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    Relationships between chronic comorbidities and the atherosclerosis indicators ankle-brachial index and brachial-ankle pulse wave velocity in patients with type 2 diabetes mellitus.
    J Investig Med 2018 Apr 24. Epub 2018 Apr 24.
    Department of Medicine, Mackay Medical Collage, New Taipei City, Taiwan.
    This study aimed to determine associations between ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) with different comorbidities in patients with type 2 diabetes mellitus (DM). Records of patients with type 2 DM who received an ABI and baPWV examination between August 2013 and February 2015 were retrospectively reviewed. Associations of ABI and baPWV with chronic kidney disease (CKD), chronic liver disease (CLD), coronary artery disease (CAD) and diabetic nephropathy (DN) were examined by regression analysis. Read More

    Clinical assessment and treatment of diabetes in patients with chronic kidney disease.
    Rev Clin Esp 2018 Apr 21. Epub 2018 Apr 21.
    Servicio de Medicina Interna, Hospital Comarcal de Zafra, Badajoz, España.
    Diabetes mellitus type 2 is the main cause of chronic kidney disease. Patients with this disease have higher morbidity and mortality and risk of hypoglycaemia than those without this disease. In 2010, type 2 diabetes was the reason for starting renal replacement therapy in 24. Read More

    SIRT3 Facilitates Amniotic Fluid Stem Cells to Repair Diabetic Nephropathy Through Protecting Mitochondrial Homeostasis by Modulation of Mitophagy.
    Cell Physiol Biochem 2018 Apr 19;46(4):1508-1524. Epub 2018 Apr 19.
    Background/aims: Amniotic fluid stem cells (AFSCs) transplantation is a promising therapeutic strategy for diabetic nephropathy. Sirtuin3 (SIRT3) is a novel mitochondrial protective factor. In the present study, we aimed to investigate whether SIRT3 protects against hyperglycemia-induced AFSCs damage and enhances the therapeutic efficiency of AFSCs in diabetic nephropathy. Read More

    Urinary and Blood MicroRNA-126 and -770 are Potential Noninvasive Biomarker Candidates for Diabetic Nephropathy: a Meta-Analysis.
    Cell Physiol Biochem 2018 Apr 18;46(4):1331-1340. Epub 2018 Apr 18.
    Department of Genome Medicine and Science, Gachon University College of Medicine, Incheon, Republic of Korea.
    Background/aims: Diabetic nephropathy (DN), a major diabetic microvascular complication, has a long and growing list of biomarkers, including microRNA biomarkers, which have not been consistent across preclinical and clinical studies. This meta-analysis aims to identify significant blood- and urine-incident microRNAs as diagnostic/prognostic biomarker candidates for DN.

    Methods: PubMed, Web of Science, and Cochrane Library were searched from their earliest records through 12th Dec 2016. Read More

    Fine structural characterization of sulodexide.
    J Pharm Biomed Anal 2018 Apr 15;156:67-79. Epub 2018 Apr 15.
    Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, Milan, Italy. Electronic address:
    Sulodexide is a heparinoid which combines the properties of its components heparin and dermatan sulfate and is used not only for the prophylaxis and treatment of thromboembolic diseases but also for the treatment of diabetic nephropathy. Despite many clinical studies have been conducted to investigate its activity and safety, no data are available on the fine chemical characterization of its components. In this work, the in-depth investigation on the structural features of both the whole mixture and the isolated components was accomplished, involving the analysis of molecular weight distribution and of their mono, di and oligosaccharide composition by HP-SEC/TDA, 2D-NMR and HPLC-MS techniques. Read More

    Osteopontin as a marker of vasculopathy in pediatric patients with type 1 diabetes mellitus: relation to vascular structure.
    Pediatr Diabetes 2018 Apr 23. Epub 2018 Apr 23.
    Pediatrics Department, Faculty of Medicine, Ain Shams University.
    Background: Type 1 diabetes mellitus (T1DM) is associated with serious micro-vascular and macrovascular complications. Osteopontin (OPN) has emerged as a strong predictor of incipient diabetic nephropathy and a first-ever cardiovascular event in adults with T1DM. OPN is linked to coronary atherosclerosis in type 2 diabetes. Read More

    Monitoring of patients with type 2 diabetes and nephropathy in a specialized diabetic nephropathy clinic seems to be beneficial.
    Diabetes Metab Syndr 2018 Apr 13. Epub 2018 Apr 13.
    Department of Endocrinology, Diabetes & Metabolism, Evangelismos Hospital, Athens, Greece.
    Background: The purpose of this study was to evaluate the outcome of DM2 patients with nephropathy when they are under surveillance of a joined clinic run by endocrinologists & nephrologists.

