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Can Vet J 2019 Apr;60(4):399-404

Alamo Feline Health Center, San Antonio, Texas, USA (Restine, Norsworthy); School of Veterinary Medicine and School of Medicine, University of California-Davis, Davis, California, USA (Kass).

This study evaluated the outcome of cats with diabetes mellitus treated with a loose-control approach using protamine zinc insulin and identified factors that influence the likelihood of remission and survival in these cats. A total of 185 client-owned domestic cats were followed until death, lost to follow-up, or the end of the 11-year study. These cats were treated primarily basing insulin dose adjustments on clinical response. Read More

Lancet Child Adolesc Health 2019 Apr 12. Epub 2019 Apr 12.

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

The effect of type 1 diabetes on the developing brain is a topic of primary research interest. A variety of potential dysglycaemic insults to the brain can cause cellular and structural injury and lead to altered neuropsychological outcomes. These outcomes might be subtle in terms of cognition but appear to persist into adult life. Read More

Exp Mol Pathol 2019 Apr 12. Epub 2019 Apr 12.

Department of Neurology, University of Maryland, School of Medicine, Baltimore, MD, USA. Electronic address:

There is increasing awareness that in addition to the metabolic crisis of diabetic ketoacidosis (DKA) caused by severe insulin deficiency, the immune inflammatory response is likely an active multicomponent participant in both the acute and chronic insults of this medical crisis, with strong evidence of activation for both the cytokine and complement system. Recent studies report that the matrix metalloproteinase enzymes and their inhibitors are systemically activated in young Type 1 diabetes mellitus (T1D) patients during DKA and speculate on their involvement in blood-brain barrier (BBB) disruption. Based on our previous studies, we address the question if matrix metalloproteinase 9 (MMP9) is expressed in the brain in the fatal brain edema (BE) of DKA. Read More

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Klinische Abteilung für Endokrinologie und Stoffwechsel, Universitätsklinik für Innere Medizin III, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.

Diabetic ketoacidosis (DKA) and the hyperglycemic hyperosmolar state (HHS) represent potentially life-threatening situations in adults. Therefore, rapid comprehensive diagnostic and therapeutic measures with close monitoring of vital and laboratory parameters are required. The treatment of DKA and HHS is essentially the same and replacement of the mostly substantial fluid deficit with several liters of a physiological crystalloid solution is the first and most important step. Read More

Wien Klin Wochenschr 2019 Apr 12. Epub 2019 Apr 12.

Department für Pädiatrie 1, Medizinische Universität Innsbruck, Anichstraße 35, 6020, Innsbruck, Österreich.

In contrast to adults, type 1 diabetes mellitus (T1D) is the most frequent form of diabetes in childhood and adolescence (>95%). After diagnosis the management of children and adolescents with T1D should take place in highly specialized pediatric units experienced in pediatric diabetology and not in private practices. The lifelong substitution of insulin is the cornerstone of treatment whereby modalities need to be individually adapted for patient age and the family routine. Read More

Diabetes Metab Res Rev 2019 Apr 11:e3169. Epub 2019 Apr 11.

Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Sodium-glucose cotransporter (SGLT) inhibitors added to insulin therapy have been proposed as a treatment strategy for type 1 diabetes (T1D). We thus conducted a meta-analysis of randomized controlled trials (RCTs) to assess the efficacy and adverse effects of this combination in T1D. We searched the PubMed, EMBASE, and Cochrane Library databases and ClinicalTrials. Read More

Health Psychol 2019 Apr 11. Epub 2019 Apr 11.

Department of Pediatrics.

Objective: Diabetic ketoacidosis (DKA) and elevated hemoglobin A1c (HbA1c) in youth with Type 1 diabetes (T1D) can result in significant morbidity and mortality. Elucidating the risk factors for poor glycemic control and DKA hospitalizations is crucial for the refinement and development of prevention and treatment efforts.

Method: Based on a conceptual framework, this study used path analysis to evaluate individual and family characteristics, psychosocial responses, and individual and family responses that prospectively predict the number of DKA hospitalizations and HbA1c approximately 1 year after assessment, accounting for sociodemographics. Read More

Front Neurol 2019 26;10:264. Epub 2019 Mar 26.

Department of Neurosurgery, Arrowhead Regional Medical Center, Colton, CA, United States.

