27,793 results match your criteria Diabetic Neuropathy


Can a combination of lifestyle and clinical characteristics explain the presence of foot ulcer in patients with diabetes?

J Diabetes Complications 2019 Mar 1. Epub 2019 Mar 1.

Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Abbas Medical Centre, Dar es Salaam, Tanzania.

Aims: The aim of this study was to identify the biomechanical, neurological and clinical parameters along with other demographics and lifestyle risk factors that could explain the presence of foot ulcer in patients with diabetes in Africa.

Methods: A total of 1270 (M/F:696/574) patients; 77(M/F:53/24) with ulcerated vs 1193 (M/F: 643/550) with non-ulcerated feet; participated in this study. A set of 28 parameters were collected and compared between the participants with and without active foot ulcers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183067
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http://dx.doi.org/10.1016/j.jdiacomp.2019.02.006DOI Listing
March 2019
1 Read

Standard complication screening information can be used for risk assessment for first time foot ulcer among patients with type 1 and type 2 diabetes.

Diabetes Res Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Steno Diabetes Center Copenhagen, Niels Steensensvej 2, 2820 Gentofte, Denmark; Department of Dermatology and Copenhagen Woundhealing Center, Copenhagen Wound Healing Center, Copenhagen University Hospital Bispebjerg, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark.

Aim: Diabetic foot ulcer (DFU) is a major complication of both Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D); however research into risk factors for DFU does not separate between these two types. The purpose of the present investigation was to identify risk factors for development of first time DFU (FTDFU) over a period of 15 years in patients with T1D and T2D separately.

Methods: This retrospective cohort study included 25220 feet from 5588 patients with T1D and 7113 patients with T2D treated in the period 2001 to 2015. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183172
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http://dx.doi.org/10.1016/j.diabres.2019.04.021DOI Listing
April 2019
1 Read

Effect of Gua Sha therapy on patients with diabetic peripheral neuropathy: A randomized controlled trial.

Complement Ther Clin Pract 2019 May 25;35:348-352. Epub 2019 Mar 25.

Research Institute of Gynecology and Obstetrics, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address:

Objective: To examine the effect of Gua Sha therapy in the treatment of diabetic peripheral neuropathy (DNP).

Design: An open-label randomized controlled study was conducted with usual care as the control (60 subjects in Gua Sha group and 59 subjects in usual care group). Outcome measures included Toronto Clinical Scoring System (TCSS), Vibration Perception Threshold (VPT), Ankle Brachial Index (ABI), and fasting plasma glucose (FPG). Read More

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http://dx.doi.org/10.1016/j.ctcp.2019.03.018DOI Listing

Calcaneal tuberosity fractures through prior Schantz pin sites in patients with diabetic neuropathy.

Foot (Edinb) 2019 Mar 2;39:96-99. Epub 2019 Mar 2.

Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, United States.

Schantz pin placement in the calcaneal tuberosity is a common procedure known to be complicated by pin site infections and nerve injuries. Fractures through Schantz pin sites has been reported mostly in diaphyseal bone. This case series highlights three patients with type 2 diabetes mellitus and diabetic neuropathy who were fixed in an external fixator frame with a pin through the calcaneal tuberosity. Read More

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http://dx.doi.org/10.1016/j.foot.2019.02.011DOI Listing

Activation of K7 channels with the anticonvulsant retigabine alleviates neuropathic pain behaviour in the streptozotocin rat model of diabetic neuropathy.

J Drug Target 2019 Apr 17:1-25. Epub 2019 Apr 17.

b Medical Physics & Biomedical Engineering, University College London , Gower, Street , London , UK.

Diabetic peripheral neuropathy (DPN) is the most incapacitating complication of diabetes mellitus. Up to 50% of patients with DPN develop peripheral neuropathic pain (PNP). The underlying ionic and molecular mechanisms of diabetic PNP (DPNP) are poorly understood. Read More

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http://dx.doi.org/10.1080/1061186X.2019.1608552DOI Listing
April 2019
1 Read

Effects of Aerobic Exercise on Vibration Perception Threshold in Type 2 Diabetic Peripheral Neuropathy Population Using 3-sites Method: Single-blind Randomized Controlled Trial.

Altern Ther Health Med 2019 Mar;25(2):36-41

Objectivest: The purpose of this study was to examine the effects of 8 wk of moderate intensity aerobic exercise on vibration perception threshold (VPT) in type 2 diabetic peripheral neuropathy (DPN).

