3,828 results match your criteria Diabetic Foot Infections


Calcaneal tuberosity fractures through prior Schantz pin sites in patients with diabetic neuropathy.

Foot (Edinb) 2019 Mar 2;39:96-99. Epub 2019 Mar 2.

Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, United States.

Schantz pin placement in the calcaneal tuberosity is a common procedure known to be complicated by pin site infections and nerve injuries. Fractures through Schantz pin sites has been reported mostly in diaphyseal bone. This case series highlights three patients with type 2 diabetes mellitus and diabetic neuropathy who were fixed in an external fixator frame with a pin through the calcaneal tuberosity. Read More

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http://dx.doi.org/10.1016/j.foot.2019.02.011DOI Listing

The Safety and Effectiveness of the Percutaneous Flexor Tenotomy in Healing Neuropathic Apical Toe Ulcers in the Outpatient Setting.

Foot Ankle Spec 2019 Apr 19:1938640019843314. Epub 2019 Apr 19.

Podiatry and Foot Ulcer/Charcot's Specialist Clinic, Austin Health, West Heidelberg, Victoria, Australia.

Percutaneous flexor tenotomy is a minimally invasive procedure that involves cutting one or both flexor digitorum tendons underneath the toe. It is an alternative to open surgical procedures performed in an operating theatre. This project is a prospective case series investigating the utility, effectiveness, and participant satisfaction of the percutaneous flexor tenotomy when performed in the outpatient setting. Read More

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http://dx.doi.org/10.1177/1938640019843314DOI Listing
April 2019
1 Read

Evaluation of various risk factors associated with multidrug-resistant organisms isolated from diabetic foot ulcer patients.

J Lab Physicians 2019 Jan-Mar;11(1):58-62

Department of Surgery, Government Medical College and Hospital, Chandigarh, India.

Aims: Diabetic foot ulcer is a dreaded complication of diabetes. Diabetic foot ulcer patients are often infected with multidrug resistant organism (MDRO) due to chronic course of the wound, inappropriate antibiotics treatment, frequent hospital admission, neuropathy, nephropathy, and peripheral vascular disease.

Materials And Methods: This prospective study was conducted in our 750 bedded hospital for a period of 6 months. Read More

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http://www.jlponline.org/text.asp?2019/11/1/58/254072
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http://dx.doi.org/10.4103/JLP.JLP_106_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437817PMC
April 2019
2 Reads

Multidisciplinary approach to scheduling surgery for diabetic foot: a case report.

BMC Musculoskelet Disord 2019 Apr 12;20(1):168. Epub 2019 Apr 12.

Department of Chinese Medicine Surgery, Beijing Hospital of Traditional Chinese Medicine, Affiliated to the Capital Medical University, No.23, Back Road of the Art Gallery, Dongcheng District, Beijing, 100010, China.

Background: The treatment of diabetic foot ulcers in this case is complex and multidisciplinary, and an interdisciplinary team is extremely beneficial.

Case Presentation: We performed the intervention on an old type 2 diabetes patient with poor health, whose left toes were severely necrotic. Surgery, including debridement and patella truncation, had positive effects on lower extremity circulation, infection control, cavity treatment, bone destruction, surgical debridement, recovery of foot function, and nursing. Read More

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https://bmcmusculoskeletdisord.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12891-019-2522-3DOI Listing
April 2019
2 Reads

Diabetic foot infections: a comprehensive overview.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):26-37

Diabetes Care Unit, Endocrinology, University Hospital "A. Gemelli", Catholic University of the Sacred Heart, Rome, Italy.

Diabetic foot ulcers (DFUs), a micro-vascular complication, are associated with a substantial increase in morbidity and mortality. DFUs are a complicated mixture of neuropathy, peripheral arterial diseases, foot deformities, and infections. Foot infections are frequent and potentially devastating complications. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17471DOI Listing
April 2019
1 Read

Retrograde dorsalis pedis angiosomal flow compromised by small puncture wound leading to transmetatarsal amputation.

Foot (Edinb) 2019 Feb 14;39:60-67. Epub 2019 Feb 14.

Foot and Ankle Surgery Resident, Dept. of Orthopedics, John Peter Smith Hospital, 1500 S. Main Street, Fort Worth, TX, 76104, United States.

Pedal puncture wounds can precipitate a variety of complications, often resulting from a delay in treatment. Although the risk of infection predominates, direct vascular insult and subsequent ischemia is a lesser reported complication of these injuries. Consequently, this may have morbid results, especially on a background of pre-existing peripheral vascular disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09582592183014
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http://dx.doi.org/10.1016/j.foot.2019.02.007DOI Listing
February 2019
2 Reads

Virulence factors and integrons are associated with MDR and XDR phenotypes in nosocomial strains of Pseudomonas aeruginosa in a Venezuelan university hospital.

