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    Targeting heme oxygenase-1 in early diabetic nephropathy in streptozotocin-induced diabetic rats.
    Physiol Int 2016 Dec;103(4):413-427
    1 Physiology Department, Faculty of Medicine, Tanta University , Tanta, Egypt.
    Diabetic nephropathy (DN) is one of the most common microvascular diabetic complications. This study was designed to evaluate the possible protective effect and underlying mechanisms of HO-1 induction in streptozotocin (STZ)-induced early DN in rats. The diabetic rats were divided into three groups: STZ-diabetic, cobalt protoporphyrin (CoPP)-treated diabetic, and zinc protoporphyrin IX (ZnPP)-treated diabetic groups. Read More

    Accumulation of worn-out GBM material substantially contributes to mesangial matrix expansion in diabetic nephropathy.
    Am J Physiol Renal Physiol 2017 Feb 22:ajprenal.00020.2017. Epub 2017 Feb 22.
    German Cancer Research Center.
    Thickening of the glomerular basement membrane (GBM) and expansion of the mesangial matrix are hallmarks of diabetic nephropathy (DN) generally considered to emerge from different sites of overproduction; GBM components from podocytes and mesangial matrix from mesangial cells. Re-evaluation of 918 biopsies with DN revealed strong evidence that these mechanisms are connected to each other, wherein excess GBM components fail to undergo degradation and are deposited in the mesangium. These data do not exclude that also mesangial cells synthesize components that contribute to the accumulation of matrix in the mesangium. Read More

    Autophagy Protects against Palmitic Acid-Induced Apoptosis in Podocytes in vitro.
    Sci Rep 2017 Feb 22;7:42764. Epub 2017 Feb 22.
    Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Chongqing, 400042, China.
    Autophagy is a highly conserved degradation process that is involved in the clearance of proteins and damaged organelles to maintain intracellular homeostasis and cell integrity. Type 2 diabetes is often accompanied by dyslipidemia with elevated levels of free fatty acids (FFAs). Podocytes, as an important component of the filtration barrier, are susceptible to lipid disorders. Read More

    Effect of triptolide on expression of oxidative carbonyl protein in renal cortex of rats with diabetic nephropathy.
    J Huazhong Univ Sci Technolog Med Sci 2017 Feb 22;37(1):25-29. Epub 2017 Feb 22.
    Laboratory Animal Science Department, Fudan University, Shanghai, 200032, China.
    The traditional Chinese medicine (Tripterygium wilfordiiHook.f., TWH) has been clinically used to treat primary and secondary renal diseases and proteinuria for nearly 40 years. Read More

    PARP inhibition ameliorates nephropathy in an animal model of type 2 diabetes: focus on oxidative stress, inflammation, and fibrosis.
    Naunyn Schmiedebergs Arch Pharmacol 2017 Feb 21. Epub 2017 Feb 21.
    Department of Pharmacology, Faculty of Pharmacy, Zagazig University, P.O. Box 44519, Zagazig, Egypt.
    Poly(ADP-ribose) polymerase (PARP) enzyme contributes to nephropathy, a serious diabetic complication which may lead to end-stage renal disease. The study aims to investigate the effect of PARP over-activation on kidney functions in a type 2 diabetic rat model. The study also tests the therapeutic use of PARP inhibitors in diabetic nephropathy. Read More

    Rethinking CKD Evaluation: Should We Be Quantifying Basal or Stimulated GFR to Maximize Precision and Sensitivity?
    Am J Kidney Dis 2017 Feb 17. Epub 2017 Feb 17.
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indiana Center for Biological Microscopy, Rouderbush VA, Indianapolis, IN. Electronic address:
    Chronic kidney disease (CKD) is an increasing clinical problem. Although clinical risk factors and biomarkers for the development and progression of CKD have been identified, there is no commercial surveillance technology to definitively diagnose and quantify the severity and progressive loss of glomerular filtration rate (GFR) in CKD. This has limited the study of potential therapies to late stages of CKD when FDA-registerable events are more likely. Read More

    High Glucose Induces Mouse Mesangial Cell Overproliferation via Inhibition of Hydrogen Sulfide Synthesis in a TLR-4-Dependent Manner.
    Cell Physiol Biochem 2017 Feb 22;41(3):1035-1043. Epub 2017 Feb 22.
    Background/aims: Overproliferation of mesangial cells was believed to play an important role in the progress of diabetic nephropathy, one of the primary complications of diabetes. Hydrogen sulfide (H2S), a well-known and pungent gas with the distinctive smell of rotten eggs, was discovered to play a protective role in diabetic nephropathy.

