Search our Database of Scientific Publications and Authors

I’m looking for a

    3572 results match your criteria Diabetic Foot Infections

    1 OF 72

    Effectiveness of viable cryopreserved placental membranes for management of diabetic foot ulcers in a real world setting.
    Wound Repair Regen 2018 Apr 23. Epub 2018 Apr 23.
    Osiris Therapeutics, Inc., Columbia, MD.
    In a multicenter randomized controlled trial (RCT), the use of viable cryopreserved placental membrane (vCPM) for chronic diabetic foot ulcers (DFUs) resulted in a higher proportion of wound closure in comparison to good wound care: 62% vs. 21% (p < 0.01). Read More

    The Role of Serum Procalcitonin, Interleukin-6, and Fibrinogen Levels in Differential Diagnosis of Diabetic Foot Ulcer Infection.
    J Diabetes Res 2018 21;2018:7104352. Epub 2018 Feb 21.
    Department of Clinical Microbiology and Infectious Diseases, Dumlupınar University Faculty of Medicine, 43020 Kutahya, Turkey.
    Aims: We aimed to evaluate the roles of interleukin-6 (IL-6), PCT, and fibrinogen levels in the differential diagnosis of the patients with infected diabetic foot ulcer (IDFU) and noninfected diabetic foot ulcer (NIDFU) and to compare those with C-reactive protein (CRP), white blood cell (WBC), and erythrocyte sedimentation rate (ESR).

    Methods: Patients over 18 years with a diagnosis of type 2 diabetes mellitus and DFU who were followed up in our hospital between 1 January 2016 and 1 January 2017 were included in the study. In addition to this patient group, patients with diabetes but without DFU were determined as the control group. Read More

    Contemporary critical limb ischemia: Asian multidisciplinary consensus statement on the collaboration between endovascular therapy and wound care.
    Cardiovasc Interv Ther 2018 Apr 13. Epub 2018 Apr 13.
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
    The burden of peripheral artery disease (PAD) and diabetes in Asia is projected to increase. Asia also has the highest incidence and prevalence of end-stage renal disease (ESRD) in the world. Therefore, most Asian patients with PAD might have diabetic PAD or ESRD-related PAD. Read More

    Managing diabetic foot infections: a survey of Australasian infectious diseases clinicians.
    J Foot Ankle Res 2018 10;11:13. Epub 2018 Apr 10.
    19School of Clinical Sciences, Queensland University of Technology, Victoria Park Rd, Kelvin Grove, QLD Australia.
    Background: Diabetic foot infections (DFI) present a major morbidity, mortality and economic challenge for the tertiary health sector. However, lack of high quality evidence for specific treatment regimens for patients with DFIs may result in inconsistent management. This study aimed to identify DFI caseload proportion and patterns of clinical practice of Infectious Diseases (ID) Physicians and Trainees within Australia and New Zealand. Read More

    Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model.
    Exp Mol Med 2018 Apr 13;50(4):29. Epub 2018 Apr 13.
    Department of Interventional & Vascular Surgery, Tenth People's Hospital of Tongji University, No. 301 Middle Yan Chang Road, Shanghai, 200072, China.
    Diabetic foot ulcers (DFU) increase the risks of infection and amputation in patients with diabetes mellitus (DM). The impaired function and senescence of endothelial progenitor cells (EPCs) and high glucose-induced ROS likely exacerbate DFUs. We assessed EPCs in 60 patients with DM in a hospital or primary care setting. Read More

    Prospective Analysis of Surgical Bone Margins After Partial Foot Amputation in Diabetic Patients Admitted With Moderate to Severe Foot Infections.
    Foot Ankle Spec 2018 Apr 1:1938640018770285. Epub 2018 Apr 1.
    Division of Metabolism, Endrocrinology, and Diabetes, Department of Internal Medicine, Ann Arbor, Michigan (BMS, JSM).
    Background: Osteomyelitis is common in diabetic foot infections and medical management can lead to poor outcomes. Surgical management involves sending histopathologic and microbiologic specimens which guides future intervention. We examined the effect of obtainment of surgical margins in patients undergoing forefoot amputations to identify patient characteristics associated with outcomes. Read More