    Patients And Methods: A cohort of 106 patients with DM2, 42-83 years of age, and eGFR < 60 ml/min/m were included. Age, sex, duration of diabetes, duration of attending our clinic, smoking habits, BMI, data regarding ischemic heart disease and induction of hemodialysis, urine albumin excretion (UAE) levels, eGFR (MDRD equation) and values of various biochemical parameters were recorded too. Read More

    Mapping Txnip: Key connexions in progression of diabetic nephropathy.
    Pharmacol Rep 2017 Dec 20;70(3):614-622. Epub 2017 Dec 20.
    Neuropharmacology Division, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh, India.
    Studies demonstrates the major involvement of inflammatory and apoptotic pathway in the pathophysiology of diabetic nephropathy. The cross talk between inflammatory and apoptotic pathway suggests Txnip as a molecular connexion in progression of disease state. Txnip modulates inflammatory pathway (via ROS production and NLRP3 inflammasome activity) and apoptotic pathway (via mTOR pathway). Read More

    Serum fibrinogen predicts diabetic ESRD in patients with type 2 diabetes mellitus.
    Diabetes Res Clin Pract 2018 Apr 20. Epub 2018 Apr 20.
    Division of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China. Electronic address:
    Aims: Although increased serum fibrinogen level was often observed in patients with diabetic nephropathy (DN), its association with DN severity and progression remains unclear. The aim of this study was to investigate the relationship between the serum fibrinogen levels and clinicopathological features and renal prognosis in Chinese patients with type 2 diabetes mellitus (T2DM) and DN.

    Methods: A total of 174 patients with T2DM and biopsy-proven DN were enrolled. Read More

    Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats.
    Phytother Res 2018 Apr 23. Epub 2018 Apr 23.
    College of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology, Suzhou, 215009, China.
    Rhizome of Anemarrhena asphodeloides Bunge (AA, family Liliaceae) has been widely used in China for thousands of years to treat febrile diseases and diabetes. Steroidal saponins from AA show good antidiabetes effects and ameliorate diabetic complications. This study was designed to investigate the effects of sarsasapogenin (Sar), a major sapogenin from AA, on diabetic nephropathy (DN) in rats, and to explore the possible mechanisms. Read More

    Therapeutic Effects of Tangshen Formula on Diabetic Nephropathy in Mice Using Cytokine Antibody Array.
    J Diabetes Res 2018 22;2018:8237590. Epub 2018 Feb 22.
    Beijing Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China.
    Objective: Cytokines are essential promoters in the pathogenesis of diabetic nephropathy (DN) in type 2 diabetes. The following study investigates the adjustment mechanism of formula (TSF) on cytokine expressions in mice (DN animal model).

    Materials And Methods: mice were randomly divided into three groups. Read More

    Glomerular Filtration Rate and/or Ratio of Urine Albumin to Creatinine as Markers for Diabetic Retinopathy: A Ten-Year Follow-Up Study.
    J Diabetes Res 2018 26;2018:5637130. Epub 2018 Feb 26.
    Unitat de Suport a la Recerca Barcelona Ciutat, Institut Universitari d'Investigacio en Atencio Primaria Jordi Gol (IDIAP Jordi Gol), Universitat Autonoma de Barcelona, Bellaterra, Spain.
    Aims: To determine the relationship between diabetic nephropathy and diabetic retinopathy on a population of type 2 diabetes mellitus patients.

