34,994 results match your criteria Diabetic Nephropathy


Mouse Umbilical Cord Mesenchymal Stem Cell Paracrine Alleviates Renal Fibrosis in Diabetic Nephropathy by Reducing Myofibroblast Transdifferentiation and Cell Proliferation and Upregulating MMPs in Mesangial Cells.

J Diabetes Res 2020 2;2020:3847171. Epub 2020 May 2.

Cell Transplantation and Gene Therapy Institute, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.

Transplantation of umbilical cord mesenchymal stem cells (UC-MSCs) is currently considered a novel therapeutic strategy for diabetic nephropathy (DN). However, the mechanisms by which UC-MSCs ameliorate renal fibrosis in DN are not well understood. Herein, we firstly investigated the therapeutic effects of mouse UC-MSC infusion on kidney structural and functional impairment in streptozotocin- (STZ-) induced diabetic mice. Read More

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http://dx.doi.org/10.1155/2020/3847171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222483PMC

Autophagy and mTOR Pathways Mediate the Potential Renoprotective Effects of Vitamin D on Diabetic Nephropathy.

Int J Nephrol 2020 13;2020:7941861. Epub 2020 May 13.

Physiology Department, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Menoufia, Egypt.

Introduction: Not only is diabetic nephropathy (DN) the most common cause of end-stage renal disease worldwide, but it also increases the risk of mortality up to fourteen times compared to normoalbuminuric diabetic patients.

Aim: The aim of the current study was the evaluation of the renoprotective effects of vitamin D in DN and the possible interplay between autophagy and mTOR pathways.

Materials And Methods: Fifty male Wistar albino rats were divided (10/group) into control, DN group, insulin-treated DN group, vitamin D-treated DN group, and combined insulin and vitamin D-treated DN group. Read More

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http://dx.doi.org/10.1155/2020/7941861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243019PMC

Cyclo-RGD Truncated Polymeric Nanoconstruct with Dendrimeric Templates for Targeted HDAC4 Gene Silencing in a Diabetic Nephropathy Mouse Model.

Mol Pharm 2020 May 26. Epub 2020 May 26.

National Institute of Pharmaceutical Education and Research (NIPER) - Ahmedabad, Palaj (An Institute of National Importance), Opposite Air Force Station, Gandhinagar 382355, Gujarat, India.

Diabetic nephropathy (DN), a chronic progressive kidney disease, is a significant complication of diabetes mellitus. Dysregulation of the histone deacetylases (HDACs) gene has been implicated in the pathogenesis of DN. Hence, the HDAC-inhibitors have emerged as a critical class of therapeutic agents in DN; however, the currently available HDAC4-inhibitors are mostly nonselective in nature as well as inhibit multiple HDACs. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.0c00094DOI Listing

Uric acid in diabetic nephropathy.

J Chin Med Assoc 2020 May 20. Epub 2020 May 20.

Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.

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http://dx.doi.org/10.1097/JCMA.0000000000000349DOI Listing

Hyperpolarized [1- C] alanine production: A novel imaging biomarker of renal fibrosis.

Magn Reson Med 2020 May 25. Epub 2020 May 25.

MR Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Purpose: Renal tubulointerstitial fibrosis is strongly linked to the progressive decline of renal function seen in chronic kidney disease. State-of-the-art noninvasive diagnostic modalities are currently unable to detect the earliest changes associated with the onset of fibrosis. This study was undertaken to evaluate the potential for detecting the earliest alterations in fibrogenesis using a biofluid-based method and metabolic hyperpolarized [1- C]pyruvate imaging. Read More

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http://dx.doi.org/10.1002/mrm.28326DOI Listing

Positive interaction of mangiferin with selected oral hypoglycemic drugs: a therapeutic strategy to alleviate diabetic nephropathy in experimental rats.

Mol Biol Rep 2020 May 25. Epub 2020 May 25.

Natural Products Research Laboratory, Department of Biotechnology, Pondicherry University, R. V. Nagar, Kalapet, Puducherry, 605014, India.

Diabetic nephropathy (DN) is one of the notorious diabetes associated complications. Despite many therapeutic strategies available, metabolic control of DN continues to poses a challenge. In this study, the interactions of mangiferin with selected oral hypoglycemic drugs, metformin and gliclazide to effectively alleviate the symptoms of renal injury in DN are evaluated. Read More

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http://dx.doi.org/10.1007/s11033-020-05517-0DOI Listing

Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease.

Cell Commun Signal 2020 May 25;18(1):79. Epub 2020 May 25.

Joseph Banks Laboratories, School of Life Sciences, University of Lincoln, Green Lane, Lincoln, UK.

Background: Tubulointerstitial fibrosis represents the key underlying pathology of Chronic Kidney Disease (CKD), yet treatment options remain limited. In this study, we investigated the role of connexin43 (Cx43) hemichannel-mediated adenosine triphosphate (ATP) release in purinergic-mediated disassembly of adherens and tight junction complexes in early tubular injury.

