methionine cycles and synthesis of sphingolipids, phospholipids, and sulphur containing amino acids. A hydroxyl side-chain of L-serine contributes to polarity of proteins, and serves as a primary site for binding a phosphate group to regulate protein function. D-serine, its D-isoform, has a unique role. Read More

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