32,814 results match your criteria Diabetic Nephropathy


Ramipril can alleviate the accumulation of renal mesangial matrix in rats with diabetic nephropathy by inhibiting insulin-like growth factor-11.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000007. Epub 2019 Feb 14.

Master, Department of Nephrology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China. Acquisition of data.

Purpose: To investigate the impact of Ramipril (RAM) on the expressions of insulin-like growth factor-1 (IGF-1) and renal mesangial matrix (RMM) in rats with diabetic nephropathy (DN).

Methods: The Sprague Dawley rats were divided into normal control (NC) group (n = 12), DN group (n = 11), and DN+RAM group (n = 12). The ratio of renal weight to body weight (RBT), fasting blood glucose (FBG), HbA1c, 24-h urine protein (TPU), blood urea nitrogen (BUN), creatinine (Cr), renal pathological changes, the levels of IGF-1, fibronectin (FN), type IV collagen (Col-IV), and matrix metalloproteinases (MMP)-2 were compared among the groups. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000007DOI Listing
February 2019

An experimental study of exenatide effects on renal injury in diabetic rats1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000001. Epub 2019 Feb 14.

Master, Second Department of Endocrinology, Tai'an Central Hospital, China. Design of the study, critical revision, final approval.

Purpose: To investigate the effects of exenatide on renal injury in streptozotocin-induced diabetic rats.

Methods: Fifty SD rats were randomly divided into normal control, model, exenatide-1, exenatide-2 and exenatide-3 groups, 10 rats in each group. The diabetic nephropathy model was constructed in later 4 groups. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000001DOI Listing
February 2019

Huangkui capsule alleviates renal tubular epithelial-mesenchymal transition in diabetic nephropathy via inhibiting NLRP3 inflammasome activation and TLR4/NF-κB signaling.

Phytomedicine 2018 Dec 17;57:203-214. Epub 2018 Dec 17.

Institute of Huangkui, Suzhong Pharmaceutical Group Co., Ltd., 1 Suzhong Road, Taizhou, Jiangsu 225500, China. Electronic address:

Background: Huangkui capsule (HKC), an anti-inflammatory Chinese modern patent medicine, has been now widely applied to the clinical therapy of diabetic nephropathy (DN). However, the overall therapeutic mechanisms in vivo are still unclear. Renal tubular epithelial-to-mesenchymal transition (EMT) is one of the major pathogenesis of renal interstitial fibrosis in DN. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.12.021DOI Listing
December 2018

Allium tuberosum alleviates diabetic nephropathy by supressing hyperglycemia-induced oxidative stress and inflammation in high fat diet/streptozotocin treated rats.

Biomed Pharmacother 2019 Feb 19;112:108678. Epub 2019 Feb 19.

Department of Nephrology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China. Electronic address:

The objective of this study was to evaluate the effect of the butanol fraction from Allium tuberosum (BFAT) in high fat diet/streptozotocin (HFD/STZ) induced diabetic nephropathy. Wistar rats were fed with HFD for 4 weeks and thereafter administered with 35 mg/kg STZ intraperitoneally. Diabetic rats were treated with BFAT (100 or 400 mg/kg) and metformin (150 mg/kg) for 40 days. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108678DOI Listing
February 2019

Klotho attenuates diabetic nephropathy in db/db mice and ameliorates high glucose-induced injury of human renal glomerular endothelial cells.

Cell Cycle 2019 Feb 20. Epub 2019 Feb 20.

a Department of Nephrology , the Second Affiliated Hospital of Nanchang University , Nanchang , China.

Glomerular endothelial cell injury plays an important role in the development and progression of diabetic nephropathy (DN). The expression and function of klotho in glomerular endothelial cells remain unclear. Thus, this study aimed to investigate the expression and the functional role of klotho in DN progression in mice and in high glucose (HG)-induced cell injury of human renal glomerular endothelial cells (HRGECs) and the underlying mechanism. Read More

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http://dx.doi.org/10.1080/15384101.2019.1580495DOI Listing
February 2019

Chemerin/ChemR23 axis promotes inflammation of glomerular endothelial cells in diabetic nephropathy.

J Cell Mol Med 2019 Feb 19. Epub 2019 Feb 19.

Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Diabetic nephropathy (DN) is characterized by inflammation of renal tissue. Glomerular endothelial cells (GEnCs) play an important role in inflammation and protein leakage in urine in DN patients. Chemerin and its receptor ChemR23 are inducers of inflammation. Read More

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http://dx.doi.org/10.1111/jcmm.14237DOI Listing
February 2019

Moringa Isothiocyanate Activates Nrf2: Potential Role in Diabetic Nephropathy.

