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    3518 results match your criteria Diabetic Foot Infections

    1 OF 71

    Metataxonomic approach to decipher the polymicrobial burden in diabetic foot ulcer and its biofilm mode of infection.
    Int Wound J 2018 Jan 22. Epub 2018 Jan 22.
    Cholera and Biofilm Research Lab, Rajiv Gandhi Centre for Biotechnology, Trivandrum, Kerala, India.
    Chronic diabetic foot is a global burden affecting millions of people, and the chronicity of an ulcer is directly linked to the diverse bacterial burden and its biofilm mode of infection. The bacterial diversity of 100 chronic diabetic ulcer samples was profiled via traditional culturing method as well as metagenomic approach by sequencing the 16S rRNA V3 hyper-variable region on Illumina Miseq Platform (Illumina, Inc., San Diego, CA). Read More

    The role of tedizolid in skin and soft tissue infections.
    Curr Opin Infect Dis 2018 Jan 15. Epub 2018 Jan 15.
    Department of Medicine, School of Medicine, Universidad Complutense de Madrid.
    Purpose Of Review: Tedizolid is a second-generation oxazolidinone with activity against Gram-positive bacteria, including MRSA isolates resistant to linezolid. Pivotal clinical trials showed that tedizolid at 200 mg once-daily for 6 days is not inferior to linezolid 600 mg twice daily for 10 days in patients with SSTI. The comparison of adverse events is favorable to tedizolid under the circumstances of the clinical trials. Read More

    Efficacy of Aloe vera/ Plantago major gel in Diabetic Foot Ulcer: a randomized double-blind clinical trial.
    Curr Drug Discov Technol 2018 Jan 14. Epub 2018 Jan 14.
    Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad. Iran.
    Background: Diabetic foot ulcer (DFU) is one of the most common complications of diabetic patients. Mostly, non-healing DFU leads to infection, gangrene, amputation and even death. High costs and poor healing of the wounds need a new treatment such as alternative medicine. Read More

    Genomic Insights into Biofilm-Forming Enterococcus faecalis SK460 Isolated from a Chronic Diabetic Ulcer Patient.
    Genome Announc 2018 Jan 11;6(2). Epub 2018 Jan 11.
    Cholera and Biofilm Research Lab, Rajiv Gandhi Centre for Biotechnology, Trivandrum, Kerala, India
    Enterococcus faecalis is recognized as one of the leading pathogens causing nosocomial infections. Here we report a draft genome sequence of Enterococcus faecalis SK460, isolated from a chronic diabetic foot ulcer patient. This strain exhibits various biofilm-associated genes, virulence genes, and antibiotic-resistance genes related to aminoglycoside, macrolide, and tetracycline resistance. Read More

    The Effect of Cryopreserved Human Placental Tissues on Biofilm Formation of Wound-Associated Pathogens.
    J Funct Biomater 2018 Jan 8;9(1). Epub 2018 Jan 8.
    New Jersey Center for Biomaterials, Rutgers University, 145 Bevier Rd., Piscataway, NJ 08854, USA.
    Biofilm, a community of bacteria, is tolerant to antimicrobial agents and ubiquitous in chronic wounds. In a chronic DFU (Diabetic Foot Ulcers) clinical trial, the use of a human cryopreserved viable amniotic membrane (CVAM) resulted in a high rate of wound closure and reduction of wound-related infections. Our previous study demonstrated that CVAM possesses intrinsic antimicrobial activity against a spectrum of wound-associated bacteria under planktonic culture conditions. Read More

    Neutralizing α-toxin accelerates healing of Staphylococcus aureus-infected wounds in normal and diabetic mice.
    Antimicrob Agents Chemother 2018 Jan 8. Epub 2018 Jan 8.
    Department of Dermatology, Department of Orthopaedic, Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Staphylococcus aureus wound infections delay healing and result in invasive complications such as osteomyelitis, especially in the setting of diabetic foot ulcers. In preclinical animal models of S. aureus skin infection, antibody neutralization of α-toxin (AT), a S. Read More

    An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds.
    Value Health 2018 Jan 19;21(1):27-32. Epub 2017 Sep 19.
    Integra Lifesciences, Plainsboro, NJ, USA.
    Objective: The aim of this study was to determine the cost of chronic wound care for Medicare beneficiaries in aggregate, by wound type and by setting.