Methods: Single blind parallel group randomized controlled trial was done in a tertiary center. Stratified block randomization was used for selecting participants. Read More

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March 2019
2 Reads

The combined effect of mesenchymal stem cells and resveratrol on type 1 diabetic neuropathy.

Exp Ther Med 2019 May 13;17(5):3555-3563. Epub 2019 Mar 13.

Endocrinology Department, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.

Diabetic neuropathy (DN) is one of the most common diabetic complications that results in an increase in patient discomfort and pain. The present study demonstrated that mesenchymal stem cells (MSCs) or resveratrol (RSV) may improve diabetic hyperglycemia and neuropathy. The aim of the present study was to investigate the combined effect of MSCs and RSV on DN. Read More

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http://www.spandidos-publications.com/10.3892/etm.2019.7383
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http://dx.doi.org/10.3892/etm.2019.7383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447822PMC
May 2019
2 Reads

Hyperglycaemia-Induced Downregulation in Expression of nNOS Intramural Neurons of the Small Intestine in the Pig.

Int J Mol Sci 2019 Apr 4;20(7). Epub 2019 Apr 4.

Department of Clinical Physiology Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego Str. 13, 10-719 Olsztyn, Poland.

Diabetic autonomic peripheral neuropathy (PN) involves a broad spectrum of organs. One of them is the gastrointestinal (GI) tract. The molecular mechanisms underlying the pathogenesis of digestive complications are not yet fully understood. Read More

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http://dx.doi.org/10.3390/ijms20071681DOI Listing
April 2019
2 Reads

Jinmaitong, a Traditional Chinese Compound Prescription, Ameliorates the Streptozocin-Induced Diabetic Peripheral Neuropathy Rats by Increasing Sciatic Nerve IGF-1 and IGF-1R Expression.

Front Pharmacol 2019 29;10:255. Epub 2019 Mar 29.

Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China.

Jinmaitong (JMT) is a Traditional Chinese Compound Prescription for the treatment of diabetic peripheral neuropathy (DPN). This study aims to investigate the effect of JMT on the insulin-like growth factor 1 (IGF-1) and the insulin like growth factor 1 receptor (IGF-1R) expression in sciatic nerves of diabetic rats. Firstly, the chemical profile of JMT was characterized by UPLC/Q-TOF-MS analysis. Read More

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http://dx.doi.org/10.3389/fphar.2019.00255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450141PMC
March 2019
1 Read

Evaluation of various risk factors associated with multidrug-resistant organisms isolated from diabetic foot ulcer patients.

J Lab Physicians 2019 Jan-Mar;11(1):58-62

Department of Surgery, Government Medical College and Hospital, Chandigarh, India.

Aims: Diabetic foot ulcer is a dreaded complication of diabetes. Diabetic foot ulcer patients are often infected with multidrug resistant organism (MDRO) due to chronic course of the wound, inappropriate antibiotics treatment, frequent hospital admission, neuropathy, nephropathy, and peripheral vascular disease.

Materials And Methods: This prospective study was conducted in our 750 bedded hospital for a period of 6 months. Read More

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http://www.jlponline.org/text.asp?2019/11/1/58/254072
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http://dx.doi.org/10.4103/JLP.JLP_106_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437817PMC
April 2019
2 Reads

Psychosocial Factors in Painful Diabetic Neuropathy: A Systematic Review of Treatment Trials and Survey Studies.

Pain Med 2019 Apr 13. Epub 2019 Apr 13.

Health Psychology Section, Psychology Department, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK.

Objective: Diabetes mellitus is associated with a number of complications that can adversely impact patients' quality of life. A common and often painful complication is painful diabetic neuropathy. The aims of this study were to systematically review and summarize evidence from studies of psychological treatments and psychosocial factors related to painful diabetic neuropathy and assess the methodological quality of these studies. Read More

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http://dx.doi.org/10.1093/pm/pnz071DOI Listing
April 2019
1 Read

[Diagnosis, treatment and monitoring of diabetic eye disease (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Universitäts-Augenklinik, Medizinische Universität Graz, Graz, Österreich.

Diabetes mellitus can cause diabetic retinopathy, diabetic macular edema, optic neuropathy, cataract or dysfunction of the eye muscles. The incidence of these defects correlates with disease duration and quality of metabolic control. Recommendations of the Austrian Diabetes Association for diagnosis, therapeutic procedures and requirements for adequate follow-up depending on stage of diabetic eye disease are summarized. Read More

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http://dx.doi.org/10.1007/s00508-019-1445-1DOI Listing
April 2019
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[Diabetic neuropathy and diabetic foot syndrome (Update 2019)].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Universitätsklinik für Innere Medizin, Medizinische Universität Graz, Graz, Österreich.