Mucormycosis is a rapidly progressive, angioinvasive fungal infection that has a predilection for the paranasal sinuses and adjacent mucosa. Rhinocerebral mucormycosis (RCM) is the most common form and is known to invade the skull base and its associated blood vessels-leading to mycotic aneurysms, ischemic infarcts, and intracerebral hemorrhage. There are documented cases of mechanical thrombectomy in ischemic stroke due to RCM, however, there are no known cases that were diagnosed primarily by histological and pathological analysis of the embolus. Read More

Interact Cardiovasc Thorac Surg 2019 Apr 9. Epub 2019 Apr 9.

Department of Cardiovascular Surgery, Kitasato University School of Medicine, Sagamihara, Japan.

Sodium glucose cotransporter 2 inhibitors are currently widely used antihyperglycaemic medications that are considered to be associated with euglycaemic diabetic ketoacidosis. We report 2 cases of patients who received sodium glucose cotransporter 2 inhibitors until emergency coronary artery bypass grafting (CABG) and developed euglycaemic ketoacidosis after surgery; they were treated with sugar replenishment and insulin infusion. In one case, coronary angiography revealed a spastic change of the bypass graft possibly due to severe acidosis. Read More

BMJ 2019 Apr 9;365:l1328. Epub 2019 Apr 9.

Humanitas University Gradenigo Hospital, 8 Corso Regina Margherita, 10132 Turin, Italy.

Objective: To assess the efficacy and safety of dual sodium glucose cotransporter (SGLT) 1/2 inhibitor sotagliflozin in type 1 diabetes mellitus.

Design: Meta-analysis of randomised controlled trials.

Data Sources: Medline; Cochrane Library; Embase; international meeting abstracts; international and national clinical trial registries; and websites of US, European, and Japanese regulatory authorities, up to 10 January 2019. Read More

Am J Emerg Med 2019 Mar 27. Epub 2019 Mar 27.

Kendall Regional Medical Center, Department of Emergency Medicine, 11750 SW 40th St., Miami, FL 33175, United States of America; Nova Southeastern University College of Allopathic Medicine, Davie, FL 33328, United States of America. Electronic address:

Background: Recent data have challenged the notion that rapid intravenous fluid administration results in adverse neurologic outcomes in children with diabetic ketoacidosis (DKA). While many physicians still administer a cautious 10 cc/kg bolus of intravenous fluids for pediatric DKA patients, there may be benefits to using a larger bolus.

Methods: This was a retrospective chart review of all pediatric patients with DKA presenting to a single emergency department (ED) between 2013 and 2015. Read More

Pediatr Emerg Care 2019 Apr 4. Epub 2019 Apr 4.

Division of Biostatistics ACHRI, Department of Pediatrics, Arkansas Children's Hospital Research Institute, College of Medicine, University of Arkansas, Little Rock, AR.

Background: Suspected cerebral edema diabetic ketoacidosis (SCEDKA) is more common than perceived with symptoms including altered mentation, headache with vomiting, depressed Glasgow coma scale (GCS), abnormal motor or verbal responses, combativeness, and neurological depression. Suspected cerebral edema diabetic ketoacidosis has been associated with initial diabetic ketoacidosis (DKA) presentation and at start of DKA therapy.Cerebral oximetry (bihemispheric regional cerebral oxygen saturation [rcSO2] and cerebral blood volume index [CBVI]) can detect increased intracranial pressure (ICP)-induced altered bihemispheric cerebral physiology (rcSO2) (Crit Care Med 2006;34:2217-2223, J Pediatr 2013;163: 1111-1116, Curr Med Chem 2009;16:94-112, Diabetologia 1985;28:739-742, Pediatr Crit Care Med 2013;14:694-700). Read More

J Oncol Pharm Pract 2019 Apr 7:1078155219841116. Epub 2019 Apr 7.

Medical Oncology Department, Bakırköy Sadi Konuk Training and Research Hospital, Bakırköy, İstanbul.

Background: Immune checkpoint inhibitors are medications that activate anti-tumor responses by disrupting the inhibitory signaling to T cells. Nivolumab is an immune checkpoint inhibitor that selectively blocks the programmed cell death-1 (PD-1). Anti-PD-1 agents can breach immunologic tolerance. Read More

Indian Pediatr 2019 Mar;56(3):244-246

Department of Pediatrics, Cloudnine Children's Hospital, Bengaluru, Karnataka, India.

Background: Posterior reversible encephalopathy syndrome (PRES) is a benign disorder of reversible subcortical vasogenic cerebral edema.

