33,080 results match your criteria Diabetic Nephropathy


SGLT2 inhibition to address the unmet needs in diabetic nephropathy.

Diabetes Metab Res Rev 2019 Apr 18:e3171. Epub 2019 Apr 18.

Department of Medical Sciences, University of Turin, Turin, Italy.

Current treatment of diabetic nephropathy is effective; however, substantial gaps in care still remain and new therapies are urgently needed to reduce the global burden of the complication. Desirable properties of an "ideal" new drug should include: primary prevention of microalbuminuria, additive/synergistic anti-proteinuric effect in combination therapy with renin angiotensin system blockers, reduction of chronic kidney disease progression to lower the risk of end-stage renal disease, and cardiovascular protection. Growing evidence suggests that sodium-glucose cotransporter 2 inhibitors (SGLT2i) may fulfill many of these criteria and represent novel tools to cover the unmet needs in diabetic nephropathy care. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/dmrr.3171
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http://dx.doi.org/10.1002/dmrr.3171DOI Listing
April 2019
1 Read

A new strategy for vascular complications in young people with type 1 diabetes mellitus.

Nat Rev Endocrinol 2019 Apr 17. Epub 2019 Apr 17.

Department of Paediatrics, University of Cambridge, Cambridge, UK.

Diabetes vascular complications, including cardiovascular disease, diabetic nephropathy and retinopathy, have a negative effect on the long-term prognosis of young people with type 1 diabetes mellitus (T1DM). Poor glycaemic control and consequent increased HbA levels are major risk factors for the development of vascular complications. HbA levels are the main focus of current management strategies; however, the recommended target is rarely achieved in adolescents. Read More

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http://dx.doi.org/10.1038/s41574-019-0198-2DOI Listing

Hypoglycemia in People with Type 2 Diabetes and CKD.

Clin J Am Soc Nephrol 2019 Apr 17. Epub 2019 Apr 17.

Kidney Research Institute.

Background And Objectives: Among people with diabetes mellitus, CKD may promote hypoglycemia through altered clearance of glucose-lowering medications, decreased kidney gluconeogenesis, and blunted counter-regulatory response. We conducted a prospective observational study of hypoglycemia among 105 individuals with type 2 diabetes treated with insulin or a sulfonylurea using continuous glucose monitors.

Design, Setting, Participants & Measurements: We enrolled 81 participants with CKD, defined as eGFR<60 ml/min per 1. Read More

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http://dx.doi.org/10.2215/CJN.11650918DOI Listing

Survival Advantage of African American Dialysis Patients with End-Stage Renal Disease Causes Related to APOL1.

Cardiorenal Med 2019 Apr 17;9(4):212-221. Epub 2019 Apr 17.

Kidney Disease Branch, NIDDK, Bethesda, Maryland, USA,

Background: Observational studies show that African American (AA) dialysis patients have longer survival than European Americans. We hypothesized that apolipoprotein L1 (APOL1) genetic variation, associated with nephropathy in AAs, contributes to the survival advantage in AA dialysis patients.

Methods: We examined the association between race and mortality among 37,097 adult dialysis patients, including 54% AAs and 46% European Americans from a large dialysis organization (entry period from July 2001 to June 2006, follow-up through June 2007), within each cause of end-stage renal disease (ESRD) category associated with APOL1 renal risk variants using Cox proportional hazard models. Read More

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https://www.karger.com/Article/FullText/496472
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http://dx.doi.org/10.1159/000496472DOI Listing
April 2019
4 Reads

Salidroside ameliorates Adriamycin nephropathy in mice by inhibiting β-catenin activity.

J Cell Mol Med 2019 Apr 16. Epub 2019 Apr 16.

Key Laboratory for Neuroregeneration of Jiangsu Province and Ministry of Education, Nantong University, Nantong, China.

Salidroside is a major phenylethanoid glycoside in Rhodiola rosea L., a traditional Chinese medicine, with multiple biological activities. It has been shown that salidroside possesses protective effects for alleviating diabetic renal dysfunction, contrast-induced-nephropathy and other kidney diseases. Read More

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http://dx.doi.org/10.1111/jcmm.14340DOI Listing

The Role of Uric Acid in Acute Kidney Injury.

Nephron 2019 Apr 16:1-9. Epub 2019 Apr 16.

Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA.

Studies have demonstrated the presence of a strong association between serum uric acid (SUA) and acute kidney injury (AKI) consistently across several disease models. Exposure to SUA at different time periods and concentrations has reliably resulted in AKI whether assessed by conventional or novel biomarkers or by kinetic estimated glomerular filtration rate (KeGFR) engineered for non-steady dynamic states. In experimental models, moderate hyperuricemia was associated with an absence of intrarenal crystals, manifestation of tubular injury, macrophage infiltration, and increased expression of inflammatory mediators that were attenuated with uric acid lowering therapy with rasburicase, a recombinant urate oxidase. Read More

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http://dx.doi.org/10.1159/000499939DOI Listing

[Efficacy and safety of Breviscapine Injection in treatment of diabetic nephropathy: systematic review and Meta-analysis of randomized controlled trials].