Rev Inst Med Trop Sao Paulo 2019 4;61:e20. Epub 2019 Apr 4.

Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Queretaro, Mexico.

Multidrug resistance (MDR), virulence and transferable elements potentiate Pseudomonas aeruginosa's role as an opportunistic pathogen creating a high risk for public health. In this study, we evaluated the possible association of multidrug resistance, virulence factors and integrons with intrahospital P. aeruginosa strains isolated from patients at Cumana hospital, Venezuela. Read More

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http://dx.doi.org/10.1590/S1678-9946201961020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453424PMC
April 2019
1 Read

Advances in dermoepidermal skin substitutes for diabetic foot ulcers.

Curr Vasc Pharmacol 2019 Apr 8. Epub 2019 Apr 8.

Diabetes Centre-Diabetic Foot Clinic, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis. Greece.

Diabetic foot ulcers (DFUs) are one of the major complications of diabetes, representing a leading cause of hospitalisation and non-traumatic lower limb amputations. Multidisciplinary management, patient education, glucose control, debridement, off-loading, infection control, and adequate perfusion are the mainstays of standard care. Despite all these, at least 30% of DFUs fail to heal within 20 weeks. Read More

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http://dx.doi.org/10.2174/1570161117666190408170144DOI Listing
April 2019
5 Reads

Drug therapies and delivery mechanisms to treat perturbed skin wound healing.

Adv Drug Deliv Rev 2019 Apr 6. Epub 2019 Apr 6.

Lee Kong Chian School of Medicine, Nanyang Technological University, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore; Skin Research Institute Singapore, Clinical Sciences Building, 11 Mandalay Road, 308232, Singapore. Electronic address:

Acute wound healing is an orderly process of four overlapping events: haemostasis, inflammation, proliferation and remodelling. A drug delivery system with a temporal control of release could promote each of these events sequentially. However, acute wound healing normally proceeds very well in healthy individuals and there is little need to promote it. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0169409X193004
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http://dx.doi.org/10.1016/j.addr.2019.03.006DOI Listing
April 2019
2 Reads

Advancing pharmacotherapy for diabetic foot ulcers.

Expert Opin Pharmacother 2019 Apr 8:1-8. Epub 2019 Apr 8.

b Diabetes Centre-Diabetic Foot Clinic, Second Department of Internal Medicine , Democritus University of Thrace , Alexandroupolis , Greece.

Introduction: Standard treatment for diabetic foot ulcers (DFUs) includes off-loading, debridement, moisture balance, management of infection and peripheral arterial disease (PAD) as well as adequate glycemic control. The outcomes so far are unsatisfactory. Areas covered: Herein, the authors provide an outline of newer pharmacological agents for the management of DFUs and give their expert perspectives on future treatment strategies. Read More

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http://dx.doi.org/10.1080/14656566.2019.1598378DOI Listing
April 2019
1 Read

Antimicrobial stewardship opportunities among inpatients with diabetic foot infections: microbiology results from a tertiary hospital multidisciplinary unit.

Intern Med J 2019 Apr;49(4):533-536

Department of Infectious Diseases, Fiona Stanley Hospital, Perth, Western Australia, Australia.

Among 125 inpatients with diabetic foot infections managed by a multidisciplinary foot ulcer unit, knowledge of methicillin-resistant Staphylococcus aureus colonisation status assisted decision-making to prescribe appropriately or with-hold empiric anti-methicillin-resistant Staphylococcus aureus therapy. Despite adherence to national guidelines, apparent overuse of anti-pseudomonal therapy was frequent, providing potential antimicrobial stewardship opportunities. Read More

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http://dx.doi.org/10.1111/imj.14251DOI Listing
April 2019
1 Read

The prevalence of methicillin-resistant Staphylococcus aureus among diabetic patients: a meta-analysis.

Acta Diabetol 2019 Apr 6. Epub 2019 Apr 6.

Division of Infection and Pathway Medicine, Edinburgh Medical School, Biomedical Sciences, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, EH16 4SB, Edinburgh, UK.

Aims: Diabetic patients have multiple risk factors for colonisation with methicillin-resistant Staphylococcus aureus (MRSA), a nosocomial pathogen associated with significant morbidity and mortality. This meta-analysis was conducted to estimate the prevalence of MRSA among diabetic patients.

Methods: The MEDLINE, Embase, BIOSIS, and Web of Science databases were searched for studies published up to May 2018 that reported primary data on the prevalence of MRSA in 10 or more diabetic patients. Read More

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http://link.springer.com/10.1007/s00592-019-01301-0
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http://dx.doi.org/10.1007/s00592-019-01301-0DOI Listing
April 2019
7 Reads

Risk Factors for Amputation in Diabetic Foot Infections: A Meta-Analysis.

Diabetes Metab Res Rev 2019 Apr 5:e3165. Epub 2019 Apr 5.

Department of Biostatistics, Izmir Katip Celebi University School of Medicine, Izmir, Turkey.

Aims: Knowledge of risk factors is crucial to develop management and treatment protocols for the prevention of lower extremity amputation for patients with diabetic foot infections (DFI).

Materials And Methods: We searched the research literature for studies reporting risk factors for lower extremity amputation in patients with DFI. The main outcome variables included both minor and major amputations. Read More

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http://dx.doi.org/10.1002/dmrr.3165DOI Listing
April 2019
1 Read

Telemedicine Improves Chronic Ulcer Outcomes.

Authors:
Laura Bolton

Wounds 2019 Apr;31(4):114-116

Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.

Chronic ulcers greatly add to the clinical, economic, and patient burden on health care, increasing visits that challenge patients and strain overworked clinical centers. Telemedicine (TM) facilitates interprofessional collaboration and patient education and enables specialist bedside consults for clients without adding to their transfer and travel risks. Evidence supports improved postoperative monitoring, access to experts, and cost savings for TM-managed patients with acute or chronic wounds in a variety of settings. Read More

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April 2019
8 Reads

Laser therapy for onychomycosis in patients with diabetes at risk for foot ulcers: A randomised, quadruple-blind, sham controlled trial (LASER-1).

J Eur Acad Dermatol Venereol 2019 Mar 28. Epub 2019 Mar 28.

Medical Research Group Langerhans, Gerard Doustraat 36, 7731 MX, Ommen, the Netherlands.

Backgrounds: Patients with diabetes mellitus are at high risk for onychomycosis, which is related to development of foot ulcers.

Objective: The aim of this study was to evaluate the safety and efficacy of the treatment of onychomycosis with local laser therapy.

Methods: In a single-centre, randomised (1:1), quadruple blind, sham-controlled trial, patients with diabetes mellitus, at risk for developing diabetic foot ulcers (Sims classification score 1,2) and a clinical suspicion on onychomycosis were randomised to either 4 sessions neodymium- doped yttrium aluminium garnet (Nd-YAG) 1064nM laser or sham treatment. Read More

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http://dx.doi.org/10.1111/jdv.15601DOI Listing
March 2019
1 Read

The Significant Association between Polymicrobial Diabetic Foot Infection and Its Severity and Outcomes.

Malays J Med Sci 2019 Jan 28;26(1):107-114. Epub 2019 Feb 28.

Pathology Department, Hospital Raja Perempuan Zainab 2, 15586 Kota Bharu, Kelantan, Malaysia.

Background: Foot infection is a major complication of diabetes mellitus (DM) and its agents are usually polymicrobial. This study aims to describe the agent and determine the association between polymicrobial infections and the severity of diabetic foot infections (DFI) and their outcomes.

Methods: This retrospective cohort study was conducted during one year and it involved 104 patients. Read More

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http://dx.doi.org/10.21315/mjms2019.26.1.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419864PMC
January 2019
1 Read

Evidence of differential microbiomes in healing versus non-healing diabetic foot ulcers prior to and following foot salvage therapy.

J Orthop Res 2019 Mar 25. Epub 2019 Mar 25.

Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, New York.

Diabetic foot ulcers (DFU) contribute to 80% of lower extremity amputations. Although physicians currently rely on clinical signs along with non-specific biomarkers of infection, such as erythrocyte sedimentation rate and C-reactive protein, to diagnose and monitor DFU, there is no specific and sensitive measure available to monitor or prognosticate the success of foot salvage therapy (FST). To address this we performed a prospective, observational microbiome analysis to test the hypotheses that: (i) the initial microbiomes of healed versus non-healed DFU are distinct; (ii) the microbial load, diversity and presence of pathogenic organism of the DFU change in response to antibiotics treatment; and (iii) the changes in the DFU microbiome during treatment are prognostic of clinical outcome. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jor.24279
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http://dx.doi.org/10.1002/jor.24279DOI Listing
March 2019
10 Reads

Can we predict vascular status and culture result based through wound status in diabetic foot infection?

Medicine (Baltimore) 2019 Mar;98(12):e14892

Department of Plastic and Reconstructive Surgery, Medical School of Chonbuk National University.

Diabetic foot infection (DFI) should be treated by a multidisciplinary team to prevent amputation and morbid status. As physicians encountering DFI in outpatient clinic, a proper selection of antibiotic treatment and diagnostic approach for a vascular status is essential. We retrospectively investigated the patients with DFI from 2016 to 2017. Read More

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http://dx.doi.org/10.1097/MD.0000000000014892DOI Listing
March 2019
2 Reads

Intramedullary nail versus external fixator for ankle arthrodesis in Charcot neuroarthropathy: A meta-analysis of comparative studies.

J Orthop Surg (Hong Kong) 2019 May-Aug;27(2):2309499019836012

1 Department of Orthopedics, Lebanese American University Medical Center-Rizk Hospital, Achrafieh, Beirut, Lebanon.

Purpose:: Ankle Charcot neuroarthropathy presents a great challenge for treatment. While conservative treatments yield poor results, arthrodesis is considered the treatment of choice for unstable Charcot ankles. There are two methods used for ankle fusion: retrograde intramedullary nail (IMN) and external fixator (EF). Read More

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http://dx.doi.org/10.1177/2309499019836012DOI Listing
March 2019
3 Reads

Adjuvant antibiotic loaded bio composite in the management of diabetic foot osteomyelitis - A multicentre study.

Foot (Edinb) 2019 Jan 11;39:22-27. Epub 2019 Jan 11.

Trauma and Orthopaedics Department, Wythenshawe Hospital, Manchester University Foundation Trust, United Kingdom. Electronic address:

Background: Diabetic foot ulcers are associated with a high morbidity and are common cause of non-traumatic lower limb amputations. The effect of debridement and the use of an adjuvant local antibiotic carrier in the treatment of diabetic foot ulcers with osteomyelitis was evaluated.

Methods: A retrospective review of patients with diabetic foot ulceration and osteomyelitis treated by debridement with adjuvant local antibiotic was performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09582592183016
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http://dx.doi.org/10.1016/j.foot.2019.01.005DOI Listing
January 2019
8 Reads

The discovery and development of topical medicines for wound healing.

Expert Opin Drug Discov 2019 May 14;14(5):485-497. Epub 2019 Mar 14.

a Department of Medical Cell Biology , Uppsala University , Uppsala , Sweden.

Introduction: Chronic, nonhealing skin wounds claim >3% of the health-care budget in industrialized countries, and the incidence is rising. Currently, two parallel trends influence innovations within the field of wound healing: the need to reduce spread of antibiotic resistance and the emerging use of health economy and value-based models. Areas covered: This review focuses on the discovery of drug candidates and development of treatments aiming to enhance wound healing in the heterogeneous group of patients with nonhealing wounds. Read More

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https://www.tandfonline.com/doi/full/10.1080/17460441.2019.1
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http://dx.doi.org/10.1080/17460441.2019.1588879DOI Listing
May 2019
9 Reads

Diabetes and foot burns.

Ann Burns Fire Disasters 2018 Sep;31(3):181-184

Iran University of Medical Sciences.

The incidence of diabetes and diabetic foot burns is increasing worldwide. In the present study, we surveyed frequency, morbidity and mortality of diabetic foot burn patients in our centre. The study was a cross-sectional survey with one-year follow up of our adult diabetic patients with lower extremity burns. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367851PMC
September 2018
9 Reads

Hospitalists' Needs Assessment and Perceived Barriers in Wound Care Management: A Quality Improvement Project.

J Wound Ostomy Continence Nurs 2019 Mar/Apr;46(2):98-105

Cynthia A. Walker, MSN, RN, APRN-CNS, CWON, Interprofessional Practice & Patient Safety, Johns Hopkins Bayview Medical Center, Baltimore, Maryland. Alphonsa Rahman, DNP, APRN-CNS, CCRN, Interprofessional Practice & Patient Safety, Johns Hopkins Bayview Medical Center, Baltimore, Maryland. Trina L. Gipson-Jones, PhD, Hampton University, School of Nursing, Hampton, Virginia. Ché Matthew Harris, MD, MS, FACP, Department of General Internal Medicine, Johns Hopkins School of Medicine, Joint Appointment Johns Hopkins School of Nursing, Division of Hospital Medicine, Collaborative Inpatient Medicine Service, Baltimore, Maryland.

The purpose of this quality improvement project was to determine hospitalists' knowledge, practices, and perspectives related to management of pressure injuries and neuropathic/diabetic foot complications (having a foot ulcer or subsequent development of a foot infection because of a foot ulcer). We also sought to identify resources for and knowledge-based barriers to management of these wounds. This quality improvement effort targeted an interdisciplinary group of 55 hospitalists in internal medicine that consisted of 8 nurse practitioners, 10 physician assistants, and 38 physicians. Read More

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http://dx.doi.org/10.1097/WON.0000000000000512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407638PMC
March 2020
11 Reads

A Meta-Analysis of the Outcomes of Split-Thickness Skin Graft on Diabetic Leg and Foot Ulcers.

Int J Low Extrem Wounds 2019 Mar 7:1534734619832123. Epub 2019 Mar 7.

1 Lebanese American University Medical Center-Rizk Hospital, Beirut, Lebanon.

Diabetic lower limb ulcers are a serious complication to diabetes that could lead to amputation and death. Split-thickness skin graft (STSG) has been proposed by some authors to treat noninfected diabetic wounds, mainly those found in the leg and on the dorsum of the foot. No quantitative evidence synthesis over this technique has been reported in the literature. Read More

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http://dx.doi.org/10.1177/1534734619832123DOI Listing
March 2019
10 Reads
1.194 Impact Factor

Clinical Profile and Outcome in Patients of Diabetic Foot Infection.

Int J Appl Basic Med Res 2019 Jan-Mar;9(1):14-19

Department of Internal Medicine, All India Institute of Medical Sciences, New Delhi, India.

Purpose: The aim is to study the clinical profile and outcome of patients presenting with diabetic foot infections (DFI).

Methods: This was a prospective study recruiting patients >18 years of age, with DFI. All patients underwent a detailed history and clinical examination. Read More

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http://dx.doi.org/10.4103/ijabmr.IJABMR_278_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385536PMC
March 2019
4 Reads

Serum vitamin D and diabetic foot complications.

Diabet Foot Ankle 2019 19;10(1):1579631. Epub 2019 Feb 19.

Department of Orthopaedic Surgery, UT Southwestern Medical Center, Dallas, TX, USA.

: Foot complications such as ulceration and neuropathy are common complications of diabetes mellitus (DM). Previous reports have demonstrated a possible increased risk of these complications in diabetic patients with low levels of serum vitamin D.: The purpose of this study is to compare serum vitamin D levels in diabetic patients with and without Charcot neuroarthropathy (CN), peripheral arterial disease (PAD), infection (DFI), ulceration (DFU), and peripheral neuropathy (DPN). Read More

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http://dx.doi.org/10.1080/2000625X.2019.1579631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383621PMC
February 2019
5 Reads

Human Wounds and Its Burden: An Updated Compendium of Estimates.

Authors:
Chandan K Sen

Adv Wound Care (New Rochelle) 2019 Feb 13;8(2):39-48. Epub 2019 Feb 13.

Department of Surgery, Indiana University Health Comprehensive Wound Center, Indianapolis, Indiana.

A 2018 retrospective analysis of Medicare beneficiaries identified that ∼8.2 million people had wounds with or without infections. Medicare cost estimates for acute and chronic wound treatments ranged from $28. Read More

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http://dx.doi.org/10.1089/wound.2019.0946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389759PMC
February 2019
3 Reads

The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis.

J Infect 2019 Feb 22. Epub 2019 Feb 22.

Division of Genetics and Genomics, The Roslin Institute, University of Edinburgh, Edinburgh, UK; Intensive Care Unit, Royal Infirmary Edinburgh, Edinburgh, UK.

Objectives: To assess the utility of the neutrophil:lymphocyte (NLR), lymphocyte:monocyte (LMR) and platelet:lymphocyte ratios (PLR) as infection biomarkers.

Methods: PubMed/MEDLINE, Embase and Cochrane databases were searched to identify eligible articles. Studies of diagnosis, severity or outcome were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453193005
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http://dx.doi.org/10.1016/j.jinf.2019.02.006DOI Listing
February 2019
7 Reads

Risk factors for mortality among patients undergoing major amputations due to infected diabetic feet.

J Vasc Bras 2018 Oct-Dec;17(4):296-302

Universidade Federal de Minas Gerais - UFMG, Departamento de Cirurgia, Belo Horizonte, MG, Brasil.

Background: Foot ulcers in patients with diabetes are a major public health problem and are often associated with lower limbs amputation and mortality in this population.

Objectives: To investigate the risk factors associated with mortality in patients with infected diabetic foot ulcers and major lower limb amputations.

Methods: This was an observational, retrospective, case-control study with a sample of 78 patients with infected diabetic foot ulcers who had major lower limb amputations at a Vascular Surgery Service at a university hospital. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1677-5449.010717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375264PMC
February 2019
4 Reads

Wound Coverage Options for Soft Tissue Defects Following Calcaneal Fracture Management (Operative/Surgical).

Clin Podiatr Med Surg 2019 Apr 12;36(2):323-337. Epub 2018 Dec 12.

Plastic Reconstructive and Orthopaedic Surgery, University of Pennsylvania Health System, Perelman Center for Advanced Medicine, 3400 Civic Center Boulevard, South Pavilion, 1st Floor, Philadelphia, PA 19104, USA.

Soft tissue defects and wound healing complications related to calcaneus fractures may result in significant morbidity. The management of these soft tissue complications requires following reconstructive principles that provide the requisites for preservation of the injured limb and the maximization of function. Soft tissue complications are addressed with methods that commensurate with the degree of injury, ranging from local wound care to free flap reconstruction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08918422183009
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http://dx.doi.org/10.1016/j.cpm.2018.10.012DOI Listing
April 2019
6 Reads

A meta-analysis of the relationship between foot local characteristics and major lower extremity amputation in diabetic foot patients.

J Cell Biochem 2019 Jun 19;120(6):9091-9096. Epub 2019 Feb 19.

Department of Peripheral Vascular, Beijing University of Chinese Medicine, Dongzhimen Hospital, Beijing, China.

Objective: To clarify and quantify risk factors among local characteristics of the foot for major amputation in diabetic foot patients.

Methods: Articles published before January 2018 on PubMed and Embase were conducted observational studies about risk factors for major amputation in patients with diabetic foot were retrieved and systematically reviewed by using Stata 12.0 statistical software. Read More

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http://doi.wiley.com/10.1002/jcb.28183
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http://dx.doi.org/10.1002/jcb.28183DOI Listing
June 2019
7 Reads

Ankle fusion following failed initial treatment of complex ankle fractures in neuropathic diabetics.

Foot Ankle Surg 2019 Feb 5. Epub 2019 Feb 5.

The Department of Orthopaedic Surgery and Rehabilitation, Loyola University Health System, 2160 South First Avenue, Maywood, IL 60153, United States. Electronic address:

Background: Unstable ankle fractures in diabetics with peripheral neuropathy have an increased risk of postoperative complications, often leading to amputation. Primary ankle arthrodesis has been suggested as an alternative when acceptable reduction and mechanical stabilization cannot be obtained.

Methods: Over a fourteen year period, thirteen diabetic patients with peripheral neuropathy underwent an attempt at primary ankle arthrodesis following the early post-fracture development of acute neuropathic (Charcot) deformity of the ankle after sustaining a low energy unstable ankle fracture. Read More

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http://dx.doi.org/10.1016/j.fas.2019.01.010DOI Listing
February 2019
1 Read

Review on Wearables to Monitor Foot Temperature in Diabetic Patients.

Sensors (Basel) 2019 Feb 14;19(4). Epub 2019 Feb 14.

Department of Nursing, University of Extremadura, E06006 Badajoz, Spain.

One of the diseases that could affect diabetic patients is the diabetic foot problem. Unnoticed minor injuries and subsequent infection can lead to ischemic ulceration, and may end in a foot amputation. Preliminary studies have shown that there is a positive relationship between increased skin temperature and the pre⁻ulceration phase. Read More

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http://www.mdpi.com/1424-8220/19/4/776
Publisher Site
http://dx.doi.org/10.3390/s19040776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412611PMC
February 2019
7 Reads

Treatment of diabetic foot wounds with acellular fish skin graft rich in omega-3: a prospective evaluation.

J Wound Care 2019 Feb;28(2):76-80

Consultant Vascular Surgeon; Department of Vascular Surgery, Royal Cornwall Hospital, UK.

Objective:: To evaluate the potential benefit of an intact fish skin graft rich in omega-3 (Kerecis Omega3), in the management of postoperative diabetic foot wounds.

Method:: Prospective evaluation in eight patients with diabetes following forefoot surgery. The dressing was applied weekly for a period of six weeks in the diabetic foot clinic. Read More

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http://dx.doi.org/10.12968/jowc.2019.28.2.76DOI Listing
February 2019
1 Read

Hard-to-heal diabetic foot ulcers treated using negatively charged polystyrene microspheres: a prospective case series.

J Wound Care 2019 Feb;28(2):104-109

Diabetic Foot Unit, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.

Objective:: To describe the outcomes of a new product based on negatively charged polystyrene microspheres (NCM) technology, in non-responding diabetic foot ulcers (DFU).

Methods:: A clinical case series of patients with a hard-to-heal DFU treated with NCM were recruited between March and June 2017 in a specialised diabetic foot unit. DFUs were treated daily with NCM over four weeks, although the health professional could decide to continue NCM treatment in some patients. Read More

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http://www.magonlinelibrary.com/doi/10.12968/jowc.2019.28.2.
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http://dx.doi.org/10.12968/jowc.2019.28.2.104DOI Listing
February 2019
2 Reads

Pentraxin-3: A new parameter in predicting the severity of diabetic foot infection?