    Methods: A prospective ten-year follow-up population-based study. We determined differences between estimated glomerular filtration rate (eGFR) using the chronic kidney disease epidemiology collaboration equation and urine albumin to creatinine ratio. Read More

    Growth Differentiation Factor-15 as a Predictor of Idiopathic Membranous Nephropathy Progression: A Retrospective Study.
    Dis Markers 2018 22;2018:1463940. Epub 2018 Feb 22.
    Division of Nephrology, Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea.
    Idiopathic membranous nephropathy (IMN) is a major cause of nephrotic syndrome. No biomarker to predict the long-term prognosis of IMN is currently available. Growth differentiation factor-15 (GDF-15) is a member of the transforming growth factor- superfamily and has been associated with chronic inflammatory disease. Read More

    Tangshen Formula Attenuates Diabetic Nephropathy by Promoting ABCA1-Mediated Renal Cholesterol Efflux in db/db Mice.
    Front Physiol 2018 6;9:343. Epub 2018 Apr 6.
    Beijing Key Lab Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.
    The commonly prescribed Tangshen Formula (TSF) is a traditional Chinese formulation that has been shown to reduce plasma lipid metabolism and proteinuria and improve the estimated glomerular filtration rate (eGFR) in patients with diabetic kidney disease. This study investigated the underlying mechanism whereby TSF regulates renal lipid accumulation and ameliorates diabetic renal injuries in spontaneous diabetic db/db mice and in sodium palmitate (PA)-stimulated and Abca1-SiRNA-transfected mouse tubular epithelial cells (mTECs). The results revealed that TSF treatment significantly ameliorated the renal injuries by lowering urinary albumin excretion and improving renal tissue injuries in diabetic (db/db) mice. Read More

    Actin dynamics at focal adhesions: a common endpoint and putative therapeutic target for proteinuric kidney diseases.
    Kidney Int 2018 Apr 17. Epub 2018 Apr 17.
    Department of Nephrology, Hannover Medical School, Hannover, Germany. Electronic address:
    Proteinuria encompasses diverse causes including both genetic diseases and acquired forms such as diabetic and hypertensive nephropathy. The basis of proteinuria is a disturbance in size selectivity of the glomerular filtration barrier, which largely depends on the podocyte: a terminally differentiated epithelial cell type covering the outer surface of the glomerulus. Compromised podocyte structure is one of the earliest signs of glomerular injury. Read More

    Risk Prediction of Diabetic Nephropathy via Interpretable Feature Extraction from EHR Using Convolutional Autoencoder.
    Stud Health Technol Inform 2018 ;247:106-110
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Fujita Health University, Japan.
    This paper describes a technology for predicting the aggravation of diabetic nephropathy from electronic health record (EHR). For the prediction, we used features extracted from event sequence of lab tests in EHR with a stacked convolutional autoencoder which can extract both local and global temporal information. The extracted features can be interpreted as similarities to a small number of typical sequences of lab tests, that may help us to understand the disease courses and to provide detailed health guidance. Read More

    [Effect of Shenqi Dihuang decoction on inflammatory factor, renal function and microcirculation in patients with early diabetic nephropathy].
    Zhongguo Zhong Yao Za Zhi 2018 Mar;43(6):1276-1281
    First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
    To study the effect of Shenqi Dihuang decoction on inflammatory factor, renal function and microcirculation in patients with early diabetic nephropathy. A total of 205 cases of patient with early diabetic nephropathy treated in our hospital from March 2014 to April 2016 were selected and divided into two groups according to the admitted order, with 103 cases in clinical group and 102 in control group. Patients in control group were treated with melbine and captopril, which may be adjusted according to the clinical symptom. Read More

    Serum ApoA4 levels predicted the progression of renal impairment in T2DM.
    Eur J Clin Invest 2018 Apr 19:e12937. Epub 2018 Apr 19.
    Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, 11490, Taiwan.
    Background: Among multiple causes, diabetic nephropathy (DN) is the major underlying renal disease that leads to end-stage renal disease (ESRD), and early diagnosis can effectively prevent or delay the progression to ESRD. Therefore, the current study aimed to develop non-invasive, accurate detection markers.

