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    A new model of diabetic nephropathy in C57BL/6 mice challenged with advanced oxidation protein products.
    Free Radic Biol Med 2018 Feb 17. Epub 2018 Feb 17.
    Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangzhou, Guangdong, PR China.
    There remains a lack of robust mouse models with key features of advanced human diabetic nephropathy (DN). Few options of murine models of DN require mutations to be superimposed to obtain desired phenotypic characteristics. Most genetically modified mice are on the C57BL/6 background; however, they are notorious for resistance to develop DN. Read More

    Adiponectin Receptor Agonist AdipoRon Decreased Ceramide, and Lipotoxicity, and Ameliorated Diabetic Nephropathy.
    Metabolism 2018 Feb 17. Epub 2018 Feb 17.
    Division of Nephrology, Department of Internal Medicine, Anyang, Republic of Korea; Institute for Aging and Metabolic Diseases, College of Medicine, the Catholic University of Korea, Seoul, Republic of Korea. Electronic address:
    Background: Adiponectin is known to take part in the regulation of energy metabolism. AdipoRon, an orally-active synthetic adiponectin agonist, binds to both adiponectin receptors (AdipoR)1/R2 and ameliorates diabetic complications. Among the lipid metabolites, the ceramide subspecies of sphingolipids have been linked to features of lipotoxicity, including inflammation, cell death, and insulin resistance. Read More

    The relationship between hemoglobin level and the type 1 diabetic nephropathy in Anhui Han's patients.
    Intern Med J 2018 Feb 20. Epub 2018 Feb 20.
    Department of Nephrology, Anhui Provincal Hospital, Anhui Medical University, No 17 Lujiang Road, Hefei, 230001, China.
    Background: Recent studies have shown that low hemoglobin (Hb) level promote the progression of chronic kidney disease. This study assessed the relationship between Hb level and type 1 diabetic nephropathy (DN) in Anhui Han's patients.

    Methods: There were a total of 236 patients diagnosed with type 1 diabetes mellitus and (T1DM) seen between January 2014 and December 2016 in our centre. Read More

    Effect of Sleep-Disordered Breathing on Albuminuria in 273 Patients With Type 2 Diabetes.
    J Clin Sleep Med 2018 Feb 13. Epub 2018 Feb 13.
    Study Objectives: Sleep-disordered breathing (SDB) can induce hyperglycemia, hypertension, and oxidative stress, conditions that are known to cause kidney damage. Therefore, SDB may exacerbate albuminuria, which is an established marker of early-stage kidney damage in patients with type 2 diabetes mellitus (T2DM). The association between SDB and albuminuria in patients with T2DM was investigated in this study. Read More

    FGF 23, PTH and vitamin D status in end stage renal disease patients affected by VDR FokI and BsmI variants.
    Clin Biochem 2018 Feb 16. Epub 2018 Feb 16.
    Immuno-Rheumatology Research Laboratory, Rheumatology Department, La Rabta Hospital, University of Tunis-El Manar, Tunis, Tunisia; Laboratory of Clinical Biochemistry and Hormonology, Pasteur Institute of Tunis, Tunis El Manar University, Tunisia.
    Objectives: The aim of this study was to evaluate the association between two VDR SNPs FokI and BsmI and mineral status in ESRD patients.

    Design And Methods: Our case-control study included 100 patients with chronic renal failure in ESRD and 149 healthy subjects. We measured the serum Vitamin D levels and the serum intact PTH level by Electrochemiluminescence Technology (cobas E411 analyzer). Read More

    Importance of renal biopsy in patients aged 60 years and older: Experience from a tertiary care hospital.
    Saudi J Kidney Dis Transpl 2018 Jan-Feb;29(1):140-144
    Department of Nephrology, Sir Ganga Ram Hospital, New Delhi, India.
    As the life expectancy is increasing, there is a rise in elderly population and consequent increase in the patients with renal disease. There is an inconsistency between clinical and histopathological diagnosis in elderly, and so renal biopsy is important in these patients to decide appropriate clinical management and prognosis. This study outlines the importance of renal biopsy in elderly and describes the clinical and pathologic spectrum of renal diseases in patient ≥60 years. Read More

