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    Normoalbuminuric diabetic kidney disease.
    Front Med 2017 Jul 18. Epub 2017 Jul 18.
    Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha, 410011, China.
    Diabetic kidney disease (DKD) is one of the primary causes of end-stage renal disease (ESRD). Early diagnosis is very important in preventing the development of DKD. Urinary albumin excretion rate (UAER) and glomerular filtration rate (GFR) are widely accepted as criteria for the diagnosis and clinical grading of DKD, and microalbuminuria has been recommended as the first clinical sign of DKD. Read More

    Preparation of exenatide-loaded linear poly(ethylene glycol)-brush poly(l-lysine) block copolymer: potential implications on diabetic nephropathy.
    Int J Nanomedicine 2017 29;12:4663-4678. Epub 2017 Jun 29.
    Department of Pathology and Pathophysiology, Provincial Key Discipline of Pharmacology, Jiaxing University Medical College, Jiaxing, Zhejiang, People's Republic of China.
    The poly(ethylene glycol)-b-brush poly(l-lysine) polymer (PEG-b-(PELG50-g-PLL3)) was synthesized and evaluated as a nanocarrier for prolonging delivery of exenatide through the abdominal subcutaneous injection route. The isoelectric point of exenatide was 4.86, and exenatide could combine with PEG-b-(PELG50-g-PLL3) polymers via electrostatic interactions at pH 7. Read More

    Visualization of kidney fibrosis in diabetic nephropathy by long diffusion tensor imaging MRI with spin-echo sequence.
    Sci Rep 2017 Jul 18;7(1):5731. Epub 2017 Jul 18.
    Department of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0781, Japan.
    Renal fibrosis (RF) is an indicator for progression of chronic kidney disease (CKD). Although diabetic nephropathy (DN) is the leading cause of CKD and end-stage renal disease in Western populations, the ability of MRI to evaluate RF in DN patients has not been determined. As a first step to identify possible MRI methods for RF evaluation, we examined the use of diffusion tensor imaging (DTI) MRI to evaluate RF in a rat model of DN (SHR/NDmcr-cp(cp/cp): SHR/ND). Read More

    Cdc42-Interacting Protein 4 silencing relieves pulmonary fibrosis in STZ-induced diabetic mice via the Wnt/GSK-3β/β-catenin pathway.
    Exp Cell Res 2017 Jul 15. Epub 2017 Jul 15.
    The Second Department of Handsurgery and Microsurgery, Zhengzhou Orthopaedics Hospital, Zhengzhou, 450052, Henan, China.
    Cdc42-interacting protein-4 (CIP4) has been reported to be closely associated with diabetic nephropathy in rat. However, little is known about the correlation between CIP4 and diabetic pulmonary fibrosis (PF) in mice. Here, diabetes was induced by streptozotocin (STZ), and later lung tissue was collected and subjected to hematoxylin and eosin (H & E) staining for morphological examination. Read More

    Crocin Protects Podocytes Against Oxidative Stress and Inflammation Induced by High Glucose Through Inhibition of NF-κB.
    Cell Physiol Biochem 2017 Jul 18;42(4):1481-1492. Epub 2017 Jul 18.
    Department of Nephropathy, Xi'an, China.
    Background/aims: Diabetic nephropathy (DN) is a microangiopathic disease characterized by excessive urinary albumin excretion, which occurs in 30% of patients with diabetes mellitus. It is the second leading cause of end-stage renal diseases in China. Nuclear factor-kappa B (NF-κB) is reported to be closely correlated with the inflammation underlying diabetes-associated renal damage. Read More

    Progression of skin autofluorescence of AGEs over 4 years in patients with type 1 diabetes.
    Diabetes Metab Res Rev 2017 Jul 18. Epub 2017 Jul 18.
    Nutrition Diabetology Unit, CHU Bordeaux, Haut Lévêque Hospital, Pessac, France.
    Background: The deposit of Advanced Glycation End-products (AGEs) is involved in diabetic complications. It can be evaluated by measuring the skin autofluorescence (sAF). We searched whether sAF progressed over 4 years in Type 1 Diabetes, and analysed its relationship with the development of nephropathy. Read More

    Comparative efficacy and safety of gemigliptin versus linagliptin in type 2 diabetes patients with renal impairment: A 40-week extension of the GUARD randomized study.
    Diabetes Obes Metab 2017 Jul 18. Epub 2017 Jul 18.
    Korea University Ansan Hospital, Ansan, Republic of Korea.
    Aims: The present extension study evaluated the long-term safety and efficacy of gemigliptin during a 40-week follow-up period after a 12-week study.