    Materials & Methods: For this study, 62 diabetes mellitus (DM) patients, 59 DN patients, and 21 healthy controls (HCs) were recruited. Read More

    Associations of Diabetic Retinopathy with Retinal Neurodegeneration on the Background of Diabetes Mellitus. Overview of Recent Medical Studies with an Assessment of the Impact on Healthcare systems.
    Open Med (Wars) 2018 18;13:130-136. Epub 2018 Apr 18.
    Ophthalmology Clinic Medical Centre of Postgraduate Education Warsaw, Warsaw Poland.
    Diabetes Mellitus (DM) is one of the biggest healthcare and financial problems worldwide. The disease is strongly associated with microvascular and macrovascular complications, causing co-existing diseases like Diabetic Retinopathy, Diabetic Neuropathy and Diabetic Nephropathy. Annual healthcare expenditures for diabetes treatment and complications prevention cost 727 billion USD in year 2017. Read More

    Sweet Taste Receptors Mediated ROS-NLRP3 Inflammasome Signaling Activation: Implications for Diabetic Nephropathy.
    J Diabetes Res 2018 20;2018:7078214. Epub 2018 Feb 20.
    Department of Endocrinology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
    Previous studies demonstrated that ROS-NLRP3 inflammasome signaling activation was involved in the pathogenesis of diabetic nephropathy (DN). Recent research has shown that sweet taste receptors (STRs) are important sentinels of innate immunity. Whether high glucose primes ROS-NLRP3 inflammasome signaling via STRs is unclear. Read More

    Urinary angiotensinogen excretion in Australian Indigenous and non-Indigenous pregnant women.
    Pregnancy Hypertens 2018 Apr 11;12:110-117. Epub 2018 Apr 11.
    School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan, New South Wales, Australia; Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, New South Wales, Australia; Mothers and Babies Research Centre, Hunter Medical Research Institute, New Lambton, New South Wales, Australia.
    The intrarenal renin-angiotensin system (iRAS) is implicated in the pathogenesis of hypertension, chronic kidney disease and diabetic nephropathy. Urinary angiotensinogen (uAGT) levels reflect the activity of the iRAS and are altered in women with preeclampsia. Since Indigenous Australians suffer high rates and early onset of renal disease, we hypothesised that Indigenous Australian pregnant women, like non-Indigenous women with pregnancy complications, would have altered uAGT levels. Read More

    Utility of urinary biomarkers as a diagnostic tool for early diabetic nephropathy in patients with type 2 diabetes mellitus.
    Diabetes Metab Syndr 2018 Apr 12. Epub 2018 Apr 12.
    Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Puducherry, India. Electronic address:
    Introduction: Renal tubulo-interstitial damage has an important role in the pathogenesis of early diabetic nephropathy. Urinary biomarkers can help in the detection of early nephropathy in type 2 diabetic patients. The aim of this study was to estimate the levels of urinary neutrophil gelatinase associated lipocalin (NGAL) and cystatin-C in type 2 diabetic patients with early diabetic nephropathy & to compare them with diabetic patients without nephropathy and to correlate urinary NGAL and cystatin-C levels with microalbuminuria in them. Read More

    Role of atrial natriuretic peptide in controlling diabetic nephropathy in rats.
    J Basic Clin Physiol Pharmacol 2018 Apr 19. Epub 2018 Apr 19.
    Department of Pharmacology, Maharishi Markandeshwar University, Mullana, Haryana, India.
    Background: Diabetes is a downregulator of atrial natriuretic peptide (ANP), resulting in reduced nitric oxide level and low expression of endothelial nitric oxide synthase by which nitric oxide level get reduced. In the present study, we examined the role of ANP in reduced nitric oxide level, which may be responsible in controlling diabetic nephropathy in rats.

    Methods: Serum nitrite/nitrate ratio, blood urea nitrogen, protein in urine, urinary output, serum creatinine, serum cholesterol, kidney weight, kidney hypertrophy, renal cortical collagen content, thiobarbituric acid level, and antioxidant enzymatic activities were assessed. Read More

    Garlic (Allium sativum) increases SIRT1 and SIRT2 gene expressions in the kidney and liver tissues of STZ- and STZ+niacinamide-induced diabetic rats.
    J Basic Clin Physiol Pharmacol 2018 Apr 19. Epub 2018 Apr 19.
    Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
    Background: Diabetic nephropathy and liver damage are important complications of diabetes mellitus (DM). Various factors, such as sirtuins (silent information regulators or SIRTs) are associated with these complications. Sirtuins are a family of NAD+-dependent proteins, and seven types of these can be found in mammalians. Read More