These are the guidelines for diagnosis and treatment of diabetic neuropathy and diabetic foot. Diabetic neuropathy comprises a number of mono- and polyneuropathies, plexopathies, radiculopathies and autonomic neuropathy.The position statement summarizes characteristic clinical symptoms and techniques for diagnostic assessment of diabetic neuropathy, including the complex situation of the diabetic foot syndrome. Read More

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http://link.springer.com/10.1007/s00508-019-1487-4
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http://dx.doi.org/10.1007/s00508-019-1487-4DOI Listing
April 2019
3 Reads

Quantitative assessment of diabetic amyotrophy using magnetic resonance neurography-a case-control analysis.

Eur Radiol 2019 Apr 12. Epub 2019 Apr 12.

UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390-9178, USA.

Objectives: To quantitatively characterize diabetic amyotrophy (DA), or diabetic lumbosacral radiculoplexopathy, and compare with controls using magnetic resonance neurography (MRN).

Methods: Forty controls and 23 DA cases were analyzed qualitatively and quantitatively. Cross-sectional areas (CSAs) of bilateral L3 through S2 lumbosacral nerve roots, femoral nerves, and sciatic nerves (proximal and distal measurements) were measured. Read More

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http://link.springer.com/10.1007/s00330-019-06162-3
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http://dx.doi.org/10.1007/s00330-019-06162-3DOI Listing
April 2019
3 Reads

Diabetic foot infections: a comprehensive overview.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):26-37

Diabetes Care Unit, Endocrinology, University Hospital "A. Gemelli", Catholic University of the Sacred Heart, Rome, Italy.

Diabetic foot ulcers (DFUs), a micro-vascular complication, are associated with a substantial increase in morbidity and mortality. DFUs are a complicated mixture of neuropathy, peripheral arterial diseases, foot deformities, and infections. Foot infections are frequent and potentially devastating complications. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17471DOI Listing
April 2019
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Shear wave elastography evaluation of the median and tibial nerve in diabetic peripheral neuropathy.

Quant Imaging Med Surg 2019 Feb;9(2):273-282

Department of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, China.

Background: To evaluate the value of shear wave elastography (SWE) in the detection of diabetic peripheral neuropathy (DPN) of the median and tibial nerves.

Methods: The study included 40 DPN patients, 40 diabetic mellitus (DM) patients without DPN, and 40 healthy subjects. High-resolution ultrasonography (US) and SWE were performed on the median nerve (MN) and tibial nerve (TN), and cross-sectional area (CSA) and nerve stiffness were measured. Read More

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http://dx.doi.org/10.21037/qims.2019.02.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414758PMC
February 2019
1 Read

Gender differences in attitudes and attributes of people using therapeutic shoes for diabetic foot complications.

J Foot Ankle Res 2019 29;12:21. Epub 2019 Mar 29.

2University Health Care Research Center, Faculty of Medicine and Health, Örebro University, SE 70182 Örebro, Sweden.

Background: Therapeutic shoes can prevent diabetic foot reulcerations but their use is complicated by the fact that shoes have psychological and social meanings, which is believed to put a larger burden on women than men. The aim was to compare attitudes and attributes of women and men using therapeutic shoes for diabetic foot complications.

Methods: A questionnaire was posted to 1230 people with diabetes who had been fitted with therapeutic shoes. Read More

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http://dx.doi.org/10.1186/s13047-019-0327-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440011PMC
March 2019
1 Read

A rare case of a gabapentin-induced cardiomyopathy.

J Clin Pharm Ther 2019 Apr 9. Epub 2019 Apr 9.

BJC Medical Group Cardiology, St. Louis, Missouri.

What Is Known And Objective: Gabapentin, a γ-aminobutyric acid derivative, is used for the treatment of partial onset seizures, postherpetic neuralgia, diabetic neuropathy and a host of other neurological disorders.

Case Description: A 44-year-old woman with spinal stenosis was prescribed gabapentin for pain. Two months after initiating therapy, she was diagnosed with a new-onset non-ischaemic cardiomyopathy with an ejection fraction of 36% measured on a transthoracic echocardiogram. Read More

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http://dx.doi.org/10.1111/jcpt.12840DOI Listing
April 2019
2 Reads

Current concepts in curative surgery for diabetic forefoot ulcers.

Foot (Edinb) 2019 Feb 2;39:37-44. Epub 2019 Feb 2.

Department of Plastic and Orthopedic Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United States.