    Methods: This retrospective analysis of the Medicare 5% Limited Data Set for calendar year 2014 included beneficiaries who experienced episodes of care for one or more of the following: arterial ulcers, chronic ulcers, diabetic foot ulcers, diabetic infections, pressure ulcers, skin disorders, skin infections, surgical wounds, surgical infections, traumatic wounds, venous ulcers, or venous infections. The main outcomes were the prevalence of each wound type, Medicare expenditure for each wound type and aggregate, and expenditure by type of service. Read More

    Assessing the Effect of Piperacillin/Tazobactam on Hematological Parameters in Patients Admitted with Moderate or Severe Foot Infections.
    Diabetes Ther 2018 Jan 4. Epub 2018 Jan 4.
    Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK.
    Introduction: Piperacillin/tazobactam is a commonly used antibiotic for the empirical treatment of severe diabetic foot infections. One of the most feared complications of this drug is the development of pancytopenia. The aim of this study was to determine whether the use of piperacillin/tazobactam caused any hematological changes in patients admitted with severe diabetes-related foot infections from a specialist multidisciplinary foot clinic. Read More

    Clinical Guidelines for the Antibiotic Treatment for Community-Acquired Skin and Soft Tissue Infection.
    Infect Chemother 2017 Dec;49(4):301-325
    Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea.
    Skin and soft tissue infection (SSTI) is common and important infectious disease. This work represents an update to 2012 Korean guideline for SSTI. The present guideline was developed by the adaptation method. Read More

    Microbiological profile and clinical characteristics of diabetic foot infection in northern China: a retrospective multicentre survey in the Beijing area.
    J Med Microbiol 2018 Jan 2. Epub 2018 Jan 2.
    3​Department of Endocrinology, Peking University First Hospital, Beijing, PR China.
    Purpose: We aimed to define the microbiological characteristics of diabetic foot infection in patients in the Beijing area and to explore the demographic and clinical factors correlated with pathogen distribution.

    Methodology: As part of a retrospective multicentre surveillance program conducted in eight hospitals in Beijing 2010-2014, we recruited all inpatients for whom bacterial culture had been performed. Demographic, clinical, laboratory and surgery data were obtained from medical records. Read More

    Single stage treatment of diabetic calcaneal osteomyelitis with an absorbable gentamicin-loaded calcium sulphate/hydroxyapatite biocomposite: The Silo technique.
    Foot (Edinb) 2017 Nov 23;34:40-44. Epub 2017 Nov 23.
    Trauma and Orthopaedics Department, Wythenshawe Hospital, Manchester, United Kingdom. Electronic address:
    Background: Chronic osteomyelitis necessities appropriate infected bone and soft tissue excision. The authors describe the Silo surgical technique for the treatment of calcaneal osteomyelitis using a new antibiotic-loaded absorbable calcium sulphate/hydroxyapatite biocomposite.

    Methods: The Silo method involves debridement of the dead bone and local delivery of antibiotic in drilled tunnels using the biocomposite. Read More

    Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer): an international, multicentre, double-blind, randomised, controlled trial.
    Lancet Diabetes Endocrinol 2017 Dec 20. Epub 2017 Dec 20.
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy.
    Background: Diabetic foot ulcers are serious and challenging wounds associated with high risk of infection and lower-limb amputation. Ulcers are deemed neuroischaemic if peripheral neuropathy and peripheral artery disease are both present. No satisfactory treatment for neuroischaemic ulcers currently exists, and no evidence supports one particular dressing. Read More

