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    Clinical usefulness of videocapillaroscopy and selected endothelial cell activation markers in people with Type 1 diabetes mellitus complicated by microangiopathy.
    Adv Med Sci 2017 May 22;62(2):368-373. Epub 2017 May 22.
    Department of Rehabilitation, Medical University of Bialystok, Poland. Electronic address:
    Purpose: Microvascular abnormalities are one of the most important causes of persistent diabetic complications. The aim of our study was to compare microvascular changes examined by nailfold videocapillaroscopy (NVC) examination with serum concentrations of vascular endothelial growth factor (VEGF), soluble thrombomodulin (sTM) and endothelin-1 (ET-1) in people with Type 1 diabetes with and without microangiopathy.

    Material/methods: The study included 106 people with Type 1 diabetes and 40 healthy controls. Read More

    Modulation of heme oxygenase-1 expression and activity affects streptozotocin-induced diabetic nephropathy in rats.
    Fundam Clin Pharmacol 2017 May 23. Epub 2017 May 23.
    Pharmacology Department, Faculty of Medicine, Minia University, Egypt.
    Heme oxygenase (HO)-1 has exhibited nephro-protective actions in different animal models; however, its full mechanistic potential in diabetic nephropathy (DN) has not yet been elucidated. Hence, the present study has been undertaken by inducing DN in rats using streptozotocin (50mg/kg i.p. Read More

    Comparative pharmacokinetics of acteoside from Total glycoside Extracted from Leaves of Rehmannia and Dihuangye total glycoside capsule in normal and diabetic nephropathy rats.
    Biomed Chromatogr 2017 May 23. Epub 2017 May 23.
    Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, and Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
    Rehmannia glutinosa Libosch (RG), is officially listed in the Chinese Pharmacopoeia and is widely used in China. In this paper, a sensitive and rapid ultra-performance liquid chromatography-mass spectrometry (UPLC-TQ-MS) including multiple-reaction monitoring mode was developed and applied to study the pharmacokinetics effect of acteoside from Total glycoside Extracted from Leaves of Rehmannia (TLR) and Dihuangye total glycoside capsule (DTG) in normal and diabetic nephropathy rats. Diabetic nephropathy rats model was induced by intraperitoneal injection of a small dose of streptozotocin and high-fat diet and plus 5% glucose drinking water. Read More

    Diabetic nephropathy: Time to withhold development and progression - A review.
    J Adv Res 2017 Jul 21;8(4):363-373. Epub 2017 Apr 21.
    Rheumatology and Rehabilitation Department, School of Medicine, Cairo University, Egypt.
    The recent discoveries in the fields of pathogenesis and management of diabetic nephropathy have revolutionized the knowledge about this disease. Little was added to the management of diabetic nephropathy after the introduction of renin angiotensin system blockers. The ineffective role of the renin- angiotensin system blockers in primary prevention of diabetic nephropathy in type 1 diabetes mellitus necessitated the search for other early therapeutic interventions that target alternative pathogenic mechanisms. Read More

    MiRNA-29c regulates the expression of inflammatory cytokines in diabetic nephropathy by targeting tristetraprolin.
    Sci Rep 2017 May 24;7(1):2314. Epub 2017 May 24.
    Nephrology Hospital, The First Affiliated Hospital of Zhengzhou University, NO. 1 Jianshe Eastern Road, 6th Floor of NO. 7 Building, Erqi District, Zhengzhou, 450052, China.
    Diabetic nephropathy is one of the most prevalent chronic complications of Diabetes mellitus, but its pathogenesis remains elusive. This study was designed to determine the role of tristetraprolin (TTP), inflammatory cytokines and microRNAs (miRNAs) in DN. The blood and urine samples were obtained from 32 patients with DN, 33 patients with type 2 DM, and 35 normal healthy subjects as controls. Read More