    Noninvasive Real-Time Characterization of Renal Clearance Kinetics in Diabetic Mice after Receiving Danshensu Treatment.
    Oxid Med Cell Longev 2018 12;2018:8267560. Epub 2018 Feb 12.
    Department of Health Technology and Informatics, Hong Kong Polytechnic University, Kowloon, Hong Kong.
    Danshensu (DSS) is an active ingredient extracted from the root of the Danshen that could ameliorate oxidative stress via upregulation of heme oxygenase- (HO-) 1. Little is known about the treatment effects of DSS on kidney function in diabetic mice. Therefore, the primary aim of the present study was to characterize the renal clearance kinetics of IRdye800CW in mice after DSS treatment. Read More

    Renal protective effect of Paeoniflorin by inhibition of JAK2/STAT3 signaling pathway in diabetic mice.
    Biosci Trends 2018 Apr 19. Epub 2018 Apr 19.
    Department of Nephrology, the First Affiliated Hospital, Anhui Medical University.
    Paeoniflorin is the main bioactive components of the root of P.lactiflora Pall., and has been widely used as an anti-inflammation and immunomodulatory agent. Read More

    The role of dipeptidylpeptidase-4 inhibitors in management of cardiovascular disease in diabetes; focus on linagliptin.
    Cardiovasc Diabetol 2018 Apr 18;17(1):59. Epub 2018 Apr 18.
    Diabetes and Cardiovascular Center, University of Missouri School of Medicine, Columbia, MO, USA.
    Multiple population based analyses have demonstrated a high incidence of cardiovascular disease (CVD) and cardiovascular (CV) mortality in subjects with T2DM that reduces life expectancy by as much as 15 years. Importantly, the CV system is particularly sensitive to the metabolic and immune derangements present in obese pre-diabetic and diabetic individuals; consequently, CV dysfunction is often the initial CV derangement to occur and promotes the progression to end organ/tissue damage in T2DM. Specifically, diabetic CVD can manifest as microvascular complications, such as nephropathy, retinopathy, and neuropathy, as well as, macrovascular impairments, including ischemic heart disease, peripheral vascular disease, and cerebrovascular disease. Read More

    Effect of post-transplant glycemic control on long-term clinical outcomes in kidney transplant recipients with diabetic nephropathy: A multicenter cohort study in Korea.
    PLoS One 2018 18;13(4):e0195566. Epub 2018 Apr 18.
    Department of Medical Science, Seoul National University College of Medicine, Seoul, Korea.
    Purpose: Diabetic nephropathy is the leading cause of end stage renal disease. The number of kidney transplantation (KT) due to diabetic nephropathy is increasing and there is debate on glycemic control after KT. In this study, we used a multi-center database to determine the relationship between post-transplant glycemic control and the outcomes of KT in patients with diabetic nephropathy. Read More

    Tolvaptan alleviates excessive fluid retention of nephrotic diabetic renal failure unresponsive to furosemide.
    Nephrology (Carlton) 2018 Apr 17. Epub 2018 Apr 17.
    Department of Endocrinology, Diabetes and Metabolism, Kitasato University School of Medicine, Kanagawa, Japan.
    Patients with diabetic nephropathy develop nephrotic syndrome, and may show limited response to conventional therapy. They often require earlier initiation of renal replacement therapy because they become refractory to diuretics, and experience excessive fluid retention. We aimed to investigate the efficacy of tolvaptan, an oral arginine vasopressin type 2 receptor antagonist, in a case series of 14 severe diabetic renal failure patients who were severely refractory to maximal doses of furosemide and had excessive fluid retention despite preserved cardiac function and residual renal function. Read More

    Hyporeninemic hypoaldosteronism in a patient with diabetes mellitus: an unforgettable case report.
    Int Med Case Rep J 2018 3;11:69-72. Epub 2018 Apr 3.
    Department of Diabetes & Endocrinology, Peterborough City Hospital, Peterborough, UK.
    A 58-year-old man presented with a 3-year history of chronic and intermittent hyperkalemia requiring recurrent attendances to the emergency department for urgent treatment. His medical history included secondary diabetes mellitus following a bout of acute pancreatitis and a previous splenectomy for a spontaneous splenic rupture. He also had a history of prolonged use of non-steroidal anti-inflammatory drugs for back pain and painful neuropathy. Read More