    Emerging Trends in Therapeutic Algorithm of Chronic Wound Healers: Recent Advances in Drug Delivery Systems, Concepts-to-Clinical Application and Future Prospects.
    Crit Rev Ther Drug Carrier Syst 2017 ;34(5):387-452
    School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan, Hubei Province, 430070, P.R. China.
    Chronic wounds which include diabetic foot ulcer (DFU), pressure ulcer, and arterial or venous ulcers compel a significant burden to the patients, healthcare providers, and the healthcare system. Chronic wounds are characterized by an excessive persistent inflammatory phase, prolonged infection, and the failure of defense cells to respond to environmental stimuli. Unlike acute wounds, chronic nonhealing wounds pose a substantial challenge to conventional wound dressings, and the development of novel and advanced wound healing modalities is needed. Read More

    Risk Factors for Infection with Pseudomonas aeruginosa in Diabetic Foot Infections.
    J Am Podiatr Med Assoc 2017 Nov;107(6):483-489
    Background: Selecting empirical therapy for a diabetic foot infection (DFI) requires knowing how likely infection with Pseudomonas aeruginosa is in a particular patient. We designed this study to define the risk factors associated with P aeruginosa in DFI.

    Methods: We performed a preplanned microbiological subanalysis of data from a study assessing the effects of treatment with intralesional epidermal growth factor for diabetic foot wounds in patients in Turkey between January 1, 2012, and December 31, 2013. Read More

    Reversible Secondary Osteolysis in Diabetic Foot Infection.
    J Am Podiatr Med Assoc 2017 Nov;107(6):538-540
    Osteolysis, caused by active resorption of bone matrix by osteoclasts, can be primary or can develop secondary to a variety of disease processes. An elevated level of inflammatory cytokines in the local milieu and increased blood flow secondary to infection or autonomic neuropathy stimulate the osteoclasts and cause bone loss in the diabetic foot. Charcot's neuroarthropathy and osteomyelitis are well-known foot complications of diabetes, and secondary osteolysis has largely been underappreciated and, hence, underreported. Read More

    The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification system correlates with cost of care for diabetic foot ulcers treated in a multidisciplinary setting.
    J Vasc Surg 2017 Dec 13. Epub 2017 Dec 13.
    Diabetic Foot and Wound Service, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Md; Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Md; Center for Surgical Trials and Outcomes Research, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Md. Electronic address:
    Objective: We have previously demonstrated that the Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification correlates with wound healing time in patients with diabetic foot ulcers (DFUs) treated in a multidisciplinary setting. Our aim was to assess whether the charges and costs associated with DFU care increase with higher WIfI stages.

    Methods: All patients presenting to our multidisciplinary diabetic limb preservation service from June 2012 to June 2016 were enrolled in a prospective database. Read More

    Diabetes and chronic kidney disease: an increasingly common multi-morbid disease in need of a paradigm shift in care.
    Diabet Med 2017 Dec 16. Epub 2017 Dec 16.
    East and North Herts Institute of Diabetes and Endocrinology (ENHIDE), Howlands Clinic, QEII Hospital, Welwyn Garden City, UK.
    Diabetes is considered the commonest cause of end-stage renal disease. The increasing incidence of obesity and an ageing population, together, will lead to a greater number of people with diabetes associated with chronic kidney disease that could either be secondary to diabetic nephropathy or of different aetiology. Ageing and obesity influence approaches to the management of diabetes and accurate assessment of kidney disease. Read More

    Diabetic foot ulcer management in clinical practice in the UK: costs and outcomes.
    Int Wound J 2017 Dec 15. Epub 2017 Dec 15.
    Bradford Teaching Hospitals NHS Foundation Trust and University of Bradford, Bradford, UK.
    The aim of this study was to estimate the patterns of care and annual levels of health care resource use attributable to managing diabetic foot ulcers (DFUs) in clinical practice by the UK's National Health Service (NHS), and the associated costs of patient management. This was a retrospective cohort analysis of the records of 130 patients with a newly diagnosed DFU in The Health Improvement Network (THIN) database. Patients' characteristics, wound-related health outcomes and health care resource use were quantified, and the total NHS cost of patient management was estimated at 2015-2016 prices. Read More

    Inpatient Management of Diabetic Foot Infections: A Review of the Guidelines for Hospitalists.
    J Hosp Med 2017 12 20;12(12):994-1000. Epub 2017 Sep 20.
    Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Diabetic foot infections (DFIs) are common and represent the leading cause for hospitalization among diabetic complications. Without proper management, DFIs may lead to amputation, which is associated with a decreased quality of life and increased mortality. However, there is currently significant variation in the management of DFIs, and many providers fail to perform critical prevention and assessment measures. Read More