    Methods: The main study was a randomized, placebo-controlled, double-blinded, phase IIIb study in which 50 mg of gemigliptin (N = 66) or placebo (N = 66) was administered to patients with type 2 diabetes mellitus (T2DM) with moderate or severe renal impairment over a 12-week period. Patients with a glycated haemoglobin (HbA1c) level of 7-11% and an estimated glomerular filtration rate (eGFR) of 15-59 mL/min/1. Read More

    Active subfractions of Abelmoschus esculentus substantially prevent free fatty acid-induced β cell apoptosis via inhibiting dipeptidyl peptidase-4.
    PLoS One 2017 17;12(7):e0180285. Epub 2017 Jul 17.
    Division of Basic Medical Science, Hungkuang University, Shalu District, Taichung, Taiwan.
    Lipotoxicity plays an important role in exacerbating type 2 diabetes mellitus (T2DM) and leads to apoptosis of β cells. Recently dipeptidyl peptidase-4 (DPP-4) inhibitors have emerged as a useful tool in the treatment of T2DM. DPP-4 degrades type 1 glucagon-like peptide (GLP-1), and GLP-1 receptor (GLP-1R) signaling has been shown to protect β cells by modulating AMPK/mTOR, PI3K, and Bax. Read More

    Biorhizome: A Biosynthetic Platform for Colchicine Biomanufacturing.
    Front Plant Sci 2017 30;8:1137. Epub 2017 Jun 30.
    College of Agriculture and Technology, Arkansas State University, JonesboroAR, United States.
    Colchicine is one of the oldest plant-based medicines used to treat gout and one of the most important alkaloid-based antimitotic drugs with anticancer potential, which is commercially extracted from Gloriosa superba. Clinical trials suggest that colchicine medication could prevent atrial fibrillation recurrence after cardiac surgery. In addition, therapeutic colchicine is undergoing clinical trials to treat non-diabetic metabolic syndrome and diabetic nephropathy. Read More

    MRTF-A mediated FN and ICAM-1 expression in AGEs-induced rat glomerular mesangial cells via activating STAT5.
    Mol Cell Endocrinol 2017 Jul 13. Epub 2017 Jul 13.
    Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou 510006, China; Guangdong Provincial Engineering & Technology Research Center for Disease-Model Animals, Guangzhou 510006, China. Electronic address:
    Advanced glycation end products (AGEs), formed at an accelerated rate under diabetes, play a role in inflammation and fibrosis in mesangial areas in diabetic nephropathy (DN). However, the transcriptional modulator that mediates the cellular response to AGEs remains largely obscure. Our goal was to determine whether myocardin-related transcription factor (MRTF)-A, a key protein involved in the transcriptional regulation of smooth muscle cell phenotype, was responsible for the glomerular mesangial cells (GMCs) injury by AGEs, and, if so, how MRTF-A promoted mesangial dysfunction initiated by AGEs. Read More

    Plasma high-sensitivity troponin T predicts end-stage renal disease and cardiovascular and all-cause mortality in patients with type 1 diabetes and diabetic nephropathy.
    Kidney Int 2017 Jul 13. Epub 2017 Jul 13.
    Steno Diabetes Center Copenhagen, Gentofte, Denmark; HEALTH, University of Aarhus, Aarhus, Denmark; Institute for Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
    High-sensitivity troponin T (hsTnT) is a marker of cardiovascular disease (CVD) and in type 2 diabetes also a marker of renal events, but has not been evaluated in type 1 diabetics. We therefore reviewed a type 1 diabetes cohort of 442 without and 458 with diabetic nephropathy. Baseline samples were analyzed for hsTnT levels. Read More

    Discovery of a potent angiotensin converting enzyme inhibitor via virtual screening.
    Bioorg Med Chem Lett 2017 Jul 5. Epub 2017 Jul 5.
    State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Pharmaceutical Co., Ltd., Jiangsu, Lianyungang 222001, China. Electronic address:
    Prompted by the prominent role of angiotensin converting enzyme (ACE) in hypertension, heart failures, myocardial infarction and diabetic nephropathy, we have attempted to discover novel ACE inhibitors through ligand-based virtual screening. Molecular docking method and rigorously validated model was utilized to search a natural compounds database. Finally, 36 compounds were randomly selected and subjected to in vitro ACE kinase inhibitory assay using fluorescence assays method. Read More

