Endocr Pract 2022 Jun 7. Epub 2022 Jun 7.
Staff Specialist Intensive Care Unit, Royal Darwin Hospital, 105 Rocklands Dr, Tiwi NT 0810, Australia; Associate Professor Flinders University, Sturt Rd, Bedford Park SA 5042 Australia; Honorary Clinical Fellow, Menzies School of Health Research, Royal Darwin Hospital Campus, 105 Rocklands Dr, Tiwi NT 0810, Australia.
Objective: International guidelines for the treatment of diabetic ketoacidosis (DKA) advise against rapid changes in osmolarity and glucose, but the optimal rates of correction are unknown. We aimed to evaluate rates of change in tonicity and glucose in intensive care patients with DKA and their relationship with mortality and altered mental status.
Methods: Observational cohort study using two publicly available databases of USA intensive care patients (Medical Information Mart for Intensive Care-IV and eICU), evaluating adults with DKA and associated hyperosmolarity (baseline Osm≥300mosm/L). Read More