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    Pulmonary function and sleep breathing: two new targets for type 2 diabetes care.
    Endocr Rev 2017 Sep 4. Epub 2017 Sep 4.
    Respiratory Department. Hospital Universitari Arnau de Vilanova-Santa María, IRB Lleida, Universitat de Lleida, Lleida, Catalonia, Spain.
    Population based studies showing the negative impact of type 2 diabetes (T2D) on lung function are overviewed. Among the well-recognized pathophysiological mechanisms, the metabolic pathways related to insulin resistance, low-grade chronic inflammation, leptin resistance, microvascular damage, and autonomic neuropathy are emphasized. Histopathological changes are exposed, and findings reported from experimental models are clearly differentiated from those described in humans. Read More

    Prevalence of diabetic foot ulceration and associated risk factors: an old and still major public health problem in Khartoum, Sudan?
    Ann Transl Med 2017 Sep;5(17):340
    Department of Medicine and HIV Metabolic Clinic, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire, UK.
    Background: Diabetic foot ulceration (DFU) is a major health problem across the globe. The objective of this study is to determine the prevalence of DFU and its associated risk factors in Sudanese individuals with diabetes.

    Methods: Three hundred and ten individuals with type 2 diabetes, who have been on treatment for DM for at least 1 year and volunteered to participate, were enrolled in this study. Read More

    Diabetes Mellitus as the Presenting Feature of Friedreich's Ataxia.
    J Neurosci Rural Pract 2017 Aug;8(Suppl 1):S117-S119
    Department of Pediatric Neurosciences, Bai Jerbai Wadia Hospital for Children, Mumbai, Maharashtra, India.
    Patients with Friedreich's ataxia (FA) are at an increased risk of developing diabetes mellitus and glucose intolerance. Diabetes usually develops many years after the initial presentation. We report an 8-year-old girl who initially presented with diabetic ketoacidosis and was treated as a case of insulin-dependent diabetes mellitus. Read More

    Current insight in the localized insulin-derived amyloidosis (LIDA): clinico-pathological characteristics and differential diagnosis.
    Pathol Res Pract 2017 Sep 1. Epub 2017 Sep 1.
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:
    Background: In diabetic patients, subcutaneous insulin injection may cause several types of injection site-related lesions, such as lipoatrophy, insulin-induced cutaneous lipohypertrophy (IICL), allergic reaction, and iatrogenic localized insulin-derived amyloidosis (LIDA). Among these complications, both IICL and LIDA present as tumor-like and slow growing lesions; and they may be confused with one another. The clinical implication and management of IICL and LIDA are different. Read More

    Conflicting interactions of apolipoprotein A and high density lipoprotein cholesterol with microvascular complications of type 2 diabetes.
    Diabetes Res Clin Pract 2017 Sep 1;133:131-141. Epub 2017 Sep 1.
    Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. Electronic address:
    Aims: This study is amid at investigating the associations, and interactions of serum lipid biomarkers with microvascular complications of type 2 diabetes (T2D).

    Methods: A nested case-control study was conducted within an ongoing prospective study on patients with T2D. Microvascular complications of T2D including diabetic neuropathy, diabetic retinopathy and diabetic nephropathy were investigated. Read More

    MG17, a novel triazole derivative abrogated neuroinflammation and related neurodegenerative symptoms in rodents.
    Curr Mol Pharmacol 2017 Sep 19. Epub 2017 Sep 19.
    Birla Institute of Technology & Science-Pilani, Hyderabad Campus. R.R. District-500078, Andhra Pradesh. India.
    The objective of present study is to explore multiple effects of the compound MG17 and relate them to achieve better therapeutic potential against neuroinflammation related disorders. We examined whether our compound is acting through regulating neuroinflammatory mediators. We have done some preliminary behavioral studies to shortlist the derivatives using rodent models of peripheral nerve injury in our earlier publication and now we extended our screening studies to explore the test compounds efficacy on other related peripheral neurological disorders such as Streptozotocin-induced diabetic peripheral neuropathy (DPN) and methyl mercury (MeHg) induced neurodegeneration in rats. Read More