    Diabetic Nephropathy and Pregnancy.
    Semin Nephrol 2017 Jul;37(4):362-369
    Division of Transplantation and Mucosal Biology, King's College London, London, UK. Electronic address:
    Women with diabetic nephropathy have challenging pregnancies, with pregnancy outcomes far worse than expected for the stage of chronic kidney disease. The underlying mechanisms that cause the adverse events remain poorly understood, but it is a widely held belief that substantial endothelial injury in these women likely contributes. Maternal hypertension, preeclampsia, and cesarean section rates are high, and offspring are often preterm and of low birth weight, with additional neonatal complications associated with glycemic control. Read More

    Renal Allograft Histology at 10 Years after Transplantation in the Tacrolimus Era: Evidence of Pervasive Chronic Injury.
    Am J Transplant 2017 Jul 15. Epub 2017 Jul 15.
    Departments of Surgery and Immunology (MDS, WDP), Laboratory Medicine and Pathology (LDC), Biostatics (BHS) and Medicine (FGC), Mayo Clinic, Rochester, Minnesota, USA.
    Improving long-term renal allograft survival remains an important unmet need. To assess the extent of histologic injury at 10 years after transplantation in functioning grafts, we studied 575 consecutive adult solitary renal transplants performed between 2002 and 2005-77% from living donors and 92% maintained on tacrolimus-based immunosuppression. Ten-year graft survival was 59% and death-censored graft survival was 74%. Read More

    Pioglitazone ameliorates glomerular NLRP3 inflammasome activation in apolipoprotein E knockout mice with diabetes mellitus.
    PLoS One 2017 14;12(7):e0181248. Epub 2017 Jul 14.
    Department of cardiology, the affiliated hospital of Yangzhou University (Yangzhou NO.1 people's hospital), Yangzhou University, Yangzhou, Jiangsu, China.
    Objective: The NLRP3 inflammasome plays an important role in the pathogenesis of inflammation in diabetic nephropathy (DN). Pioglitazone (PIO) has been found to exert an anti-inflammatory effect in patients with diabetes mellitus, but it is still unclear whether PIO exhibits a similar effect in DN. We aimed to explore the effect and underlying mechanism of PIO on DN, as well as investigate if NLRP3 is a pharmacologic target of PIO. Read More

    Down-regulation of miR-23a inhibits high glucose-induced EMT and renal fibrogenesis by up-regulation of SnoN.
    Hum Cell 2017 Jul 13. Epub 2017 Jul 13.
    Urology Department, Cangzhou Central Hospital, No. 16 Xinhua Road, Hebei, 061000, People's Republic of China.
    It has been reported that transforming growth factor-β1 (TGF-β1) signaling plays an important role in the development of diabetic nephropathy (DN). The nuclear transcription co-repressor Ski-related novel protein N (SnoN) is a critical negative regulator of TGF-β1/Smad signal pathway, involving in tubule epithelial-mesenchymal transition (EMT), extracellular matrix (ECM) accumulation, and tubulointerstitial fibrosis. In this study, we focused on miR-23a as a regulator of SnoN. Read More

    Acute Fulminant Uremic Neuropathy Following Coronary Angiography Mimicking Guillain-Barre Syndrome.
    Heart Views 2017 Apr-Jun;18(2):62-63
    Department of Cardiology, JLN Hospital, Ajmer, Rajasthan, India.
    A 55-year-old diabetic woman suffered a posterior wall ST-elevation myocardial infarction. She developed contrast-induced nephropathy following coronary angiography. Acute fulminant uremic neuropathy was precipitated which initially mimicked Guillan-Barre Syndrome, hence reported. Read More

    Ferrokinetics is associated with the left ventricular mass index in patients with chronic kidney disease.
    Acta Cardiol 2017 Jul 14:1-7. Epub 2017 Jul 14.
    a Kidney Disease Center, Japanese Red Cross Nagoya Daini Hospital , Nagoya , Japan.
    Background Patients with chronic kidney disease (CKD) often have the complication of anaemia. Usage of an erythropoietin-stimulating agent accelerates iron deficiency because it promotes iron utilization. Recently, iron administration was reported to be effective for patients with cardiac failure. Read More