Case Characteristics: A 13-yr-old girl presented 4 days after complete recovery from diabetic ketoacidosis with symptoms of headache, altered sensorium, seizures, and visual loss. There was no hypertension or biochemical abnormalities identified. Read More

BMJ Case Rep 2019 Apr 5;12(4). Epub 2019 Apr 5.

Department of Endocrinology, Herlev Hospital, Herlev, Denmark.

Diabetic euglycaemic ketoacidosis is a possible adverse effect of sodium-glucose co-transporter-2 inhibitors (SGLT2i). We report a case in which the combination of SGLT2i and a strict very low-carbohydrate diet led to severe diabetic ketoacidosis in a young Caucasian man with type 2 diabetes. Read More

Diabetes Res Clin Pract 2019 Apr 2;151:88-95. Epub 2019 Apr 2.

Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Translational and Clinical Research Unit, Misr International University, Cairo, Egypt.

Cleve Clin J Med 2019 Apr;86(4):238-239

Department of Pulmonary and Critical Care Medicine, Monmouth Medical Center, Long Branch, NJ, USA.

Acta Diabetol 2019 Apr 3. Epub 2019 Apr 3.

Department of Diabetology, Careggi Hospital, Florence, Italy.

Meta-analyses of clinical trials comparing CSII with traditional insulin injections usually show a small, but significant advantage of CSII with respect to HbA1c and risk of severe hypoglycemia. On the other hand, CSII is associated with a small, but relevant risk of ketoacidosis, mainly due to malfunction of insulin pump and/or catheter occlusion. During last time, the technology of insulin pumps and infusion sets has improved as the profound evolution in type and schemes with traditional insulin injections. Read More

BMJ 2019 04 3;365:l1226. Epub 2019 Apr 3.

Clinical Trials Research Centre, University of Liverpool, Liverpool, UK.

Objective: To compare the efficacy, safety, and cost utility of continuous subcutaneous insulin infusion (CSII) with multiple daily injection (MDI) regimens during the first year following diagnosis of type 1 diabetes in children and young people.

Design: Pragmatic, multicentre, open label, parallel group, randomised controlled trial and economic evaluation.

Setting: 15 paediatric National Health Service (NHS) diabetes services in England and Wales. Read More

Ital J Pediatr 2019 Apr 2;45(1):42. Epub 2019 Apr 2.

Department of Pediatric Endocrinology and Diabetology, Medical University of Lublin, Lublin, Poland.

Background: Hypophosphatemia has many causes, and is often encountered during DKA (Diabetic Ketoacidosis) treatment. However, it rarely requires clinical intervention.

Case Presentation: Ventricular arrhythmia was observed in a 10-year-old girl with newly diagnosed type 1 diabetes mellitus and hypophosphatemia while undergoing treatment for ketoacidosis. Read More

Diabetes Ther 2019 Apr 1. Epub 2019 Apr 1.

Department of Endocrinology, Key Laboratory of Endocrinology of National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

A 46-year-old woman presented with rash, fever, lymphadenopathy, eosinophilia and liver dysfunction. She had been treated with ornidazole for facial rosacea 2 months previously. Two weeks following presentation, she developed diabetic ketoacidosis with exhausted beta islets (2 h postprandial laboratory values: glucose 22. Read More

J Clin Med Res 2019 Apr 18;11(4):225-236. Epub 2019 Mar 18.

Department of Medicine, Jersey Shore University Medical Center, Neptune, NJ, USA.

In recent years the use of immunomodulating therapy to treat various cancers has been on the rise. Three checkpoint inhibitors have been approved by the Food and Drug Administration (ipilimumab, pembrolizumab and nivolumab). The use of these drugs comes with serious adverse events related to excessive immune activation, collectively known as immune-related adverse events (irAEs). Read More

J Diabetes Sci Technol 2019 Mar 31:1932296819838875. Epub 2019 Mar 31.

1 Division of Endocrinology and Metabolism, University of California, San Francisco, San Francisco, CA, USA.

Med Klin Intensivmed Notfmed 2019 Mar 27. Epub 2019 Mar 27.

Medizinische Klinik II, St. Joseph Krankenhaus, Wüsthoffstraße 15, 12101, Berlin, Deutschland.

A young woman with type 1 diabetes mellitus and severe diabetic ketoacidosis was treated in an intensive care unit according to the guidelines. Only a few hours after starting the therapy, rising lactate values were diagnosed in the arterial blood gas analysis. Since there were no indications for other reasons of lactatemia, an acute refeeding syndrome caused by the insulin therapy was suspected. Read More

J Diabetes Metab Disord 2018 Dec 19;17(2):143-148. Epub 2018 Sep 19.