    Effect of neprilysin inhibition on renal function in patients with type 2 diabetes and chronic heart failure who are receiving target doses of inhibitors of the renin-angiotensin system: a secondary analysis of the PARADIGM-HF trial.
    Lancet Diabetes Endocrinol 2018 Apr 13. Epub 2018 Apr 13.
    Medical University of South Carolina and Ralph H Johnson Veterans Administration Medical Center, Charleston, SC, USA.
    Background: Neprilysin inhibition has favourable effects on experimental diabetic nephropathy. We sought to assess the effects of neprilysin inhibition on the course of renal function in patients with type 2 diabetes.

    Methods: In the randomised, double-blind PARADIGM-HF trial, the effects of sacubitril/valsartan (97 mg/103 mg twice daily) were compared with enalapril (10 mg twice daily) in 8399 patients with mild-to-moderate chronic heart failure and systolic dysfunction. Read More

    Renopancreatic Transplantation: Evaluation of 15 Years in 131 Patients.
    Transplant Proc 2018 Apr;50(3):792-795
    Department of Nefrology, Angelina Caron Hospital, Campina Grande do Sul, Paraná, Brazil.
    Background: The most common multiple-organ transplant is the simultaneous pancreas-kidney transplantation (SPK). It is usually offered to patients who have insulin-dependent diabetes mellitus and those with diabetic nephropathy and renal failure that has already been established. In this study we present the results of 15 years of SPK in a transplant hospital center in Paraná, Brazil, and evaluated survival, immunosuppression, and transplant-related problems. Read More

    Thyroid hormones and diabetic nephropathy: an essential relationship to recognize.
    Nephrology (Carlton) 2018 Apr 16. Epub 2018 Apr 16.
    Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China.
    Aims: Although abnormal thyroid hormone metabolism is common in patients with 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN), the relationship between thyroid hormones and DN is unclear and being ignored during the clinical practice. This study was aimed to investigate the relationship between thyroid hormones and clinicopathologic changes in biopsy-proven DN patients.

    Methods: We collected clinical and pathological data for 146 biopsy-proven DN patients. Read More

    The 6-hydroxychromanol derivative SUL-109 ameliorates renal injury after deep hypothermia and rewarming in rats.
    Nephrol Dial Transplant 2018 Apr 11. Epub 2018 Apr 11.
    Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
    Background: Mitochondrial dysfunction plays an important role in kidney damage in various pathologies, including acute and chronic kidney injury and diabetic nephropathy. In addition to the well-studied ischaemia/reperfusion (I/R) injury, hypothermia/rewarming (H/R) also inflicts acute kidney injury. Substituted 6-hydroxychromanols are a novel class of mitochondrial medicines that ameliorate mitochondrial oxidative stress and protect the mitochondrial network. Read More

    Uric acid is not associated with diabetic nephropathy and other complications in type 1 diabetes.
    Nephrol Dial Transplant 2018 Apr 11. Epub 2018 Apr 11.
    Steno Diabetes Center Copenhagen, Gentofte, Denmark.
    Background: To examine the association between plasma uric acid (UA) and the presence of diabetic complications including diabetic nephropathy and cardiovascular risk factors in patients with type 1 diabetes.

    Methods: This study, which is cross-sectional in design, included 676 Caucasian type 1 diabetes patients from the Steno Diabetes Center Copenhagen. Participants with UA within the three lowest sex-specific quartiles were compared with participants with levels in the highest quartile. Read More

    Spectrum of biopsy-proven renal diseases: A single center experience.
    Saudi J Kidney Dis Transpl 2018 Mar-Apr;29(2):392-400
    Department of Nephrology, DM Waynad Institute of Medical Sciences, Waynad, Kerala, India.
    Kidney biopsy is one of the most important tools in the assessment of kidney disease as histopathological diagnosis promotes evidence-based practice in Nephrology. This study included 271 consecutive percutaneous kidney biopsies (145 males and 126 females) performed at EMS Memorial Cooperative Hospital, Perinthalmanna, Kerala, India, from September 2009 to March 2016. Among the biopsy-proven renal diseases (BPRD), primary glomerular diseases (PGD) were the most common (77. Read More