    A new solvate of epalerstat, a drug for diabetic neuropathy.
    Acta Crystallogr E Crystallogr Commun 2017 Jul 28;73(Pt 8):1264-1267. Epub 2017 Jul 28.
    School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2-4-41, Ebara, Shinagawa, Tokyo 145-8501, Japan.
    Epalerstat {systematic name: (5Z)-5-[(2E)-2-methyl-3-phenyl-prop-2-en-1-yl-idene]-4-oxo-2-sulfanyl-idene-1,3-thia-zolidine-3-acetic acid} crystallized as an acetone monosolvate, C15H13NO3S2·C3H6O. In the epalerstat mol-ecule, the methyl-propyl-enediene moiety is inclined to the phenyl ring and the five-membered rhodamine ring by 21.4 (4) and 4. Read More

    Clinical evaluation of vasomotor system functionality in type 2 diabetic Patients.
    Caspian J Intern Med 2017 ;8(3):183-189
    Zanjan Applied Pharmacology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
    Background: Autonomic neuropathy and vital organ dysfunctions are the known complications in type 2 diabetes Mellitus (DM). Genetic endowments involving individuals make subtle differences in physiological systems, particularly at the time of sickness. Hence, the presented study was designed to evaluate the vasomotor system in healthy people and type 2 DM cases for determining any functionality differences between the mentioned groups. Read More

    Effects of whole-body vibration therapy on perception thresholds of type 2 diabetic patients with peripheral neuropathy: a randomized controlled trial.
    J Phys Ther Sci 2017 Sep 15;29(9):1684-1688. Epub 2017 Sep 15.
    Department of Physical Therapy, Kyungdong University: 815 Gyeonhwon-ro, Huyong-ri, Munmak-eup, Wonju-si, Gangwon-do 26495, Republic of Korea.
    [Purpose] The aim of this study was to investigate the effect of whole-body vibration training on perception thresholds in type 2 diabetic patients with peripheral neuropathy. [Subjects and Methods] Fifty-nine patients with diabetic neuropathy participated in the study. They were randomly divided into the experimental group (n=29) and the control group (n=30). Read More

    Growth factors in the pathogenesis of diabetic foot ulcers.
    Front Biosci (Landmark Ed) 2018 Jan 1;23:310-317. Epub 2018 Jan 1.
    Institute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, China.
    Foot ulcers affect 15% of patients with diabetes, resulting in a great health burden. The occurrence and development of diabetic foot ulcers is associated with neuropathy, peripheral arterial disease, and infection. Several growth factors are involved in these processes, including epidermal growth factor, vascular endothelial growth factor, transforming growth factor-beta, fibroblast growth factor, and erythropoietin, which could promote wound healing of patients with diabetes. Read More

    LncRNA NONRATT021972 Was Associated with Neuropathic Pain Scoring in Patients with Type 2 Diabetes.
    Behav Neurol 2017 8;2017:2941297. Epub 2017 Aug 8.
    Anesthesia Department, China-Japan Union Hospital of Jilin University, Changchun, China.
    Background: Long noncoding RNAs were involved in the processes of diabetes. Our study was aimed to explore clinical potential of LncRNA NONRATT021972 in diabetic neuropathic pain and investigate detailed mechanisms.

    Methods: 154 patients with type 2 diabetes were enrolled as experimental group paired with control. Read More

    Zebrafish as a Model for the Study of Microvascular Complications of Diabetes and Their Mechanisms.
    Int J Mol Sci 2017 Sep 19;18(9). Epub 2017 Sep 19.
    Department of Vascular Biology and Tumor Angiogenesis, Center for Biomedicine and Medical Technology Mannheim (CBTM), Medical Faculty Mannheim, Heidelberg University, D-68167 Mannheim, Germany.
    Diabetes mellitus (DM) is a crucial metabolic disease that leads to severe disorders. These include macrovascular complications such as myocardial infarction, stroke, and peripheral artery disease and microvascular complications including diabetic nephropathy, neuropathy, and retinopathy. Diabetes mellitus, along with its associated organ pathologies, is one of the key problems in today's medicine. Read More

    Effects of apelin peptides on diabetic complications.
    Curr Protein Pept Sci 2017 Sep 18. Epub 2017 Sep 18.
    School of Pharmacy Huazhong University of Science and Technology. China.
    Diabetes is a metabolic disorder with multiple complications, including cardiomyopathy, retinopathy, nephropathy and neuropathy. Diabetic complications are the major cause of disability and death in diabetic patients. Apelin, a recently identified adipokine peptide, has been found to play important roles in diabetic complications. Read More