Zhongguo Zhong Yao Za Zhi 2019 Feb;44(4):833-844

Institute of Basic Research Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700,China.

This study aimed to systematically evaluate the efficacy and safety of Breviscapine Injection in the treatment of diabetic nephropathy( DN). Eight electronic databases and Clinical Trials.gov were searched to collect randomized controlled trials on Breviscapine Injection in the treatment of DN. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181128.007DOI Listing
February 2019

Changes in Soluble Tumour Necrosis Factor Receptor type 1 levels and early renal function decline in patients with diabetes.

J Diabetes Investig 2019 Apr 15. Epub 2019 Apr 15.

Endocrine Centre, Austin Health.

The relationship between serial changes in soluble tumour necrosis factor receptor type 1 (TNFR1) levels and an early decline in estimated glomerular filtration rate (eGFR) decline remains to be defined. We found that in patients with an early decline in renal function (n=30), soluble TNFR1 values increased (2595±683 vs 3596±1203 pg/mL, p<0.001) as eGFR decreased (89±1 vs 51±2 mL/min/1. Read More

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http://dx.doi.org/10.1111/jdi.13061DOI Listing

miRNA-214 suppresses oxidative stress in diabetic nephropathy via the ROS/Akt/mTOR signaling pathway and uncoupling protein 2.

Exp Ther Med 2019 May 7;17(5):3530-3538. Epub 2019 Mar 7.

Department of Endocrinology, Wuxi Second People's Hospital, Wuxi, Jiangsu 214000, P.R. China.

In the present study, the function of microRNA (miR)-214 on diabetic nephropathy (DN) and diabetes of proximal tubular cells was investigated. Reverse transcription-quantitative polymerase chain reaction was used measure the expression of miR-214 in rats with DN and ELISA was performed to measure oxidative stress and ROS levels. Results indicated that miR-214 expression in the peripheral blood was significantly decreased in rats with DN. Read More

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http://dx.doi.org/10.3892/etm.2019.7359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447795PMC

Exercise training upregulates SIRT1 to attenuate inflammation and metabolic dysfunction in kidney and liver of diabetic mice.

Nutr Metab (Lond) 2019 2;16:22. Epub 2019 Apr 2.

Department of Physical Education, National Taiwan Normal University, 162, Section 1, Heping E. Rd, Taipei City, Taiwan.

Background: Chronic inflammation and metabolic dysregulation may eventually cause tissue damage in obesity-related diseases such as type 2 diabetes. The effects of SIRT1 on integration of metabolism and inflammation may provide a therapeutic target for treatment of obesity-related diseases. We examined the underlying mechanism of moderate intensity aerobic exercise on kidney and liver in obese diabetic mice, mainly focusing on inflammation and metabolic dysfunction. Read More

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http://dx.doi.org/10.1186/s12986-019-0349-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446356PMC

Key Genes and Signaling Pathways Contribute to the Pathogensis of Diabetic Nephropathy.

Iran J Kidney Dis 2019 Mar;13(2):87-97

Department of Nephrology, China-Japan Union Hospital of Jilin University, No.126 Xiantai Street, Changchun, China.

Introduction: Diabetic nephropathy (DN) is a serious complication of diabetes mellitus involving damage to the capillaries in the glomerulus. This study aimed to explore key genes and signaling pathways participate in the progression of DN.

Methods: Two gene expression profile datasets GSE1009 and GSE30528 downloaded from Gene Expression Omnibus (GEO) were used to analyze the differentially expressed genes (DEGs) between DN samples and controls. Read More

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March 2019
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Association of the polymorphisms in FOXO1 gene and diabetic nephropathy risk.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1471-1475

a Department of Endocrinology , The Third Hospital of Hebei Medical University , Shijiazhuang , China.

Purpose: This study was aimed to study the hypothesis that forkhead box O1 (FOXO1) gene rs17446614 and rs17592236 single nucleotide polymorphisms (SNPs) influenced the development of diabetic nephropathy (DN).

Methods: This study included 138 DN patients and 149 healthy controls. Controls were matched with the patients in age and gender. Read More

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http://dx.doi.org/10.1080/21691401.2019.1601103DOI Listing
December 2019
3 Reads

MicroRNAs in the Progress of Diabetic Nephropathy: A Systematic Review and Meta-Analysis.

Evid Based Complement Alternat Med 2019 7;2019:3513179. Epub 2019 Mar 7.

Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun, China.