    RBP4/Lp-PLA2/Netrin-1 signaling regulation of cognitive dysfunction in diabetic nephropathy complicated with silent cerebral infarction.
    Exp Clin Endocrinol Diabetes 2017 Jul 13. Epub 2017 Jul 13.
    Departments of Pathophysiology, Basic Medical College, Chongqing Medical University, Chongqing, China.
    Aim To investigate the RBP4/Lp-PLA2/Netrin-1 signal regulation of cognitive function impairment in diabetic nephropathy patients with silent cerebral infarction (SCI). Methods One-hundred patients newly diagnosed with diabetic nephropathy patients were included. The patients were divided into SCI group and NSCI group according to the radiological data. Read More

    Metabolomics study of cadmium-induced diabetic nephropathy and protective effect of caffeic acid phenethyl ester using UPLC-Q-TOF-MS combined with pattern recognition.
    Environ Toxicol Pharmacol 2017 Jun 28;54:80-92. Epub 2017 Jun 28.
    School of Chemistry and Chemical Engineering, Xi'an University of Science and Technology, Xi'an, 710054, China. Electronic address:
    Diabetic nephropathy (DN) is the most severe complication of diabetes and multiple factors are involved in the pathogenesis of DN. Among them, cadmium (Cd) acts as a risk factor inducing the occurrence of DN. The present study focused on investigating the protective role of caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, against Cd-induced DN in mice based on ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS)and pattern recognition. Read More

    Association between the vitamin D receptor gene polymorphisms and diabetic nephropathy risk: a meta-analysis.
    Nephrology (Carlton) 2017 Jul 13. Epub 2017 Jul 13.
    Department of Nephrology, Weifang People's Hospital, Weifang, 261041, China.
    Aims: Diabetic nephropathy (DN) is a severe microvascular complication frequently associated with type 1 and type 2 diabetes mellitus. The objective of this study was to estimate the effect between Apa I, Bsm I, Fok I and Taq I polymorphisms of the vitamin D receptor (VDR) gene and DN susceptibility.

    Methods: Eligible case-control studies published updated to March 2017 were searched. Read More

    Renal Oxygenation in the Pathophysiology of Chronic Kidney Disease.
    Front Physiol 2017 28;8:385. Epub 2017 Jun 28.
    Division of Nephrology-Hypertension, University of California San Diego School of Medicine, VA San Diego Healthcare SystemSan Diego, CA, United States.
    Chronic kidney disease (CKD) is a significant health problem associated with high morbidity and mortality. Despite significant research into various pathways involved in the pathophysiology of CKD, the therapeutic options are limited in diabetes and hypertension induced CKD to blood pressure control, hyperglycemia management (in diabetic nephropathy) and reduction of proteinuria, mainly with renin-angiotensin blockade therapy. Recently, renal oxygenation in pathophysiology of CKD progression has received a lot of interest. Read More

    Mesangial Cell Mammalian Target of Rapamycin Complex 1 Activation Results in Mesangial Expansion.
    J Am Soc Nephrol 2017 Jul 12. Epub 2017 Jul 12.
    Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan; and.
    Human glomerular diseases can be caused by several different diseases, many of which include mesangial expansion and/or proliferation followed by glomerulosclerosis. However, molecular mechanisms underlying the pathologic mesangial changes remain poorly understood. Here, we investigated the role of the mammalian target of rapamycin complex 1 (mTORC1)-S6 kinase pathway in mesangial expansion and/or proliferation by ablating an upstream negative regulator, tuberous sclerosis complex 1 (TSC1), using tamoxifen-induced Foxd1-Cre mice [Foxd1ER(+) TSC1 mice]. Read More

    Reciprocal Expression of miR-214 and PTEN by high Glucose Regulates Glomerular Mesangial and Proximal Tubular Epithelial Cell Hypertrophy and Matrix Expansion.
    Am J Physiol Cell Physiol 2017 Jul 12:ajpcell.00081.2017. Epub 2017 Jul 12.
    University of Texas Health Sciences Center San Antonio
    Aberrant expression of microRNAs (miRs) contributes to diabetic renal complications including renal hypertrophy and matrix protein accumulation. Reduced expression of PTEN by hyperglycemia contributes to these processes. We considered involvement of microRNA in the downregulation of PTEN. Read More