3Universidad Pontificia Bolivariana, Calle 78b #72a-159, Antioquia, Colombia.

Background: Hyperglycemic crisis are the most serious forms of acute decompensation of diabetes mellitus and require urgent medical attention. The epidemiological data of these conditions in Latin America are scarce and in Colombia unknown, that is why we decided to describe the clinical characteristics and factors associated with the mortality of adults who presented with hyperglycemic crises in a teaching hospital in Colombia.

Materials And Methods: Retrospective cohort study of all episodes of hyperglycemic crisis treated in Pablo Tobón Uribe Hospital in a three-year period. Read More

Pan Afr Med J 2018 20;31:38. Epub 2018 Sep 20.

Service d'Endocrinologie Diabétologie et Maladies Métaboliques, Hôpital Avicenne, 125 rue de Stalingrad, 93009 Bobigny, France.

Patients with ketosis prone diabetes have been reported primarily in Africans and African Americans. At presentation, both insulin secretion and insulin action are impaired in ketosis prone diabetes patients. Fulminant diabetes is a subtype of type 1 diabetes reported mainly in the Asian populations characterized by diabetic ketosis or ketoacidosis occurring soon after the onset of hyperglycemic symptoms with inappropriately low HbA1c (< 8. Read More

Intern Med 2019 Mar 28. Epub 2019 Mar 28.

Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan.

The patient was a 71-year-old woman with aquaporin-4-antibody positive neuromyelitis optica (NMO), with no history of diabetes. On admission, although she showed an extremely elevated plasma glucose level (1,080 mg/dL), her hemoglobin A1c level was low (7.1%), which indicated the rapid progression of diabetes. Read More

Endocr Pract 2019 Mar;25(3):242-253

Objective: We aimed to determine the causes and predictors for 30-day re-admission following a hospitalization for diabetic ketoacidosis (DKA) in the United States.

Methods: This retrospective cohort study analyzed data from the National Re-admission Database. We included adult patients with a primary discharge diagnosis of DKA, from 2010 to 2014. Read More

Endocr Pract 2019 Mar;25(3):263-269

Objective: To evaluate the adequacy of the insulin dose prescribed at hospital discharge in a high-risk population and assess patient characteristics that influence insulin dose requirement in the immediate postdischarge period.

Methods: This was a retrospective study conducted at Parkland Health System. We included all patients admitted to a medical floor who received an insulin prescription at discharge and had at least one follow-up visit within 6 months of discharge. Read More

Endocr Pract 2019 Mar;25(3):226-229

Objective: Many youth with diabetes struggle to meet glycemic targets. The new ultralong duration of action of insulin degludec (iDeg) holds potential to ameliorate missed doses of basal insulin and improve glycemic control in youth with diabetes.

Methods: A retrospective chart review was undertaken of youth age 13 to <24 years in our practice with type 1 diabetes (T1D) or type 2 diabetes (T2D) who had been switched from glargine or detemir to iDeg to evaluate the impact of this transition on glycemic control. Read More

Eur J Intern Med 2019 Mar 22. Epub 2019 Mar 22.

Department of Internal Medicine F, Soroka Univerity Medical Center, Beer-Sheva, Israel.

Euglycemic DKA (eu-DKA) is a life-threatening emergency. It may occur in patients with both type 1 and type 2 DM, and characterized by milder degrees of hyperglycemia with blood glucose level < 200 mg/dl, which can result in delayed diagnosis and treatment with potential for adverse metabolic consequences. Following the wide introduction of the sodium glucose transporter 2 inhibitors (SGLT2i) in therapeutic practice for DM type 2 treatment the amount of eu-DKA increased and therefore, interest to this entity rose. Read More

Pediatr Emerg Care 2019 Mar 22. Epub 2019 Mar 22.

Endocrinology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Objective: Management protocols for pediatric diabetic ketoacidosis (DKA) vary considerably among medical centers. The aim of this study was to investigate the efficacy and safety of 3 different fluid protocols in the management of DKA.

Methods: Fluid management protocols with sodium contents of 75, 100, and 154 mEq/L NaCl were compared. Read More

BMJ Open Diabetes Res Care 2019 13;7(1):e000591. Epub 2019 Feb 13.

Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

Objective: Insulin-dependent diabetes can occur with immune checkpoint inhibitor (ICI) therapy. We aimed to characterize the frequency, natural history and potential predictors of ICI-induced diabetes.

