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    3437 results match your criteria Diabetic Foot Infections

    1 OF 69

    Growth factors in the pathogenesis of diabetic foot ulcers.
    Front Biosci (Landmark Ed) 2018 Jan 1;23:310-317. Epub 2018 Jan 1.
    Institute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, China.
    Foot ulcers affect 15% of patients with diabetes, resulting in a great health burden. The occurrence and development of diabetic foot ulcers is associated with neuropathy, peripheral arterial disease, and infection. Several growth factors are involved in these processes, including epidermal growth factor, vascular endothelial growth factor, transforming growth factor-beta, fibroblast growth factor, and erythropoietin, which could promote wound healing of patients with diabetes. Read More

    Clinical and surgical characteristics of infected diabetic foot ulcers in a tertiary hospital of Mexico.
    Diabet Foot Ankle 2017 6;8(1):1367210. Epub 2017 Sep 6.
    Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
    Background: The objective of this study was to determine the clinical and surgical characteristics of diabetic foot ulcers in a tertiary level hospital in Mexico. Methods: We performed a longitudinal, descriptive study from July, 2012 to August, 2015 on a sample composed of 100 patients with type 2 diabetes mellitus and infected diabetic foot ulcers. We analyzed socio-demographic variables, comorbidities, characteristics of ulcers, and the applied treatment. Read More

    Procalcitonin levels and other biochemical parameters in patients with or without diabetic foot complications.
    J Res Med Sci 2017 16;22:95. Epub 2017 Aug 16.
    National Center of Diabetes, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq.
    Background: Diagnosis of infection in diabetic foot ulcer (DFU) is not always simple. The analytic precision of procalcitonin (PCT) was evaluated to clarify the use of PCT for distinguish the presence of infection in DFU in comparison to other inflammatory markers.

    Materials And Methods: This study comprised 88 subjects distributed into four groups: 16 nondiabetic healthy subjects (group control), 17 patients with type 2 diabetes mellitus without foot Complication (group DM), 25 patients with noninfected diabetic foot (group NIDF), and 30 patients with infected diabetic foot (group IDF). Read More

    Pharmacokinetics and Tissue Penetration of Ceftolozane/Tazobactam in Diabetic Patients with Lower Limb Infections and Healthy Adult Volunteers.
    Antimicrob Agents Chemother 2017 Sep 11. Epub 2017 Sep 11.
    Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA
    Ceftolozane/tazobactam displays potent activity against gram-negative bacteria that can cause diabetic foot infections (DFI), making it an attractive treatment option when few alternatives exist. The pharmacokinetics and tissue penetration of ceftolozane/tazobactam 1.5g q8h in patients (n=10) with DFI were compared with healthy volunteers (n=6) using in vivo microdialysis. Read More

    Diabetic foot infection: Antibiotic therapy and good practice recommendations.
    Int J Clin Pract 2017 Sep 11. Epub 2017 Sep 11.
    Ninewells Hospital, Dundee, UK.
    Background: Healthcare events related to diabetic foot disease carry a burden of morbidity, mortality and economic cost. Prompt identification of clinical infection with appropriate tissue sampling limits use of broad spectrum empirical antibiotics and improves antibiotic stewardship. Staphylococcus aureus remains the commonest infecting organism and high-dose flucloxacillin remains the empirical antibiotic of choice for antibiotic naïve patients. Read More

    Severity of drug resistance and co-existence of Enterococcus faecalis in diabetic foot ulcer infections.
    Folia Microbiol (Praha) 2017 Sep 9. Epub 2017 Sep 9.
    Department of Biotechnology, School of Life Sciences, Manipal University, Manipal, 576104, India.
    The genes encoding aminoglycoside resistance in Enterococcus faecalis may promote collateral aminoglycoside resistance in polymicrobial wounds. We studied a total of 100 diabetic foot ulcer samples for infection and found 60 samples to be polymicrobial, 5 to be monomicrobial, and 35 samples to be culture negative. A total of 65 E. Read More

    S Afr J Surg 2017 Jun;55(2):67
    Edenvale General Hospital, Johannesburg.
    Background: Infection is a common cause for the admission of surgical patients who were initially seen and managed at the primary health care level. Delay to care significantly increases the health care burden of surgical sepsis on affected individuals, the health system and society.