AAPS J 2019 Feb 19;21(2):31. Epub 2019 Feb 19.

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 228, 160 Frelinghuysen Road, Piscataway, New Jersey, 08854, USA.

Moringa isothiocyanate (MIC-1) is the main active isothiocyanate found in Moringa oleifera, a plant consumed as diet and traditional herbal medicine. Compared to sulforaphane (SFN), MICs are less studied and most work have focused on its anti-inflammatory activity. The purpose of this study is to better understand the Nrf2-ARE antioxidant activity of MIC-1 and its potential in diabetic nephropathy. Read More

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http://dx.doi.org/10.1208/s12248-019-0301-6DOI Listing
February 2019

Interleukin 17A promotes diabetic kidney injury.

Sci Rep 2019 Feb 19;9(1):2264. Epub 2019 Feb 19.

Kidney Node Laboratory, The Charles Perkins Centre, Sydney Medical School, University of Sydney, Sydney, Australia.

The role of the pro-inflammatory cytokine IL-17 in the pathogenesis of numerous inflammatory disorders is well-documented, but conflicting results are reported for its role in diabetic nephropathy. Here we examined the role of IL-17 signalling in a model of streptozotocin-induced diabetic nephropathy through IL-17 knockout mice, administration of neutralising monoclonal anti-IL-17 antibody and in vitro examination of gene expression of renal tubular cells and podocytes under high glucose conditions with or without recombinant IL-17. IL-17 deficient mice were protected against progression of diabetic nephropathy, exhibiting reduced albuminuria, glomerular damage, macrophage accumulation and renal fibrosis at 12 weeks and 24 weeks. Read More

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http://dx.doi.org/10.1038/s41598-019-38811-4DOI Listing
February 2019

MicroRNA-770-5p is involved in the development of diabetic nephropathy through regulating podocyte apoptosis by targeting TP53 regulated inhibitor of apoptosis 1.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1248-1256

Department of Nephrology, The Third Clinical College of Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou, Zhejiang Province, China.

Objective: Diabetic nephropathy (DN) is a major diabetic micro-vascular complication, and podocyte apoptosis induced by high glucose (HG) is a typical early feature of DN. Studies have shown that microRNAs (miRNAs) play a crucial role in the pathogenesis of DN. The purpose of the current study was to explore the role and molecular mechanism of miR-770-5p in podocyte apoptosis in DN. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17018DOI Listing
February 2019

Hydrogen sulfide modulates SIRT1 and suppresses oxidative stress in diabetic nephropathy.

Mol Cell Biochem 2019 Feb 18. Epub 2019 Feb 18.

Pathology Department, Kasr Al Ainy School of Medicine, Cairo University, Kasr Al Ainy St., El Manial, 11562, Cairo, Egypt.

DN is recognized as not only a leading cause of end stage renal disease (ESRD) but also an independent risk factor for cardiovascular disease (CVD). Novel therapeutic approaches to diabetic nephropathy (DN) are needed, or else, healthcare resources will be overwhelmed by the expected worldwide increase in associated cases of ESRD and CVD. Reactive oxygen species (ROS) and advanced glycation end product (AGE) are implicated in the development of DN. Read More

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http://dx.doi.org/10.1007/s11010-019-03506-xDOI Listing
February 2019

Successful Management of Late-Onset Cytomegalovirus-Induced Hemophagocytic Lymphohistiocytosis in Kidney Transplant Recipient After Coronary Artery Bypass Graft Surgery.

Exp Clin Transplant 2019 Jan;17(Suppl 1):207-211

From the Nephrology Department, Hamd Al-Essa Organ Transplant Center of Kuwait, Kuwait.

Hemophagocytic syndrome combines febrile hepatosplenomegaly, pancytopenia, hypofibrinemia, and hepatic dysfunction. It is characterized by bone marrow and organ infiltration of activated, nonmalignant macrophages that phagocytize blood cells. It is rare among renal transplant recipients. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P67DOI Listing
January 2019

Management of Chronic Active Antibody-Mediated Rejection in Renal Transplant Recipients: Single-Center Experience.

Exp Clin Transplant 2019 Jan;17(Suppl 1):113-119

From the Kuwait Ministry of Health, Hamed Al-Essa Organ Transplant Center, Sabah area, Kuwait.

Objectives: Data on the management of chronic antibody-mediated rejection after kidney transplantation are limited. We aimed to assess the impact of treatment of biopsy-proven chronic active antibodymediated rejection with combined plasma exchange, intravenous immunoglobulin, and rituximab treatment versus intravenous immunoglobulin alone or conservative management on the evolution of renal function in renal transplant recipients.

