3,787 results match your criteria Diabetic Foot Infections


Wound Coverage Options for Soft Tissue Defects Following Calcaneal Fracture Management (Operative/Surgical).

Clin Podiatr Med Surg 2019 Apr 12;36(2):323-337. Epub 2018 Dec 12.

Plastic Reconstructive and Orthopaedic Surgery, University of Pennsylvania Health System, Perelman Center for Advanced Medicine, 3400 Civic Center Boulevard, South Pavilion, 1st Floor, Philadelphia, PA 19104, USA.

Soft tissue defects and wound healing complications related to calcaneus fractures may result in significant morbidity. The management of these soft tissue complications requires following reconstructive principles that provide the requisites for preservation of the injured limb and the maximization of function. Soft tissue complications are addressed with methods that commensurate with the degree of injury, ranging from local wound care to free flap reconstruction. Read More

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http://dx.doi.org/10.1016/j.cpm.2018.10.012DOI Listing

A meta-analysis of the relationship between foot local characteristics and major lower extremity amputation in diabetic foot patients.

J Cell Biochem 2019 Feb 19. Epub 2019 Feb 19.

Department of Peripheral Vascular, Beijing University of Chinese Medicine, Dongzhimen Hospital, Beijing, China.

Objective: To clarify and quantify risk factors among local characteristics of the foot for major amputation in diabetic foot patients.

Methods: Articles published before January 2018 on PubMed and Embase were conducted observational studies about risk factors for major amputation in patients with diabetic foot were retrieved and systematically reviewed by using Stata 12.0 statistical software. Read More

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http://doi.wiley.com/10.1002/jcb.28183
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http://dx.doi.org/10.1002/jcb.28183DOI Listing
February 2019
1 Read

Ankle fusion following failed initial treatment of complex ankle fractures in neuropathic diabetics.

Foot Ankle Surg 2019 Feb 5. Epub 2019 Feb 5.

The Department of Orthopaedic Surgery and Rehabilitation, Loyola University Health System, 2160 South First Avenue, Maywood, IL 60153, United States. Electronic address:

Background: Unstable ankle fractures in diabetics with peripheral neuropathy have an increased risk of postoperative complications, often leading to amputation. Primary ankle arthrodesis has been suggested as an alternative when acceptable reduction and mechanical stabilization cannot be obtained.

Methods: Over a fourteen year period, thirteen diabetic patients with peripheral neuropathy underwent an attempt at primary ankle arthrodesis following the early post-fracture development of acute neuropathic (Charcot) deformity of the ankle after sustaining a low energy unstable ankle fracture. Read More

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http://dx.doi.org/10.1016/j.fas.2019.01.010DOI Listing
February 2019
1 Read

Review on Wearables to Monitor Foot Temperature in Diabetic Patients.

Sensors (Basel) 2019 Feb 14;19(4). Epub 2019 Feb 14.

Department of Nursing, University of Extremadura, E06006 Badajoz, Spain.

One of the diseases that could affect diabetic patients is the diabetic foot problem. Unnoticed minor injuries and subsequent infection can lead to ischemic ulceration, and may end in a foot amputation. Preliminary studies have shown that there is a positive relationship between increased skin temperature and the pre⁻ulceration phase. Read More

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http://www.mdpi.com/1424-8220/19/4/776
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http://dx.doi.org/10.3390/s19040776DOI Listing
February 2019
2 Reads

Treatment of diabetic foot wounds with acellular fish skin graft rich in omega-3: a prospective evaluation.

J Wound Care 2019 Feb;28(2):76-80

Consultant Vascular Surgeon; Department of Vascular Surgery, Royal Cornwall Hospital, UK.

Objective:: To evaluate the potential benefit of an intact fish skin graft rich in omega-3 (Kerecis Omega3), in the management of postoperative diabetic foot wounds.

Method:: Prospective evaluation in eight patients with diabetes following forefoot surgery. The dressing was applied weekly for a period of six weeks in the diabetic foot clinic. Read More

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http://dx.doi.org/10.12968/jowc.2019.28.2.76DOI Listing
February 2019
1 Read

Hard-to-heal diabetic foot ulcers treated using negatively charged polystyrene microspheres: a prospective case series.

J Wound Care 2019 Feb;28(2):104-109

Diabetic Foot Unit, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.

Objective:: To describe the outcomes of a new product based on negatively charged polystyrene microspheres (NCM) technology, in non-responding diabetic foot ulcers (DFU).