    Methods: MTT assay was used to examine the viability of mesangial cells. Read More

    A low prevalence of non alcoholic fatty liver disease in patients with type 1 diabetes is associated to decreased subclinical cardiovascular disease.
    J Diabetes 2017 Feb 20. Epub 2017 Feb 20.
    Service of Endocrinology and Nutrition, Department of Medicine, Institute of Research and Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, CIBERDEM and CIBERER, Instituto de Salud Carlos III, Spain.
    Background: Non-alcoholic fatty liver disease (NAFLD) has been proposed as an independent cardiovascular risk factor. This study evaluated the prevalence of NAFLD in a cohort of Type 1 Diabetic (T1D) patients and its potential relationship with subclinical cardiovascular disease (CVD).

    Methods: Cross-sectional study in which 100 T1D patients (39. Read More

    Bullous pemphigoid arising in a patient with acquired perforating dermatosis.
    Clin Exp Dermatol 2017 Feb 20. Epub 2017 Feb 20.
    Department of Dermatology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan.
    A middle-aged Japanese man who had been on haemodialysis treatment for diabetic nephropathy developed multiple itchy papules and nodules, which were histopathologically diagnosed as acquired perforating dermatosis. Two years later he developed oral lesions and subsequently numerous erosive plaques with necrotic crusts on the trunk and extremities. Histopathology of a papule showed a parakeratotic plug intermingled with basophilic, necrotic debris and collagen bundles, along with penetration of collagen bundles across the epidermis and subepidermal blister. Read More

    The association between macronutrient intake and the metabolic syndrome and its components in type 1 diabetes.
    Br J Nutr 2017 Feb 20:1-7. Epub 2017 Feb 20.
    1Folkhälsan Research Center,Folkhälsan Institute of Genetics,00290 Helsinki,Finland.
    Diet is a major modifiable lifestyle factor that may affect the components of the metabolic syndrome. We aimed to investigate the association between relative proportions of macronutrients and the components of the metabolic syndrome in a population of individuals with type 1 diabetes. In all, 791 individuals without nephropathy, with plausible energy intake and known metabolic syndrome status, taking part in the Finnish Diabetic Nephropathy Study were included in the analyses. Read More

    Seaweed polysaccharides - New therapeutic insights against the inflammatory response in diabetic nephropathy.
    Antiinflamm Antiallergy Agents Med Chem 2017 Feb 16. Epub 2017 Feb 16.
    Renal Research Lab, Centre for biomedical Research, School of Biosciences and Technology, VIT University, Vellore, India.
    Background: The higher risk of diabetic nephropathy (DN) leads to end stage renal diseases in worldwide, which is associated with chronic inflammation. Currently, the available treatments are limited, lack of efficacy and safety. Therefore, we are in need of novel targets and advanced treatments to reduce the necessity for the renal replacement therapy and burden of this disease management. Read More

    Avocado oil induces long-term alleviation of oxidative damage in kidney mitochondria from type 2 diabetic rats by improving glutathione status.
    J Bioenerg Biomembr 2017 Feb 18. Epub 2017 Feb 18.
    Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-3, Ciudad Universitaria, Av. Fco. J. Mújica S/N, 58030, Morelia, Mich, México.
    Hyperglycemia and mitochondrial ROS overproduction have been identified as key factors involved in the development of diabetic nephropathy. This has encouraged the search for strategies decreasing glucose levels and long-term improvement of redox status of glutathione, the main antioxidant counteracting mitochondrial damage. Previously, we have shown that avocado oil improves redox status of glutathione in liver and brain mitochondria from streptozotocin-induced diabetic rats; however, the long-term effects of avocado oil and its hypoglycemic effect cannot be evaluated because this model displays low survival and insulin depletion. Read More