Forefoot ulcerations in patients with diabetes are quite common. Underlying mechanical deformities of the foot in combination with neuropathy are the most important risk factors for ulcer development and adequate offloading is the mainstay of management. Most ulcers heal with local wound care, adequate blood supply, and pressure relief. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09582592183020
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http://dx.doi.org/10.1016/j.foot.2019.01.010DOI Listing
February 2019
3 Reads

The efficacy of pregabalin for the treatment of neuropathic pain in Japanese subjects with moderate or severe baseline pain.

J Pain Res 2019 22;12:1061-1068. Epub 2019 Mar 22.

Global Statistics, Pfizer Inc, New York, NY, USA.

Purpose: Although analyses of pooled clinical trial data have reported how international populations respond to pregabalin by baseline neuropathic pain (NeP) severity, no studies have evaluated this specifically in patients from Japan. Thus, this post hoc pooled analysis evaluated the efficacy of pregabalin in Japanese subjects for treating moderate or severe baseline NeP.

Patients And Methods: Data were pooled from three placebo-controlled trials enrolling Japanese subjects with postherpetic neuralgia (PHN), diabetic peripheral neuropathy (DPN), and spinal cord injury (SCI). Read More

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http://dx.doi.org/10.2147/JPR.S181729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434920PMC
March 2019
1 Read

Painful Diabetic Peripheral Neuropathy Study of Chinese OutPatiEnts (PDN-SCOPE): protocol for a multicentre cross-sectional registry study of clinical characteristics and treatment in China.

BMJ Open 2019 Apr 8;9(4):e025722. Epub 2019 Apr 8.

Neurology, Peking University Third Hospital, Beijing, China.

Introduction: Painful diabetic peripheral neuropathy (PDN) is a growing public health problem in China. Despite recent progress in treatment, there has been no nationwide study evaluating current medical practices and compliance with treatment guidelines. The primary aims of this study are to investigate the clinical characteristics and treatment practices for PDN and associated anxiety and depression in China. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025722DOI Listing
April 2019
2 Reads

Effects of mirogabalin, a novel ligand for the α₂δ subunit of voltage-gated calcium channels, on N-type calcium channel currents of rat dorsal root ganglion culture neurons.

Pharmazie 2019 Mar;74(3):147-149

Mirogabalin, which is a novel ligand for the α₂δ subunit of voltage-gated calcium channels, is being developed for treating neuropathic pain including diabetic peripheral neuropathy and postherpetic neuralgia. Mirogabalin possesses unique α₂δ subunit binding characteristics and has potent and long-lasting analgesic effects in neuropathic pain models. In the present study, we investigated the effects of mirogabalin on N-type calcium channel currents of the rat dorsal root ganglion (DRG) culture neurons using the whole-cell patch clamp technique. Read More

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http://dx.doi.org/10.1691/ph.2019.8833DOI Listing
March 2019
1 Read

Effects of Interactive Video Game-Based Exercise on Balance in Diabetic Patients with Peripheral Neuropathy: An Open-Level, Crossover Pilot Study.

Evid Based Complement Alternat Med 2019 6;2019:4540709. Epub 2019 Mar 6.

Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, Taiwan.

This study evaluated the effects of interactive video game-based (IVGB) exercise on balance in diabetic patients with peripheral neuropathy. Twenty-four patients were randomly assigned to two groups (12 participants per group). Group A received IVGB training for the first 6 weeks, with no exercise in the subsequent 6 weeks. Read More

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http://dx.doi.org/10.1155/2019/4540709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431378PMC
March 2019
2 Reads

The natural plant flavonoid apigenin is a strong antioxidant that effectively delays peripheral neurodegenerative processes.

Anat Sci Int 2019 Apr 4. Epub 2019 Apr 4.

Department of Anesthesiology and Pain Medicine, College of Medicine, Kosin University, 262, Gamcheon-ro, Seo-gu, Busan, 49267, Korea.

Oxidative stress contributes to the progression of neurodegenerative diseases of the central and peripheral nervous systems, including Alzheimer's disease, Parkinson's disease, stroke, and diabetic neuropathy. Despite the greater capability of peripheral nerves to regenerate compared with those in the brain or spinal cord, chronic oxidative stress leads to irreversible neurodegeneration in peripheral nerves. Thus, many efforts have been made to defend against irreversible peripheral nerve degeneration and oxidative stress. Read More

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http://dx.doi.org/10.1007/s12565-019-00486-2DOI Listing
April 2019
5 Reads

Biomarkers of response to alpha-lipoic acid ± palmitoiletanolamide treatment in patients with diabetes and symptoms of peripheral neuropathy.

Endocrine 2019 Apr 4. Epub 2019 Apr 4.