Methods:: A clinical case series of patients with a hard-to-heal DFU treated with NCM were recruited between March and June 2017 in a specialised diabetic foot unit. DFUs were treated daily with NCM over four weeks, although the health professional could decide to continue NCM treatment in some patients. Read More

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http://www.magonlinelibrary.com/doi/10.12968/jowc.2019.28.2.
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http://dx.doi.org/10.12968/jowc.2019.28.2.104DOI Listing
February 2019
2 Reads

Pentraxin-3: A new parameter in predicting the severity of diabetic foot infection?

Int Wound J 2019 Feb 15. Epub 2019 Feb 15.

Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Firat University, Elazig, Turkey.

This study was undertaken to evaluate the diagnostic and prognostic values of pentraxin-3 (PTX-3) in patients with infected diabetic foot ulcers (IDFU) as well as to assess the association between PTX-3 levels and IDFU severity. This study included 60 IDFU patients (Group 1), 45 diabetic patients without DFU (Group 2), and 45 healthy controls. Patients with IDFU were divided into mild, moderate, and severe subgroups based on classification of clinical severity. Read More

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http://dx.doi.org/10.1111/iwj.13075DOI Listing
February 2019
2 Reads

Development of Charcot Neuroarthropathy in Diabetic Patients who Received Kidney or Kidney-Pancreas Transplants.

J Foot Ankle Surg 2019 Feb 11. Epub 2019 Feb 11.

Assistant Professor, Podiatric Medicine and Surgery Residency Program, The Ohio State University Wexner Medical Center, Columbus, OH.

Only a small percentage of the general diabetic population develops Charcot neuroarthropathy. Charcot arthropathy greatly increases the risk of foot complications. At our academic institution, there appeared to be an increased incidence of Charcot arthropathy in transplant patients. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.09.022DOI Listing
February 2019
1 Read

A neglected causative agent in diabetic foot infection: a retrospective evaluation of 13 patients with fungal etiology

Turk J Med Sci 2019 Feb 11;49(1):81-86. Epub 2019 Feb 11.

Background/aim: Clinicians often neglect fungal infections and do not routinely investigate deep tissue from the wound for fungal culture and sensitivity due to insufficient information in the literature. In this study, we aimed to evaluate fungal etiology of invasive fungal diabetic foot which is rarely reported in the literature.

Materials And Methods: The patients who were unresponsive to antibiotic therapy and those with positive fungal in bone or deep tissue culture were enrolled in the study. Read More

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http://dx.doi.org/10.3906/sag-1809-74DOI Listing
February 2019
1 Read

Methicillin-Resistant Staphylococcus aureus Endocarditis from a Diabetic Foot Ulcer .

J Am Podiatr Med Assoc 2018 Nov;108(6):528-531

Diabetic foot infections are a common cause of morbidity and mortality in the United States, and successful treatment often requires an aggressive and prolonged approach. Recent work has elucidated the importance of appropriate therapy for a given severity of diabetic foot infection, and highlighted the ongoing risk such patients have for subsequent invasive life-threatening infection should diabetic foot ulcers fail to heal. The authors describe the case of a man with diabetes who had prolonged, delayed healing of a diabetic foot ulcer. Read More

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http://www.japmaonline.org/doi/10.7547/17-139
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http://dx.doi.org/10.7547/17-139DOI Listing
November 2018
2 Reads

Safety of SGLT2 Inhibitors in Patients with Diabetes Mellitus.

Curr Drug Saf 2019 Feb 6. Epub 2019 Feb 6.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER-Raebareli), Lucknow (UP). India.

Background: Recently, Food and Drug Administration (FDA) has approved sodium/glucose co-transporter 2 (SGLT2) inhibitors for the treatment of diabetes mellitus. However, regarding adverse drug reactions (ADRs) of SGLT2 inhibitors in large group of population, very less information is available. Thus, we have tried to find out the risk profile of SGLT 2 inhibitors. Read More

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http://dx.doi.org/10.2174/1574886314666190206164647DOI Listing
February 2019
1 Read

Risk factor analysis on the healing time and infection rate of diabetic foot ulcers in a referral wound care clinic.

J Wound Care 2019 Jan;28(Sup1):S4-S13

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

Objective:: Objectives. To determine the prevalence and risk factors for diabetic foot infection (DFI), and to identify factors associated with delayed wound healing of diabetic foot ulcer (DFU).

Method:: The retrospective study was performed in a referral wound care clinic in Hospital Kuala Lumpur. Read More

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http://dx.doi.org/10.12968/jowc.2019.28.Sup1.S4DOI Listing
January 2019
3 Reads

The use of bioactive glass S53P4 in the treatment of an infected Charcot foot: a case report.

J Wound Care 2019 Jan;28(Sup1):S14-S17

Southwestern Academic Limb Salvage Alliance (SALSA), Department of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA, US.