    Microbiology and Antimicrobial Therapy for Diabetic Foot Infections.
    Infect Chemother 2018 Mar;50(1):11-20
    Southwestern Academic Limb Salvage Alliance (SALSA), Department of Surgery of Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
    In addition to being the prime factor associated with amputation, diabetic foot infections (DFIs) are associated with major morbidity, increasing mortality, and reduced quality of life. The choice of appropriate antibiotics is very important in order to reduce treatment failure, antimicrobial resistance, adverse events, and costs. We reviewed articles on microbiology and antimicrobial therapy and discuss antibiotic selection in Korean patients with DFIs. Read More

    Bone and joint infection.
    Clin Med (Lond) 2018 Mar;18(2):150-154
    Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK
    Bone and joint infections include septic arthritis, prosthetic joint infections, osteomyelitis, spinal infections (discitis, vertebral osteomyelitis and epidural abscess) and diabetic foot osteomyelitis. All of these may present through the acute medical take. This article discusses the pathogenesis of infection and highlights the importance of taking a careful history and fully examining the patient. Read More

    The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification independently predicts wound healing in diabetic foot ulcers.
    J Vasc Surg 2018 Apr 2. Epub 2018 Apr 2.
    Diabetic Foot and Wound Service, The Johns Hopkins Hospital, Baltimore, Md; Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Md. Electronic address:
    Objective: Previous studies have reported correlation between the Wound, Ischemia, and foot Infection (WIfI) classification system and wound healing time on unadjusted analyses. However, in the only multivariable analysis to date, WIfI stage was not predictive of wound healing. Our aim was to examine the association between WIfI classification and wound healing after risk adjustment in patients with diabetic foot ulcers (DFUs) treated in a multidisciplinary setting. Read More

    Managing the Diabetic Foot Ulcer: How Best Practices Fit the Real 2018 United States.
    Surg Technol Int 2018 Mar 29;31. Epub 2018 Mar 29.
    Vice Chairman of General Surgery, Director of Surgical Clinical Research, Mount Sinai St. Luke's - West Hospitals, New York, New York.
    Diabetes Mellitus is a serious systemic illness that has an epidemic-like increasing prevalence in the United States, as well as the rest of the world. With the increasing number of people with diabetes comes the higher incidence of diabetes-related complications. One of these known complications, diabetic foot ulcers (DFU), has an estimated lifetime incidence of 15% in diabetics. Read More

    Improvement in Quality of Life Following Operative Correction of Midtarsal Charcot Foot Deformity.
    Foot Ankle Int 2018 Mar 1:1071100718762138. Epub 2018 Mar 1.
    1 Department of Orthopaedic Surgery & Rehabilitation, Loyola University Health System, Maywood, IL, USA.
    Background: Patients with Charcot foot arthropathy report a poor quality of life following the development of deformity. Their quality of life is often not improved with "successful" historic accommodative treatment. There is increased current interest in operative correction of the acquired deformity with the stated goals of achieving both the traditional goals of resolution of infection and limb salvage as well as the desire to improve quality of life. Read More

    A Perioperative Approach to Increase Limb Salvage When Treating Foot Ulcers in Patients With Diabetes.
    AORN J 2018 Apr;107(4):431-440
    Foot ulceration in patients with diabetes increases the risk of lower extremity amputation. Major amputations produce substantial adverse consequences, increase length of hospital stay, diminish quality of life, and increase mortality. In this article, we describe approaches that decrease amputations and improve the quality of life for patients with diabetes and foot ulcers. Read More

    Burn aggravated infected wart in a patient with type 2 diabetes: a medical challenge.
    BMJ Case Rep 2018 Mar 28;2018. Epub 2018 Mar 28.
    Department of Pharmaceutics, Hamdard University, Karachi, Pakistan.
    An infectious wart of foot in a patient with diabetics is a medical challenge, and it gets worse when aggravated with burns. We present a case of a 67-year-old Pakistani man, diabetic for 20 years presented at our healthcare centre. While awaiting his culture sensitivity report, he was prescribed an empiric antibiotic therapy. Read More

    Molecular and culture based assessment of bacterial pathogens in subjects with diabetic foot ulcer.
    Diabetes Metab Syndr 2018 Mar 16. Epub 2018 Mar 16.
    Rajiv Gandhi Centre for Diabetes and Endocrinology, J.N Medical College, Aligarh Muslim University, Aligarh, U.P, 202002, India. Electronic address:
    Introduction: Expeditious and precise discerning of bacterial pathogens is a fundamental grail, of clinical diagnostic microbiology. Genotypic detection is a budding substitute to recognize phenotypic culture based processes in bacterial identification.