    Palmitate Induces Mitochondrial Superoxide Generation and Activates AMPK in Podocytes.
    J Cell Physiol 2017 Feb 18. Epub 2017 Feb 18.
    Renal Pathology Lab, Hankook Kidney and Diabetes Institute, Seoul, Korea.
    Studies have shown that high levels of serum free fatty acids (FFAs) are associated with lipotoxicity and type 2 diabetes. Palmitic acid (PA) is the predominant circulating saturated FFA, yet its role in the pathogenesis of diabetic nephropathy (DN) is not clear. Recently, one study suggested that mitochondrial superoxide production is related to AMP-activated protein kinase (AMPK) activity in diabetic mice kidneys. Read More

    High Glucose-Induced Hypomethylation Promotes Binding of Sp-1 to Myo-Inositol Oxygenase: Implication in the Pathobiology of Diabetic Tubulopathy.
    Am J Pathol 2017 Feb 13. Epub 2017 Feb 13.
    Department of Pathology, Northwestern University, Chicago, Illinois; Department of Medicine, Northwestern University, Chicago, Illinois. Electronic address:
    The catabolic enzyme myo-inositol oxygenase (MIOX) is expressed in proximal tubules and up-regulated in the diabetic state. Previously, we reported its transcriptional and translation regulation by high glucose (HG), osmolytes, and fatty acids. However, its epigenetic regulation is unknown. Read More

    Kidney Transplantation Rates Across Glomerulonephritis Subtypes in the United States.
    Transplantation 2017 Feb 15. Epub 2017 Feb 15.
    1 Division of Nephrology, Stanford University School of Medicine, Palo Alto, CA 2 Selzman Institute for Kidney Health, Section of Nephrology, Baylor College of Medicine, Houston, TX.
    Background: Whether kidney transplantation rates differ by glomerulonephritis (GN) subtype remains largely unknown.

    Methods: Using the US Renal Data System, we identified all adult patients with ESRD attributed to 1 of 6 GN subtypes who initiated dialysis in the US (1996-2013). Patients with diabetic nephropathy (DN) and autosomal-dominant polycystic kidney disease (ADPKD) served as "external" non-GN comparators. Read More

    Accumulation of alpha-fluoro-beta-alanine and fluoro mono acetate in a patient with 5-fluorouracil-associated hyperammonemia.
    Cancer Chemother Pharmacol 2017 Feb 15. Epub 2017 Feb 15.
    Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
    Purpose: High-dose 5-fluorouracil (5-FU) containing chemotherapy occasionally causes hyperammonemia and can be lethal. However, the mechanism of 5FU-associated hyperammonemia has not been known. The aim of this study was to reveal the pharmacokinetics of 5-FU-associated hyperammonemia in a recurrent colorectal cancer patient with end-stage renal disease (ESRD). Read More

    The association between interleukin-19 concentration and diabetic nephropathy.
    BMC Nephrol 2017 Feb 15;18(1):65. Epub 2017 Feb 15.
    Department of Clinical Laboratory, Binhai County Hospital, Binhai, Jiangsu Province, China.
    Background: Interleukin-19 (IL-19) is a newly discovered cytokine belonging to the Interleukin-10(IL-10) family. IL-19 have indispensable functions in many inflammatory processes and also can induce the angiogenic potential of endothelial cells. The purpose of present study was to investigate the relation of serum interleukin-19 (IL-19) levels with diabetic nephropathy (DN). Read More

    Common drugs for stabilization of renal function in the progression of diabetic nephropathy and their relations with hypertension therapy.
    Curr Diabetes Rev 2017 Feb 14. Epub 2017 Feb 14.
    Department of Clinical Science, Intervention and Technologies, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
    Diabetic nephropathy is characterized by hypertension, progressive albuminuria, glomerulosclerosis and declines in glomerular filtration rate leading to end stage renal disease. Although the pathogenesis of diabetic nephropathy is not fully understood, current treatment of the patients with diabetic nephropathy is mainly based upon the control of hyperglycaemia and management of blood pressures. Several drugs, which are originally developed for hypertension therapy, have been adopted for stabilization of renal function in diabetic nephropathy. Read More

