3,060 results match your criteria Diabetic Foot Infections


The effect of transcutaneous application of gaseous CO on diabetic chronic wound healing-A double-blind randomized clinical trial.

Int Wound J 2020 Jul 7. Epub 2020 Jul 7.

Department for surgical infections, University Medical center Ljubljana, Ljubljana, Slovenia.

Chronic wounds in diabetics are difficult to treat, therefore, adjuvant therapies have been investigated. Bathing in CO -rich water (spa therapy) has been known in Europe for decades for its positive effect on peripheral vascular disorders. Recently, much effort has been invested in developing optimal application methods of CO . Read More

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http://dx.doi.org/10.1111/iwj.13436DOI Listing

A Bioinformatic Approach to Utilize a Patient's Antibody-Secreting Cells against to Detect Challenging Musculoskeletal Infections.

Immunohorizons 2020 Jun 22;4(6):339-351. Epub 2020 Jun 22.

Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY 14642;

Noninvasive diagnostics for musculoskeletal infections (MSKI) remain challenging. Abs from newly activated, pathogen-specific plasmablasts in human blood, which emerge during an ongoing infection, can be used for diagnosing and tracking treatment response in diabetic foot infections. Using multianalyte immunoassays on medium enriched for newly synthesized Abs (MENSA) from Ab-secreting cells, we assessed anti- IgG responses in 101 MSKI patients (63 culture-confirmed , 38 -negative) and 52 healthy controls. Read More

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http://dx.doi.org/10.4049/immunohorizons.2000024DOI Listing

An internet-based algorithm for diabetic foot infection during the COVID-19 pandemic.

J Foot Ankle Res 2020 Jun 17;13(1):37. Epub 2020 Jun 17.

Department of Endocrinology, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, #3 E. Qingchun Rd, Hangzhou, 310016, China.

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http://dx.doi.org/10.1186/s13047-020-00405-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298919PMC

Mini Invasive Floating Metatarsal Osteotomy for Diabetic Foot Ulcers Under the First Metatarsal Head: A Case Series.

Int J Low Extrem Wounds 2020 Jun 19:1534734620934579. Epub 2020 Jun 19.

Shamir Medical Center, Zerifin, Israel.

Diabetic foot ulcers under the first metatarsal head are difficult to treat and prevent recurrence. The aim of this study is to summarize the results of a distal first metatarsal minimally invasive floating osteotomy for ulcers under the first metatarsal head in patients with diabetic neuropathy. We reviewed files of patients with diabetic neuropathy undergoing a floating first metatarsal osteotomy. Read More

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http://dx.doi.org/10.1177/1534734620934579DOI Listing

Photodynamic Topical Antimicrobial Therapy for Infected Diabetic Foot Ulcers in Patients With Diabetes: A Case Series.

Int J Low Extrem Wounds 2020 Jun 19:1534734620929889. Epub 2020 Jun 19.

UOs Diabetologia and Diabetic Foot Unit USL Toscana Centro, Area Pistoiese, Pistoia, Italy.

Diabetic foot ulcers (DFUs) are common, complex, costly complications, associated with frequent recurrences and increased morbidity and mortality. DFUs can be prevented and their healing can be mostly influenced by appropriately and aggressively managing any infection, but the role of antiseptic therapies in reducing healing time lacks sufficient evidence. Several therapeutic interventions have been developed based on the principles of photomedicine to overcome the issue of poor drug circulation in infected areas, with the aim of killing microbial agents while leaving the surrounding host cells unharmed. Read More

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http://dx.doi.org/10.1177/1534734620929889DOI Listing

Clinical and bacteriological profile of diabetic foot infections in a tertiary care.

J Foot Ankle Res 2020 Jun 16;13(1):36. Epub 2020 Jun 16.

Department of Orthopaedic and Traumatology, Universiti Kebangsaan Malaysia Medical Centre, Hospital Canselor Tunku Muhriz, 56000, Cheras, Malaysia.