    Aims: We report a comparative evaluation of biochemical and genomic-based assays for exploring the commonest bacterial flora of infected diabetic foot ulcers along with clinical variables of subjects enrolled. Read More

    Minimal Invasive Fixation Can Decrease Infection Rates in Diabetic and Obese Patients With Severe Ankle Fracture and Syndesmotic Injury.
    Foot Ankle Spec 2018 Mar 1:1938640018766627. Epub 2018 Mar 1.
    Department of Orthopaedic Surgery, University of Toledo Medical Center, Toledo, Ohio.
    Background: Ankle fractures involving syndesmosis disruption cause severely unstable joint conditions. Traditional invasive operations put certain patient groups at an increased risk of infection. There is limited literature discussing the outcomes of minimally invasive fixation of severe ankle fractures including syndesmotic injury, as clinicians may be tempted to treat these difficult cases with open reduction internal fixation (ORIF). Read More

    Virulence Factor Genes in Staphylococcus aureus Isolated From Diabetic Foot Soft Tissue and Bone Infections.
    Int J Low Extrem Wounds 2018 Mar 22;17(1):36-41. Epub 2018 Mar 22.
    5 University of Washington, Seattle, WA, USA.
    The aim of this study is to describe the presence of genes encoding for 4 virulence factors (pvl, eta, etb, and tsst), as well as the mecA gene conferring resistance to beta-lactam antibiotics, in patients with diabetes and a staphylococcal foot infection. We have also analyzed whether isolates of Staphylococcus aureus from bone infections have a different profile for these genes compared with those from exclusively soft tissue infections. In this cross-sectional study of a prospectively recruited series of patients admitted to the Diabetic Foot Unit, San Juan de Dios Hospital, San José, Costa Rica with a moderate or severe diabetic foot infection (DFI), we collected samples from infected soft tissue and from bone during debridement. Read More

    New insights into classification, epidemiology and microbiology of SSTIs, including diabetic foot infections.
    Infez Med 2018 Mar;26(1):3-14
    Department of Hygiene, University of Salerno, Italy.
    Skin and soft tissue infections (SSTIs) involve a heterogeneous group of entities with different clinical presentations classified according to several specific criteria. Because of their great variability, their incidence and prevalence is difficult to accurately determine. Yet it is generally thought that the rate of SSTIs is globally increasing due to an aging population, strictly associated with the increase in the number of critical and immunocompromised patients. Read More

    Computerized planimetry evaluation of hyperbaric oxygen therapy in the treatment of diabetic foot.
    Adv Clin Exp Med 2018 Jan;27(1):39-44
    Centre for Burns Treatment, Siemianowice Śląskie, Poland.
    Background: Diabetic foot ulcer is one of the major complications of diabetes mellitus in adults.

    Objectives: The aim of the study was to conduct a planimetry evaluation of the effectiveness of hyperbaric oxygen therapy (HBOT) in the treatment of patients with vascular disorders caused by diabetic foot.

    Material And Methods: The study included 94 patients, 30 females (32%) and 64 males (68%), aged 33-76 years, with diabetes lasting 1. Read More

    Pseudomonas aeruginosa infection alters the macrophage phenotype switching process during wound healing in diabetic mice.
    Cell Biol Int 2018 Mar 7. Epub 2018 Mar 7.
    Shanghai Tenth People's Hospital and Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai, China.
    Macrophages play critical roles in wound healing process. They switch from "classically activated" (M1) phenotype in the early inflammatory phase to "alternatively activated" (M2) phenotype in the later healing phase. However, the dynamic process of macrophage phenotype switching in diabetic wounds burdened with bacteria is unclear. Read More

