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Cell Physiol Biochem 2018 7;51(5):2250-2261. Epub 2018 Dec 7.

Division of Cardiovascular Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background/aims: Diabetes is associated with increased incidence of myocardial dysfunction, which is partly characterized by interstitial and perivascular fibrosis. Cardiac fibroblasts have been identified as an important participant in the development of cardiac fibrosis. Exposure of cultured cardiac fibroblasts to high glucose resulted in increased collagen synthesis. Read More

Med Princ Pract 2018 Dec 10. Epub 2018 Dec 10.

Objective: Diabetic complications involve multiple pathological pathways, including hyperglycemia-induced oxidative stress and inflammation. Combination therapy is usually employed to improve treatment outcomes and to lower potential adverse effects. In this study, we evaluated the effects of antidiabetic and antihypertensive agents, glibenclamide (GLI) and losartan (LT), on diabetes-associated metabolic changes in rats. Read More

Biomed Pharmacother 2018 Dec 8;110:609-617. Epub 2018 Dec 8.

Mehmet Akif Ersoy University, Faculty of Veterinary Medicine, Department of Pathology, Burdur, Turkey.

Background: Diabetes mellitus become an epidemic problem throughout the world. Relation of the diabetes with diet is known. Some evidence is reported about mother died and risk of diabetes in babies during the life related with gestational diabetes. Read More

Biomed Pharmacother 2018 Dec 7;110:561-570. Epub 2018 Dec 7.

Department of Pharmacology, Ningxia Medical University, Yinchuan, 750004, China; Ningxia Hui Medicine Modern Engineering Research Center and Collaborative Innovation Center, Ningxia Medical University, Yinchuan, 750004, China. Electronic address:

Spermatogenic dysfunction is a common complication in men with diabetes and is the most important manifestation of diabetes-related male reproduction damage. Astragalin (AG) is one of the main flavonoids from Cuscuta chinensis, which has rich pharmacological activities. This study aimed to establish whether AG may contribute to the recovery from spermatogenic dysfunction. Read More

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Nov 28;1104:256-261. Epub 2018 Nov 28.

Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Carinagasse 47, A-6800 Feldkirch, Austria; Private University of the Principality of Liechtenstein, Triesen, Liechtenstein; Medical Central Laboratories, A-6800 Feldkirch, Austria.

Breath analysis offers a non-invasive and rapid diagnostic method for detecting various volatile organic compounds that could be indicators for different diseases, particularly metabolic disorders including type 2 diabetes mellitus. The development of type 2 diabetes mellitus is closely linked to metabolic dysfunction of adipose tissue and adipocytes. However, the VOC profile of human adipocytes has not yet been investigated. Read More

Neuroscience 2018 Dec 8. Epub 2018 Dec 8.

Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address:

Peripheral diabetic neuropathy (PDN) manifests in 50-60% of type I and II diabetic patients and is the major cause of limb amputation. Adequate therapy for PDN is a current challenge. There are evidences that the activation of the P2X4 receptor (P2X4R) expressed on microglial cells of the central nervous system takes part in the development of neuropathic pain. Read More

Int J Biol Macromol 2018 Dec 8. Epub 2018 Dec 8.

Graduate School of Fisheries Science and Environmental Studies, Nagasaki University, Nagasaki 852-8521, Japan. Electronic address:

A sulfated polysaccharide ascophyllan inhibited α-glucosidase in a concentration dependent manner, and >90% activity was inhibited at 1.0 mg/mL. The inhibitory activity was much higher than that of acarbose. Read More

J Pharm Pharmacol 2018 Dec 7. Epub 2018 Dec 7.

Department of Traditional Chinese Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Objectives: The aim of this study was to evaluate the neuroprotective effects of SalB on high glucose (HG)-induced excessive autophagy and apoptosis in vitro.