Research Design And Methods: We reviewed 1444 patients treated with ICIs over 6 years at our cancer center, and from the 1163 patients who received programmed cell death protein 1 (PD-1) inhibitors, we identified 21 such cases, 12 of which developed new-onset insulin-dependent diabetes and 9 experienced worsening of pre-existing type 2 diabetes. Read More

Cureus 2019 Jan 8;11(1):e3844. Epub 2019 Jan 8.

Pediatrics, University of Texas Health Science Center at Houston, Frisco, USA.

A 16-year-old female with new-onset diabetic ketoacidosis (DKA) developed acute pancreatitis and hypertriglyceridemia within 24 hours after admission. Her insulin regimen was continued after resolution of DKA, and her pancreatitis with hypertriglyceridemia showed resolution. We are presenting a case of pediatric DKA with hypertriglyceridemia and pancreatitis treated with extended insulin. Read More

World J Diabetes 2019 Mar;10(3):212-223

Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, United States.

Background: The prevalence of older individuals with type 2 diabetes mellitus (T2DM) is increasing due to the aging population and improved medical care. These patients are very susceptible to disease and treatment-related hospitalizations, resulting in higher health care costs, morbidity, and decreased quality of life. However, data of treatment-related complications, especially dysglycemia-related hospitalizations, are lacking. Read More

Int J Endocrinol 2019 12;2019:4784313. Epub 2019 Feb 12.

University Hospital "Dr. Jose E. Gonzalez, " Universidad Autonoma de Nuevo Leon, Endocrinology Division, Department of Internal Medicine, Monterrey 64460, Mexico.

Background: Hypertriglyceridemia and hyperglycemia coexist in 30-60% of patients with diabetes. The impact of hypertriglyceridemia regarding HbA1c assay reliability remains uncertain. Therefore, we conducted a prospective controlled study with the aim of defining the association between triglyceride levels and HbA1c. Read More

Eur J Hum Genet 2019 Mar 19. Epub 2019 Mar 19.

Clinical Research Unit, Khoo Teck Puat Hospital (KTPH), Singapore, Singapore.

A 22-year-old man was referred for continuation of diabetes mellitus treatment. He was first diagnosed with diabetes mellitus 2 months after birth, when he failed to thrive and showed symptoms of diabetic ketoacidosis. There was no family history of diabetes mellitus. Read More

Clin Obstet Gynecol 2019 Mar 13. Epub 2019 Mar 13.

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Medical University of South Carolina, Charleston, South Carolina.

Endocrine emergencies in pregnancy can be life threatening and are associated with increased morbidity for both the mother and fetus. Thyroid storm, diabetic ketoacidosis, and hypercalcemic crisis require a high clinical suspicion, rapid treatment, and multidisciplinary care to ensure best outcomes. Critical care consultation and intensive care unit admission are often warranted. Read More

Drug Des Devel Ther 2019 6;13:817-824. Epub 2019 Mar 6.

Association of Diabetes Investigators, Omaha, NE 68131, USA,

Gene knockout has been a powerful technique to evaluate the physiologic role of selected gene products. Lexicon pioneered high-throughput gene knockout technology and went further in designing agents to inhibit products of gene expression. Two agents have entered late-stage development. Read More

J Emerg Med 2019 Mar 14. Epub 2019 Mar 14.

Division of Emergency and Transport Medicine, Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California.

Background: Diabetic ketoacidosis (DKA) is a common complication affecting patients with type 1 diabetes, and DKA is associated with dehydration and electrolyte abnormalities. Supraventricular tachycardia (SVT), although a common tachydysrhythmia in the pediatric population, remains a rare entity in patients presenting with DKA.

Case Report: We describe a case of first-time SVT in an adolescent patient with DKA and recent methamphetamine abuse, with both factors likely predisposing him to develop a tachydysrhythmia. Read More

BMC Res Notes 2019 Mar 14;12(1):137. Epub 2019 Mar 14.

College of Medicine and Health Sciences, School of Nursing, Hawassa University, P.O.BOX: 1560, Hawassa, SNNPR, Ethiopia.

Objective: This study was aimed to assess the prevalence and associated factors of diabetic ketoacidosis among adult patients admitted in emergency department of Hawassa university comprehensive specialized hospital. An institution based retrospective cross-sectional study design was conducted among 195 adult patients aged 16 years and above with known or previously unknown diabetes cases presented in the emergency unit.

Result: In our study from the total 195 patients medical record reviewed 78 (40%) developed DKA. Read More

Pediatr Emerg Care 2019 03 12. Epub 2019 Mar 12.