    An Overview on Diabetic foot Infections, including Issues Related to Associated Pain, Hyperglycemia and Limb Ischemia.
    Curr Pharm Des 2018 Mar 2. Epub 2018 Mar 2.
    Service of Infectious Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Switzerland.
    Factors strongly related to the risk of developing diabetic foot infections include vascular, neuropathic and hyperglycemic complications of long-standing diabetes mellitus. These infections are common and serious, posing a worldwide burden on administrative providers of healthcare, patients and physicians. The most appropriate approach to these infections is with a multidisciplinary team. Read More

    Reconstruction of diabetic lower leg and foot soft tissue defects using thoracodorsal artery perforator chimeric flaps.
    Microsurgery 2018 Mar 5. Epub 2018 Mar 5.
    Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul National University Hospital, Seoul, Korea.
    Background: Reconstruction of complicated diabetic lower leg and foot defects involving multiple tissue components remains a challenge. The purpose of this report is to introduce thoracodorsal artery perforator (TDAP) chimeric flaps for reconstructing diabetic lower leg and foot soft tissue defects.

    Patients And Methods: Between April 2010 and August 2016, 17 patients with multiple diabetic lower leg and foot defects underwent reconstruction with TDAP chimeric flaps. Read More

    Intracardiac Abscess and Pacemaker Lead Infection Secondary to Hematogenous Dissemination of Methicillin-Sensitive Staphylococcus Aureus from a Prior Diabetic Foot Ulcer and Osteomyelitis.
    Am J Case Rep 2018 Mar 1;19:224-228. Epub 2018 Mar 1.
    Department of Critical Care and Pulmonology, Camden Clark Medical Center, Parkersburg, WV, USA.
    BACKGROUND Intracardiac abscesses are an unusual occurrence in developed countries. With the increase in use of implantable cardiac devices, the increase use of and advancements in antibiotics, and the longevity of patients with cardiac devices, one may expect an increase in such infections; however, case reports are rare. We are presenting a case in which hematogenous dissemination of methicillin-sensitive Staphylococcus aureus (MSSA) infection from a lower extremity diabetic ulcer propagated into an infected pacemaker lead and ultimately an intracardiac abscess of the right atrium. Read More

    Risks associated with SGLT2 Inhibitors: An Overview.
    Curr Drug Saf 2018 Feb 25. Epub 2018 Feb 25.
    Department of Pharmacology, Indo-Soviet Friendship College of pharmacy (ISFCP), Moga, Punjab. India.
    Sodium glucose co-transport 2 inhibitors (SGLT2-i) are the new class of anti-diabetic medications which are the recently approved (2013) by FDA for the treatment of diabetes. These inhibitors block the SGLT2 protein which involved in glucose reabsorption from proximal renal tubule which results in increased glucose excretion and lower blood glucose levels. These inhibitors exert favourable effects beyond glucose control such as consistent body weight, blood pressure, and serum uric acid reductions. Read More

    Diabetic Foot Infection: the role of PET/CT Imaging.
    Curr Pharm Des 2018 Feb 26. Epub 2018 Feb 26.
    Department of Nuclear Medicine, Rambam HealthCare Campus & 2R. Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa. Israel.
    Osteomyelitis in the diabetic foot can be difficult to diagnose and has serious consequences. Although 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) positron emission tomography (PET) was traditionally used in oncology, it is emerging as a useful method in inflammatory and infectious entities. In this chapter, original research articles, meta-analyses, and reviews on the performance of FDG PET in diagnosing osteomyelitis in the diabetic foot will be discussed. Read More

    New imaging tracers for the infected diabetic foot (nuclear and optical imaging).
    Curr Pharm Des 2018 Feb 26. Epub 2018 Feb 26.
    University of Groningen, University Medical Center Groningen, Department of Nuclear Medicine and Molecular Imaging, Groningen. Netherlands.
    Diabetic foot infections (DFIs) are associated with increased morbidity, an economic burden on patients, their families and healthcare systems and increased mortality. Early diagnosis with prompt, appropriate and adequate treatment of the infected diabetic foot is crucial. The determination of DFIs, however, may be quite perplexing and invasive. Read More