Methods: The proliferation and apoptosis of RSC96 cells were determined using the MTT assay and flow cytometry, respectively. Western blot analysis was performed to examine the expression of autophagy and apoptosis-related proteins. Read More

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Physiology, Faculty of Medicine, Cairo University, Giza, Egypt.

Wnt/β-catenin signaling pathway plays a crucial role in diabetic cardiomyopathy (DCM), thus we aimed at investigating the effect of one therapeutic approach with resveratrol (RSV) given systemically and combined treatment of RSV with mesenchymal stem cells (MSCs) that was either RSV-preconditioned or not on Wnt/β-catenin signaling pathway in streptozotocin-induced DCM, and to evaluate effects of RSV preconditioning on MSCs therapeutic potential. The rats were divided into control (C, n = 8), diabetic (DM, n = 8), diabetic treated with systemic RSV (DM-RSV, n = 8), diabetic treated with RSV and nonconditioned MSCs (DM-RSV-MSCs, n = 8), diabetic treated with RSV and RSV-incubated with MSCs (DM-RSV-MSCc, n = 8) and diabetic treated with RSV-conditioned MSCs (DM-MSCc, n = 8). Echocardiography (Echo) showed significant improvement of cardiac functions in all groups treated with RSV either systemic or added in culture media. Read More

Diabet Med 2018 Dec 7. Epub 2018 Dec 7.

Departments of Endocrinology and Internal Medicine.

Aim: Whether or not Roux-en-Y gastric bypass (RYGB) and the derived metabolic improvements are beneficial to diabetic retinopathy is controversial. We aimed to determine the presence and development of retinopathy in individuals with obesity and Type 2 diabetes treated by RYGB compared with non-operated controls, and to determine the role of diabetes remission.

Methods: We graded fundus photography using the Wisconsin Epidemiologic Study of Diabetic Retinopathy in 96 individuals with obesity and Type 2 diabetes treated by RYGB 6 years after surgery compared with 48 non-operated controls. Read More

Bioessays 2018 Dec 11:e1800075. Epub 2018 Dec 11.

Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, 14203, USA.

The Liver kinase B1 with its downstream target AMP activated protein kinase (LKB1-AMPK), and the key nutrient sensor mammalian target of rapamycin complex 1 (mTORC1) form two signaling systems that coordinate metabolic and cellular activity with changes in the environment in order to preserve homeostasis. For example, nutritional fluctuations rapidly feed back on these signaling systems and thereby affect cell-specific functions. Recent studies have started to reveal important roles of these strategic metabolic regulators in Schwann cells for the trophic support and myelination of axons. Read More

J Physiol 2018 Dec 7. Epub 2018 Dec 7.

The British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh, United Kingdom, EH16 4TJ.

Key Points Summary: Type 1 diabetes mellitus increases cardiovascular risk: hypertension amplifies this risk. Pressure natriuresis regulates long-term blood pressure. We induced type 1 diabetes in rats by streptozotocin injection and after three weeks demonstrated a substantial impairment of pressure natriuresis: acute increases in blood pressure did not increase renal medullary blood flow, and tubular sodium reabsorption was not downregulated. Read More

Pediatr Diabetes 2018 Dec 10. Epub 2018 Dec 10.

Karolinska Institutet, Department of Clinical Science, Intervention and Technology, Division of Pediatrics, Stockholm, Sweden.

Background: Impaired fasting glycemia (IFG) reflects an intermediate hyperglycemia in the fasting state. Which fasting glucose level that actually is associated with impaired insulin-glucose homeostasis in children and adolescents with obesity is unknown.

Objective: The aim of this study was to investigate how insulin and glucose homeostasis in children and adolescents with obesity in Sweden varies within different fasting glucose levels in the non-diabetic range. Read More

J Pharm Pharmacol 2018 Dec 7. Epub 2018 Dec 7.

Department of Endocrinology, Changzhou Wujin People's Hospital, Changzhou, China.