Materials And Methods: In this retrospective study, we compared patients diagnosed with chronic active antibody-mediated rejection who were treated with standard of care steroids, intravenous immunoglobulin, plasma exchange, and rituximab (n = 40) at our center versus those who received intravenous immunoglobulin only or just intensified maintenance immunosuppression (n = 28). Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.O58DOI Listing
January 2019

Predictors of foot care behaviours in patients with diabetes in Turkey.

PeerJ 2019 8;7:e6416. Epub 2019 Feb 8.

Izzet Baysal Education and Research Hospital, Bolu, Turkey.

Background: The management of diabetic foot complications is challenging, time-consuming and costly. Such complications frequently recur, and the feet of individuals with diabetes can be easily infected. The variables that predict foot care behaviours must be identified to improve foot care attitudes and behaviours. Read More

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http://dx.doi.org/10.7717/peerj.6416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369832PMC
February 2019

Lysophosphatidic acid increases mesangial cell proliferation in models of diabetic nephropathy via Rac1/MAPK/KLF5 signaling.

Exp Mol Med 2019 Feb 15;51(2):18. Epub 2019 Feb 15.

Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea.

Mesangial cell proliferation has been identified as a major factor contributing to glomerulosclerosis, which is a typical symptom of diabetic nephropathy (DN). Lysophosphatidic acid (LPA) levels are increased in the glomerulus of the kidney in diabetic mice. LPA is a critical regulator that induces mesangial cell proliferation; however, its effect and molecular mechanisms remain unknown. Read More

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http://dx.doi.org/10.1038/s12276-019-0217-3DOI Listing
February 2019
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IL33/ST2 Axis in Diabetic Kidney Disease: A Literature Review.

Medicina (Kaunas) 2019 Feb 14;55(2). Epub 2019 Feb 14.

School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.

Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is a receptor for IL-33, expressed selectively on a subset of Th2 cells, mediating some of their functions. Read More

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http://dx.doi.org/10.3390/medicina55020050DOI Listing
February 2019
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Metabolomics Approaches for the Diagnosis and Understanding of Kidney Diseases.

Metabolites 2019 Feb 14;9(2). Epub 2019 Feb 14.

Separation Science and Metabolomics Laboratory, Murdoch University, 90 South Street, Perth 6150, Australia.

Diseases of the kidney are difficult to diagnose and treat. This review summarises the definition, cause, epidemiology and treatment of some of these diseases including chronic kidney disease, diabetic nephropathy, acute kidney injury, kidney cancer, kidney transplantation and polycystic kidney diseases. Numerous studies have adopted a metabolomics approach to uncover new small molecule biomarkers of kidney diseases to improve specificity and sensitivity of diagnosis and to uncover biochemical mechanisms that may elucidate the cause and progression of these diseases. Read More

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http://dx.doi.org/10.3390/metabo9020034DOI Listing
February 2019

Calcium Dobesilate and Micro-vascular diseases.

Life Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China; Department of Internal Medicine and Diagnostics, Xuzhou Medical University, Xuzhou 221002, China. Electronic address:

Micro-vascular diseases and its associated complications continue to be a significant health problem worldwide. Vascular lesions from microvascular involvement lead to impaired blood flow and contribute to damage and dysfunction of one or more target organs, that is, the heart, kidneys, eyes, and nervous system. Calcium Dobesilate Drug (CAD) is an established vasoactive and angioprotective drug that has shown a unique, multitarget mode of action in several experimental studies and in different animal models of diabetic microvascular complications. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.023DOI Listing
February 2019

Concurrent neprilysin inhibition and renin-angiotensin system modulations prevented diabetic nephropathy.

Life Sci 2019 Feb 12. Epub 2019 Feb 12.

Laboratory of Molecular Pharmacology, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan 333031, India. Electronic address:

Aims: Renin-angiotensin system (RAS) and natriuretic peptides system (NPS) perturbations govern the development of diabetic nephropathy (DN). Hence, in search of a novel therapy against DN, present study targeted both, NPS and RAS simultaneously using a neprilysin inhibitor (NEPi) in combination with either angiotensin receptor blocker (ARB) or angiotensin-converting enzyme 2 (ACE2) activator.

Methods: We induced diabetes in male Wistar rats by a single dose of streptozotocin (55 mg/kg, i. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.02.027DOI Listing
February 2019
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Effects of gender, age and treatment duration on lipid profile and renal function indices in diabetic patients attending a teaching hospital in South-Western Nigeria.