    In silico identification of potential drug compound against Peroxisome proliferator activated receptor-gamma by virtual screening and toxicity studies for treatment of Diabetic Nephropathy.
    J Biomol Struct Dyn 2017 May 24:1-64. Epub 2017 May 24.
    b Department of Botany , Gargi College (University of Delhi) , New Delhi , 110049 , India.
    Diabetic Nephropathy is a serious complication of Diabetes Mellitus. Current therapeutic strategies of Diabetic Nephropathy are based on control of modifiable risks like hypertension, glucose levels, and dyslipidemia. Peroxisome proliferator activated receptor-gamma (PPAR-γ) is implicated in several metabolic syndromes including Diabetic Nephropathy, besides obesity, insulin insensitivity, dislipidemia, inflammation and hypertension. Read More

    Caffeic Acid Attenuates Diabetic Kidney Disease via Modulation of Autophagy in a High-Fat Diet/Streptozotocin- Induced Diabetic Rat.
    Sci Rep 2017 May 23;7(1):2263. Epub 2017 May 23.
    Anatomy & Embryology Department, Faculty of Science, Ain Shams University, P.O. box 11381, Abbassia, Cairo, Egypt.
    The aim of this study is to evaluate the anti-diabetic nephropathy effect of Caffeic acid and to prove our hypothesis for its mechanism of action that it may occur by reactivation of autophagy pathway via suppression of autophagy regulatory miRNAs. In vivo, high-fat diet and streptozotocin-induced (HFD-STZ) diabetic rats were treated with Caffeic acid once per day for 12 weeks before and after development of diabetic nephropathy. Blood and urine biochemical parameters, autophagy transcripts and their epigenetic regulators together with renal tissue morphology were investigated. Read More

    Sodium glucose cotransporter 2 in mesangial cells and retinal pericytes and its implications for diabetic nephropathy and retinopathy.
    Glycobiology 2017 May 23. Epub 2017 May 23.
    Midori no Clinic (Midori Internal Medicine Clinic), Fukuoka, Japan.
    Retinopathy and nephropathy are life-threatening diabetic complications that decrease patient quality of life. Although the mechanisms underlying these conditions have been extensively studied, they remain unknown. Recent reports have demonstrated the presence of SGLT2 in retinal pericytes and mesangial cells. Read More

    Trimetazidine in the prevention of contrast-induced nephropathy in chronic kidney disease.
    Cardiovasc Revasc Med 2017 Feb 10. Epub 2017 Feb 10.
    Cardiology Department, Ain Shams University, Cairo, Egypt.
    Background: Contrast induced nephropathy (CIN) may be defined as Acute Renal Failure (ARF) that occurs within 24-72h of exposure to intra-venous or intra-arterial iodinated contrast media that cannot be attributed to other causes. CIN occurs in up to 5% of hospitalized patients with normal renal function prior to injection of contrast media. It occurs more frequently in patients with renal impairment particularly if associated with diabetic nephropathy. Read More

    Development and validation of the angiotensin-converting enzyme inhibitor (ACEI) induced angioedema investigator rating scale and proposed discharge criteria.
    BMC Health Serv Res 2017 May 22;17(1):366. Epub 2017 May 22.
    Clinical Research, Department of Internal Medicine, Division of Immunology/Allergy Section, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
    Background: The use of angiotensin-converting enzyme inhibitors (ACEI) has been associated with the development of bradykinin-mediated angioedema. With ever-widening indications for ACEI in diseases including hypertension, congestive heart failure and diabetic nephropathy, a concomitant increase in ACEI-Angioedema (ACEI-A) has been reported. At present there is no validated severity scoring or discharge criteria for ACEI-A. Read More

    Jiangtang decoction ameliorate diabetic nephropathy through the regulation of PI3K/Akt-mediated NF-κB pathways in KK-Ay mice.
    Chin Med 2017 19;12:13. Epub 2017 May 19.
    Integrated Laboratory of Traditional Chinese Medicine and Western Medicine, Peking University First Hospital, Beijing, People's Republic of China.
    Background: Jiangtang decoction (JTD) is a China patented drug which contains Euphorbia humifusa Willd, Salvia miltiorrhiza Bunge, Astragalus mongholicus Bunge, Anemarrhena asphodeloides Bunge, and Coptis chinensis Franch. For decades, it has also been used clinically to treat diabetic nephropathy (DN) effectively; however, the associated mechanisms remain unknown. Thus, the present study aimed to examine the protective efficacy of JTD in DN and elucidate the underlying molecular mechanisms. Read More