    Morphine hyposensitivity in STZ-diabetic rats: Reversal by dietary L-arginine treatment.
    Clin Exp Pharmacol Physiol 2017 Sep 19. Epub 2017 Sep 19.
    School of Pharmacy, Faculty of Health and Behavioural Sciences, The University of Queensland, St Lucia Campus, Brisbane, Queensland, Australia, 4072.
    Painful diabetic neuropathy (PDN) is a long-term complication of diabetes. Defining symptoms include mechanical allodynia (pain due to light pressure or touch) and morphine hyposensitivity. In our previous work using the streptozotocin (STZ)-diabetic rat model of PDN, morphine hyposensitivity developed in a temporal manner with efficacy abolished at 3-months post-STZ and maintained for 6-months post-STZ. Read More

    CIDP and other inflammatory neuropathies in diabetes - diagnosis and management.
    Nat Rev Neurol 2017 Sep 15. Epub 2017 Sep 15.
    Weill Cornell Medicine-Qatar, Education City, PO Box 24144, Doha, Qatar.
    Distal symmetric polyneuropathy (DSPN) is the most common neuropathy to occur in diabetes mellitus. However, patients with diabetes can also develop inflammatory neuropathies, the most common and most treatable of which is chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Whether diabetes is a risk factor for CIDP remains under debate. Read More

    Patterns of cutaneous nerve fibre loss and regeneration in type 2 diabetes with painful and painless polyneuropathy.
    Diabetologia 2017 Sep 15. Epub 2017 Sep 15.
    Institute for Clinical Diabetology, German Diabetes Center (DDZ), Leibniz Center for Diabetes Research at Heinrich Heine University, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany.
    Aims/hypothesis: The determinants and mechanisms of the development of diabetic sensorimotor polyneuropathy as a painful (DSPN+p) or painless (DSPN-p) entity remain unclear. We examined the degree of cutaneous nerve fibre loss and regeneration in individuals with type 2 diabetes with DSPN+p or DSPN-p compared with individuals with recent-onset type 2 diabetes and corresponding healthy volunteers.

    Methods: In this cross-sectional study, skin biopsies taken from the distal lateral calf were obtained from individuals with recent-onset type 2 diabetes (n = 32) from the German Diabetes Study, with DSPN+p (n = 34) and DSPN-p (n = 32) from the PROPANE study, and volunteers with normal glucose tolerance (n = 50). Read More

    Diabetes and the Small Intestine.
    Curr Treat Options Gastroenterol 2017 Sep 15. Epub 2017 Sep 15.
    Temple University Digestive Disease Center, Temple University Hospital, Philadelphia, PA, USA.
    Opinion Statement: Diabetes mellitus (DM) and its associated complications are becoming increasingly prevalent. Gastrointestinal symptoms associated with diabetes is known as diabetic enteropathy (DE) and may manifest as either diarrhea, fecal incontinence, constipation, dyspepsia, nausea, and vomiting or a combination of symptoms. The long-held belief that vagal autonomic neuropathy is the primary cause of DE has recently been challenged by newer theories of disease development. Read More

    Diabetes and the Esophagus.
    Curr Treat Options Gastroenterol 2017 Sep 15. Epub 2017 Sep 15.
    School of Medicine Miguel Alemán Valdez, Veracruz, Veracruz, Mexico.
    Opinion Statement: Chronic hyperglycemia is a well-known cause of gastrointestinal motility disorders extending from the esophagus to the anorectum. Even though little attention has been paid to esophageal disorders in the context of DM, its prevalence is higher compared to gastroparesis. Heartburn, as a typical symptom of gastroesophageal reflux disease (GERD), is the most prevalent symptom and has been found in 25 to 41% of patients with DM. Read More

    Epidemiology of Peripheral Neuropathy: An Indian Perspective.
    Ann Indian Acad Neurol 2017 Jul-Sep;20(3):173-184
    Department Of Neurology, Bangur Institute Of Neurosciences, Kolkata, West Bengal, India.
    Peripheral neuropathy (PN) is a common disorder and presents as diagnostic and therapeutic challenge to physicians and neurologists. In epidemiological studies from India from various regions the overall prevalence of PN varied from 5 to 2400 per 10,000 population in various community studies. India is composed of a multiethnic, multicultural population who are exposed to different adverse environmental factors such as arsenic and lead. Read More