Background: Diabetic foot infection is a worldwide health problem is commonly encountered in daily practice. This study was conducted to identify the microbiological profile and antibiotic sensitivity patterns of causative agents identified from diabetic foot infections (DFIs). In addition, the assessment included probable risk factors contributing to infection of ulcers that harbour multidrug-resistant organisms (MDROs) and their outcomes. Read More

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http://dx.doi.org/10.1186/s13047-020-00406-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298861PMC

Clinical evaluation of tibiocalcaneal arthrodesis with retrograde intramedullary nail fixation in diabetic patients.

Acta Orthop Traumatol Turc 2020 May;54(3):255-261

Department of Orthopedic Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy.

Objective: The aim of this study was to evaluate clinical and functional outcomes in diabetic patients undergoing tibiocalcaneal arthrodesis using a retrograde nail.

Methods: A total of 12 diabetic patients [8 men and 4 women; mean age at intervention: 56.8 years (range: 27-76 years)] who underwent tibiocalcaneal arthrodesis by a retrograde nail were enrolled in this study. Read More

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http://dx.doi.org/10.5152/j.aott.2020.03.334DOI Listing

Management of infected diabetic wound: a scoping review of guidelines.

F1000Res 2019 24;8:737. Epub 2019 May 24.

Reconstructive and Plastic Surgery, CHRU Montpellier, Montpellier, France.

Various international guidelines and recommendations are available for management of diabetic foot infections. We present a review of the guidelines and recommendations for management of these infections. A systematic literature search was conducted through MEDLINE, CENTRAL, EMBASE, LILACS, DARE, and national health bodies. Read More

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http://dx.doi.org/10.12688/f1000research.18978.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265589PMC

Diabetic Foot Infections: The Diagnostic Challenges.

J Clin Med 2020 Jun 8;9(6). Epub 2020 Jun 8.

Diabetic Foot Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

Diabetic foot infections (DFIs) are severe complications of long-standing diabetes, and they represent a diagnostic challenge, since the differentiation between osteomyelitis (OM), soft tissue infection (STI), and Charcot's osteoarthropathy is very difficult to achieve. Nevertheless, such differential diagnosis is mandatory in order to plan the most appropriate treatment for the patient. The isolation of the pathogen from bone or soft tissues is still the gold standard for diagnosis; however, it would be desirable to have a non-invasive test that is able to detect, localize, and evaluate the extent of the infection with high accuracy. Read More

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http://dx.doi.org/10.3390/jcm9061779DOI Listing

Association between sodium-glucose cotransporter 2 (SGLT2) inhibitors and lower extremity amputation: A systematic review and meta-analysis.

PLoS One 2020 5;15(6):e0234065. Epub 2020 Jun 5.

Center for Drug Safety and Effectiveness, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.

Background: The association between sodium-glucose cotransporter 2 inhibitors (SGLT2i's) and lower extremity amputation is unclear.

Purpose: To systematically review randomized control trials (RCTs) and observational studies quantifying risk of lower extremity amputations associated with SGLT2i use.

Data Sources And Study Selection: We searched PubMed, EMBASE, Scopus, and the Cochrane Central Register of Controlled Trials from January 2011 to February 2020 for RCTs and observational studies including lower extremity amputation outcomes for individuals with type 2 diabetes mellitus treated with SGLT2i's vs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234065PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274434PMC

Dalbavancin for the Treatment of Complicated Gram-Positive Skin and Soft Tissue Infections.

Int J Low Extrem Wounds 2020 Jun 5:1534734620921677. Epub 2020 Jun 5.

University Hospital of Alexandroupolis, Alexandroupolis, Greece.

New antimicrobial agents have been developed to treat infections caused by methicillin-resistant and other multidrug-resistant pathogens. Dalbavancin is a novel semisynthetic lipoglycopeptide antibiotic, particularly active against methicillin-resistant . Due to its unique pharmacological characteristics and longer half-life, it can be administered once-weekly or every 15 days and in outpatient setting. Read More

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http://dx.doi.org/10.1177/1534734620921677DOI Listing

The Impact of Multidrug-Resistant Organisms on Outcomes in Patients With Diabetic Foot Infections.

Open Forum Infect Dis 2020 May 6;7(5):ofaa161. Epub 2020 May 6.

Division of Infectious Diseases, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Background: Multidrug-resistant organisms (MDROs) are important diabetic foot infection (DFI) pathogens. This study evaluated the impact of DFIs associated with MDRO pathogens (DFI-MDRO) on clinical outcomes.

