27,557 results match your criteria Diabetic Neuropathy


Acoustic Radiation Force Impulse Elastography and Ultrasonographic Findings of Achilles Tendon in Patients With and Without Diabetic Peripheral Neuropathy: A Cross-Sectional Study.

Exp Clin Endocrinol Diabetes 2019 Feb 20. Epub 2019 Feb 20.

Department of Endocrinology and Metabolism, Başkent University, Ankara, Turkey.

Aims: We aimed to evaluate the elastographic features of Achilles tendon with Acoustic Radiation Force Impulse in patients with and without diabetic neuropathy.

Methods: According to the presence of peripheral neuropathy, 45 patients with type 2 diabetes were divided into 2 subgroups. Those with peripheral neuropathy were defined as group I (22 patients) and those without peripheral neuropathy were defined as group II (23 patients). Read More

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http://dx.doi.org/10.1055/a-0840-3292DOI Listing
February 2019

The risk factors for diabetic peripheral neuropathy: A meta-analysis.

PLoS One 2019 20;14(2):e0212574. Epub 2019 Feb 20.

Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang, Guizhou, China.

Diabetic peripheral neuropathy (DPN), the most common chronic complication of diabetes, has become an important public health crisis worldwide. Given that DPN is extremely difficult to treat, determining its risk factors and controlling it at an early stage is critical to preventing its serious consequences and the burden of social disease. Current studies suggest that the risk factors for diabetic peripheral neuropathy are the duration of diabetes, age, glycosylated hemoglobin A1c (HbA1c), diabetic retinopathy (DR), smoking, and body mass Index (BMI). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212574PLOS
February 2019

The contributions of mTOR activation-mediated upregulation of synapsin II and neurite outgrowth to hyperalgesia in STZ-induced diabetic rats.

ACS Chem Neurosci 2019 Feb 20. Epub 2019 Feb 20.

Painful diabetic neuropathy (PDN) is among the common complications in diabetes mellitus (DM), with its underlying mechanisms largely unknown. Synapsin II is primarily expressed in the spinal dorsal horn, and its upregulation mediates a superfluous release of glutamate and a deficiency of GABAergic interneuron synaptic transmission, which is directly implicated in the facilitation of pain signals in the hyperalgesic nociceptive response. Recently, synapsin II has been revealed to be associated with the modulation of neurite outgrowth, whereas the process of this neuronal structural neuroplasticity following neuronal hyperexcitability still remains unclear. Read More

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http://dx.doi.org/10.1021/acschemneuro.8b00680DOI Listing
February 2019

Inhibitory effect of valproate sodium on pain behavior in diabetic mice involves suppression of spinal histone deacetylase 1 and inflammatory mediators.

Int Immunopharmacol 2019 Feb 18;70:16-27. Epub 2019 Feb 18.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. Electronic address:

Anti-epileptic medications are included in the international guidelines for managing neuropathic pain. Valproate sodium (VPS) was recently described as "the forgotten analgesic" and has been reported to relief pain in various models of neuropathic pain. Some studies reported anti-inflammatory and histone deacetylase 1 (HDA1) inhibitory properties for sodium valproate. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.01.050DOI Listing
February 2019

A meta-analysis of the relationship between foot local characteristics and major lower extremity amputation in diabetic foot patients.

J Cell Biochem 2019 Feb 19. Epub 2019 Feb 19.

Department of Peripheral Vascular, Beijing University of Chinese Medicine, Dongzhimen Hospital, Beijing, China.

Objective: To clarify and quantify risk factors among local characteristics of the foot for major amputation in diabetic foot patients.

Methods: Articles published before January 2018 on PubMed and Embase were conducted observational studies about risk factors for major amputation in patients with diabetic foot were retrieved and systematically reviewed by using Stata 12.0 statistical software. Read More

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http://doi.wiley.com/10.1002/jcb.28183
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http://dx.doi.org/10.1002/jcb.28183DOI Listing
February 2019
1 Read

Diagnosing and managing diabetic somatic and autonomic neuropathy.

Ther Adv Endocrinol Metab 2019 4;10:2042018819826890. Epub 2019 Feb 4.

Weill Cornell Medicine-Qatar, Education City, Doha 24144, Qatar.

The diagnosis and management of diabetic neuropathy can be a major challenge. Late diagnosis contributes to significant morbidity in the form of painful diabetic neuropathy, foot ulceration, amputation, and increased mortality. Both hyperglycaemia and cardiovascular risk factors are implicated in the development of somatic and autonomic neuropathy and an improvement in these risk factors can reduce their rate of development and progression. Read More

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http://dx.doi.org/10.1177/2042018819826890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365998PMC
February 2019

Topical treatments for diabetic neuropathic pain.