Division of Pediatric Critical Care Medicine, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indiana University Health, Indianapolis, IN

Objectives: The majority of pediatric patients with diabetic ketoacidosis (DKA) present to community emergency departments (CEDs) that are less prepared to care for acutely ill children owing to low pediatric volume and limited pediatric resources and guidelines. This has impacted the quality of care provided to pediatric patients in CEDs. We hypothesized that a simulation-based collaborative program would improve the quality of the care provided to simulated pediatric DKA patients presenting to CEDs. Read More

J Med Biochem 2019 Apr 3;38(2):126-133. Epub 2019 Mar 3.

Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Background: We analyzed cardiovascular inflammatory (C-reactive protein (CRP), interleukin 6 (IL-6)), haemostatic (homocysteine) risk markers in lean and obese patients at admission and acute hyperglicemic crisis (AHC) resolving, involving diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS).

Methods: In that context, we included group A: N = 20 obese, B: N=20 lean patients with DKA; C: N = l0 obese, D: N=10 lean patients with HHS; E: N = 15 obese, F: N=15 lean controls. CRP IL-6, homocysteine were determined by ELISA. Read More

Autops Case Rep 2019 Jan-Mar;9(1):e2018072. Epub 2019 Jan 14.

Universidade de São Paulo (USP), Hospital Universitário, Surgery Division.São Paulo, SP,Brazil.

Endotracheal intubation injuries are rare, but may be devastating-mostly among the pediatric patients or when these occur in the distal trachea. Such complications typify a therapeutic challenge, which, besides requiring intellectual and technical resources, takes a long time to reach a resolution. The authors present the case of a 15-year-old girl admitted with an abnormal state of consciousness due to diabetic ketoacidosis. Read More

J Pediatr Endocrinol Metab 2019 Apr;32(4):335-340

Clinical Pathology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Background Thiamine deficiency is commonly reported in patients with diabetes especially during diabetic ketoacidosis (DKA) that could attribute to myocardial dysfunction in those patients. However, there is limited data regarding its relation to myocardial function among those patients. This study aimed to explore the association between myocardial function and serum thiamine levels in children with type 1 diabetes mellitus (DM). Read More

Diabetes Care 2019 Mar 12. Epub 2019 Mar 12.

Objective: This study examines the prevalence of disordered eating behaviors (DEB) and its associations with glycemic control, insulin sensitivity (IS), and psychosocial functioning in a large, diverse cohort of youth and young adults with type 1 or type 2 diabetes.

Research Design And Methods: In the SEARCH for Diabetes in Youth study, 2,156 youth and young adults with type 1 diabetes (mean ± SD age 17.7 ± 4. Read More

J Forensic Leg Med 2019 Apr 26;63:34-39. Epub 2019 Feb 26.

Institute of Forensic Medicine, University of Southern Denmark, J.B. Winsløws Vej 17B, 5000, Odense C, Denmark. Electronic address:

Purpose: To report a case in which autopsy findings and data from an insulin pump illustrate the course up to the death of a 31-year-old man with a history of type 1 diabetes mellitus who was found dead in his apartment with his insulin pump disassembled and placed in another room.

Methods: Autopsy findings including histological, toxicological and biochemical examination are presented. Postmortem download of data from the insulin pump gave the history of the pump, which included blood glucose, insulin bolus, carbohydrate intake and the time course in the days to death, and the pump settings were recorded. Read More

Crit Care Med 2019 May;47(5):700-705

Department of Pharmacy Services, University of California Davis Medical Center, Sacramento, CA.

Objectives: Insulin infusion therapy is commonly used in the hospital setting to manage diabetic ketoacidosis and hyperosmolar hyperglycemic state. Clinical evidence suggests both hypoglycemia and glycemic variability negatively impact patient outcomes. The hypothesis of this study was that moderate-intensity insulin therapy decreases hospital length of stay and prevalence of hypoglycemia in patients with diabetic ketoacidosis and hyperosmolar hyperglycemic state. Read More

Curr Oncol 2019 Feb 1;26(1):e115-e118. Epub 2019 Feb 1.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Japan.

Nivolumab, an anti-PD-1 antibody, is now considered an important therapeutic agent in several advanced malignancies. However, immune-related adverse events such as endocrinopathies have been reported with its use. Thyroid disorder and isolated adrenocorticotropic hormone deficiency have frequently been reported as nivolumab-induced immune-related adverse events. Read More