Department of Medicine, Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, Rome, Italy.

Purpose: To evaluate the effect of oral alpha-lipoic acid (ALA) ± palmitoyl-ethanolamide (PEA) on neuropathic symptoms in patients with diabetic peripheral neuropathy (DPN) and to identify factors related to the efficacy of the treatment.

Methods: This is a retrospective observational pilot study evaluating 49 patients with diabetes and positive Neuropathy Symptoms Score (NSS). Clinical and biochemical variables, including NSS, were compared between untreated patients and patients treated with oral 600 mg/day ALA ± 600 mg/day PEA at baseline (first occurrence of NSS ≥ 3) and at least 2 months after baseline. Read More

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http://dx.doi.org/10.1007/s12020-019-01917-wDOI Listing
April 2019
2 Reads

Metabolomic signature of type 1 diabetes-induced sensory loss and nerve damage in diabetic neuropathy.

J Mol Med (Berl) 2019 Apr 4. Epub 2019 Apr 4.

Institute of Pharmacology, Heidelberg University, Im Neuenheimer Feld 366, D-69120, Heidelberg, Germany.

Diabetic-induced peripheral neuropathy (DPN) is a highly complex and frequent diabetic late complication, which is manifested by prolonged hyperglycemia. However, the molecular mechanisms underlying the pathophysiology of nerve damage and sensory loss remain largely unclear. Recently, alteration in metabolic flux has gained attention as a basis for organ damage in diabetes; however, peripheral sensory neurons have not been adequately analyzed with respect to metabolic dysfunction. Read More

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http://dx.doi.org/10.1007/s00109-019-01781-1DOI Listing
April 2019
4 Reads

Predictors of poor glycemic control among patients with type 2 diabetes on follow-up care at a tertiary healthcare setting in Ethiopia.

BMC Res Notes 2019 Apr 4;12(1):207. Epub 2019 Apr 4.

School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia.

Objective: Contemporary clinical guidelines endorsed that glycemic control is the ultimate goal in the management patients with diabetes. The aim of this study was to assess the prevalence of glycemic control and to identify predictors of poor glycemic control in patients with type 2 diabetes (T2D). A cross-sectional study was conducted among systematically selected 357 diabetic patients. Read More

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http://dx.doi.org/10.1186/s13104-019-4248-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449968PMC
April 2019
1 Read

A Cost-Effectiveness Model for Adjunctive Smoked Cannabis in the Treatment of Chronic Neuropathic Pain.

Cannabis Cannabinoid Res 2019 13;4(1):62-72. Epub 2019 Mar 13.

Department of Psychiatry, University of California San Diego, La Jolla, California.

A recent meta-analysis affirmed the benefit of medicinal cannabis for chronic neuropathic pain, a disabling and difficult-to-treat condition. As medicinal cannabis use is becoming increasingly prevalent among Americans, an exploration of its economic feasibility is warranted. We present this cost-effectiveness analysis of adjunctive cannabis pharmacotherapy for chronic peripheral neuropathy. Read More

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http://dx.doi.org/10.1089/can.2018.0027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446169PMC
March 2019
3 Reads

The Effect of Daily Use of Plantar Mechanical Stimulation Through Micro-Mobile Foot Compression Device Installed in Shoe Insoles on Vibration Perception, Gait, and Balance in People With Diabetic Peripheral Neuropathy.

J Diabetes Sci Technol 2019 Apr 3:1932296819839703. Epub 2019 Apr 3.

1 Interdisciplinary Consortium on Advanced Motion Performance (iCAMP), Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.

Objective:: People with diabetic peripheral neuropathy (DPN) have impaired gait and balance performance. The aim of this study is to investigate therapeutic effectiveness of mechanical stimulation through a wearable foot compression device equipped in a shoe insole on vibration perception, balance control and gait performance in people with DPN.

Methods:: Using a single-arm 4-week intervention study design, we examined effectiveness of daily use of shoes equipped with the foot compression device (Footbeat™, AVEX, Grand Junction, CO, USA) on improving vibration perception threshold (VPT), skin perfusion pressure (SPP), ankle brachial index (ABI), lower extremities edema (circumferences in the calf and ankle), and motor performance (postural sway with eyes open and closed conditions, and gait performance during normal, dual-task and fast walking). Read More

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http://dx.doi.org/10.1177/1932296819839703DOI Listing
April 2019
4 Reads

Herbal medicinal products or preparations for neuropathic pain.

Cochrane Database Syst Rev 2019 Apr 2;4:CD010528. Epub 2019 Apr 2.