    Role of HSP60 (HSPD1) in diabetes-induced renal tubular dysfunction: regulation of intracellular protein aggregation, ATP production, and oxidative stress.
    FASEB J 2017 Feb 14. Epub 2017 Feb 14.
    Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand;
    Because underlying mechanisms of diabetic nephropathy/tubulopathy remained poorly understood, we aimed to define a key protein involving in hyperglycemia-induced renal tubular dysfunction. All altered renal proteins identified from previous large-scale proteome studies were subjected to global protein network analysis, which revealed heat shock protein 60 (HSP60, also known as HSPD1) as the central node of protein-protein interactions. Functional validation was performed using small interfering RNA (siRNA) to knock down HSP60 (siHSP60). Read More

    SGLT2 Expression is increased in Human Diabetic Nephropathy: SGLT2 Inhibition Decreases Renal Lipid Accumulation, Inflammation and the Development of Nephropathy in Diabetic Mice.
    J Biol Chem 2017 Feb 14. Epub 2017 Feb 14.
    University of Colorado Denver; VA Medical Center, United States
    There is very limited human renal sodium gradient dependent glucose transporter protein SGLT2 mRNA and protein expression data reported in the literature. Aim 1 of this study was to determine SGLT2 mRNA and protein levels in human and animal models of diabetic nephropathy. We have found that the expression of SGLT2 mRNA and protein is increased in renal biopsies from human subjects with diabetic nephropathy. Read More

    Diabetes Control and the Risks of ESRD and Mortality in Patients With CKD.
    Am J Kidney Dis 2017 Feb 10. Epub 2017 Feb 10.
    Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH.
    Background: Diabetes is the leading cause of end-stage renal disease (ESRD) and a significant contributor to mortality in the general population. We examined the associations of hemoglobin A1c (HbA1c) levels with ESRD and death in a population with diabetes and chronic kidney disease (CKD).

    Study Design: Cohort study. Read More

    [Diagnosis and treatment of chronic kidney disease].
    Internist (Berl) 2017 Feb 13. Epub 2017 Feb 13.
    Klinik für Innere Medizin II, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06120, Halle (Saale), Deutschland.
    Chronic kidney disease is defined by decreased glomerular filtration rate or proteinuria. Diabetic nephropathy and hypertensive renal damage are responsible for the majority of cases. The initiation of therapy has to consider if causal treatment of the underlying disease is possible and indicated. Read More

    Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling.
    Biomed Res Int 2017 17;2017:1516985. Epub 2017 Jan 17.
    Department of Nephrology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, China.
    Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, partly because of the lack of effective treatments for DN. Curcumin has been shown to exert strong antifibrotic effects in DN, but the underlying mechanisms are not well characterized. In this study, we sought to determine the effects of curcumin on diabetic renal disease in db/db mice and characterize the underlying mechanism of action. Read More

    Impaired myogenic response of the afferent arteriole contributes to the increased susceptibility to renal disease in Milan normotensive rats.
    Physiol Rep 2017 Feb;5(3)
    Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi
    Milan normotensive (MNS) rats are more susceptible to the development of renal disease than Milan hypertensive (MHS) rats, but the genes and pathways involved are unknown. This study compared the myogenic response of isolated perfused afferent arterioles (Af-Art) and autoregulation of renal blood flow (RBF) and glomerular capillary pressure (Pgc) in 6-9-week-old MNS and MHS rats. The diameter of the Af-Art of MHS rats decreased significantly from 14. Read More