    Novel reno-protective mechanism of Aspirin involves H2AK119 monoubiquitination and Set7 in preventing type 1 diabetic nephropathy.
    Pharmacol Rep 2017 Dec 2;70(3):497-502. Epub 2017 Dec 2.
    Laboratory of Molecular Pharmacology, Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Rajasthan, India. Electronic address:
    Background: Even after several novel therapeutic approaches, the number of people with diabetic nephropathy (DN) still continues to increase globally, this suggest to find novel therapeutic strategies to prevent it completely. Recent reports, are indicating the ubiquitin proteasome system alterations in DN. Recently, we also showed that, histone H2AK119 mono-ubiquitination (H2AK119-Ub) found to regulate Set7, a key epigenetic enzyme in the development of renal fibrosis under type 1 diabetic condition. Read More

    Activation of GSK3β/β-TrCP axis via PHLPP1 exacerbates Nrf2 degradation leading to impairment in cell survival pathway during diabetic nephropathy.
    Free Radic Biol Med 2018 Apr 12;120:414-424. Epub 2018 Apr 12.
    Herbal Research Laboratory, Food, Drug & Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India; Babu Banarasi Das University, Lucknow, Uttar Pradesh, India; Academy of Scientific and Innovative Research, CSIR-IITR Campus, Lucknow, Uttar Pradesh, India. Electronic address:
    NF-E2 p45-related factor 2 (Nrf2), is a major redox sensitive transcription factor that plays an essential role in regulating glucose metabolism. Inactivation of Nrf2 has been associated with diabetic complications however, mechanisms warranting Nrf2 suppression are incompletely understood. We hypothesized that PHLPP1 activates GSK3β to induce β-TrCP mediated Nrf2 phosphorylation and degradation. Read More

    Proteomics for Biomarker Identification and Clinical Application in Kidney Disease.
    Adv Clin Chem 2018 6;85:91-113. Epub 2018 Mar 6.
    Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Science, Northwest University, Xi'an, China. Electronic address:
    Treatment effectiveness for kidney disease is limited by lack of accuracy, sensitivity, specificity of diagnostic, prognostic, and therapeutic biomarkers. The gold standard test renal biopsy along with serum creatinine and proteinuria is often necessary to establish a diagnosis, particularly in glomerular disease. Proteomics has become a powerful tool for novel biomarker discovery in kidney disease. Read More

    Tolvaptan alleviates excessive fluid retention of nephrotic diabetic renal failure unresponsive to furosemide.
    Nephrology (Carlton) 2018 Apr 14. Epub 2018 Apr 14.
    Department of Endocrinology, Diabetes and Metabolism, Kitasato University School of Medicine, Kanagawa, Japan.
    Patients with diabetic nephropathy develop nephrotic syndrome, and may show limited response to conventional therapy. They often require earlier initiation of renal replacement therapy because they become refractory to diuretics, and experience excessive fluid retention. We aimed to investigate the efficacy of tolvaptan, an oral arginine vasopressin type 2 receptor antagonist, in a case series of 14 severe diabetic renal failure patients who were severely refractory to maximal doses of furosemide and had excessive fluid retention despite preserved cardiac function and residual renal function. Read More

    Knockdown of NLRC5 attenuates renal I/R injury in vitro through the activation of PI3K/Akt signaling pathway.
    Biomed Pharmacother 2018 Apr 11;103:222-227. Epub 2018 Apr 11.
    Department of Kidney Transplantation, Hospital of Nephropathy, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China; Institute of Organ Transplantation, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China. Electronic address:
    NLRC5, as the largest member of nucleotide-binding domain and leucine-rich repeat (NLR) family, was involved in various physiological processes, such as inflammation, fibrosis, innate immunity and diabetic nephropathy. However, the role of NLRC5 in acute kidney injury remains unclear. The aim of this study was to investigate the role of NLRC5 in human renal proximal tubular epithelial cells (HK-2) exposed to hypoxia/reoxygenation (H/R). Read More

