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    1 OF 69

    Risk factors for amputation in patients with diabetic foot infection: a prospective study.
    Int Wound J 2017 Jul 19. Epub 2017 Jul 19.
    Department of Dermatology, Ege University Medical Faculty, Izmir, Turkey.
    There is a variety of diagnostic and therapeutic algorithms for diabetic foot infections (DFIs). Some of them are too difficult to be applied in routine clinical approach. In the routine clinical approach, it is necessary to find new risk factors and end up with a quick and easy assessment of DFIs. Read More

    Bacteriology Of Diabetic Foot In Tertiary Care Hospital; Frequency, Antibiotic Susceptibility And Risk Factors.
    J Ayub Med Coll Abbottabad 2017 Apr-Jun;29(2):234-240
    Department of Medicine, Rawal Institute of Health Sciences, Islamabad, Pakistan.
    Background: Diabetic foot being one of the frequent and disabling complications of diabetes. In view of widespread regional variation in causative organisms and antimicrobial susceptibility, the current study aimed to determine frequency of causative organisms, their antimicrobial susceptibility and associated risk factors.

    Methods: This descriptive cross-sectional study was conducted in 6 months' duration at dept. Read More

    Quantitative Evaluation of Rehabilitation Effect on Peripheral Circulation of Diabetic Foot.
    IEEE J Biomed Health Inform 2017 Jul 13. Epub 2017 Jul 13.
    Diabetics may encounter different foot problems, which easily lead to infection, ulcers, and increased risk of amputation due to nerve or vascular injury. In order to reduce the risk of amputation, Buerger's exercise is one of the frequently used rehabilitation to improve the blood circulation in the lower limbs. However, it is difficult to evaluate the rehabilitation efficiency of Buerger's exercise objectively. Read More

    Frequency Of Common Bacteria And Their Antibiotic Sensitivity Pattern In Diabetics Presenting With Foot Ulcer.
    J Ayub Med Coll Abbottabad 2016 Jul-Sep;28(3):528-533
    Department of Medicine, Khyber Teaching Hospital, Peshawar, Pakistan.
    Background: Foot ulcers are one of the most important complications of diabetes mellitus and often lead to lower limb amputation. Diabetic foot ulcers are susceptible to infection. The objective of this study was to determine the frequency of common bacteria infecting these ulcers and their antibiotic sensitivity pattern. Read More

    Amputation predictors in diabetic foot ulcers treated with hyperbaric oxygen.
    J Wound Care 2017 Jul;26(7):361-366
    Department of Underwater and Hyperbaric Medicine, Faculty of Meram Medicine, Necmettin Erbakan University, Konya, Turkey.
    Objective: Although hyperbaric oxygen therapy (HBOT) has long been used for diabetic foot ulcers (DFUs), its effectiveness is still controversial. The aim of this study was to investigate the efficacy of HBOT in the management of DFUs and identify amputation predictors.

    Method: Patients with chronic DFUs (Wanger grade 2-5) were included in the study, which took place between January 2010 and December 2012. Read More

    Midterm Outcomes From a Pilot Study of Percutaneous Deep Vein Arterialization for the Treatment of No-Option Critical Limb Ischemia.
    J Endovasc Ther 2017 Jul 1:1526602817719283. Epub 2017 Jul 1.
    9 Vascular Surgery Unit, Department of Surgery, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Purpose: To report the initial clinical experience with percutaneous deep vein arterialization (PDVA) to treat critical limb ischemia (CLI) via the creation of an arteriovenous fistula.

    Methods: Seven patients (median age 85 years; 5 women) with CLI and no traditional endovascular or surgical revascularization options (no-option CLI) were recruited in a pilot study to determine the safety of PDVA. All patients were diabetic; 4 had Rutherford category 6 ischemia. Read More

    Advanced MR Imaging Techniques for Differentiation of Neuropathic Arthropathy and Osteomyelitis in the Diabetic Foot.
    Radiographics 2017 Jul-Aug;37(4):1161-1180
    From the MRI Section, Department of Radiology, SERCOSA, Health Time, Calle Carmelo Torres 2, 23007 Jaén, Spain (T.M.N., A.L.A.); Department of Radiology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio (A.L.A.); Department of Radiology, NYU Langone Medical Center, New York, NY (L.S.B.); MRI Section, Department of Radiology, DADISA, Health Time, Cádiz, Spain (M.G.C.); MRI Section, Department of Radiology, RESSALTA, Health Time, Córdoba, Spain (J.B.C.); and Department of Radiology, Clínica Girona, Catalan Institute of Health (IDI), University of Girona, Girona, Spain (J.C.V.).
    Diagnosis and treatment of foot disease in patients with diabetes is a common clinical-radiologic challenge, particularly the differentiation of neuropathic arthropathy from osteomyelitis. Conventional clinical tests and imaging techniques have limited accuracy for evaluation of the diabetic foot. The introduction of morphologic magnetic resonance (MR) imaging in these patients has provided a qualitative leap in diagnosis. Read More