    Inhibition of high glucose-induced inflammation and fibrosis by a novel curcumin derivative prevents renal and heart injury in diabetic mice.
    Toxicol Lett 2017 Jul 9. Epub 2017 Jul 9.
    Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
    Hyperglycemia-induced inflammation and fibrosis have important roles in the pathogenesis of diabetic nephropathy and cardiomyopathy. With inflammatory cytokines and signaling pathways as important mediators, targeting inflammation may be an effective approach to new avenue for treating diabetic complications. J17, a molecule with structural similarities to curcumin, exhibited good anti-inflammatory activities by inhibiting LPS-induced inflammatory response in macrophages. Read More

    Plasma bradykinin and early diabetic nephropathy lesions in type 1 diabetes mellitus.
    PLoS One 2017 10;12(7):e0180964. Epub 2017 Jul 10.
    University of Louisville, Louisville, Kentucky, United States of America.
    Objective: To examine the association of bradykinin and related peptides with the development of diabetic nephropathy lesions in 243 participants with type 1 diabetes (T1D) from the Renin-Angiotensin System Study who, at baseline, were normoalbuminuric, normotensive and had normal or increased glomerular filtration rate (GFR).

    Design: Plasma concentrations of bradykinin and related peptides were measured at baseline by quantitative mass spectrometry. All participants were randomly assigned at baseline to receive placebo, enalapril or losartan during the 5 years between kidney biopsies. Read More

    Change in serum Nampt levels and its significances in diabetic nephropathy patients.
    Endocr Metab Immune Disord Drug Targets 2017 Jul 11. Epub 2017 Jul 11.
    The Endocrine Department of the First Hospital of China Medical University, Shenyang, Liaoning Province . China.
    Background: Nicotinamide phosphoribosyltransferase(Nampt) has a variety of biological effects, which can participate in the development of inflammatory diseases, metabolism diseases and chronic kidney disease, et al. However, he role of Nampt in T2DM and DN are still controversial.

    Objective: To investigate changes in serum Nampt levels and its significance in diabetic nephropathy (DN). Read More

    Study of Visfatin Level in Type 1 Diabetic Children and Adolescents.
    Open Access Maced J Med Sci 2017 Jun 11;5(3):299-304. Epub 2017 Jun 11.
    Pediatrics Department, National Research Centre, Cairo, Egypt.
    Background: Visfatin is an intracellular enzyme, known as nicotinamide phosphoribosyltransferase (Nampt) and pre-B-cell colony-enhancing factor (PBEF-1). It has insulin-mimetic effects and lowers plasma glucose levels.

    Aim: The aim of the work was to assess serum concentration of Visfatin in type 1 diabetic children and adolescents and study its relationships with duration of diabetes, body mass index (BMI), glycemic control, insulin dosage, lipid profile and microvascular complications. Read More

    Farnesoid X Receptor Agonism Protects against Diabetic Tubulopathy: Potential Add-On Therapy for Diabetic Nephropathy.
    J Am Soc Nephrol 2017 Jul 10. Epub 2017 Jul 10.
    Institute of Clinical Chemistry and Pathobiochemistry and
    Established therapies for diabetic nephropathy (dNP) delay but do not prevent its progression. The shortage of established therapies may reflect the inability to target the tubular compartment. The chemical chaperone tauroursodeoxycholic acid (TUDCA) ameliorates maladaptive endoplasmic reticulum (ER) stress signaling and experimental dNP. Read More

    Can Fundus Fluorescein Angiography be Performed for Diabetic Patients on Oral Metformin?(△).
    Chin Med Sci J 2017 Jun;32(2):119-122
    Department of Ophthalmology, The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shanxi 710077, China.
    Metformin is a kind of biguanide hypoglycemic agent that has been widely used in patients with diabetes mellitus. In clinical practice, whether metformin should be stopped before Fundus fluorescein angiography (FFA) remains largely unclear. Some endocrinologists suggest stop metformin before FFA. Read More

    Carbamylation is a competitor of glycation for protein modification in vivo.
    Diabetes Metab 2017 Jul 6. Epub 2017 Jul 6.
    University of Reims Champagne-Ardenne, laboratory of biochemistry and molecular biology, CNRS/URCA UMR no. 7369 MEDyC, faculté de médecine, 51, rue Cognacq-Jay, 51095 Reims, France; University hospital of Reims, laboratory of paediatric biology and research, 51095 Reims, France. Electronic address:
    Aim: Chronic kidney disease (CKD) and diabetes mellitus are two diseases that accelerate protein molecular ageing through carbamylation and glycation reactions, characterized by the binding of urea-derived isocyanic acid and of sugars on proteins, respectively. These two reactions target the same protein amino groups and, thus, compete with each other. Such competition may arise especially in diabetic patients with nephropathy. Read More