    Dyslipidemia impairs mitochondrial trafficking and function in sensory neurons.
    FASEB J 2017 Sep 13. Epub 2017 Sep 13.
    Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA;
    Mitochondrial trafficking plays a central role in dorsal root ganglion (DRG) neuronal cell survival and neurotransmission by transporting mitochondria from the neuronal cell body throughout the bundles of DRG axons. In type 2 diabetes (T2DM), dyslipidemia and hyperglycemia damage DRG neurons and induce mitochondrial dysfunction; however, the impact of free fatty acids and glucose on mitochondrial trafficking in DRG neurons remains unknown. To evaluate the impact of free fatty acids compared to hyperglycemia on mitochondrial transport, primary adult mouse DRG neuron cultures were treated with physiologic concentrations of palmitate and glucose and assessed for alterations in mitochondrial trafficking, mitochondrial membrane potential, and mitochondrial bioenergetics. Read More

    ASSOCIATIONS BETWEEN INDIVIDUAL RETINAL LAYER THICKNESSES AND DIABETIC PERIPHERAL NEUROPATHY USING RETINAL LAYER SEGMENTATION ANALYSIS.
    Retina 2017 Sep 7. Epub 2017 Sep 7.
    *Department of Ophthalmology, Institute of Vision Research, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; and†Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Purpose: To evaluate clinical correlations between the thicknesses of individual retinal layers in the foveal area of diabetic patients and the presence of diabetic peripheral neuropathy (DPN).

    Methods: This retrospective, observational, cross-sectional study enrolled a total of 120 eyes from 120 patients. The eyes were divided into 3 groups: normal controls (n = 42 eyes), patients with diabetes mellitus (n = 42 eyes) but no DPN, and patients with diabetes mellitus and DPN (n = 36 eyes). Read More

    Gene Expression Profiling Identifies Downregulation of the Neurotrophin-MAPK Signaling Pathway in Female Diabetic Peripheral Neuropathy Patients.
    J Diabetes Res 2017 16;2017:8103904. Epub 2017 Aug 16.
    Zhejiang Key Laboratory of Pathophysiology, Medical School of Ningbo University, Ningbo 315211, China.
    Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). It is not diagnosed or managed properly in the majority of patients because its pathogenesis remains controversial. In this study, human whole genome microarrays identified 2898 and 4493 differentially expressed genes (DEGs) in DM and DPN patients, respectively. Read More

    Protective Effects of Bogijetong Decoction and Its Selected Formula on Neuropathic Insults in Streptozotocin-Induced Diabetic Animals.
    Evid Based Complement Alternat Med 2017 16;2017:4296318. Epub 2017 Aug 16.
    Department of Oriental Medicine, Daejeon University, Daejeon 300-716, Republic of Korea.
    Bogijetong decoction (BGJTD) is a mixture of herbal formulation which is used in the traditional Korean medicine for the treatment of neuropathic pain caused by diabetes. Here, we investigated the regulatory effects of BGJTD and its reconstituted decoction subgroups on the neuropathic responses in streptozotocin- (STZ-) induced diabetic animals. Be decoction (BeD) was formulated by selecting individual herbal components that induced neurite outgrowth most efficiently in each subgroup. Read More

    MicroRNA-146a Mimics Reduce the Peripheral Neuropathy in Type II Diabetic Mice.
    Diabetes 2017 Sep 12. Epub 2017 Sep 12.
    Department of Neurology, Henry Ford Health System, Detroit, MI 48202.
    MicroRNA-146a (miR-146a) regulates multiple immune diseases. However, the role of miR-146a in diabetic peripheral neuropathy (DPN) has not been investigated. We found that mice (db/db) with type II diabetes exhibited substantial down-regulation of miR-146a in sciatic nerve tissue. Read More

    The Application of SUDOSCAN for Screening Diabetic Peripheral Neuropathy in Chinese Population Screening DPN by SUDOSCAN.
    Exp Clin Endocrinol Diabetes 2017 Sep 11. Epub 2017 Sep 11.
    Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School. No 321, Zhongshan Road, Nanjing, Jiangsu, 210008, China.
    Purpose Diabetic peripheral neuropathies are the common chronic complications of diabetes, but the diagnosis is insensitive by physical examination in busy outpatients. Here we evaluated the performance of SUDOSCAN in screening diabetic peripheral neuropathies in Chinese type 2 diabetic patients. Methods The study enrolled 180 patients for annually screening. Read More