Exp Ther Med 2019 Mar 15;17(3):1963-1976. Epub 2019 Jan 15.

Department of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.

Diabetic neuropathic pain (DNP) has a huge impact on quality of life and can be difficult to treat. Oral treatment is the most frequently used method for DNP, but its use is often limited by systemic side effects. Topical use of drugs as an alternative option for DNP treatment is currently gaining interest. Read More

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http://dx.doi.org/10.3892/etm.2019.7173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364237PMC

Suppression of autophagic activity by Rubicon is a signature of aging.

Nat Commun 2019 Feb 19;10(1):847. Epub 2019 Feb 19.

Department of Genetics, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan.

Autophagy, an evolutionarily conserved cytoplasmic degradation system, has been implicated as a convergent mechanism in various longevity pathways. Autophagic activity decreases with age in several organisms, but the underlying mechanism is unclear. Here, we show that the expression of Rubicon, a negative regulator of autophagy, increases in aged worm, fly and mouse tissues at transcript and/or protein levels, suggesting that an age-dependent increase in Rubicon impairs autophagy over time, and thereby curtails animal healthspan. Read More

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http://dx.doi.org/10.1038/s41467-019-08729-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381146PMC
February 2019

'Observing' diabetic neuropathy with corneal confocal microscopy: the effect of improvement of risk factors.

Authors:
Petr Boucek

Expert Rev Endocrinol Metab 2011 Nov;6(6):773-775

a Diabetes Centre, Institute for Clinical and Experimental Medicine, Videnska 9, 14021 Prague 4, Czech Republic.

Evaluation of: Tavakoli M, Kallinikos P, Iqbal A et al. Corneal confocal microscopy detects improvement in corneal nerve morphology with an improvement in risk factors for diabetic neuropathy. Diabet. Read More

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http://dx.doi.org/10.1586/eem.11.71DOI Listing
November 2011

Buckling Force Variability of Semmes⁻Weinstein Monofilaments in Successive Use Determined by Manual and Automated Operation.

Sensors (Basel) 2019 Feb 16;19(4). Epub 2019 Feb 16.

Human Informatics Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8566, Japan.

(1) Objective: This study was conducted with the objective of characterizing the variability of a force on a simulated skin surface using the Semmes⁻Weinstein monofilament test (SWMT). (2) Research Design and Methods: Two distinct experiments were performed to determine the effects of human hand motion variability on the monofilament buckling force, and to determine the monofilament's mechanical properties using a positioning stage. (3) Results: In manual operation (by human hand motion), the buckling force over the ten compressions decreased by over 10%, and the human hand motion variations during the SWMT may have impacted the buckling force. Read More

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http://dx.doi.org/10.3390/s19040803DOI Listing
February 2019

Intestinal nerve cell injury occurs prior to insulin resistance in female mice ingesting a high-fat diet.

Cell Tissue Res 2019 Feb 18. Epub 2019 Feb 18.

Department of Biological Sciences, University of Idaho, 875 Perimeter Drive, LSS 252, Moscow, ID, 83844, USA.

Diabetic patients suffer from gastrointestinal disorders associated with dysmotility, enteric neuropathy and dysbiosis of gut microbiota; however, gender differences are not fully known. Previous studies have shown that a high-fat diet (HFD) causes type two diabetes (T2D) in male mice after 4-8 weeks but only does so in female mice after 16 weeks. This study seeks to determine whether sex influences the development of intestinal dysmotility, enteric neuropathy and dysbiosis in mice fed HFD. Read More

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http://dx.doi.org/10.1007/s00441-019-03002-0DOI Listing
February 2019

Prevalence of peripheral arterial disease among diabetic patients in Santo Domingo, Dominican Republic and associated risk factors.

Arch Med Sci Atheroscler Dis 2018 15;3:e35-e40. Epub 2018 Feb 15.

Shanghai Xin Hua Hospital affiliated to the Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

Introduction: Peripheral arterial disease (PAD) is a major risk factor of coronary artery disease and a major complication of atherosclerosis. Peripheral arterial disease can be diagnosed with simple and low cost techniques. There are major risk factors of PAD that have been studied for different countries. Read More

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http://dx.doi.org/10.5114/amsad.2018.73527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374585PMC
February 2018

Effect of diabetes on neurological adverse effects and chemotherapy induced peripheral neuropathy in advanced colorectal cancer patients treated with different FOLFOX regimens.