    Diminazene aceturate prevents type 1 diabetic nephropathy through increasing glomerular ACE2 and AT2 receptor expression.
    Br J Pharmacol 2017 Jul 8. Epub 2017 Jul 8.
    Laboratory of Molecular Pharmacology, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Rajasthan, 333031, India.
    Background And Purpose: Angiotensin converting enzyme 2 (ACE2) shows its protective actions through degrading Ang II. ACE2 activity and its expression was found to be reduced in glomeruli of diabetic patients as well as in animal models of diabetes. Several recent studies have also showed the potential role of recombinant ACE2 administration in preventing diabetic nephropathy (DN). Read More

    Association of single-nucleotide polymorphisms in the RAGE gene and its gene-environment interactions with diabetic nephropathy in Chinese patients with type 2 diabetes.
    Oncotarget 2017 Jun 28. Epub 2017 Jun 28.
    Institute of Anal-Colorectal Surgery, No. 150th Central Hospital of PLA, Luoyang, 471000, P. R. China.
    Aims: To investigate the association of several single nucleotide polymorphisms (SNPs) within RAGE gene and additional gene- smoking interaction with diabetic nephropathy (DN) risk in Chinese patients with type 2 diabetes mellitus (T2DM).

    Methods: A total of 865 participants (570 males, 295 females) were selected, including 430 T2DM complicated DN patients and 435 controls (T2DM patients without DN). Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and smoking. Read More

    Comparison between Atorvastatin and Rosuvastatin in Renal Function Decline among Patients with Diabetes.
    Endocrinol Metab (Seoul) 2017 Jun;32(2):274-280
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
    Background: Although the beneficial effects of statin treatment in dyslipidemia and atherosclerosis have been well studied, there is limited information regarding the renal effects of statins in diabetic nephropathy. We aimed to investigate whether, and which, statins affected renal function in Asian patients with diabetes.

    Methods: We enrolled 484 patients with diabetes who received statin treatment for more than 12 months. Read More

    End-Stage Kidney Failure in Oman: An Analysis of Registry Data with an Emphasis on Congenital and Inherited Renal Diseases.
    Int J Nephrol 2017 8;2017:6403985. Epub 2017 Jun 8.
    Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK.
    Globally, end-stage kidney disease (ESKD) is a huge burden on health care systems. The aims of this study were to perform a comprehensive epidemiological and etiological report of ESKD patients commencing RRT in Oman with an emphasis on genetic causes and inherited kidney disease. All newly registered Omani patients with ESKD commencing RRT from 2001 until 2015 (n = 2,922) were analysed using the RRT register in Oman. Read More

    [Diabetic nephropathy and cardiovascular risk].
    G Ital Nefrol 2017 Mar;34(Suppl 69):104-118
    Aldo Moro University of Bari, Azienda Ospedaliero-Universitaria Consorziale Policlinico, Bari, Italy.
    The curious case of the Diabetic Nephropathy (DN) : paraphrasing the name of a famous movie is certainly an unusual way to deal with a medical-scientific issue, but it could be extremely functional. Benjamin Button, with his backward life, breaks the unquestionable certainty of human life progressing through fixed steps. Similarly, the knowledge of DN seems go backwards; therefore, although it is a pathology which clinicians are usually sure, maybe too sure, they know every aspect of, the clinical nephrologist managing a diabetic patient often finds himself/herself far from his/her old certainties and proper answers. Read More

    Long-lasting response to oral therapy in a young male with monogenic diabetes as part of HNF1B-related disease.
    Endocrinol Diabetes Metab Case Rep 2017 23;2017. Epub 2017 Jun 23.
    Endocrinologists in Complejo Hospitalario Universitario de Albacete, Castilla La ManchaSpain.
    Mutations in hepatocyte nuclear factor 1β gene (HNF1B) are responsible for a multisystemic syndrome where monogenic diabetes (classically known as MODY 5) and renal anomalies, mostly cysts, are the most characteristic findings. Urogenital malformations, altered liver function tests, hypomagnesemia or hyperuricemia and gout are also part of the syndrome. Diabetes in these patients usually requires early insulinization. Read More

    Klotho levels: association with insulin resistance and albumin-to-creatinine ratio in type 2 diabetic patients.
    Int Urol Nephrol 2017 Jul 4. Epub 2017 Jul 4.
    Department of Nephrology, Centro Hospitalar do Algarve, Faro, Portugal.
    Purpose: The present study aimed at evaluating the relationship between Klotho levels and insulin resistance and albumin-to-creatinine ratio (ACR) in type 2 diabetic patients with CKD.