    Cellular versus acellular grafts for diabetic foot ulcers: altering the protocol to improve recruitment to a comparative efficacy trial.
    Cutis 2017 Nov;100(5):E18-E21
    University of California Davis, Department of Dermatology, 3301 C St, Ste 1400, Sacramento, CA 95816, USA.
    Diabetic foot ulcers (DFUs) have a substantial impact on public health. The standard of care (SOC) for DFUs consists of a multidisciplinary approach involving glycemic control, wound care with debridement of necrotic tissue, application of a moist dressing, infection control, use of off-loading devices, and patient education. New therapeutic devices aim to target the extracellular matrix (ECM) that is impaired in DFU; however, there is insufficient data on the effectiveness of such therapies along with lack of evidence on their long-term effectiveness. Read More

    Knowledge of the Warning Signs of Foot Ulcer Deterioration Among Patients With Diabetes.
    J Nurs Res 2017 Dec 7. Epub 2017 Dec 7.
    PhD, RN, Associate Professor, School of Nursing, College of Medicine, Chang Gung University, and Associate Research Fellow, Department of General Surgery, Chang Gung Memorial Hospital.
    Background: Seeking treatment in a timely manner may prevent lower limb amputation subsequent to diabetic foot ulcers. Knowledge regarding the warning signs is one important factor that is related to the timely treatment seeking of patients with diabetic foot ulcers. However, there is no previous research on which aspects of such knowledge that patients with diabetes are lacking. Read More

    Modern management of diabetic foot osteomyelitis. The when, how and why of conservative approaches.
    Expert Rev Anti Infect Ther 2018 Jan 19;16(1):35-50. Epub 2017 Dec 19.
    b Department of Medicine , University of Washington School of Medicine , Seattle , WA , USA.
    Introduction: Diabetic foot osteomyelitis (DFO) has long been considered a complex infection that is both difficult to diagnose and treat, and is associated with a high rate of relapse and limb loss. Areas covered: DFO can usually be diagnosed by a combination of clinical evaluation, serum inflammatory markers and plain X-ray. When the results of these procedures are negative or contradictory, advanced imaging tests or bone biopsy may be necessary. Read More

    Genome sequencing and analysis of the first spontaneous Nanosilver resistant bacterium Proteus mirabilis strain SCDR1.
    Antimicrob Resist Infect Control 2017 23;6:119. Epub 2017 Nov 23.
    Genetics Department, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia.
    Background: P. mirabilis is a common uropathogenic bacterium that can cause major complications in patients with long-standing indwelling catheters or patients with urinary tract anomalies. In addition, P. Read More

    Evidence based review of literature on detriments to healing of diabetic foot ulcers.
    Foot Ankle Surg 2017 Dec 23;23(4):215-224. Epub 2016 Apr 23.
    Dalhousie University, Queen Elizabeth II Health Sciences Center Halifax Infirmary (Suite 4867), 1796 Summer Street, Halifax, Nova Scotia B3H3A7, Canada. Electronic address:
    Background: Diabetes mellitus places a substantial burden on society worldwide. Diabetic foot ulcers are a challenging problem for clinicians. Seven generally accepted detriments to healing of diabetic foot ulcers were identified: infection, glycaemic control, vascular supply, smoking, nutrition, deformity and offloading. Read More

    [Pathogen analysis in patients with diabetic foot osteomyelitis using 16S rRNA high-throughput sequencing].
    Nan Fang Yi Ke Da Xue Xue Bao 2017 Nov;37(11):1448-1455
    Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. E-mail:
    Objective: To analyze the characteristics of pathogenic microorganisms in the infected bone tissues in patients with diabetic foot osteomyelitis (DFO) using 16S rRNA high-throughput sequencing to facilitate rapid and accurate detection of pathogens and effective infection control.