Afr Health Sci 2018 Dec;18(4):900-908

Department of Biochemistry, School of Sciences, The Federal University of Technology, P.M.B. 704, Akure, Nigeria.

Background: Type 2 Diabetes Mellitus (T2DM) is associated with diabetic nephropathy and hyperlipidemia. Gender, age, medication adherence, lifestyle, culture and socioeconomic status could be sources of diversity in T2DM leading to differences in predisposition, development and clinical presentation.

Objectives: Therefore, this study aimed to investigate the influence of gender, age and treatment duration on kidney and lipid-related biochemical indices of T2DM patients attending Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria (EKSUTH). Read More

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http://dx.doi.org/10.4314/ahs.v18i4.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354870PMC
December 2018
1 Read

Neurons and Microglia; A Sickly-Sweet Duo in Diabetic Pain Neuropathy.

Front Neurosci 2019 31;13:25. Epub 2019 Jan 31.

Département de Pharmacologie et Physiologie, Faculté de Médecine, Université de Montréal, Montréal, QC, Canada.

Diabetes is a common condition characterized by persistent hyperglycemia. High blood sugar primarily affects cells that have a limited capacity to regulate their glucose intake. These cells include capillary endothelial cells in the retina, mesangial cells in the renal glomerulus, Schwann cells, and neurons of the peripheral and central nervous systems. Read More

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http://dx.doi.org/10.3389/fnins.2019.00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365454PMC
January 2019
1 Read

MG132 protects against renal dysfunction by regulating Akt-mediated inflammation in diabetic nephropathy.

Sci Rep 2019 Feb 14;9(1):2049. Epub 2019 Feb 14.

Department of Nephrology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China.

Diabetic nephropathy (DN), the leading cause of end-stage renal disease (ESRD). To date, mounting evidence has shown that inflammation may contribute to the pathogenesis of DN. Recent reports have shown that proteasome inhibitors display cytoprotection by reducing the phosphorylation of Akt, a serine/threonine kinase, plays a critical role in cellular survival and metabolism and can crosstalk with inflammation. Read More

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http://dx.doi.org/10.1038/s41598-018-38425-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375942PMC
February 2019
1 Read
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Occurrence of Diabetic Nephropathy After Renal Transplantation Despite Intensive Glycemic Control: An Observational Cohort Study.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Nephrology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium

Objective: The kinetics and risk factors of diabetic nephropathy after kidney transplantation remain unclear. This study investigated the posttransplant occurrence of diabetic nephropathy and the contribution of posttransplant glycemic control.

Research Design And Methods: We performed a single-center prospective cohort study of 953 renal allograft recipients and 3,458 protocol-specified renal allograft biopsy specimens up to 5 years after transplantation. Read More

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http://dx.doi.org/10.2337/dc18-1936DOI Listing
February 2019
1 Read

Corrigendum to "Schisandrin B alleviates diabetic nephropathy through suppressing excessive inflammation and oxidative stress" Biochem. Biophys. Res. Commun. 508 (2019): 243-249.

Biochem Biophys Res Commun 2019 Feb 12. Epub 2019 Feb 12.

Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.

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http://dx.doi.org/10.1016/j.bbrc.2019.02.027DOI Listing
February 2019
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Erianin protects against high glucose-induced oxidative injury in renal tubular epithelial cells.

Food Chem Toxicol 2019 Feb 11. Epub 2019 Feb 11.

Department of Pharmacy and Master Program, Collage of Pharmacy and Health Care, Tajen University, Pingtung County, 90741, Taiwan. Electronic address:

Erianin is the major bibenzyl compound found in Dendrobium chrysotoxum Lindl. The current study was designed to investigate the protective effects of erianin on high glucose-induced injury in cultured renal tubular epithelial cells (NRK-52E cells) and determine the possible mechanisms for its effects. NRK-52E cells were pretreated with erianin (5, 10, 25 or 50 nmol/L) for 1 h followed by further exposure to high glucose (30 mmol/L, HG) for 48 h. Read More

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http://dx.doi.org/10.1016/j.fct.2019.02.021DOI Listing
February 2019
1 Read

Lysophosphatidic acid receptor 1 inhibitor, AM095, attenuates diabetic nephropathy in mice by downregulation of TLR4/NF-κB signaling and NADPH oxidase.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 11. Epub 2019 Feb 11.