Objective:: To report a case of successful limb-salvage staged treatment in the treatment of an infected diabetic Charcot foot.

Case Summary:: A 45-year-old male with long-term, uncontrolled type 2 diabetes, six months' history of progressive deformity on the right foot and 45 days of purulent drainage in the lateral aspect of the foot. Patient was diagnosed with an infected Charcot foot with extensive midfoot bone involvement as shown by radiographic and MRI images. Read More

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http://dx.doi.org/10.12968/jowc.2019.28.Sup1.S14DOI Listing
January 2019
2 Reads

Oral Amoxicillin/Clavulanate for Treating Diabetic Foot Infections.

Diabetes Obes Metab 2019 Feb 5. Epub 2019 Feb 5.

Service of Infectious Diseases, Geneva University Hospitals, Geneva.

Some clinicians avoid amoxicillin-clavulanate (AMC) for the oral therapy of diabetic foot infections (DFI), especially for osteomyelitis (DFO), due to its poor bioavailability and bone penetration of all antibiotics from the β-lactam class. We performed a retrospective cohort analysis among 794 DFI episodes, including 339 DFO cases. The median duration of antibiotic therapy after surgical debridement (including partial amputation) was 30 days (DFO 30 days). Read More

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http://dx.doi.org/10.1111/dom.13651DOI Listing
February 2019
7 Reads
6.360 Impact Factor

Discordant isolates in bone specimens from patients with recurrent foot osteomyelitis.

Eur J Clin Microbiol Infect Dis 2019 Feb 5. Epub 2019 Feb 5.

Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard (OCL 112), Houston, TX, 77030, USA.

We compared paired operative bone cultures (initial operation and reoperation) for 35 patients who experienced foot osteomyelitis treatment failure at a single hospital. Concordance was poor (kappa = 0.180). Read More

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http://dx.doi.org/10.1007/s10096-019-03470-wDOI Listing
February 2019
1 Read

Disparities in outcomes of patients admitted with diabetic foot infections.

PLoS One 2019 4;14(2):e0211481. Epub 2019 Feb 4.

Southwest Academic Limb Salvage Alliance (SALSA), Los Angeles, CA, United States of America.

Objective: The purpose of this study was to evaluate the disparities in the outcomes of White, African American (AA) and non-AA minority (Hispanics and Native Americans (NA)), patients admitted in the hospitals with diabetic foot infections (DFIs).

Research Design And Methods: The HCUP-Nationwide Inpatient Sample (2002 to 2015) was queried to identify patients who were admitted to the hospital for management of DFI using ICD-9 codes. Outcomes evaluated included minor and major amputations, open or endovascular revascularization, and hospital length of stay (LOS). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211481PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361439PMC
February 2019
1 Read

The effects of magnesium and vitamin E co-supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.

Wound Repair Regen 2019 Jan 28. Epub 2019 Jan 28.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

This study was carried out to determine the effects of magnesium and vitamin E co-supplementation on wound healing and metabolic status in patients with diabetic foot ulcer (DFU). The current randomized, double-blind, placebo-controlled trial was conducted among 57 patients with grade 3 DFU. Participants were randomly divided into two groups to take either 250 mg magnesium oxide plus 400 IU vitamin E (n = 29) or placebo per day (n = 28) for 12 weeks. Read More

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http://dx.doi.org/10.1111/wrr.12701DOI Listing
January 2019
1 Read

Screening and preliminary validation of T lymphocyte immunoregulation‑associated long non‑coding RNAs in diabetic foot ulcers.

Mol Med Rep 2019 Mar 17;19(3):2368-2376. Epub 2019 Jan 17.

Department of Surgery, Yijishan Hospital, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.

The present study aimed to investigate the existence of immunoregulation‑associated long non‑coding (lnc)RNAs mediated by T lymphocytes in the wound surfaces of diabetic foot ulcers (DFUs). The wound skin tissues of patients receiving debridement for trauma or DFUs associated with infection were obtained. Dermatological histological changes were observed by pathological staining, and T lymphocyte subsets and inflammation‑associated cytokines were identified. Read More

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http://dx.doi.org/10.3892/mmr.2019.9877DOI Listing
March 2019
3 Reads

Principles and practice of antibiotic stewardship in the management of diabetic foot infections.

Curr Opin Infect Dis 2019 Jan 16. Epub 2019 Jan 16.

University of Washington, Seattle, USA.

Purpose Of Review: Systemic antibiotic therapy in persons with a diabetic foot infection (DFI) is frequent, increasing the risk of promoting resistance to common pathogens. Applying principles of antibiotic stewardship may help avoid this problem.