School of Health Sciences, Ulster University, Jordanstown campus, Shore Road, Newtownabbey, County Antrim, UK, BT37 0QB.

Background: Neuropathic pain is a consequence of damage to the central nervous system (CNS), for example, cerebrovascular accident, multiple sclerosis or spinal cord injury, or peripheral nervous system (PNS), for example, painful diabetic neuropathy (PDN), postherpetic neuralgia (PHN), or surgery. Evidence suggests that people suffering from neuropathic pain are likely to seek alternative modes of pain relief such as herbal medicinal products due to adverse events brought about by current pharmacological agents used to treat neuropathic pain. This review includes studies in which participants were treated with herbal medicinal products (topically or ingested) who had experienced neuropathic pain for at least three months. Read More

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http://dx.doi.org/10.1002/14651858.CD010528.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445324PMC
April 2019
4 Reads

Role of growth factors and cytokines in diabetic foot ulcer healing: A detailed review.

Rev Endocr Metab Disord 2019 Apr 1. Epub 2019 Apr 1.

Rajiv Gandhi Centre for Diabetes and Endocrinology, Faculty of Medicine, J.N. Medical College, Aligarh Muslim University, Aligarh, 202002, India.

The aim of the review is to examine the role of growth factors and cytokines in the management of Diabetic Foot Ulcers, such as platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and Insulin like growth factor (IGF). Taking this a step further, the role of Hypoxia-inducible factors (HIFs), Transforming growth factor beta 1 (TGF-β-1) and other growth factors have also been examined, with regard to the treatment of diabetic foot ulcers. The roles of these above-mentioned growth cytokines have been analyzed by studying various scholastic articles. Read More

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http://dx.doi.org/10.1007/s11154-019-09492-1DOI Listing
April 2019
2 Reads

Initial Diagnosis and Management for Acute Charcot Neuroarthropathy.

Kans J Med 2018 Nov 29;11(4):114-119. Epub 2018 Nov 29.

University of Kansas School of Medicine-Wichita, Department of Orthopaedics, Wichita, KS.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276967PMC
November 2018

Lumbar Spinal Cord Activity and Blood Biochemical Changes in Individuals With Diabetic Peripheral Neuropathy During Electrical Stimulation.

Front Neurol 2019 18;10:222. Epub 2019 Mar 18.

Department of Medical Imaging, Second Affiliated Hospital, Shantou University Medical College, Shantou, China.

It is difficult to perform an evaluation of the nerve conduction mechanism in a patient with diabetic peripheral neuropathy (DPN). We aim to explore possible activation differences to enable a further understanding of the nerve conduction mechanisms of diabetic neuropathy and to present a novel clinical method to evaluate nerve injury and recovery. DPN patients ( = 20) and healthy volunteers ( = 20) were included in this study to detect the functional activation of the lumbar spinal cord via electric stimulation. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00222
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http://dx.doi.org/10.3389/fneur.2019.00222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431615PMC
March 2019
7 Reads

Quantitative analysis of corneal nerve fibers in type 2 diabetics with and without diabetic peripheral neuropathy: Comparison of manual and automated assessments.

Diabetes Res Clin Pract 2019 Mar 30;151:33-38. Epub 2019 Mar 30.

Department of Endocrinology, Shanghai Jing'an District Central Hospital, Fudan University, Shanghai 200040, China. Electronic address:

Aims: To examine and compare fully-automated and manually measured corneal nerve fiber parameters in type 2 diabetes mellitus (T2DM) patients with and without diabetic peripheral neuropathy (DPN).

Methods: A total of 128 T2DM subjects and 24 healthy controls underwent neuropathy assessment and bilateral corneal confocal microscopy (CCM). Five representative nerve fiber images were selected for each participant and analyzed manually and with fully-automated software. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.039DOI Listing
March 2019
3 Reads
2.538 Impact Factor

AMPK in microvascular complications of diabetes and the beneficial effects of AMPK activators from plants.

Phytomedicine 2018 Dec 24. Epub 2018 Dec 24.

Department of Molecular Nutrition, CSIR-Central Food Technological Research Institute, Mysuru, Karnataka 570 020, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-CFTRI campus, Mysuru, Karnataka 570 020, India. Electronic address:

Background: Diabetes mellitus is a multifactorial disorder with the risk of micro- and macro-vascular complications. High glucose-induced derangements in metabolic pathways are primarily associated with the initiation and progression of secondary complications namely, diabetic nephropathy, neuropathy, and retinopathy. Adenosine monophosphate-activated protein kinase (AMPK) has emerged as an attractive therapeutic target to treat various metabolic disorders including diabetes mellitus. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.12.031DOI Listing
December 2018

Novel Insights into Sensorimotor and Cardiovascular Autonomic Neuropathy from Recent-Onset Diabetes and Population-Based Cohorts.