Pak J Pharm Sci 2019 Jan;32(1):125-130

Department Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

This retrospective study reports impact of diabetes on incidence rate of dose limiting symptoms of neurological toxicity and chemotherapy induced peripheral neuropathy (CIPN). Post-surgical colorectal cancer (CRC) patients with metastatic disease, treated with four different schedules of FOLFOX were included in this study. Neurological adverse effects were assessed by CTC v2. Read More

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January 2019
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Ankle fusion following failed initial treatment of complex ankle fractures in neuropathic diabetics.

Foot Ankle Surg 2019 Feb 5. Epub 2019 Feb 5.

The Department of Orthopaedic Surgery and Rehabilitation, Loyola University Health System, 2160 South First Avenue, Maywood, IL 60153, United States. Electronic address:

Background: Unstable ankle fractures in diabetics with peripheral neuropathy have an increased risk of postoperative complications, often leading to amputation. Primary ankle arthrodesis has been suggested as an alternative when acceptable reduction and mechanical stabilization cannot be obtained.

Methods: Over a fourteen year period, thirteen diabetic patients with peripheral neuropathy underwent an attempt at primary ankle arthrodesis following the early post-fracture development of acute neuropathic (Charcot) deformity of the ankle after sustaining a low energy unstable ankle fracture. Read More

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http://dx.doi.org/10.1016/j.fas.2019.01.010DOI Listing
February 2019
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Reliability of peak foot pressure in patients with previous diabetic foot ulceration.

Gait Posture 2019 Feb 4;70:6-11. Epub 2019 Feb 4.

Department of Physiotherapy, Singapore General Hospital, Singapore. Electronic address:

Background: Previous reliability studies on peak plantar pressure measurements in patients with previous diabetic foot ulceration (DFU) did not stratify their analyses according to whether the foot had a previous ulcer.

Research Question: Does test-retest reliability of peak foot pressure measurements from the various foot regions differ between the ulcerated and non-ulcerated feet?

Methods: Data from 23 participants with peripheral neuropathy and healed plantar DFU were analysed in this test-retest reliability comparison study. Plantar pressure was evaluated on two sessions using Pedar-X in-shoe system, with a mean of 7. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2019.02.001DOI Listing
February 2019
2 Reads

Plant-derived medicines for neuropathies: a comprehensive review of clinical evidence.

Rev Neurosci 2019 Feb 15. Epub 2019 Feb 15.

Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran 14167-53955, Iran.

Neuropathy is defined as the damage to the peripheral or central nervous system accompanied by pain, numbness, or muscle weakness, which can be due to congenital diseases or environmental factors such as diabetes, trauma, or viral infections. As current treatments are not sufficiently able to control the disease, studies focusing on the identification and discovery of new therapeutic agents are necessary. Natural products have been used for a long time for the management of different neurological problems including neuropathies. Read More

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http://dx.doi.org/10.1515/revneuro-2018-0097DOI Listing
February 2019

Clinical Predictors of Diabetic Retinopathy Progression; A Systematic Review.

Curr Diabetes Rev 2019 Feb 15. Epub 2019 Feb 15.

Department of Ophthalmology, Faculty of Medicine, Taif University, Taif. Saudi Arabia.

Objective: The study aims to review the published clinical predictors of Diabetic Retinopathy Progression and discuss their level of clinical significance.

Methods: The data for systematic review has been gathered from the studies that were searched through scholarly platforms and several libraries. These studies discussed the clinical predictors of Diabetic Retinopathy (DR) progression. Read More

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http://dx.doi.org/10.2174/1573399815666190215120435DOI Listing
February 2019
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Investigation of the utility of Curcuma caesia in the treatment of diabetic neuropathy.

J Pharm Pharmacol 2019 Feb 14. Epub 2019 Feb 14.

Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.

Objectives: Curcuma caesia has shown positive results in treating number of diseases, but till date no work was reported on its activity in diabetic neuropathy. So, the present review aims at exploring several hypothesis which can be proposed to explain further its utility in diabetic neuropathy by its antioxidant property, anti-inflammatory, CNS depressant effect, antibacterial and antifungal property. For finding the accurate and exact detail, a thorough review of all the available research and review article was done. Read More

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http://dx.doi.org/10.1111/jphp.13075DOI Listing
February 2019
2 Reads

Neurons and Microglia; A Sickly-Sweet Duo in Diabetic Pain Neuropathy.

Front Neurosci 2019 31;13:25. Epub 2019 Jan 31.

Département de Pharmacologie et Physiologie, Faculté de Médecine, Université de Montréal, Montréal, QC, Canada.

Diabetes is a common condition characterized by persistent hyperglycemia. High blood sugar primarily affects cells that have a limited capacity to regulate their glucose intake. These cells include capillary endothelial cells in the retina, mesangial cells in the renal glomerulus, Schwann cells, and neurons of the peripheral and central nervous systems. Read More

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http://dx.doi.org/10.3389/fnins.2019.00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365454PMC
January 2019
1 Read

Development of Charcot Neuroarthropathy in Diabetic Patients who Received Kidney or Kidney-Pancreas Transplants.