Methods: Adults admitted to Detroit Medical Center from January 2012 to December 2015 with culture-positive DFI were included. Read More

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http://dx.doi.org/10.1093/ofid/ofaa161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255643PMC

Comparison of White Blood Cell Scintigraphy, FDG PET/CT and MRI in Suspected Diabetic Foot Infection: Results of a Large Retrospective Multicenter Study.

J Clin Med 2020 May 30;9(6). Epub 2020 May 30.

Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.

Diabetic foot infections (DFIs) represent one of the most frequent and disabling morbidities of longstanding diabetes; therefore, early diagnosis is mandatory. The aim of this multicenter retrospective study was to compare the diagnostic accuracy of white blood cell scintigraphy (WBC), F-fluorodeoxyglucose positron emission tomography/computed tomography ((F) FDG PET/CT), and Magnetic Resonance Imaging (MRI) in patients with suspected DFI. Images and clinical data from 251 patients enrolled by five centers were collected in order to calculate the sensitivity, specificity, and accuracy of WBC, FDG, and MRI in diagnosing osteomyelitis (OM), soft-tissue infection (STI), and Charcot osteoarthropathy. Read More

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http://dx.doi.org/10.3390/jcm9061645DOI Listing

Adjunctive rifampin therapy for diabetic foot osteomyelitis: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 May;99(22):e20375

Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, P.R. China.

Introduction: The prevalence of diabetes continues to rise around the world. Diabetic foot is a serious complication of diabetes, and diabetic patients with diabetic foot osteomyelitis (DFO) have a fourfold increased risk of amputation, usually indicating death. Therefore, it is particularly important to seek a more effective treatment for DFO. Read More

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http://dx.doi.org/10.1097/MD.0000000000020375DOI Listing

Methylene blue mediated antimicrobial photodynamic therapy in clinical human studies: The state of the art.

Photodiagnosis Photodyn Ther 2020 May 27:101828. Epub 2020 May 27.

Postgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho/UNINOVE, 249 Vergueiro Street, Liberdade, São Paulo, SP, 01504-001, Brazil. Electronic address:

Background: The goals of this study were to update the information about aPDT when using methylene blue (MB) for the treatment of human clinical infections of different etiologies, except for dentistry applications, and to investigate the best parameters of MB to achieve this.

Methods: This study was a systematic literature review performed according to the PRISMA guidelines. A literature search was performed for studies with adult human patients (>18 years-old) published in the English, French, Spanish, Portuguese, and Italian languages when using the electronic databases of MEDLINE, Embase, OpenGrey, and LILACS. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101828DOI Listing

Epidemiology and risk factors of Staphylococcus aureus CC398 bone and joint infections.

BMC Infect Dis 2020 May 29;20(1):384. Epub 2020 May 29.

Maladies infectieuses et tropicales, Centre Hospitalier Régional Universitaire, 25030, Besancon, France.

Background: A particular ability of the Staphylococcus aureus clonal complex 398 (CC398) to cause bone and joint infections (BJI) remains questionable, since some studies have described high prevalence of MSSA CC398 in prosthetic joint infection (PJI) and diabetic foot ostemolyelitis (DFO). Here, we described the long-term epidemiology of CC398 among S. aureus isolated from BJI and identified risk factors associated with CC398. Read More

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http://dx.doi.org/10.1186/s12879-020-05098-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260739PMC

A comparative assessment of clinical, pharmacological and antimicrobial profile of novel anti-methicillin-resistant agent levonadifloxacin: Therapeutic role in nosocomial and community infections.

Indian J Med Microbiol 2019 Oct-Dec;37(4):478-487

Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.

Staphylococcus aureus is of significant clinical concern in both community- and hospital-onset infections. The key to the success of S. aureus as a pathogen is its ability to swiftly develop antimicrobial resistance. Read More

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http://dx.doi.org/10.4103/ijmm.IJMM_20_34DOI Listing

Comparative Microbiological and Whole-Genome Analysis of Populations in the Oro-Nasal Cavities, Skin and Diabetic Foot Ulcers of Patients With Type 2 Diabetes Reveals a Possible Oro-Nasal Reservoir for Ulcer Infection.