Methods: Human primary proximal tubule epithelial cells (hPTECs) and clonal tubular epithelial cells (HK2) were treated with Transforming Growth Factor Beta1 (TGF-β1) ± apyrase, or ATPγS for 48 h. Read More

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http://dx.doi.org/10.1186/s12964-020-00558-1DOI Listing

The effects of microRNA-126 reduced inflammation and apoptosis of diabetic nephropathy through PI3K/AKT signalling pathway by VEGF.

Arch Physiol Biochem 2020 May 25:1-10. Epub 2020 May 25.

Ultrasonic Diagnosis, The First Affiliated Hospital of China Medical University, Shenyang, China.

Gene expression microarray and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to measure the expression of miR-126. In model of diabetic nephropathy, we demonstrated that miR-126 expression was down-regulated, compared with control group. Down-expression of miR-126 promoted cell apoptosis and increased inflammation (as indicated by the levels of IL-1β, IL-6, IL-18 and TNF-α) of diabetic nephropathy . Read More

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http://dx.doi.org/10.1080/13813455.2020.1767146DOI Listing

A Pre-Post Study of Vitamin D Supplements effects on Urinary megalin: The emerging predictive role of megalin in diabetic nephropathy progression.

Endocr Metab Immune Disord Drug Targets 2020 May 24. Epub 2020 May 24.

School of Pharmacy, the University of Jordan, Amman. Jordan.

Introduction: Megalin is a renal proximal tubular protein that reabsorbs vitamin D from glomerular filtrates. Previous studies found significantly higher levels of urinary megalin in chronic microvascular complications of diabetes with associated metabolic derangements. This study aimed at testing the effect of vitamin D supplements on urinary megalin levels in diabetic nephropathy (DN) patients with vitamin D hypovitaminosis. Read More

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http://dx.doi.org/10.2174/1871530320666200525012811DOI Listing

Targeting oxidative stress and anti-oxidant defence in diabetic kidney disease.

J Nephrol 2020 May 23. Epub 2020 May 23.

Department of Diabetes, Central Clinical School, Monash University, The Alfred Centre, Level 5, 99 Commercial Road, Melbourne, VIC, 3004, Australia.

There is an unmet need for new strategies to prevent or postpone the development of diabetic kidney disease. The pathophysiology of this condition includes as a central mechanism an imbalance between the excessive production of reactive oxygen species (ROS) and inadequate anti-oxidant defense. Reduction of ROS is therefore an interesting therapeutic target that warrants further investigation. Read More

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http://dx.doi.org/10.1007/s40620-020-00749-6DOI Listing

Ergosterol ameliorates renal inflammatory responses in mice model of diabetic nephropathy.

Biomed Pharmacother 2020 May 20;128:110252. Epub 2020 May 20.

Cangzhou People's Hospital, No.7 Qingchi Avenue, Xinhua District, Cangzhou 061000 Hebei, China. Electronic address:

Ergosterol (ERG) was reported to exhibit anti-inflammatory and anti-oxidative activities. Besides, ERG was found to attenuate kidney injury in the diabetic mouse. However, the protective effect of ERG in diabetic nephropathy-induced inflammation remains unclear. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110252DOI Listing

Resistant Hypertension and Risk of Adverse Events in Individuals With Type 1 Diabetes: A Nationwide Prospective Study.

Diabetes Care 2020 May 22. Epub 2020 May 22.

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.

Objective: To estimate the risk of diabetic nephropathy (DN) progression, incident coronary heart disease (CHD) and stroke, and all-cause mortality associated with resistant hypertension (RH) in individuals with type 1 diabetes stratified by stages of DN, renal function, and sex.

Research Design And Methods: This prospective study included a nationally representative cohort of individuals with type 1 diabetes from the Finnish Diabetic Nephropathy Study who had purchases of antihypertensive drugs at (±6 months) baseline visit (1995-2008). Individuals ( = 1,103) were divided into three groups: ) RH, ) uncontrolled blood pressure (BP) but no RH, and ) controlled BP. Read More

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http://dx.doi.org/10.2337/dc20-0170DOI Listing

Effects of aldose reductase inhibitors on renal blood flow parameters in patients with early diabetic nephropathy.

J Diabetes Complications 2020 May 11:107620. Epub 2020 May 11.

Department of Endocrinology, Chengyang People's Hospital in Qingdao, No.600 Changcheng Road Chengyang District, Qingdao 266109, China. Electronic address:

Objective: To investigate the changes of renal blood flow parameters in patients with early-stage diabetic nephropathy (DN) treated with Aldose reductase inhibitors (ARI)/Epalrestat.

Methods: In this prospective, 120 early DN patients aged 20-75 years from the Endocrinology Department of Chengyang District People's Hospital of Qingdao City in 2015 were randomized to intervention group including 68 patients and control group including 52 patients. Two groups of patients separately received Epalrestat and placebo for 3 months. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2020.107620DOI Listing

The association between maternal renal function and pregnancy outcomes in type 1 and type 2 diabetes.