    Method: A prospective descriptive study was performed by means of a confidential questionnaire presented to qualifying patients between February 2014 and October 2016. Read More

    Importance of education in the prevention of diabetic foot syndrome.
    Neuro Endocrinol Lett 2017 Aug 5;38(4):255-256. Epub 2017 Aug 5.
    Faculty of Health and Social Studies, South Bohemian University, Ceske Budejovice, Czech Republic.
    To the Editor, Diabetic foot syndrome (DFS) is defined by the WHO as ulceration or destruction of foot tissue in diabetic patients associated with neuropathy, with different degrees of the disease existing and frequently also with infection. The statistics are frightening: more than million amputations are annually carried out worldwide due to diabetic foot (Foster and Lauver 2014) and these amputations represent as far as 70% of all non-traumatic amputations. In 2013, 861 647 patients were treated for diabetes mellitus in Czech Republic, including 44 657 patients with diabetic foot syndrome and 11 168 patients had to experience the amputation of lower limb due to this condition. Read More

    Clinical and microbiological profile of diabetic foot ulcer patients in a tertiary care hospital.
    Diabetes Metab Syndr 2017 Aug 26. Epub 2017 Aug 26.
    Department of Medicine, Yenepoya University, Deralakatte, Mangalore, India. Electronic address:
    Aim: To evaluate the clinical and microbiological profile of diabetic foot ulcer patients admitted to a tertiary care hospital.

    Methodology: This study recruited 120 diabetic foot ulcer patients of all grade. Their medical records were evaluated retrospectively. Read More

    Application of white blood cell SPECT/CT to predict remission after a 6 or 12 week course of antibiotic treatment for diabetic foot osteomyelitis.
    Diabetologia 2017 Sep 2. Epub 2017 Sep 2.
    Hospices Civils de Lyon, Service de Médecine Nucléaire, Centre Hospitalier Lyon-Sud, Pierre Bénite, France.
    Aims/hypothesis: Diabetic foot osteomyelitis is a major risk factor for amputation. Medical treatment allows remission in 53-82% of cases. However, the optimal duration of antibiotic therapy remains controversial as a validated marker of osteomyelitis remission is lacking. Read More

    The Relationship Between Osteomyelitis Complication and Drug-Resistant Infection Risk in Diabetic Foot Ulcer: A Meta-analysis.
    Int J Low Extrem Wounds 2017 Sep 1;16(3):183-190. Epub 2017 Sep 1.
    1 School of Nursing, Nantong University, Nantong, Jiangsu, People's Republic of China.
    In this study, we aimed to investigate the relationship between osteomyelitis complications and drug-resistant infection risk in diabetic foot ulcer. Searches of MEDLINE and ISI databases were performed for the studies. Odds ratios (ORs) for drug-resistant infection incidence were calculated for diabetic foot ulcer patients with or without osteomyelitis complications. Read More

    The role of natural antimicrobial peptides during infection and chronic inflammation.
    Antonie Van Leeuwenhoek 2017 Aug 30. Epub 2017 Aug 30.
    College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, No. 90, Hualan Street, Xinxiang, 453003, People's Republic of China.
    Natural antimicrobial peptides (AMPs), a family of small polypeptides that are produced by constitutive or inducible expression in organisms, are integral components of the host innate immune system. In addition to their broad-spectrum antibacterial activity, natural AMPs also have many biological activities against fungi, viruses and parasites. Natural AMPs exert multiple immunomodulatory roles that may predominate under physiological conditions where they lose their microbicidal properties in serum and tissue environments. Read More

    J Med Liban 2016 Jul-Sep;64(3):164-7
    Background: Soft tissue defects in the foot and ankle region are challenging conditions particularly in diabetic patients. We evaluated the reliability of the sural flap in treating such defects among a diabetic population.