Front Microbiol 2020 30;11:748. Epub 2020 Apr 30.

Microbiology Research Unit, Division of Oral Biosciences, Dublin Dental University Hospital, Trinity College Dublin, The University of Dublin, Dublin, Ireland.

Patients with type 2 diabetes are at higher risk for periodontal disease and diabetic foot ulcer infections (DFUIs), the latter of which are predominantly caused by staphylococcal bacteria. Staphylococci have also been detected in the mouth, nose and gums (the oro-nasal cavity) of patients with periodontal disease and can move between the mouth and nose. The present study investigated if the oro-nasal cavity and/or periodontal pockets (PPs) in diseased gum tissue can provide a microbial reservoir for DFUIs. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212350PMC

Calculated initial parenteral treatment of bacterial infections: Skin and soft tissue infections.

GMS Infect Dis 2020 26;8:Doc11. Epub 2020 Mar 26.

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Frankfurt/Main, Germany.

This is the ninth chapter of the guideline "Calculated Parenteral Initial Therapy of Adult Bacterial Disorders - Update 2018" in the 2 updated version. The German guideline by the Paul-Ehrlich-Gesellschaft für Chemotherapie e.V. Read More

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http://dx.doi.org/10.3205/id000055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186924PMC

Efficacy of Maggot Debridement Therapy on Refractory Atypical Diabetic Foot Ulcers: An Open-Label Study.

Int J Low Extrem Wounds 2020 May 5:1534734620920403. Epub 2020 May 5.

Islamic Azad University of Shahreza, Isfahan, Iran.

Atypical or refractory diabetic foot ulcers (DFUs) are still a major health problem. Maggot debridement therapy (MDT) by larva of is an ancient and a modern option for wound healing. It works by debridement, stimulation of wound healing, and disinfection. Read More

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http://dx.doi.org/10.1177/1534734620920403DOI Listing

and Antibiotic Capacity of Two Host Defense Peptides.

Antimicrob Agents Chemother 2020 Jun 23;64(7). Epub 2020 Jun 23.

Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Mexico City, Mexico

Two nonamidated host defense peptides named Pin2[G] and FA1 were evaluated against three types of pathogenic bacteria: two ( UPD13 and UPD3) isolated from diabetic foot ulcer patients, and another ( serovar Typhimurium [ATCC 14028]) from a commercial collection. experiments showed that the antimicrobial performance of the synthetic peptides Pin2[G] and FA1 was modest, although FA1 was more effective than Pin2[G]. In contrast, Pin2[G] had superior anti-infective activity to FA1 in rabbit wound infections by the diabetic foot ulcer pathogens UPD13 and UPD3. Read More

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http://dx.doi.org/10.1128/AAC.00145-20DOI Listing

Levonadifloxacin, a recently approved benzoquinolizine fluoroquinolone, exhibits potent in vitro activity against contemporary Staphylococcus aureus isolates and Bengal Bay clone isolates collected from a large Indian tertiary care hospital.

J Antimicrob Chemother 2020 May 3. Epub 2020 May 3.

Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India.

Objectives: Levonadifloxacin (WCK 771; IV) and its prodrug alalevonadifloxacin (WCK 2349; oral) are benzoquinolizine fluoroquinolones, recently approved in India for the treatment of acute bacterial skin and skin structure infections with concurrent bacteraemia and diabetic foot infections. Ahead of its market launch, the present study aimed to assess the in vitro activity of levonadifloxacin against contemporary Staphylococcus aureus isolates collected from a large tertiary care hospital in India. Additionally, levonadifloxacin activity was tested against hVISA and Bengal Bay clone MRSA isolates. Read More

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http://dx.doi.org/10.1093/jac/dkaa142DOI Listing
May 2020
5.313 Impact Factor

Distribution of blaTEM, blaSHV, blaCTX-M, blaOXA, and blaDHA in Proteus mirabilis Isolated from Diabetic Foot Infections in Erbil, Iraq.

Cell Mol Biol (Noisy-le-grand) 2020 Apr 20;66(1):88-94. Epub 2020 Apr 20.

College of Science, Salahaddin University, Erbil, Kurdistan Region-Iraq.