Diabetes Res Clin Pract 2020 May 19:108225. Epub 2020 May 19.

Department of Perinatal Medicine, Mercy Health, 163 Studley Road, Heidelberg, VIC, 3084, Australia; Department of Endocrinology and Diabetes, Austin Health, 145 Studley Road, Heidelberg, VIC, 3084, Australia. Electronic address:

Aims: To investigate the prognostic value of estimated glomerular filtration rate (eGFR) and albuminuria in determining pregnancy outcomes in women with type 1 and type 2 diabetes.

Methods: An observational study of pregnant women with type 1 (n = 92) and type 2 diabetes (n = 106) who delivered between 2004 and 2014 at a single tertiary obstetric centre. Clinical and biochemical characteristics were determined and related to major obstetric outcomes: preeclampsia, preterm birth <32 and <37 weeks, and neonatal intensive care admission. Read More

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http://dx.doi.org/10.1016/j.diabres.2020.108225DOI Listing

Stroke in the patient with diabetes (Part 1) - Epidemiology, etiology, therapy and prognosis.

Diabetes Res Clin Pract 2020 May 19:108193. Epub 2020 May 19.

Southside Endocrinology, Diabetes and Thyroid Associates, Birmingham, AL. Electronic address:

There is a higher incidence of stroke in both the type 2 diabetic and the non-diabetic insulin resistant patient which is accompanied by higher morbidity and mortality. The increase in the frequency of stroke is due to an increase in cerebral infarction, mainly lacunar infarcts, with the incidence of cerebral hemorrhage being less frequent. The major risk factors for stroke in the type 2 diabetic patient are age, hypertension, the number of features of the Metabolic Syndrome, the presence of diabetic nephropathy in both the type 1 and type 2 patient, the presence of peripheral and coronary artery disease and especially the presence of atrial fibrillation. Read More

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http://dx.doi.org/10.1016/j.diabres.2020.108193DOI Listing

NADPH oxidase: A membrane-bound enzyme and its inhibitors in diabetic complications.

Eur J Pharmacol 2020 May 19:173206. Epub 2020 May 19.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V. L Mehta Road, Vile Parle (W), Mumbai, 400 056, India. Electronic address:

The human body has a mechanism for balancing the generation and neutralization of reactive oxygen species. The body is exposed to many agents that are responsible for the generation of reactive oxygen/nitrogen species, which leads to disruption of the balance between generation of these species and oxidative stress defence mechanisms. Diabetes is a chronic pathological condition associated with prolonged hyperglycaemia. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173206DOI Listing

miR-136 improves renal fibrosis in diabetic rats by targeting down-regulation of tyrosine kinase SYK and inhibition of TGF-β1/Smad3 signaling pathway.

Ren Fail 2020 Nov;42(1):513-522

Department of Kidney Transplantation, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

To investigate the way that miR-136 regulated spleen tyrosine kinase (SYK) and transforming growth factor-β1 (TGF-β1)/Smad3 signaling pathways on renal fibrosis. 100 male SD (Sprague-Dawley) rats were randomly divided into diabetic nephropathy (DN) group, normal control (NC) group, miR-136 mimics group, and control group. The renal fibrosis model of diabetic rats was established by streptozotocin (STZ) method. Read More

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http://dx.doi.org/10.1080/0886022X.2020.1764854DOI Listing
November 2020

Manipulating Sirtuin 3 pathway ameliorates renal damage in experimental diabetes.

Sci Rep 2020 May 21;10(1):8418. Epub 2020 May 21.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.

More effective treatments for diabetic nephropathy remain a major unmet clinical need. Increased oxidative stress is one of the most important pathological mechanisms that lead to kidney damage and functional impairment induced by diabetes. Sirtuin 3 (SIRT3) is the main mitochondrial deacetylase and critically regulates cellular reactive oxygen species (ROS) production and detoxification. Read More

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http://dx.doi.org/10.1038/s41598-020-65423-0DOI Listing
May 2020
5.078 Impact Factor

Inhibition of soluble epoxide hydrolase attenuates renal tubular mitochondrial dysfunction and ER stress by restoring autophagic flux in diabetic nephropathy.

Cell Death Dis 2020 May 21;11(5):385. Epub 2020 May 21.

Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Chongqing, 400042, China.

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD), and renal tubular cell dysfunction contributes to the pathogenesis of DN. Soluble epoxide hydrolase (sEH) is an enzyme that can hydrolyze epoxyeicosatrienoic acids (EETs) and other epoxy fatty acids (EpFAs) into the less biologically active metabolites. Inhibition of sEH has multiple beneficial effects on renal function, however, the exact role of sEH in hyperglycemia-induced dysfunction of tubular cells is still not fully elucidated. Read More

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http://dx.doi.org/10.1038/s41419-020-2594-xDOI Listing

Revisiting Experimental Models of Diabetic Nephropathy.