    Material And Methods: This is a continuous retrospective series of 14 patients with type 2 diabetes treated with an ipsilateral sural flap for soft tissue defects around the rear foot (11 cases) and over the malleolar areas (3 cases). Read More

    Empirical Antibiotic Treatment in Diabetic Foot Infection: A Study Focusing on the Culture and Antibiotic Sensitivity in a Population From Southern China.
    Int J Low Extrem Wounds 2017 Sep 24;16(3):173-182. Epub 2017 Aug 24.
    1 Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
    Diabetic foot and subsequent diabetic ulcer infections are the most devastating complication of diabetes. This study was conducted to explore the bacterial spectrum, sensitivity of microbials, and analysis of the empirical antibiotic regimens in our health center. The study included patients with diabetic foot ulcer infection (DFI) seen from 2009 to 2014. Read More

    Patients With Diabetic Foot Disease Fear Major Lower-Extremity Amputation More Than Death.
    Foot Ankle Spec 2017 Feb 1:1938640017694722. Epub 2017 Feb 1.
    Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas (DKW).
    Background: The aim of this study was to identify the most-feared complications of diabetes mellitus (DM), comparing those with diabetic foot pathology with those without diabetic foot pathology.

    Methods: We determined the frequency of patients ranking major lower-extremity amputation (LEA) as their greatest fear in comparison to blindness, death, diabetic foot infection (DFI), or end-stage renal disease (ESRD) requiring dialysis. We further categorized the study group patients (N = 207) by their pathology such as diabetic foot ulcer (DFU), Charcot neuroarthropathy, foot infection, or acute neuropathic fractures and dislocations. Read More

    Inflammatory markers as risk factors for infection with multidrug-resistant microbes in diabetic foot subjects.
    Foot (Edinb) 2017 May 3;32:44-48. Epub 2017 May 3.
    Rajiv Gandhi Centre for Diabetes and Endocrinology, J.N. Medical College, Aligarh Muslim University, Aligarh, India; Department of Medicine, J.N. Medical College, Aligarh Muslim University, Aligarh, India; Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, India. Electronic address:
    Background: Diabetic foot ulcers (DFUs), a dreadful microvascular complication of diabetes is responsible for substantial increase in morbidity and mortality. Infection, not a cause, but a consequence in DFUs that accounts for minor or major limb loss. The current study aimed to evaluate the microbial etiology of infected diabetic foot ulcers in northern tertiary care hospital, assessment of risk factors and role of inflammatory markers involved in colonization of multidrug-resistant organisms (MDROs) and their impact on the outcome. Read More

    [Anatomic stabilization of chronic lateral instability of the ankle : Gold technique].
    Oper Orthop Traumatol 2017 Aug 1. Epub 2017 Aug 1.
    Abteilung für Sportorthopädie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, München, Deutschland.
    Objectives: Anatomical reconstruction of the lateral ligament complex in the ankle.

    Indications: Chronic lateral ankle instability.

    Contraindications: Severe osteoarthritis, obesity, hindfoot varus, general contraindications (infection, circulatory disorders, diabetic foot syndrome). Read More

    Predictors of Lower Extremity Amputation and Reamputation in the Diabetic Foot.
    J Foot Ankle Surg 2017 Jul 29. Epub 2017 Jul 29.
    Assistant Professor, Department of Orthopedics and Traumatology, Konya Necmettin Erbakan University Meram School of Medicine, Konya, Turkey.
    In the present study, we aimed to identify the comorbidities that would be predictive of requiring lower extremity amputation or reamputation for diabetic foot wounds. We performed a retrospective review of 132 consecutive patients who had undergone lower extremity amputations (110 patients) or reamputations (22 patients) for diabetic wounds from January 2013 to March 2016. We used multivariate logistic regression to calculate the odds ratios (ORs) for amputation and reamputation for various comorbidities. Read More