Int Wound J 2019 Feb 15. Epub 2019 Feb 15.

Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Firat University, Elazig, Turkey.

This study was undertaken to evaluate the diagnostic and prognostic values of pentraxin-3 (PTX-3) in patients with infected diabetic foot ulcers (IDFU) as well as to assess the association between PTX-3 levels and IDFU severity. This study included 60 IDFU patients (Group 1), 45 diabetic patients without DFU (Group 2), and 45 healthy controls. Patients with IDFU were divided into mild, moderate, and severe subgroups based on classification of clinical severity. Read More

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http://dx.doi.org/10.1111/iwj.13075DOI Listing
February 2019
2 Reads

Development of Charcot Neuroarthropathy in Diabetic Patients who Received Kidney or Kidney-Pancreas Transplants.

J Foot Ankle Surg 2019 Feb 11. Epub 2019 Feb 11.

Assistant Professor, Podiatric Medicine and Surgery Residency Program, The Ohio State University Wexner Medical Center, Columbus, OH.

Only a small percentage of the general diabetic population develops Charcot neuroarthropathy. Charcot arthropathy greatly increases the risk of foot complications. At our academic institution, there appeared to be an increased incidence of Charcot arthropathy in transplant patients. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.09.022DOI Listing
February 2019
1 Read

A neglected causative agent in diabetic foot infection: a retrospective evaluation of 13 patients with fungal etiology

Turk J Med Sci 2019 Feb 11;49(1):81-86. Epub 2019 Feb 11.

Background/aim: Clinicians often neglect fungal infections and do not routinely investigate deep tissue from the wound for fungal culture and sensitivity due to insufficient information in the literature. In this study, we aimed to evaluate fungal etiology of invasive fungal diabetic foot which is rarely reported in the literature.

Materials And Methods: The patients who were unresponsive to antibiotic therapy and those with positive fungal in bone or deep tissue culture were enrolled in the study. Read More

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http://dx.doi.org/10.3906/sag-1809-74DOI Listing
February 2019
3 Reads

Methicillin-Resistant Staphylococcus aureus Endocarditis from a Diabetic Foot Ulcer .

J Am Podiatr Med Assoc 2018 Nov;108(6):528-531

Diabetic foot infections are a common cause of morbidity and mortality in the United States, and successful treatment often requires an aggressive and prolonged approach. Recent work has elucidated the importance of appropriate therapy for a given severity of diabetic foot infection, and highlighted the ongoing risk such patients have for subsequent invasive life-threatening infection should diabetic foot ulcers fail to heal. The authors describe the case of a man with diabetes who had prolonged, delayed healing of a diabetic foot ulcer. Read More

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http://www.japmaonline.org/doi/10.7547/17-139
Publisher Site
http://dx.doi.org/10.7547/17-139DOI Listing
November 2018
10 Reads

Safety of SGLT2 Inhibitors in Patients with Diabetes Mellitus.

Curr Drug Saf 2019 Feb 6. Epub 2019 Feb 6.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER-Raebareli), Lucknow (UP). India.

Background: Recently, Food and Drug Administration (FDA) has approved sodium/glucose co-transporter 2 (SGLT2) inhibitors for the treatment of diabetes mellitus. However, regarding adverse drug reactions (ADRs) of SGLT2 inhibitors in large group of population, very less information is available. Thus, we have tried to find out the risk profile of SGLT 2 inhibitors. Read More

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http://dx.doi.org/10.2174/1574886314666190206164647DOI Listing
February 2019
8 Reads

Risk factor analysis on the healing time and infection rate of diabetic foot ulcers in a referral wound care clinic.

J Wound Care 2019 Jan;28(Sup1):S4-S13

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.

Objective:: Objectives. To determine the prevalence and risk factors for diabetic foot infection (DFI), and to identify factors associated with delayed wound healing of diabetic foot ulcer (DFU).

Method:: The retrospective study was performed in a referral wound care clinic in Hospital Kuala Lumpur. Read More

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http://dx.doi.org/10.12968/jowc.2019.28.Sup1.S4DOI Listing
January 2019
5 Reads

The use of bioactive glass S53P4 in the treatment of an infected Charcot foot: a case report.

J Wound Care 2019 Jan;28(Sup1):S14-S17

Southwestern Academic Limb Salvage Alliance (SALSA), Department of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA, US.