Trends Endocrinol Metab 2019 May 30;30(5):286-298. Epub 2019 Mar 30.

Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany; German Center for Diabetes Research (DZD), Partner Düsseldorf, Düsseldorf, Germany; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; These authors contributed equally. Electronic address:

The most prevalent chronic complications of diabetes are diabetic neuropathies, among which distal sensorimotor polyneuropathy (DSPN) and cardiovascular autonomic neuropathy (CAN) are the best studied. Their major clinical sequelae such as foot ulcers, neuropathic pain, and orthostatic hypotension are associated with lower quality of life and increased risk of mortality. Here we discuss the recent insights into DSPN and CAN focusing on two prospective cohorts; that is, the German Diabetes Study (GDS) including recent-onset diabetes patients and the population-based Cooperative Health Research in the Region of Augsburg, Germany (KORA) surveys. Read More

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http://dx.doi.org/10.1016/j.tem.2019.02.007DOI Listing
May 2019
2 Reads

Nano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: A randomized double-blind placebo- controlled clinical trial.

Complement Ther Med 2019 Apr 28;43:253-260. Epub 2019 Feb 28.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Diabetic Sensorimotor Polyneuropathy (DSPN) is a common complication of diabetes mellitus. Curcumin is the most important ingredient found in turmeric which has a very high potential for eliminating free radicals and inhibiting oxidative stress as an antioxidant agent. The aim of this study was to determine the effect of Nano-curcumin supplementation on the severity of sensorimotor polyneuropathy in patients with Type 2 diabetes mellitus (T2DM). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09652299183104
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http://dx.doi.org/10.1016/j.ctim.2019.02.014DOI Listing
April 2019
5 Reads

Functional gradient structural design of customized diabetic insoles.

J Mech Behav Biomed Mater 2019 Jun 6;94:279-287. Epub 2019 Mar 6.

John Scale Centre for Biomedical Engineering, University College London, Royal National Orthopaedic Hospital, Stanmore HA7 4LP, UK.

Diabetic foot is a common and serious complication of diabetes, largely due to sensory neuropathy and excessive mechanical stresses. Studies have shown that reducing the contact pressure can effectively lower the incidence of diabetic foot. A new design method is proposed in this study for optimizing the stress distribution of the contact surfaces between the foot and the insole by applying functional gradient structural properties to the insole. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17516161183174
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http://dx.doi.org/10.1016/j.jmbbm.2019.03.003DOI Listing
June 2019
6 Reads

Nitric oxide modulates μ-opioid receptor function in vitro.

Clin Exp Pharmacol Physiol 2019 Apr 1. Epub 2019 Apr 1.

School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

Painful diabetic neuropathy (PDN) is a type of peripheral neuropathic pain that develops as a consequence of prolonged hyperglycaemia-induced injury to the long nerves. Apart from pain, PDN is also characterized by morphine hyposensitivity. Intriguingly, in streptozotocin (STZ)-induced diabetic rats exhibiting marked morphine hyposensitivity, dietary administration of the nitric oxide (NO) precursor, L-arginine at 1 g/d, progressively rescued morphine efficacy and potency over an 8-week treatment period. Read More

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http://dx.doi.org/10.1111/1440-1681.13091DOI Listing
April 2019
3 Reads

NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies.

Nat Commun 2019 04 1;10(1):1467. Epub 2019 Apr 1.

Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine, Hermann-Rein-Str. 3, 37075, Göttingen, Germany.

In contrast to acute peripheral nerve injury, the molecular response of Schwann cells in chronic neuropathies remains poorly understood. Onion bulb structures are a pathological hallmark of demyelinating neuropathies, but the nature of these formations is unknown. Here, we show that Schwann cells induce the expression of Neuregulin-1 type I (NRG1-I), a paracrine growth factor, in various chronic demyelinating diseases. Read More

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http://dx.doi.org/10.1038/s41467-019-09385-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443727PMC
April 2019
2 Reads
10.742 Impact Factor

Vitamin D concentration is associated with diabetes peripheral neuropathy in older but not in young and middle-aged patients.

Diabetes Metab Res Rev 2019 Apr 1:e3162. Epub 2019 Apr 1.

Department of Clinical Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Background: The relationship between vitamin D and diabetes peripheral neuropathy (DPN) is not consistent among epidemiologic studies. Thus, we aimed to investigate this relationship in different age groups.