Background: We conducted a systematic review and meta-analysis of existing literature to evaluate the different outcomes of microRNAs (miRNAs) in diabetic nephropathy (DN), including urinary albumin excretion rates, urinary albumin creatinine rates, glomerular filtration rate, HbAc1, and creatinine.

Methods: Electronic databases including PUBMED, MEDLINE, and EMBASE were searched for eligible publications to July 2018. The following comparisons between treatment groups were included: normal group versus DN group; control group versus micro/macroalbuminuria group. Read More

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https://www.hindawi.com/journals/ecam/2019/3513179/
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http://dx.doi.org/10.1155/2019/3513179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431481PMC
March 2019
1 Read

Evaluation of various risk factors associated with multidrug-resistant organisms isolated from diabetic foot ulcer patients.

J Lab Physicians 2019 Jan-Mar;11(1):58-62

Department of Surgery, Government Medical College and Hospital, Chandigarh, India.

Aims: Diabetic foot ulcer is a dreaded complication of diabetes. Diabetic foot ulcer patients are often infected with multidrug resistant organism (MDRO) due to chronic course of the wound, inappropriate antibiotics treatment, frequent hospital admission, neuropathy, nephropathy, and peripheral vascular disease.

Materials And Methods: This prospective study was conducted in our 750 bedded hospital for a period of 6 months. Read More

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http://www.jlponline.org/text.asp?2019/11/1/58/254072
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http://dx.doi.org/10.4103/JLP.JLP_106_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437817PMC
April 2019
1 Read

Urinary N-acetyl-beta-d-glucosaminidase levels in diabetic adults.

J Lab Physicians 2019 Jan-Mar;11(1):1-4

Department of Physiology, University of Benin, Benin City, Nigeria.

Diabetes mellitus (DM) is known to be one of the most common causes of end-stage renal disease. The disease is usually not detected on time, because of the large functioning reserve of the kidney. Currently used markers (serum creatinine, creatinine clearance, urea, and electrolytes) remain relatively normal even when more than 50% of the renal nephron is not functioning. Read More

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http://www.jlponline.org/text.asp?2019/11/1/1/254086
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http://dx.doi.org/10.4103/JLP.JLP_164_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437819PMC
April 2019
1 Read

High-Resistant Starch, Low-Protein Flour Intervention on Patients With Early Type 2 Diabetic Nephropathy: A Randomized Trial.

J Ren Nutr 2019 Apr 11. Epub 2019 Apr 11.

Department of Nutrition, Shandong Provincial Hospital, Jinan, China; Department of Nutrition and Food Hygiene, School of Public health, Shandong University, Jinan, China. Electronic address:

Objective: The objective of this study is to explore the effect of high-resistant starch (RS), low-protein flour as a source of RS on patients with early type 2 diabetic nephropathy (DN) through the clinical intervention trial.

Design: This was a single center, randomized, comparative, open-label trial. Seventy-five patients with early DN, aged 18 to 80 y, were recruited and randomly assigned to two groups. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10512276183028
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http://dx.doi.org/10.1053/j.jrn.2018.12.005DOI Listing
April 2019
4 Reads

Interleukin-17A blockade reduces albuminuria and kidney injury in an accelerated model of diabetic nephropathy.

Kidney Int 2019 Mar 8. Epub 2019 Mar 8.

Cellular and Molecular Biology in Renal and Vascular Pathology Laboratory, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

Diabetic nephropathy (DN) is one of the most common complications of diabetes, and currently the first end-stage renal disease worldwide. New strategies to treat DN using agents that target inflammatory pathways have attracted special interest. Recent pieces of evidences suggest a promising effect of IL-17A, the Th17 effector cytokine. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.031DOI Listing

Protective effect of a polysaccharide from Dipsacus asper Wall on streptozotocin (STZ)-induced diabetic nephropathy in rat.

Int J Biol Macromol 2019 Apr 11. Epub 2019 Apr 11.

Hospital of Nephrology of the First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, PR China.

The effects of a polysaccharide (DAP) from the roots of Dipsacus asper on renal complication in streptozotocin (STZ)-induced diabetic rats were investigated in the present study. Administration of DAP (100 and 300 mg/kg) for 4 weeks significantly decreased the fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) levels, but increase the body weight of STZ-induced diabetic rats. Increased kidney weight index, serum creatinine (Scr), blood urea nitrogen (BUN), urine protein, and urinary albumin excretion (UAE) levels along with decreased creatinine clearance (Ccr) were nearly reversed to the normal levels by DAP. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.069DOI Listing

Cycloastragenol can negate constitutive STAT3 activation and promote paclitaxel-induced apoptosis in human gastric cancer cells.

Phytomedicine 2019 Mar 31;59:152907. Epub 2019 Mar 31.

Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea. Electronic address:

Background: Cycloastragenol (CAG), a triterpene aglycone is commonly prescribed for treating hypertension, cardiovascular disease, diabetic nephropathy, viral hepatitis, and various inflammatory-linked diseases.

Hypothesis: We investigated CAG for its action on signal transducer and activator of transcription 3 (STAT3) activation cascades, and its potential to sensitize gastric cancer cells to paclitaxel-induced apoptosis.

Methods: The effect of CAG on STAT3 phosphorylation and other hallmarks of cancer was deciphered using diverse assays in both SNU-1 and SNU-16 cells. Read More

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http://dx.doi.org/10.1016/j.phymed.2019.152907DOI Listing

Loss of Inverse Association between Framingham Risk Score and Estimated Glomerular Filtration Rate in Moderate to Severe Diabetic Kidney Disease.

Arch Iran Med 2019 Feb 1;22(2):91-98. Epub 2019 Feb 1.

Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: We investigated the association of estimated glomerular filtration rate (eGFR) with Framingham risk score (FRS), and actual cardiovascular disease (CVD) in patients with type 2 diabetes (T2DM). We also assessed improvement in FRS for prediction of CVD after inclusion of eGFR and albuminuria.

Methods: A total of 571 patients with T2DM and mean age 55 were divided into 2 groups based on the presence of CVD. Read More

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February 2019

[Diabetic kidney disease (Update 2019) : Position paper of the Austrian Diabetes Association and the Austrian Society for Nephrology].

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Klinische Abteilung für Nephrologie, Universitätsklinik für Innere Medizin, Medizinische Universität Graz, Graz, Österreich.

Recent epidemiological investigations have shown that approximately 2-3% of all Austrians suffer from diabetes with renal involvement, i. e. 250,000 people in Austria are affected. Read More

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http://link.springer.com/10.1007/s00508-018-1425-x
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http://dx.doi.org/10.1007/s00508-018-1425-xDOI Listing
April 2019
3 Reads

Antioxidant and nephroprotection activities of : A phytochemical, in-vitro and ex-vivo studies.

Heliyon 2019 Mar 28;5(3):e01365. Epub 2019 Mar 28.

Faculty of Sciences, University of Lomé, Togo.

Management of chronic renal failure is exceedingly expensive. Despite of encouraging experimental outcomes, there is a lack of potent nephroprotective drugable molecules in a clinics or market. To develop a nephroprotective phytomedicine, the present study was designed to do a literature survey on reported phytochemical and biological analysis of and to carry out chemoprofiling, in-vitro antioxidant and ex-vivo nephroprotective capacity of the title plant. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24058440183688
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http://dx.doi.org/10.1016/j.heliyon.2019.e01365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441829PMC
March 2019
2 Reads

Structural basis for ligand modulation of the CCR2 conformational landscape.

Proc Natl Acad Sci U S A 2019 Apr 11. Epub 2019 Apr 11.

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093

CC chemokine receptor 2 (CCR2) is a part of the chemokine receptor family, an important class of therapeutic targets. These class A G-protein coupled receptors (GPCRs) are involved in mammalian signaling pathways and control cell migration toward endogenous CC chemokine ligands, named for the adjacent cysteine motif on their N terminus. Chemokine receptors and their associated ligands are involved in a wide range of diseases and thus have become important drug targets. Read More

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http://dx.doi.org/10.1073/pnas.1814131116DOI Listing
April 2019
10 Reads

Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in the Pathophysiology and Experimental Therapy of Type-2 Diabetes.

Front Immunol 2019 27;10:571. Epub 2019 Mar 27.

Department of Translational Medicine and Therapeutics, Bart's and The London School of Medicine and Dentistry, The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.

Annexin A1 (ANXA1) is an endogenously produced anti-inflammatory protein, which plays an important role in the pathophysiology of diseases associated with chronic inflammation. We demonstrate that patients with type-2 diabetes have increased plasma levels of ANXA1 when compared to normoglycemic subjects. Plasma ANXA1 positively correlated with fatty liver index and elevated plasma cholesterol in patients with type-2 diabetes, suggesting a link between aberrant lipid handling, and ANXA1. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446914PMC
March 2019
1 Read

Infection in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis.

Gut Liver 2019 Feb 27. Epub 2019 Feb 27.

Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.

Background/aims: Insufficient systematic reviews were conducted in the previous metaanalyses about the prevalence of infection in patients with chronic kidney disease (CKD). The aim of this study was to evaluate the prevalence of infection in patients with CKD.

Methods: A systematic review of studies that evaluated the prevalence of infection in patients with CKD compared to a control group was performed. Read More

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http://dx.doi.org/10.5009/gnl18517DOI Listing
February 2019
1 Read

Angiotensin blockade attenuates diabetic nephropathy in hypogonadal adult male rats.

