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    Safety of Sitagliptin in Patients with Type 2 Diabetes and Chronic Kidney Disease: Outcomes from TECOS.
    Diabetes Obes Metab 2017 Apr 22. Epub 2017 Apr 22.
    Diabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
    Aims: To characterize the incidence of diabetes-associated complications and assess the safety of sitagliptin in participants with chronic kidney disease (CKD) in the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS).

    Materials And Methods: For participants with baseline eGFR measurements (n = 14,528), baseline characteristics and safety outcomes were compared for the CKD cohort (eGFR <60 mL/min per 1.73 m(2) ) versus those without CKD. Read More

    Tangluoning, a traditional Chinese medicine, attenuates in vivo and in vitro diabetic peripheral neuropathy through modulation of PERK/Nrf2 pathway.
    Sci Rep 2017 Apr 21;7(1):1014. Epub 2017 Apr 21.
    School of Traditional Chinese Medicine, Capital Medical University and Beijing Key Lab of TCM Collateral Disease Theory Research, Beijing, China.
    Prolonged hyperglycemia-induced oxidative stress and endoplasmic reticulum stress have been demonstrated to play a key role in progression of diabetic peripheral neuropathy (DPN). PERK/ Nrf2 pathway plays a predominant role in oxidative and endoplasmic reticulum (ER) stress which is associated with cell survival. This study examined the modulation of the PERK/Nrf2 pathway and apoptosis by a traditional Chinese medicine Tangluoning (TLN) in streptozotocin-induced DPN rat models and the effects of serum TLN on the PERK/Nrf2 pathway, apoptosis, intracellular reactive oxygen species and mitochondrial membrane potential in Schwann cells cultured in 150 mM glucose. Read More

    Magnetic Resonance Neurography Visualizes Abnormalities in Sciatic and Tibial Nerves in Patients with Type 1 Diabetes and Neuropathy.
    Diabetes 2017 Apr 21. Epub 2017 Apr 21.
    Department of Neurology, Aarhus University Hospital, Denmark.
    This study evaluates whether diffusion-tensor-imaging MR-Neurography (DTI-MRN), T2-relaxation-time and proton-spin-density can detect and grade neuropathic abnormalities in patients with type 1 diabetes.Forty-nine patients with type 1 diabetes (11 with severe polyneuropathy (sDPN), 13 with mild polyneuropathy (mDPN) and 25 without polyneuropathy (nDPN)) and 30 healthy controls (HC) were included. Clinical examinations, nerve-conduction-studies and vibratory-perception-thresholds determined the presence and severity of DPN. Read More

    Experimental Anterior Ischemic Optic Neuropathy in Diabetic Mice Exhibited Severe Retinal Swelling Associated With VEGF Elevation.
    Invest Ophthalmol Vis Sci 2017 Apr;58(4):2296-2305
    Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, United States.
    Purpose: Diabetes mellitus (DM) is one of the most important risk factors for nonarteritic anterior ischemic optic neuropathy (AION). In this study, we investigated for the first time the impact of experimental AION in a DM model.

    Methods: We induced a photochemical thrombosis model of AION after streptozotocin-induced DM and performed serial optical coherence tomography (OCT), morphometric analyses, and VEGF levels in the retina and sera. Read More

    [The clinical value of SUDOSCAN in diagnosis of diabetic distal symmetrical peripheral neuropathy].
    Zhonghua Yi Xue Za Zhi 2017 Apr;97(15):1170-1174
    Department of Endocrinology, the Affiliated Hospital of Qingdao University, Qingdao 266003, China.
    Objective: To evaluate the clinical value of SUDOSCAN in diagnosis of diabetic distal symmetrical peripheral neuropathy. Methods: According to the diagnostic criteria for multiple diabetic distal symmetrical peripheral neuropathy, a total of 130 patients with type 2 diabetes mellitus (T2DM) in Department of Endocrinology, the Affiliated Hospital of Qingdao University between August 2015 and July 2016 were divided into two groups, diabetic peripheral neuropathy group (DPN group, 50 cases) and non-diabetic peripheral neuropathy group (NDPN group, 80 cases). Additional 80 healthy volunteers were selected as healthy control group (NC group). Read More