Diabetic foot infection is considered to be one of the most important medical, economic, and social problems and a major cause of morbidity and mortality. Proteus mirabilis is a common etiologic agent of diabetic foot infections. This study aimed to determine the prevalence of beta-lactamase genes in P. Read More

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Economic evaluations considering costs and outcomes of diabetic foot ulcer infections: A systematic review.

PLoS One 2020 30;15(4):e0232395. Epub 2020 Apr 30.

College of Medicine and Public Health, Flinders University, Bedford Park, South Australia.

Background: Diabetic foot ulcer (DFU) is a severe complication of diabetes and particularly susceptible to infection. DFU infection intervention efficacy is declining due to antimicrobial resistance and a systematic review of economic evaluations considering their economic feasibility is timely and required.

Aim: To obtain and critically appraise all available full economic evaluations jointly considering costs and outcomes of infected DFUs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232395PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192475PMC

[Complex treatment of patients with pyo-necrotic complications of the neuropathic form of diabetic foot syndrome].

Khirurgiia (Mosk) 2020 (4):81-87

Kuban State Medical University of the Ministry of Health of Russia, Department of General Surgery, Krasnodar, Russia.

Objective: Of study is improving the results of treatment of patients with pyo-necrotic complications of diabetic foot syndrome by including the method of negative pressure wound treatment in the complex treatment program in combination with using of the combined antibacterial drug Cifran ST and immunocorrective therapy.

Material And Methods: The results of examination and treatment of 184 patients with pyo-necrotic complications of the neuropathic form of diabetic foot syndrome were analyzed. According to choice of treatment methods in the postoperative period all patients were divided into two groups. Read More

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http://dx.doi.org/10.17116/hirurgia202004181DOI Listing

COVID-19 and Diabetic Foot: Will the Lamp Burn Bright?

Int J Low Extrem Wounds 2020 Jun 22;19(2):111. Epub 2020 Apr 22.

Diabetes Centre-Diabetic Foot Clinic, Second Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece.

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http://dx.doi.org/10.1177/1534734620921382DOI Listing

How ESKD complicates the management of diabetic foot ulcers: The vital role of the dialysis team in prevention, early detection, and support of multidisciplinary treatment to reduce lower extremity amputations.

Semin Dial 2020 05 10;33(3):245-253. Epub 2020 Apr 10.

Division of Nephrology, Tufts Medical Center, Boston, MA, USA.

Diabetic foot ulcers do not heal as well in ESKD as in the absence of kidney failure, and rates of recurrent foot ulcers, as well as lower extremity amputation, are higher. This review of the literature highlights the vital role of the dialysis team in prevention, early detection, and support of treatment of diabetic foot ulcers. Our review has five goals-(a) increase nephrologists' understanding of the high morbidity and mortality associated with chronic foot ulcers and (lower extrimity) LE amputations in ESKD; (b) promote nephrologists' understanding of grading systems for diabetic foot ulcer severity, in order to expedite communication with local diabetic foot experts; (c) promote collaboration between nephrologists and infectious disease specialists regarding the dose, route, and delivery logistics of intravenous antibiotics for infected chronic foot ulcers, in particular in the presence of osteomyelitis and other deep-seated infections; (d) increase the awareness of dialysis nurses, technicians, dietitians, social workers and administrators regarding evidence-based and multidisciplinary approaches to patients' diabetic foot ulcers; (e) encourage the application of published works integrating patient-centered diabetic foot education into the dialysis setting to reduce lower extremity amputations. Read More

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http://dx.doi.org/10.1111/sdi.12875DOI Listing

Advanced glycation end products reduce macrophage-mediated killing of Staphylococcus aureus by ARL8 upregulation and inhibition of autolysosome formation.

Eur J Immunol 2020 Apr 6. Epub 2020 Apr 6.

Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.

Staphylococcus aureus (S. aureus), a pathogen most frequently found in diabetic foot ulcer infection (DFI), was recently suggested as an intracellular pathogen. Autophagy in professional phagocytes like macrophages allows selective destruction of intracellular pathogens, and its dysfunction can increase the survival of internalized pathogens, causing infections to worsen and spread. Read More

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http://dx.doi.org/10.1002/eji.201948477DOI Listing
April 2020
4.034 Impact Factor

Pexiganan in Combination with Nisin to Control Polymicrobial Diabetic Foot Infections.