    Medical renal disease in tumor nephrectomies: The silent killer.
    Saudi J Kidney Dis Transpl 2018 Jan-Feb;29(1):50-56
    Department of Pathology, Armed Forces Medical College, Pune, Maharashtra, India.
    In tumor nephrectomy specimens, the evaluation of the normal renal parenchyma is often overlooked. A patient with both end-stage renal diseases (ESRDs) with a renal cell carcinoma is more likely to die of the ESRD rather than cancer. At the time of nephrectomy, a pathologist has a large amount of tissue available to him to comment upon the presence of disease in the nonneoplastic kidney. Read More

    Taxus chinensis ameliorates diabetic nephropathy through down-regulating TGF-β1/Smad pathway.
    Chin J Nat Med 2018 Feb;16(2):90-96
    Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address:
    Diabetic nephropathy (DN) is one of the common microvascular complications of diabetes mellitus. Renal fibrosis is closely related to the deterioration of renal function. The present study aimed to investigate protective effect of Taxus chinensis on high-fat diet/streptozotocin-induced DN in rats and explore the underlying mechanism of action. Read More

    Renal fat fraction and diffusion tensor imaging in patients with early-stage diabetic nephropathy.
    Eur Radiol 2018 Feb 15. Epub 2018 Feb 15.
    Department of Radiology, Zhongda Hospital, Jiangsu Key Laboratory of Molecular and Functional Imaging, Zhongda Hospital, Medical School of Southeast University, 87 Ding Jia Qiao Road, Nanjing, 210009, China.
    Objective: To investigate the renal fat fraction and water molecular diffusion features in patients with early-stage DN using Dixon imaging and diffusion tensor imaging (DTI).

    Methods: Sixty-one type 2 diabetics (normoalbuminuria: n = 40; microalbuminuria: n = 21) and 34 non-diabetic volunteers were included. All participants received three-point Dixon imaging and DTI using a 3. Read More

    HDAC6 Inhibition Promotes Transcription Factor EB Activation and Is Protective in Experimental Kidney Disease.
    Front Pharmacol 2018 1;9:34. Epub 2018 Feb 1.
    Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
    To contend with the deleterious effects of accumulating misfolded protein aggregates or damaged organelles cells rely on a system of quality control processes, among them the autophagy-lysosome pathway. This pathway is itself controlled by a master regulator transcription factor termed transcription factor EB (TFEB). When TFEB localizes to the cell nucleus it promotes the expression of a number of genes involved in protein clearance. Read More

    Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy.
    Cell Death Dis 2018 Feb 15;9(3):270. Epub 2018 Feb 15.
    Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
    Apoptosis and autophagy are harmoniously regulated biological processes for maintaining tissue homeostasis. AMP-activated protein kinase (AMPK) functions as a metabolic sensor to coordinate cellular survival and function in various organs, including the kidney. We investigated the renoprotective effects of cinacalcet in high-glucose treated human glomerular endothelial cells (HGECs), murine podocytes and C57BLKS/J-db/db mice. Read More

    RAGE Deletion Confers Renoprotection by Reducing Responsiveness to Transforming Growth Factor-β and Increasing Resistance to Apoptosis.
    Diabetes 2018 Feb 15. Epub 2018 Feb 15.
    Department of Diabetes, Monash University, Melbourne, Australia.
    Signalling via the receptor of advanced glycation end-products (RAGE) although complex and not fully elucidated in the setting of diabetes, is considered a key injurious pathway in the development of diabetic nephropathy (DN). We report here that RAGE deletion resulted in increased expression of fibrotic (collagen I and IV, fibronectin) and the inflammatory marker, MCP-1 in primary mouse mesangial cells (MC) and in kidney cortex. RNA-seq analysis in MCs from RAGEand wild type mice confirmed these observations. Read More

    CX3CL1/CX3CR1 axis, as The Therapeutic Potential In Renal Diseases: Friend Or Foe?
    Curr Gene Ther 2018 Feb 13. Epub 2018 Feb 13.
    Transplantation Center of the 3rd Xiangya Hospital, Central South University, Changsha, Hunan 410013. China.
    The fractalkine receptor chemokine (C-X3-C motif) receptor 1 (CX3CR1) and its highly selective ligand CX3CL1 mediate chemotaxis and adhesion of immune cells, which are involved in the pathogenesis and progression of numerous inflammatory disorders and malignancies. The CX3CL1/CX3CR1 axis has recently drawn attention as a potential therapeutic target because it is involved in the ontogeny, homeostatic migration, or colonization of renal phagocytes. We performed a Medline/PubMed search to detect recently published studies that explored the relationship between the CX3CL1/CX3CR1 axis and renal diseases and disorders, including diabetic nephropathy, renal allograft rejection, infectious renal diseases, IgA nephropathy, fibrotic kidney disease, lupus nephritis and glomerulonephritis, acute kidney injury and renal carcinoma. Read More