Can J Physiol Pharmacol 2019 Apr 10. Epub 2019 Apr 10.

Faculty of Medicine- Suez Canal University, Pharmacology , Pharmacology department- Faculty of Medicine- Suez Canal University , Ismailia, Egypt , +2-064 ;

This study examined the effect of the aromatase inhibitor letrozole (0.5 mg/kg) alone or in combination with the angiotensin-receptor blocker valsartan (30 mg/kg) against streptozocin-induced diabetic nephropathy (DN) in hypogonadal (HG) rats for 12 weeks. First, we tested the HG effect on hormone levels, inflammatory cytokines, and oxidative stress in non-diabetic (ND) and diabetic (D) rats. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0572DOI Listing
April 2019
1 Read

Type 2 diabetes and the kidney: insights from cardiovascular outcome trials.

Diabetes Obes Metab 2019 Apr 10. Epub 2019 Apr 10.

Diabetes Division, Department of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", Naples, Italy.

Diabetic kidney disease (DKD) still remains a progressive condition that is associated with higher risk of end-stage kidney disease and significant cardiovascular morbidity and mortality. Twelve cardiovascular outcome trials (CVOTs) in type 2 diabetes (T2D) have been so far published. Most trials with dipeptidyl-peptidase inhibitors (SAVOR-TIMI 53 with saxagliptin, EXAMINE with alogliptin, TECOS with sitagliptin, and CARMELINA with linagliptin), and with the glucagon-like peptide-1 receptor agonists (GLP-1 RAs) (ELIXA with lixisenatide, LEADER with liraglutide, SUSTAIN-6 with semaglutide, EXCSEL with exenatide once weekly, and HARMONY with albiglutide) pointed toward reduced albuminuria which is a surrogate endpoint possibly heralding renal function preservation. Read More

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http://dx.doi.org/10.1111/dom.13743DOI Listing
April 2019
1 Read

Brazilian chronic dialysis survey 2017.

J Bras Nefrol 2019 Mar 28. Epub 2019 Mar 28.

Sociedade Brasileira de Nefrologia, São Paulo, SP, Brasil.

Introduction: Having national data on chronic dialysis is essential in treatment planning.

Objective: To present data of the survey from the Brazilian Society of Nephrology on patients with chronic kidney disease on dialysis in July 2017.

Methods: Data was collected from dialysis units in Brazil. Read More

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http://dx.doi.org/10.1590/2175-8239-JBN-2018-0178DOI Listing
March 2019
1 Read

Clinical and histological features and therapeutic strategies for IgA nephropathy.

Clin Exp Nephrol 2019 Apr 9. Epub 2019 Apr 9.

Department of Nephrology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Chronic glomerulonephritis is the second most common reason, after diabetic nephropathy, for initiation of dialysis in Japan and IgA nephropathy (IgAN) is the most prevalent form of chronic glomerulonephritis. In the half century since IgAN was initially reported, our understanding of the long-term prognosis, clinical and histological features, pathogenesis of onset and progression, risk factors for progression, and appropriate treatment under different clinical and histological conditions, has steadily increased. Strong experimental and clinical evidence, the Clinical Practice Guidelines for IgA Nephropathy in Japan, the Oxford Classification, and the Kidney Disease Improving Global Outcomes guidelines have all contributed to the appropriate treatment of IgAN. Read More

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http://dx.doi.org/10.1007/s10157-019-01735-4DOI Listing
April 2019
2 Reads

[The double exclusion of the pathologist and Nazi victim Paul Kimmelstiel (1900-1970). German version].

Pathologe 2019 Apr 9. Epub 2019 Apr 9.

University Medical School MTI II, RWTH Aachen, Wendlingweg 2, 52074, Aachen, Deutschland.

The Hamburg pathologist Paul Kimmelstiel (1900-1970) gave his name to diabetic glomerulosclerosis (Kimmelstiel-Wilson syndrome) and thus conquered a place in the history of medicine. Far less known, however, is the fact that Kimmelstiel was one of the Jewish victims of the Third Reich. He was dismissed in 1933, saw himself forced to emigrate in 1934, and fought for "rehabilitation" ("Wiedergutmachung") after 1945. Read More

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http://dx.doi.org/10.1007/s00292-019-0584-5DOI Listing
April 2019
1 Read

CXCL6 Promotes Renal Interstitial Fibrosis in Diabetic Nephropathy by Activating JAK/STAT3 Signaling Pathway.

Front Pharmacol 2019 25;10:224. Epub 2019 Mar 25.

Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

In this study the role of CXCL6 in diabetic nephropathy (DN) was investigated. It was found to be overexpression in DN patients and DN rat model. And the expression of fibrosis-related cytokines was consistent with the expression of CXCL6. Read More

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http://dx.doi.org/10.3389/fphar.2019.00224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442023PMC
March 2019
2 Reads

FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX.