J Foot Ankle Surg 2019 Feb 11. Epub 2019 Feb 11.

Assistant Professor, Podiatric Medicine and Surgery Residency Program, The Ohio State University Wexner Medical Center, Columbus, OH.

Only a small percentage of the general diabetic population develops Charcot neuroarthropathy. Charcot arthropathy greatly increases the risk of foot complications. At our academic institution, there appeared to be an increased incidence of Charcot arthropathy in transplant patients. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.09.022DOI Listing
February 2019
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Lens autofluorescence ratio as a noninvasive marker of peripheral diabetic neuropathy.

Pol Arch Intern Med 2019 Feb 14. Epub 2019 Feb 14.

INTRODUCTION Diabetes and its complications are a significant cause of morbidity and mortality. Advanced glycation endproducts (AGEs) play a major role in the pathogenesis of  diabetes complications. OBJECTIVES To investigate the possible uses of a biomicroscope (ClearPath DS-120) that shows age-adjusted lens fluorescence ratios (LFRs) for the diagnosis of diabetic peripheral neuropathy (DPN). Read More

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http://dx.doi.org/10.20452/pamw.4449DOI Listing
February 2019
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Lumbosacral radiculoplexus neuropathy: Incidence and the association with diabetes mellitus.

Neurology 2019 Feb 13. Epub 2019 Feb 13.

From the Department of Neurology (P.S.N.), National Neuroscience Institute, Singapore; Department of Neurology (P.S.N., P.J.D., R.S.L., M.V.P., P.J.B.D.), and Division of Biomedical Statistics and Informatics (P.T.), Mayo Clinic, Rochester, MN.

Objective: To determine the previously unknown incidence of lumbosacral-radiculoplexus neuropathy (LRPN) and its association with diabetes mellitus (DM).

Methods: LRPN defined by clinical and electrophysiologic criteria was identified among Olmsted County, Minnesota, residents during a 16-year period (2000-2015) using the unique facilities of the Rochester Epidemiology Project. DM was ascertained using American Diabetes Association criteria. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007020DOI Listing
February 2019
2 Reads

Antihypernociceptive and neuroprotective effects of Combretin A and Combretin B on streptozotocin-induced diabetic neuropathy in mice.

Naunyn Schmiedebergs Arch Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan.

Painful diabetic neuropathy (PDN) is known to adversely affect psychosocial functioning by enhancing levels of anxiety and depression. This study was designed to verify the antihypernociceptive, anxiolytic, and antidepressant-like effects of Combretin A and Combretin B (two triterpenes cycloartane-type isolated from the leaves of Combretum fragrans) in streptozotocin-induced diabetic neuropathy in mice. PDN was induced in mice by the administration of streptozotocin (STZ, 200 mg/kg, i. Read More

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http://dx.doi.org/10.1007/s00210-019-01626-1DOI Listing
February 2019
1 Read

Cardiovascular autonomic neuropathy in type 2 diabetic patients.

Rev Assoc Med Bras (1992) 2019 Jan;65(1):56-60

Full Professor - Department of Cardiology - Laboratory of Vascular Biology and Atherosclerosis - FCM - Unicamp - São Paulo (SP) - Brasil.

Diabetes is one of the most common chronic pathologies around the world, involving treatment with general clinicians, endocrinologists, cardiologists, ophthalmologists, nephrologists and a multidisciplinary team. Patients with type 2 Diabetes Mellitus (T2DM) can be affected by cardiac autonomic neuropathy, leading to increased mortality and morbidity. In this review, we will present current concepts, clinical features, diagnosis, prognosis, and possible treatment. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
Publisher Site
http://dx.doi.org/10.1590/1806-9282.65.1.56DOI Listing
January 2019
3 Reads

Obstructive and non-obstructive coronary artery disease in long-lasting type 1 diabetes: a 7-year prospective cohort study.

Pol Arch Intern Med 2019 Feb 13. Epub 2019 Feb 13.

INTRODUCTION It is widely believed that patients with diabetes are at increased risk of severe and premature coronary artery disease (CAD) when compared to non-diabetic individuals. OBJECTIVES To evaluate the prevalence, 7-year incidence, predictors, and outcomes of obstructive and non-obstructive CAD in patients with long-lasting type 1 diabetes. PATIENTS AND METHODS We enrolled 2330 patients at a median age of 50 years with a median diabetes duration of 32 years. Read More

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http://dx.doi.org/10.20452/pamw.4440DOI Listing
February 2019
1 Read

Whole-methylome analysis of circulating monocytes in acute diabetic Charcot foot reveals differentially methylated genes involved in the formation of osteoclasts.