    Leukocyte imaging of the diabetic foot.
    Curr Pharm Des 2018 Feb 26. Epub 2018 Feb 26.
    Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, "Sapienza" University of Rome. Italy.
    Background: Diagnosing diabetic foot infection is often difficult, despite several available diagnostic methods. Amongst these, several imaging modalities exist to evaluate the diabetic foot in case of a suspected osteomyelitis. Nuclear Medicine, in particular, offers a variety of radiopharmaceuticals and techniques. Read More

    Appraisal of Biofilm Formation in Diabetic Foot Infections by Comparing Phenotypic Methods With the Ultrastructural Analysis.
    J Foot Ankle Surg 2018 Mar - Apr;57(2):309-315
    Assistant Professor, Department of Microbiology, Medical Microbiology Laboratory, School of Bioscience, Periyar University, Salem, India. Electronic address:
    Diabetic patients are more prone to the development of foot ulcers, because their underlying tissues are exposed to colonization by various pathogenic organisms. Hence, biofilm formation plays a vital role in disease progression by antibiotic resistance to the pathogen found in foot infections. The present study has demonstrated the correlation of biofilm assay with the clinical characteristics of diabetic foot infection. Read More

    Physical activity and exercise on diabetic foot related outcomes: A systematic review.
    Diabetes Res Clin Pract 2018 Feb 23;139:81-90. Epub 2018 Feb 23.
    Research Center in Sports Sciences, Health Sciences and Human Development, Vila Real, Portugal; University of Trás-os-Montes e Alto Douro, Vila Real, Portugal. Electronic address:
    Background: Diabetic foot is one of the most common complications of diabetes. It has the potential risk of pathologic consequences including infection, ulceration and amputation, but a growing body of evidence suggests that physical activity and exercise may improve diabetic foot outcomes.

    Objective: To analyze de effects of exercise and physical activity interventions on diabetic foot outcomes. Read More

    Influence of multidrug resistant organisms on the outcome of diabetic foot infection.
    Int J Infect Dis 2018 Feb 21;70:10-14. Epub 2018 Feb 21.
    Medeniyet University Medical Faculty, Goztepe Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.
    Objectives: We described the clinical outcomes of the diabetic patients who had foot infections with multidrug resistant organisms.

    Methods: We included the patients with diabetic foot infections (DFI) from 19 centers, between May 2011 and December 2015. Infection was defined according to IDSA DFI guidelines. Read More

    In vitro antibacterial and time-kill assay of ethanolic extract of Davilla nitida bark on multidrug resistant bacteria isolated from diabetic foot lesions.
    Nat Prod Res 2018 Feb 23:1-6. Epub 2018 Feb 23.
    e Departamento de Genética e Evolução , Universidade Federal de São Carlos , São Carlos , Brazil.
    This study reported the antimicrobial activity of the bark extract of Davilla nitida on multidrug resistant bacteria isolated from Diabetic Foot Infections. Antibacterial activity of the bark extract was evaluated by agar Disk-Diffusion (DD), Broth Dilution (BD), Checkerboard and Time-kill methods. The extract showed a significant antibacterial activity against all groups of bacteria tested. Read More

    Local Antibiotic Delivery Systems: Current and Future Applications for Diabetic Foot Infections.
    Int J Low Extrem Wounds 2018 Mar 20;17(1):14-21. Epub 2018 Feb 20.
    1 Manchester Royal Infirmary, Manchester, UK.
    Foot infections are common among diabetic patients with peripheral neuropathy and/or peripheral arterial disease, and it can be the pivotal event leading to a minor or major amputation of the lower extremity. Treatment of diabetic foot infections, especially deep-seated ones, remains challenging, in part because impaired blood perfusion and the presence of biofilms can impair the effectiveness of systemic antibiotics. The local application of antibiotics is an emerging field in the treatment of diabetic foot infections, with demonstrable advantages. Read More