    Vitamin D receptor: A novel therapeutic target for kidney diseases.
    Curr Med Chem 2018 Feb 14. Epub 2018 Feb 14.
    Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan. China.
    Background: Kidney disease is a serious problem that adversely affects human health, but critical knowledge is lacking on how to effectively treat established chronic kidney disease. Mounting evidence from animal and clinical studies has suggested that vitamin D receptor (VDR) activation has beneficial effects on various renal diseases.

    Method: A structured search of published research literature regarding VDR structure and function, VDR in various renal diseases (e. Read More

    Gender Difference in the Association of Early- vs. Late-Onset Type 2 Diabetes with Non-Fatal Microvascular Disease in China: A Cross-sectional Study.
    Front Endocrinol (Lausanne) 2018 31;9:15. Epub 2018 Jan 31.
    Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.
    Background: This study aimed to test whether early-onset (defined as <40 years of age) type 2 diabetes mellitus (T2DM) imparted different risks of microvascular disease to Chinese men and women.

    Methods: 222,537 Chinese patients with T2DM were recruited in 630 hospitals from 106 cities in 30 provinces of China in 2012 using a cross-sectional design. Logistic regression analysis was performed to obtain odds ratios (ORs) of male vs. Read More

    Mangiferin prevents diabetic nephropathy progression and protects podocyte function via autophagy in diabetic rat glomeruli.
    Eur J Pharmacol 2018 Feb 11. Epub 2018 Feb 11.
    Biomedical Engineering Research Center, Kunming Medical University, Kunming 650500, China. Electronic address:
    Diabetic nephropathy (DN) is one of the most severe microangiopathies of diabetes mellitus and is a leading cause of end stage renal disease. Numerous studies suggest that podocyte injury contributes to progressive proteinuria. Podocytes are highly specialized, terminally differentiated cells that are unable to proliferate, autophagy plays a key role in maintaining the structure and function of podocytes. Read More

    Adiposity Impacts Intrarenal Hemodynamic Function in Adults With Long-standing Type 1 Diabetes With and Without Diabetic Nephropathy: Results From the Canadian Study of Longevity in Type 1 Diabetes.
    Diabetes Care 2018 Feb 2. Epub 2018 Feb 2.
    Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
    Objective: Central adiposity is considered to be an important cardiorenal risk factor in the general population and in type 1 diabetes. We sought to determine the relationship between central adiposity and intrarenal hemodynamic function in adults with long-standing type 1 diabetes with and without diabetic nephropathy (DN).

    Research Design And Methods: Patients with type 1 diabetes (= 66, duration ≥50 years) and age-/sex-matched control subjects (= 73) were studied. Read More

    Concomitant administration of resveratrol and insulin protects against diabetes mellitus type-1-induced renal damage and impaired function via an antioxidant-mediated mechanism and up-regulation of Na/K-ATPase.
    Arch Physiol Biochem 2018 Feb 13:1-10. Epub 2018 Feb 13.
    a Department of Physiology, College of Medicine , King Khalid University , Abha , Saudi Arabia.
    This study investigated if a combination of resveratrol (RES) and insulin could reverse type 1 diabetic mellitus-induced (T1DM) nephropathy and illustrates mechanism of action. Rats were divided into six groups (n = 10/group) as follows: control, control + RES (20 mg/kg), T1DM, T1DM + RES, T1DM + insulin (1 U/g), and T1DM + RES + insulin and treated for eight weeks. While individual administrations of both drugs significantly but partially restored renal function and cortex architectures, combination therapy of both RES and insulin produced the maximum improvements. Read More

    Highglucose induces podocyteepithelial‑to‑mesenchymal transition by demethylation‑mediated enhancement of mmp9 expression.
    Mol Med Rep 2018 Feb 2. Epub 2018 Feb 2.
    Department of Endocrinology, Guangdong Medical College Affiliated Shenzhen Nanshan Hospital, Shenzhen, Guangdong 518052, P.R. China.
    Abnormal expression of matrix metalloproteinase 9 (MMP9) is correlated with podocyte epithelial-to---mesenchymal transition (EMT) in diabetic nephropathy (DN). However, the mechanisms underlying this process are not well defined. Site‑specific demethylation may sustain high expression levels of target genes. Read More