    Association between the risk of falls and osteoporotic fractures in patients with type 2 diabetes mellitus.
    Endocr J 2017 May 19. Epub 2017 May 19.
    Internal Medicine 1, Shimane University Faculty of Medicine, Izumo 693-8501, Japan.
    Diabetes mellitus is associated with an increased risk of falls, which increases the incidence of osteoporotic fractures and accordingly decreases quality of life. However, the association between fall risk and diabetic complications is not completely understood. Therefore, the aim of this study was to examine the association between fall risk and osteoporotic fractures in patients with type 2 diabetes mellitus (T2DM). Read More

    Cardiovascular disease biomarkers are associated with declining renal function in type 2 diabetes.
    Diabetologia 2017 May 20. Epub 2017 May 20.
    Centre for Population Health Sciences, University of Edinburgh, Old Medical School, Teviot Place, Edinburgh, EH8 9AG, UK.
    Aims/hypothesis: We investigated whether biochemical cardiovascular risk factors and/or markers of subclinical cardiovascular disease were associated with the development of reduced renal function in people with type 2 diabetes.

    Methods: A cohort of 1066 Scottish men and women aged 60-74 years with type 2 diabetes from the Edinburgh Type 2 Diabetes Study were followed up for a median of 6.7 years. Read More

    Microvascular Complications Associated With Rapid Improvements in Glycemic Control in Diabetes.
    Curr Diab Rep 2017 Jul;17(7):48
    , 1101 Beacon St. 8W, Brookline, MA, 02446, USA.
    Purpose Of Review: Aggressive glycemic control has become the standard clinical approach to diabetes care. Unintended consequences have included the development of microvascular complications that are related to the rapidity of glycemic improvement.

    Recent Findings: Diabetic neuropathy may develop in up to 10% of individuals secondary to aggressive glycemic control. Read More

    SGLT2 Inhibitors as a Therapeutic Option for Diabetic Nephropathy.
    Int J Mol Sci 2017 May 18;18(5). Epub 2017 May 18.
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan.
    Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD) worldwide. Glycemic and blood pressure (BP) control are important but not sufficient to attenuate the incidence and progression of DN. Sodium-glucose cotransporter (SGLT) 2 inhibitors are a new class of glucose-lowering agent suggested to exert renoprotective effects in glucose lowering-dependent and independent fashions. Read More

    Impact of estimated glomerular filtration rate on diabetic macular edema.
    Int Ophthalmol 2017 May 18. Epub 2017 May 18.
    Retina and Uvea Services, Dr R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, 110029, India.
    Purpose: Diabetic macular edema (DME) is a major cause of visual impairment in patients with diabetes and is influenced by various systemic factors. This study evaluates the effect of renal status on DME using estimated glomerular filtration rate (eGFR) as a study marker.

    Methods: This was a prospective observational cross-sectional study. Read More

    Serum bilirubin levels are negatively associated with diabetic retinopathy in patients with type 1 diabetes and normal renal function.
    Int Ophthalmol 2017 May 18. Epub 2017 May 18.
    Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, University Hospital Merkur, Dugi dol 4a, Zagreb, Croatia.
    Introduction: Previous studies suggested that total serum bilirubin levels are negatively associated with diabetic retinopathy (DR) and nephropathy in patients with diabetes mellitus. The objective of this study was to explore the relationship between serum total bilirubin levels and prevalence of DR in patients with type 1 diabetes (T1DM) and normal renal function.

    Methods: Study included 163 T1DM with normal renal function (urinary albumin excretion rate <30 mg/24 h, estimated glomerular filtration rate (eGFR) >60 ml min(-1)1. Read More

    Diabetic Kidney Disease: Challenges, Progress, and Possibilities.
    Clin J Am Soc Nephrol 2017 May 18. Epub 2017 May 18.
    Providence Health Care, Spokane, Washington.
    Diabetic kidney disease develops in approximately 40% of patients who are diabetic and is the leading cause of CKD worldwide. Although ESRD may be the most recognizable consequence of diabetic kidney disease, the majority of patients actually die from cardiovascular diseases and infections before needing kidney replacement therapy. The natural history of diabetic kidney disease includes glomerular hyperfiltration, progressive albuminuria, declining GFR, and ultimately, ESRD. Read More