Epigenomics 2019 Feb 1;11(3):281-296. Epub 2018 Nov 1.

Epigenetics Cardiovascular Laboratory, Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar.

Aim: To assess whether DNA methylation of monocytes play a role in the development of acute diabetic Charcot foot (CF).

Patients & Methods: We studied the whole methylome (WM) of circulating monocytes in 18 patients with Type 2 diabetes (T2D) and acute CF, 18 T2D patients with equivalent neuropathy and 18 T2D patients without neuropathy, using the enhanced reduced representation bisulfite sequencing technique.

Results & Conclusion: WM analysis demonstrated that CF monocytes are differentially methylated compared with non-CF monocytes, in both CpG-site and gene-mapped analysis approaches. Read More

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http://dx.doi.org/10.2217/epi-2018-0144DOI Listing
February 2019
1 Read

Neurologic Conditions: Common Peripheral Neuropathies.

FP Essent 2019 Feb;477:11-15

University of South Alabama College of Medicine Department of Family Medicine, 1601 Center Street, 2N Mobile, AL 36604.

Peripheral neuropathies (PNs) are a group of conditions caused by damage to the peripheral nervous system. PN is a condition commonly seen in the family medicine setting and can lead to reduced quality of life due to pain, ulceration, and falls. More than 100 etiologies of PN have been identified; the most common are metabolic, drug-related, and systemic etiologies. Read More

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February 2019
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Fructose-induced insulin resistance as a model of neuropathic pain in rats.

Neuroscience 2019 Feb 8. Epub 2019 Feb 8.

Departamento de Farmacobiología, Cinvestav, Sede Sur. Mexico City, Mexico. Electronic address:

Peripheral neuropathy is one of the main complications of diabetes. The pathogenesis of this affectation is not completely understood. Several studies refer to hyperglycemia as the principal cause of diabetic neuropathy. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.01.063DOI Listing
February 2019
1 Read

The Correlation between Malondialdehyde and Nerve Growth Factor Serum Level with Diabetic Peripheral Neuropathy Score.

Open Access Maced J Med Sci 2019 Jan 14;7(1):103-106. Epub 2019 Jan 14.

Universitas Andalas, Pharmacy Padang, Sumatera Barat, Padang, Indonesia.

Aim: This study was conducted to identify malondialdehyde (MDA) serum level, nerve growth factor (NGF) serum level, diabetic peripheral neuropathy score and the correlation between MDA and NGF serum level with diabetic peripheral neuropathy score.

Methods: A cross-sectional study was conducted to observe diabetic patients in the internal medicine department in Dr M. Djamil Hospital, Padang, Indonesia. Read More

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http://dx.doi.org/10.3889/oamjms.2019.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352465PMC
January 2019
1 Read

Permanent damage of the sciatic nerve in an 8-year-old girl with newly diagnosed type 1 diabetes.

Paediatr Int Child Health 2019 Feb 11:1-3. Epub 2019 Feb 11.

a 4th Department of Pediatrics, School of Medicine, Faculty of Health Sciences , Aristotle University of Thessaloniki, Papageorgiou General Hospital , Thessaloniki , Greece.

Neuropathy, a complication of type 1 diabetes (T1D), is a heterogeneous group, and chronic polyneuropathy is the most common form in adults. Αn 8-year-old girl admitted with severe diabetic ketoacidosis was diagnosed with T1D. She was managed with intravenous fluids and insulin and was subsequently commenced on multiple daily subcutaneous injections of insulin. Read More

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http://dx.doi.org/10.1080/20469047.2019.1575536DOI Listing
February 2019
1 Read

Diabetic neuropathies influence recovery from hip-fracture surgery in older persons with diabetes.

Exp Gerontol 2019 Feb 7;119:168-173. Epub 2019 Feb 7.

Healthy Aging Research Center, Chang Gung University, 259 Wenhua 1st Road, Guishan District, Taoyuan 33302, Taiwan; School of Nursing, College of Medicine, Chang Gung University, 259 Wenhua 1st Road, Guishan District, Taoyuan 33302, Taiwan; Department of Orthopedic Surgery, Linkou Chang Gung Memorial Hospital, 5 Fuxing Street, Guishan District, Taoyuan 33305, Taiwan; Department of Nursing, Kaohsiung Chang Gung Memorial Hospital, 123 Dapi Road, Niaosng District, Kaohsiung 83301, Taiwan; Department of Gerontology and Health Care Management, Chang Gung University of Science and Technology, 261 Wenhwa 1st Road, Guishan District, Taoyuan 33303, Taiwan. Electronic address:

Background/objectives: To explore the impact of diabetic peripheral neuropathy (DPN) on the recovery of older persons with diabetes mellitus (DM) after hip-fracture surgery.