Objectives: Lipopolysaccharide (LPS) contributed to the development and progression of type 2 diabetes mellitus (T2D), while TLR4 is reported to mediate the LPS-induced inflammation in macrophages. However, the potential molecular mechanisms for TLR4-mediated macrophages activation in T2D have not yet to be fully clarified.

Methods: Type 2 diabetes models in C57BL/6J mice were generated by a combination administration of streptozotocin (STZ) and a high-fat diet (HFD). Read More

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Diabetic nephropathy is the leading cause of renal failure worldwide. This debilitating disorder has several underlying pathophysiologic mechanisms, and therefore a variety of pharmacologic agents have been developed to prevent or treat diabetic nephropathy; however, synthetic drugs may possess unfavorable side effects. In response to this, the global use of herbal-based pharmacologic agents is increasing among diabetic patients. Read More

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Lankenau Institute for Medical Research, Wynnewood, Pennsylvania.

Neovascularization in cancer or retinopathy is driven by pathological changes that foster abnormal sprouting of endothelial cells. Mouse genetic studies indicate that the stress-induced small GTPase RhoB is dispensable for normal physiology but required for pathogenic angiogenesis. In diabetic retinopathy, retinopathy of prematurity (ROP) or age-related wet macular degeneration (AMD), progressive pathologic anatomic changes and ischemia foster neovascularization are characterized by abnormal sprouting of endothelial cells. Read More

J Diabetes Investig 2018 Dec 11. Epub 2018 Dec 11.

Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.

Aims/introduction: SGLT2 inhibitors reduce body weight (BW) by creating a negative energy balance. Previous reports have suggested that this BW reduction is mainly loss of body fat and that ~20% of the reduction is lean mass. However, the effects of SGLT2 inhibitors on BW and body composition remain unclear. Read More

Clin Genet 2018 Dec 7. Epub 2018 Dec 7.

Department of Cardiovascular Ultrasound, The First Affiliated Hospital of China Medical University, Shenyang, China.

Diabetes mellitus (DM) has become the third major chronic non-communicable disease affecting global public health, following cancer and cardiovascular and cerebrovascular diseases. Although previous studies have found a correlation between microRNA (miRNA) and the development of DM, thus far, most reviews have focused on the studies describing the changes in miRNA expression profiles and the mechanisms by which miRNAs-induce DM. However, reviews summarizing the effect of miRNA single nucleotide polymorphisms (SNP) on the developmental stages of DM and its complications are still needed. Read More

J Diabetes Investig 2018 Dec 9. Epub 2018 Dec 9.

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Chinese PLA Medical School, 28 Fuxing Road, Beijing, 100853, China.

Aims: The aim of the study is to identify candidate differentially expressed genes (DEGs) and pathways using bioinformatics analysis and improve our understanding of the cause and potential molecular events of diabetic nephropathy (DN).

Materials And Methods: Two cohort profile datasets (GSE30528 and GSE33744) were integrated and used for deep analysis. We sorted DEGs and analyzed differential pathway enrichment. Read More

Diabetes Obes Metab 2018 Dec 11. Epub 2018 Dec 11.

Functional Metabolism Group, Singapore Bioimaging Consortium, Agency for Science, Technology, and Research, Singapore.

Aims: To investigate the effects of long-term low-carbohydrate low-protein ketogenic diet (KD) on cardiac metabolism and diabetic cardiomyopathy status in lean diabetic Goto-Kakizaki (GK) rats.

Materials And Methods: Diabetic GK rats were fed with KD for 62 weeks. Cardiac function and metabolism were assessed using magnetic resonance imaging and C magnetic resonance spectroscopy ( C-MRS), at rest and under dobutamine stress. Read More

J Med Imaging Radiat Oncol 2018 Dec 10. Epub 2018 Dec 10.

Department of Nuclear Medicine, Nuclear Medicine, Oncology and Radiotherapy Institute (NORI), Islamabad, Pakistan.