    Renoprotective effect of a novel selective PPARα modulator K-877 in db/db mice: A role of diacylglycerol-protein kinase C-NAD(P)H oxidase pathway.
    Metabolism 2017 Jun 3;71:33-45. Epub 2017 Mar 3.
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka, Japan. Electronic address:
    Objective: Several clinical studies have shown the beneficial effects of peroxisome proliferator-activated receptor α (PPARα) agonists on diabetic nephropathy. However, the molecular mechanism is not fully understood. Here we show that K-877, a novel selective PPARα modulator, ameliorates nephropathy in db/db mice via inhibition of renal lipid content and oxidative stress. Read More

    Effects of nurse telesupport on transition between specialized and primary care in diabetic patients: study protocol for a randomized controlled trial.
    Trials 2017 May 18;18(1):222. Epub 2017 May 18.
    Post Graduate Program in Medical Sciences - Division of Endocrinology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
    Background: According to the Global Diabetes Plan, a unified health system with preventive and educational strategies is essential to proper diabetes care and primary settings should be the main site of care. In Brazil, there is limited access to outpatient hospital diabetes services, while primary-care diabetes support is underutilized. Telemedicine can be a useful adjunct to support discharge of stable patients with type 2 diabetes to the primary care setting. Read More

    Emerging Roles for MicroRNAs in Diabetic Microvascular Disease: Novel Targets for Therapy.
    Endocr Rev 2017 Apr;2017(1):1-22
    Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, and.
    Chronic, low-grade systemic inflammation and impaired microvascular function are critical hallmarks in the development of insulin resistance. Accordingly, insulin resistance is a major risk factor for type 2 diabetes and cardiovascular disease. Accumulating studies demonstrate that restoration of impaired function of the diabetic macro- and microvasculature may ameliorate a range of cardiovascular disease states and diabetes-associated complications. Read More

    Endothelin A receptor antagonists in diabetic kidney disease.
    Curr Opin Nephrol Hypertens 2017 May 17. Epub 2017 May 17.
    aDivision of Nephrology and Hypertension, 1st Department of Medicine, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, GreecebDepartment of Medicine, Indiana University School of Medicine and Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, Indiana, USA.
    Purpose Of Review: Despite optimal therapy of diabetic nephropathy with agents blocking the renin-angiotensin-aldosterone system, the residual risk of nephropathy progression to end-stage renal disease (ESRD) remains high. The purpose of this review is to discuss the potential role of endothelin antagonism as a therapeutic tool to reduce residual proteinuria and delay kidney injury progression among patients with diabetic nephropathy.

    Recent Findings: Preclinical studies have shown that endothelin receptor antagonists (ERAs) exert proteinuria lowering and nephroprotective actions in experimental models of diabetic nephropathy. Read More

    Association between serum 25-hydroxyvitamin D and glycated hemoglobin levels in type 2 diabetes patients with chronic kidney disease.
    J Diabetes Investig 2017 May 18. Epub 2017 May 18.
    Division of Nephrology, Department of Medicine, University of Malaya, 59100, Kuala Lumpur, Malaysia.
    Aims/introduction: Vitamin D is suggested to influence glucose homeostasis. An inverse relationship between serum 25-hydroxyvitamin D [25(OH)D] and glycemic control in non-chronic kidney disease (CKD) patients with type 2 diabetes (T2D) was reported. We aimed to examine this association among T2D patients with CKD. Read More

    Harefuah 2016 Jul;155(7):439-442
    Diabetic Nephropathy Lab.
    Introduction: The antioxidant protein haptoglobin (Hp) plays a major role in the development of diabetic complications such as diabetic nephropathy and retinopathy. In humans, two alleles of Hp were identified: 1 and 2 with three possible genotypes: 1-1, 2-1, and 2-2. The Hp protein products differ in their biochemical and biophysical properties, such as their antioxidant capacity. Read More

    Growth arrest-specific protein 6 (Gas6) as a noninvasive biomarker for early detection of diabetic nephropathy.
    Clin Exp Hypertens 2017 May 17:1-6. Epub 2017 May 17.
    a Department of Gerontology, South Campus, Renji Hospital School of Medicine , Shanghai Jiaotong University , Shanghai , China.
    Background: To investigate the diagnostic level of cystatin C and growth arrest-specific gene 6 (Gas6) levels in elderly type 2 diabetic patients with different degrees of diabetic nephropathy (DN).