Recent Findings: We performed a systematic review of the literature, especially seeking recently published studies, for data on the role and value of antibiotic stewardship (especially reducing the spectrum and duration of antibiotic therapy) in community and hospital populations of persons with a DFI. Read More

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http://dx.doi.org/10.1097/QCO.0000000000000530DOI Listing
January 2019
5 Reads
5.006 Impact Factor

A Bibliometric Analysis of Global Research Production Pertaining to Diabetic Foot Ulcers in the Past Ten Years.

J Foot Ankle Surg 2019 Jan 15. Epub 2019 Jan 15.

Professor, School of Nursing, Nantong University, Nantong, Jiangsu, People's Republic of China. Electronic address:

The aim of this study was to demonstrate the state of diabetic foot ulcer (DFU) research in the past 10 years by bibliometric analysis, especially by performing document co-citation and co-word visualization analysis to reveal the research hotspots, frontiers, and core literature. The literature in connection with DFUs from 2007 to 2018 was retrieved from the Web of Science Core Collection database (WoSCC). We used the WoSCC and CiteSpace to analyze publication outcomes, journals, research direction, research hotspots, and frontiers. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.08.052DOI Listing
January 2019
3 Reads

Five-year Audit of Infectious Diseases at a Tertiary Care Hospital in Karachi, Pakistan.

Cureus 2018 Nov 5;10(11):e3551. Epub 2018 Nov 5.

Miscellaneous, The Indus Hospital, Karachi, PAK.

Purpose To estimate the burden of infectious diseases and the seasonality of mosquito-borne diseases seen at The Indus Hospital, Karachi (TIH). Methodology We performed a retrospective data analysis of all infectious diseases (ID) cases, retrieved from medical records over a five-year period starting from 1 January 2012 till 31 December 2016 at The Indus Hospital (TIH), which is a 150-bed, charity-based, tertiary-care health facility. The collected data has been categorized into three groups: (A) public health-related diseases, including community and environmental IDs, i. Read More

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http://dx.doi.org/10.7759/cureus.3551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324853PMC
November 2018
2 Reads

[Effectiveness of transverse tibial bone transport in treatment of diabetic foot ulcer].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Jan;33(1):23-27

Department of Orthopedics, Xiasha Campus, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou Zhejiang, 310018, P.R.China.

Objective: To evaluate the effectiveness of transverse tibial bone transport in treatment of diabetic foot ulcer.

Methods: Between June 2014 and December 2017, 17 patients with diabetic foot ulcer were treated. There were 11 males and 6 females, with a median age of 57 years (range, 46-72 years). Read More

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http://dx.doi.org/10.7507/1002-1892.201807143DOI Listing
January 2019
3 Reads

Efficacy of comprehensive ozone therapy in diabetic foot ulcer healing.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):822-825. Epub 2018 Dec 1.

Health Research Center, Baitullah University of Medical Sciences, Tehran, Iran.

Background: Diabetic foot ulcer is one of the common complications of diabetes disease that is costly and difficult to treat. This problem can lead to morbidity and even mortality. Ozone is a gas that can optimize cellular metabolism and, because of its antioxidant and antibacterial effects, can help the better healing of diabetic foot ulcer. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.11.060DOI Listing
December 2018
1 Read

Potential risk factors and outcomes of infection with multidrug resistance among diabetic patients having ulcers: 7 years study.

Diabetes Metab Syndr 2019 Jan - Feb;13(1):414-418. Epub 2018 Oct 13.

Former Professor of Endocrinology and Dean, Faculty of Medicine, Ex-Director, Rajiv Gandhi Centre for Diabetes and Endocrinology, Former Dean, Faculty of Medicine, J.N. Medical College, Aligarh Muslim University, Aligarh, 202002, India; Consultant, Diabetes and Superspeciality Center, Central Tower Ground Floor, Kela Nagar Chauraha, Aligarh, 202002, India.

Diabetes Mellitus is characterized as a hyperglycemic condition, which results due to alteration in the secretion of insulin or action of insulin. The development and spread of microorganisms is known as a key health concern, and such cases are growing drastically in hospitals and communities. Therefore, the study aims to determine the potential risk factors and infection outcomes among diabetic patients with multi drug resistance, who are suffering from foot ulcerations. Read More

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http://dx.doi.org/10.1016/j.dsx.2018.10.014DOI Listing
October 2018
2 Reads

The Diagnostic Classification of Critical Limb Ischemia.

Authors:
Nobuyoshi Azuma

Ann Vasc Dis 2018 Dec;11(4):449-457

Department of Vascular Surgery, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.