Introduction: The diagnosis of diabetic foot osteomyelitis is crucial and challenging for the proper management of diabetic foot. Tc labelled Ceftizoxime was used as a non-invasive diagnostic agent for diabetic foot osteomyelitis.

Methods: Ceftizoxime [CFT], a third generation cephalosporin, was used in a simple and direct method for the synthesis of TcO labelled infection imaging agent with stannous chloride as reducing agent. Read More

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Endocrinology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Asymmetric dimethylarginine (ADMA) plays a vital role in the regulation of insulin sensitivity and has been shown as a potential marker for various disease, including type 2 diabetes mellitus (DM2). However, the correlation between ADMA and impaired glucose tolerance (IGT) and obesity has not been studied. A total of 195 subjects were involved in our study. Read More

J Pharm Pharmacol 2018 Dec 10. Epub 2018 Dec 10.

Department of Pharmacology, Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.

Objectives: The role of nuclear factor-2 erythroid related factor-2 (Nrf2) activator, berberine (BBR), has been established in rat model of streptozotocin induced diabetic neuropathy. Around 30-40% of cancer patients, on paclitaxel (PTX) chemotherapy develop peripheral neuropathy. The present study was contemplated with the aim of establishing the neuropathy preventive role of BBR, in paclitaxel induced peripheral neuropathy model in rats. Read More

Int Urol Nephrol 2018 Dec 7. Epub 2018 Dec 7.

Department of Endocrinology, Southwest Hospital, Third Military Medical University (Army Medical University), 29 Gaotanyan Street, Chongqing, 400038, China.

Purpose: To assess the role of serum pigment epithelium-derived factor (PEDF) in the occurrence and development of proteinuria and renal dysfunction and determine its relevant signaling pathway.

Methods: We analyzed serum PEDF, creatinine, the urinary albumin-to-creatinine ratio, and renal morphology of normal or streptozotocin (STZ)-induced diabetic mice, before and after treatment with PEDF. In vitro, podocytes were stimulated with PEDF under normal or high-glucose conditions; permeability was measured by the transwell assay with fluorescein isothiocyanate (FITC)-dextran; and F-actin cytoskeleton was analyzed by phalloidin staining. Read More

Int Ophthalmol 2018 Dec 7. Epub 2018 Dec 7.

Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Purpose: To evaluate the effect of topical sodium hyaluronate (SH) 0.18% treatment on corneal epithelial healing after epithelial debridement in pars plana vitrectomy in diabetic patients.

Method: This is prospective and randomized clinical trial. Read More

Breast Cancer Res Treat 2018 Dec 7. Epub 2018 Dec 7.

Division of Oncology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.

Purpose: To investigate the efficacy of metformin (M) plus chemotherapy versus chemotherapy alone in metastatic breast cancer (MBC).

Methods: Non-diabetic women with HER2-negative MBC were randomized to receive non-pegylated liposomal doxorubicin (NPLD) 60 mg/m + cyclophosphamide (C) 600 mg/m × 8 cycles Q21 days plus M 2000 mg/day (arm A) versus NPLD/C (arm B). The primary endpoint was progression-free survival (PFS). Read More

Exp Suppl 2018 ;108:177-210

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, Australia.

Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kidney diseases. In addition to leukocyte-derived inflammasomes, renal tissue cells express functional inflammasome components. Read More

Curr Med Sci 2018 Dec 7;38(6):968-975. Epub 2018 Dec 7.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

With an increasing incidence, diabetic retinopathy is one of the most important complications of diabetes mellitus (DM) and is also known as one of the major reasons of adult acquired blindness. It is widely accepted that the visual impairment of diabetic patients results from retinal microvascular changes. However, recent clinical experimental and neuroimaging studies suggest that the visual impairment of diabetic patients is also related to the pathophysiological changes of different parts of the visual pathway in diabetic retinopathy. Read More

J Mol Med (Berl) 2018 Dec 8. Epub 2018 Dec 8.