Antibiotics (Basel) 2020 Mar 20;9(3). Epub 2020 Mar 20.

Centro de Investigação Interdisciplinar em Sanidade Animal (CIISA), Faculdade de Medicina Veterinária, Universidade de Lisboa, Avenida da Universidade Técnica, 1300-477 Lisboa, Portugal.

Diabetic foot ulcers (DFUs) are major complications of Diabetes being responsible for significant morbidity and mortality. DFUs frequently become chronically infected by a complex community of bacteria, including multidrug-resistant and biofilm-producing strains of and . Diabetic foot infections (DFI) are often recalcitrant to conventional antibiotics and alternative treatment strategies are urgently needed. Read More

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http://dx.doi.org/10.3390/antibiotics9030128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7148459PMC

Host Defense Peptide RNase 7 Is Down-regulated in the Skin of Diabetic Patients with or without Chronic Ulcers, and its Expression is Altered with Metformin.

Arch Med Res 2020 May 27;51(4):327-335. Epub 2020 Mar 27.

Unidad de Investigación Médica-Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas, México. Electronic address:

Background: Diabetic foot ulcers (DFUs) are one of the main complications in patients with type 2 diabetes mellitus (DM2), previous studies have reported that DM2 patients have lower production of host defense peptides (HDP).

Aim Of The Study: To investigate the expression of RNase 7, cathelicidin, HBD-2, and psoriasin in biopsies obtained from DM2 patients with or without DFU.

Methods: Biopsies from DFU patients grade 3 according to Wagner's classification, from diabetic patients without ulcer and from healthy donors were obtained. Read More

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http://dx.doi.org/10.1016/j.arcmed.2020.03.006DOI Listing

[The Management of Blood Glucose Should be Emphasized in the Treatment of COVID-19].

Sichuan Da Xue Xue Bao Yi Xue Ban 2020 Mar;51(2):146-150

Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.

Based on the higher mortality and the higher proportion of critically ill adults in coronavirus disease 2019 (COVID-19) patients with diabetes, good inpatient glycemic control is particularly important in the comprehensive treatment of COVID-19. Individualized blood glucose target goals and treatment strategies should be made according to specific circumstances of COVID-19 inpatients with diabetes. For mild patients, a strict glycemic control target (fasting plasma glucose (FPG) 4. Read More

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http://dx.doi.org/10.12182/20200360606DOI Listing

All Feet On Deck-The Role of Podiatry During the COVID-19 Pandemic: .

J Am Podiatr Med Assoc 2020 Mar 25. Epub 2020 Mar 25.

Professor of Surgery and Director, Southwestern Academic Limb Salvage Alliance (SALSA), Keck School of Medicine of University of Southern California, Los Angeles, California.

The COVID-19 pandemic is driving significant change in the healthcare system and disrupting the best practices for diabetic limb preservation, leaving large numbers of patients without care. Patients with diabetes and foot ulcers are at increased risk for infections, hospitalization, amputations, and death. Podiatric care is associated with fewer diabetes-related amputations, ER visits, hospitalizations, length-of-stay, and costs. Read More

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http://dx.doi.org/10.7547/20-051DOI Listing

Evaluation of mortality risk factors in diabetic foot infections.

Int Wound J 2020 Aug 20;17(4):880-889. Epub 2020 Mar 20.

Department of Infectious Diseases and Clinical Microbiology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey.

Identifying risk factors for mortality is crucial in the management of diabetic foot syndrome. We aimed to evaluate risk factors for mortality in patients with diabetic foot infection (DFI). A retrospective chart review was conducted on 401 patients from 2010 through 2019. Read More

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http://dx.doi.org/10.1111/iwj.13343DOI Listing

Prevalence of metallo-β-lactamase-producing isolated from diabetic foot infections in Iraq.

New Microbes New Infect 2020 May 16;35:100661. Epub 2020 Feb 16.

College of Medicine, Jabir Ibn Hayyan Medical University, Al-Najaf, Iraq.