    Hydrogen Sulfide Inhibits High Glucose-induced NADPH Oxidase 4 Expression and Matrix Increment by Recruiting Inducible Nitric Oxide Synthase in the Kidney Proximal Tubular Epithelial Cells.
    J Biol Chem 2017 Feb 10. Epub 2017 Feb 10.
    University of Texas Health Science Center at San Antonio, United States
    High glucose increases NADPH oxidase 4 (NOX4) expression, reactive oxygen species (ROS) generation, and, matrix protein synthesis by inhibiting AMP-activated protein kinase (AMPK) in renal cells. Since hydrogen sulfide (H2S) inhibits high glucose-induced matrix protein increment by activating AMPK in renal cells, we examined if H2S inhibits high glucose induced expression of NOX4 and matrix protein and if H2S nitric oxide (NO) pathways are integrated. High glucose increased NOX4 expression and activity at 24 h in renal proximal tubular epithelial cells that was inhibited by sodium hydrosulfide (NaHS), a source of H2S. Read More

    Intensified multifactorial intervention in type 2 diabetics with microalbuminuria leads to long-term renal benefits.
    Kidney Int 2017 Feb 7. Epub 2017 Feb 7.
    Novo Nordisk Foundation Center for Basic Metabolic Research, Copenhagen, Denmark. Electronic address:
    In the present post hoc analyses we studied the impact of intensified, multifactorial treatment on renal outcomes in patients with type 2 diabetes and microalbuminuria enrolled in the Steno-2 Study. Outcome measures were progression to macroalbuminuria, decline in the glomerular filtration rate (GFR), and development of end stage renal disease (ESRD). In total, 160 patients with type 2 diabetes and microalbuminuria were recruited and assigned to conventional or intensified therapy targeting multiple risk factors. Read More

    Case management of patients with Type 2 diabetes mellitus: a cross-sectional survey in Chongqing, China.
    BMC Health Serv Res 2017 Feb 11;17(1):129. Epub 2017 Feb 11.
    Duke Global Health Institute, Duke University, Durham, NC, USA.
    Background: Type 2 diabetes mellitus has been identified as one of the priority diseases and included in the essential public health service package in China. This study investigated the frequency of follow-up visits and contents of care for case management of patients with Type 2 diabetes in Chongqing located in the western China, in terms of the regional practice guideline; and analyzed factors associated with the use of care.

    Methods: A cross-sectional survey was conducted with patients diagnosed with Type 2 diabetes in two areas in Chongqing. Read More

    Novel insights into DNA methylation and its critical implications in diabetic vascular complications.
    Biosci Rep 2017 Feb 9. Epub 2017 Feb 9.
    Peking Union Medical College Hospital, Beijing, Massachusetts, 100730, China
    Recent epidemiological and clinical studies have shown that type 2 diabetic patients can develop diabetic vascular complications even after intensive glycemic control. It has been suggested that this phenomenon could be explained by the hypothesis of "metabolic memory". The underlying mechanisms between these enduring effects and the prior hyperglycemic state are still not well understood. Read More

    Diabetic nephropathy: A potential savior with 'rotten-egg' smell.
    Pharmacol Rep 2016 Nov 11;69(2):331-339. Epub 2016 Nov 11.
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Electronic address:
    Diabetic nephropathy (DN) is currently the leading cause of end-stage renal disease. Despite optimal management, DN is still a major contributor to morbidity and mortality of diabetic patients worldwide. The major pathological alterations in DN include excessive accumulation and deposition of extracellular matrix, leading to expansion of mesangial matrix, thickening of glomerular basement membrane and tubulointerstitial fibrosis. Read More

    Tangshen formula attenuates diabetic renal injuries by upregulating autophagy via inhibition of PLZF expression.
    PLoS One 2017 9;12(2):e0171475. Epub 2017 Feb 9.
    Beijing Key Lab Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
    The Chinese herbal granule Tangshen Formula (TSF) has been proven to decrease proteinuria and improve estimated glomerular filtration rate (eGFR) in diabetic kidney disease (DKD) patients. However, the underlying mechanism of TSF on treatment of diabetic nephropathy (DN) remains unclear. The present study aimed to identify the therapeutic target of TSF in diabetic renal injuries through microarray-based gene expression profiling and establish its underlying mechanism. Read More