    The Eye as a Window to the Microvascular Complications of Diabetes.
    Dev Ophthalmol 2017 20;60:6-15. Epub 2017 Apr 20.
    Although microvascular complications of diabetes (retinopathy, neuropathy, and nephropathy) affect different organs, they are strongly correlated to each other. Based on recent data, their onset and progression could be directly monitored, focusing our attention only on the eye. When confirmed and standardized, this approach could allow one to simplify the way in which we follow the progression of different diabetic complications, and thus establish new strategies aimed at preventing, treating and, hopefully, inducing the remission of microvascular complications of diabetes. Read More

    The Spontaneous Autoimmune Neuromyopathy in ICOSL(-/-) NOD Mice Is CD4(+) T-Cell and Interferon-γ Dependent.
    Front Immunol 2017 31;8:287. Epub 2017 Mar 31.
    INSERM U1016, Cochin Institute, Paris Descartes University, Sorbonne Paris Cité, Paris, France.
    Abrogation of ICOS/ICOS ligand (ICOSL) costimulation prevents the onset of diabetes in the non-obese diabetic (NOD) mouse but, remarkably, yields to the development of a spontaneous autoimmune neuromyopathy. At the pathological level, ICOSL(-/-) NOD mice show stronger protection from insulitis than their ICOS(-/-) counterparts. Also, the ICOSL(-/-) NOD model carries a limited C57BL/6 region containing the Icosl nul mutation, but, in contrast to ICOS(-/-) NOD mice, no gene variant previously reported as associated to NOD diabetes. Read More

    Sex differences in micro- and macro-vascular complications of diabetes mellitus.
    Clin Sci (Lond) 2017 May;131(9):833-846
    Division of Cardiovascular Sciences, Vascular Biology and Hypertension Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, U.S.A.
    Vascular complications are a leading cause of morbidity and mortality in both men and women with type 1 (T1DM) or type 2 (T2DM) diabetes mellitus, however the prevalence, progression and pathophysiology of both microvascular (nephropathy, neuropathy and retinopathy) and macrovascular [coronary heart disease (CHD), myocardial infarction, peripheral arterial disease (PAD) and stroke] disease are different in the two sexes. In general, men appear to be at a higher risk for diabetic microvascular complications, while the consequences of macrovascular complications may be greater in women. Interestingly, in the absence of diabetes, women have a far lower risk of either micro- or macro-vascular disease compared with men for much of their lifespan. Read More

    Prevalence of type 2 diabetes and its complications in India and economic costs to the nation.
    Eur J Clin Nutr 2017 Apr 19. Epub 2017 Apr 19.
    Madras Diabetes Research Foundation and Dr Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and ICMR Centre for Advanced Research on Diabetes, Chennai, India.
    Diabetes, a major lifestyle disorder, has become a global burden, and the prevalence rates are rising steeply in developing economies. Rapid socioeconomic transition with urbanization and industrialization are the main causes for the global diabetes epidemic. Among developing economies, the highest increase in number of people with diabetes is in China followed by India. Read More

    The Preferential Impairment of Pupil Constriction Stimulated by Blue Light in Patients with Type 2 Diabetes without Autonomic Neuropathy.
    J Diabetes Res 2017 22;2017:6069730. Epub 2017 Mar 22.
    University of Exeter Medical School, Exeter, UK.
    The main aim of the present paper is to examine whether the pupillary light reflex (PLR) mediated by intrinsically photosensitive retinal ganglion cells (ipRGCs) is impaired in type 2 diabetic patients. One hundred and three diabetic patients without diabetic autonomic neuropathy (DAN) and 42 age-matched controls underwent a series of detailed neurological examinations. The patients were stratified into three groups: stage I, no neuropathy; stage II, asymptomatic neuropathy; stage III, symptomatic but without DAN. Read More

    Macrovascular Complications and Prevalence of Urgency Incontinence in Japanese Patients with Type 2 Diabetes Mellitus: The Dogo Study.
    Intern Med 2017 15;56(8):889-893. Epub 2017 Apr 15.
    Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Japan.
    Objective Macrovascular diseases and urgency incontinence are common among Japanese patients with type 2 diabetes mellitus. However, little evidence exists regarding the association between stroke and urgency incontinence among patients with type 2 diabetes mellitus. We examined the associations between macrovascular complications and urgency incontinence among Japanese patients with type 2 diabetes mellitus. Read More