Oxid Med Cell Longev 2019 6;2019:3286928. Epub 2019 Mar 6.

Department of Endocrinology and Metabolism, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052 Henan Province, China.

Objective: The generation of hyperglycemia-induced reactive oxygen species (ROS) is a key event in diabetic nephropathy (DN) development. Since forkhead box class O1 (FOXO1) is associated with oxidative stress and shows a positive effect on DN, its role on renal function and the underlying mechanism is still unclear.

Methods: We examined the role of FOXO1 (in a transgenic diabetic mouse model overexpressing ) and (in human HK-2 cells with knockin (KI) and knockout (KO) cultured under high glucose). Read More

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https://www.hindawi.com/journals/omcl/2019/3286928/
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http://dx.doi.org/10.1155/2019/3286928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431359PMC
March 2019
2 Reads

Apelin and chemerin as promising adipokines in children with type 1 diabetes mellitus.

Diabetes Metab Syndr Obes 2019 22;12:383-389. Epub 2019 Mar 22.

Endocrine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Background: Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in children that may be due to micro or macrovascular complications. Diabetic renal disease or nephropathy is a common complication of DM, clinically silent and the only detectable abnormality due to the presence of microalbuminuria.

Subjects And Methods: This study was a case-control study. Read More

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https://www.dovepress.com/apelin-and-chemerin-as-promising-a
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http://dx.doi.org/10.2147/DMSO.S189264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434915PMC
March 2019
2 Reads

Diagnostic role of renal biopsy in PLAR1-antibody-positive patients with nephrotic syndrome.

Mod Pathol 2019 Apr 8. Epub 2019 Apr 8.

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Renal biopsy is the gold standard for diagnosis of membranous nephropathy. Circulating PLAR1 antibody found in 75% of patients with membranous nephropathy is very specific for the diagnosis of this disease. Therefore, the question arises whether PLAR1-antibody-positive patients still need a diagnostic renal biopsy. Read More

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http://dx.doi.org/10.1038/s41379-019-0267-zDOI Listing
April 2019
1 Read

Pharmacological Management of Diabetic Nephropathy.

Curr Vasc Pharmacol 2019 Apr 5. Epub 2019 Apr 5.

1st Cardiology Department, Kapodestrian University, Athens. Greece.

Introduction: Diabetes mellitus (DM) is one of the most common diseases worldwide. Its adverse effects on several body organs has made DM a priority to improve its treatment. One of the most serious complications of DM is diabetic nephropathy (DN). Read More

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http://dx.doi.org/10.2174/1570161117666190405164749DOI Listing
April 2019
1 Read

Blockage of myeloid differentiation 2 attenuates diabetic nephropathy via reducing local RAS activation in mouse kidneys.

Br J Pharmacol 2019 Apr 8. Epub 2019 Apr 8.

Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.

Background And Purpose: Both innate immunity and renin-angiotensin system (RAS) play important roles in the pathogenesis of diabetic nephropathy (DN). Myeloid differentiation factor 2 (MD2) is a co-receptor of toll-like receptor 4 (TLR4) in innate immunity. While TLR4 has been reported to mediate the development of DN, the role of MD2 in DN has not been characterized, and it also remains unclear whether MD2/TLR4 signaling pathway is associated with RAS activation in diabetes. Read More

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http://dx.doi.org/10.1111/bph.14687DOI Listing
April 2019
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Elabela protects against podocyte injury in mice with streptozocin-induced diabetes by associating with the PI3K/Akt/mTOR pathway.

Peptides 2019 Apr 5. Epub 2019 Apr 5.

Department of Nephrology, Second Hospital of Jilin University, Changchun 130041, China. Electronic address:

Diabetic nephropathy is a common complication of diabetes characterized by an increased rate of protein excretion in urine and kidney function loss. Elabela is a newly discovered peptide whose role in the regulation of diabetes is the major focus of this research. We established an in vivo model of Type 1 diabetes mellitus by injecting mice intraperitoneally with streptozotocin. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.04.005DOI Listing
April 2019
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P53/NRF2 mediates SIRT1's protective effect on diabetic nephropathy.

Biochim Biophys Acta Mol Cell Res 2019 Apr 6;1866(8):1272-1281. Epub 2019 Apr 6.

Department of Toxicology and Nutrition, School of Public Health, Shandong University, 44 Wenhua Xi Rd., Jinan, Shandong 250012, China. Electronic address:

Diabetic nephropathy (DN) is the leading cause of end stage renal disease, posing a severe threat to public health. Previous studies reported the protective role of sirtuin 1 (SIRT1) in DN, encouraging the investigation of more potent and specific SIRT1 activators. SRT2104 is a novel, first-in-class, highly selective small-molecule activator of SIRT1, with its effect and mechanism unknown on DN. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.04.006DOI Listing
April 2019
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PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy.

