3,334 results match your criteria Diabetic Foot Infections


Microbiological and antimicrobial pattern of diabetic foot ulcers (DFUs) at a tertiary care center in North East, Punjab.

J Pak Med Assoc 2021 Jun;71(6):1566-1569

Department of Microbiology, The Kidney Centre, Post Graduate Training Institute Karachi, Pakistan.

Objective: To determine the pattern of antimicrobial sensitivity of common microorganisms isolated from diabetic foot infections.

Methods: The cross-sectional study was conducted from January to August 2019 at the Diabetes and Footcare Clinic, Mayo Hospital, Lahore, Pakistan, and comprised deep-seated tissue samples from the ulcer bed that were tested for culture and sensitivity. Antimicrobial susceptibility was determined in accordance with Clinical and Laboratory Standards Institute guidelines. Read More

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Does metabolic control have any influence on the clinical presentation and short-term outcomes of diabetic foot infections?

Adv Wound Care (New Rochelle) 2021 Jun 3. Epub 2021 Jun 3.

Costa Rican Social Security, 42697, Diabetic Foot Unit, San Jose, Costa Rica;

Objective We hypothesized that patients with poor glycemic control undergoing treatment for diabetic foot infections (DFIs) would have a poorer prognosis than those with better metabolic control assessed by glycated hemoglobin (HbA1c). Approach We analyzed a retrospective cohort of 245 patients with moderate and severe DFIs. HbA1c values were dichotomized (<7% or ≥7% and 75th percentile (P75) and >P75) to analyze patient outcomes regarding metabolic control. Read More

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The Influence of Multidrug-Resistant Bacteria on Clinical Outcomes of Diabetic Foot Ulcers: A Systematic Review.

J Clin Med 2021 May 1;10(9). Epub 2021 May 1.

Diabetic Foot Unit, Clínica Universitaria de Podología, Facultad de Enfermería, Fisioterapia y Podología, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.

Multidrug-resistant organism infections have become important in recent years due to the increased prevalence of diabetic foot ulcers and their possible consequences. This study aimed to systematically review and evaluate ulcer duration, healing time, hospital stay, amputation, and mortality rates in patients with diabetic foot ulcers caused by infection with multidrug-resistant organisms. PubMed, the Cochrane Library, and Web of Science were searched in May 2020 to find observational studies in English about the clinical outcomes of multidrug-resistant organism infection in diabetic foot ulcers. Read More

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Synergistic bactericidal activities of tobramycin with ciprofloxacin and azithromycin against Klebsiella pneumoniae.

J Antibiot (Tokyo) 2021 May 28. Epub 2021 May 28.

State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, 300071, China.

Trans-translation is a unique bacterial ribosome rescue system that plays important roles in the tolerance to environmental stresses. It is composed of an ssrA-encoded tmRNA and a protein SmpB. In this study, we examined the role of trans-translation in antibiotic tolerance in Klebsiella pneumoniae and explored whether the inhibition of this mechanism could enhance the bactericidal activities of antibiotics. Read More

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Osteomyelitis infection caused by in a diabetic patient: A first case report.

IDCases 2021 26;24:e01139. Epub 2021 Apr 26.

Genetics Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.

can cause deep infections, including osteomyelitis. In this study, an automated system misidentified this causal agent as species but 16 s rRNA sequencing correctly identified it as . Recognizing the capability of to establish the disease is of great importance to enable accurate diagnosis and begin the suitable antibiotic therapy. Read More

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Recurrent cellulitis caused by an occult foreign body in a diabetic foot.

BMJ Case Rep 2021 May 19;14(5). Epub 2021 May 19.

Department of Trauma and Orthopaedic Surgery, Beaumont Hospital, Dublin, Ireland.

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Observation of the effect of one-to-one education on high-risk cases of diabetic foot.

World J Clin Cases 2021 May;9(14):3265-3272

Department of Endocrinology and Metabolism, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510630, Guangdong Province, China.

Background: Diabetes is a common chronic disease, and its global incidence is on the rise. The disease is directly attributed to insufficient insulin efficacy/secretion, and patients are often accompanied by multiple complications. Diabetic foot is one of the most common complications of diabetes. Read More

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Recent advances in the induced pluripotent stem cell-based skin regeneration.