    Previous Atorvastatin Treatment and Risk of Diabetic Foot Infection in Adult Patients: A Case-control Study.
    Wounds 2017 Jul 27;29(7):196-201. Epub 2017 Apr 27.
    Objective: In addition to their lipid-lowering abilities, statins have anti-inflammatory and immunomodulatory properties. Increasing recent evidence suggests the possible role of pretreatment with statins in preventing or decreasing morbidity and mortality from infection. Diabetic foot infection (DFI) is a common complication of diabetes mellitus. Read More

    A longitudinal study of the diabetic skin and wound microbiome.
    PeerJ 2017 20;5:e3543. Epub 2017 Jul 20.
    The i3 institute, University of Technology Sydney, Sydney, New South Wales, Australia.
    Background: Type II diabetes is a chronic health condition which is associated with skin conditions including chronic foot ulcers and an increased incidence of skin infections. The skin microbiome is thought to play important roles in skin defence and immune functioning. Diabetes affects the skin environment, and this may perturb skin microbiome with possible implications for skin infections and wound healing. Read More

    Potential of circulatory procalcitonin as a biomarker reflecting inflammation among South Indian diabetic foot ulcers.
    J Vasc Surg 2017 Jul 20. Epub 2017 Jul 20.
    SRM Research Institute, SRM University, Chennai, Tamilnadu, India. Electronic address:
    Objective: Diabetic foot ulcer (DFU), the major complication associated with diabetes mellitus, has been shown to precede amputation in up to 90% of cases. Recent data reveal that procalcitonin (PCT) is a valid marker for the diagnosis of bacterial infections compared with traditional markers like white blood cell count, C-reactive protein levels, and erythrocyte sedimentation rate in DFU patients. Furthermore, cytokines are proposed to act as modulators and mediators for the expression and release of PCT into the circulation. Read More

    Levels of wound calprotectin and other inflammatory biomarkers aid in deciding which patients with a diabetic foot ulcer need antibiotic therapy (INDUCE study).
    Diabet Med 2017 Jul 22. Epub 2017 Jul 22.
    Division of Infection and Immunity, Cardiff University, Cardiff, UK.
    Aims: Deciding if a diabetic foot ulcer is infected in a community setting is challenging without validated point-of-care tests. Four inflammatory biomarkers were investigated to develop a composite algorithm for mildly infected diabetic foot ulcers: venous white cell count, C-reactive protein (CRP) and procalcitonin, and a novel wound exudate calprotectin assay. Calprotectin is a marker of neutrophilic inflammation. Read More

    Detection of Osteomyelitis in the Diabetic Foot by Imaging Techniques: A Systematic Review and Meta-analysis Comparing MRI, White Blood Cell Scintigraphy, and FDG-PET.
    Diabetes Care 2017 Aug;40(8):1111-1120
    Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
    Objective: Diagnosing bone infection in the diabetic foot is challenging and often requires several diagnostic procedures, including advanced imaging. We compared the diagnostic performances of MRI, radiolabeled white blood cell (WBC) scintigraphy (either with (99m)Tc-hexamethylpropyleneamineoxime [HMPAO] or (111)In-oxine), and [(18)F]fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET)/computed tomography.