    Methods: Four hundred and eighty-two old people, including 130 healthy controls, 130 normoalbuminuric diabetic patients, 122 with microalbuminuria, and 100 with macroalbuminuria, were recruited. Plasma Gas6 and serum cystatin C levels were measured. Read More

    Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy.
    J Diabetes Res 2017 23;2017:3797802. Epub 2017 Apr 23.
    Department of Nephrology, The Second Hospital of Jilin University, Changchun, Jilin 130041, China.
    Diabetic nephropathy (DN) is manifested as increased urinary protein level, decreased glomerular filtration rate, and final renal dysfunction. DN is the leading cause of end-stage renal disease worldwide and causes a huge societal healthcare burden. Since satisfied treatments are still limited, exploring new strategies for the treatment of this disease is urgently needed. Read More

    Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic Nephropathy.
    J Diabetes Res 2017 23;2017:3560238. Epub 2017 Apr 23.
    Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
    Diabetic nephropathy (DN), a leading cause of end-stage renal disease (ESRD), becomes a worldwide problem. Ultrastructural changes of the glomerular filtration barrier, especially the pathological changes of podocytes, lead to proteinuria in patients with diabetes. Podocytes are major components of glomerular filtration barrier, lining outside of the glomerular basement membrane (GBM) to maintain the permeability of the GBM. Read More

    Partial remission by cyclosporine monotherapy in a patient with membranous nephropathy superimposed diabetic nephropathy.
    CEN Case Rep 2016 Nov 16;5(2):219-222. Epub 2016 Jul 16.
    Department of General Internal Medicine 1, Kawasaki Medical School, Kawasaki Hospital, 2-1-80 Nakasange, Kita-ku, Okayama, 700-8505, Japan.
    It has been noted that cyclosporine A (CsA) is an effective drug for membranous nephropathy (MN). Diabetes is a common disease that sometimes causes nephrotic syndrome. We report the case of an 89-year-old woman with type 2 diabetes mellitus who exhibited nephrotic syndrome. Read More

    Follow Up of Value of the Intrarenal Resistivity Indices and Different Renal Biomarkers for Early Identification of Diabetic Nephropathy in Type 1 Diabetic Patients.
    Open Access Maced J Med Sci 2017 Apr 20;5(2):188-192. Epub 2017 Mar 20.
    Clinical Pathology Department, National Research Centre, Cairo, Egypt.
    Aim: To evaluate intrarenal resistivity index (RI) and different biomarkers of diabetic nephropathy (DN) with clinical signs of DN and its progression over time as early detection of DN.

    Patients And Methods: This longitudinal study included 48 type 1 diabetic patients who were studied at baseline and after three years. A blood sample was taken for assessment of glycosylated haemoglobin (HbA1), lipid profile and a urine sample was taken for assessment of albumin/creatinine ratio, Neutrophil gelatinase-associated lipocalin (NGAL), liver-type fatty acid binding protein (L-FABP) and kidney injury molecule-1 (Kim-1) at baseline and after three years. Read More

    Characterization and comparison of SGLT2 inhibitors: Part 3. Effects on diabetic complications in type 2 diabetic mice.
    Eur J Pharmacol 2017 May 12. Epub 2017 May 12.
    Drug Discovery Research, Astellas Pharma Inc., Ibaraki, Japan.
    In this study, we investigated and compared the effects of all six sodium-glucose cotransporter (SGLT) 2 inhibitors commercially available in Japan on diabetes-related diseases and complications in type 2 diabetic mice. Following 4-week repeated administration to diabetic mice, all SGLT2 inhibitors showed significant improvement in diabetes-related diseases and complications, including obesity; abnormal lipid metabolism; steatohepatitis; inflammation; endothelial dysfunction; and nephropathy. While all SGLT2 inhibitors exerted comparable effects in reducing hyperglycemia, improvement of these diabetes-related diseases and complications was more potent with the two long-acting drugs (ipragliflozin and dapagliflozin) than with the four intermediate-acting four drugs (tofogliflozin, canagliflozin, empagliflozin, and luseogliflozin), albeit without statistical significance. Read More