Wound Repair Regen 2021 May 10. Epub 2021 May 10.

Department of Applied Biology, Council of Scientific & Industrial Research-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, India.

Skin regeneration has been a challenging clinical problem especially in cases of chronic wounds such as diabetic foot ulcers, and epidermolysis bullosa-related skin blisters. Prolonged non-healing wounds often lead to bacterial infections increasing the severity of wounds. Current treatment strategies for chronic wounds include debridement of wounds along with antibiotics, growth factors, and stem cell transplantation therapies. Read More

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Acute Fixation of Displaced Intra-articular Calcaneus Fractures Is Safe Using the Sinus Tarsi Approach.

J Orthop Trauma 2021 06;35(6):289-295

Department of Orthopaedic Surgery, Case Western Reserve University School of Medicine, Cleveland, OH.

Objective: To analyze the correlation between surgical timing and outcomes for calcaneus fractures treated using a sinus tarsi approach (STA).

Setting: Single Level-1 trauma center.

Design: Retrospective. Read More

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Staphylococcus aureus clones causing osteomyelitis; a literature review (2000-2020).

J Glob Antimicrob Resist 2021 May 6. Epub 2021 May 6.

Department of Infectious Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

Objectives: Staphylococcus aureus is the most common causative organism of osteomyelitis (OM). Nevertheless, the molecular epidemiology of S. aureus causing OM remains ill-defined. Read More

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Virtual triage and outcomes of diabetic foot complications during Covid-19 pandemic: A retro-prospective, observational cohort study.

PLoS One 2021 6;16(5):e0251143. Epub 2021 May 6.

Tameside and Glossop Integrated Care NHS Foundation Trust, Tameside on Lyne, United Kingdom and Manchester Metropolitan University, Manchester, United Kingdom.

Aims: Limb and patient outcomes in people with diabetic foot complications including diabetic foot ulcer (DFU) provided virtual triage and personalized video consultations during COVID-19 pandemic are not known.

Methods: Patients with foot complications attending the diabetic foot clinic prior to lockdown who sought teleconsultations during COVID-19 lockdown underwent virtual triage to include clinical history, visual inspection of feet, domiciliary wound care (community nurse assisted dressings) and offloading instructions. The subsequent ulcer, limb and mortality outcomes during the following 24 weeks of COVID-19 lockdown (April-September 2020, group 1) were assessed and compared with those who attended foot clinic during the same period in 2019 (April-September, group 2). Read More

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Pasteurella Multocida Bacteremia and Septic Arthritis in a Patient With Non-Bite Animal Exposure.

Cureus 2021 Mar 28;13(3):e14162. Epub 2021 Mar 28.

Internal Medicine Residency, Kettering Medical Center, Dayton, USA.

() is a gram-negative, facultative anaerobe, and it is most commonly found in the oropharynx of healthy domestic animals, especially cats and dogs.  is classified as an opportunistic pathogen, infecting individuals only through direct contact via local trauma caused by animal bites or scratches. More serious infections, while rare, are typically associated with immunocompromised states, known pre-existing cavitary lung pathology, or malignancy. Read More

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Topical Application of Ozonated Oils for the Treatment of MRSA Skin Infection in an Animal Model of Infected Ulcer.

Biology (Basel) 2021 Apr 26;10(5). Epub 2021 Apr 26.

Microbiology and Antibiotic Resistance Team (MicroART), Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal.

Diabetic foot ulcers are a common cause of morbidity in diabetic patients. One of the main pathogens found in these ulcers is methicillin-resistant (MRSA). MRSA often carries resistance to several classes of antibiotics and their infections are becoming harder to treat. Read More

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Harnessing Digital Health Technologies to Remotely Manage Diabetic Foot Syndrome: A Narrative Review.

Medicina (Kaunas) 2021 Apr 14;57(4). Epub 2021 Apr 14.

Interdisciplinary Consortium on Advanced Motion Performance (iCAMP), Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.