    Long noncoding RNA ENSRNOG00000037522 is involved in the podocyte epithelial‑mesenchymal transition in diabetic rats.
    Int J Mol Med 2018 Feb 5. Epub 2018 Feb 5.
    Department of Endocrinology, Guangdong Medical College Affiliated Shenzhen Nanshan Hospital, Shenzhen, Guangdong 518052, P.R. China.
    Diabetic nephropathy (DN) is one of the most common complications associated with type I and II diabetes mellitus. Long noncoding RNAs (lncRNAs) have been implicated in various physiological and pathological processes, and recent evidence has demonstrated that they are involved in the process of the epithelial‑mesenchymal transition (EMT). In the present study, the potential functions of lncRNA ENSRNOG00000037522 during the EMT process in DN were investigated. Read More

    Tangshen formula improves inflammation in renal tissue of diabetic nephropathy through SIRT1/NF-κB pathway.
    Exp Ther Med 2018 Feb 12;15(2):2156-2164. Epub 2017 Dec 12.
    National Traditional Chinese Medicine Clinical Research Center, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China.
    The present study investigated the mechanism underlying the anti-inflammatory effects of Tangshen formula (TS) in Sprague Dawley (SD) rats with diabetic nephropathy (DN). A rat model of DN was established by intraperitoneal injection of 1% (40 mg/kg) streptozotocin and administration of a high fat and glucose diet. Subsequently, SD rats were randomly divided into six groups (n=8): A DN group, a valsartan group, a high-dose TS group, a middle-dose TS group, a low-dose TS group and a control group with normal SD rats. Read More

    Nephroprotective effects of diacylglycerol on diabetic nephropathy in type 2 diabetic rats.
    Exp Ther Med 2018 Feb 18;15(2):1918-1926. Epub 2017 Dec 18.
    Institute of Agro-Food Science and Technology, Shandong Academy of Agricultural Science/Shandong Provincial Key Laboratory of Agricultural Products Deep Processing, Jinan, Shandong 250100, P.R. China.
    Diacylglycerol (DAG) has been reported to reduce the serum lipid and glucose levels more effectively compared with triacylglycerol (TAG). The present study examined the long-term effects of dietary DAG on rats with type 2 diabetic nephropathy (DN). The type 2 DN model was established by administering a high-fat and high-calorie diet along with an intraperitoneal injection of 35 mg/kg body weight streptozocin, and the disease developed over the following 8 weeks. Read More

    Bioactive phytochemicals that regulate the cellular processes involved in diabetic nephropathy.
    Phytomedicine 2018 Jan 18;39:146-159. Epub 2017 Dec 18.
    Gachon Institute of Pharmaceutical Science, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Republic of Korea; Department of Pharmacognosy, College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Republic of Korea. Electronic address:
    Background: Owing to the multiple causative factors, the current advances in medication for diabetic nephropathy (DN) do not appear to have improved therapies for patients. Furthermore, use of multiple synthetic medications has shown various adverse effects and ultimately leads to deterioration of the condition. Medicinal plants and their bioactive constituents are considered to be safer and more effective than synthetic medicines against various chronic diseases. Read More

    The impact of insulin pump therapy to oxidative stress in patients with diabetic nephropathy.
    Eur J Med Res 2018 Feb 12;23(1). Epub 2018 Feb 12.
    Department of Endocrinology, PLA Army General Hospital, Beijing, China.
    Background: The oxidative stress resulting from increased production of ROS plays a crucial role in the development of diabetic complications. We aim to explore the relationships between oxidative stress, diabetic nephropathy (DN) and short-term insulin pump intensive therapy (insulin therapy).