With the global epidemic of diabetes, diagnosis of critical limb ischemia (CLI) has become very complex due to mixture of microangiopathy, infection and sometimes neuropathy with the pure ischemia. We still sometimes encounter the patients with extensive tissue loss due to misdiagnosis of ischemia or infection in previous hospital. For adequate decision making of proper treatment selection for each critical ischemic limb without missing the adequate intervention timing, a new classification system good for not only vascular specialists but also gate keeping clinicians working in the era of diabetes has been desired. Read More

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http://dx.doi.org/10.3400/avd.ra.18-00122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326054PMC
December 2018
3 Reads

Synergistic in vitro effects of indocyanine green and ethylenediamine tetraacetate-mediated photodynamic antimicrobial chemotherapy combined with antibiotics for resistant bacterial biofilms in diabetic foot infection.

Photodiagnosis Photodyn Ther 2019 Jan 8. Epub 2019 Jan 8.

Department of Pharmacy, First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Background: Antibiotic resistance has emerged as one of the most important determinants in diabetic foot infections outcomes. Photodynamic antimicrobial chemotherapy (PACT) has been proposed as an alternative approach for inactivating bacteria, especially resistant bacterial biofilms. This research investigated the synergistic effects of PACT mediated by the photosensitizer indocyanine green (ICG) and ethylenediamine tetraacetate (EDTA) combined with antibiotics against common pathogens of diabetic foot ulcer infection, including Staphylococcus aureus and Pseudomonas aeruginosa, in vitro. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.01.010DOI Listing
January 2019
2 Reads

Current health and economic burden of chronic diabetic osteomyelitis.

Expert Rev Pharmacoecon Outcomes Res 2019 Jan 9:1-8. Epub 2019 Jan 9.

b Department of Foot and Ankle Surgery , Geisinger Community Medical Center , Scranton , PA , USA.

Introduction: Diabetic foot ulcer (DFU) prevalence is as high as 25% and 40-80% of DFUs become infected (DFI). About 20% of infected ulcers will spread to bone causing diabetic foot osteomyelitis (DFO). DFU costs Medicare $9-13 billion/year. Read More

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http://dx.doi.org/10.1080/14737167.2019.1567337DOI Listing
January 2019
3 Reads

Examining diabetic heel ulcers through an ecological lens: microbial community dynamics associated with healing and infection.

J Med Microbiol 2019 Feb 9;68(2):230-240. Epub 2019 Jan 9.

4​Foot Ulcer Trials Unit, Department of Diabetes and Endocrinology, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Purpose: While some micro-organisms, such as Staphylococcus aureus, are clearly implicated in causing tissue damage in diabetic foot ulcers (DFUs), our knowledge of the contribution of the entire microbiome to clinical outcomes is limited. We profiled the microbiome of a longitudinal sample series of 28 people with diabetes and DFUs of the heel in an attempt to better characterize the relationship between healing, infection and the microbiome.

Methodology: In total, 237 samples were analysed from 28 DFUs, collected at fortnightly intervals for 6 months or until healing. Read More

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http://www.microbiologyresearch.org/content/journal/jmm/10.1
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http://dx.doi.org/10.1099/jmm.0.000907DOI Listing
February 2019
10 Reads

Diabetic Foot Ulcers.

Authors:
Dara Grennan

JAMA 2019 01;321(1):114

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2018.18323DOI Listing
January 2019
2 Reads

Quantifying the costs and profitability of care for diabetic foot ulcers treated in a multidisciplinary setting.

J Vasc Surg 2019 Jan 1. Epub 2019 Jan 1.

Diabetic Foot and Wound Service, The Johns Hopkins Hospital, Baltimore, Md; Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Md; Center for Surgical Trials and Outcomes Research, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Md. Electronic address:

Objective: Increasing Wound, Ischemia, and foot Infection (WIfI) stage has previously been shown to be associated with prolonged wound healing time, higher number of surgical procedures, and increased cost of care in patients with diabetic foot ulcers (DFUs) treated in a multidisciplinary setting. However, the profitability of this care model is unknown. We aimed to quantify the hospital costs and net margins associated with multidisciplinary DFU care. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.10.097DOI Listing
January 2019
1 Read

Allogeneic keratinocyte for intractable chronic diabetic foot ulcers: A prospective observational study.

Int Wound J 2019 Jan 2. Epub 2019 Jan 2.

Department of Orthopedic Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Chronic diabetic foot ulcers (DFUs) are a common problem in patients with diabetes and are often difficult to treat. The application of newly developed dressing material in patients with chronic DFUs has been reported to be effective. The purpose of this study was to evaluate the usefulness of allogeneic keratinocyte treatment for chronic DFUs. Read More

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http://doi.wiley.com/10.1111/iwj.13061
Publisher Site
http://dx.doi.org/10.1111/iwj.13061DOI Listing
January 2019
5 Reads

Hybrid Foot Vein Arterialization in No-Option Patients With Critical Limb Ischemia: A Preliminary Report.