Buchanan Ocular Therapeutics Unit, Department of Ophthalmology and the New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand.

Diabetic retinopathy (DR) is a vascular disease of the neuroretina characterised by hyperglycaemia and inflammation. Current DR therapies target late-stage vascular defects and there is evidence to suggest that they contribute to geographic atrophy and retinal ganglion cell death long term. Therefore, alternative treatments that target common upstream disease mechanisms are needed. Read More

Methods Mol Biol 2019 ;1916:195-201

Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.

This chapter presents characterization of the db/db mouse model of type 2 diabetes. The protocol describes generation of the mice along with measurements of physical characteristics such as body weight and body composition, and behaviours including food and water consumption. Such a procedure can also be used for omics-based analyses of brain tissues to investigate the potential use of db/db mouse model in neuropsychiatric research. Read More

Mol Med Rep 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical Informatics, School of Medicine, Nantong University, Nantong, Jiangsu 226001, P.R. China.

Diabetic retinopathy (DR) is a severe microvascular complication of diabetes and the primary cause of vision loss in diabetic patients. Previous research has revealed that long non‑coding RNAs (lncRNAs) and microRNAs (miRNAs) play pivotal roles in the pathogenesis of DR. However, the roles of lncRNA‑miRNA‑mRNA interactions in DR are poorly understood. Read More

Mol Med Rep 2018 Nov 29. Epub 2018 Nov 29.

Outpatient Department, Chinese PLA General Hospital, Beijing 100853, P.R. China.

Mitochondrial homeostasis is a highly regulated process that serves a critical role in the maintenance of renal structure and function. The growing interest in the field of mitochondrial homeostasis promises to provide more information regarding the mechanisms involved in diabetic renal fibrosis, and aid in the development of novel strategies to combat the disease. In the present study, the effects of melatonin on renal damage in mice with diabetes were evaluated and the underlying mechanisms were investigated. Read More

Eur Heart J Cardiovasc Imaging 2018 Dec 7. Epub 2018 Dec 7.

Complications Research, Steno Diabetes Center Copenhagen, Niels Steensens Vej 2, Gentofte, Denmark.

Aims: To evaluate myocardial flow reserve (MFR) and coronary artery calcium (CAC) in persons with Type 1 diabetes with or without albuminuria and in non-diabetic controls. MFR reflects the function of large epicardial arteries and myocardial microcirculation. CAC represents structural aspects of atherosclerosis. Read More

Fam Pract 2018 Dec 10. Epub 2018 Dec 10.

Department of Economics, International College of Management, Sydney, Australia.

Background: There has been a shift in worldwide disease burden from infections to non-communicable diseases, especially type 2 diabetes (T2D). Behavioural change and self-management are key to optimal T2D control. Several universal models of diabetic care have been proposed to help explain the dimensions of T2D self-care such as medication adherence, physical activity, diet and patient-doctor interaction. Read More

Rev Med Chil 2018 Jul;146(7):929-932

Unidad de Diabetes, Hospital San Juan de Dios, Santiago, Chile.

We report a 21 years old woman, without offspring, with diabetes mellitus diagnosed at 17 years of age, without ketosis or weight loss. Her body mass index was 18 kg/m2. Her C peptide was normal (2. Read More

Rev Med Chil 2018 Jul;146(7):876-884

Servicio de Farmacia, Hospital La Ligua, La Ligua, Chile.

Background: In 2013 the Chilean regulatory sanitary agency issued a warning concerning dose adjustment and use restriction to avoid severe adverse effects of metoclopramide such tardive dyskinesia.

Aim: To study dyskinesia type adverse effects in a population using metoclopramide.

Material And Methods: A cross sectional observational study was conducted among patients pertaining to palliative care and diabetes mellitus programs and consuming 10 mg/day or more of metoclopramide. Read More

Rev Med Chil 2018 Aug;146(8):890-893

Servicio de Oftalmología, Hospital del Salvador, Santiago, Chile.