    Urinary lysophopholipids are increased in diabetic patients with nephropathy.
    J Diabetes Complications 2017 May 10. Epub 2017 May 10.
    Institut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease, Toulouse, France; Université Toulouse III Paul-Sabatier, Toulouse, France. Electronic address:
    Diabetic nephropathy (DN) is a major cause of chronic kidney disease that frequently leads to end stage renal failure. Lysophosphatidic acid (LPA) and lysophosphatidylcholine (LPC) are lysophospholipid mediators shown to accumulate in kidney and to promote renal inflammation and tubulo-interstitial fibrosis in diabetic rodent models. Here we assessed whether LPA and LPC were associated to the development of nephropathy in diabetic human patients. Read More

    FoxO1 Promotes Mitophagy in the Podocytes of Diabetic Male Mice via the PINK1/Parkin Pathway.
    Endocrinology 2017 May 12. Epub 2017 May 12.
    Department of Endocrinology and Metabolism, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
    We recently showed that Forkhead-box class O1 (FoxO1) activation protects against high glucose-induced injury by preventing mitochondrial dysfunction in the rat kidney cortex. In addition, FoxO1 has been reported to mediate PINK1 transcription and promote autophagy in response to mitochondrial oxidative stress in murine cardiomyocytes. In this study, we ascertained whether over-expressing FoxO1 in the kidney cortex reverses pre-established diabetic nephropathy in animal models. Read More

    Attenuation of diabetic nephropathy by Sanziguben Granule inhibiting EMT through Nrf2-mediated anti-oxidative effects in streptozotocin (STZ)-induced diabetic rats.
    J Ethnopharmacol 2017 May 10. Epub 2017 May 10.
    School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China. Electronic address:
    Ethnopharmacological Relevance: Diabetic nephropathy (DN) is an acute and serious diabetic complication characterized by renal hypertrophy and renal fibrosis with the expansion of extracellular matrices. Diabetic nephropathy has become a major cause of end-stage kidney disease. Sanziguben Granule (SZGB) is a compound prescription which has been widely applied in clinical medicine for the prevention and treatment of diabetic nephropathy as well as for acute and chronic kidney injuries. Read More

    ACE2 as therapy for glomerular disease: the devil is in the detail.
    Kidney Int 2017 Jun;91(6):1269-1271
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan.
    Angiotensin-converting enzyme 2 cleaves angiotensin (Ang) II to Ang(1-7), which antagonizes the deleterious effects of Ang II. In this issue, 2 groups administered angiotensin-converting enzyme 2 in murine models of kidney disease. Angiotensin-converting enzyme 2 did not improve glomerular injury in 2 models of mild diabetic nephropathy but was partially protective in an Alport syndrome model. Read More

    Type 1 diabetes mellitus care and education in China: The 3C study of coverage, cost, and care in Beijing and Shantou.
    Diabetes Res Clin Pract 2017 Feb 28;129:32-42. Epub 2017 Feb 28.
    Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, National Clinical Research Center for Metabolic Diseases, No. 139, Renmin Middle Road, Furong District, Changsha 410011, Hunan Province, China.
    Aims: The paucity of data on Type 1 diabetes in China hinders progress in care and policy-making. This study compares Type 1 diabetes care and clinical outcomes in Beijing and Shantou with current clinical guidelines.

    Methods: The 3C Study was a cross-sectional study of the clinical practices and outcomes of people with Type 1 diabetes. Read More

    Association between dipstick hematuria and decline in estimated glomerular filtration rate among Japanese patients with type 2 diabetes: A prospective cohort study [Diabetes Distress and Care Registry at Tenri (DDCRT 14)].
    J Diabetes Complications 2017 Apr 18. Epub 2017 Apr 18.
    Department of Diabetology, Nara Medical University, Kashihara, Nara 634-8521, Japan.
    Aims: To assess the association between dipstick hematuria and estimated glomerular filtration rate (eGFR) decline in Japanese patients with type 2 diabetes.