J Endovasc Ther 2019 Feb 28;26(1):7-17. Epub 2018 Dec 28.

3 Diabetic Foot Clinic, Humanitas Gavazzeni, Bergamo, Italy.

Purpose: To describe a preliminary experience in treating no-option critical limb ischemia (CLI) patients with a hybrid foot vein arterialization (HFVA) technique combining open plus endovascular approaches.

Materials And Methods: Between May 2016 and January 2018, 35 consecutive patients (mean age 68±12 years; 28 men) with 36 no-option CLI limbs underwent HFVA in our center. All limbs had grade 3 WIfI (Wound, Ischemia, and foot Infection) ischemia, and the wound classification was grade 1 in 4 (11%) limbs, grade 2 in 4 (11%), and grade 3 in 28 (78%). Read More

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http://dx.doi.org/10.1177/1526602818820792DOI Listing
February 2019
2 Reads

Limitations to the use of bromelain-based enzymatic debridement (NexoBrid) for treating diabetic foot burns: a case series of disappointing results.

Scars Burn Heal 2018 Jan-Dec;4:2059513118816534. Epub 2018 Dec 5.

Queen Victoria Hospital NHS Foundation Trust, East Grinstead, UK.

Background: Bromelain-based enzymatic debridement with Nexobrid® (Mediwound) is an alternative to traditional surgical tangential excision of deep dermal and full thickness burns. Early literature suggests that Nexobrid debridement could reduce the number of operations, infection rates, inpatient stay and the necessity for skin grafting to wounds by preserving viable tissue. To our knowledge there are no previous studies reporting the use of NexoBrid for treating burns in patients with established diabetic foot disease. Read More

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http://dx.doi.org/10.1177/2059513118816534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295758PMC
December 2018
2 Reads

Metatarsal Osteotomies for Treating Neuropathic Diabetic Foot Ulcers: A Meta-analysis.

Foot Ankle Spec 2018 Dec 19:1938640018819784. Epub 2018 Dec 19.

Department of Orthopedic Surgery, Lebanese American University Medical Center, Rizk Hospital, Lebanese American University, School of Medicine, Beirut, Lebanon (KY, MN, CA).

Diabetic foot ulcers (DFUs) are usually treated with conservative management based on debridement, topical agents, and nonsurgical off-loading; however, the recurrence rate following such standard care is reported to be high. In the case of recalcitrant or recurrent ulcers, a surgical off-loading technique such as the metatarsal osteotomy (MO) is indicated. Thus, the aim of this study is to conduct a meta-analysis evaluating the efficacy of MO in treating DFUs. Read More

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http://dx.doi.org/10.1177/1938640018819784DOI Listing
December 2018
7 Reads

Evaluate the Effect of Education Interventions in the Prevention of Diabetic Foot Ulcers through Knowledge of the Disease and Self-Care Practices in Saudi Arabia.

Open Access Maced J Med Sci 2018 Nov 15;6(11):2206-2213. Epub 2018 Nov 15.

University of Tabuk, Tabuk, Saudi Arabia.

Background: Diabetes mellitus places a substantial burden on society worldwide. Diabetic foot ulcers are a challenging problem for clinicians. Six generally accepted detriments to the healing of diabetic foot ulcers were identified: infection, glycaemic control, vascular supply, smoking, nutrition and deformity. Read More

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http://dx.doi.org/10.3889/oamjms.2018.439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290425PMC
November 2018
2 Reads

Skin Integrity and Infection Prevention Las Vegas: continuous delivery of oxygen enhances closure of diabetic foot ulcers.

Authors:

J Wound Care 2018 Dec;27(12):856-857

The 4th International Skin Integrity and Infection Prevention conference, hosted by the Journal of Wound Care and the University of Huddersfield in Las Vegas, included a series of sponsored symposia. This is the third in our series of reports on the key points of the symposia, which outlined the effects of hypoxia on wound healing, and how reduced oxygen levels can lead to chronic, non-healing wounds. The speaker, Mark Niederauer, explained what can be done to combat low oxygen levels using a new continuous diffusion of oxygen (CDO) device. Read More

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http://dx.doi.org/10.12968/jowc.2018.27.12.856DOI Listing
December 2018
4 Reads

A case of necrotizing fasciitis caused by Finegoldia magna in a patient with type 2 diabetes mellitus.

Infez Med 2018 Dec;26(4):359-363

Laboratory Medicine, San Bassiano Hospital, AULSS 7 Pedemontana, Bassano del Grappa, Italy.