    Research Design And Methods: We searched Medline and Embase as of August 2016 for studies of diagnostic tests on patients known or suspected to have diabetes and a foot infection. Read More

    Risk factors for amputation in patients with diabetic foot infection: a prospective study.
    Int Wound J 2017 Jul 19. Epub 2017 Jul 19.
    Department of Dermatology, Ege University Medical Faculty, Izmir, Turkey.
    There is a variety of diagnostic and therapeutic algorithms for diabetic foot infections (DFIs). Some of them are too difficult to be applied in routine clinical approach. In the routine clinical approach, it is necessary to find new risk factors and end up with a quick and easy assessment of DFIs. Read More

    Bacteriology Of Diabetic Foot In Tertiary Care Hospital; Frequency, Antibiotic Susceptibility And Risk Factors.
    J Ayub Med Coll Abbottabad 2017 Apr-Jun;29(2):234-240
    Department of Medicine, Rawal Institute of Health Sciences, Islamabad, Pakistan.
    Background: Diabetic foot being one of the frequent and disabling complications of diabetes. In view of widespread regional variation in causative organisms and antimicrobial susceptibility, the current study aimed to determine frequency of causative organisms, their antimicrobial susceptibility and associated risk factors.

    Methods: This descriptive cross-sectional study was conducted in 6 months' duration at dept. Read More

    Quantitative Evaluation of Rehabilitation Effect on Peripheral Circulation of Diabetic Foot.
    IEEE J Biomed Health Inform 2017 Jul 13. Epub 2017 Jul 13.
    Diabetics may encounter different foot problems, which easily lead to infection, ulcers, and increased risk of amputation due to nerve or vascular injury. In order to reduce the risk of amputation, Buerger's exercise is one of the frequently used rehabilitation to improve the blood circulation in the lower limbs. However, it is difficult to evaluate the rehabilitation efficiency of Buerger's exercise objectively. Read More

    Frequency Of Common Bacteria And Their Antibiotic Sensitivity Pattern In Diabetics Presenting With Foot Ulcer.
    J Ayub Med Coll Abbottabad 2016 Jul-Sep;28(3):528-533
    Department of Medicine, Khyber Teaching Hospital, Peshawar, Pakistan.
    Background: Foot ulcers are one of the most important complications of diabetes mellitus and often lead to lower limb amputation. Diabetic foot ulcers are susceptible to infection. The objective of this study was to determine the frequency of common bacteria infecting these ulcers and their antibiotic sensitivity pattern. Read More

    Amputation predictors in diabetic foot ulcers treated with hyperbaric oxygen.
    J Wound Care 2017 Jul;26(7):361-366
    Department of Underwater and Hyperbaric Medicine, Faculty of Meram Medicine, Necmettin Erbakan University, Konya, Turkey.
    Objective: Although hyperbaric oxygen therapy (HBOT) has long been used for diabetic foot ulcers (DFUs), its effectiveness is still controversial. The aim of this study was to investigate the efficacy of HBOT in the management of DFUs and identify amputation predictors.

    Method: Patients with chronic DFUs (Wanger grade 2-5) were included in the study, which took place between January 2010 and December 2012. Read More

    Midterm Outcomes From a Pilot Study of Percutaneous Deep Vein Arterialization for the Treatment of No-Option Critical Limb Ischemia.
    J Endovasc Ther 2017 Oct 12;24(5):619-626. Epub 2017 Jul 12.
    9 Vascular Surgery Unit, Department of Surgery, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Purpose: To report the initial clinical experience with percutaneous deep vein arterialization (PDVA) to treat critical limb ischemia (CLI) via the creation of an arteriovenous fistula.

    Methods: Seven patients (median age 85 years; 5 women) with CLI and no traditional endovascular or surgical revascularization options (no-option CLI) were recruited in a pilot study to determine the safety of PDVA. All patients were diabetic; 4 had Rutherford category 6 ischemia. Read More