About 422 million people worldwide have diabetes and approximately one-third of them have a major risk factor for diabetic foot ulcers, including poor sensation in their feet from peripheral neuropathy and/or poor perfusion to their feet from peripheral artery disease. The current healthcare ecosystem, which is centered on the treatment of established foot disease, often fails to adequately control key reversible risk factors to prevent diabetic foot ulcers leading to unacceptable high foot disease amputation rate, 40% recurrence of ulcers rate in the first year, and high hospital admissions. Thus, the latest diabetic foot ulcer guidelines emphasize that a paradigm shift in research priority from siloed hospital treatments to innovative integrated community prevention is now critical to address the high diabetic foot ulcer burden. Read More

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Treating Diabetic Foot Osteomyelitis: A Practical State-of-the-Art Update.

Medicina (Kaunas) 2021 Apr 1;57(4). Epub 2021 Apr 1.

Department of Orthopedic Surgery, Balgrist University Hospital, University of Zurich, 8008 Zurich, Switzerland.

Diabetic foot osteomyelitis (DFO) can be difficult to treat and securing optimal clinical outcomes requires a multidisciplinary approach involving a wide variety of medical, surgical and other health care professionals, as well as the patient. Results of studies conducted in the past few years have allowed experts to formulate guidelines that can improve clinical outcomes. We conducted a narrative review of the literature on treat- ment of DFO, with an emphasis on studies published in the last two years, especially regarding antimicrobial therapies and surgical approached to treatment of DFO, supplemented by our own extensive clinical and research experience in this field. Read More

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Comparative Evaluation of the Diagnostic Value of Procalcitonin and hsCRP for the Presence of Mild-to-Moderate Diabetic Foot Infections.

Int J Low Extrem Wounds 2021 Apr 28:15347346211011849. Epub 2021 Apr 28.

159238Medical University of Sofia, Sofia, Bulgaria.

The aim of this study is to compare the efficacy of procalcitonin (PCT) and high-sensitive C-reactive protein (hsCRP) as diagnostic biomarkers in patients with diabetes and mild-to-moderate diabetic foot infections. A total of 119 patients (102 with type 2 diabetes and 17 with type 1 diabetes), of mean age 60.29 ± 10. Read More

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Bacterial Profile and Antimicrobial Resistance Patterns of Infected Diabetic Foot Ulcers in Iran: A Systematic Review and Meta-Analysis of Cross-Sectional Studies.

Int J Low Extrem Wounds 2021 Apr 28:15347346211002715. Epub 2021 Apr 28.

Isfahan Endocrine and Metabolism Research Center, 48455Isfahan University of Medical Sciences, Isfahan, Iran.

Since infectious foot ulcers represent one of the major causes of lower-limb amputation, it calls for an appropriate action for early detection and sufficient treatment of diabetic foot infection (DFI). The present study aimed at investigating the bacterial epidemiology and antimicrobial resistance (AMR) patterns of DFIs in Iran. We have conducted a systematic search in PubMed, Embase, Web of Science, Scopus, Google Scholar, and Scientific Information Database to identify all articles reporting the proportion of different kinds of bacteria isolated from Iranian DFI samples. Read More

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Long-term Mortality of a Cohort of Patients Undergoing Surgical Treatment for Diabetic Foot Infections. An 8-year Follow-up Study.

Int J Low Extrem Wounds 2021 Apr 28:15347346211009425. Epub 2021 Apr 28.

118003San Juan de Dios Hospital, San José, Costa Rica.

We analyzed a retrospective cohort of 150 patients with diabetic foot infections (DFIs) who underwent surgical treatment to determine long-term outcomes. The median follow-up of the series was 7.6 years. Read More

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Microbial profile, antimicrobial resistance, and molecular characterization of diabetic foot infections in a university hospital.

Germs 2021 Mar 15;11(1):39-51. Epub 2021 Mar 15.

MD, Internal Medicine Department (Unit of Diabetes & Metabolism), Faculty of Medicine, Alexandria University, 21512, Egypt.

Introduction: Diabetic foot infections (DFIs) are among the most severe complications of diabetes. The aim of this study was to determine the etiological pathogens of DFIs in different Wagner's and IDSA/IWGDF grades, and to assess their antimicrobial susceptibility pattern together with molecular characterization of antibiotic resistance genes.