Background: Primary care units of ophtalmology (UAPO) were incorporated in 2003 into the healthcare system of the Ministry of Health, in response to the high demand for hospital care. Three of these primary care units were incorporated to provide a network care with the ophthalmology service of a tertiary care hospital.

Aim: To report the public health impact of networking. Read More

Rom J Morphol Embryol 2018 ;59(3):895-902

Department of Physiopathology, Faculty of Medicine, "Titu Maiorescu" University, Bucharest, Romania; Department of Family Medicine, University of Medicine and Pharmacy of Craiova, Romania;

Our study included a total of 259 patients with diabetes, who were admitted to the Department of Plastic Surgery and Reconstructive Microsurgery of the Emergency County Hospital of Piteşti, Romania, in 2016, with the diagnosis of "diabetic foot". Of the 259 patients, 55 (21.23%) were diagnosed with type 1 diabetes, and the remaining 204 (78. Read More

Rom J Morphol Embryol 2018 ;59(3):699-702

Discipline of Pharmacology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;

Diabetes mellitus is the leading cause of non-traumatic amputations worldwide. Ulcer of the diabetic foot is one of the most prevalent lesions of diabetic patients and it occurs in the natural evolution of the disease as a tardive complication. Neuropathy is the main determinant of foot ulcer. Read More

Analyst 2018 Dec 11. Epub 2018 Dec 11.

School of Materials Science and Engineering, Linyi University, Linyi 276005, China.

Based on the inner filter effect and charge transfer dual response mechanism, a dual response ratiometric fluorescent probe (D-RFP) with two reversible signal changes for sensing H2O2 and glucose was developed. The D-RFP was proposed by embedding glycine-derived carbon dots (CDs) (λem = 400 nm) into silica nanoparticles and covalently linking CdTe quantum dots (QDs) (λem = 600 nm) onto the surface of silica nanoparticles. When silver nanoparticles (Ag NPs) were mixed with D-RFP, the fluorescence intensity of CDs can be quenched by Ag NPs via the inner filter effect. Read More

J Diabetes Res 2018 11;2018:1390418. Epub 2018 Nov 11.

Division of Nephrology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Background/aims: It is known that chronic low-grade inflammation contributes to the initiation and development of both diabetes and diabetic nephropathy (DN), so we designed this study to investigate the role of P2X7R and NLRP3 inflammasome in DN pathogenesis and the antagonistic effects of artificially cultivated (ACOS).

Methods: A rat model of DN caused by high-fat-diet feeding and low-dose streptozotocin injection and a mouse podocyte injury model induced by high-glucose (HG) stimulation were established, and the intervention effects of ACOS on them were observed. The biological parameters of serum and urine and the pathological manifestations of kidney tissue were examined. Read More

Nurs Open 2019 Jan 14;6(1):197-202. Epub 2018 Sep 14.

Department of Nursing Babcock University Ilisha Remo Ogun State Nigeria.

Aim: The study aim was to determine the level of medication adherence, patient medication belief and to determine the correlation between medication belief and medication adherence among patients with diabetes. This is to find out whether medication belief of patient could enhance medication adherence which in turn would promote effective management of diabetic mellitus in Nigeria.

Background: The World Health Organization (WHO, 2015) estimated that over 366 million people are affected. Read More

Diabetol Metab Syndr 2018 4;10:89. Epub 2018 Dec 4.

2Department of Clinical Pharmacy and Pharmacy Practice, Translational Research Unit, Faculty of Pharmacy, Misr International University, Cairo, Egypt.