    Advanced MR Imaging Techniques for Differentiation of Neuropathic Arthropathy and Osteomyelitis in the Diabetic Foot.
    Radiographics 2017 Jul-Aug;37(4):1161-1180
    From the MRI Section, Department of Radiology, SERCOSA, Health Time, Calle Carmelo Torres 2, 23007 Jaén, Spain (T.M.N., A.L.A.); Department of Radiology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio (A.L.A.); Department of Radiology, NYU Langone Medical Center, New York, NY (L.S.B.); MRI Section, Department of Radiology, DADISA, Health Time, Cádiz, Spain (M.G.C.); MRI Section, Department of Radiology, RESSALTA, Health Time, Córdoba, Spain (J.B.C.); and Department of Radiology, Clínica Girona, Catalan Institute of Health (IDI), University of Girona, Girona, Spain (J.C.V.).
    Diagnosis and treatment of foot disease in patients with diabetes is a common clinical-radiologic challenge, particularly the differentiation of neuropathic arthropathy from osteomyelitis. Conventional clinical tests and imaging techniques have limited accuracy for evaluation of the diabetic foot. The introduction of morphologic magnetic resonance (MR) imaging in these patients has provided a qualitative leap in diagnosis. Read More

    Total Contact Cast System to Heal Diabetic Foot Ulcers.
    Surg Technol Int 2017 Jul;30:71-76
    Surgical Services, Circleville Foot & Ankle and Berger Health System, Circleville, Ohio.
    Off-loadinga diabetic foot ulcer is a cornerstone of quality wound care for diabetic patients to allow cellular growth in the wound bed. While total contact casts (TCC) have been described as the gold standard for off-loading the wound, the complexity of application and the time commitment for both application and drying have discouraged health professionals from using them. This retrospective case series, conducted in a podiatric practice, evaluated using a TCC system that helps address the three components in which guidelines should be addressed when caring for a diabetic foot: V - vascular management, I - infection management and prevention, and P - pressure relief. Read More

    End-Stage Renal Disease Negatively Affects Physical Quality of Life in Patients With Diabetic Foot Complications.
    Int J Low Extrem Wounds 2017 Jun 4;16(2):135-142. Epub 2017 May 4.
    2 University of Texas Southwestern Medical Center, Dallas, TX, USA.
    The aim of this study was to evaluate the impact of end-stage renal disease (ESRD) on health-related quality of life (QOL) in patients with diabetic foot disease. We compared a group of 30 diabetic patients with ESRD requiring dialysis to a group of 60 diabetic patients without ESRD. Both groups consisted of patients with active diabetic foot disease (ulcer, Charcot, infection) and were matched with regard to age and gender. Read More

    Bacterial Prevalence and Antibiotic Resistance in Clinical Isolates of Diabetic Foot Ulcers in the Northeast of Tamaulipas, Mexico.
    Int J Low Extrem Wounds 2017 Jun 26;16(2):129-134. Epub 2017 Apr 26.
    1 Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa, Tamaulipas, México.
    Diabetic foot ulcers (DFUs) are a serious and common problem in patients with diabetes mellitus and constitute one of the major causes of lower extremity amputation. The microbiological profile of DFUs depends on the acute or chronic character of the wound. Aerobic gram-positive cocci are the predominant organisms isolated from DFUs. Read More

    Does Everything That's Counted Count? Value of Inflammatory Markers for Following Therapy and Predicting Outcome in Diabetic Foot Infection.
    Int J Low Extrem Wounds 2017 Jun 9;16(2):104-107. Epub 2017 Apr 9.
    2 Baylor College of Medicine, Houston, TX, USA.
    To assess the severity of inflammation associated with diabetic foot infection (DFI), values of inflammatory markers such as white blood count (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and neutrophil to lymphocyte ratio (NLR) are often measured and tracked over time. It remains unclear if these markers can aid the clinician in the diagnosis and management of DFI, and ensure more rational use of antibiotics. Hospitalized adult patients (n = 379) with DFI were retrospectively assessed for abnormal inflammatory markers, correlation between values of inflammatory markers, and clinical diagnosis on initial admission and on last follow-up. Read More

    Expression and Influence of Matrix Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 and Vascular Endothelial Growth Factor in Diabetic Foot Ulcers.
    Int J Low Extrem Wounds 2017 Mar 8;16(1):6-13. Epub 2017 Mar 8.
    1 Wuhan Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei, China.
    A high matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 (MMP9/TIMP1) ratio is associated with poor ulcer healing, yet how the ratio of MMP9/TIMP1 changes in diabetic foot ulcers (DFUs) with infection and how these changes may affect wound healing remain unclear. Therefore, the objective of this investigation was to explore relationships among the MMP9/TIMP1 ratio, infection, and DFUs. After being informed of the details of this study, 32 patients signed consent forms. Read More

