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J Assoc Physicians India 2022 May;70(5):11-12

Assistant Professor, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana.

Objectives: To determine the association of eNOS (T786C and 27bp VNTR) gene polymorphism with the risk of type II diabetes mellitus and diabetic nephropathy in North India.

Methods: The prospective case control study was conducted over a period of 18 months. A total of 100 patients of Type 2 Diabetes Mellitus (A1: 50 cases without Diabetic nephropathy-DN and 50 cases with DN) aged 18-75 years and 50 healthy adults as control (Group B) were included. Read More

J Assoc Physicians India 2022 May;70(5):11-12

Professor Rtd., Indira Gandhi Medical College, Shimla, Himachal Pradesh.

Introduction: Diabetic retinopathy, the diabetes-specific long-term microvascular complication is an important predictor of diabetic nephropathy. Diabetes induced retinopathy mostly proceeds nephropathy in patients with Type1 diabetes; however, this sequence is not consistent in patients with Type 2 diabetes and has significant discordance.

Methods: It was a hospital-based prospective, observational study conducted at Indira Gandhi Medical College, Shimla Himachal Pradesh a tertiary care center in the sub-Himalayan region of India from July 2016 to June 2017. Read More

Vopr Pitan 2022 14;91(2):58-71. Epub 2022 Mar 14.

Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.

Insufficient vitamin content in the diet is a risk factor for the development of various diseases and their progression, and drug therapy can also contribute to the development of a deficiency of these micronutrients. Data on vitamin sufficiency of patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) are needed to develop measures to improve it. of the research was to compare vitamin status of patients with T2DM without DN and those with T2DM complicated by nephropathy by assessing vitamin blood level and urinary excretion. Read More

Health Qual Life Outcomes 2022 May 20;20(1):81. Epub 2022 May 20.

School of Health Science, Mae Fah Luang University, 333 Moo 1, Ta Sud Subdistrict, Muang District, 57100, Chiang Rai Province, Thailand.

Background: Quality of life (QOL) is a good indicator of lifespan, especially for individuals who are suffering from a particular illness. QOL among patients with diabetes mellitus (DM) could be used for further implementations in addition to improving patient care and disease management, especially during the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to assess QOL and identify factors associated with a good QOL among DM patients in northern Thailand. Read More

Mol Med 2022 May 20;28(1):58. Epub 2022 May 20.

Department of Traditional Chinese Medicine, Huizhou Municipal Central Hospital, Huicheng District, No. 41 Eling North Road, Huizhou, 516000, Guangdong, China.

Background: Glabridin (Glab) is a bioactive component of licorice that can ameliorate diabetes, but its role in diabetic nephropathy (DN) has seldom been reported. Herein, we explored the effect and underlying mechanism of Glab on DN.

Methods: The bioactive component-target network of licorice against DN was by a network pharmacology approach. Read More

BMC Endocr Disord 2022 May 20;22(1):135. Epub 2022 May 20.

Chronic Care and Family Nursing, Division of Nursing Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-Ku, Hiroshima, 734-8553, Japan.

Background: Existing reviews indicated that disease management for patients with diabetes may be effective in achieving better health outcomes with less resource utilization in the short term. However, the long-term results were inconsistent because of the heterogeneous nature of the study designs. In the present study, we evaluated the 5-year follow-up results of a local disease management program focused on diabetic nephropathy prevention under the universal public health insurance scheme in Japan. Read More

J Clin Endocrinol Metab 2022 May 20. Epub 2022 May 20.

Department of Translational and Precision Medicine, Sapienza University of Rome, Italy.

Aim: To evaluate early, before the onset of cardiovascular events and of chronic renal insufficiency, the association between CKD-mineral bone disorder biomarkers and vascular stiffness (Cardio Ankle Vascular Index, CAVI) in the course of type 2 diabetes (T2DM).

Method: we evaluated 174 T2DM patients (median age 56 y; M/F = 100/74) with diabetes duration less than 10 years and without decreased glomerular filtration rate (eGFR ≥60 ml/min/1.73 m 2) or macrovascular complications. Read More

Nutr Rev 2022 May 20. Epub 2022 May 20.

Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil.

Context: Polyphenols have antioxidant, anti-inflammatory, and anti-glycation properties.