College of Pharmacy, Gachon University, Incheon, Republic of Korea; Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Republic of Korea; Gachon University Gil Medical Center, Gachon Medical and Convergence Institute, Incheon, Republic of Korea. Electronic address:

Diabetic nephropathy (DN) is one of the major long-term complications of diabetes. Lysophosphatidic acid (LPA) signaling has been implicated in renal fibrosis. In our previous study, we found that the LPA receptor 1/3 (LPAR1/3) antagonist, ki16425, protected against DN in diabetic db/db mice. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.001DOI Listing
February 2019
1 Read

[Modern approaches to dietary support for patients with diabetic nephropathy].

Vopr Pitan 2018 13;87(6):6-15. Epub 2018 Nov 13.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow.

The article presents modern approaches to dietary support of patients with diabetic nephropathy (DN) characterized by gradual sclerosis of the renal tissue, leading to a loss of filtration and nitrogen excretory function of the kidneys. An analysis of publications of domestic and foreign authors indicates a slowdown in the progression of chronic kidney disease against the background of low-protein diets. However, the role of protein restriction and its qualitative composition in the diet of patients with DN is the subject of comprehensive discussion. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10061DOI Listing
November 2018

Long noncoding RNA MALAT1 mediates high glucose-induced glomerular endothelial cell injury by epigenetically inhibiting klotho via methyltransferase G9a.

IUBMB Life 2019 Feb 14. Epub 2019 Feb 14.

Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Several recent reporters have indicated the potential role of long noncoding RNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in diabetic nephropathy (DN). However, these studies mainly focus on renal tubular epithelial cells HK-2, the role of MALAT1 in human renal glomerular endothelial cells (HRGECs) remains unclear. Hence, this study aimed to explore the role of MALAT1 in high glucose (HG)-induced HRGECs injury and the underlying epigenetic mechanism. Read More

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http://dx.doi.org/10.1002/iub.2009DOI Listing
February 2019
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Multiple-microarray analysis for identification of hub genes involved in tubulointerstial injury in diabetic nephropathy.

J Cell Physiol 2019 Feb 13. Epub 2019 Feb 13.

Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Diabetic nephropathy (DN) is a primary cause of renal failure. However, studies providing renal gene expression profiles of diabetic tubulointerstitial injury are scarce and its molecular mechanisms still await clarification. To identify vital genes involved in the diabetic tubulointerstitial injury, three microarray data sets from gene expression omnibus (GEO) were downloaded. Read More

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http://dx.doi.org/10.1002/jcp.28313DOI Listing
February 2019
1 Read

Attenuated Lymphatic Proliferation Ameliorates Diabetic Nephropathy and High-Fat Diet-Induced Renal Lipotoxicity.

Sci Rep 2019 Feb 13;9(1):1994. Epub 2019 Feb 13.

Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Lymphangiogenesis occurs in response to renal injury and is correlated with interstitial fibrosis. Diabetes- and high-fat diet (HFD)-induced intrarenal lipotoxicity and their relationships with lymphangiogenesis are not established. We used PPARα agonist, fenofibrate, to unravel the linkage between lipotoxicity and lymphangiogenesis. Read More

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http://dx.doi.org/10.1038/s41598-018-38250-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374395PMC
February 2019
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Efficacy and Safety of Imarikiren in Patients with Type 2 Diabetes and Microalbuminuria: A Randomized, Controlled Trial.

Clin J Am Soc Nephrol 2019 Feb 12. Epub 2019 Feb 12.

Takeda Development Center Japan, Takeda Pharmaceutical Company Limited, Osaka, Japan

Background And Objectives: Imarikiren is a novel, potent, and selective direct renin inhibitor that has shown high oral availability during clinical development for the treatment of diabetic nephropathy. We evaluated the efficacy and safety of imarikiren in patients with type 2 diabetes mellitus and microalbuminuria.

Design, Setting, Participants, & Measurements: This was a randomized, multicenter, placebo-controlled, double-blind, phase 2, dose-finding trial. Read More

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http://dx.doi.org/10.2215/CJN.07720618DOI Listing
February 2019
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Antiphospholipase 2 receptor antibody levels to predict complete spontaneous remission in primary membranous nephropathy.

Clin Kidney J 2019 Feb 9;12(1):36-41. Epub 2018 Mar 9.