    Methods: We conducted an observational, cross-sectional study in our outpatient diabetic nephropathy clinic from 2014 to 2016, enrolling a total of 107 type 2 diabetic patients with stage 2-3 CKD, with a mean age of 59 years. Several clinical and laboratorial parameters were evaluated, including those related to mineral and carbohydrate metabolism. Read More

    Diabetic rats present higher urinary loss of proteins and lower renal expression of megalin, cubilin, ClC-5, and CFTR.
    Physiol Rep 2017 Jul;5(13)
    Laboratório Integrado de Ciências Morfofuncionais, Núcleo em Ecologia e Desenvolvimento Socioambiental de Macaé, Universidade Federal do Rio de Janeiro, Macaé, Rio de Janeiro, Brazil
    Diabetic nephropathy (DN) occurs in around 40% of those with diabetes. Proteinuria is the main characteristic of DN and develops as a result of increased permeability of the glomerulus capillary wall and/or decreased proximal tubule endocytosis. The goal of this work was to evaluate renal function and the expression of megalin, cubilin, CFTR (cystic fibrosis transmembrane conductance regulator), and ClC-5 in the proximal tubule and renal cortex of rats with type 1 diabetes. Read More

    Potent long-acting rhFGF21 analog for treatment of diabetic nephropathy in db/db and DIO mice.
    BMC Biotechnol 2017 Jul 4;17(1):58. Epub 2017 Jul 4.
    School of Pharmacy, Wenzhou Medical University, Wenzhou, 325035, China.
    Background: Fibroblast growth factor 21 (FGF21) is an endocrine-acting hormone that has the potential to treat diabetic nephropathy. However, development of FGF21 into a therapeutic has been hindered due to its low intrinsic bio-stability. In our previous study, we have developed a recombinant human FGF21 (rhFGF21) variant by site-directed mutagenesis and solid-phase PEGylation, which retained its biological function. Read More

    Metformin ameliorates diabetic nephropathy in a rat model of low-dose streptozotocin-induced diabetes.
    Exp Ther Med 2017 Jul 18;14(1):383-390. Epub 2017 May 18.
    Department of Pharmacology, School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, P.R. China.
    The present study aimed to explore the renoprotective effect of metformin on diabetic nephropathy in type 2 diabetic rats. A rat model of type 2 diabetic nephropathy (T2DN) was successfully induced via a high-fat diet combined with a single low-dose of streptozotocin. Metformin was administered intragastrically for 13 weeks, and fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), HDL-c, LDL-c, urinary and serum creatinine levels were subsequently examined at the end of administration. Read More

    Rutin suppresses high glucose-induced ACTA2 and p38 protein expression in diabetic nephropathy.
    Exp Ther Med 2017 Jul 23;14(1):181-186. Epub 2017 May 23.
    Department of Clinical Pharmacy, Jilin University School of Pharmaceutical Sciences, Changchun, Jilin 130021, P.R. China.
    The present study investigated the effect of rutin on high glucose-induced actin, α2, smooth muscle, aorta (ACTA2) and p38 protein expression in diabetic nephropathy (DN). Human mesangial cells were divided into a control group, high glucose-induced mesangial cell group, high glucose + captopril group, and high glucose + rutin group (low, middle and high doses of rutin). Cell viability, adenosine 5'-triphosphate (ATP) content, cell cycle, and ACTA2 and p38 protein expression were examined using MTT assay, ATP assay kit, flow cytometry and immunofluorescence staining in cultured human mesangial cells, respectively. Read More

    KATP channels in high glucose-induced rat mesangial cell proliferation and release of MMP-2 and fibronectin.
    Exp Ther Med 2017 Jul 17;14(1):135-140. Epub 2017 May 17.
    Department of Endocrinology, Shanghai Changzheng Hospital, Shanghai 200003, P.R. China.
    ATP-sensitive potassium (KATP) channels are well characterized in cardiac, pancreatic and many other muscle cells. The purpose of this study was to determine if KATP channels play a role in diabetic nephropathy (DN). In the present study, functional expression of the KATP channel was examined in rat mesangial cells with or without high glucose (HG) stimulation. Read More