Design, Setting, Participants: Secondary data for this study came from a clinical trial on the effectiveness of a DM-specific care model for 176 older persons (age ≥ 60) with DM over 2 years following hip-fracture surgery at a medical center in Taiwan. In the original trial, the experimental group (n = 88) received DM-specific care comprising diabetes care plus subacute care, and the control group (n = 88) received only usual care. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.004DOI Listing
February 2019
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Insights for Care: The Healthcare Utilisation and Cost Impact of Managing Type 2 Diabetes-Associated Microvascular Complications.

Diabetes Ther 2019 Feb 8. Epub 2019 Feb 8.

Heart of England NHS Foundation Trust, Birmingham, UK.

Introduction: The increasing prevalence of type 2 diabetes (T2DM) in the UK imposes a significant burden on the National Health Service (NHS). Despite the availability of effective treatments, the loss of glycaemic control over time results in significant comorbidities, including nephropathy, neuropathy and retinopathy. The cost of treating these microvascular complications has not been well documented, and this study aimed to provide an accurate assessment of the healthcare resource utilisation (HCRU) associated with managing T2DM and its complications. Read More

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http://dx.doi.org/10.1007/s13300-018-0548-4DOI Listing
February 2019
1 Read

Diagnosis of cardiovascular autonomic neuropathy in diabetes: as simple as possible, but not simpler? An answer.

Authors:
G Bax F Bellavere

Acta Diabetol 2019 Feb 8. Epub 2019 Feb 8.

Endocrinology and Diabetes section "Rizzola" Foundation Hospital, San Donà, Venezia, Italy.

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http://dx.doi.org/10.1007/s00592-018-01281-7DOI Listing
February 2019
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Verapamil Attenuated Prediabetic Neuropathy in High-Fat Diet-Fed Mice through Inhibiting TXNIP-Mediated Apoptosis and Inflammation.

Oxid Med Cell Longev 2019 10;2019:1896041. Epub 2019 Jan 10.

Department of Endocrinology, Nanfang Hospital, Southern Medical University, China.

Diabetic neuropathy (DN) is a common and severe complication of diabetes mellitus. There is still a lack of an effective treatment to DN because of its complex pathogenesis. Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of thioredoxin, has been shown to be associated with diabetic retinopathy and nephropathy. Read More

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http://dx.doi.org/10.1155/2019/1896041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348807PMC
January 2019
1 Read

The Effect of Sodium Channel Blocker, Mexiletine, on Body Weight in Type 2 Diabetes Patients with Visceral Obesity.

Authors:
Naohiko Ueno

Clin Med Insights Endocrinol Diabetes 2019 22;12:1179551418825049. Epub 2019 Jan 22.

Ueno Internal Medicine and Diabetes Clinic, Kobe, Japan.

Objective: Mexiletine is an anti-arrhythmic agent also used for the treatment of painful diabetic neuropathy. In this study, the effect of mexiletine on body weight was evaluated in type 2 diabetes patients with diabetic neuropathy exhibiting visceral obesity.

Methods: Type 2 diabetes patients with neuropathy exhibiting visceral obesity (n = 21) treated by mexiletine (300 mg/day) and a control group of type 2 diabetes patients with the same condition who received vitamin B (n = 12) were retrospectively evaluated. Read More

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http://dx.doi.org/10.1177/1179551418825049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343451PMC
January 2019
1 Read

Brain spectroscopy reveals that N-acetylaspartate is associated to peripheral sensorimotor neuropathy in type 1 diabetes.

J Diabetes Complications 2019 Jan 4. Epub 2019 Jan 4.

Department of Clinical Medicine, Aalborg University, Søndre Skovvej 11, 9000 Aalborg, Denmark; Mech-Sense, Department of Gastroenterology & Hepatology, Aalborg University Hospital, Mølleparkvej 4, 9000 Aalborg, Denmark; Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.

Aims: Emerging evidence shows, that distal symmetric peripheral neuropathy (DSPN) also involves alterations in the central nervous system. Hence, the aims were to investigate brain metabolites in white matter of adults with diabetes and DSPN, and to compare any cerebral disparities with peripheral nerve characteristics.

Methods: In type 1 diabetes, brain metabolites of 47 adults with confirmed DSPN were compared with 28 matched healthy controls using proton magnetic resonance spectroscopy (H-MRS) in the parietal region including the sensorimotor fiber tracts. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2018.12.016DOI Listing
January 2019
1 Read

Effect of folic acid supplementation on nerve conduction velocity in diabetic polyneuropathy patients.