    Proinsulin-expressing dendritic cells in type 2 neuropathic diabetic patients with and without foot lesions.
    FASEB J 2018 Feb 12:fj201701279RR. Epub 2018 Feb 12.
    Department of Pathology, Santa Maria di Ca' Foncello Hospital, Treviso, Italy.
    Diabetic neuropathy is the most common complication of diabetes and is frequently associated with foot ischemia and infection, but its pathogenesis is controversial. We hypothesized that proinsulin expression in peripheral blood mononuclear cells is a process relevant to this condition and could represent a link among hyperglycemia, nerve susceptibility, and diabetic foot lesions. We assessed proinsulin expression by using flow cytometry in dendritic cells from control participants and patients with type 2 diabetic with or without peripheral neuropathy or accompanied by diabetic foot. Read More

    The Diabetic Foot Attack: "'Tis Too Late to Retreat!"
    Int J Low Extrem Wounds 2018 Mar 12;17(1):7-13. Epub 2018 Feb 12.
    3 Democritus University of Thrace, Alexandroupolis, Greece.
    The "diabetic foot attack" is one of the most devastating presentations of diabetic foot disease, typically presenting as an acutely inflamed foot with rapidly progressive skin and tissue necrosis, at times associated with significant systemic symptoms. Without intervention, it may escalate over hours to limb-threatening proportions and poses a high amputation risk. There are only best practice approaches but no international protocols to guide management. Read More

    Could essential oils enhance biopolymers performance for wound healing? A systematic review.
    Phytomedicine 2018 Jan 28;38:57-65. Epub 2017 Oct 28.
    Lab3Bio (Laboratorio de Biomateriales, Biomecánica y Bioinstrumentación), Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín, 25 de Mayo 1143, B1650HMK General San Martín, Provincia de Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, C1425FQB CABA, Argentina.
    Background: Millions of people in the world suffer from chronic wounds of different etiologies such as diabetic foot and leg ulcers, without solutions nowadays. Molecules obtained from plants offer an alternative to aid wound healing. Strong evidence about essential oils (EO) anti-inflammatory and antimicrobial properties is thoroughly described in literature and their chemical compositions are well characterized. Read More

    Calcium alginate-based antimicrobial film dressings for potential healing of infected foot ulcers.
    Ther Deliv 2018 Feb;9(3):185-204
    Department of Pharmaceutical, Chemical & Environmental Sciences, Faculty of Engineering & Science, University of Greenwich, Medway, Central Ave Chatham Maritime, Kent, ME4 4TB, UK.
    Aim: Diabetic foot ulcers are susceptible to infection and nonmedicated dressings are ineffective because they have no antimicrobial activity. This study aimed to develop antimicrobial films to deliver ciprofloxacin for treating bacterial infection. Results/methodology: Ciprofloxacin-loaded calcium alginate films were characterized for porosity, swelling, equilibrium water content, water absorption, water vapor transmission, evaporative water loss, moisture content, mechanical strength, adhesion, IR spectroscopy, scanning electron microscopy, x-ray diffraction, drug release, cytotoxicity and antimicrobial activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Read More

    Correction of ankle and hind foot deformity in Charcot neuroarthropathy using a retrograde hind foot nail-The Kings' Experience.
    Foot Ankle Surg 2017 Apr 28. Epub 2017 Apr 28.
    Diabetic Foot Unit, Kings College Hospital NHS Foundation Trust, United Kingdom.
    Background: Corrective fusion for the unstable deformed hind foot and mid foot in Charcot Neuroarthropathy (CN) is quite challenging and is best done in tertiary centres under the supervision of multidisciplinary teams.

    Methods: We present a follow up to our initial report with a series of 42 hind foot corrections in 40 patients from a tertiary level teaching hospital in the United Kingdom. The mean patient age was 59 (33-82). Read More

    Minimally Invasive Plate Osteosynthesis for Treatment of Ankle Fractures in High-Risk Patients.
    J Foot Ankle Surg 2018 May - Jun;57(3):494-500. Epub 2018 Feb 2.
    Attending Staff, Department of Foot and Ankle Surgery, Palo Alto Foundation Medical Group, Dublin, CA.
    Wound healing problems are the most common complication after open reduction with internal fixation (ORIF) of unstable ankle fractures. The incidence is especially high among elderly patients with medical comorbidities and patients with compromised soft tissues. Minimally invasive plate osteosynthesis (MIPO) might provide a safer alternative to ORIF by preventing extensive soft tissue dissection and preserving the blood supply. Read More

    Extended Islanded Reverse Sural Artery flap for Staged Reconstruction of Foot Defects Proximal to Toes.
    J Coll Physicians Surg Pak 2018 Feb;28(2):126-128
    Department of Plastic Surgery, Jinnah Burn and Reconstructive Surgery Center, Allama Iqbal Medical College, Lahore.
    Obective:To assess the outcome of extended delayed reverse sural artery flap for reconstruction of foot defects proximal to toes in terms of flap survival, complication and extended area.