    Methods: Levels of 8-hydroxy-deoxyguanosine (8-OHdG), 3-nitrotyrosine (3-NT), glutathione (GSH), superoxide dismutase (SOD) and Interleukin-6 (IL-6) were estimated before and after 2 weeks of insulin therapy in normal group (NC) and type 2 diabetic (DM) with normal albuminuria (NA), microalbuminuria (MA) and clinical albuminuria (CA). Read More

    [Assessment of renal function with intravoxel incoherent motion and diffusion tensor imaging in type 2 diabetic patients].
    Zhonghua Yi Xue Za Zhi 2018 Jan;98(5):346-351
    Medical School of Southeast University, Nanjing 210009, China.
    To evaluate the application value of intravoxel incoherent motion (IVIM) and diffusion tensor imaging (DTI) in detecting early-stage diabetic nephropathy and to assess the damage of ralated renal function.A total of 52 patients with type 2 diabetes diagnosed in Zhongda Hospital were collected from April 2016 to May 2017 and were assigned to DM group (diabetes without nephropathy,=32) and DN group (diabetes with nephropathy,=20) according to detection of microalbuminuria, a cohort of healthy recipients were included as control group (=27) in the meantime. All of the subjects underwent IVIM and DTI examination. Read More

    Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome.
    Free Radic Biol Med 2018 Feb 7. Epub 2018 Feb 7.
    King's BHF Centre of Research Excellence, School of Cardiovascular Medicine & Sciences, Faculty of Life Sciences & Medicine, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom. Electronic address:
    Diabetes and cardiometabolic disorders such as hypertension and obesity are major risk factors for the development of cardiovascular disease, with a wealth of evidence suggesting that oxidative stress is linked to the initiation and pathogenesis of these disease processes. With yearly increases in the global incidence of cardiovascular diseases (CVD) and diabetes, numerous studies have focused on characterizing whether upregulating antioxidant defenses through exogenous antioxidants (e.g. Read More

    Antidiabetic effects of SGLT2 inhibitor ipragliflozin in type 2 diabetic mice fed diets containing different carbohydrate contents.
    Life Sci 2018 Feb 6. Epub 2018 Feb 6.
    Candidate Discovery Science Laboratories, Astellas Pharma Inc., Ibaraki, Japan.
    Aims: Daily intake of carbohydrates differs among individual patients with type 2 diabetes. Here, we investigated whether or not dietary carbohydrate content affects the efficacy of the sodium-glucose cotransporter 2 (SGLT2) inhibitor ipragliflozin in type 2 diabetic mice.

    Main Methods: Diabetic mice were fed a regular (50% kcal), high (75% kcal)-, or low (25% kcal)-carbohydrate diet. Read More

    Mesenchymal stem cells pretreated with melatonin ameliorate kidney functions in a rat model of diabetic nephropathy.
    Biochem Cell Biol 2018 Feb 9. Epub 2018 Feb 9.
    Cairo University Kasr Alainy Faculty of Medicine, 63527, Pathology, Cairo, Egypt ;
    The aim of this study was to investigate the effect of Melatonin (MT) pretreated mesenchymal stem cells (MSCs) regenerative therapy, as a new therapeutic target in modifying underlying diabetic nephropathy (DN) pathogenesis in a rat model, and its possible effect on autophagy protein Beclin-1. Forty adult male Wistar albino rats divided into four groups: control, DN, MSCs treated (MSCs) and In-vitro Melatonin (5µM for 24 hours) pre-incubated MSCs treated group (MSCs+MT). MSCs treatment significantly improved the renal functions with amelioration of the measured underlying DN pathogenesis and elevation of Beclin-1 protein levels compared to DN group. Read More

    The KCa3.1 blocker TRAM34 reverses renal damage in a mouse model of established diabetic nephropathy.
    PLoS One 2018 9;13(2):e0192800. Epub 2018 Feb 9.
    Kolling Institute, Sydney Medical School-Northern, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
    Despite optimal control of hyperglycaemia, hypertension, and dyslipidaemia, the number of patients with diabetic nephropathy (DN) continues to grow. Strategies to target various signaling pathways to prevent DN have been intensively investigated in animal models and many have been proved to be promising. However, targeting these pathways once kidney disease is established, remain unsatisfactory. Read More

    Correlations between blood uric acid and the incidence and progression of type 2 diabetes nephropathy.
    Eur Rev Med Pharmacol Sci 2018 Jan;22(2):506-511
    Department of Endocrinology, The First People's Hospital of Wujiang District Suzhou, Suzhou, China.
    Objective: To investigate the relationships between blood uric acid (BUA) level and the incidence, progression and deterioration of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM).