Int J Mol Sci 2020 May 19;21(10). Epub 2020 May 19.

Nephrology Research Group, Vall d'Hebrón Institut de Recerca, 08035 Barcelona, Spain.

Diabetes prevalence is constantly increasing and, nowadays, it affects more than 350 million people worldwide. Therefore, the prevalence of diabetic nephropathy (DN) has also increased, becoming the main cause of end-stage renal disease (ESRD) in the developed world. DN is characterized by albuminuria, a decline in glomerular filtration rate (GFR), hypertension, mesangial matrix expansion, glomerular basement membrane thickening, and tubulointerstitial fibrosis. Read More

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http://dx.doi.org/10.3390/ijms21103587DOI Listing

The consequences of altered microbiota in immune-related chronic kidney disease.

Nephrol Dial Transplant 2020 May 21. Epub 2020 May 21.

Division of Nephrology and Hypertension, University of California Irvine, Orange, CA, USA.

The normal gut microbiome modulates host enterocyte metabolism and shapes local and systemic immunity. Accumulation of urea and other waste products in chronic kidney disease induces gut dysbiosis and intestinal wall inflammation (leaky gut). There are decreased numbers of bacteria that generate short-chain fatty acids, which are an important nutrient source for host enterocytes and also contribute to regulation of the host immune system. Read More

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http://dx.doi.org/10.1093/ndt/gfaa087DOI Listing

Long non-coding RNA Airn protects podocytes from diabetic nephropathy lesions via binding to Igf2bp2 and facilitating translation of Igf2 and Lamb2.

Cell Biol Int 2020 May 21. Epub 2020 May 21.

Department of Endocrinology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 71004, Shaanxi, China.

Diabetic nephropathy (DN) is a severe diabetic microvascular complication with high mortality. Long non-coding RNAs (lncRNAs) are characterized as important regulators of various biological processes by emerging researches, whereas the molecular mechanisms by which lncRNAs participate in DN progression need to be further clarified. Herein, we conducted a study on the regulatory role in DN of an lncRNA named antisense of Igf2r non-protein coding RNA (Airn). Read More

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http://dx.doi.org/10.1002/cbin.11392DOI Listing

Parkin ubiquitinates GATA4 and attenuates the GATA4/GAS1 signaling and detrimental effects on diabetic nephropathy.

FASEB J 2020 May 21. Epub 2020 May 21.

Department of Nephrology, Daping Hospital, Army Medical University, Chongqing, China.

Renal tubular injury contributes to the progression of diabetic nephropathy (DN). This study explored the role and mechanisms of E3-ubiquitin ligase Parkin in the renal tubular injury of DN. We found that Parkin expression gradually decreased and was inversely associated with IL-6, TGF-β1, and GATA4 expression in the kidney during the progression of DN. Read More

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http://dx.doi.org/10.1096/fj.202000053RDOI Listing

Evaluation of the proliferative potential of skin keratinocytes and fibroblasts isolated from critical limb ischemia patients.

Regen Ther 2020 Jun 15;14:222-226. Epub 2020 May 15.

Department of Plastic and Reconstructive Surgery, International University of Health and Welfare, School of Medicine, 4-3, Kozunomori, Narita, Chiba, 286-8686, Japan.

Impaired wound healing in critical limb ischemia (CLI) results from multiple factors that affect many cell types and their behavior. Epidermal keratinocytes and dermal fibroblasts play crucial roles in wound healing. However, it remains unclear whether these cell types irreversibly convert into a non-proliferative phenotype and are involved in impaired wound healing in CLI. Read More

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http://dx.doi.org/10.1016/j.reth.2020.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229408PMC

Hospitalization costs associated with diabetic foot ulcers treated by a multidisciplinary team in clinical practice. A retrospective study from southern Turkey.

Ann Ital Chir 2020 May 14;9. Epub 2020 May 14.

Purpose: Diabetic foot ulceration (DFU) is a common problem throughout the world and results in major economic consequences for the patients and country. We aim to describe the estimated cost of illness in patients with DFU in southern Turkey.

Methods: A total of 148 (F=55, M=93) patients with DFU were included in this retrospective study. Read More

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MiR-185-3p downregulates advanced glycosylation end product receptor expression and improves renal function in diabetic nephropathy mice.

Eur Rev Med Pharmacol Sci 2020 May;24(9):5018-5027

Department of Nephrology, Weinan Central Hospital, Weinan, Shaanxi Province, China.

Objective: To investigate the effects of the downregulation of AGER by miRNA-185-3p on renal function in diabetic nephropathy (DN) mice.

Materials And Methods: Mice were divided into normal, model, NC, miR-185-3p mimic, si-AGER, and miR-185-3p mimic + si-AGER groups. Eight weeks following the establishment of the model, various indicators were assessed. Read More

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http://dx.doi.org/10.26355/eurrev_202005_21193DOI Listing

Overexpression of HOXA-AS2 inhibits inflammation and apoptosis in podocytes via sponging miRNA-302b-3p to upregulate TIMP3.