    Methods: Between September, 2016 and April, 2017, 16 patients with DFO were admitted in our department and infected bone specimens were obtained during debridement. The pathogenic microorganisms in the specimens were identified using both 16S rRNA high-throughput sequencing and automatic blood culture analyzer, and the characteristics of the microflora were analyzed based on 16S rRNA sequencing data in comparison with the results of blood culture. Read More

    Deformity and Clinical Outcomes Following Operative Correction of Charcot Foot: A New Classification With Implications for Treatment.
    Foot Ankle Int 2017 Nov 1:1071100717742371. Epub 2017 Nov 1.
    1 Loyola University Health System, Maywood, IL, USA.
    Background: The historic treatment of Charcot foot arthropathy has been immobilization during the active phase of the disease process, followed by accommodative bracing of the acquired deformity. Evidence derived from modern patient-reported outcomes investigations has convinced many surgeons to attempt operative correction of the acquired deformity with a goal of improving quality of life.

    Methods: Over a 12-year period, 214 patients (9 bilateral) underwent reconstruction of the acquired deformity associated with midtarsal Charcot foot arthropathy. Read More

    Evaluation of short exposure times of antimicrobial wound solutions against microbial biofilms: from in vitro to in vivo.
    J Antimicrob Chemother 2017 Nov 18. Epub 2017 Nov 18.
    Surgical Infection Research Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.
    Objectives: Test the performance of topical antimicrobial wound solutions against microbial biofilms using in vitro, ex vivo and in vivo model systems at clinically relevant exposure times.

    Methods: Topical antimicrobial wound solutions were tested under three different conditions: (in vitro) 4% w/v Melaleuca oil, polyhexamethylene biguanide, chlorhexidine, povidone iodine and hypochlorous acid were tested at short duration exposure times for 15 min against 3 day mature biofilms of Staphylococcus aureus and Pseudomonas aeruginosa; (ex vivo) hypochlorous acid was tested in a porcine skin explant model with 12 cycles of 10 min exposure, over 24 h, against 3 day mature P. aeruginosa biofilms; and (in vivo) 4% w/v Melaleuca oil was applied for 15 min exposure, daily, for 7 days, in 10 patients with chronic non-healing diabetic foot ulcers complicated by biofilm. Read More

    Epidemiology of diabetic foot infections in a reference tertiary hospital in India.
    Braz J Microbiol 2017 Nov 1. Epub 2017 Nov 1.
    Department of Microbiology, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600113, Tamil Nadu, India.
    Introduction: The present study attempts to examine the microbial profile and antibiotic susceptibility of diabetic foot infections in the intensive care unit of a tertiary referral centre for diabetic foot. As part of the study, we also attempted to find the prevalence of blaNDM-like gene among carbapenem-resistant gram negative infections.

    Methodology: A prospective study of 261 patients with diabetic foot infections was performed during the period between January 2014 and June 2014. Read More

    Amnion: The Ideal Scaffold for Treating Full-Thickness Wounds of the Lower Extremity.
    Clin Podiatr Med Surg 2018 Jan 23;35(1):1-9. Epub 2017 Oct 23.
    Dartmouth-Hitchcock, Foot and Ankle/Podiatry, 25 South River Road, Bedford, NH 03110, USA. Electronic address:
    Amnion and amniotic tissue has been studied for more than 100 years in the treatment of acute and chronic wounds. Recent studies have focused on the use of amnion tissue in the management of full-thickness diabetic wounds, particularly of the lower extremities. With new harvesting, processing, and distribution technologies, amnion is increasingly available in treating these wounds. Read More

    Evaluation of major and minor lower extremity amputation in diabetic foot patients
    Turk J Med Sci 2017 08 23;47(4):1109-1116. Epub 2017 Aug 23.
    Background/aim: We evaluated the existing risk factors with clinical results in patients who underwent major and minor amputation of the lower extremity as a result of diabetic foot ulcers (DFUs). Materials and methods: We retrospectively studied 107 patients who had undergone lower extremity amputation. The patients were divided into minor (Group 1, n = 75) and major (Group 2, n = 32) amputation groups. Read More