Servicio de Nefrología y Trasplante Renal, Hospital Clínic, Departamento de Medicina, Universidad de Barcelona, Institut d' Invesigacions biomèdiques Agust Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Background: M-type phospholipase A2 receptor (APLA2R) is considered the major antigen involved in the pathogenesis of adult primary membranous nephropathy (MN), which is the leading cause of non-diabetic nephrotic syndrome. Antibodies to this antigen have been proved to be an excellent biomarker of disease activity in primary MN. In fact, preliminary data suggest that the higher the antibody level the more proteinuria, and that a decrease in antibody level precedes the remission of proteinuria, but more solid evidence is needed. Read More

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http://dx.doi.org/10.1093/ckj/sfy005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366127PMC
February 2019
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Diabetic Nephropathy in Type 2 Diabetic Retinopathy Requiring Panretinal Photocoagulation.

Korean J Ophthalmol 2019 Feb;33(1):46-53

Department of Ophthalmology and Visual Science, The Catholic University of Korea College of Medicine, Seoul, Korea.

Purpose: To investigate the risk factors of diabetic nephropathy in patients with diabetic retinopathy requiring panretinal photocoagulation (PRP) and the visual prognosis.

Methods: A retrospective review of electronic medical records was conducted at Seoul St. Mary's Hospital, comprising 103 patients with type 2 diabetes mellitus and diabetic retinopathy who underwent PRP from 1996 to 2005. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3341/kjo.2018.00
Publisher Site
http://dx.doi.org/10.3341/kjo.2018.0034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372382PMC
February 2019
3 Reads

Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.

J Cell Physiol 2019 Feb 11. Epub 2019 Feb 11.

Department of Pathology, Hebei Medical University, Shijiazhuang, China.

Thioredoxin-interacting protein (TXNIP) is induced by high glucose (HG), whereupon it acts to inhibit thioredoxin, thereby promoting oxidative stress. We have found that TXNIP knockdown in human renal tubular cells helped prevent the epithelial-to-mesenchymal transition (EMT). Here, we studied the potential effect of TXNIP on podocyte phenotypic alterations in diabetic nephropathy (DN) in vivo and in vitro. Read More

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http://dx.doi.org/10.1002/jcp.28317DOI Listing
February 2019
1 Read

Anti-inflammatory effects of resolvins in diabetic nephropathy: Mechanistic pathways.

J Cell Physiol 2019 Feb 11. Epub 2019 Feb 11.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

The incidence of diabetes mellitus is growing rapidly. The exact pathophysiology of diabetes is unclear, but there is increasing evidence of the role of the inflammatory response in both developing diabetes as well as its complications. Resolvins are naturally occurring polyunsaturated fatty acids that are found in fish oil and sea food that have been shown to possess anti-inflammatory actions in several tissues including the kidneys. Read More

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http://dx.doi.org/10.1002/jcp.28315DOI Listing
February 2019
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Three patients with injection of intravitreal vascular endothelial growth factor inhibitors and subsequent exacerbation of chronic proteinuria and hypertension.

Clin Kidney J 2019 Feb 27;12(1):92-100. Epub 2018 Jul 27.

Retinal Disorders and Ophthalmic Genetics, Department of Ophthalmology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.

Vascular endothelial growth factor (VEGF) receptor inhibition is a commonly used tool to prevent vascular proliferation in tumors and retinal diseases. The antiangiogenic effects of these drugs have made them potent adjunct therapies when given systemically for malignancies. They are also useful tools to ameliorate diminishing eyesight in retinopathy. Read More

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http://dx.doi.org/10.1093/ckj/sfy060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366143PMC
February 2019
1 Read

Sirt6 Suppresses High Glucose-Induced Mitochondrial Dysfunction and Apoptosis in Podocytes through AMPK Activation.

Int J Biol Sci 2019 24;15(3):701-713. Epub 2019 Jan 24.

Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

Previous studies have shown that mitochondrial dysfunction plays an important role in high- glucose(HG)-induced podocyte injury and thus contributes to the progression of diabetic nephropathy(DN). The histone deacetylase Sirtuin6 (Sirt6) has been revealed to have an essential role in the regulation of mitochondrial function in skeletal muscle and cardiomyocytes. However, its specific role in mitochondrial homeostasis in podocytes is undetermined. Read More

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http://dx.doi.org/10.7150/ijbs.29323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367578PMC
January 2019
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Sprout Extract Protect Renal Mesangial Cell Dysfunction against High Glucose by Modulating AMPK and NADPH Oxidase Signaling.

Nutrients 2019 Feb 8;11(2). Epub 2019 Feb 8.

Jeonju AgroBio-Materials Institute, 54810, Wonjangdong-gil 111-27, Deokjin-gu, Jeonju-si 54810, Jeollabuk-do, Korea.

(L.) Britt. var. Read More

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http://dx.doi.org/10.3390/nu11020356DOI Listing
February 2019
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PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.