    The association between pulse wave velocity and peripheral neuropathy in patients with type 2 diabetes mellitus.
    J Diabetes Complications 2017 Jul 27. Epub 2017 Jul 27.
    Diabetes Center, First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece. Electronic address:
    Aims: Diabetic peripheral neuropathy (DPN) is the most common diabetic complication, affecting up to half of the patients with type 2 diabetes mellitus (T2DM). Increased aortic stiffness, measured with the carotid-femoral pulse wave velocity (PWV), has been associated with incidence of cardiovascular disease independently of traditional risk factors. Previous data showed associations between risk factors for macroangiopathy and DPN in diabetes. Read More

    Fish oil emulsion supplementation might improve quality of life of diabetic patients due to its antioxidant and anti-inflammatory properties.
    Nutr Res 2017 Aug 3. Epub 2017 Aug 3.
    Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Sasinkova 2, 813 72 Bratislava, Slovakia. Electronic address:
    Diabetes-related complications, including cardiovascular disease, retinopathy, nephropathy, and neuropathy, are a significant cause of increased morbidity and mortality among people with diabetes. Previous studies have confirmed that hyperglycemia has pro-oxidative and proinflammatory properties which cause diabetic complications. We hypothesized that supplementation of fish oil emulsion (FOE), rich in omega-3 polyunsaturated fatty acids, to diabetic patients might reduce hyperglycemia-induced pathological changes due to specific properties of FOE. Read More

    Trial design and rationale for APOLLO, a Phase 3, placebo-controlled study of patisiran in patients with hereditary ATTR amyloidosis with polyneuropathy.
    BMC Neurol 2017 Sep 11;17(1):181. Epub 2017 Sep 11.
    Hospital Santo António, Centro Hospitalar do Porto, Porto, Portugal.
    Background: Patisiran is an investigational RNA interference (RNAi) therapeutic in development for the treatment of hereditary ATTR (hATTR) amyloidosis, a progressive disease associated with significant disability, morbidity, and mortality.

    Methods: Here we describe the rationale and design of the Phase 3 APOLLO study, a randomized, double-blind, placebo-controlled, global study to evaluate the efficacy and safety of patisiran in patients with hATTR amyloidosis with polyneuropathy. Eligible patients are 18-85 years old with hATTR amyloidosis, investigator-estimated survival of ≥2 years, Neuropathy Impairment Score (NIS) of 5-130, and polyneuropathy disability score ≤IIIb. Read More

    Comparison of Somatic and Sudomotor Nerve Fibers in Type 2 Diabetes Mellitus.
    J Clin Neurol 2017 Sep 4. Epub 2017 Sep 4.
    Department of Neurology, Chungnam University Hospital, Daejeon, Korea.
    Background And Purpose: The objective of this study was to find a sensitive method for the early detection of diabetic polyneuropathy (DPN) and determine the relationship between the functions of somatic and autonomic small nerve fibers in DPN.

    Methods: Patients with type 2 diabetes mellitus and DPN based on clinical symptoms, signs, intraepidermal nerve fiber density (IENFD), and findings in the quantitative sudomotor axon reflex test (QSART) were enrolled retrospectively. Neurological examinations and nerve conduction studies were performed on all patients. Read More

    An observational study of vitamin b12 levels and peripheral neuropathy profile in patients of diabetes mellitus on metformin therapy.
    Diabetes Metab Syndr 2017 Aug 25. Epub 2017 Aug 25.
    Department of Medicine, Lady Hardinge Medical College, Shaheed Bhagat Singh Road, Diz Area, Connaught Place, New Delhi, 110001, India. Electronic address:
    Methods: A descriptive, observational study was completed in a tertiary care hospital between November 2014 and March 2016. Fifty consecutive patients of Type 2-Diabetes Mellitus who had been on metformin therapy for at least three months were included in our study. Several Parameters were compared with vitamin B12 levels and severity of peripheral neuropathy (using Toronto Clinical Scoring System (TCSS) and Nerve Conduction Velocity). Read More

    Comparison of electrochemical skin conductance and vibration perception threshold measurement in the detection of early diabetic neuropathy.
    PLoS One 2017 7;12(9):e0183973. Epub 2017 Sep 7.
    Department of Endocrinology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India.
    The early diagnosis of diabetic peripheral neuropathy (DPN) is challenging. Sudomotor dysfunction is one of the earliest detectable abnormalities in DPN. The present study aimed to determine the diagnostic performance of the electrochemical skin conductance (ESC) test in detecting early DPN, compared with the vibration perception threshold (VPT) test and diabetic neuropathy symptom (DNS) score, using the modified neuropathy disability score (NDS) as the reference standard. Read More