    Patients And Methods: A total of fifty patients with T2DM alone whose glycosylated hemoglobin (HbA1c) were under normal range (4-6.5%) at their admission to our hospital were randomly selected as diabetes mellitus (DM) group. Read More

    Regression of albuminuria and its association with incident cardiovascular outcomes and mortality in type 1 diabetes: the FinnDiane Study.
    Diabetologia 2018 Feb 8. Epub 2018 Feb 8.
    Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, Haartmaninkatu 8, FIN - 00290, Helsinki, Finland.
    Aims/hypothesis: Our aim was to assess regression of albuminuria and its clinical consequences in type 1 diabetes.

    Methods: The analysis included 3642 participants from the Finnish Diabetic Nephropathy (FinnDiane) Study with a 24 h urine sample and a history of albuminuria available at baseline. A total of 2729 individuals had normal AER, 438 a history of microalbuminuria and 475 a history of macroalbuminuria. Read More

    Idiopathic membranous nephropathy in patients with diabetes mellitus: a diagnostic and therapeutic quandary!
    Clin Kidney J 2018 Feb 18;11(1):46-50. Epub 2017 Jul 18.
    Department of Pathology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
    Background: Proteinuria and renal dysfunction is common in diabetic patients and may occur due to variety of causes. Nondiabetic renal diseases (NDRD) account for 30% of the renal biopsies, and idiopathic membranous nephropathy (iMN) is a common non diabetic glomerular disease that can exist alone or in combination with diabetic nephropathy (DN). Immunosuppressants used in iMN may be associated with complications of worsening glycemic control and recurrent infections. Read More

    Management of T1DM in children and adolescents in primary care.
    Malays Fam Physician 2017 31;12(2):18-22. Epub 2017 Aug 31.
    Hospital Kajang, Selangor, Malaysia E-mail:
    The Clinical Practice Guidelines on the Management of Type 1 Diabetes Mellitus in Children & Adolescents was developed by a multidisciplinary development group and approved by the Ministry of Health Malaysia in 2015. A systematic review of 15 clinical questions was conducted using the evidence retrieved mainly from MEDLINE and Cochrane databases. Critical appraisal was done using the Critical Appraisal Skills. Read More

    Silymarin prevents diabetes-induced hyperpermeability in human retinal endothelial cells.
    Endocrinol Diabetes Nutr 2018 Feb 5. Epub 2018 Feb 5.
    Diabetes and Metabolism Research Unit. Vall d'Hebron Research Institute. Universitat Autònoma de Barcelona, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Spain. Electronic address:
    Introduction: Vascular endothelial growth factor (VEGF) plays an essential role in development of diabetic macular edema (DME). While there is evidence suggesting that silymarin, a flavonoid extracted from Silybum marianum, could be useful for prevention and treatment of diabetic nephropathy, no studies have been conducted in diabetic retinopathy (DR). The aim of this study was to assess the effect of silymarin on disruption of inner blood retinal barrier (BRB), the primary cause of DME. Read More

    The Main Determinants of Serum Resistin Level in Type 2 Diabetic Patients are Renal Function and Inflammation not Presence of Microvascular Complication, Obesity and Insulin Resistance.
    Exp Clin Endocrinol Diabetes 2018 Feb 8. Epub 2018 Feb 8.
    Department of Nephrology, Haseki Training and Research Hospital, Istanbul, Turkey.
    Aim: The association of increased resistin levels in chronic kidney disease with diabetic nephropathy has not yet been clarified. Our aim was to analyze the relationship between serum resistin levels and various diabetic microvascular complications in patients.

    Methods: A total of 83 patients were enrolled in this cross-sectional study. Read More

    Swiprosin-1 Promotes Mitochondria-Dependent Apoptosis of Glomerular Podocytes via P38 MAPK Pathway in Early-Stage Diabetic Nephropathy.
    Cell Physiol Biochem 2018 2;45(3):899-916. Epub 2018 Feb 2.
    Department of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, China.
    Background/aims: Podocyte injury, especially podocyte apoptosis, plays a major role in early-stage diabetic nephropathy (DN). Swiprosin-1, also known as EF hand domain containing 2 (EFhd2), is a Ca2+-binding protein in different cell types. However, the function of swiprosin-1 in podocytes remains unknown. Read More