Methods: A prospective study was conducted on 120 DFI patients at Main Alexandria University Hospital, Egypt. Read More

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Biofilm-Innate Immune Interface: Contribution to Chronic Wound Formation.

Front Immunol 2021 9;12:648554. Epub 2021 Apr 9.

Department of Health Sciences, Carleton University, Ottawa, ON, Canada.

Delayed wound healing can cause significant issues for immobile and ageing individuals as well as those living with co-morbid conditions such as diabetes, cardiovascular disease, and cancer. These delays increase a patient's risk for infection and, in severe cases, can result in the formation of chronic, non-healing ulcers (e.g. Read More

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Onychomycosis and Tinea Pedis in the Feet of Patients With Diabetes.

Int J Low Extrem Wounds 2021 Apr 23:15347346211009409. Epub 2021 Apr 23.

118003San Jorge Hospital, Huesca, Spain.

This study aimed to determine the prevalence of onychomycosis and interdigital tinea pedis in a cohort of Spanish patients with diabetes in whom onychomycosis was clinically suspected (n = 101). Samples from a first toenail scraping and the fourth toe clefts were subjected to potassium hydroxide direct vision and incubated in Sabouraud and dermatophyte test medium. Fifty-eight samples were also analyzed by a pathologist using periodic acid-Schiff staining and Calcofluor white direct fluorescence microscopy. Read More

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Conservative Surgery for Diabetic Foot Osteomyelitis is not Associated With Longer Survival Time Without Recurrence of Foot Ulcer When Compared With Amputation.

Int J Low Extrem Wounds 2021 Apr 23:15347346211009403. Epub 2021 Apr 23.

118003San Juan de Dios Hospital, San José, Costa Rica.

Conservative surgery of diabetic foot osteomyelitis (DFO) in which bone infection is removed without amputation could minimize the biomechanical changes associated with foot surgery. We hypothesize that patients who undergo conservative surgery will have a longer survival time without recurrence of foot ulcers and further amputations than those who undergo any type of amputation to treat DFO. We assessed a retrospective cohort of 108 patients who underwent surgery for DFO from January 2011 to December 2012. Read More

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How good are clinicians in predicting the presence of spp. in diabetic foot infections? A prospective clinical evaluation.

Endocrinol Diabetes Metab 2021 04 9;4(2):e00225. Epub 2021 Feb 9.

Department of Orthopedic Surgery Balgrist University Hospital Zurich Switzerland.

Introduction: The most frequently prescribed empirical antibiotic agents for mild and moderate diabetic foot infections (DFIs) are amino-penicillins and second-generation cephalosporins that do not cover spp. Many clinicians believe they can predict the involvement of in a DFI by visual and/or olfactory clues, but no data support this assertion.

Methods: In this prospective observational study, we separately asked 13 experienced (median 11 years) healthcare workers whether they thought the spp. Read More

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Microbiological Concordance in the Management of Diabetic Foot Ulcer Infections with Osteomyelitis, on the Basis of Cultures of Different Specimens at a Diabetic Foot Center in China.

Diabetes Metab Syndr Obes 2021 6;14:1493-1503. Epub 2021 Apr 6.

Department of Critical Care Medicine, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Hubei, People's Republic of China.

Objective: This study aimed to assess the microbiological concordance between swab and soft tissue cultures, and corresponding bone specimen cultures from patients with diabetic foot osteomyelitis (DFO). We aimed to analyze the bone specimens' antimicrobial susceptibilities, and to improve clinical management of diabetic foot ulcer infections by using proper antibiotics.

Methods: The microbial culture results of ulcer swabs, and soft tissue and bone tissue specimens, and the antimicrobial susceptibility tests of bone specimens from patients with DFO were analyzed in a single diabetic foot center. Read More

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Diabetic Foot Amputation Prevention During COVID-19.

Adv Skin Wound Care 2021 May;34(5):1-4

Kshitij Shankhdhar, MBBS, MD, PhD, is Diabetologist, L.K. Diabetes Centre, Indira Nagar, Lucknow, India. The author has disclosed no financial relationships related to this article. Submitted October 15, 2020; accepted in revised form December 4, 2020.