    Methods: Longitudinal data were obtained from 3068 Japanese patients with type 2 diabetes. To assess the independent association between dipstick hematuria and eGFR decline, we used Cox proportional hazard model adjusted for potential confounders. Read More

    T-cadherin gene variants are associated with nephropathy in subjects with type 1 diabetes.
    Nephrol Dial Transplant 2017 May 12. Epub 2017 May 12.
    INSERM, UMR-S 1138, Centre de Recherches des Cordeliers, Paris, France.
    Background.: High plasma adiponectin levels are associated with diabetic nephropathy (DN). T-cadherin gene ( CDH13 ) variants have been shown to be associated with adiponectin levels. Read More

    Brazilin Ameliorates Diabetic Nephropathy and Inflammation in db/db Mice.
    Inflammation 2017 May 11. Epub 2017 May 11.
    Department of Nephrology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Xueyuanxi Road, No. 109, Wenzhou, Zhejiang, 325000, China.
    Hyperglycemia and inflammation play important roles in the pathogenesis of diabetic nephropathy (DN). Brazilin might be an effective pharmacological agent against hyperglycemia and inflammation. In our present study, we explored whether brazilin mitigated pathological progression, inflammation, and extracellular matrix (ECM) accumulation in a mouse model of diabetic nephropathy. Read More

    Impact of FGF23 level on calcium and phosphorus levels in post-renal transplantation.
    J Renal Inj Prev 2017 3;6(2):99-102. Epub 2016 Sep 3.
    Kidney Transplantation Complications Research Center, Department of Internal Medicine, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Ira.
    Introduction: The level of fibroblast growth factor 23 (FGF23) may be considered as a prognostic factor for assessing renal function in regulating components of phosphate and vitamin D hemostasis. Objectives: The present study aimed to evaluate the prognostic value of FGF23 level to predict renal function after renal transplantation. Patients and Methods: Fifteen consecutive patients scheduled for renal transplantation. Read More

    ADAMTS13 Retards Progression of Diabetic Nephropathy by Inhibiting Intrarenal Thrombosis in Mice.
    Arterioscler Thromb Vasc Biol 2017 May 11. Epub 2017 May 11.
    From the Department of Internal Medicine and Stead Family Department of Pediatrics, University of Iowa; and National Cardiovascular Centre Research Institute, Suita, Osaka, Japan.
    Objective: ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type I repeats-13) prevents microvascular thrombosis by cleaving prothrombogenic ultralarge von Willebrand factor (VWF) multimers. Clinical studies have found association between reduced ADAMTS13-specific activity, ultralarge VWF multimers, and thrombotic angiopathy in patients with diabetic nephropathy. It remains unknown, however, whether ADAMTS13 deficiency or ultralarge VWF multimers have a causative effect in diabetic nephropathy. Read More

    Clinical characteristics and mortality in patients treated in a Multidisciplinary Diabetic Foot Unit.
    Endocrinol Diabetes Nutr 2017 May 26;64(5):241-249. Epub 2017 Apr 26.
    Unidad de Pie Diabético, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, España; Departamento de Endocrinología y Nutrición, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, España; Departamento de Medicina y Especialidades Médicas, Universidad de Alcalá, Alcalá de Henares, España.
    Background And Objective: This study reviews the clinical characteristics of patients with diabetic foot ulcer treated in a Multidisciplinary Diabetic Foot Unit (MDFU) and analyzes the mortality and factors associated with its survival.