Authors:
X Li H-M Yu

Eur Rev Med Pharmacol Sci 2020 May;24(9):4963-4970

Department of Thoracic Surgery, Zhejiang Putuo Hospital, Zhoushan, China.

Objective: To clarify the role of HOXA-AS2 in the progression of diabetic nephropathy (DN) and the molecular mechanism.

Materials And Methods: Relative levels of HOXA-AS2 and microRNA-302b-3p (miRNA-302b-3p) in serum and kidney tissues of DN rats induced by STZ administration and controls were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Serum levels of interleukin-1β (IL-1β), Transforming Growth Factor-α (TNF-α), creatinine, and BUN, as well as blood glucose in DN rats administrated with vector or pcDNA-HOXA-AS2 lentivirus, were detected. Read More

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http://dx.doi.org/10.26355/eurrev_202005_21187DOI Listing

Therapeutic Effects of Fibroblast Growth Factor-21 on Diabetic Nephropathy and the Possible Mechanism in Type 1 Diabetes Mellitus Mice.

Diabetes Metab J 2020 May 15. Epub 2020 May 15.

Ruian Center of the Chinese-American Institute for Diabetic Complications, the Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Background: Fibroblast growth factor 21 (FGF21) has been only reported to prevent type 1 diabetic nephropathy (DN) in the streptozotocin-induced type 1 diabetes mellitus (T1DM) mouse model. However, the FVB (Cg)-Tg (Cryaa-Tag, Ins2-CALM1) 26OVE/PneJ (OVE26) transgenic mouse is a widely recommended mouse model to recapture the most important features of T1DM nephropathy that often occurs in diabetic patients. In addition, most previous studies focused on exploring the preventive effect of FGF21 on the development of DN. Read More

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http://dx.doi.org/10.4093/dmj.2019.0089DOI Listing

Relationship between ABO blood groups and cardiovascular disease in type 1 diabetes according to diabetic nephropathy status.

Cardiovasc Diabetol 2020 May 19;19(1):68. Epub 2020 May 19.

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.

Background: ABO blood groups have previously been associated with cardiovascular disease (CVD) in the general population. This study aimed to investigate the potential relationship between ABO blood groups and CVD in individuals with type 1 diabetes according to diabetic nephropathy (DN) status.

Methods: Adults with type 1 diabetes (4531 individuals) from the FinnDiane Study were evaluated. Read More

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http://dx.doi.org/10.1186/s12933-020-01038-zDOI Listing

The Hypoglycemic and Renal Protection Properties of Crocin Oxidative Stress-Regulated NF-κB Signaling in db/db Mice.

Front Pharmacol 2020 30;11:541. Epub 2020 Apr 30.

National Engineering Lab for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, China.

Background: As the main ingredient of . (Iridaceae) extract, crocin- I (CR) has been reported to show various pharmacological activities. The aim of this study was to investigate the hypoglycemic and renal protection properties of CR in db/db mice. Read More

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http://dx.doi.org/10.3389/fphar.2020.00541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212392PMC

Glomerulonephritis Histopathological Pattern Change.

BMC Nephrol 2020 May 18;21(1):186. Epub 2020 May 18.

Mubarak Al-Kabeer Hospital, Department of Internal Medicine, Nephrology Unit, Jabriya, Kuwait.

Background: Glomerulonephritides (GN) are relatively rare kidney diseases with substantial morbidity and mortality. They are often difficult to treat, sometimes with no cure, and can lead to chronic kidney disease (CKD) and end stage kidney disease (ESKD). Kidney biopsy is the diagnostic procedure of choice with variable indications from center to center. Read More

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http://dx.doi.org/10.1186/s12882-020-01836-3DOI Listing

Methylglyoxal-derived advanced glycation end products induce matrix metalloproteinases through activation of ERK/JNK/NF-κB pathway in kidney proximal epithelial cells.

Food Sci Biotechnol 2020 May 28;29(5):675-682. Epub 2019 Nov 28.

1Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Anam-Dong, Sungbuk-Gu, Seoul, 02841 Republic of Korea.

The accumulation of reactive α-dicarbonyl leading to advanced glycation end products (AGEs) have been linked to pathophysiological diseases in many studies, such as atherosclerosis, cataract, cancer, and diabetic nephropathy. Glycation-generated AGEs increase the expression of inflammatory cytokines by transferring signals to the cell by binding them to the receptor for AGEs (RAGE) on their cell surface. The effect of methylglyoxal-derived AGEs (AGE-4) on the induction of matrix metalloproteinases (MMPs) in rat ordinary kidney cells (NRK-52E) was explored in this research, among other AGEs. Read More

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http://dx.doi.org/10.1007/s10068-019-00704-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221093PMC

Polyclonal immunoglobulin G deposition on the tubular basement membrane in a diabetic nephropathy: A case report.