    Nephropathy in Pparg-null mice highlights PPARγ systemic activities in metabolism and in the immune system.
    PLoS One 2017 9;12(2):e0171474. Epub 2017 Feb 9.
    Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
    Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-dependent transcription factor involved in many aspects of metabolism, immune response, and development. Total-body deletion of the two Pparg alleles provoked generalized lipoatrophy along with severe type 2 diabetes. Herein, we explore the appearance and development of structural and functional alterations of the kidney, comparing Pparg null-mice to their littermate controls (carrying Pparg floxed alleles). Read More

    Clinical Implication of Cystatin C and β2-Microglobulin in Early Detection of Diabetic Nephropathy.
    Clin Lab 2017 Feb;63(2):241-247
    Background: Diabetic nephropathy (DN) is one of the major late complications of type 2 diabetes mellitus (T2DM). The aim of this study was to evaluate the efficiency of cystatin C (cysC) and β2-microglobulin (β2-MG) in diagnosing early DN and to identify the optimal threshold in the Chinese patients.

    Methods: T2DM patients were divided into 102 non-DN subjects, 60 early DN subjects, and 38 clinical DN subjects. Read More

    Maresin 1 Mitigates High Glucose-Induced Mouse Glomerular Mesangial Cell Injury by Inhibiting Inflammation and Fibrosis.
    Mediators Inflamm 2017 15;2017:2438247. Epub 2017 Jan 15.
    Endocrinology Department, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
    Background. Inflammation and fibrosis are the important pathophysiologic processes in diabetic nephropathy (DN). Maresin 1 is a potential anti-inflammatory lipid mediator, which has displayed powerful proresolving activities. Read More

    Biomarker response to contrast administration in diabetic and nondiabetic patients following coronary angiography.
    Indian J Nephrol 2017 Jan-Feb;27(1):20-27
    Department of Biochemistry, S.V. Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
    Neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C represent early renal injury markers for contrast-induced nephropathy (CIN). Baseline parameters such as type and quantity of contrast, patient preparation, renal function status, and diabetes mellitus (DM) are known to affect the response of the kidney to contrast-induced injury. This study was taken up to know the biomarker response to contrast administration in 58 diabetic and 59 nondiabetic male patients with same baseline parameters and baseline serum creatinine <1. Read More

    Hemodialysis outcomes and practice patterns in end-stage renal disease: Experience from a Tertiary Care Hospital in Kerala.
    Indian J Nephrol 2017 Jan-Feb;27(1):51-57
    Senior Consultant, Nephrology, CoE Nephrology and Urology, Aster Medicity, Kochi, Kerala, India.
    This study was planned to analyze the hemodialysis practice patterns from a tertiary care referral centre as there is very limited data from India. All patients of ESRD on maintenance hemodialysis (MHD) in dialysis unit at AIMS, Kochi, Kerala for a minimum period of 3 months were included. A total of 134 patients (M: F 2:1) with age of 20 to 84 years (Mean: 59. Read More

    Calcium Uptake via Mitochondrial Uniporter Contributes to Palmitic Acid-induced Apoptosis in Mouse Podocytes.
    J Cell Biochem 2017 Feb 9. Epub 2017 Feb 9.
    Laboratory of Renal Disease, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, P.R. China.
    Podocytes are component cells of the glomerular filtration barrier, and their loss by apoptosis is the main cause of proteinuria that leads to diabetic nephropathy (DN). Therefore, insights into podocyte apoptosis mechanism would allow a better understanding of DN pathogenesis and thus help develop adequate therapeutic strategies. Here, we investigated the molecular mechanism of palmitic acid-inhibited cell death in mouse podocytes, and found that palmitic acid increased cell death in a dose- and time-dependent manner. Read More

    Circulating levels of fibroblast growth factor 21 in early-stage diabetic kidney disease.
    Ir J Med Sci 2017 Feb 8. Epub 2017 Feb 8.
    Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, PO Box 13145-784, Tehran, Iran.
    Aims/purpose: Fibroblast growth factor 21 (FGF21), a hepatoadipokine with pleiotropic metabolic regulatory actions, is emerging as a novel biomarker of progressive nephropathy. We sought to evaluate circulating FGF21 and its association with clinical and biochemical characteristics as well as the urinary albumin excretion (UAE) rates in a population of patients with type 2 diabetes (T2D) with or without microalbuminuria and their matched healthy controls.