    Material And Methods: Data from all patients who attended the MDFU for the first time for a diabetic foot ulcer during the 2008-2014 period were analized. The patients were followed until their death or until June 30, 2016, for up to 8 years. Read More

    Association of circulatory asymmetric dimethylarginine (ADMA) with diabetic nephropathy in Asian Indians and its causative role in renal cell injury.
    Clin Biochem 2017 May 8. Epub 2017 May 8.
    Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialties Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention, Gopalapuram, Chennai 600086, India. Electronic address:
    Aim: Asymmetric dimethylarginine (ADMA) is involved in the regulation of nitric oxide synthesis and in the maintenance of vascular tone and structure. But the role and status of ADMA in diabetes induced kidney injury is not clear. Hence this study is investigating the role of ADMA in the progression of kidney injury and its circulatory status in Asian Indians with and without diabetic nephropathy. Read More

    Aldosterone signaling regulates the over-expression of claudin-4 and -8 at the distal nephron from type 1 diabetic rats.
    PLoS One 2017 11;12(5):e0177362. Epub 2017 May 11.
    Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), Mexico City, México.
    Hyperglycemia in diabetes alters tight junction (TJ) proteins in the kidney. We evaluated the participation of aldosterone (ALD), and the effect of spironolactone (SPL), a mineralocorticoid receptor antagonist, on the expressions of claudin-2, -4, -5 and -8, and occludin in glomeruli, proximal and distal tubules isolated from diabetic rats. Type 1 diabetes was induced in female Wistar rats by a single tail vein injection of streptozotocin (STZ), and SPL was administrated daily by gavage, from days 3-21. Read More

    Prevalence of primary aldosteronism among patients with type 2 diabetes.
    Clin Endocrinol (Oxf) 2017 May 10. Epub 2017 May 10.
    Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
    Context: Diabetes and hypertension coexist in 40-60% of individuals with type 2 diabetes. The coexistence of this two conditions is associated with increased risk of retinopathy, nephropathy and cardiovascular disease.

    Objective: To investigate the prevalence of primary aldosteronism (PA) in a general cohort of persons with type 2 diabetes. Read More

    Changes in the NFκB and E-cadherin expression are associated to diabetic nephropathy inPsammomys obesus.
    Saudi J Biol Sci 2017 May 18;24(4):843-850. Epub 2016 May 18.
    Laboratoire de Biologie et de Physiologie des Organismes/MMDED, Faculté des Sciences Biologiques, USTHB, El-Alia, Dar El Beida, Algeria.
    Diabetes mellitus is a major leading cause of end-stage renal failure, characterized by kidney inflammation and glomerular dysfunction, in worldwide. Kidney inflammation is associated to modifications in the expression levels of pro-inflammatory molecules, such as nuclear factor-κB (NFκB) and adhesion molecules, such as E-cadherin, leading to glomerular dysfunction. However, the relationships between these two processes in human diabetic nephropathy remain an open question. Read More

    Podocyte specific knockout (KO) of cyclooxygenase 2 (COX2) exacerbates diabetic kidney disease.
    Am J Physiol Renal Physiol 2017 May 10:ajprenal.00614.2016. Epub 2017 May 10.
    Duke University Medical Center
    Enhanced expression of cyclooxygenase 2 (COX2) in podocytes contributes to glomerular injury in diabetic kidney disease, but some basal level of podocyte COX2 expression might be required to promote podocyte attachment and/or survival. To investigate the role of podocyte COX2 expression in diabetic kidney disease, we deleted COX2 specifically in podocytes in a mouse model of type 1 diabetes mellitus (Akita mice). Podocyte specific knockout (KO) of COX2 did not affect renal morphology or albuminuria in non-diabetic mice. Read More

    Angiotensinogen (AGT) gene missense polymorphisms (rs699 and rs4762) and diabetic nephropathy in Caucasians with type 2 diabetes mellitus.
    Bosn J Basic Med Sci 2017 May 10. Epub 2017 May 10.
    Department of Internal Medicine, General Hospital Slovenj Gradec, Slovenj Gradec, Slovenia.
    Gene polymorphisms associated with the renin-angiotensin-aldosterone system (RAAS) have been extensively studied in diabetic nephropathy (DN) patients, due to therapeutic potential of targeting the RAAS and slowing down the disease progression. The aim of our study was to examine the association between angiotensinogen (AGT) gene polymorphisms (rs699 and rs4762) and DN in Caucasians with type 2 diabetes mellitus (T2DM). A total of 651 unrelated Slovenian (Caucasian) T2DM patients were tested for AGT rs699 and rs4762 polymorphisms using a novel fluorescence-based competitive allele-specific polymerase chain reaction (KASPar) assay. Read More

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