Neurol Res 2019 Feb 7:1-5. Epub 2019 Feb 7.

e Department of Community Nutrition, School of Nutrition and Food Science , Isfahan University of Medical Sciences , Isfahan , Iran.

Objectives: In diabetic polyneuropathy (DPN) patients, the effect of folic acid and homocysteine has been related to components of nerve conduction velocity (NCV). The objective of this study was to determine the effect of folic acid supplementation on NCV in DPN patients.

Methods: Patients were randomized to receive either 1 mg of folic acid (n = 40) or placebo (n = 40) for 16 weeks. Read More

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http://dx.doi.org/10.1080/01616412.2019.1565180DOI Listing
February 2019
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1.449 Impact Factor

Predictors of Diabetic Foot Reulceration beneath the Hallux.

J Diabetes Res 2019 8;2019:9038171. Epub 2019 Jan 8.

Diabetic Foot Unit, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.

Aims: To evaluate the factors that predict reulceration beneath the hallux in people with a history of diabetic foot ulceration.

Methods: A prospective study conducted between January 2012 and December 2014 was performed in a diabetic foot unit to assess the risk factors associated with hallux reulceration. Sixty patients with diabetic neuropathy and a history of previous ulcer were consecutively included. Read More

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http://dx.doi.org/10.1155/2019/9038171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341251PMC
January 2019
3 Reads

Comparison Of Thermal Foot Maps Between Diabetic Patients With Neuropathic, Vascular, Neurovascular, And No Complications.

Curr Diabetes Rev 2019 Feb 6. Epub 2019 Feb 6.

Department of Nursing, University of Extremadura, Avda. Virgen del Puerto s/n. Spain.

Background: Diabetes mellitus is a public health problem worldwide. The diabetic foot has a degenerate vascular structure, and its patients present neurological problems, which require the earliest possible identification.

Introduction: The objective of the research was to use infrared thermography to analyze the temperature difference of the feet of users with diabetes mellitus with neuropathy, vasculopathy, neurovascular disease, or none of them, segmenting the sole of the foot in four areas for the study. Read More

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http://dx.doi.org/10.2174/1573399815666190206160711DOI Listing
February 2019
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Acute effects of hyperglycemia on the peripheral nervous system in zebrafish ( Danio Rerio) following nitroreductase-mediated β-cell ablation.

Am J Physiol Regul Integr Comp Physiol 2019 Feb 6. Epub 2019 Feb 6.

Biological Sciences, Salisbury University, United States.

Diabetic peripheral neuropathy (DPN) is estimated to affect 50% of diabetic patients. Although highly prevalent, molecular mechanisms remain unknown and treatment is limited to pain relief and glycemic control. Here, we provide a novel model of acute DPN in zebrafish (Danio Rerio)larvae. Read More

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http://dx.doi.org/10.1152/ajpregu.00258.2018DOI Listing
February 2019
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Nanoparticle-microRNA-146a-5p polyplexes ameliorate diabetic peripheral neuropathy by modulating inflammation and apoptosis.

Nanomedicine 2019 Feb 2. Epub 2019 Feb 2.

Department of Endocrinology, Jinshan Hospital, Fudan University, NO.1508, Longhang Road, Shanghai, 201508, China. Electronic address:

Nontoxic and nonimmunogenic nanoparticles play an increasingly important role in the application of pharmaceutical nanocarriers. The pathogenesis of diabetic peripheral neuropathy (DPN) has been extensively studied. However, the role of microRNAs in DPN remains to be clarified. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193001
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http://dx.doi.org/10.1016/j.nano.2019.01.007DOI Listing
February 2019
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α5GABAA receptors play a pro-nociceptive role and avoid the rate dependent depression of the Hoffmann reflex in diabetic neuropathic pain and reduce primary afferent excitability.

Pain 2019 Jan 31. Epub 2019 Jan 31.

Departamento de Fisiología, Biofísica y Neurociencias, Cinvestav, Mexico City, Mexico.

Diabetic neuropathy is an incapacitating complication in diabetic patients. The cellular and molecular mechanisms involved in this pathology are poorly understood. Previous studies have suggested that the loss of spinal GABAergic inhibition participate in painful diabetic neuropathy. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001515DOI Listing
January 2019
2 Reads

Correlation of systemic arterial stiffness with changes in retinal and choroidal microvasculature in type 2 diabetes.

Sci Rep 2019 Feb 4;9(1):1401. Epub 2019 Feb 4.