    Total Contact Cast System to Heal Diabetic Foot Ulcers.
    Surg Technol Int 2017 Jul 11;30. Epub 2017 Jul 11.
    Surgical Services, Circleville Foot & Ankle and Berger Health System, Circleville, Ohio.
    Off-loadinga diabetic foot ulcer is a cornerstone of quality wound care for diabetic patients to allow cellular growth in the wound bed. While total contact casts (TCC) have been described as the gold standard for off-loading the wound, the complexity of application and the time commitment for both application and drying have discouraged health professionals from using them. This retrospective case series, conducted in a podiatric practice, evaluated using a TCC system that helps address the three components in which guidelines should be addressed when caring for a diabetic foot: V - vascular management, I - infection management and prevention, and P - pressure relief. Read More

    Results of one-stage or staged amputations of lower limbs consequent to critical limb ischemia and infection.
    Ann Vasc Surg 2017 Jul 6. Epub 2017 Jul 6.
    Department of Surgery and Orthopedics, Botucatu Medical School, Universidade Estadual Paulista, Campus of Botucatu, Botucatu, São Paulo, Brazil. Electronic address:
    Background: Amputations of lower limbs can be conducted as one-stage (OSA) or staged procedures (SA).

    Objective: To analyze technical success and mortality rates of both techniques, as well as factors that might influence outcomes in patients with critical limb ischemia (CLI).

    Methods: Retrospective study of 185 consecutive patients with CLI who underwent amputations in the period 2004-2011. Read More

    End-Stage Renal Disease Negatively Affects Physical Quality of Life in Patients With Diabetic Foot Complications.
    Int J Low Extrem Wounds 2017 Jun 4;16(2):135-142. Epub 2017 May 4.
    2 University of Texas Southwestern Medical Center, Dallas, TX, USA.
    The aim of this study was to evaluate the impact of end-stage renal disease (ESRD) on health-related quality of life (QOL) in patients with diabetic foot disease. We compared a group of 30 diabetic patients with ESRD requiring dialysis to a group of 60 diabetic patients without ESRD. Both groups consisted of patients with active diabetic foot disease (ulcer, Charcot, infection) and were matched with regard to age and gender. Read More

    Bacterial Prevalence and Antibiotic Resistance in Clinical Isolates of Diabetic Foot Ulcers in the Northeast of Tamaulipas, Mexico.
    Int J Low Extrem Wounds 2017 Jun 26;16(2):129-134. Epub 2017 Apr 26.
    1 Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa, Tamaulipas, México.
    Diabetic foot ulcers (DFUs) are a serious and common problem in patients with diabetes mellitus and constitute one of the major causes of lower extremity amputation. The microbiological profile of DFUs depends on the acute or chronic character of the wound. Aerobic gram-positive cocci are the predominant organisms isolated from DFUs. Read More

    Does Everything That's Counted Count? Value of Inflammatory Markers for Following Therapy and Predicting Outcome in Diabetic Foot Infection.
    Int J Low Extrem Wounds 2017 Jun 9;16(2):104-107. Epub 2017 Apr 9.
    2 Baylor College of Medicine, Houston, TX, USA.
    To assess the severity of inflammation associated with diabetic foot infection (DFI), values of inflammatory markers such as white blood count (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and neutrophil to lymphocyte ratio (NLR) are often measured and tracked over time. It remains unclear if these markers can aid the clinician in the diagnosis and management of DFI, and ensure more rational use of antibiotics. Hospitalized adult patients (n = 379) with DFI were retrospectively assessed for abnormal inflammatory markers, correlation between values of inflammatory markers, and clinical diagnosis on initial admission and on last follow-up. Read More

    Expression and Influence of Matrix Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 and Vascular Endothelial Growth Factor in Diabetic Foot Ulcers.
    Int J Low Extrem Wounds 2017 Mar 8;16(1):6-13. Epub 2017 Mar 8.
    1 Wuhan Union Hospital of Huazhong University of Science and Technology, Wuhan, Hubei, China.
    A high matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 (MMP9/TIMP1) ratio is associated with poor ulcer healing, yet how the ratio of MMP9/TIMP1 changes in diabetic foot ulcers (DFUs) with infection and how these changes may affect wound healing remain unclear. Therefore, the objective of this investigation was to explore relationships among the MMP9/TIMP1 ratio, infection, and DFUs. After being informed of the details of this study, 32 patients signed consent forms. Read More