    NMDAR antagonists for the treatment of diabetes mellitus-Current status and future directions.
    Diabetes Obes Metab 2017 Sep;19 Suppl 1:95-106
    Institute of Metabolic Physiology, Department of Biology, Heinrich Heine University, Düsseldorf, Germany.
    Diabetes mellitus is characterized by chronically elevated blood glucose levels accelerated by a progressive decline of insulin-producing β-cells in the pancreatic islets. Although medications are available to transiently adjust blood glucose to normal levels, the effects of current drugs are limited when it comes to preservation of a critical mass of functional β-cells to sustainably maintain normoglycemia. In this review, we recapitulate recent evidence on the role of pancreatic N-methyl-D-aspartate receptors (NMDARs) in β-cell physiology, and summarize effects of morphinan-based NMDAR antagonists that are beneficial for insulin secretion, glucose tolerance and islet cell survival. Read More

    Effects of S 38093, an antagonist/inverse agonist of histamine H3 receptors, in models of neuropathic pain in rats.
    Eur J Pain 2017 Sep 6. Epub 2017 Sep 6.
    Institut de Recherches Internationales Servier (I.R.I.S.), Suresnes Cedex, France.
    Background: Histamine H3 receptors are mainly expressed on CNS neurons, particularly along the nociceptive pathways. The potential involvement of these receptors in pain processing has been suggested using H3 receptor inverse agonists.

    Methods: The antinociceptive effect of S 38093, a novel inverse agonist of H3 receptors, has been evaluated in several neuropathic pain models in rat and compared with those of gabapentin and pregabalin. Read More

    Spinal Cord Stimulator Explantation: Motives for Removal of Surgically Placed Paddle Systems.
    Pain Pract 2017 Sep 5. Epub 2017 Sep 5.
    Allegheny General Hospital, Department of Neurosurgery Pittsburgh, PA, 420 East North Avenue, Pittsburgh, Pennsylvania, 15212, USA.
    Background: Despite requiring successful trials prior to implantation, spinal cord stimulation (SCS) systems for pain are often later removed. Removing surgically implanted hardware subjects patients to the risks and discomfort of a second surgery, threatens the cost-effectiveness of SCS, and limits the perceived durability of SCS technology for pain problems.

    Objective: To investigate patterns of reasons given among patients who underwent SCS explant surgery (SCSES). Read More

    Altered Semmes-Weinstein monofilament test results are associated with oxidative stress markers in type 2 diabetic subjects.
    J Transl Med 2017 Sep 6;15(1):187. Epub 2017 Sep 6.
    Service of Endocrinology and Nutrition, Hospital Clínico Universitario de Valencia, Avda Blasco Ibañez, 17, 46010, Valencia, Spain.
    Background: Different lines of evidence suggest that oxidative stress (OS) is implicated in the pathogenesis of diabetic neuropathy. The Semmes-Weinstein monofilament (SWM) test is an efficient tool for evaluating diabetic polyneuropathy and diabetic foot. In this study, we analyzed the association between OS markers and altered SWM test results in type 2 diabetes (T2DM) patients. Read More

    Intraoperative magnesium sulphate decreases agitation and pain in patients undergoing functional endoscopic surgery: A randomised double-blind study.
    Eur J Anaesthesiol 2017 Oct;34(10):658-664
    From the Faculty of Medicine, Menoufia University, Shibin El Kom, Menofia (HEE); Faculty of Medicine, Ain Shams University, Cairo (MCM); Faculty of Medicine, Menoufia University, Shibin El Kom (HAA); and Faculty of Medicine Al-Azhar University, Cairo, Egypt (AAH).
    Background: Postoperative agitation is harmful for the patient as it may be associated with removal of catheters, nasal packs, oxygen masks and self-injury, and pose a danger to operating theatre staff.

    Objective: The current study investigated the potential role of magnesium sulphate in treatment of postoperative agitation following functional endoscopic sinus surgery.