    Enterococci in orthopaedic infections: Who is at risk getting infected?
    J Infect 2017 Oct 1;75(4):309-314. Epub 2017 Jul 1.
    Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, University of Geneva, Switzerland; Service of Infectious Diseases, University of Geneva Hospitals and Faculty of Medicine, University of Geneva, Switzerland.
    Some orthopaedic patients might be at risk for enterococcal infections and might benefit from adapted perioperative prophylaxis.

    Methods: We performed a single-center cohort of adult patients with orthopaedic infections.

    Results: Among 2740 infection episodes, 665 surgeries (24%) involved osteosynthesis material, including total joint arthroplasties. Read More

    Recent advances in polymer-based wound dressings for the treatment of diabetic foot ulcer: an overview of state-of-the-art.
    Curr Drug Targets 2017 Jul 4. Epub 2017 Jul 4.
    Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Raiwind Road Lahore, Punjab. Pakistan.
    Diabetic foot ulcers (DFUs) are the chronic, non-healing complications of diabetic mellitus which compels a significant burden to the patients and the healthcare system. Peripheral vascular disease, diabetic neuropathy, and abnormal cellular and cytokine/chemokine activity are among the prime players which exacerbate the severity and prevent wound reapir. Unlike acute wounds, DFUs impose a substantial challenge to the conventional wound dressings and demand the development of novel and advanced wound healing modalities. Read More

    Next Generation DNA Sequencing of Tissues from Infected Diabetic Foot Ulcers.
    EBioMedicine 2017 Jul 27;21:142-149. Epub 2017 Jun 27.
    Surgical Infection Research Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.
    We used next generation DNA sequencing to profile the microbiome of infected Diabetic Foot Ulcers (DFUs). The microbiota was correlated to clinical parameters and treatment outcomes to determine if directed antimicrobial therapy based on conventional microbiological cultures are relevant based on genomic analysis. Patients≥18years presenting with a new Diabetic Foot Infection (DFI) who had not received topical or oral antimicrobials in the two weeks prior to presentation, were eligible for enrolment. Read More

    All-cause and cardiovascular mortality in a consecutive series of patients with diabetic foot osteomyelitis.
    Diabetes Res Clin Pract 2017 Sep 15;131:12-17. Epub 2017 Jun 15.
    Diabetology - Azienda Ospedaliero Universitaria Careggi, Italy.
    Background: Mortality in patients with type 2 diabetes and diabetic foot osteomyelitis (DFO) have been explored in few small studies with a short follow-up. Aim of the present study is to assess all-cause and cardiovascular mortality and predictors of mortality in a consecutive series of patients with DFO.

    Research Design And Methods: Patients with a diagnosis of DFO, attending the Diabetic Foot Unit of San Donato Hospital in Arezzo between January 1st, 2012 and December 31st, 2013, were included in this retrospective study. Read More

    Early Use of Ceftaroline Fosamil in the United States Veterans Health Care System.
    Drugs 2017 Aug;77(12):1345-1351
    Pharmacotherapy Division, College of Pharmacy, The University of Texas at Austin, San Antonio, TX, USA.
    Background: Ceftaroline fosamil is US Food and Drug Administration-approved for acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia, but it is not known how ceftaroline is being used in real-world settings or how adverse effects (AEs) and mortality compare to clinical trials.

    Objective: This study describes ceftaroline use, AEs, and mortality in US Veterans Health Administration (VHA) hospital patients.