J Clin Invest 2019 Feb 11. Epub 2019 Feb 11.

Department of Molecular and Cellular Oncology, and.

Epithelial-mesenchymal transition (EMT) contributes significantly to interstitial matrix deposition in diabetic kidney disease (DKD). However, detection of EMT in kidney tissue is impracticable, and anti-EMT therapies have long been hindered. We reported that phosphatase and tensin homolog (PTEN) promoted transforming growth factor beta 1 (TGF-β), sonic hedgehog (SHH), connective tissue growth factor (CTGF), interleukin 6 (IL-6), and hyperglycemia-induced EMT when PTEN was modified by a MEX3C-catalyzed K27-linked polyubiquitination at lysine 80 (referred to as PTENK27-polyUb). Read More

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http://dx.doi.org/10.1172/JCI121987DOI Listing
February 2019
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[Long-term results of chest wall arteriovenous graft for establishing hemodialysis access].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Feb;33(2):227-231

Department of Vascular and Endovascular Surgery, Peking University First Hospital, Beijing, 100034, P.R.China.

Objective: To explore the role of chest wall arteriovenous graft (CWAVG) for establishing hemodialysis access in patients with end-stage renal disease.

Methods: A retrospective analysis was made on the clinical data of 12 patients with end-stage renal disease who underwent CWAVG for establishing hemodialysis access between January 2014 and June 2015. There were 3 males and 9 females with an average age of 63. Read More

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http://dx.doi.org/10.7507/1002-1892.201802003DOI Listing
February 2019
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Insights for Care: The Healthcare Utilisation and Cost Impact of Managing Type 2 Diabetes-Associated Microvascular Complications.

Diabetes Ther 2019 Feb 8. Epub 2019 Feb 8.

Heart of England NHS Foundation Trust, Birmingham, UK.

Introduction: The increasing prevalence of type 2 diabetes (T2DM) in the UK imposes a significant burden on the National Health Service (NHS). Despite the availability of effective treatments, the loss of glycaemic control over time results in significant comorbidities, including nephropathy, neuropathy and retinopathy. The cost of treating these microvascular complications has not been well documented, and this study aimed to provide an accurate assessment of the healthcare resource utilisation (HCRU) associated with managing T2DM and its complications. Read More

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http://dx.doi.org/10.1007/s13300-018-0548-4DOI Listing
February 2019
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Dietary Fiber Intake (Supplemental or Dietary Pattern Rich in Fiber) and Diabetic Kidney Disease: A Systematic Review of Clinical Trials.

Nutrients 2019 Feb 6;11(2). Epub 2019 Feb 6.

Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul. Rua Ramiro Barcelos 2350, Prédio 12, 4º andar, 90035-003, Porto Alegre-RS, Brazil.

Fiber intake is associated with better glycemic control being an important nonpharmacologicaltreatment for diabetes (DM). We hypothesize that a dietary fiber intake can bringbenefits to diabetic kidney disease (DKD), improving renal outcomes. This systematic review aimedto evaluate the effect of dietary fiber (supplemental or dietary pattern rich in fiber) on DKD. Read More

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http://dx.doi.org/10.3390/nu11020347DOI Listing
February 2019
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Spironolactone alleviates diabetic nephropathy through promoting autophagy in podocytes.

Int Urol Nephrol 2019 Feb 8. Epub 2019 Feb 8.

Department of Nephrology, First Hospital of Jilin University, 71 Xinmin Street, Changchun, 130021, Jilin, People's Republic of China.

Purpose: Podocytes are terminally differentiated cells lining the Bowman's capsule. Podocytes are critical for the proper glomerular filtration barrier function. At the same time, autophagy is crucial for maintaining podocyte homeostasis and insufficient autophagy could cause podocyte loss and proteinuria that is commonly observed in diabetic nephropathy (DN). Read More

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http://dx.doi.org/10.1007/s11255-019-02074-9DOI Listing
February 2019
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Vasa recta hyalinosis reflects severe arteriolopathy in renal allografts.

Clin Exp Nephrol 2019 Feb 8. Epub 2019 Feb 8.

Department of Nephrology, Toho University Faculty of Medicine, Tokyo, 143-8541, Japan.

Aim: We examined the clinicopathologic significance of hyalinosis in the vasa recta in the medulla of allograft kidney biopsies.