    Intralesional epidermal growth factor therapy fordiabetic foot ulcers: an evaluation of 15 cases
    Turk J Med Sci 2017 11 13;47(5):1500-1504. Epub 2017 Nov 13.
    Background/aim: Intralesional recombinant epidermal growth factor (EGF) is a new treatment approach for diabetic foot ulcer, approved in 2006. EGF therapy is given as an adjunct to the standard treatment regimen of antibiotics, surgery, and hyperbaric oxygen. EGF accelerates the healing of diabetic foot ulcers and reduces healing time. Read More

    Growth factors for diabetic foot ulcers: mixed treatment comparison analysis of randomized clinical trials.
    Br J Clin Pharmacol 2017 Nov 17. Epub 2017 Nov 17.
    Department of Oral Health, College of Medicine, Nursing and Health Sciences, Fiji National University, Suva, Fiji.
    Aims: Topical growth factors accelerate wound healing in patients with diabetic foot ulcers (DFU). Due to the absence of head-to-head comparisons, we carried out Bayesian network meta-analysis to compare the efficacy and safety of growth factors.

    Methods: Using an appropriate search strategy, randomized controlled trials on topical growth factors compared with standard of care in patients with DFU, were included. Read More

    A Series of 210 Peripheral Arterial Disease Below-Knee Amputations and Predictors for Subsequent Above-Knee Amputations.
    Ann Vasc Dis 2017 Sep;10(3)
    Vascular Surgery Service, Department of General Surgery, Tan Tock Seng Hospital, Singapore.
    Objective: To review patient characteristics and outcomes after peripheral arterial disease (PAD)-related below-knee amputation (BKA), and identify risk factors predicting subsequent above-knee amputation (AKA). Materials and Methods: A retrospective study of 210 BKAs between May 2008 and December 2015. Results: The mean age of the study population was 66 years. Read More

    Antimicrobial Efficacy of Penicillium amestolkiae elv609 Extract Treated Cotton Fabric for Diabetic Wound Care.
    Mycobiology 2017 Sep 30;45(3):178-183. Epub 2017 Sep 30.
    Universiti Kuala Lumpur, Malaysian Institute of Chemical and Bioengineering Technology, 78000 Alor Gajah, Melaka, Malaysia.
    Diabetes mellitus is a chronic disorder which affects millions of population worldwide. Global estimates published in 2010 reported the world diabetic prevalence as 6.4%, affecting 285 million adults. Read More

    Efficacy of intravenous tigecycline in patients with Acinetobacter complex infections: results from 14 Phase III and Phase IV clinical trials.
    Infect Drug Resist 2017 3;10:401-417. Epub 2017 Nov 3.
    Pfizer Inc, Collegeville, PA, USA.
    Background: Acinetobacter infections, especially multidrug-resistant (MDR) Acinetobacter infections, are a global health problem. This study aimed to describe clinical outcomes in patients with confirmed Acinetobacter spp. isolates who were treated with tigecycline in randomized clinical trials. Read More

    Ciprofloxacin-loaded calcium alginate wafers prepared by freeze-drying technique for potential healing of chronic diabetic foot ulcers.
    Drug Deliv Transl Res 2017 Nov 13. Epub 2017 Nov 13.
    Department of Pharmaceutical, Chemical & Environmental Sciences, Faculty of Engineering and Science, University of Greenwich, Medway, Central Ave. Chatham Maritime, Kent, ME4 4TB, UK.
    Calcium alginate (CA) wafer dressings were prepared by lyophilization of hydrogels to deliver ciprofloxacin (CIP) directly to the wound site of infected diabetic foot ulcers (DFUs). The dressings were physically characterized by scanning electron microscopy (SEM), texture analysis (for mechanical and in vitro adhesion properties), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). Further, functional properties essential for wound healing, i. Read More

    A diabetic foot ulcer treated with hydrogel and hyperbaric oxygen therapy: a case study.
    J Wound Care 2017 Nov;26(11):692-695
    Lecturer, Universidade Luterana do Brasil, Rio Grande, Rio Grande do Sul, Brazil.
    This study reports on the case of an elderly patient, with diabetes, and a bullous wound on the left big toe that led to an amputation of the first and second left toes. The amputation was because of deep injury as it was not able to heal with a conventional treatment. After completing the normal treatment and the removal of a bacterial infection in the lesion, the patient underwent a treatment that was based on a hydrogel gel (0. Read More