Diabetes mellitus is one of the serious conditions associated with necrotizing fasciitis, a severe bacterial skin infection that spreads quickly and is characterized by extensive necrosis of the deep and superficial fascia resulting in devascularization and necrosis of the associated tissues. In addition to debridement and aggressive surgery procedures, the effectiveness of therapy depends on choosing the appropriate antibacterial agents. Hence the key to successful management is an early and accurate diagnosis. Read More

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December 2018
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Tc-Ceftizoxime: Synthesis, characterization and its use in diagnosis of diabetic foot osteomyelitis.

J Med Imaging Radiat Oncol 2019 Feb 10;63(1):61-68. Epub 2018 Dec 10.

Department of Nuclear Medicine, Nuclear Medicine, Oncology and Radiotherapy Institute (NORI), Islamabad, Pakistan.

Introduction: The diagnosis of diabetic foot osteomyelitis is crucial and challenging for the proper management of diabetic foot. Tc labelled Ceftizoxime was used as a non-invasive diagnostic agent for diabetic foot osteomyelitis.

Methods: Ceftizoxime [CFT], a third generation cephalosporin, was used in a simple and direct method for the synthesis of TcO labelled infection imaging agent with stannous chloride as reducing agent. Read More

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http://dx.doi.org/10.1111/1754-9485.12841DOI Listing
February 2019
3 Reads

Histopathological changes in major amputations due to diabetic foot - a review.

Rom J Morphol Embryol 2018 ;59(3):699-702

Discipline of Pharmacology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;

Diabetes mellitus is the leading cause of non-traumatic amputations worldwide. Ulcer of the diabetic foot is one of the most prevalent lesions of diabetic patients and it occurs in the natural evolution of the disease as a tardive complication. Neuropathy is the main determinant of foot ulcer. Read More

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December 2018
3 Reads

Innocuous "foot lump" in patient with diabetes mellitus: A manifestation of phaeohyphomycosis.

Foot (Edinb) 2018 Nov 28;38:4-7. Epub 2018 Nov 28.

Department of Endocrinology, PGIMER, Chandigarh, 160012, IndiaIndia.

Invasive mycotic infection presenting as "foot lump" in an immunocompetent patient is extremely rare. The case highlights the difficulty in diagnosis of fungal infections of foot including attempts to isolate the fungus and non-response to anti-fungal agents. A 64-year-old lady with T2DM for four years presented with painless, gradually progressive swelling over plantar aspect of left mid-foot for six months. Read More

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http://dx.doi.org/10.1016/j.foot.2018.11.005DOI Listing
November 2018
2 Reads

Bacteriologic analysis of bone biopsy from diabetic foot infections within a VA patient population.

Foot (Edinb) 2018 Oct 9;38:1-3. Epub 2018 Oct 9.

California School of Podiatric Medicine, University of California, San Francisco
, United States. Electronic address:

Diabetic patients with foot infections were evaluated over a 5-year period from April 2005 to March 2010. Cultures were obtained from 92 patients after surgical debridement. All of the patients were classified as "severe" diabetic foot infections (DFIs) and PEDIS grade 4. Read More

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http://dx.doi.org/10.1016/j.foot.2018.10.004DOI Listing
October 2018
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A Comparative Study of the Reverse Sural Fascio-Cutaneous Flap Outcomes in the Management of Foot and Ankle Soft Tissue Defects in Diabetic and Trauma Patients.

Foot Ankle Spec 2018 Dec 7:1938640018816378. Epub 2018 Dec 7.

Department of Orthopedic Surgery, Lebanese American Hospital Medical Center-Rizk Hospital, Beirut, Lebanon (CA, CS, TH, KY), Center for Evidence-based Anatomy, Sports and Orthopedic Research, Beirut, Lebanon.

Introduction: Soft tissue defects in the distal leg and foot are challenging conditions for reconstruction. The widely used reverse sural fascio-cutaneous flap (RSFCF) has been reported with large variation in complication frequency. Some authors reported higher complications in the diabetic population when compared with trauma patients. Read More

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http://dx.doi.org/10.1177/1938640018816378DOI Listing
December 2018
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Recognizing Common Skin and Soft Tissue Infections in the Nephrology Clinic.

Blood Purif 2018 Dec 5:1-6. Epub 2018 Dec 5.

Renal failure patients have an increased risk of infection, including skin and soft tissue infections. This increased susceptibility is multifactorial, due to the conditions causing the renal failure as well as complications of treatment and renal failure's innate effects on patient health. These infections have a significant impact on patient morbidity, increased hospital and procedural demands, and the cost of health care. Read More

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http://dx.doi.org/10.1159/000494594DOI Listing
December 2018
12 Reads

Diabetic foot ulcers with myiasis: a potential route for resistance gene dissemination for enterococci?