    Association Between Matrix Metalloproteinase-3 Activity and Glomerular Filtration Rate and Albuminuria Status in Patients With Type 2 Diabetes Mellitus.
    Iran J Kidney Dis 2018 Jan;12(1):40-47
    Immunology Research Center; Department of Clinical Biochemistry and Laboratory Medicine; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
    Introduction: Diabetic nephropathy is pictured as matrix accumulation and thickening of glomerular basal membrane. Matrix metalloproteinases (MMPs) are major proteases involved in extracellular matrix degradation. Moreover, plasminogen activator inhibitor-1 (PAI-1) primarily regulates plasmin dependent proteolysis. Read More

    Effects of Coenzyme Q10 Supplementation on Gene Expressions Related to Insulin, Lipid, and Inflammation Pathways in Patients With Diabetic Nephropathy.
    Iran J Kidney Dis 2018 Jan;12(1):14-21
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
    Introduction: Data on the effects of coenzyme Q10 (CQ10) on gene expression related to insulin, lipid, and inflammation in patients with diabetic nephropathy (DN) are scarce. This study aimed to determine the effects of CQ10 supplementation on gene expression related to insulin, lipid, and inflammation pathways in patients with DN.

    Materials And Methods: Forty patients with DN, aged 40 to 85 years old, were randomly assigned into 2 groups to receive either 100 mg/d of CQ10 supplements (n = 20) or placebo (n = 20), for 12 weeks. Read More

    JC polyoma viruria associates with protection from chronic kidney disease independently from apolipoprotein L1 genotype in African Americans.
    Nephrol Dial Transplant 2018 Feb 6. Epub 2018 Feb 6.
    Department of Genetics and Developmental Biology, Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology and Department of Nephrology, Rambam Health Care Campus, Haifa, Israel.
    Background: Viral infections can trigger chronic kidney disease (CKD) and the urine virome may inform risk. The Natural History of APOL1-Associated Nephropathy Study (NHAANS) reported that urine JC polyomavirus (JCPyV) associated with a lower risk of APOL1-associated nephropathy in African Americans. Herein, association was assessed between urine JCPyV with CKD in African Americans independent from the APOL1 genotype. Read More

    Inhibition of SREBP with fatostatin does not attenuate early diabetic nephropathy in male mice.
    Endocrinology 2018 Feb 5. Epub 2018 Feb 5.
    Division of Nephrology, McMaster University at Hamilton, Ontario, Canada L8S4L8.
    Sterol regulatory element binding protein (SREBP) is an important potential mediator of kidney fibrosis, and is known to be upregulated in diabetic nephropathy. Here we evaluate the effectiveness of SREBP inhibition as treatment for diabetic nephropathy.Type 1 diabetes was induced in uninephrectomized male CD1 mice with streptozotocin. Read More

    Galectin-3 is independently associated with progression of nephropathy in type 2 diabetes mellitus.
    Diabetologia 2018 Feb 7. Epub 2018 Feb 7.
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong Special Administrative Region, People's Republic of China.
    Aims/hypothesis: Galectin-3 has been implicated in cardiac and renal fibrosis and serves as a prognostic clinical indicator in heart failure. The aim of the present study was to evaluate whether serum galectin-3 level is associated with progressive kidney disease in type 2 diabetes.

    Methods: Galectin-3 was measured in baseline samples by ELISA in 1320 participants with type 2 diabetes with eGFR ≥30 ml min1. Read More

    1,25-Dihydroxyvitamin Dinhibits the proliferation of rat mesangial cells induced by high glucose via DDIT4.
    Oncotarget 2018 Jan 9;9(1):418-427. Epub 2017 Dec 9.
    Graduate School of Peking Union Medical College, Beijing 100730, China.
    1,25-Dihydroxyvitamin D(1,25(OH)D) is a secosteroid with antiproliferative property. It also plays a pivotal renoprotective role in diabetic nephropathy. We investigated whether 1,25(OH)Dcould inhibit the proliferation of rat mesangial cells exposed to high glucose via the DNA-damage-inducible transcript 4/mammalian target of rapamycin(DDIT4/mTOR) pathway. Read More