    Topical oxygen therapy promotes the healing of chronic diabetic foot ulcers: a pilot study.
    J Wound Care 2017 Nov;26(11):652-660
    Consultant Vascular Surgeon, St George's Vascular Unit, St George's Healthcare NHS Trust, Tooting, London, UK.
    Objective: Interventions that can heal or reduce diabetic foot ulcer (DFU) size may reduce the incidence of infection and amputation, and reduce associated social and economic costs. Many chronic wounds exhibit a degree of hypoxia and this leads to a reduction in healing processes including cell division and differentiation, angiogenesis, infection prevention, and collagen production. The aim of this pilot study was to assess the effects of a device supplying continuous oxygen ambulatory therapy on healing in chronic DFUs. Read More

    Tibiotalocalcaneal Arthrodesis With the Hindfoot Arthrodesis Nail: A Prospective Consecutive Series From a Single Institution.
    J Foot Ankle Surg 2018 Jan - Feb;57(1):23-30. Epub 2017 Nov 9.
    Consultant, Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore.
    Tibiotalocalcaneal arthrodesis (TTCA) is a salvage procedure. We report a series of 20 patients who underwent TTCA using an intramedullary nail. Of the 20 patients, 7 (35%) had diabetes mellitus. Read More

    Medial forefoot fillet flap for primary closure of transmetatarsal amputation: A series of four cases.
    Foot (Edinb) 2017 Dec 29;33:53-56. Epub 2017 Jun 29.
    Department of Orthopedic Surgery, Rabin Medical Center, 39th Jabutinski St. Petach Tikva 49100, Affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address:
    Amputation of the forefoot is a salvage procedure for several forefoot acute or chronic infection. A good, sensate and durable skin cover is important for quicker and better rehabilitation. The use of filleted flaps (or "spare parts technique") has been published in the past as a creative technique. Read More

    Compassionate Use of Bacteriophage Therapy for Foot Ulcer Treatment as an Effective Step for Moving Toward Clinical Trials.
    Methods Mol Biol 2018 ;1693:159-170
    VA Northern California, Muir Road, Martinez, CA, 94553, USA.
    We here present detailed descriptions of successful treatment of a series of diabetic toe ulcers using the Eliava BioPreparations' commercial preparation of the very well-studied anti-staphylococcal bacteriophage Sb-1. This chapter outlines what we feel is an appropriate mechanism to speed movement toward full-scale clinical trials with bacteriophage use to treat wound infections and to help address the crisis in antibiotic resistance. Read More

    Bacteriophage Treatment of Infected Diabetic Foot Ulcers.
    Methods Mol Biol 2018 ;1693:151-158
    Institute of Chemical Biology and Fundamental Medicine SB RAS, Laboratory of Molecular Microbiology, Lavrentiev Ave. 8, Novosibirsk, 630090, Russian Federation.
    Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of infected ulcers is complicated by formation of microbial biofilms , which are often heterogeneous and resistant to antibiotics. Read More

    Antibiotic Resistance in Diabetic Foot Soft Tissue Infections: A Series From Greece.
    Int J Low Extrem Wounds 2017 Dec 7;16(4):255-259. Epub 2017 Nov 7.
    1 Democritus University of Thrace, Alexandroupolis, Greece.
    Diabetic foot infections are a common and serious problem for all health systems worldwide. The aim of this study was to examine the resistance to antibiotics of microorganisms isolated from infected soft tissues of diabetic foot ulcers, using tissue cultures. We included 113 consecutive patients (70 men, 43 women) with a mean age of 66. Read More

    Minimally Invasive Distal Metatarsal Diaphyseal Osteotomy (DMDO) for Chronic Plantar Diabetic Foot Ulcers.
    Foot Ankle Int 2018 Jan 7;39(1):83-92. Epub 2017 Nov 7.
    1 Orthopaedic Clinic, Department of Surgery, Oncology and Gastroenterology DiSCOG, University of Padua, Padova, Italy.
    Background: The aims of this prospective study were first to evaluate the safety and effectiveness of minimally invasive distal metatarsal diaphyseal osteotomies (DMDOs) for treating a consecutive series of diabetic patients with chronic plantar diabetic foot ulcers (CPDFUs) and second to assess their clinical-functional and radiographic outcomes.