    Diabetes, Associated Clinical Spectrum, Long-term Prognosis and Genotype/Phenotype Correlations in 201 Adult Patients With Hepatocyte Nuclear Factor 1 B (HNF1B) Molecular Defects.
    Diabetes Care 2017 Apr 18. Epub 2017 Apr 18.
    Department of Diabetology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, and Paris Descartes University, DHU AUTHORS, Paris, France.
    Objective: Molecular defects of hepatocyte nuclear factor 1B (HNF1B) are associated with a multiorgan disease, including diabetes (maturity-onset diabetes of the young 5) and kidney abnormalities. The HNF1B-syndrome is related to HNF1B mutations or to a 17q12 deletion spanning 15 genes, including HNF1B. Here, we described HNF1B-related diabetes and associated phenotypes and assessed genotype/phenotype correlations at diagnosis and in the long-term. Read More

    Lace Up for Healthy Feet: The Impact of Shoe Closure on Plantar Stress Response.
    J Diabetes Sci Technol 2017 Apr 1:1932296817703669. Epub 2017 Apr 1.
    1 Interdisciplinary Consortium on Advanced Motion Performance (iCAMP), Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
    Objective: This study examined the impact of shoe closure on plantar thermal stress response (TSR), which is known to be a surrogate of shear stress and skin perfusion. It is aimed to explore potential impact of shoe closure on increasing risk factors associated with plantar ulcers in people with diabetic peripheral neuropathy (DPN).

    Methods: Fifteen eligible subjects were enrolled. Read More

    Early onset symptomatic neuropathy in a child with Type 1 Diabetes mellitus.
    Diabetes Metab Syndr 2017 Apr 5. Epub 2017 Apr 5.
    Department of Medicine, MM Institute of Medical Sciences, MM University, Mullana, Ambala, Haryana, 133207, India. Electronic address:
    Diabetic neuropathy (DN) is a major complication of Type 1 Diabetes Mellitus (T1DM). It is usually subclinical in childhood, but can cause significant impairment with its progression through to adulthood. Current guidelines vary in their recommendation regarding screening for DN in children with T1DM, with some advocating starting screening 5 years after the diagnosis of T1DM. Read More

    How common are foot problems among individuals with diabetes? Diabetic foot ulcers in the Dutch population.
    Diabetologia 2017 Apr 13. Epub 2017 Apr 13.
    Department of Vascular Surgery, Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100 DD, Amsterdam, the Netherlands.
    Aims/hypothesis: Contemporary data on diabetic foot ulcer prevalence are scarce. Most studies were conducted in the 1990s, reporting incidence rates of 1.9-2. Read More

    Peripheral and Autonomic Neuropathy in South Asians and White Caucasians with Type 2 Diabetes Mellitus: Possible Explanations for Epidemiological Differences.
    J Diabetes Res 2017 20;2017:1273789. Epub 2017 Mar 20.
    Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.
    Objectives. To compare the prevalence of diabetic peripheral neuropathy (DPN) and that of cardiac autonomic neuropathy (CAN) between South Asians and White Caucasians with type 2 diabetes and to explore reasons for observed differences. Methods. Read More

    Diabetic retinopathy is a neurodegenerative disorder.
    Vision Res 2017 Apr 10. Epub 2017 Apr 10.
    Department of Ophthalmology and Visual Sciences, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA; Iowa Institute for Biomedical Imaging, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA; Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA 52242; Department of Veterans Affairs, 601 US-6, Iowa City, IA 52246, USA. Electronic address:
    Since 1875, controversy has ensued over whether ocular diabetic complications are primarily vasculopathic or neuropathic in nature. Here, we discuss the historical context by which diabetic retinopathy (DR) came to be considered a primary vasculopathy, in contrast to more recent data suggesting the importance of diabetic retinal neurodegeneration (DRN) as the primary manifestation of ocular diabetic damage. Unsurprisingly, DRN parallels other diabetic complications related to neuropathy. Read More