    High fructose diet feeding accelerates diabetic nephropathy in Spontaneously Diabetic Torii (SDT) rats.
    J Toxicol Sci 2018 ;43(1):45-58
    Toxicology Research Laboratories, Central Pharmaceutical Research Institute, JAPAN TOBACCO INC.
    Diabetic nephropathy (DN) is one of the complications of diabetes and is now the most common cause of end-stage renal disease. Fructose is a simple carbohydrate that is present in fruits and honey and is used as a sweetener because of its sweet taste. Fructose has been reported to have the potential to progress diabetes and DN in humans even though fructose itself does not increase postprandial plasma glucose levels. Read More

    Proteome Profiling of Diabetic Mellitus Patient Urine for Discovery of Biomarkers by Comprehensive MS-Based Proteomics.
    Proteomes 2018 Feb 6;6(1). Epub 2018 Feb 6.
    Biofluid Biomarker Center, Niigata University, Niigata 950-2181, Japan.
    Diabetic mellitus (DM) is a disease that affects glucose homeostasis and causes complications, such as diabetic nephropathy (DN). For early diagnosis of DN, microalbuminuria is currently one of the most frequently used biomarkers. However, more early diagnostic biomarkers are desired in addition to microalbuminuria. Read More

    Quantitative GC-MS assay of citric acid from humans and db/db mice blood serum to assist the diagnosis of diabetic nephropathy.
    J Chromatogr B Analyt Technol Biomed Life Sci 2018 Mar 31;1077-1078:28-34. Epub 2018 Jan 31.
    Laboratory of Metabolomics, Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China.
    The early diagnosis of diabetic nephropathy (DN) is rather challenging. Our previous study suggested that citric acid is a potential marker for the early diagnosis of diabetic nephropathy in db/db mice. For the first time, in this study, a surrogate analyte ofC-citric acid was employed to generate calibration curves for the quantitative measurement of the endogenous citric acid in the sera of db/db mice and diabetic nephropathy patients by GC/MS after the analytes were extracted, methoximated and trimethylsilylated. Read More

    The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes.
    J Trace Elem Med Biol 2018 Mar 22;46:117-127. Epub 2017 Dec 22.
    Pediatric Research Institute, The Departments of Pediatrics, Radiation Oncology, Pharmacology and Toxicology, The University of Louisville, Louisville, KY 40202, USA.
    Zinc is one of the essential trace elements and participates in numerous physiological processes. Abnormalities in zinc homeostasis often result in the pathogenesis of various chronic metabolic disorders, such as diabetes and its complications. Zinc has insulin-mimetic and anti-diabetic effects and deficiency has been shown to aggravate diabetes-induced oxidative stress and tissue injury in diabetic rodent models and human subjects with diabetes. Read More

    Sodium-glucose cotransporter 2 inhibitors: nephroprotective impact on diabetic kidney disease.
    Cardiovasc Hematol Disord Drug Targets 2018 Feb 6. Epub 2018 Feb 6.
    Veterans Affairs Medical Center, George Washington University. United States.
    Background: Diabetic nephropathy is a crucial microvascular complication of diabetes mellitus that is associated with elevated cardiovascular risk. SGLT-2 inhibitors are a new class of hypoglycemic drugs that positively affect several risk factors of cardiorenal damage.

    Objectives: To review and critically discuss available data on the association of SGLT-2 inhibitors treatment with kidney function, progress of diabetic kidney disease, and renal related outcomes, as well to unveil potential mechanisms of action that mediate such effects. Read More

    Genes associated with Type 2 Diabetes and vascular complications.
    Aging (Albany NY) 2018 Feb 4. Epub 2018 Feb 4.
    Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy.
    Type 2 Diabetes (T2D) is a chronic disease associated with a number of micro- and macrovascular complications that increase the morbidity and mortality of patients. The risk of diabetic complications has a strong genetic component. To this end, we sought to evaluate the association of 40 single nucleotide polymorphisms (SNPs) in 21 candidate genes with T2D and its vascular complications in 503 T2D patients and 580 healthy controls. Read More

    Crocin mediated amelioration of oxidative burden and inflammatory cascade suppresses diabetic nephropathy progression in diabetic rats.
    Chem Biol Interact 2018 Feb 2. Epub 2018 Feb 2.
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
    Diabetic Nephropathy (DN) is one of the main complications associated with diabetes mellitus. Persistently elevated blood glucose level drives histopathological changes in renal tissues that hinder normal kidney functions. In the current study, crocin; the main bioactive constituent of Crocus sativus was investigated as a reno-protective agent against DN by virtue of its numerous pharmacological activities. Read More

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