Objective: To assess the effects of dietary polyphenols, from food sources or supplements, on the anthropometric, glycemic, renal, inflammatory, and oxidative stress markers in adults with diabetic nephropathy (DN).

Data Sources: Systematic searches for randomized clinical trials were performed in MEDLINE, Embase, CENTRAL, Web of Science, LILACS, SciELO, opengrey. Read More

Biomed Res Int 2022 10;2022:9554658. Epub 2022 May 10.

Department of Pathology, Hebei Medical University, Shijiazhuang 050017, China.

Diabetic nephropathy is a leading cause of end-stage renal disease in both developed and developing countries. It is lack of specific diagnosis, and the pathogenesis remains unclarified in diabetic nephropathy, following the unsatisfactory effects of existing treatments. Therefore, it is very meaningful to find biomarkers with high specificity and potential targets. Read More

Metabolism 2022 May 16;132:155218. Epub 2022 May 16.

Department of Molecular Biology and Genetics, Aarhus University, DK-8000 Aarhus C, Denmark. Electronic address:

Background: Diabetic nephropathy (DN) is a serious complication of diabetes and a common cause of end stage renal failure. Insulin-like growth factor (IGF)-signaling has been implicated in DN, but is mechanistically poorly understood. Here, we assessed the activity of the metalloproteinase PAPP-A, an activator of IGF activity, and its possible interaction with the endogenous PAPP-A inhibitors stanniocalcin (STC)-1 and -2 in the mammalian kidney under normal and hyperglycemic conditions. Read More

J Diabetes Res 2022 9;2022:9632355. Epub 2022 May 9.

Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, China.

Objective: Emerging evidence demonstrates that vitamin D status contributes to the incidence of diabetic kidney disease (DKD). However, the causal relationships between vitamin D and mortality among individuals with DKD are inconclusive. Our study is aimed at exploring the relationship between serum 25-hydroxyvitamin D (25(OH)D) concentrations and mortality among adults with DKD. Read More

Diabetes Metab J 2022 May 10. Epub 2022 May 10.

Department of Epidemiology, School of Public Health, Southern Medical University (Guangdong Provincial Key Laboratory of Tropical Disease Research), Guangzhou, China.

Background: Obesity is associated with adverse health events among diabetic patients, however, the relationship between obesity fluctuation and risk of microvascular complications among this specific population is unclear. We aimed to examine the effect of waist circumference (WC) and body mass index (BMI) variability on the risk of diabetic microvascular outcome.

Methods: Annually recorded anthropometric data in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study was used to examine the association of WC and BMI variability defined as variability independent of mean, with the risk of microvascular outcomes, including neuropathy, nephropathy, and retinopathy. Read More

Food Funct 2022 May 18. Epub 2022 May 18.

Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Obesity is an extensive health problem worldwide that is frequently associated with diabetes. It is a risk factor for the development of several diseases including diabetic nephropathy. Recent studies have reported that gut dysbiosis aggravates the progression of obesity and diabetes by increasing the production of uremic toxins in conjunction with gut barrier dysfunction which then leads to increased passage of lipopolysaccharides (LPS) into the blood circulatory system eventually causing systemic inflammation. Read More

Hum Cell 2022 May 18. Epub 2022 May 18.

Department of Ophthalmology, First Affiliated Hospital of Kunming Medical University, Kunming Medical University, No. 295, Xichang Road, Kunming, 650032, Yunnan, China.

Diabetic nephropathy is one of the most important chronic microvascular complications of diabetes, and its main feature is diabetic glomerulosclerosis. Endothelial sirtuin 1 (SIRT1) expression is related to aging, and reducing SIRT1 expression promotes endothelial cell aging. Plasminogen activator inhibitor-1 (PAI-1) can be synthesized in a variety of cells, such as endothelial cells. Read More

Medicine (Baltimore) 2022 May 13;101(19):e29152. Epub 2022 May 13.

Changchun University of Chinese Medicine, 1035 Bo Shuo Road, Changchun City, Jilin Province, China.

Background: Diabetic nephropathy (DN) is one of the most serious complications of diabetes. It has become a global public health problem among humans. DN is the leading cause of end-stage renal disease. Read More

Nephrol Dial Transplant 2022 May 18. Epub 2022 May 18.

Servicio de Nefrologia Hospital Arnau de Vilanova, Lleida.