    Design: A randomised, double-blinded, placebo-controlled trial. Read More

    Weak bones in diabetes mellitus - an update on pharmaceutical treatment options.
    J Pharm Pharmacol 2017 Sep 5. Epub 2017 Sep 5.
    School of Pharmacy, Curtin University, Bentley, WA 6102, Australia.
    Objectives: Diabetes mellitus is often associated with a number of complications such as nephropathy, neuropathy, retinopathy and foot ulcers. However, weak bone is a diabetic complication that is often overlooked. Although the exact mechanism for weak bones within diabetes mellitus is unclear, studies have shown that the mechanism does differ in both type I (T1DM) and type II diabetes (T2DM). Read More

    Importance of education in the prevention of diabetic foot syndrome.
    Neuro Endocrinol Lett 2017 Aug 5;38(4):255-256. Epub 2017 Aug 5.
    Faculty of Health and Social Studies, South Bohemian University, Ceske Budejovice, Czech Republic.
    To the Editor, Diabetic foot syndrome (DFS) is defined by the WHO as ulceration or destruction of foot tissue in diabetic patients associated with neuropathy, with different degrees of the disease existing and frequently also with infection. The statistics are frightening: more than million amputations are annually carried out worldwide due to diabetic foot (Foster and Lauver 2014) and these amputations represent as far as 70% of all non-traumatic amputations. In 2013, 861 647 patients were treated for diabetes mellitus in Czech Republic, including 44 657 patients with diabetic foot syndrome and 11 168 patients had to experience the amputation of lower limb due to this condition. Read More

    Repeated transcranial direct current stimulation improves cognitive dysfunction and synaptic plasticity deficit in the prefrontal cortex of streptozotocin-induced diabetic rats.
    Brain Stimul 2017 Aug 24. Epub 2017 Aug 24.
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:
    Background: Cognitive dysfunction is commonly observed in diabetic patients. We have previously reported that anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex can facilitate visuospatial working memory in diabetic patients with concomitant diabetic peripheral neuropathy and mild cognitive impairment, but the underlying mechanisms remain unclear.

    Objective: We investigated the cellular mechanisms underlying the effect of tDCS on cognitive decline in streptozotocin (STZ)-induced diabetic rats. Read More

    Effects of High-Dose α-Lipoic Acid on Heart Rate Variability of Type 2 Diabetes Mellitus Patients with Cardiac Autonomic Neuropathy in Korea.
    Diabetes Metab J 2017 Aug;41(4):275-283
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    Background: Diabetic cardiac autonomic neuropathy (CAN) is one of the important complications of diabetes. It is characterized by reduced heart rate variability (HRV).

    Methods: In this randomized, double-blind, placebo-controlled, multicenter trial, 75 patients were randomly assigned to one of two groups. Read More

    Grip force control and hand dexterity are impaired in individuals with diabetic peripheral neuropathy.
    Neurosci Lett 2017 Sep 1;659:54-59. Epub 2017 Sep 1.
    Institute of Physical Activity and Sports Sciences and Interdisciplinary Graduate Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil. Electronic address:
    Diabetic peripheral neuropathy (DPN) affects the sensory function of the hands and, consequently, may negatively impact hand dexterity, maximum grip strength (GSMax), and hand grip force (GF) control during object manipulation. The aims of this study were to examine and compare the GF control during a simple holding task as well as GSMax and hand dexterity of individuals with DPN and healthy controls. Ten type 2 diabetic individuals diagnosed with DPN and ten age- and gender-matched healthy controls performed two traditional timed hand dexterity tests (i. Read More

    Clinical and microbiological profile of diabetic foot ulcer patients in a tertiary care hospital.
    Diabetes Metab Syndr 2017 Aug 26. Epub 2017 Aug 26.
    Department of Medicine, Yenepoya University, Deralakatte, Mangalore, India. Electronic address:
    Aim: To evaluate the clinical and microbiological profile of diabetic foot ulcer patients admitted to a tertiary care hospital.

    Methodology: This study recruited 120 diabetic foot ulcer patients of all grade. Their medical records were evaluated retrospectively. Read More

    Clinical measures of balance in people with type two diabetes: A systematic literature review.
    Gait Posture 2017 Aug 24;58:325-332. Epub 2017 Aug 24.
    Physiotherapy Department, School of Clinical Sciences, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand. Electronic address:
    Approximately 422 million people have diabetes mellitus worldwide, with the majority diagnosed with type 2 diabetes mellitus (T2DM). The complications of diabetes mellitus include diabetic peripheral neuropathy (DPN) and retinopathy, both of which can lead to balance impairments. Balance assessment is therefore an integral component of the clinical assessment of a person with T2DM. Read More