Method: We analyzed biopsy specimens from January 2010 to December 2015, obtained from both the cortex and medulla (including the vasa recta) ≥ 1 year after living-donor kidney transplantation. We excluded biopsy specimens from recipients who had undergone transplantation due to diabetic nephropathy or who had diabetes mellitus after transplantation. Read More

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http://dx.doi.org/10.1007/s10157-019-01709-6DOI Listing
February 2019
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Verapamil Attenuated Prediabetic Neuropathy in High-Fat Diet-Fed Mice through Inhibiting TXNIP-Mediated Apoptosis and Inflammation.

Oxid Med Cell Longev 2019 10;2019:1896041. Epub 2019 Jan 10.

Department of Endocrinology, Nanfang Hospital, Southern Medical University, China.

Diabetic neuropathy (DN) is a common and severe complication of diabetes mellitus. There is still a lack of an effective treatment to DN because of its complex pathogenesis. Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of thioredoxin, has been shown to be associated with diabetic retinopathy and nephropathy. Read More

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http://dx.doi.org/10.1155/2019/1896041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348807PMC
January 2019
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Global diabetic kidney disease research from 2000 to 2017: A bibliometric analysis.

Authors:
Lu-Xi Zou Ling Sun

Medicine (Baltimore) 2019 Feb;98(6):e14394

Department of Nephrology, Xuzhou Central Hospital, Medical College of Southeast University, Xuzhou, Jiangsu, China.

Background: This study aimed to analyze the scientific outputs of diabetic kidney disease (DKD) research and explore its hotspots and frontiers from 2000 to 2017, using bibliometric methods.

Methods: Articles in DKD research between 2000 and 2017 were retrieved from the Web of Science Core Collection (WoSCC). We used the VOSviewer 1. Read More

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http://dx.doi.org/10.1097/MD.0000000000014394DOI Listing
February 2019
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Epigenetic Risk Profile of Diabetic Kidney Disease in High-Risk Populations.

Curr Diab Rep 2019 Feb 7;19(3). Epub 2019 Feb 7.

Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, 1500 E. Duarte Rd., Duarte, CA, 91010, USA.

Purpose Of Review: Epigenetic variations have been shown to reveal vulnerability to diabetes and its complications. Although it has become clear that metabolic derangements, especially hyperglycemia, can impose a long-term metabolic memory that predisposes to diabetic complications, the underlying mechanisms remain to be understood. It has been suggested that epigenetics (e. Read More

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http://dx.doi.org/10.1007/s11892-019-1129-2DOI Listing
February 2019
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Value of Estimated Glomerular Filtration Rate and Albuminuria in Predicting Cardiovascular Risk in Patients with Type 2 Diabetes without Cardiovascular Disease.

Biomed Res Int 2018 26;2018:8178043. Epub 2018 Dec 26.

Lecturer in Pharmacology, Department of Pharmacology, Faculty of Medicine, University of Ruhuna, PO Box 70, Galle, Sri Lanka.

Introduction: Onset of nephropathy in patients with type 2 diabetes (T2DM) increases the cardiovascular disease (CVD) risk. Association of the parameters of diabetic nephropathy such as albuminuria and estimated Glomerular filtration rate (eGFR) with predicted CVD risk has not been studied in Sri Lankan patients with T2DM.

Methods: In a cross-sectional study of patients who underwent single visit screening at a diabetes center in Sri Lanka, we obtained demographic and biochemical data. Read More

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http://dx.doi.org/10.1155/2018/8178043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343162PMC
December 2018
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Protective Effects of Siebold Fruit Extract against Palmitate-Induced Lipotoxicity in Mesangial Cells.

Evid Based Complement Alternat Med 2019 8;2019:4509403. Epub 2019 Jan 8.

Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of Korea.

Diabetic nephropathy is one of the most serious complications of diabetes. Lipotoxicity in glomerular mesangial cells is associated with the progression of diabetic nephropathy. Paper mulberry, Siebold (BK), has been used in oriental medicine for human health problems. Read More

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http://dx.doi.org/10.1155/2019/4509403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341277PMC
January 2019
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Oleander Stem and Root Standardized Extracts Mitigate Acute Hyperglycaemia by Limiting Systemic Oxidative Stress Response in Diabetic Mice.

Adv Pharmacol Sci 2019 8;2019:7865359. Epub 2019 Jan 8.

Cellular Immunology Laboratory, Department of Zoology, University of North Bengal, Siliguri, West Bengal 734013, India.

The extracts of different parts of L. are used as antidiabetic remedy in the traditional medicinal systems of different parts of the world. Despite these uses in ethnomedicinal system, the antihyperglycemic potentials of oleander stem (NOSE) and root (NORE) extracts have not been pharmacologically evaluated. Read More

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http://dx.doi.org/10.1155/2019/7865359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341266PMC
January 2019
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