    Diabetic complications in the cornea.
    Vision Res 2017 Apr 9. Epub 2017 Apr 9.
    Eye Program, Board of Governors Regenerative Medicine Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center and David Geffen School of Medicine at UCLA, 8700 Beverly Boulevard, AHSP A-8106, Los Angeles 90048, CA, USA. Electronic address:
    Diabetic corneal alterations, such as delayed epithelial wound healing, edema, recurrent erosions, neuropathy/loss of sensitivity, and tear film changes are frequent but underdiagnosed complications of both type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus. The disease affects corneal epithelium, corneal nerves, tear film, and to a lesser extent, endothelium, and also conjunctiva. These abnormalities may appear or become exacerbated following trauma, as well as various surgeries including retinal, cataract or refractive. Read More

    Use of medical services and medicines attributable to type 2 diabetes care in Yaoundé, Cameroon: a cross-sectional study.
    BMC Health Serv Res 2017 Apr 11;17(1):262. Epub 2017 Apr 11.
    Department of Internal Medicine and specialties, Faculty of Medicine and Biomedical sciences, The University of Yaoundé I, Yaoundé, Cameroon.
    Background: The increasing numbers of people with type 2 diabetes (T2D) is a global concern and especially in sub-Saharan Africa, where diabetes must compete for resources with communicable diseases. Diabetes intensifies health care utilisation and leads to an increase in medical care costs. However, In Cameroon like in most developing countries, data on the impact of diabetes on the medical health system are scarce. Read More

    Antibiotic Use and Kirschner Wire Fixation in Forefoot Surgery: A National Survey.
    Orthopedics 2017 Apr 11:1-4. Epub 2017 Apr 11.
    In foot and ankle patients, the use of Kirschner wires is common, and the population in the typical foot and ankle practice has higher rates of comorbidities associated with infection. This study assessed national trends regarding the use of postoperative prophylactic antibiotic therapy in patients undergoing foot and ankle surgery treated with percutaneous Kirschner wires. Attending physicians at foot and ankle fellowships were mailed a questionnaire that included 3 clinical vignettes containing questions on the use of postoperative antibiotics in patients treated with percutaneous Kirschner wires. Read More

    Peripheral Sensory Neuropathy and associated factors among adult diabetes mellitus patients in Bahr Dar, Ethiopia.
    J Diabetes Metab Disord 2017 4;16:16. Epub 2017 Apr 4.
    Department of physiotherapy, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
    Background: Diabetic sensory neuropathy is a common form of microvascular complication among diabetic patients. The swiftly growing population of people living with diabetes in Ethiopia and lack of elaborated scientific data on peripheral sensory neuropathy among diabetic population in Ethiopia prompted this work. This study was set out to assess the enormity and associated factors of peripheral sensory neuropathy among diabetes patients attending chronic illness clinic of Felege Hiwot Regional Referral Hospital, Bahr Dar, Northwest Ethiopia. Read More

    THE USE OF ANTHROPOMETRIC MEASUREMENTS OF OBESITY IN PREDICTION OF MICROVASCULAR COMPLICATIONS IN OBESE TYPE 2 DIABETIC PATIENTS.
    Acta Clin Croat 2016 06;55(2):217-23
    Waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) are superior to body mass index (BMI) in predicting type 2 diabetes mellitus (T2DM) development. The aim of this study was to investigate the predictive power of BMI, WC, WHR and WHtR for microvascular (chronic kidney disease (CKD), retinopathy and peripheral neuropathy) prevalence in obese (BMI ≥35 kg/m2) T2DM patients. This cross-sectional study included 125 T2DM patients of both genders. Read More

    MiR-106a is associated with diabetic peripheral neuropathy through the regulation of 12/15-LOX-mediated oxidative/nitrative stress.
    Curr Neurovasc Res 2017 Apr 4. Epub 2017 Apr 4.
    Department of Neurology, Provincial Hospital Affiliated to Anhui Medical University, HeFei 230001, Anhui Province. China.
    Background: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes that with a complex pathogenesis. Study has reported that oxidative stress and nitrative stress were all involved in the DPN, however, the mechanism between them was still unclear. In the present study, we investigated whether miR-106a signaling regulated 12/15-Lipoxygenase (12/15-LOX) on oxidative/nitrative stress in DPN. Read More