Department of Ophthalmology and Visual Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

This study was conducted to assess whether systemic arterial stiffness, indicated by cardio-ankle vascular index (CAVI), is related to changes in the microvasculature of the retina and choroid in diabetes mellitus (DM). This study included 113 patients with a confirmed diagnosis of type-2 DM. Among them, 18 patients did not have diabetic retinopathy (DR), 71 had non-proliferative DR (NPDR), and 24 had proliferative DR (PDR). Read More

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http://dx.doi.org/10.1038/s41598-018-37969-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361886PMC
February 2019

Premedication With Gabapentin Significantly Reduces the Risk of Postherpetic Neuralgia in Patients With Neuropathy.

Mayo Clin Proc 2019 Feb 1. Epub 2019 Feb 1.

Department of Dermatology, Mayo Clinic, Scottsdale, AZ. Electronic address:

Postherpetic neuralgia (PHN) is the most common complication of varicella zoster virus (VZV) reactivation and a cause of considerable physical and psychosocial morbidity. No known treatment effectively prevents the development of PHN in patients with VZV reactivation. In this study, our objective was to evaluate the efficacy of premedication with gabapentin for reducing the risk of PHN in patients with diabetic and nondiabetic neuropathy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00256196183088
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http://dx.doi.org/10.1016/j.mayocp.2018.11.004DOI Listing
February 2019
6 Reads

Is health related quality of life influenced by diabetic neuropathic pain among type II diabetes mellitus patients in Ethiopia?

PLoS One 2019 4;14(2):e0211449. Epub 2019 Feb 4.

Department of Preventive Medicine, School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Polyneuropathy is one of the commonest complications of long-standing diabetes. Progressive sensory loss can predispose patients to foot ulcer and the neuropathy oftentimes causes pain. The pain can significantly affect the quality of life of patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211449PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361436PMC
February 2019
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Comparative study on laser and LED influence on tissue repair and improvement of neuropathic symptoms during the treatment of diabetic ulcers.

Lasers Med Sci 2019 Feb 4. Epub 2019 Feb 4.

Department of Physical Therapy, Federal University of Ceará, Fortaleza, Brazil.

To compare the influence of laser and LED on tissue repair and neuropathic symptoms during treatment of diabetic foot. An intervention survey conducted in a health center located in Brazil, contemplating ten sessions, twice a week, with randomization in two groups. In one group, the wounds were treated with GaAlAs laser, with a wavelength of 830 nm, 30 mW, and power density 0. Read More

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http://dx.doi.org/10.1007/s10103-019-02724-5DOI Listing
February 2019
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Gait changes in persons with diabetes: Early risk marker for diabetic foot ulcer.

Foot Ankle Surg 2019 Jan 26. Epub 2019 Jan 26.

Prof. M. Viswanathan Diabetes Research Centre, West Mada Church Street, Royapuram, Chennai, 600013, India. Electronic address:

Background Increasing prevalence of diabetic foot ulcer (DFU) and subsequent foot amputation in persons with type 2 diabetic neuropathy is a well known fact. The present study was aimed to identify the initial risk marker for DFU. Methods Dynamic plantar pressure analysis was done for persons with type 2 diabetes mellitus (T2DM) without neuropathy (D), patients with diabetic neuropathy (DN) with normal foot profile and healthy persons with normal foot profile (C). Read More

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http://dx.doi.org/10.1016/j.fas.2019.01.005DOI Listing
January 2019
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Peripheral Neuropathy.

Med Clin North Am 2019 Mar 17;103(2):383-397. Epub 2018 Dec 17.

Department of Neurology, Virginia Commonwealth University, 417 North 11th Street, Richmond, VA 23298, USA.

Peripheral neuropathy is a commonly encountered disorder in clinical practice. In light of an aging population and the diabetes and obesity pandemic, the prevalence of peripheral neuropathy is increasing, posing a significant public health concern. This article provides a diagnostic framework for neuropathies and summarizes treatment options. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.10.006DOI Listing
March 2019
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Novel nanocapsule of α-lipoic acid reveals pigmentation improvement: α-Lipoic acid stimulates the proliferation and differentiation of keratinocyte in murine skin by topical application.

Exp Dermatol 2019 Feb;28 Suppl 1:55-63

Department of Research and Development, Nanoegg Research Laboratories, Inc. Advanced Medicine and Healthcare Research Laboratories, Kawasaki-shi, Kanagawa, Japan.

α-Lipoic acid is amphipathic with low molecular sulphur-containing fatty acid and has strong antioxidant effects. It has been used at the purposes of anti-ageing, treatment of diabetic neuropathy, and supplement as antioxidant. Though α-lipoic acid is normally administered in oral or injection, it has not been used in a topical use via skin because of its bad penetration. Read More

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http://dx.doi.org/10.1111/exd.13828DOI Listing
February 2019
3 Reads