    Diabetic Neuropathy and Gait: A Review.
    Diabetes Ther 2017 Sep 1. Epub 2017 Sep 1.
    Division of Diabetes, Endocrinology and Gastroenterology, Institute of Human Development, University of Manchester and the Manchester Royal Infirmary, Central Manchester Hospital Foundation Trust, Manchester, UK.
    Diabetic peripheral neuropathy (DPN) is a major sequela of diabetes mellitus and may have a detrimental effect on the gait of people with this complication. DPN causes a disruption in the body's sensorimotor system and is believed to affect up to 50% of patients with diabetes mellitus, dependent on the duration of diabetes. It has a major effect on morbidity and mortality. Read More

    Functional recovery upon human dental pulp stem cell transplantation in a diabetic neuropathy rat model.
    Cytotherapy 2017 Oct 30;19(10):1208-1224. Epub 2017 Aug 30.
    School of Regenerative Medicine, Manipal University, Bengaluru, Karnataka, India.
    Diabetic neuropathy (DN) is among the most debilitating complications of diabetes. Here, we investigated the effects of human dental pulp stem cell (DPSC) transplantation in Streptozotocin (STZ)-induced neuropathic rats. Six weeks after STZ injection, DPSCs were transplanted through two routes, intravenous (IV) or intramuscular (IM), in single or two repeat doses. Read More

    Combination of quercetin, cinnamaldehyde and hirudin protects rat dorsal root ganglion neurons against high glucose-induced injury through Nrf-2/HO-1 activation and NF-κB inhibition.
    Chin J Integr Med 2017 Sep 2;23(9):663-671. Epub 2017 Sep 2.
    Department of Traditional Chinese Medicine, Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
    Objective: To examine the effects of the combination of quercetin (Q), cinnamaldehyde (C) and hirudin (H), a Chinese medicine formula on high glucose (HG)-induced apoptosis of cultured dorsal root ganglion (DRG) neurons.

    Methods: DRG neurons exposed to HG (45 mmol/L) for 24 h were employed as an in vitro model of diabetic neuropathy. Cell viability, reactive oxygen species (ROS) level and apoptosis were determined. Read More

    Diabetic Neuropathy Evaluated by a Novel Device: Sural Nerve Conduction Is Associated with Glycemic Control and Ankle-Brachial Pressure Index in Japanese Patients with Diabetes.
    Front Endocrinol (Lausanne) 2017 15;8:203. Epub 2017 Aug 15.
    Hamasaki Clinic, Kagoshima, Japan.
    Background: Currently, no international diagnostic criteria for diabetic neuropathy (DN) have been established. Recently, a novel point-of-care sural nerve conduction device has been developed. We aimed to investigate associations between DN and clinical parameters related to the development and progression of DN by using this novel device. Read More

    Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study.
    Pain 2017 Aug 3. Epub 2017 Aug 3.
    aCentral European Institute of Technology, Masaryk University, Brno, Czech Republic bDepartment of Neurology, University Hospital Brno, Brno, Czech Republic cDepartment of Neurology, University of Würzburg, Würzburg, Germany dDepartment of Neurology, University Medical Center, Mainz, Germany eDepartment of Anesthesiology, Centre for Interdisciplinary Pain Medicine, University Hospital Würzburg, Würzburg, Germany fDivision of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria gDiabetologic Centre, Department of Internal Medicine and Gastroenterology, University Hospital Brno, Brno, Czech Republic hDiabetologic Centre, St. Anne University Hospital, Brno, Czech Republic iDepartment of Internal Medicine, Geriatrics and Practical Medicine, University Hospital Brno, Brno, Czech Republic jInstitute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
    Different sensory profiles in diabetic distal symmetrical sensory-motor polyneuropathy (DSPN) may be associated with pain and the responsiveness to analgesia. We aimed to characterize sensory phenotypes of patients with painful and painless diabetic neuropathy and to assess demographic, clinical, metabolic, and electrophysiological parameters related to the presence of neuropathic pain in a large cohort of well-defined DSPN subjects. This observational cross-sectional multi-center cohort study (performed as part of the ncRNAPain EU consortium) of 232 subjects with nonpainful (n = 74) and painful (n = 158) DSPN associated with diabetes mellitus of type 1 and 2 (median age 63 years, range 21-87 years; 92 women) comprised detailed history taking, laboratory tests, neurological examination, quantitative sensory testing, nerve conduction studies, and neuropathy severity scores. Read More

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