Background: Kidney biopsies of patients with diabetic nephropathy (DN) and normal kidney function may exhibit interstitial fibrosis (IF) without reduction of glomerular filtration rate because of hyperfiltration. The aim of our study was to analyze the performance of a set of biomarkers of tubular injury to estimate the extent of IF in patients with DN and normal kidney function.

Patients And Methods: This cross-sectional study included 118 adults with DN diagnosed by kidney biopsy and GFR ≥ 90 mL/min/1. Read More

Environ Toxicol 2022 May 18. Epub 2022 May 18.

Cardiovascular and Mitochondria Related Diseases Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

Diabetic nephropathy is a serious chronic complication affecting at least 25% of diabetic patients. Hyperglycemia associated advanced glycation end-products (AGEs) increase tubular epithelial-myofibroblast transdifferentiation (TEMT) and extracellular matrix synthesis and thereby causes renal fibrosis. The chalcone isoliquiritigenin, found in many herbs of Glycyrrhiza family, is known for potential health-promoting effects. Read More

Foot Ankle Int 2022 May 18:10711007221088552. Epub 2022 May 18.

Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Background: Diabetic foot osteomyelitis (DFO) often leads to amputations in the lower extremity. Data on the influence of the initial anatomical DFO localization on ultimate major amputation are limited.

Methods: In this retrospective analysis, 583 amputation episodes in 344 patients (78 females, 266 males) were analyzed. Read More

World J Diabetes 2022 Apr;13(4):358-375

Department of Nephrology, Shenzhen University General Hospital, Shenzhen 518000, Guangdong Province, China.

Background: NLRP3-mediated pyroptosis is recognized as an essential modulator of renal disease pathology. Long noncoding RNAs (lncRNAs) are active participators of diabetic nephropathy (DN). X inactive specific transcript (XIST) expression has been reported to be elevated in the serum of DN patients. Read More

Diabetes Res Clin Pract 2022 May 14:109926. Epub 2022 May 14.

NHMRC Clinical Trials Centre, The University of Sydney, Sydney, NSW, Australia.

Aims: We aimed to determine how white blood cell (WBC) telomeres and telomere length change over time are associated with health status in type 1 diabetes.

Methods: Relative telomere length (rTL) was measured in WBC DNA from two time-points (median 6.8 years apart) in 618 individuals from the Finnish Diabetic Nephropathy Study by quantitative PCR, with interassay CV ≤4%. Read More

Gan To Kagaku Ryoho 2022 May;49(5):585-587

Dept. of Surgery, Ageo Central General Hospital.

A 66-year-old man was referred to our department with the diagnosis of ascending colon cancer. He was undergoing dialysis for chronic renal failure due to diabetic nephropathy. Laparoscopic ileocecal resection was planned for the ascending colon cancer, but the procedure was converted to laparotomy owing to intraoperative bleeding. Read More

Bioengineered 2022 May;13(5):12224-12236

Department of Endocrinology, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian, China.

Diabetic nephropathy (DN) is a microvascular disease caused by diabetes. Tanshinone IIA has been indicated to ameliorate streptozotocin-induced DN. This study explores the effect of tanshinone IIA on high glucose-induced renal tubular epithelial cell pyroptosis and inflammation. Read More

Endocrinol Metab (Seoul) 2022 May 16. Epub 2022 May 16.

Department of Gastroenterology, Kidney Disease and Hemodialysis Center, Shaanxi Provincial People's Hospital, Xi'an, China.

Background: This study investigated the effect of short-chain fatty acids (SCFAs) on diabetes in a mouse model.

Methods: Autophagy in Akita mice and streptozocin (STZ)-induced diabetic C57BL/6 mice was determined by Western blots and immunohistochemistry (IHC). Western blots, IHC, hematoxylin and eosin staining, Masson staining, periodic acid-Schiff staining, and picrosirius red staining were conducted to detect whether autophagy and renal function improved in Akita mice and STZ-induced diabetic C57BL/6 mice after treatment of SCFAs. Read More

J Adv Res 2022 05 18;38:119-129. Epub 2021 Aug 18.

Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Al Abdeyah, PO Box 7607, Makkah, Saudi Arabia.

Introduction: Although the synthetic vitamin D analogue, Paricalcitol, and omega-3 Fatty acids (ω-3) alleviated diabetic nephropathy (DN), their combination was not previously explored.