    Tafamidis delays disease progression in patients with early stage transthyretin familial amyloid polyneuropathy: additional supportive analyses from the pivotal trial.
    Amyloid 2017 Apr 10:1-7. Epub 2017 Apr 10.
    a Pfizer Inc. , New York , NY , USA.
    Background: Tafamidis, a non-NSAID highly specific transthyretin stabilizer, delayed neurologic disease progression as measured by Neuropathy Impairment Score-Lower Limbs (NIS-LL) in an 18-month, double-blind, placebo-controlled randomized trial in 128 patients with early-stage transthyretin V30M familial amyloid polyneuropathy (ATTRV30M-FAP). The current post hoc analyses aimed to further evaluate the effects of tafamidis in delaying ATTRV30M-FAP progression in this trial.

    Methods: Pre-specified, repeated-measures analysis of change from baseline in NIS-LL in this trial (ClinicalTrials. Read More

    Serum chitotriosidase enzyme activity is closely related to HbA1c levels and the complications in patients with diabetes mellitus type 2.
    Diabetes Metab Syndr 2017 Mar 31. Epub 2017 Mar 31.
    Ege University, Faculty of Medicine, Dept. of Medical Biochemistry, Izmir, Turkey. Electronic address:
    Aims: Chitotriosidase, is a macrophage sourced enzyme which shows high activity during the course of various storage disorders such as Gaucher's Disease. The aforementioned macrophage sourced enzyme, which has a role in basic immune response, is also high in patients with diabetes. This study was designed to determine the chitotriosidase activities in patients with diabetes and the relationship between the complication of diabetes and chitotriosidase activity. Read More

    The impact of diabetes on mobility, balance, and recovery after repositioning maneuvers in individuals with benign paroxysmal positional vertigo.
    J Diabetes Complications 2017 Mar 22. Epub 2017 Mar 22.
    Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, KS 66160.
    Aim: The prevalence of benign paroxysmal positional vertigo (BPPV) is higher in people with type 2 diabetes (DM). The impact of DM on mobility, balance, and management of BPPV is unknown. This prospective study compared symptom severity, mobility and balance before and after the canalith repositioning maneuver (CRM) in people with posterior canal BPPV canalithiasis, with and without DM. Read More

    STZ causes depletion of immune cells in sciatic nerve and dorsal root ganglion in experimental diabetes.
    J Neuroimmunol 2017 May 11;306:76-82. Epub 2017 Mar 11.
    Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg, INF 410, Heidelberg, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstraße 1, 85764 Neuherberg, Germany. Electronic address:
    Streptozotocin (STZ) treatment, a common model for inducing diabetes in rodent models, induces thermal hyperalgesia and neuronal toxicity independently of hyperglycemia by oxidizing and activating TRPA1 and TRPV1. Following treatment with STZ, CD45(+) immune cells were found to be depleted in sciatic nerve (SN) and DRG in mice, prior to hyperglycemia. Macrophages were also lost in DRG and NFκB-p65-activation was increased in SN macrophages. Read More

    The MOBILE Study-A Phase IIa Enriched Enrollment Randomized Withdrawal Trial to Assess the Analgesic Efficacy and Safety of ASP8477, a Fatty Acid Amide Hydrolase Inhibitor, in Patients with Peripheral Neuropathic Pain.
    Pain Med 2017 Apr 5. Epub 2017 Apr 5.
    Astellas Pharma Global Development, Northbrook, Illinois, USA.
    Objective.:  To evaluate the analgesic efficacy and safety of ASP8477 in patients with peripheral neuropathic pain (PNP).

    Design. Read More

    Bioactive Fraction of Annona reticulata Bark (or) Ziziphus jujuba Root Bark along with Insulin Attenuates Painful Diabetic Neuropathy through Inhibiting NF-κB Inflammatory Cascade.
    Front Cell Neurosci 2017 22;11:73. Epub 2017 Mar 22.
    Drug Discovery Laboratory, Institute of Advanced Study in Science and TechnologyGuwahati, India; National Institute of Pharmaceutical Education and ResearchGuwahati, India.
    The present study explains the neuroprotective ability of bioactive fractions of Annona reticulata bark (ARB) and Ziziphus jujuba root bark (ZJ) along with insulin against diabetic neuropathy. By using different solvents of increasing polarity ARB and ZJ were undergone for bioactive guided fractionation. The neuroprotective ability of the all the plant fractions were tested against H2O2 induced toxicity in SHSY5Y neuroblastoma cell lines and DRG neuronal cells. Read More