    Methods: A consecutive series of patients affected by diabetes mellitus with CPDFUs, not responsive to previous nonoperative management, underwent DMDO. The CPDFUs were evaluated using the University of Texas Diabetic Wound Classification System (UTDWC). Read More

    Comparative Assessment of Tedizolid Pharmacokinetics and Tissue Penetration between Diabetic Patients with Wound Infections and Healthy Volunteers via In Vivo Microdialysis.
    Antimicrob Agents Chemother 2018 Jan 21;62(1). Epub 2017 Dec 21.
    Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA
    Herein, we present pharmacokinetic and tissue penetration data for oral tedizolid in hospitalized patients with diabetic foot infections (DFI) compared with healthy volunteers. Participants received oral tedizolid phosphate 200 mg every 24 h for 3 doses to achieve steady state. A microdialysis catheter was inserted into the subcutaneous tissue near the margin of the wound for patients or into thigh tissue of volunteers. Read More

    Viability of permanent PMMA spacer with combined free fasciocutaneous tissue transfer for failed charcot reconstruction: A 38 month prospective case report.
    Int J Surg Case Rep 2017 4;41:174-179. Epub 2017 Oct 4.
    Department of Plastic Surgery, MedStar Georgetown University Hospital, Washington, DC, USA. Electronic address:
    Introduction: Charcot Neuroarthropathy is a complex lower extremity pathology which predisposes the afflicted limb to ulcerations, osteomyelitis, and risk of major amputation. Charcot Neuroarthropathy often requires osseous reconstruction, which can be complicated with osteomyelitis and hardware infection. When soft tissue and osseous deficits must be concomitantly addressed, the use of PMMA spacers can be combined with free tissue transfers. Read More

    Multiple limb salvage attempts for diabetic foot infections: is it worth it?
    Bone Joint J 2017 Nov;99-B(11):1502-1507
    National University Hospital, 1E Kent Ridge Road, Singapore.
    Aims: Limb salvage for diabetic foot infections often require multiple procedures. Some patients will eventually end up with below knee amputation (BKA) when all limb salvage attempts fail. We seek to study the patients' ability to return to normal life, functional status, prosthesis usage and perspectives on multiple limb salvage procedures that culminated in BKA to review if they would undertake a similar path if their situation was repeated. Read More

    Updating the Diabetic Foot Treatment Algorithm: Recommendations on Treatment Using Advanced Medicine and Therapies.
    Wounds 2017 Oct 20. Epub 2017 Oct 20.
    Dr. William M. School College of Podiatric Medicine, Rosalind Franklin University of Medicine and Science, Center for Lower Extremity Ambulatory Research (CLEAR), North Chicago, IL.
    Objective: Since the last diabetic foot ulcer (DFU) treatment algorithm was published in 2002, new options for diagnostic testing and treatments have been developed. This study seeks to update the DFU treatment algorithm to include new options available in diagnostic testing and treatment.

    Materials And Methods: A computerized literature search of peer-reviewed articles published between January 2003 and January 2016 was conducted using MEDLINE (PubMed), EMBASE, and the Cochrane Library. Read More

    Prognosis of the infected diabetic foot ulcer: a 12-month prospective observational study.
    Diabet Med 2018 Jan 20;35(1):78-88. Epub 2017 Nov 20.
    Schoool of Healthcare, University of Leeds, Leeds, UK.
    Aims: To determine clinical outcomes and explore prognostic factors related to ulcer healing in people with a clinically infected diabetic foot ulcer.

    Methods: This multicentre, prospective, observational study reviewed participants' data at 12 months after culture of a diabetic foot ulcer requiring antibiotic therapy. From participants' notes, we obtained information on the incidence of wound healing, ulcer recurrence, lower extremity amputation, lower extremity revascularization and death. Read More

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