Pathol Int 2020 May 17. Epub 2020 May 17.

Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.

A 70-year-old Japanese man with diabetes mellitus was referred to our hospital for treatment of renal dysfunction. Renal biopsy revealed that the tubular basement membrane (TBM) showed extreme thickening histologically, and selective polyclonal immunoglobulin G deposition on the thickened TBM, whereas no immunoglobulin deposition was found in the glomeruli in an immunofluorescence study. In electron microscopy, a powdery type of electron dense material, which was similar to that seen in Randall-type monoclonal immunoglobulin deposition disease (MIDD), was observed on the tubular epithelial side of the TBM. Read More

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http://dx.doi.org/10.1111/pin.12940DOI Listing

Connectivity mapping of a chronic kidney disease progression signature identified lysine deacetylases as novel therapeutic targets.

Kidney Int 2020 Feb 19. Epub 2020 Feb 19.

Institute of Medical Science, University of Toronto, Toronto, Canada; Toronto General Hospital Research Institute, University Health Network, Toronto, Canada; Division of Nephrology, University Health Network, Toronto, Canada; Department of Physiology, University of Toronto, Toronto, Canada.

Tubulointerstitial injury is an important determinant of chronic kidney disease progression, yet treatment is limited. Accordingly, we derived a chronic kidney disease progression signature based on aging and disease in Col4a3 mice, a model associated with proteinuria and progressive loss of kidney function. Computational drug repurposing with the Connectivity Map identified vorinostat, a lysine deacetylase inhibitor, as a candidate treatment to reverse progression signature gene expression. Read More

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http://dx.doi.org/10.1016/j.kint.2020.01.029DOI Listing
February 2020

Hirudin reduces nephropathy microangiopathy in STZ-induced diabetes rats by inhibiting endothelial cell migration and angiogenesis.

Life Sci 2020 May 14:117779. Epub 2020 May 14.

Department of Nephropathy, Henan Provincial Hospital of Traditional Chinese Medicine, China; Department of Nephropathy, The Second Hospital Affiliated to Henan University of Chinese Medicine, China.

Objective: Kidney is the most common location of microangiopathy in diabetic patients, and we designed this study to investigate the effects of hirudin on renal microangiopathy in STZ-induced diabetes rats and in vitro.

Methods: We established a diabetes model by intraperitoneal injection of STZ and administered hirudin daily by subcutaneous injection. HE staining was used to assess kidney pathological changes. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117779DOI Listing

Esculin reduces P2X7 and reverses mitochondrial dysfunction in the renal cortex of diabetic rats.

Life Sci 2020 May 14:117787. Epub 2020 May 14.

Translational Medicine, Universidade Federal de Sao Paulo (UNIFESP-EPM), Brazil; Laboratory of Nitric Oxide and Oxidative Stress, Universidade Federal de Sao Paulo (UNIFESP-EPM), Brazil; Nephrology Division, Universidade Federal de Sao Paulo (UNIFESP-EPM), Brazil; Emergency Division, Universidade Federal de Sao Paulo (UNIFESP-EPM), Brazil.

Aims: To evaluate the effects of esculin treatment on P2X7 receptor and mitochondrial dysfunction in the renal cortex of diabetic rats.

Main Methods: Male Wistar rats, 7 weeks old, were unilaterally nephrectomized. Part of these animals were induced to diabetes using streptozotocin (60 mg/kg). Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117787DOI Listing

Association between PPARγrs1801282 polymorphism with diabetic nephropathy and type-2 diabetes mellitus susceptibility in south India and a meta-analysis.

Nefrologia 2020 May 13. Epub 2020 May 13.

Genetics Lab, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India. Electronic address:

Background: Diabetic Nephropathy (DN) is a major complication of Type 2 Diabetes Mellitus (T2DM) with high morbidity rates worldwide.

Objective: To determine the association of PPARγ rs1801282 polymorphism in T2DM and DN in south Indian population.

Methods: We have conducted a case-control study to test the association of rs1801282 polymorphism with T2DM and DN in 424 subjects (DN=128; T2DM=148 and controls=148) belonging to the south Indian population using ARMS-PCR and Sanger sequencing method. Read More

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http://dx.doi.org/10.1016/j.nefro.2020.01.005DOI Listing
May 2020
1.442 Impact Factor

Combination of naringenin and lisinopril ameliorates nephropathy in Type-1 diabetic rats.

Endocr Metab Immune Disord Drug Targets 2020 May 16. Epub 2020 May 16.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V. L. Mehta Road, Vile Parle (W), Mumbai, 400056. India.

Background: Diabetes is a metabolic disorder affecting large percentage of population worldwide. Chronic hyperglycemic condition leads to generation of advanced glycation end products, reactive oxygen species and inflammatory cytokines, which worsen functioning of kidney. Clinical management of diabetic nephropathy is difficult as it requires multifocused approach. Read More

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http://dx.doi.org/10.2174/1871530320666200516163919DOI Listing

β-Caryophyllene inhibits high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation in mesangial cells.