    Dietary reversal of neuropathy in a murine model of prediabetes and the metabolic syndrome.
    Dis Model Mech 2017 Apr 5. Epub 2017 Apr 5.
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Patients with the metabolic syndrome, defined as obesity, dyslipidemia, hypertension, and impaired glucose tolerance (IGT), can develop the same macro- and microvascular complications as patients with type 2 diabetes, including peripheral neuropathy. In type 2 diabetes, glycemic control has little effect on the development and progression of peripheral neuropathy, suggesting that other metabolic syndrome components may contribute to the presence of neuropathy. A parallel phenomenon is observed in patients with prediabetes and the metabolic syndrome, where improvement in weight and dyslipidemia more closely correlates with restoration of nerve function than improvement in glycemic status. Read More

    [Confocal microscope examination of the corneal nerve plexus as biomarker for systemic diseases : View from the corneal nerve plexus on diabetes mellitus disease].
    Ophthalmologe 2017 Apr 4. Epub 2017 Apr 4.
    Institut für Medizinische Biochemie und Molekularbiologie, Universitätsmedizin, Universität Rostock, Schillingallee 70, 18057, Rostock, Deutschland.
    It is estimated that approximately 50% of patients with diabetes mellitus suffer from polyneuropathy, which is frequently diagnosed too late. Consequently, the question arises whether imaging procedures of the eye, namely optical coherence tomography of the retina and confocal microscopy of the cornea are suitable for the diagnostics and follow-up control of neurodegenerative changes in patients with diabetes mellitus. De Clerck and co-workers could demonstrate this by a systematic review of studies. Read More

    Effect of tempol on peripheral neuropathy in diet-induced obese and high-fat fed/low-dose streptozotocin-treated C57Bl6/J mice.
    Free Radic Res 2017 Apr 19:1-8. Epub 2017 Apr 19.
    a Department of Internal Medicine , University of Iowa , Iowa City , IA , USA.
    In this study, we sought to determine the efficacy of tempol on multiple neuropathic endpoints in a diet-induced obese mouse, a model of pre-diabetes, and a high-fat fed low-dose streptozotocin treated mouse, a model of type 2 diabetes. Tempol (4-hydroxy-2,2,6,6-tetramethylpiperdine -1-oxyl) is a low molecular weight, water soluble, membrane permeable, and metal-independent superoxide dismutase mimetic that has been widely used in cellular studies for the removal of intracellular and extracellular superoxide. This in vivo study was designed to be an early intervention. Read More

    Neuropathic Pain.
    Continuum (Minneap Minn) 2017 Apr;23(2, Selected Topics in Outpatient Neurology):512-532
    Purpose Of Review: Neuropathic pain is a frequently encountered condition that is often resistant to treatment and is associated with poor patient satisfaction of their treatment. Several medications have been shown to be effective in treating neuropathic pain associated with diabetic neuropathy and postherpetic neuralgia, and these medications are often used to treat neuropathic pain associated with other conditions as well. This article summarizes the diagnosis and assessment of patients with neuropathic pain as well as available pharmacologic and interventional treatment options. Read More

    Cutaneous Manifestations of Diabetes Mellitus: A Review.
    Am J Clin Dermatol 2017 Apr 3. Epub 2017 Apr 3.
    Department of Dermatology, University Hospital Jena, Erfurter Straße 35, 07740, Jena, Germany.
    Diabetes mellitus is a widespread endocrine disease with severe impact on health systems worldwide. Increased serum glucose causes damage to a wide range of cell types, including endothelial cells, neurons, and renal cells, but also keratinocytes and fibroblasts. Skin disorders can be found in about one third of all people with diabetes and frequently occur before the diagnosis, thus playing an important role in the initial recognition of underlying disease. Read More

    Efficacy of Administration of an Angiotensin Converting Enzyme Inhibitor for Two Years on Autonomic and Peripheral Neuropathy in Patients with Diabetes Mellitus.
    J Diabetes Res 2017 8;2017:6719239. Epub 2017 Mar 8.
    Diabetes Center, First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.
    Aim. To evaluate the effect of quinapril on diabetic cardiovascular autonomic neuropathy (CAN) and peripheral neuropathy (DPN). Patients and Methods. Read More