    Study Design: Case series.

    Place And Duration Of Study: Jinnah Burn and Reconstructive Surgery Centre, Lahore, from February 2015 to April 2017. Read More

    CODIFI (Concordance in Diabetic Foot Ulcer Infection): a cross-sectional study of wound swab versus tissue sampling in infected diabetic foot ulcers in England.
    BMJ Open 2018 01 31;8(1):e019437. Epub 2018 Jan 31.
    Clinical Trials Research Unit, University of Leeds, Leeds, UK.
    Objective: To determine the extent of agreement and patterns of disagreement between wound swab and tissue samples in patients with an infected diabetic foot ulcer (DFU).

    Design: Multicentre, prospective, cross-sectional study.

    Setting: Primary and secondary care foot ulcer/diabetic outpatient clinics and hospital wards across England. Read More

    [The conspicuous leg].
    Internist (Berl) 2018 Mar;59(3):227-233
    Medizinische Klinik 2, Städtisches Klinikum Dresden, Friedrichstr. 41, 01067, Dresden, Deutschland.
    Symptoms of the leg or of both legs, may indicate a need for evaluation and/or treatment, which must be clarified urgently or even as an emergency situation. Among the diseases which must be considered from a vascular viewpoint are critical limb ischemia, suspicion of deep leg vein thrombosis and special forms of venous insufficiency. With respect to infections erysipelas and the syndrome of infected diabetic foot must be considered as well as peripheral and central leg paresis as orthopedic and neurological disorders, respectively. Read More

    Association between biofilm and multi/extensive drug resistance in diabetic foot infection.
    Int J Clin Pract 2018 Mar 30;72(3):e13060. Epub 2018 Jan 30.
    Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
    Purpose: We aimed to determine significant risk factors for biofilm production and to investigate the association between antimicrobial resistance profile and biofilm formation in the bacterial isolates obtained from patients with diabetic foot infection (DFI).

    Methods: Demographic, clinical, laboratory and outcome data of 165 patients, prospectively recorded and followed between January 2008 and December 2015 by a multidisciplinary committee, were analysed. Standard microbiological methods were adopted. Read More

    The current role of glycopeptides in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in not neutropenic adults: the viewpoint of a group of Italian experts.
    J Chemother 2018 Jan 30:1-15. Epub 2018 Jan 30.
    c Università degli Studi di Bologna/Ospedale Sant'Orsola-Malpighi, Bologna, Italy - Dipartimento di Scienze Mediche e Chirurgiche, Settore Malattie Infettive.
    Staphylococcus aureus is still an important problem in clinical and therapeutic area, worldwide. In Italy, in recent years, methicillin resistance remained stable, yet considerably high, the percentage of strains of MRSA being around 40%. It was deemed interesting and timely to carry out a consensus conference using the RAND/UCLA method to collect the opinion of a group of experts in infectious diseases on the role of glycopeptides in the management of MRSA infections within several clinical scenarios and namely in pneumonia, bacteremia and endocarditis, joint replacement infections, skin and soft tissue infections, diabetic foot, abdominal infections and central nervous system infections. Read More

    Update on management of diabetic foot ulcers.
    Ann N Y Acad Sci 2018 Jan;1411(1):153-165
    Division of Endocrinology, Diabetes, & Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
    Diabetic foot ulcers (DFUs) are a serious complication of diabetes that results in significant morbidity and mortality. Mortality rates associated with the development of a DFU are estimated to be 5% in the first 12 months, and 5-year morality rates have been estimated at 42%. The standard practices in DFU management include surgical debridement, dressings to facilitate a moist wound environment and exudate control, wound off-loading, vascular assessment, and infection and glycemic control. Read More