Metallo-β-lactamase (MBL)-producing is a major cause of nosocomial infections. However, there is little information in Iraq regarding its prevalence in patients with diabetic foot ulcer. Carbapenems are efficient antibiotics against extended-spectrum β-lactamase-producing . Read More

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http://dx.doi.org/10.1016/j.nmni.2020.100661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076140PMC

Guidelines on the diagnosis and treatment of foot infection in persons with diabetes (IWGDF 2019 update).

Diabetes Metab Res Rev 2020 03;36 Suppl 1:e3280

Department of Internal Medicine, Infection and Immunity Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines on the prevention and management of diabetic foot disease since 1999. This guideline is on the diagnosis and treatment of foot infection in persons with diabetes and updates the 2015 IWGDF infection guideline. On the basis of patient, intervention, comparison, outcomes (PICOs) developed by the infection committee, in conjunction with internal and external reviewers and consultants, and on systematic reviews the committee conducted on the diagnosis of infection (new) and treatment of infection (updated from 2015), we offer 27 recommendations. Read More

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http://dx.doi.org/10.1002/dmrr.3280DOI Listing

Diagnosis of infection in the foot in diabetes: a systematic review.

Diabetes Metab Res Rev 2020 03;36 Suppl 1:e3281

Department of Internal Medicine, Section of Infectious Diseases, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Infection and Immunity Institute, Amsterdam, The Netherlands.

Background: Securing an early accurate diagnosis of diabetic foot infections and assessment of their severity are of paramount importance since these infections can cause great morbidity and potentially mortality and present formidable challenges in surgical and antimicrobial treatment.

Methods: In June 2018, we searched the literature using PuEbMed and EMBASE for published studies on the diagnosis of diabetic foot infection. On the basis of predetermined criteria, we reviewed prospective controlled, as well as noncontrolled, studies in any language, seeking translations for those not in English. Read More

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http://dx.doi.org/10.1002/dmrr.3281DOI Listing

Interventions in the management of infection in the foot in diabetes: a systematic review.

Diabetes Metab Res Rev 2020 03;36 Suppl 1:e3282

Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.

The optimal approaches to managing diabetic foot infections remain a challenge for clinicians. Despite an exponential rise in publications investigating different treatment strategies, the various agents studied generally produce comparable results, and high-quality data are scarce. In this systematic review, we searched the medical literature using the PubMed and Embase databases for published studies on the treatment of diabetic foot infections as of June 2018. Read More

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http://dx.doi.org/10.1002/dmrr.3282DOI Listing

Evolutionary trends in bacteria isolated from moderate and severe diabetic foot infections in a Portuguese tertiary center.

Diabetes Metab Syndr 2020 May - Jun;14(3):205-209. Epub 2020 Feb 18.

Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Do Porto, Portugal.

Introduction: Diabetic Foot infections (DFI) are a major cause of hospitalization in patients with diabetes. The microbiological study of diabetic ulcers is essential to adequate antibiotic therapy and to minimize the selection of resistant microorganisms. The aim of this study was to characterize and to compare the evolution of isolated microorganisms between the biennium 2010-2011 and 2016-2017, in hospitalized patients with DFI. Read More

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http://dx.doi.org/10.1016/j.dsx.2020.02.010DOI Listing
February 2020

A retrospective analysis of the microbiology of diabetic foot infections at a Scottish tertiary hospital.

BMC Infect Dis 2020 Mar 12;20(1):218. Epub 2020 Mar 12.

Edinburgh Medical School: Biomedical Sciences, Infection Medicine, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.

Background: This study represents the first Scottish retrospective analysis of the microbiology of diabetic foot infections (DFIs). The aims were to compare the microbiological profile of DFIs treated at a Scottish tertiary hospital to that in the literature, gather data regarding antimicrobial resistance and investigate potential trends between the microbiological results and nature or site of the clinical sample taken and age or gender of the patients.

Methods: A retrospective analysis of wound microbiology results was performed, data were obtained from one multidisciplinary outpatient foot clinic during the 12 months of the year 2017. Read More

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http://dx.doi.org/10.1186/s12879-020-4923-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068857PMC

Peripheral Gangrene and Extremity Amputations - Painful Preventable Sequelae of Meningococcal Septicaemia: Case Series Reports.