    Enterococci in orthopaedic infections: Who is at risk getting infected?
    J Infect 2017 Jul 1. Epub 2017 Jul 1.
    Infection Control Program, University of Geneva Hospitals and Faculty of Medicine, University of Geneva, Switzerland; Service of Infectious Diseases, University of Geneva Hospitals and Faculty of Medicine, University of Geneva, Switzerland.
    Some orthopaedic patients might be at risk for enterococcal infections and might benefit from adapted perioperative prophylaxis.

    Methods: We performed a single-center cohort of adult patients with orthopaedic infections.

    Results: Among 2740 infection episodes, 665 surgeries (24%) involved osteosynthesis material, including total joint arthroplasties. Read More

    Recent advances in polymer-based wound dressings for the treatment of diabetic foot ulcer: an overview of state-of-the-art.
    Curr Drug Targets 2017 Jul 4. Epub 2017 Jul 4.
    Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Raiwind Road Lahore, Punjab. Pakistan.
    Diabetic foot ulcers (DFUs) are the chronic, non-healing complications of diabetic mellitus which compels a significant burden to the patients and the healthcare system. Peripheral vascular disease, diabetic neuropathy, and abnormal cellular and cytokine/chemokine activity are among the prime players which exacerbate the severity and prevent wound reapir. Unlike acute wounds, DFUs impose a substantial challenge to the conventional wound dressings and demand the development of novel and advanced wound healing modalities. Read More

    Next Generation DNA Sequencing of Tissues from Infected Diabetic Foot Ulcers.
    EBioMedicine 2017 Jul 27;21:142-149. Epub 2017 Jun 27.
    Surgical Infection Research Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.
    We used next generation DNA sequencing to profile the microbiome of infected Diabetic Foot Ulcers (DFUs). The microbiota was correlated to clinical parameters and treatment outcomes to determine if directed antimicrobial therapy based on conventional microbiological cultures are relevant based on genomic analysis. Patients≥18years presenting with a new Diabetic Foot Infection (DFI) who had not received topical or oral antimicrobials in the two weeks prior to presentation, were eligible for enrolment. Read More

    All-cause and cardiovascular mortality in a consecutive series of patients with diabetic foot osteomyelitis.
    Diabetes Res Clin Pract 2017 Jun 15;131:12-17. Epub 2017 Jun 15.
    Diabetology - Azienda Ospedaliero Universitaria Careggi, Italy.
    Background: Mortality in patients with type 2 diabetes and diabetic foot osteomyelitis (DFO) have been explored in few small studies with a short follow-up. Aim of the present study is to assess all-cause and cardiovascular mortality and predictors of mortality in a consecutive series of patients with DFO.

    Research Design And Methods: Patients with a diagnosis of DFO, attending the Diabetic Foot Unit of San Donato Hospital in Arezzo between January 1st, 2012 and December 31st, 2013, were included in this retrospective study. Read More

    Early Use of Ceftaroline Fosamil in the United States Veterans Health Care System.
    Drugs 2017 Jun 29. Epub 2017 Jun 29.
    Pharmacotherapy Division, College of Pharmacy, The University of Texas at Austin, San Antonio, TX, USA.
    Background: Ceftaroline fosamil is US Food and Drug Administration-approved for acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia, but it is not known how ceftaroline is being used in real-world settings or how adverse effects (AEs) and mortality compare to clinical trials.

    Objective: This study describes ceftaroline use, AEs, and mortality in US Veterans Health Administration (VHA) hospital patients.

    Methods: This phase IV, population-based, epidemiologic study analyzed patients ≥18 years old who received one or more ceftaroline doses within 14 days of admission to 69 VHA hospitals in 41 US states/territories from 1 October 2010 to 30 September 2014. Read More

    A Retrospective Review of Adverse Events Related to Diabetic Foot Ulcers.
    Ostomy Wound Manage 2017 Jun;63(6):30-33
    James A. Haley Veterans' Hospital, Tampa, FL.
    The risk of adverse events (AEs) such as infection and amputation related to diabetic foot ulcers (DFUs) has been studied, but less is known about rate of other AEs such as falls. As part of a quality improvement project, AEs in veterans with diabetes mellitus (DM) with and without a DFU were examined. Demographic data including ICD-9 codes, AEs, and comorbidities for all patients with a diagnosis of DM and/or DFU treated between 2009 and 2014 at the James A. