3,607 results match your criteria Diabetic Foot Infections


Microbiological, Clinical and Radiological Aspects of Diabetic Foot Ulcers Infected with Methicillin-Resistant and -Sensitive .

Pathogens 2022 Jun 17;11(6). Epub 2022 Jun 17.

2nd Division of Radiology, Medical Faculty, Medical University of Gdansk, 80-214 Gdansk, Poland.

Diabetic foot ulcer (DFU) is one of the most common chronic complications of diabetes. This study aimed to assess the factors with an impact on the infection of diabetic foot ulcers by methicillin-resistant and to evaluate the influence of methicillin resistance on the frequency of osteitis (based on classic X-ray images). A total of 863 patients suffering from DFU were analyzed during the study period. Read More

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Debridement of diabetic foot ulcers: public health and clinical implications - a systematic review, meta-analysis, and meta-regression.

BMJ Surg Interv Health Technol 2022 30;4(1):e000081. Epub 2022 May 30.

Department of Allied Health Sciences, University of Connecticut, Storrs, Connecticut, USA.

Background: Diabetic foot ulceration (DFU) has devastating complications and a lifetime occurrence of 15%-34%. Debridement of DFU is regarded as an intervention that accelerates ulcer healing and may reduce complications including amputations, infections, and poor quality of life (QoL), which have serious public health and clinical implications. A systematic review (SR) of SRs and of randomized controlled trials (RCTs) with meta-analyses (MAs) on debridement of DFU that synthesizes all human experimental evidence is warranted. Read More

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Polyherbal formulation exerts wound healing, anti-inflammatory, angiogenic and antimicrobial properties: Potential role in the treatment of diabetic foot ulcers.

Saudi J Biol Sci 2022 Jul 1;29(7):103330. Epub 2022 Jun 1.

Natural Products for Neuroprotection and Anti-ageing Research Unit, Chulalongkorn University, Bangkok 10330, Thailand.

Diabetic foot ulcer (DFU) is a common and devastating complication in diabetic patients and is associated with an elevated risk of amputation and mortality. DFU remains a major therapeutic challenge due to poor understanding of its underlying pathogenesis. This complication is characterized by impaired wound healing; however, mechanisms causing this impairment are complicated and involve interactions between many different cell types and infections. Read More

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Fluorodeoxyglucose PET/Computed Tomography in Evaluation of Prosthetic Joints and Diabetic Foot: A Comparative Perspective with Other Functional Imaging Modalities.

PET Clin 2022 Jul;17(3):517-531

Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Infection imaging has been an important part of nuclear medicine practice. Infections in prosthetic joints and diabetic foot are associated with devastating complications, posing substantial challenge for both diagnosis and overall management. For many years, conventional nuclear medicine techniques have been used to frame a painful joint arthroplasty or diabetic foot infection. Read More

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The effectiveness of systemic antibiotics for osteomyelitis of the foot in adults with diabetes mellitus: a systematic review protocol.

J Foot Ankle Res 2022 Jun 17;15(1):48. Epub 2022 Jun 17.

Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.

Background: Osteomyelitis of the foot is a major complication of diabetes that can be limb and life threatening. Systemic antibiotic pharmacotherapy is often used first line to eradicate infection and allow restoration of devitalised bone. The aim is to conduct a systematic review of the effectiveness of systemic antibiotics on osteomyelitis of the foot in adults with diabetes mellitus. Read More

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Antibiotic-loaded Bone Cement Combined with Vacuum-assisted Closure Facilitating Wound Healing in Wagner 3-4 Diabetic Foot Ulcers.

Int J Low Extrem Wounds 2022 Jun 15:15347346221109045. Epub 2022 Jun 15.

Department of Vascular Surgery, 527527The Affiliated Qingdao Central Hospital of Qingdao University, Qingdao, Shandong, PR China.

This study explored the clinical effectiveness of antibiotic-loaded bone cement (ALBC) combined with vacuum-assisted closure (VAC) on the treatment of Wagner 3-4 diabetic foot ulcers (DFUs). This is a retrospective study, including 32 patients with Wagner 3-4 DFUs who had undergone treatment between August 2019 and June 2021. Patient age, sex, Hemoglobin A1c (HbA1c), body mass index (BMI), ankle brachial index (ABI), white blood cells (WBC), C-reactive protein (CRP) levels, comorbidities and wound closure methods were recorded. Read More

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Neuropathic ulcers in leprosy: clinical features, diagnosis and treatment.

J Wound Care 2022 Jun;31(Sup6):S32-S40

Leprosy Research Group, Colombian Institute of Tropical Medicine, CES University, Medellín, Colombia.

Leprosy is a neglected disease caused by and s, and is related to significant disabilities resulting from the neural damage generated by this mycobacteria. Neuropathic ulcers-lesions that can appear at the plantar and extra-plantar levels-are one such disability, and diagnosis requires an adequate dermatological, neurological and microbiological evaluation. The treatment of these lesions is based on a multidisciplinary approach that includes debridement of the necrotic tissue, controlling infections, reducing pressure areas, optimising blood flow, and nerve decompression. Read More

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Impact of COVID-19 on the surgical profile of vascular surgery patients at a tertiary hospital in Curitiba, Brazil.

J Vasc Bras 2022 23;21:e20220027. Epub 2022 May 23.

Hospital Santa Casa de Curitiba - HSCMC, Curitiba, PR, Brasil.

Background: During the COVID-19 pandemic, healthcare services reduced the number of elective procedures performed. Vascular surgery patients are a group at risk of contracting severe forms of the infection, but are also susceptible to complications of their underlying diseases if they do not receive routine care. It is therefore necessary to understand the direct and indirect impacts and consequences of the pandemic on vascular patients. Read More

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Australian guideline on management of diabetes-related foot infection: part of the 2021 Australian evidence-based guidelines for diabetes-related foot disease.

J Foot Ankle Res 2022 Jun 9;15(1):47. Epub 2022 Jun 9.

Infectious Diseases Department, Royal Perth Hospital, Perth, Australia.

Background: Diabetes-related foot infections cause substantial morbidity and mortality, both globally and in Australia. There is a need for up-to-date evidence-based guidelines to ensure optimal management of patients with diabetes-related foot infections. We aimed to identify and adapt high quality international guidelines to the Australian context to become the new Australian evidence-based guideline for people with a diabetes-related foot infection. Read More

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Diabetic foot infection caused by bacteria of the Burkholderia cepacia complex: report of an unusual case and a scoping literature review.

Rev Inst Med Trop Sao Paulo 2022 6;64:e36. Epub 2022 Jun 6.

Hospital Unimed Volta Redonda , Departamento de Cirurgia Vascular, Volta Redonda , Rio de Janeiro , Brazil.

Burkholderia cepacia complex (BCC) is group of widespread gram-negative bacillus organized in over 20 phylogenetically distinct bacterial species. According to previous studies, BCC species pathogens are widely reported in patients with cystic fibrosis (CF), but not in individuals with diabetes mellitus (DM). In this case report, a 42-year-old male patient with DM and a foot infection caused by BCC is presented. Read More

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Do patients with diabetic foot ulcer need booster dose of tetanus vaccine?

J Diabetes Metab Disord 2022 Jun 30;21(1):1023-1027. Epub 2022 Jan 30.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: Diabetic foot ulcer is a public health concern around the world. These wounds are prone to a variety of infections including that may lead to tetanus. The aim of this study was to evaluate the immunity status as a result of tetanus vaccination and other preventive measures in these patients. Read More

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A case of necrotizing fasciitis from a pedicure: when beauty centers become life-threatening.

Acta Biomed 2022 Jun 7;93(S1):e2022126. Epub 2022 Jun 7.

University of Siena.

Introduction: in a historical moment where there is an increasing use of beauty center, we report a case of necrotizing fasciitis occurred after a pedicure, with the aim of clarifying the safety of these aesthetic treatments.

Case Report: we discuss a case of left foot necrotizing fasciitis as consequence of removing a plantar callus. The patient is a 49 years old man; he is hypertensive, and diabetic not controlled. Read More

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Microbial Infection and Antibiotic Susceptibility of Diabetic Foot Ulcer in China: Literature Review.

Front Endocrinol (Lausanne) 2022 19;13:881659. Epub 2022 May 19.

Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.

Objective: To investigate the microbial spectrum isolated from foot ulcers among diabetic patients in China, which was conducted to help clinicians choose optimal antibiotics empirically.

Method: The PubMed, MEDLINE, Web of Science, China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), WanFang, and VIP databases were searched for studies published between 2015 to 2019, that report primary data on diabetic foot infection (DFI) and antibiotic susceptibility in China.

Result: A total of 63 articles about DFI and antibiotic susceptibility tests among diabetic patients in China were included. Read More

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Microbiota of diabetic foot infections in a University Hospital in Bogotá, Colombia.

Foot (Edinb) 2021 Sep 22;52:101867. Epub 2021 Sep 22.

Universidad de la Sabana, Hospital de la Samaritana, Carrera 8 #0-29 Sur, Santa Fé, Bogotá, Cundinamarca, Bogotá, Colombia. Electronic address:

The presence of infection in diabetic foot ulcers (DFU) is one of the main causes of lower limb amputation in the world. The presence of polymicrobial infections is usually the standard for isolation in such lesions, with Gram Positive (GP) germs being the main organisms involved, as is described in the global literature. However, some studies indicate a greater number of isolates with Gram Negative (GN) germs, reported mainly in the literature of Middle Eastern countries and in the tropics. Read More

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September 2021

Neutralizing Staphylococcus aureus Virulence with AZD6389, a Three mAb Combination, Accelerates Closure of a Diabetic Polymicrobial Wound.

mSphere 2022 Jun 1:e0013022. Epub 2022 Jun 1.

Early Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, Maryland, USA.

Nonhealing diabetic foot ulcers (DFU), a major complication of diabetes, are associated with high morbidity and mortality despite current standard of care. Since Staphylococcus aureus is the most common pathogen isolated from nonhealing and infected DFU, we hypothesized that S. aureus virulence factors would damage tissue, promote immune evasion and alter the microbiome, leading to bacterial persistence and delayed wound healing. Read More

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Pseudomonal Diabetic Foot Infections: Vive la Différence?

Mayo Clin Proc Innov Qual Outcomes 2022 Jun 23;6(3):250-256. Epub 2022 May 23.

Clinical Pathway for Diabetic Foot Infections, Geneva University Hospitals, Geneva, Switzerland.

Objective: To assess the outcomes of diabetic foot infections (DFIs) due to .

Patients And Methods: From April 24, 2013 to July 31, 2016, we analyzed data from patients prospectively enrolled in our clinical pathway of DFIs, comparing those with infection due to with those without infection due to .

Results: Overall, we assessed 1018 cases of DFIs: 392 with osteomyelitis and 626 with only soft tissue infections. Read More

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Towards Understanding the Lymph Node Response to Skin Infection with Saprophytic .

Biomedicines 2022 Apr 28;10(5). Epub 2022 Apr 28.

Department of Human Epigenetics, Mossakowski Medical Research Institute, 02-106 Warsaw, Poland.

In individuals with lymphedema, diabetic foot, or other diseases, infections with saprophytes are common. The response of major cell subpopulations in the draining lymph nodes to skin infection with was assessed using the rat model. After massive subepidermal infection, a cytometric evaluation showed an increase in cytotoxic and helper T lymphocytes and major subpopulations of the innate immune response. Read More

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The Emergence and Dissemination of Multidrug Resistant in Lebanon: Current Status and Challenges during the Economic Crisis.

Antibiotics (Basel) 2022 May 19;11(5). Epub 2022 May 19.

Center for Food Safety, Department of Food Science and Technology, University of Georgia, 1109 Experiment Street, Griffin, GA 30223-1797, USA.

is a common cause of healthcare-associated infections and chronic airway diseases in non-clinical settings. is intrinsically resistant to a variety of antimicrobials and has the ability to acquire resistance to others, causing increasingly recalcitrant infections and elevating public health concerns. We reviewed the literature on multidrug-resistant (MDR) isolated from humans (nosocomial and community-associated), animals, and the environment in Lebanon, a country that has been suffering from a surge in antimicrobial resistance (AMR). Read More

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Screening of Natural Molecules as Adjuvants to Topical Antibiotics to Treat from Diabetic Foot Ulcer Infections.

Antibiotics (Basel) 2022 May 4;11(5). Epub 2022 May 4.

LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal.

Diabetic foot ulcers (DFUs) are a common result of a complex secondary complication of diabetes . More than half of DFUs become infected due to frequent colonization with . The use of topical antibiotics is proposed, especially in combination with natural adjuvants, to minimize the negative impacts caused by generalized use of systemic antibiotics. Read More

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Moderate to Severe Soft Tissue Diabetic Foot Infections: A Randomized, Controlled, Pilot Trial of Post-Debridement Antibiotic Treatment for 10 versus 20 days.

Ann Surg 2021 Sep 15. Epub 2021 Sep 15.

Service of Infectious Diseases.

Background: The optimal duration of antibiotic therapy for soft-tissue infections of the diabetic foot (ST-DFI) remains unknown.

Objective: We determine if antibiotic therapy after debridement for a short (10 days), compared with a long (20 days), duration for ST-DFI results in similar rates of clinical remission and adverse events (AE).

Summary Background Data: The optimal duration of systemic antibiotic therapy, after successful debridement, for soft tissue infections of diabetic patients is unknown. Read More

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September 2021

efficacy of antibiotic loaded calcium sulfate beads (Stimulan Rapid Cure) against polymicrobial communities and individual bacterial strains derived from diabetic foot infections.

J Med Microbiol 2022 May;71(5)

Biosciences, University of Exeter, Stocker Road, Exeter, EX4 4QD, UK.

Diabetic foot infection (DFI) is the main reason for diabetes-related hospitalisation and is a major cause of diabetes-related amputation. DFIs are often complicated by ischaemia in the affected limb, the presence of polymicrobial biofilms and increasingly the occurrence of antibiotic resistant bacteria. Antibiotic loaded beads could inhibit the growth of polymicrobial DFI communities with differing compositions . Read More

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Worsening Glycemia Increases the Odds of Intermittent but Not Persistent Staphylococcus aureus Nasal Carriage in Two Cohorts of Mexican American Adults.

Microbiol Spectr 2022 May 18:e0000922. Epub 2022 May 18.

Center for Infectious Disease, Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center, Houston, Texas, USA.

Numerous host and environmental factors contribute to persistent and intermittent nasal Staphylococcus aureus carriage in humans. The effects of worsening glycemia on the odds of S. aureus intermittent and persistent nasal carriage was established in two cohorts from an adult Mexican American population living in Starr County, Texas. Read More

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C-reactive protein and diabetic foot ulcer infections: A meta-analysis.

J Tissue Viability 2022 May 7. Epub 2022 May 7.

School of Public Health, Nantong University, Nantong, China. Electronic address:

Background: Accurate identification of diabetic foot ulcer infection (IDFU) through inflammatory markers is still a challenge in clinical practice.

Objectives: This meta-analysis aims to investigates whether there is a significant indigenous association between CRP level and diabetic foot ulcer infection.

Methods: The studies on the diagnosis of IDFU by inflammatory marker C-reactive protein published before November 2021 in PubMed, Web of Science, Embase, and Cochrane Library were searched. Read More

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Microbiology of diabetic foot osteomyelitis - Is it geographically variable?

Foot (Edinb) 2021 Oct 27;52:101878. Epub 2021 Oct 27.

Department of Endocrinology, Silverline Hospital, Kochi, India.