    Methods: This phase IV, population-based, epidemiologic study analyzed patients ≥18 years old who received one or more ceftaroline doses within 14 days of admission to 69 VHA hospitals in 41 US states/territories from 1 October 2010 to 30 September 2014. Read More

    A Retrospective Review of Adverse Events Related to Diabetic Foot Ulcers.
    Ostomy Wound Manage 2017 Jun;63(6):30-33
    James A. Haley Veterans' Hospital, Tampa, FL.
    The risk of adverse events (AEs) such as infection and amputation related to diabetic foot ulcers (DFUs) has been studied, but less is known about rate of other AEs such as falls. As part of a quality improvement project, AEs in veterans with diabetes mellitus (DM) with and without a DFU were examined. Demographic data including ICD-9 codes, AEs, and comorbidities for all patients with a diagnosis of DM and/or DFU treated between 2009 and 2014 at the James A. Read More

    Platelet-Rich Fibrin Accelerates Skin Wound Healing in Diabetic Mice.
    Ann Plast Surg 2017 Sep;79(3):e15-e19
    From the *Department of Plastic and Reconstructive Surgery, PLA Hospital of No. 117, Hangzhou; and †Department of Plastic Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, People's Republic of China.
    Diabetic foot ulcers (DFUs) are associated with an increased risk of secondary infection and amputation. Platelet-rich fibrin (PRF), a platelet and leukocyte concentrate containing several cytokines and growth factors, is known to promote wound healing. However, the effect of PRF on diabetic wound healing has not been adequately investigated. Read More

    Clinical profile and outcome of diabetic foot ulcer, a view from tertiary care hospital in Semarang, Indonesia.
    Diabet Foot Ankle 2017 17;8(1):1312974. Epub 2017 May 17.
    Resident of Internal Medicine, Medical Faculty of Diponegoro University, Dr. Kariadi General Hospital, Semarang, Indonesia.
    Background: This study attempted to determine the disease burden in terms of clinical profile and outcome of diabetic foot ulcer (DFU) admissions at a tertiary care hospital in a developing country. Methods: In this descriptive study, the data were collected from the medical record of diabetic patients with foot ulcer who were treated in Dr. Kariadi General Hospital during a 3-year period. Read More

    Microscopy visualisation confirms multi-species biofilms are ubiquitous in diabetic foot ulcers.
    Int Wound J 2017 Jun 23. Epub 2017 Jun 23.
    Surgical Infection Research Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.
    Increasing evidence within the literature has identified the presence of biofilms in chronic wounds and proposed that they contribute to delayed wound healing. This research aimed to investigate the presence of biofilm in diabetic foot ulcers (DFUs) using microscopy and molecular approaches and define if these are predominantly mono- or multi-species. Secondary objectives were to correlate wound observations against microscopy results in ascertaining if clinical cues are useful in detecting wound biofilm. Read More

    [Surgical treatment of diabetic neuroosteoarthropathy (DNOAP) and its long-term results].
    Khirurgiia (Mosk) 2017(6):41-50
    Bryukhovetskaya Central Regional Hospital, Krasnodar Territory, Russia.
    Aim: To develop pathogenetically justified surgical treatment of diabetic neuroosteoarthropathy (DNOAP).

    Material And Methods: 52 patients were operated and long-term results were studied in 36 of them. 2 groups were assessed depending on completeness of surgical treatment including changed synovial structures removal. Read More

    Factors Predicting Length of Hospital Stay and Extended Care Facility Admission After Hindfoot Arthrodesis Procedures.
    J Foot Ankle Surg 2017 Jul - Aug;56(4):805-812
    Professor and Chair, Department of Orthopaedic Surgery, Sports Medicine and Rehabilitation, Boonshoft School of Medicine, Wright State University, Dayton, OH.
    Delayed identification of patients requiring admission to extended care facilities (ECFs) can lead to greater healthcare costs through an increased length of hospital stay (LOHS). Previous studies of hip and knee arthroplasty identified factors associated with a likely discharge to an ECF. These issues have not been extensively studied for major hindfoot procedures. Read More

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