    Metataxonomic approach to decipher the polymicrobial burden in diabetic foot ulcer and its biofilm mode of infection.
    Int Wound J 2018 Jan 22. Epub 2018 Jan 22.
    Cholera and Biofilm Research Lab, Rajiv Gandhi Centre for Biotechnology, Trivandrum, Kerala, India.
    Chronic diabetic foot is a global burden affecting millions of people, and the chronicity of an ulcer is directly linked to the diverse bacterial burden and its biofilm mode of infection. The bacterial diversity of 100 chronic diabetic ulcer samples was profiled via traditional culturing method as well as metagenomic approach by sequencing the 16S rRNA V3 hyper-variable region on Illumina Miseq Platform (Illumina, Inc., San Diego, CA). Read More

    The role of tedizolid in skin and soft tissue infections.
    Curr Opin Infect Dis 2018 Apr;31(2):131-140
    Department of Medicine, School of Medicine, Universidad Complutense de Madrid.
    Purpose Of Review: Tedizolid is a second-generation oxazolidinone with activity against Gram-positive bacteria, including MRSA isolates resistant to linezolid. Pivotal clinical trials showed that tedizolid at 200 mg once-daily for 6 days is not inferior to linezolid 600 mg twice daily for 10 days in patients with SSTI. The comparison of adverse events is favorable to tedizolid under the circumstances of the clinical trials. Read More

    Efficacy of Aloe vera/ Plantago major gel in Diabetic Foot Ulcer: a randomized double-blind clinical trial.
    Curr Drug Discov Technol 2018 01 14. Epub 2018 Jan 14.
    Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad. Iran.
    Background: Diabetic foot ulcer (DFU) is one of the most common complications of diabetic patients. Mostly, non-healing DFU leads to infection, gangrene, amputation and even death. High costs and poor healing of the wounds need a new treatment such as alternative medicine. Read More

    Genomic Insights into Biofilm-Forming SK460 Isolated from a Chronic Diabetic Ulcer Patient.
    Genome Announc 2018 Jan 11;6(2). Epub 2018 Jan 11.
    Cholera and Biofilm Research Lab, Rajiv Gandhi Centre for Biotechnology, Trivandrum, Kerala, India
    is recognized as one of the leading pathogens causing nosocomial infections. Here we report a draft genome sequence of SK460, isolated from a chronic diabetic foot ulcer patient. This strain exhibits various biofilm-associated genes, virulence genes, and antibiotic-resistance genes related to aminoglycoside, macrolide, and tetracycline resistance. Read More

    The Effect of Cryopreserved Human Placental Tissues on Biofilm Formation of Wound-Associated Pathogens.
    J Funct Biomater 2018 Jan 8;9(1). Epub 2018 Jan 8.
    New Jersey Center for Biomaterials, Rutgers University, 145 Bevier Rd., Piscataway, NJ 08854, USA.
    Biofilm, a community of bacteria, is tolerant to antimicrobial agents and ubiquitous in chronic wounds. In a chronic DFU (Diabetic Foot Ulcers) clinical trial, the use of a human cryopreserved viable amniotic membrane (CVAM) resulted in a high rate of wound closure and reduction of wound-related infections. Our previous study demonstrated that CVAM possesses intrinsic antimicrobial activity against a spectrum of wound-associated bacteria under planktonic culture conditions. Read More

    Neutralizing Alpha-Toxin Accelerates Healing of Staphylococcus aureus-Infected Wounds in Nondiabetic and Diabetic Mice.
    Antimicrob Agents Chemother 2018 Mar 23;62(3). Epub 2018 Feb 23.
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    wound infections delay healing and result in invasive complications such as osteomyelitis, especially in the setting of diabetic foot ulcers. In preclinical animal models of skin infection, antibody neutralization of alpha-toxin (AT), an -secreted pore-forming cytolytic toxin, reduces disease severity by inhibiting skin necrosis and restoring effective host immune responses. However, whether therapeutic neutralization of alpha-toxin is effective against -infected wounds is unclear. Read More

    1 OF 72