Objective:: To report a case of successful limb-salvage staged treatment in the treatment of an infected diabetic Charcot foot.

Case Summary:: A 45-year-old male with long-term, uncontrolled type 2 diabetes, six months' history of progressive deformity on the right foot and 45 days of purulent drainage in the lateral aspect of the foot. Patient was diagnosed with an infected Charcot foot with extensive midfoot bone involvement as shown by radiographic and MRI images. Read More

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http://dx.doi.org/10.12968/jowc.2019.28.Sup1.S14DOI Listing
January 2019
3 Reads

Oral amoxicillin-clavulanate for treating diabetic foot infections.

Diabetes Obes Metab 2019 Feb 5. Epub 2019 Feb 5.

Service of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland.

Aim: To assess amoxicillin-clavulanate (AMC) for the oral therapy of diabetic foot infections (DFIs), especially for diabetic foot osteomyelitis (DFO).

Methods: We performed a retrospective cohort analysis among 794 DFI episodes, including 339 DFO cases.

Results: The median duration of antibiotic therapy after surgical debridement (including partial amputation) was 30 days (DFO, 30 days). Read More

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http://dx.doi.org/10.1111/dom.13651DOI Listing
February 2019
13 Reads
6.360 Impact Factor

Discordant isolates in bone specimens from patients with recurrent foot osteomyelitis.

Eur J Clin Microbiol Infect Dis 2019 Apr 5;38(4):767-769. Epub 2019 Feb 5.

Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard (OCL 112), Houston, TX, 77030, USA.

We compared paired operative bone cultures (initial operation and reoperation) for 35 patients who experienced foot osteomyelitis treatment failure at a single hospital. Concordance was poor (kappa = 0.180). Read More

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http://dx.doi.org/10.1007/s10096-019-03470-wDOI Listing
April 2019
3 Reads

Disparities in outcomes of patients admitted with diabetic foot infections.

PLoS One 2019 4;14(2):e0211481. Epub 2019 Feb 4.

Southwest Academic Limb Salvage Alliance (SALSA), Los Angeles, CA, United States of America.

Objective: The purpose of this study was to evaluate the disparities in the outcomes of White, African American (AA) and non-AA minority (Hispanics and Native Americans (NA)), patients admitted in the hospitals with diabetic foot infections (DFIs).

Research Design And Methods: The HCUP-Nationwide Inpatient Sample (2002 to 2015) was queried to identify patients who were admitted to the hospital for management of DFI using ICD-9 codes. Outcomes evaluated included minor and major amputations, open or endovascular revascularization, and hospital length of stay (LOS). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211481PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361439PMC
February 2019
2 Reads

The effects of magnesium and vitamin E co-supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.

Wound Repair Regen 2019 05 11;27(3):277-284. Epub 2019 Feb 11.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

This study was carried out to determine the effects of magnesium and vitamin E co-supplementation on wound healing and metabolic status in patients with diabetic foot ulcer (DFU). The current randomized, double-blind, placebo-controlled trial was conducted among 57 patients with grade 3 DFU. Participants were randomly divided into two groups to take either 250 mg magnesium oxide plus 400 IU vitamin E (n = 29) or placebo per day (n = 28) for 12 weeks. Read More

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http://dx.doi.org/10.1111/wrr.12701DOI Listing
May 2019
3 Reads

Skin Hydration Level as a Predictor for Diabetic Wound Healing: A Retrospective Study.

Plast Reconstr Surg 2019 Apr;143(4):848e-856e

Seoul, Republic of Korea From the Department of Plastic Surgery, Korea University College of Medicine.

Background: In the diabetic foot, the skin may crack and develop fissures, potentially increasing vulnerability to ulceration and infection. Therefore, maintaining adequate skin hydration may be crucial for diabetic wound healing. However, no clinical study has addressed this issue. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005474DOI Listing
April 2019
2 Reads

Screening and preliminary validation of T lymphocyte immunoregulation‑associated long non‑coding RNAs in diabetic foot ulcers.

Mol Med Rep 2019 Mar 17;19(3):2368-2376. Epub 2019 Jan 17.

Department of Surgery, Yijishan Hospital, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.

The present study aimed to investigate the existence of immunoregulation‑associated long non‑coding (lnc)RNAs mediated by T lymphocytes in the wound surfaces of diabetic foot ulcers (DFUs). The wound skin tissues of patients receiving debridement for trauma or DFUs associated with infection were obtained. Dermatological histological changes were observed by pathological staining, and T lymphocyte subsets and inflammation‑associated cytokines were identified. Read More

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http://dx.doi.org/10.3892/mmr.2019.9877DOI Listing
March 2019
5 Reads