The current study aims to investigate the antidiabetic efficacy of camel milk-derived lactoferrin and potential involvement of PPAR-γ and SIRT-1 via TLR-4/NFκB signaling pathway in obese diabetic pediatric population. Sixty young obese patients with type 2 diabetes were selected from the Pediatric Endocrine Metabolic Unit, Cairo University and were randomly divided among two age and sex-matched groups so as to receive either standard therapy without lactoferrin in one arm or to be treated with oral lactoferrin capsules (250 mg/day, p.o) for 3 months in the other arm. Read More

Diabetol Metab Syndr 2018 4;10:88. Epub 2018 Dec 4.

Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505 Japan.

Background: Recently, an integrated network analysis has revealed dysregulation in the metabolism of mannose, a glucose epimer, in severely obese individuals without diabetes. In addition, fasting plasma mannose levels (M) are associated with insulin resistance independent of BMI. Since the association between mannose and insulin sensitivity (IS) in those with impaired glucose tolerance remains unknown, we aimed to investigate this association in individuals without severe obesity but with varying degrees of glucose tolerance. Read More

Diabetol Metab Syndr 2018 27;10:86. Epub 2018 Nov 27.

2Social Determinants of Health Research Center, Public Health School, Ahvaz Jundishapur University of Medical Sciences, 61375-15751 Ahvaz, Iran.

Objectives: Diabetes is a chronic illness which requires lifelong self-care behaviors. The objective of the present research was to investigate the association of self-efficacy, attitude and social support with adherence to diabetes self-care behavior.

Materials And Methods: In this cross-sectional study conducted in 2017, 403 diabetic patients of Zarandieh, Iran participated. Read More

Evid Based Complement Alternat Med 2018 11;2018:7191035. Epub 2018 Nov 11.

Medical Research Unit in Biochemistry, Specialties Hospital, National Medical Center SXXI, Instituto Mexicano del Seguro Social, Av. Cuauhtémoc 330, Col. Doctores, Del. Cuauhtémoc, CP 06720, CDMX, Mexico.

(L.) G. () is a medicinal plant used traditionally for diabetes mellitus control. Read More

Yale J Biol Med 2018 Sep 7;91(3):355. Epub 2018 Dec 7.

[This corrects the article on p. 161 in vol. 91, PMID: 29962922. Read More

Glob J Obes Diabetes Metab Syndr 2018 27;5(2):008-14. Epub 2018 Jul 27.

Department of Radiation Oncology, Department of Medicine, Division of Endocrinology, SUNY-Downstate, Brooklyn, NY 11203, USA.

The association between Diabetes and cancer has been known for decades with obesity and insulin resistance being postulated as the main underlying risk factors for both disorders. With rise of the epidemic of obesity in the USA and around the globe, there has been a rise in diabetes that is currently reaching epidemic proportions. Diabetes is known to be associated with increased risk of several types of malignancy including breast, cervical, pancreatic and colon cancer. Read More

Am J Med Case Rep 2018 7;6(9):173-179. Epub 2018 Oct 7.

Division of Cardiovascular Disease and Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, New York, U.S.A- 11203.

Brugada syndrome is a rare cardiac arrhythmia which is associated with right bundle branch block pattern (RBBB) and ST-segment elevation in right precordial leads. SCNA5 mutation is the most common genetic abnormality associated with Brugada syndrome. Brugada pattern not related to genetic mutations has been previously reported in the setting of fever, metabolic conditions, lithium use, marijuana and cocaine abuse, ischemia and pulmonary embolism, myocardial and pericardial diseases. Read More

Res Rep Urol 2018 16;10:219-225. Epub 2018 Nov 16.

Department of Surgery, Division of Urology, Duke University Medical Center, Durham, NC, USA,

Purpose: Diabetes is a grave and progressive condition characterized by debilitating complications. Diabetic bladder dysfunction (DBD) is a very common complication with no specific treatments currently available. Unlike other tissues affected by this disease, the bladder is subjected to two independent insults; 1) polyuria, created by the osmotic effects of glucose in the urine, and 2) hyperglycemia itself. Read More