West Afr J Med 2020 Apr-Jun;37(2):189-196

Department of Paediatrics Ahmadu Bello University Teaching Hospital, Zaria, Kaduna State,Nigeria.

Extremity gangrene is a fairly common pathology, which complicates systemic vascular and endocrine diseases. Most often, it is encountered in diseases like uncontrolled Diabetes Mellitus, presenting as diabetic foot gangrene, severe peripheral arteriosclerosis with gangrene of the extremity complicating severe uncontrolled systemic hypertension and meningococcal septicaemia with peripheral gangrene. It also occurs in some cases of snake bite as well as frost bite (in regions with extreme cold weather conditions). Read More

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Chopart Amputation: Questioning the Clinical Efficacy of a Long-standing Surgical Option for Diabetic Foot Infection.

J Am Acad Orthop Surg 2020 Mar 6. Epub 2020 Mar 6.

From the Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center, Rochester, NY.

Background: Diabetic foot ulcers with associated infection and osteomyelitis often lead to partial or complete limb loss. Determination of the appropriate level for amputation based on the patient's baseline physical function, extent of infection, vascular patency, and comorbidities can be challenging. Although Chopart amputation preserves greater limb length than more proximal alternatives such as Syme or below-the-knee amputations (BKA), challenges with wound healing and prosthesis fitting have been reported. Read More

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http://dx.doi.org/10.5435/JAAOS-D-19-00757DOI Listing

Does negative pressure wound therapy with irrigation improve clinical outcomes? A randomized clinical trial in patients with diabetic foot infections.

Am J Surg 2020 Feb 27. Epub 2020 Feb 27.

Department of Plastic Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75219, USA; Department of Surgery, University of Cincinnati Medical Center, 231 Albert Sabin Way, ML 0513, Cincinnati, OH 45267, USA. Electronic address:

Aim: To compare the efficacy of Negative Pressure Wound Therapy (NPWT) with and without irrigation with 0.1% polyhexanide-betaine.

Methods: We randomized 150 subjects in a 16-week RCT to compare healing in patients with diabetic foot infections. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.02.044DOI Listing
February 2020

Etiology of major limb amputations at a tertiary care centre in Malawi.

Malawi Med J 2019 12;31(4):244-248

Department of Surgery, University of North Carolina at Chapel Hill, USA.

Introduction: Amputations in low- and middle-income countries (LMICs) represent an important cause of disability and economic hardship. LMIC patients are young and suffer from preventable causes, such as trauma and trauma-related infections. We herein studied the etiology in amputations in a Malawian tertiary care hospital over a 9-year period. Read More

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http://dx.doi.org/10.4314/mmj.v31i4.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036427PMC
December 2019

Correlation between superficial and intra-operative specimens in diabetic foot infections: results of a cross-sectional Tunisian study.

Afr Health Sci 2019 Sep;19(3):2505-2514

Department of Infectious Diseases, Farhat Hached hospital, 4000 Sousse, Tunisia.

Objective: To determine the correlation between superficial, and intra-operative specimens in diabetic foot infections (DFIs).

Methods: We conducted a cross-sectional study in patients with DFIs hospitalized in a Tunisian teaching hospital. Superficial specimens were collected for all patients, and intra-operative specimens were collected in operated patients. Read More

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http://dx.doi.org/10.4314/ahs.v19i3.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040269PMC
September 2019

Antimicrobial and Wound Treatment Aspects of Micro- and Nanoformulations of Carboxymethyl, Dialdehyde, and TEMPO-Oxidized Derivatives of Cellulose: Recent Advances.

Macromol Biosci 2020 04 19;20(4):e1900362. Epub 2020 Feb 19.

Pharmaceuics Research laboratory, Arundel Building, School of Life Sciences, University of Sussex, Brighton, BN1 9QJ, UK.

The remedy for infected chronic wounds such as diabetic foot ulcers is more complicated particularly in the case of patients with an inefficient immune system. Also, fighting against microbial infections in the wound site by available antibiotics may not be effective because of emerging antibiotic resistance properties among pathogenic bacteria and fungi. Recently, applications of micro- and nanoformulations of biomaterials have demonstrated improved therapeutic abilities for wound dressings. Read More

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http://dx.doi.org/10.1002/mabi.201900362DOI Listing