    Renal Effects of Incretin-Based Diabetes Therapies: Pre-clinical Predictions and Clinical Trial Outcomes.
    Curr Diab Rep 2018 Apr 13;18(5):28. Epub 2018 Apr 13.
    University of California, 3350 La Jolla Village Drive 9151, San Diego, CA, 92161, USA.
    Purpose Of Review: The purpose of this review is to correlate predictions based on pre-clinical data with outcomes from clinical trials that examine the effects of incretin-based diabetes treatments on the kidney. The incretin-based treatments include agonists of the glucagon-like peptide 1 receptor (GLP-1R) and inhibitors of the enzyme, dipeptidyl peptidase-4 (DPP-4). In addition, what is known about the incretin-based therapies will be compared to what is known about the renal effects of SGLT2 inhibitors. Read More

    Hedgehog Interacting Protein Promotes Fibrosis and Apoptosis in Glomerular Endothelial Cells in Murine Diabetes.
    Sci Rep 2018 Apr 13;8(1):5958. Epub 2018 Apr 13.
    Université de Montréal Department of Medicine Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM) Tour Viger, 900 rue Saint-Denis, Montréal, QC, H2X 0A9, Canada.
    We investigated whether renal hedgehog interacting protein (Hhip) expression contributes to the progression of diabetic nephropathy (DN) and studied its related mechanism(s) in vivo and in vitro. Here, we show that Hhip expression is highly elevated in glomerular endothelial cells of adult type 1 diabetic (T1D) Akita and T2D db/db mouse kidneys as compared to non-diabetic control littermates. Hyperglycemia enhances reactive oxygen species (ROS) generation via NADPH oxidase 4 (Nox4) activation and stimulates renal Hhip gene expression, and that elevated renal Hhip gene expression subsequently activates the TGFβ1- Smad2/3 cascade and promotes endothelial to mesenchymal transition associated with endothelial cell fibrosis/apoptosis in vivo and in vitro. Read More

    CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease.
    Nat Rev Nephrol 2018 Apr 13. Epub 2018 Apr 13.
    Department of Nephrology, Hannover Medical School, Hannover, Germany.
    The increasing global prevalence of type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) has prompted research efforts to tackle the growing epidemic of diabetic kidney disease (DKD; also known as diabetic nephropathy). The limited success of much of this research might in part be due to the fact that not all patients diagnosed with DKD have renal dysfunction as a consequence of their diabetes mellitus. Patients who present with CKD and diabetes mellitus (type 1 or type 2) can have true DKD (wherein CKD is a direct consequence of their diabetes status), nondiabetic kidney disease (NDKD) coincident with diabetes mellitus, or a combination of both DKD and NDKD. Read More

    Intrarenal delivery of bFGF-loaded liposome under guiding of ultrasound-targeted microbubble destruction prevent diabetic nephropathy through inhibition of inflammation.
    Artif Cells Nanomed Biotechnol 2018 Apr 13:1-13. Epub 2018 Apr 13.
    a Department of Ultrasound , The First Affiliated Hospital, Wenzhou Medical University , Wenzhou , Zhejiang Province , China.
    Basic fibroblast growth factor (bFGF) has shown great therapeutic effects for diabetic nephropathy (DN). However, its clinical applications are limited due to its short half-life, low stability and poor penetration. Herein, a bFGF-loaded liposome (bFGF-lip) was constructed and combined with ultrasound-targeted microbubble destruction (UTMD) to overcome these drawbacks. Read More

    FAR2 is Associated with Kidney Disease in Mice and Humans.
    Physiol Genomics 2018 Apr 13. Epub 2018 Apr 13.
    The Jackson Laboratory, The Jackson Laboratory, United States.
    Mesangial matrix expansion is an important process in the initiation of chronic kidney disease, yet the genetic factors driving its development are unknown. Our previous studies have implicated Far2 as a candidate gene associated with differences in mesangial matrix expansion between mouse inbred strains. Consistent with the hypothesis that increased expression of Far2 leads to mesangial matrix expansion through increased production of platelet-activating factor precursors, we show that FAR2 is capable of mediating de novo platelet-activating factor synthesis in vitro and driven by the transcription factor NKX3. Read More

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