Introduction: Diabetic foot osteomyelitis (DFO) is a dreaded complication as both diagnosis and treatment of the condition is laborious. However, for proper decision on antibiotics in medical management of DFO, accurate determination of microbes is necessary to narrow the spectrum of coverage and to reduce adverse effects of long-term administration of antibiotics. With differing pattern of use of antimicrobials and their resistance pattern in different countries, it is empirical to determine the microbiological characteristics of bone cultures in DFO from a referral institute in South India. Read More

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October 2021

Transcriptomic fingerprint of bacterial infection in lower extremity ulcers.

APMIS 2022 May 14. Epub 2022 May 14.

Department of Immunology and Microbiology, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark.

Clinicians and researchers utilize subjective, clinical classification systems to stratify lower extremity ulcer infections for treatment and research. The purpose of this study was to examine whether these clinical classifications are reflected in the ulcer's transcriptome. RNA sequencing (RNA-seq) was performed on biopsies from clinically infected lower extremity ulcers (n = 44). Read More

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Mortality Risk Associated with Diabetic Foot Complications in People with or without History of Diabetic Foot Hospitalizations.

J Clin Med 2022 Apr 27;11(9). Epub 2022 Apr 27.

Epidemiology Unit, Agenzia Regionale Sanità, 50141 Florence, Italy.

The aim of this study was to evaluate the risk of death after hospitalizations for diabetic foot (DF) complications, comparing two different cohorts of people with or without a prior history of DF hospitalizations across the years 2011 to 2018 in Tuscany, Italy. The DF complications were categorized by administrative source datasets such as: amputations (both major and minor), gangrene, ulcers, infections, Charcot and revascularizations. A further aim was to present the trend over time of the first ever incidents of diabetic foot hospitalizations in Tuscany. Read More

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Diabetic foot infections: how to investigate more efficiently? A retrospective study in a quaternary university center.

Insights Imaging 2022 May 10;13(1):88. Epub 2022 May 10.

Department of Diagnostic Radiology, Centre hospitalier de L'Université de Montréal, 1051 Rue Sanguinet, QC, H2X 3E4, Montreal, Canada.

Background: Diabetic foot infections are frequent and associated with substantial morbidity and substantial cost to the healthcare system. Up to 34% of diabetic patients will develop an ulcer potentially leading to osteomyelitis. Imaging plays a crucial role in the diagnostic process. Read More

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Prevalence, antimicrobial resistance profile, and characterization of multi-drug resistant bacteria from various infected wounds in North Egypt.

Saudi J Biol Sci 2022 Apr 15;29(4):2978-2988. Epub 2022 Jan 15.

Polymer Materials Research Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, P.O. Box: 21934, Alexandria, Egypt.

Multi-drug resistant (MDR) bacteria associated with wounds are extremely escalating. This study aims to survey different wounds in Alexandria hospitals, North Egypt, to explore the prevalence and characteristics of MDR bacteria for future utilization in antibacterial wound dressing designs. Among various bacterial isolates, we determined 22 MDR bacteria could resist different classes of antibiotics. Read More

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Plastic surgical repair of ulcer wounds of diabetic foot patients through systemic treatment and local infection control.

Ann Palliat Med 2022 Apr;11(4):1453-1461

Department of Plastic Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

Background: This study was to investigate the efficacy of plastic surgery in patients with diabetic foot (DF) ulcer who had systemic treatment and local infection control.

Methods: A total of 112 patients with DF were randomly divided into surgery group and drug treatment group according to treatment methods. Firstly, the pathogenic bacteria were isolated and cultured to explore the specific factors causing glycosuria foot ulcer. Read More

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Characteristics and Microbiological Profile of Patients with Diabetic Foot Infections in Kuantan, Pahang.

Malays Orthop J 2022 Mar;16(1):11-17

Department of Orthopaedics, Traumatology and Rehabilitation, International Islamic University Malaysia, Kuantan, Malaysia.

Introduction: The number of people suffering from diabetic foot infection (DFI) has increased precipitously over the years in Malaysia, owing to increased population, urbanisation, the surge of number of people with obesity and physical inactivity. As one of the most dreaded complications of diabetes mellitus, DFI is associated with high morbidity and mortality. We aim to study the microbiological profile of patients with DFI at a university hospital in Kuantan, Pahang. Read More

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