Int Immunopharmacol 2020 May 12;84:106556. Epub 2020 May 12.

Department of Endocrinology, Xi'an Hospital of Traditional Chinese Medicine, Xi'an 710021, Shaanxi Province, China. Electronic address:

β-Caryophyllene (BCP) is a bicyclic sesquiterpene compound that has anti-diabetic activity. However, the effect of BCP on diabetic nephropathy (DN) remains unclear. Here, we aimed to evaluate the potential role of BCP in high glucose (HG)-induced glomerular mesangial cells (MCs). Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106556DOI Listing

Therapeutic Application of Nutraceuticals in Diabetic Nephropathy: Current Evidence and Future Implications.

Diabetes Metab Res Rev 2020 May 16. Epub 2020 May 16.

Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.

Diabetes mellitus (DM) is a common metabolic disease which may cause several complications, such as diabetic nephropathy (DN). The routine medical treatments used for DM are not effective enough and have many undesirable side effects. Moreover, the global increased prevalence of DM makes researchers try to explore potential complementary or alternative treatments. Read More

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http://dx.doi.org/10.1002/dmrr.3336DOI Listing

Association of vitamin D and D with type 2 diabetes complications.

BMC Endocr Disord 2020 May 15;20(1):65. Epub 2020 May 15.

Weill Cornell Medicine-Qatar, PO Box 24144, Doha, Qatar.

Aims: Vitamin D measurement is a composite of vitamin D (25(OH)D) and D (25(OH)D) levels, and its deficiency is associated with the development of type 2 diabetes (T2DM) and diabetic complications; vitamin D deficiency may be treated with vitamin D supplements. This study was undertaken to determine if vitamin D and D levels differed between those with and without T2DM in this Middle Eastern population, and the relationship between diabetic microvascular complications and vitamin D and vitamin D levels in subjects with T2DM METHODS: Four hundred ninety-six Qatari subjects, 274 with and 222 without T2DM participated in the study. Plasma levels of total vitamin D and D were measured by LC-MS/MS analysis. Read More

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http://dx.doi.org/10.1186/s12902-020-00549-wDOI Listing
May 2020
1.673 Impact Factor

Risk Factors for Acute Renal Failure after Cardiac Catheterization Most Cited in the Literature: An Integrative Review.

Int J Environ Res Public Health 2020 May 13;17(10). Epub 2020 May 13.

Programa de Pós-Graduação em Epidemiologia e Vigilância em Saúde (PPGEVS), Instituto Evandro Chagas (IEC), Ananindeua 67030-000, Brazil.

Acute renal failure (ARF) represents 17% of the complications of cardiac catheterization (CC), with a high death rate and longer hospitalization time. The objective of this review is to describe the most cited risk factors for acute kidney failure in the literature. It is a descriptive and exploratory Integrative Literature Review (ILR) with a qualitative approach, using articles published in the Latin American and Caribbean Health Sciences Literature (LILACS) and PubMed databases between the years of 2009 and 2019 in English, Portuguese, and Spanish, including original articles, reviews, and case studies. Read More

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http://dx.doi.org/10.3390/ijerph17103392DOI Listing

The Interplay of Renin-Angiotensin System and Toll-Like Receptor 4 in the Inflammation of Diabetic Nephropathy.

J Immunol Res 2020 30;2020:6193407. Epub 2020 Apr 30.

Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Diabetic nephropathy (DN) is one of the most serious chronic kidney diseases and the major cause of end-stage renal failure worldwide. The underlying mechanisms of DN are complex and required to be further investigated. Both innate immunity and renin-angiotensin system (RAS) play critical roles in the pathogenesis of DN. Read More

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http://dx.doi.org/10.1155/2020/6193407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210546PMC

Research Progress on the Role of Inflammasomes in Kidney Disease.

Mediators Inflamm 2020 29;2020:8032797. Epub 2020 Jan 29.

Department of Nephrology, Chinese PLA General Hospital, Medical School of Chinese PLA, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, 28 Fuxing Road, Beijing 100853, China.

Inflammasomes are multimeric complexes composed of cytoplasmic sensors, apoptosis-associated speck-like protein containing a caspase activation and recruitment domain (ASC or PYCARD), and procaspase-1 and play roles in regulating caspase-dependent inflammation and cell death. Inflammasomes are assembled by sensing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) and initiate inflammatory responses by activating caspase-1. Activated caspase-1 promotes the release of the inflammatory cytokines interleukin-1 (IL-1) and IL-18 and eventually induces pyroptosis. Read More

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http://dx.doi.org/10.1155/2020/8032797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204206PMC
January 2020

New Insights into the Pathogenesis of Diabetic Nephropathy: Proximal Renal Tubules Are Primary Target of Oxidative Stress in Diabetic Kidney.