    Neuroprotective effect of cerium oxide nanoparticles in a rat model of experimental diabetic neuropathy.
    Brain Res Bull 2017 Mar 31;131:117-122. Epub 2017 Mar 31.
    Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran; Tissue Engineering Group, (NOCERAL), Department of Orthopedics Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address:
    Objective: Neuropathies are a nerve disorders that caused by diabetes. Neuropathy affects over 50% of diabetic patients. High blood glucose and their toxic byproducts are the main causes for nerve dysfunction. Read More

    Effects of Danggui Sini decoction on neuropathic pain: experimental studies and clinical pharmacological significance of inhibiting glial activation and proinflammatory cytokines in the spinal cord
.
    Int J Clin Pharmacol Ther 2017 Apr 4. Epub 2017 Apr 4.
    Aim: Neuropathic pain responds poorly to drug treatments. Partial relief is achieved in only about half of the patients. Danggui Sini decoction (DSD), an aqueous extract of Angelica sinensis, Ramulus Cinnamomi, and Radix Puerariae, has been used extensively in China to treat inflammatory and ischemic diseases. Read More

    Efficacy of Mirogabalin (DS-5565) on Patient-Reported Pain and Sleep Interference in Patients with Diabetic Neuropathic Pain: Secondary Outcomes of a Phase II Proof-of-Concept Study.
    Pain Med 2017 Mar 23. Epub 2017 Mar 23.
    The Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia, USA.
    Objective. : To evaluate the effects of mirogabalin on patient-reported pain and sleep interference in diabetic peripheral neuropathic pain (DPNP).

    Subjects. Read More

    Isobolographic Analyses of Proglumide-Celecoxib Interaction in Rats with Painful Diabetic Neuropathy.
    Drug Dev Res 2017 Mar 3;78(2):116-123. Epub 2017 Apr 3.
    Division Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tabasco, México.
    Preclinical Research The aim of the present study was to analyze the antihyperalgesic and antiallodynic interaction between the non-selective cholecystokinin (CCK) antagonist receptor, proglumide, and the selective cyclooxygenase-2 inhibitor, celecoxib in streptozotocin (STZ)-induced diabetic rats. Hyperalgesia was evaluated in the formalin test and tactile allodynia using von Frey filaments. Isobolographic analyses were employed to define the nature of the compound interactions, using a fixed dose ratio (0. Read More

    The Effect of Glucose Variability on QTc Duration and Dispersion in Patients with Type 2 Diabetes Mellitus.
    Pak J Med Sci 2017 Jan-Feb;33(1):22-26
    Cihangir Uyan, MD. Professor, Department of Cardiology, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey.
    Objective: Glycemic variability (GV) is a new term with the episodes of hyper and hypoglycemia in diabetic patients. Both prolonged QT interval and QTd are potential risk factors for malignant ventricular arrhythmias affecting the mortality of different groups of patients including diabetes mellitus. In this study, we aimed to evaluate if the glucose variability increasing the QTc interval and QTc dispersion in type 2 diabetes mellitus. Read More

    Capsaicin 8% Patch Versus Oral Neuropathic Pain Medications for the Treatment of Painful Diabetic Peripheral Neuropathy: A Systematic Literature Review and Network Meta-Analysis.
    Clin Ther 2017 Mar 29. Epub 2017 Mar 29.
    Pharmerit International, Rotterdam, The Netherlands.
    Purpose: A network meta-analysis (NMA) was performed, aiming to assess the relative efficacy and tolerability of the capsaicin 179-mg (8% weight for weight) cutaneous patch (capsaicin 8% patch) compared with oral, centrally acting agents (ie, pregabalin, gabapentin, duloxetine, amitriptyline) in patients with painful diabetic peripheral neuropathy (PDPN).