J Cell Mol Med 2019 Apr 6. Epub 2019 Apr 6.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Diabetic nephropathy (DN) is a chronic inflammatory disease triggered by disordered metabolism. Recent studies suggested that protein tyrosine phosphatase non-receptor type 2 (PTPN2) could ameliorate metabolic disorders and suppress inflammatory responses. This study investigated PTPN2's role in modulating DN and the possible cellular mechanisms involved. Read More

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http://dx.doi.org/10.1111/jcmm.14304DOI Listing
April 2019
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Urine exosomal ceruloplasmin: a potential early biomarker of underlying kidney disease.

Clin Exp Nephrol 2019 Apr 6. Epub 2019 Apr 6.

Division of Nephrology, John H. Stroger, Jr. Hospital of Cook County, 1950 West Polk Street, Suites 5-56, Professional Building, Chicago, IL, 60612, USA.

Background: Previously we found that kidney tissue and urinary exosomes from patients of diabetic kidney disease showed high levels of ceruloplasmin (CP). Because CP is an acute-phase protein of kidney origin, it could be an early marker of many other kidney diseases. To investigate this hypothesis, we first measured urine exosomal and kidney expression of CP in non-diabetic chronic kidney disease (CKD) patients (membranous nephropathy, focal segmental glomerulosclerosis, lupus nephritis and IgA nephropathy) followed by a longitudinal study in rat passive Heymann nephritis (PHN), a model of human membranous nephropathy. Read More

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http://dx.doi.org/10.1007/s10157-019-01734-5DOI Listing
April 2019
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Glycemic Control and Long-term Complications in Pediatric Onset Type 1 Diabetes Mellitus: A Single-center Experience from Northern India.

Indian Pediatr 2019 Mar;56(3):191-195

Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India. Correspondence to: Dr Vijayalakshmi Bhatia, Professor, Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, Uttar Pradesh, India.

Objective: To study glycemic control, mortality and long-term complications in children with type 1 diabetes (T1D).

Design: Cross-sectional study.

Setting: Referral centre at a government teaching hospital. Read More

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March 2019
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Association between polymorphism rs2032487 in the non-muscle myosin heavy chain IIA gene (MHY9) and chronic kidney disease secondary to type 2 diabetes mellitus in a population of the Canary Islands.

Endocrinol Diabetes Nutr 2019 Apr 4. Epub 2019 Apr 4.

Servicio de Nefrología, Hospital Universitario Insular, Las Palmas de Gran Canaria, España.

Introduction: Certain polymorphisms in the non-muscle myosin IIA (MYH9) and apolipoprotein L1 (APOL1) genes have been associated to chronic kidney disease (CKD) in different populations. This study examined the association between the MHY9 rs2032487 and APOL1 rs73885319 polymorphisms and advanced CKD related to type 2 diabetes mellitus (T2DM) in a population of Gran Canaria (Canary Islands, Spain).

Patients And Methods: Polymorphisms were genotyped in 152 patients with advanced CKD (estimated glomerular filtration rate [eGFR]<30mL/min/1. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S25300164193003
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http://dx.doi.org/10.1016/j.endinu.2019.01.006DOI Listing
April 2019
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Obacunone attenuates high glucose-induced oxidative damage in NRK-52E cells by inhibiting the activity of GSK-3β.

Biochem Biophys Res Commun 2019 Apr 3. Epub 2019 Apr 3.

School of Medicine, Yichun University, Yichun, 336000, China.

Hyperglycemia-induced proximal tubule injury plays a critical role in the pathogenesis of diabetic nephropathy (DN). Attenuating high glucose (HG)-induced oxidative damage in renal tubular epithelial cells has been documented to ameliorate DN. Obacunone (OB), a natural bioactive compound isolated from the Rutaceae family, has been demonstrated to possess various pharmacological effects with low toxicity. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.201DOI Listing
April 2019
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Prevalence of dyslipidemia associated with complications in diabetic patients: a nationwide study in Thailand.

Lipids Health Dis 2019 Apr 6;18(1):90. Epub 2019 Apr 6.

Department of Physiology, Phramongkutklao College of Medicine, 315 Ratchawithi Road, Ratchathewi, Bangkok, 10400, Thailand.

Background: Dyslipidemia is an important modifiable risk factor for cardiovascular disease. It is diagnosed by the presence of an abnormal lipid profile, primarily with elevated levels of plasma cholesterol, triglyceride, or both, or reduced levels of high-density lipoprotein cholesterol. However, some studies have reported increased risk of ischemic stroke with elevated low-density lipoprotein cholesterol (LDL-C) levels and increased risk of cardiovascular mortality independent of LDL-C levels in type 2 diabetes mellitus (T2DM) patients. Read More

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https://lipidworld.biomedcentral.com/articles/10.1186/s12944
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http://dx.doi.org/10.1186/s12944-019-1034-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451778PMC
April 2019
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N-Acetyl-seryl-aspartyl-lysyl-proline is a potential biomarker of renal function in normoalbuminuric diabetic patients with eGFR ≥ 30 ml/min/1.73 m.