Objectives: This study measured the potential ameliorative effects of single and dual therapies of Paricalcitol and/or ω-3 against DN.

Methods: Forty rats were assigned as follow: negative (NC) and positive (PC) controls, Paricalcitol, ω-3 and Paricalcitol + ω-3 groups. Read More

Kidney Int Rep 2022 May 14;7(5):1004-1015. Epub 2022 Feb 14.

Division of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany.

Introduction: Prospective data on impact of educational attainment on prognosis in patients with chronic kidney disease (CKD) are scarce. We investigated the association between educational attainment and all-cause mortality, major adverse cardiovascular (CV) events (MACEs), kidney failure requiring dialysis, and CKD etiology.

Methods: Participants ( = 5095, aged 18-74 years) of the ongoing multicenter German Chronic Kidney Disease (GCKD) cohort, enrolled on the basis of an estimated glomerular filtration rate (eGFR) of 30 to 60 ml/min (stages G3, A1-A3) or overt proteinuria (stages G1-G2, A3), were divided into 3 categories according to their educational attainment and were followed for 6. Read More

Eur J Pharmacol 2022 May 12:175022. Epub 2022 May 12.

Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Army Medical University, Chongqing, 400038, China; Chongqing Engineering Research Center for Pharmacodynamics Evaluation, College of Pharmacy, Army Medical University, Chongqing, 400038, China. Electronic address:

Phillyrin, a well-known natural compound from the dried fruits of Forsythia suspensa (Thunb.) Vahl., has shown anti-inflammatory, antioxidant and anti-virus activities as well as renal protective effects on diabetic nephropathy. Read More

Biochem Biophys Res Commun 2022 May 6;614:63-69. Epub 2022 May 6.

Department of Nephropathy and Hemodialysis, First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin, Heilongjiang Province, 150000, China. Electronic address:

Inflammation and glomerular endothelial dysfunction promote diabetic kidney disease (DKD) progression, but the mechanisms are not fully understood. Allograft inflammatory factor-1 (AIF-1) is a protein that regulates inflammatory reactions and immune responses. This study aimed to explore the mechanism of AIF-1 in a DKD animal model and mouse renal glomerular endothelial cells (MRGECs). Read More

Appl Biochem Biotechnol 2022 May 14. Epub 2022 May 14.

Department of Kidney Disease Unit & Dialysis, Central Hospital Affiliated to Shandong First Medical University, No. 105, Jiefang Road, Jinan City, Shandong, 250013, China.

Diabetes is an amalgamation of metabolic disorders marked by hyperglycemia. Over time diabetes brings up several other complications with it like cardiovascular disease, retinopathy, neuropathy, and nephropathy. among which diabetic nephropathy (DN) is the one we are concerned about in the present study. Read More

J Clin Med 2022 May 6;11(9). Epub 2022 May 6.

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.

Background: The distal ulnar-basilic arteriovenous fistula (UBAVF) is a rarely used alternative type of vascular access for haemodialysis. The location of the vein on the back aspect of the forearm forces an extremely uncomfortable external rotation of the upper limb during surgery when the patient is in a supine position.

Methods: We present a new approach towards creating UBAVF, which involves placing the patient in the prone position, thus eliminating the aforementioned inconvenience. Read More

Molecules 2022 Apr 21;27(9). Epub 2022 Apr 21.

Department of Internal Medicine II, Division of Nephrology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.

Considering the valuable information provided by glycosphingolipids as molecular markers and the limited data available for their detection and characterization in patients suffering from Type 2 diabetic kidney disease (DKD), we developed and implemented a superior method based on high-resolution (HR) mass spectrometry (MS) and tandem MS (MS/MS) for the determination of gangliosides in the urine of DKD patients. This study was focused on: (i) testing of the HR MS and MS/MS feasibility and performances in mapping and sequencing of renal gangliosides in Type 2 DM patients; (ii) determination of the changes in the urine gangliosidome of DKD patients in different stages of the disease-normo-, micro-, and macroalbuminuria-in a comparative assay with healthy controls. Due to the high resolution and mass accuracy, the comparative MS screening revealed that the sialylation status of the ganglioside components; their modification by -acetyl, CHCOO, -fucosyl, and -GalNAc; as well as the composition of the ceramide represent possible markers for early DKD detection, the assessment of disease progression, and follow-up treatment. Read More