    Methods: A systematic search of EMBASE/MEDLINE, Cochrane Library, and the National Health Service Centre for Reviews and Dissemination Database of Abstracts of Reviews of Effects was conducted to identify all randomized controlled trials. Data from eligible studies according to predefined inclusion and exclusion criteria were extracted, and analyses were based on aggregate-level data. Read More

    The period effect in the prevalence of proliferative diabetic retinopathy, gross proteinuria, and peripheral neuropathy in type 1 diabetes: A longitudinal cohort study.
    PLoS One 2017 31;12(3):e0174979. Epub 2017 Mar 31.
    Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America.
    Aims: To investigate whether, for a specific duration of type 1 diabetes, there is a significant change in the prevalence of proliferative diabetic retinopathy, gross proteinuria and peripheral neuropathy in those more recently diagnosed with diabetes (a period effect), in the Wisconsin Epidemiologic Study of Diabetic Retinopathy. Where present, to determine how common risk factors for diabetic complications might be associated with it, and what might be driving it.

    Materials And Methods: Longitudinal cohort study with seven examination phases between 1980 and 2014. Read More

    Antinociceptive Effect of Mirtazapine in Rats with Diabetic Neuropathy.
    Noro Psikiyatr Ars 2016 Mar 1;53(1):12-16. Epub 2016 Mar 1.
    Department of Pharmacology, Erciyes University School of Medicine, Kayseri, Turkey.
    Introduction: To evaluate the antinociceptive effect of mirtazapine and the mechanisms mediating this effect in neuropathic pain in rats with diabetes.

    Methods: The experiments were performed in Sprague Dawley rats using a hot-plate device. Streptozotocin (STZ) was administered to the rats after taking control measurements. Read More

    Effects of decompression on behavioral, electrophysiologic, and histomorphologic recovery in a chronic sciatic nerve compression model of streptozotocin-induced diabetic rats.
    J Pain Res 2017 20;10:643-652. Epub 2017 Mar 20.
    Department of Orthopedics, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
    Purpose: To determine susceptibility to decompression surgery in diabetic and nondiabetic peripheral neuropathy using a chronic compression neuropathy model.

    Materials And Methods: Twenty-four streptozotocin-induced diabetic rats were randomly divided into three groups: group I, chronic compression of the left sciatic nerve for 4 weeks with decompression; group II, similar without decompression; and group III, sham exposing the sciatic nerve only. The other 24 nondiabetic rats were assigned to groups IV-VI, which received compression-decompression, compression, and the sham operation, respectively. Read More

    Plantar fascia enthesopathy is highly prevalent in diabetic patients without peripheral neuropathy and correlates with retinopathy and impaired kidney function.
    PLoS One 2017 30;12(3):e0174529. Epub 2017 Mar 30.
    Department of Health Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy.
    Background: Aim of this study was to evaluate the prevalence of plantar fascia (PF) enthesopathy in Type 2 diabetes mellitus (T2DM) patients without distal peripheral neuropathy (DPN).

    Methods: We recruited 50 T2DM patients without DPN and 50 healthy controls. DPN was excluded using the Michigan Neuropathy Screening Instrument (MNSI). Read More

    Lack of Definite Association of Vitamin D Deficiency with Diabetic Neuropathy. Investigation in Greek and in Bangladeshi Patients.
    In Vivo 2017 Mar-Apr;31(2):259-261
    Department of Neurology, National and Kapodistrian University of Athens, Aeginition Hospital, Athens, Greece.
    Aim: Determination of the 25(OH) vitamin D levels in Greek-born and in Bangladeshi immigrant patients in Greece with diabetes with and without polyneuropathy.

    Materials And Methods: The method for the detection and staging of polyneuropathy proposed by Dyck, 1988 was used.

    Results: A total of 111 Bangladeshi immigrants and 101 Greek diabetic patients took part in the study. Read More

    Neurosteroids are reduced in diabetic neuropathy and may be associated with the development of neuropathic pain.
    F1000Res 2016 5;5:1923. Epub 2016 Aug 5.
    Department of Anaesthetics and Pain Management, Charing Cross Hospital, Imperial College NHS Healthcare Trust London, London, W6 8RF, UK.
    Introduction: Peripheral and central sensitisation are implicated in the development of neuropathic pain. Hypersensitivity of pain pathway neurons has been described in animal models of diabetic neuropathy, which is postulated to be related to an imbalance between inhibitory and excitatory signals within the spinal cord. GABAergic neurons within the pain pathway are vital for the transmission of painful stimuli to higher centres. Read More

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