Methods: In this cross-sectional study, 1,461 patients admitted to the Department of Endocrinology at Xinhua Hospital from June 2016 to September 2017 were divided into three age groups: a Youth group (24-44 y, n=127), a Middle-age group (45-64 y, n=779) and an Elderly group (≥65 y, n=555). Read More

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http://dx.doi.org/10.1002/dmrr.3162DOI Listing
April 2019
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Relationship between Serum Asymmetric Dimethylarginine Level and Microvascular Complications in Diabetes Mellitus: A Meta-Analysis.

Biomed Res Int 2019 25;2019:2941861. Epub 2019 Feb 25.

Obstetrics Department, Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang 050000, Hebei, China.

Objective: The purpose of the meta-analysis was to evaluate the relationship between serum asymmetric dimethylarginine (ADMA) level and microvascular complications in diabetes mellitus (DM) including diabetic retinopathy (DR), diabetic neuropathy (DN), and diabetic nephropathy.

Methods: Studies were comprehensively identified by searching Web of Science, Embase, and PubMed databases up to August 30, 2018. The meta-analysis was carried out to compare the difference of serum ADMA concentrations of DR, DN, and diabetic nephropathy patients with healthy controls. Read More

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http://dx.doi.org/10.1155/2019/2941861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413490PMC
February 2019
3 Reads

Peripheral diabetic neuropathy: better prevent than cure.

Pol Arch Intern Med 2019 Mar 29;129(3):151-153. Epub 2019 Mar 29.

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http://dx.doi.org/10.20452/pamw.14773DOI Listing
March 2019
4 Reads

Vision Impairment in CKD Patients: Epidemiology, Mechanisms, Differential Diagnoses, and Prevention.

Am J Kidney Dis 2019 Mar 28. Epub 2019 Mar 28.

Singapore Eye Research Institute, Singapore National Eye Centre; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School. Electronic address:

Eyes and kidneys have numerous structural, developmental, physiologic, and pathogenic pathways in common, suggesting that many kidney and eye diseases may be interlinked. Studies suggest that the prevalence of eye diseases and vision impairment are higher among persons with end-stage kidney disease and earlier stages of chronic kidney disease (CKD) than in those without. Ocular morbidity in persons with CKD and end-stage kidney disease may be due to the following risk factors: (1) underlying conditions and risk factors for CKD such as diabetes or hypertension, (2) metabolic disorders associated with CKD, (3) uremia and anemia, and (4) CKD treatment. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.047DOI Listing
March 2019
5 Reads
5.900 Impact Factor

Prescribing practice of pregabalin/gabapentin in pain therapy: an evaluation of German claim data.

BMJ Open 2019 Mar 30;9(3):e021535. Epub 2019 Mar 30.

Department of General Medicine, Preventive and Rehabilitation Medicine, University of Marburg, Marburg, Germany.

Objectives: To analyse the prevalence and incidence of pregabalin and gabapentin (P/G) prescriptions, typical therapeutic uses of P/G with special attention to pain-related diagnoses and discontinuation rates.

Design: Secondary data analysis.

Setting: Primary and secondary care in Germany. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-021535DOI Listing
March 2019
2 Reads

1,25-(OH)D protects Schwann cells against advanced glycation end products-induced apoptosis through PKA-NF-κB pathway.

Life Sci 2019 Mar 27. Epub 2019 Mar 27.

Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China. Electronic address:

Aims: To explore the effect and mechanism of 1, 25-(OH)D on Schwann cell apoptosis induced by advanced glycation end products.

Main Methods: Schwann cells, isolated from rodent sciatic nerve were incubated with AGE-modified bovine serum albumin(AGE) to mimic diabetic conditions and 1,25-(OH)D was used as protector. Cell apoptosis was detected by PI/Annexin-V staining, caspase 3 activity assay and western blotting for caspase 3 and PARP. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.03.068DOI Listing
March 2019
3 Reads

DNA scaffold nanoparticles coated with HPMC/EC for oral delivery.

Int J Pharm 2019 May 27;562:321-332. Epub 2019 Mar 27.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60000, Pakistan.

The control of the glycemic level among diabetes/T2 patients is very important for their long term survival and avoiding further complexities including micro/macrovascular diseases as well as diabetic neuropathy. Vildagliptin (VD) is a drug that has addressed these issues successfully with the desired safety portfolio. We used DNA-nanocubes for initial nano-encapsulation of VD followed by HPMC/EC coating. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.03.054DOI Listing
May 2019
2 Reads
3.650 Impact Factor