Abstract: In this case report, the treatment of a patient with a diabetic foot ulcer on his left foot was interrupted by the novel coronavirus 2019 pandemic lockdown in India. The author guided the patient via telephone and online services. Based on the history given by the patient, the lesion started as blistering from improperly fitted footwear that then evolved into multiple infected ulcerations on the dorsal surface of the great toe (osteomyelitis with septic arthritis of the joint). Read More

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Antibiotic resistance in diabetic foot infection: how it changed with COVID-19 pandemic in a tertiary care center.

Diabetes Res Clin Pract 2021 Apr 15;175:108797. Epub 2021 Apr 15.

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy; Unit of Diabetes, University of Campania "Luigi Vanvitelli", Naples, Italy. Electronic address:

Aim: To investigate the rate of antibiotic resistance and its main risk factors in a population of patients with diabetic foot infection (DFI) during the COVID-19 pandemic, in comparison with the population of 2019.

Methods: Two hundred and twenty-five patients with DFI were admitted in a tertiary care center from January 2019 to December 2020. Antibiotic resistance was evaluated by microbiological examination of soft tissues' or bone's biopsy. Read More

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In vitro activity of dalbavancin against Gram-positive bacteria isolated from diabetic foot osteomyelitis.

J Antimicrob Chemother 2021 Apr 11. Epub 2021 Apr 11.

Virulence Bactérienne et Infections Chroniques, INSERM U1047, Université de Montpellier, Service de Microbiologie et Hygiène Hospitalière, Clinique du Pied Diabétique Gard Occitanie, CHU Nîmes, Nîmes, France.

Background: Diabetic foot infections (DFIs) represent a serious threat to public health because of their frequency and the severity of their consequences, i.e. osteomyelitis and amputation. Read More

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Travel-related control measures to contain the COVID-19 pandemic: an evidence map.

BMJ Open 2021 04 9;11(4):e041619. Epub 2021 Apr 9.

Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilians University Munich, Munich, Germany.

Objectives: To comprehensively map the existing evidence assessing the impact of travel-related control measures for containment of the SARS-CoV-2/COVID-19 pandemic.

Design: Rapid evidence map.

Data Sources: MEDLINE, Embase and Web of Science, and COVID-19 specific databases offered by the US Centers for Disease Control and Prevention and the WHO. Read More

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The global state of research and trends in osteomyelitis from 2010 to 2019: a 10-year bibliometric analysis.

Ann Palliat Med 2021 Apr 24;10(4):3726-3738. Epub 2021 Feb 24.

Department of Orthopaedics, Fuzhou Second Hospital Affiliated to Xiamen University, Teaching Hospital of Fujian Medical University, Fuzhou, China; Trauma Medical Center of Fuzhou City, Fuzhou Second Hospital Affiliated to Xiamen University, Fuzhou, China.

Background: Osteomyelitis is a difficult problem for orthopedic surgeons due to its great harm and complicated treatment. In this study, we aim to make a bibliometric analysis of the literature related to osteomyelitis and explore the research status, hotspots and frontiers in this field in recent 10 years.

Methods: Literature relating to osteomyelitis from 2010 to 2019 was retrieved from the database of Science Citation Index Expanded (SCIE) of Web of Science. Read More

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A Comparative Analysis of Antibiotic Usage in Diabetic Foot Infections Against Healing Time.

J Foot Ankle Surg 2021 Mar 13. Epub 2021 Mar 13.

Department of Clinical Nursing, Medical University of Warsaw, Warsaw, Poland.

The study aimed to analyze bacterial flora in diabetic foot infection, empiric and targeted antibiotic therapy, and factors influencing wound healing duration. The study we undertook a review analysis of data in 118 cases of diabetic foot among 98 patients who reported to the Wound Care Clinic in Warsaw, Poland between 01/2014 and 12/2018. Collected data included sociodemographic data, wounds information, used treatment, results of the microbiological examination, and empiric and targeted antibiotic therapy. Read More

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