    Lipotoxicity-Induced PRMT1 Exacerbates Mesangial Cell Apoptosis via Endoplasmic Reticulum Stress.
    Int J Mol Sci 2017 Jul 3;18(7). Epub 2017 Jul 3.
    Life Science Institutes, University of Michigan, Ann Arbor, MI 48109, USA.
    Lipotoxicity-induced mesangial cell apoptosis is implicated in the exacerbation of diabetic nephropathy (DN). Protein arginine methyltransferases (PRMTs) have been known to regulate a variety of biological functions. Recently, it was reported that PRMT1 expression is increased in proximal tubule cells under diabetic conditions. Read More

    Evaluation of neutrophil gelatinase-associated lipocalin and cystatin C as early markers of diabetic nephropathy.
    Ann Afr Med 2017 Jul-Sep;16(3):101-106
    Department of Medicine, Era's Lucknow Medical College, Lucknow, Uttar Pradesh, India.
    Introduction: Diabetes mellitus (DM) is a major cause of concern because of its increasing prevalence rate and related microvascular as well as macrovascular complications, including kidney disease. Microalbuminuria has been accepted as the earliest marker for diabetic nephropathy; however, a large proportion of renal impairment occurs in nonalbuminuric state. We planned to investigate the serum and urinary levels of the tubular damage markers (neutrophil gelatinase-associated lipocalin [NGAL] and cystatin C [Cys C]) in patients of type 2 diabetes to detect early kidney injury. Read More

    [Periprosthetic joint infection caused by Rhodococcus equi. Case report].
    Orv Hetil 2017 Jul;158(27):1071-1074
    Ortopédiai Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Üllői út 78/B II. emelet, 1082.
    Rhodococcus equi is a rare pathogen in humans causing infections mostly in immunocompromised hosts. We present the first case of periprosthetic joint infection caused by Rhodococcus equi. An 88-year-old male patient was referred to our clinic with a history of fever and right hip pain. Read More

    Serum levels of WNT1-inducible signaling pathway protein-1 (WISP-1): a noninvasive biomarker of renal fibrosis in subjects with chronic kidney disease.
    Am J Transl Res 2017 15;9(6):2920-2932. Epub 2017 Jun 15.
    Department of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of ChinaChengdu, China.
    WNT1-inducible signaling pathway protein-1 (WISP-1) is an extracellular matrix-related protein that plays multiple roles in cellular physiology and pathology. Accumulating evidence shows that WISP-1 is involved in the process underlying fibrotic diseases. However, the correlation between WISP-1 and renal fibrosis is unknown. Read More

    Increased Circulating and Urinary Levels of Soluble TAM Receptors in Diabetic Nephropathy.
    Am J Pathol 2017 Jun 29. Epub 2017 Jun 29.
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:
    TAM receptors (Tyro3, Axl, and Mer) have been implicated in regulation of innate immunity. Circulating levels of TAM receptor soluble forms (sTyro3, sAxl, sMer) are related to autoimmune disorders. We investigated levels of TAM and their ligand protein S in patients with diabetes. Read More

    Dietary intake habits and prevalence of nocturia in Japanese patients with type 2 diabetes mellitus.
    J Diabetes Investig 2017 Jul 1. Epub 2017 Jul 1.
    Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.
    Aims/introduction: No reports have been published on the association between dietary intake habits and nocturia in the diabetes population. We therefore estimate this issue among Japanese patients with diabetes mellitus.

    Materials And Methods: Study subjects in the present study were 785 Japanese patients with type 2 diabetes mellitus. Read More

    Diabetic nephropathy: serum miR-9 confers a poor prognosis in and is associated with level changes of vascular endothelial growth factor and pigment epithelium-derived factor.
    Biotechnol Lett 2017 Jun 30. Epub 2017 Jun 30.
    Department of Endocrinology, First Center Hospital of Baoding City, 320 North Greatwall Street, Baoding, 071000, China.
    Objective: To investigate the relationship between the serum level of miR-9 and the progression of diabetic nephropathy (DN) and related molecular mechanisms.

    Results: Thirty-five healthy subjects and 140 DN patients were divided into five groups: control, DN I-II, DN III, DN IV and DN V. Serum level of miR-9 was measured by real-time qPCR. Read More

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