    Methods: Cross-sectionally, 130 consecutive individuals comprising patients with T2D with (n = 44) or without (n = 44) microalbuminuria and their healthy controls (n = 42) were recruited for analysis. Read More

    Association between poor psychosocial conditions and diabetic nephropathy in Japanese type 2 diabetes patients: a cross-sectional study.
    J Diabetes Investig 2017 Feb 8. Epub 2017 Feb 8.
    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
    Aims/introduction: It is suggested that positive psychosocial condition has a good effect on health and glycemic control. However, there has been no research to evaluate the association between positive psychosocial factors and diabetic nephropathy (DN). The aim of this study was to evaluate the association between psychosocial factors and DN in patients with type 2 diabetes. Read More

    Enhanced expression of two discrete isoforms of matrix metalloproteinase-2 in experimental and human diabetic nephropathy.
    PLoS One 2017 8;12(2):e0171625. Epub 2017 Feb 8.
    Biomedical Research Institute and Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea.
    Background: We recently reported on the enhanced expression of two isoforms of matrix metalloproteinase-2 (MMP-2) in human renal transplantation delayed graft function. These consist of the conventional secreted, full length MMP-2 isoform (FL-MMP-2) and a novel intracellular N-Terminal Truncated isoform (NTT-MMP-2) generated by oxidative stress-mediated activation of an alternate promoter in the MMP-2 first intron. Here we evaluated the effect of hyperglycemia and diabetes mellitus on the in vitro and in vivo expression of the two MMP-2 isoforms. Read More

    Is the Proportion of Carbohydrate Intake Associated with the Incidence of Diabetes Complications?-An Analysis of the Japan Diabetes Complications Study.
    Nutrients 2017 Feb 6;9(2). Epub 2017 Feb 6.
    Department of Hematology, Endocrinology and Metabolism, Niigata University Faculty of Medicine, Niigata 951-8510, Japan.
    The appropriate proportions of macronutritional intake have been controversial in medical nutritional therapy for diabetes, and evidence of the effects of carbohydrate consumption on diabetes complications in prospective settings is sparse. We investigated the relationships between proportions of carbohydrate intake as the % of total energy and diabetes complications in a nationwide cohort of Japanese patients with type 2 diabetes aged 40-70 years with hemoglobin A1c ≥6.5%. Read More

    Sodium glucose co-transporter 2 inhibitors and their nephroprotective potential
.
    Clin Nephrol 2017 Feb 8. Epub 2017 Feb 8.
    Chronic kidney disease among patients with diabetes is on the rise. The sodium glucose co-transporters 2 inhibitors are a new class of glucose-lowering agents, which act through a novel mechanism by producing a decline in glucose reabsorption in the kidney, thereby increasing glucosuria and decreasing serum glucose levels. Data suggest that they possess nephroprotective properties. Read More

    End-stage renal disease and adherence to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers among patients with diabetes.
    J Clin Hypertens (Greenwich) 2017 Feb 8. Epub 2017 Feb 8.
    Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel.
    Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have become standards of care for diabetic nephropathy. The authors assessed the association between treatment adherence to ACEIs and ARBs and the development of end-stage renal disease (ESRD). The cohort comprised the 9895 members of the Central District of Clalit Health Services aged 40 to 70 years, diagnosed with diabetes before 2002, who filled at least four ACEI or ARB monthly prescriptions during 2002-2011. Read More

    Kidney Function Improvement by Soy Milk Containing Lactobacillus plantarum A7 in Type 2 Diabetic Patients With Nephropathy: a Double-Blinded Randomized Controlled Trial.
    Iran J Kidney Dis 2017 01;11(1):36-43
    Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
    Introduction: Even with the ultimate medical management, more than one-third of diabetic patients develop diabetic nephropathy. To our knowledge, there is no study that has examined the effect of probiotic soy milk on kidney function in type 2 diabetic patients with nephropathy. This clinical trial aimed to assess the effects of consumption of probiotic soy milk, compared with conventional soy milk, on kidney-related indexes in patients with diabetic nephropathy. Read More