Acta Histochem Cytochem 2020 Apr 25;53(2):21-31. Epub 2020 Apr 25.

Department of Molecular Pathology, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791-0295, Japan.

Diabetic nephropathy is a major source of end-stage renal failure, affecting about one-third cases of diabetes mellitus. It has long been accepted that diabetic nephropathy is mainly characterized by glomerular defects, while clinical observations have implied that renal tubular damage is closely linked to kidney dysfunction at the early stages of diabetic nephropathy. In this study, we conducted pathohistological analyses focusing on renal tubular lesions in the early-stage diabetic kidney with the use of a streptozotocin (STZ)-induced diabetes mellitus mouse model. Read More

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http://dx.doi.org/10.1267/ahc.20008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212204PMC

Canagliflozin for the Treatment of Diabetic Kidney Disease and Implications for Clinical Practice: A Narrative Review.

Diabetes Ther 2020 May 13. Epub 2020 May 13.

Clinica La Esperanza, Albuquerque, NM, USA.

Type 2 diabetes mellitus (T2DM) affects millions of people worldwide, elevating their risk of developing a range of complications, including chronic kidney disease (CKD). People with T2DM and CKD (i.e. Read More

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http://dx.doi.org/10.1007/s13300-020-00826-wDOI Listing

Umbilical Cord-Derived Mesenchymal Stem Cells Ameliorate Nephrocyte Injury and Proteinuria in a Diabetic Nephropathy Rat Model.

J Diabetes Res 2020 29;2020:8035853. Epub 2020 Apr 29.

Department of Biochemistry and Molecular Biology, Wuhan University School of Basic Medical Sciences, Wuhan, China.

Mesenchymal stem cells (MSCs) are shown to alleviate renal injury of diabetic nephropathy (DN) in rats. However, the underlying mechanism of this beneficial effect is not fully understood. The aims of this study are to evaluate effects of umbilical cord-derived mesenchymal stem cells (UC-MSCs) on renal cell apoptosis in streptozotocin- (STZ-) induced diabetic rats and explore the underlying mechanisms. Read More

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http://dx.doi.org/10.1155/2020/8035853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206880PMC

The potential role of lncRNAs in diabetes and diabetic microvascular complications.

Endocr J 2020 May 12. Epub 2020 May 12.

Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, PR China.

Long noncoding RNAs (lncRNAs) are a group of noncoding RNAs that are longer than 200 nucleotides without protein-coding potential. Becasuse of which these RNAs have no significant protein-coding potential, they were initially considered as "junk-products" of transcription without biological meaning. Nevertheless, recent research advancements have shown that lncRNAs are involved in many physiological processes such as cell cycle regulation, cell apoptosis and survival, cancer migration and metabolism. Read More

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http://dx.doi.org/10.1507/endocrj.EJ19-0574DOI Listing

Use of Glycated Hemoglobin (A1c) as a Biomarker for Vascular Risk in Type 2 Diabetes: Its Relationship with Matrix Metalloproteinases-2, -9 and the Metabolism of Collagen IV and Elastin.

Medicina (Kaunas) 2020 May 11;56(5). Epub 2020 May 11.

Department of Biology, Medical University-Pleven, 1 Kliment Ohridski Str., 5800 Pleven, Bulgaria.

: HbA1c measurements may be useful not only in optimizing glycemic control but also as a tool for managing overall vascular risk in patients with diabetes. In the present study, we investigate the clinical significance of HbA1c as a biomarker for hyperglycemia-induced vascular damages in type 2 diabetes (T2D) based on the levels of matrix metalloproteinases-2, -9 (MMP-2, MMP-9), anti-collagen IV (ACIV), and anti-elastin (AE) antibodies (Abs) IgM, IgG, and IgA, and CIV-derived peptides (CIV-DP) reflecting collagen and elastin turnover in the vascular wall. The aim is to show the relationship of hyperglycemia with changes in the levels of vascular markers and the dynamics of this relationship at different degrees of glycemic control reported by HbA1c levels. Read More

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http://dx.doi.org/10.3390/medicina56050231DOI Listing

Pre-procedural hyperglycemia increases the risk of contrast-induced nephropathy in patients undergoing coronary angiography: A systematic review and meta-analysis.

Cardiovasc Revasc Med 2020 May 4. Epub 2020 May 4.

Division of Cardiovascular Medicine, Keck School of Medicine of University of Southern California, CA, USA.

Background: Contrast-induced nephropathy (CIN) frequently occurs following coronary angiography (CAG) and is associated with worse outcomes, including both short and long-term mortality. Previous studies reported an association between procedural hyperglycemia (PH) and CIN, with or without diabetes mellitus (DM). We performed a systematic review and meta-analysis to explore the association of PH and CIN in patients undergoing CAG. Read More

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http://dx.doi.org/10.1016/j.carrev.2020.04.040DOI Listing