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):879

Laboratório de Estudo de Dípteros, Departamento de Microbiologia e Parasitologia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

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http://dx.doi.org/10.1590/0037-8682-0335-2017DOI Listing
February 2019
2 Reads

Risk factors for mortality in patients with diabetic foot infections: a prospective cohort study.

Intern Med J 2018 Dec 4. Epub 2018 Dec 4.

Staff Specialist, Department of Infectious Diseases, Royal Darwin Hospital, Tiwi, NT, Australia.

Background: An increasing prevalence of diabetes mellitus has led to a high risk of diabetic foot infections (DFI) and associated morbidity. However, little is known about the relationship between DFI and mortality.

Aims: To investigate the risk of mortality and associated factors in patients with DFI in an Australian context. Read More

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http://doi.wiley.com/10.1111/imj.14184
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http://dx.doi.org/10.1111/imj.14184DOI Listing
December 2018
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Ertapenem for osteoarticular infections in obese patients: a pharmacokinetic study of plasma and bone concentrations.

Eur J Clin Pharmacol 2018 Dec 4. Epub 2018 Dec 4.

Faculty of Health and Medical Sciences, Harry Perkins Research Institute, Fiona Stanley Hospital, University of Western Australia, PO Box 404, Bull Creek 6149, Murdoch, Western Australia, Australia.

Purpose: Ertapenem is used off-label to treat osteoarticular infections but there are few pharmacokinetic (PK) data to guide optimal dosing strategies in patients who may be obese with multiple co-morbidities including diabetes and peripheral vascular disease.

Methods: Participants undergoing lower limb amputation or elective joint arthroplasty received a dose of intravenous ertapenem prior to surgery. Eight plasma samples were collected over 24 h, together with at least one bone sample per patient. Read More

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http://link.springer.com/10.1007/s00228-018-2597-z
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http://dx.doi.org/10.1007/s00228-018-2597-zDOI Listing
December 2018
12 Reads

Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis.

Ann Vasc Surg 2018 Nov 26. Epub 2018 Nov 26.

Academic Vascular Surgical Unit, Hull Royal Infirmary, Hull, UK.

Background: Diabetes mellitus is one of the most common chronic diseases worldwide. Diabetic foot ulcers (DFUs) occur in over 10% of diabetic patients and are associated with high morbidity. Clinical trials have shown benefit from extracorporeal shockwave therapy (ESWT) in a DFU healing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08905096183087
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http://dx.doi.org/10.1016/j.avsg.2018.10.013DOI Listing
November 2018
20 Reads
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Performance of the automated multiplex PCR Unyvero implant and tissue infections system in the management of diabetic foot osteomyelitis.

Future Microbiol 2018 Nov 29. Epub 2018 Nov 29.

U1047, INSERM, University Montpellier, Department of Microbiology, University Hospital Nimes, Nîmes, France.

Aim: We evaluated the performance of Unyvero implant and tissue infections system (ITI) application (Curetis) to diagnose Diabetic Foot Osteomyelitis (DFOM).

Patients & Methods: The study was conducted in the Diabetic Foot reference center of Nîmes University Hospital (France) from 1 December 2016 to 31 May 2017. We compared the Unyvero ITI PCR to conventional culture and alternative molecular approaches. Read More

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https://www.futuremedicine.com/doi/10.2217/fmb-2018-0213
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http://dx.doi.org/10.2217/fmb-2018-0213DOI Listing
November 2018
5 Reads

Frequency of Fungal Species of Onychomycosis between Diabetic and Non-Diabetic Patients.

Mymensingh Med J 2018 Oct;27(4):752-756

Dr Sharmin Sultana, Medical Officer, Department of Dermatology & Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Onychomycosis is a common nail problem in our country. Diabetic patients are more prone to develop onychomycosis. Various types of fungi are the causative agents of nail infections. Read More

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October 2018
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Prevalence of Extended Spectrum β-Lactamases in Multi-drug Resistant Pseudomonas aeruginosa from Diabetic Foot Patients.

Endocr Metab Immune Disord Drug Targets 2018 Nov 27. Epub 2018 Nov 27.

Institute of Basic Medical Sciences, Khyber Medical University, Peshawar. Pakistan.

Background: Pseudomonas aeruginosa is one of the major pathogen associated with acute tissue damage in patients with diabetic foot ulcer (DFU). Antibiotic resistance in P. aeruginosa often bodes unpredictable and unfavourable clinical outcomes, owing to a variety of intrinsic and acquired molecular mechanisms. Read More

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http://www.eurekaselect.com/167797/article
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http://dx.doi.org/10.2174/1871530319666181128095753DOI Listing
November 2018
6 Reads