Clin Exp Nephrol 2019 Apr 4. Epub 2019 Apr 4.

Department of Diabetology and Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa, 920-0293, Japan.

Background: A biomarker, by which we can predict alterations of renal function in normoalbuminuric diabetic patients, is not available. Here, we report that endogenous anti-fibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) represents a potential biomarker to predict alterations in eGFR in normoalbuminuric diabetic patients.

Methods: We analyzed 21 normoalbuminuric diabetic patients with eGFR ≥ 30 ml/min/1. Read More

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http://dx.doi.org/10.1007/s10157-019-01733-6DOI Listing
April 2019
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A KDM6A-KLF10 reinforcing feedback mechanism aggravates diabetic podocyte dysfunction.

EMBO Mol Med 2019 Apr 4. Epub 2019 Apr 4.

Departments of Nephrology, Chang Gung Memorial Hospital, Chiayi, Taiwan

Diabetic nephropathy is the leading cause of end-stage renal disease. Although dysfunction of podocytes, also termed glomerular visceral epithelial cells, is critically associated with diabetic nephropathy, the mechanism underlying podocyte dysfunction still remains obscure. Here, we identify that KDM6A, a histone lysine demethylase, reinforces diabetic podocyte dysfunction by creating a positive feedback loop through up-regulation of its downstream target KLF10. Read More

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http://dx.doi.org/10.15252/emmm.201809828DOI Listing

Modulating the gut microbiota and inflammation is involved in the effect of Bupleurum polysaccharides against diabetic nephropathy in mice.

Int J Biol Macromol 2019 Apr 1;132:1001-1011. Epub 2019 Apr 1.

Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address:

Dysbiosis of gut microbiota and low grade inflammation has gradually become a highly potential therapeutic agent for diabetic nephropathy (DN). It has been reported that a large number of polysaccharides have positive effects on DN, including Bupleurum polysaccharides. However, the mechanism remained unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130193030
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http://dx.doi.org/10.1016/j.ijbiomac.2019.03.242DOI Listing
April 2019
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Diabetic Nephropathy Following Posttransplant Diabetes Mellitus.

Exp Clin Transplant 2019 04;17(2):138-146

From the Department of Dialysis and Transplantation, Urology Nephrology Center, Mansoura University, Mansoura, Egypt.

Diabetic nephropathy is one of the main long-term diabetic microangiopathies that can complicate type 1 and 2 and other secondary forms of diabetes mellitus, including posttransplant diabetes mellitus. Posttransplant diabetes mellitus was initially reported in the 1960s, with case reports of recurrent and de novo diabetic nephropathy after kidney transplant reported in the early 2000s, mostly as a result of same-risk and precipitating factors of diabetic nephropathy as in native kidneys. The disease may appear early in view of the hyperfiltration risk of being a single grafted kidney. Read More

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http://dx.doi.org/10.6002/ect.2018.0157DOI Listing
April 2019
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Traditional Chinese medicine use is associated with lower end-stage renal disease and mortality rates among patients with diabetic nephropathy: a population-based cohort study.

BMC Complement Altern Med 2019 Apr 3;19(1):81. Epub 2019 Apr 3.

Department of Mathematics, University of Toronto, Toronto, Ontario, Canada.

Background: Diabetic nephropathy (DN) is a common complication of diabetes mellitus (DM) that imposes an enormous burden on the healthcare system. Although some studies show that traditional Chinese medicine (TCM) treatments confer a protective effect on DN, the long-term impact remains unclear. This study aims to examine end-stage renal disease (ESRD) and mortality rates among TCM users with DN. Read More

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http://dx.doi.org/10.1186/s12906-019-2491-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448220PMC
April 2019
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Role of Nampt-Sirt6 Axis in Renal Proximal Tubules in Extracellular Matrix Deposition in Diabetic Nephropathy.

Cell Rep 2019 Apr;27(1):199-212.e5

Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160-8582, Japan.

Nicotinamide adenine dinucleotide (NAD) metabolism plays a critical role in kidneys. We previously reported that decreased secretion of a NAD precursor, nicotinamide mononucleotide (NMN), from proximal tubules (PTs) can trigger diabetic albuminuria. In the present study, we investigated the role of NMN-producing enzyme nicotinamide phosphoribosyltransferase (Nampt) in diabetic nephropathy. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.03.024DOI Listing
April 2019
2 Reads