    Endothelial Colony Forming Cells (ECFCs) in murine AKI - implications for future cell-based therapies.
    BMC Nephrol 2017 Feb 6;18(1):53. Epub 2017 Feb 6.
    Clinic of Nephrology and Rheumatology, University Medicine Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany.
    Background: In recent years, early Endothelial Progenitor Cells (eEPCs) have been proven as effective tool in murine ischemic AKI and in diabetic nephropathy. The mechanisms of eEPC-mediated vasoprotection have been elucidated in detail. Besides producing a diverse range of humoral factors, the cells also act by secreting vasomodulatory microvesicles. Read More

    APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury.
    Lab Invest 2017 Feb 6. Epub 2017 Feb 6.
    Department of Internal Medicine, Division of Nephrology, Korea University Ansan Hospital, Ansan, Korea.
    Recent studies have suggested that renal Nox is important in the progression of diabetic nephropathy. Therefore, we investigated the effect of a novel pan-NOX-inhibitor, APX-115, on diabetic nephropathy in type 2 diabetic mice. Eight- week-old db/m and db/db mice were treated with APX-115 for 12 weeks. Read More

    Tangzhiqing Granules Alleviate Podocyte Epithelial-Mesenchymal Transition in Kidney of Diabetic Rats.
    Evid Based Complement Alternat Med 2017 10;2017:1479136. Epub 2017 Jan 10.
    The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China.
    This study discussed the effect of Tangzhiqing granules on podocyte epithelial-mesenchymal transition in kidney of diabetic rats. The diabetic rats were divided randomly into five groups: DM group treated with vehicle, Tangzhiqing granules low-dose treatment group, Tangzhiqing granules middle-dose treatment group, and Tangzhiqing granules high-dose treatment group. Eight Wistar rats used as control group were given saline solution. Read More

    Prevalence of microalbuminuria and its correlates among diabetic patients attending diabetic clinic at National Guard Hospital in Alhasa.
    J Family Community Med 2017 Jan-Apr;24(1):1-5
    Diabetic Clinic, Primary Health Center, King Abdulaziz Hospital (NGHA), Al-Ahsa, Kingdom of Saudi Arabia.
    Introduction: Diabetes mellitus is one of the most common diseases encountered in clinical practice. Diabetic nephropathy is a common consequence of long-standing diabetes mellitus; microalbuminuria (MA) is considered an early stage of diabetic nephropathy.

    Objectives: To determine the prevalence of miciroalbuminuria in diabetic patients and factors associated with MA. Read More

    Hypertension influences the exponential progression of inflammation and oxidative stress in streptozotocin-induced diabetic kidney.
    J Pharmacol Pharmacother 2016 Oct-Dec;7(4):159-164
    Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
    Objective: To investigate the association of hypertension coexisting with diabetes mellitus with oxidative stress and inflammation in the kidneys of streptozotocin (STZ)-induced diabetic rats.

    Materials And Methods: Male Wistar rats were used for the experiments. Blood glucose (BG), urea, blood pressure (BP), and heart rate (HR) were analyzed before and 48 h after STZ injection. Read More

    The Increased Transforming Growth Factor-β Signaling Induced by Diabetes Protects Retinal Vessels.
    Am J Pathol 2017 Mar 2;187(3):627-638. Epub 2017 Feb 2.
    Schepens Eye Research Institute, Massachusetts Eye and Ear, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts. Electronic address:
    The roles of transforming growth factor (TGF)-β in extracellular matrix production and vascular remodeling, coupled with increased TGF-β expression and signaling in diabetes, suggest TGF-β as an important contributor to the microangiopathy of diabetic retinopathy and nephropathy. To investigate whether increased TGF-β signaling could be a therapeutic target for preventing retinopathy, we used a pharmacologic approach (SM16, a selective inhibitor of the type 1 TGF-β receptor activin receptor-like kinase 5, orally active) to inhibit the increased, but not the basal, Tgf-β signaling in retinal vessels of diabetic rats. At the level of vascular gene expression, 3. Read More

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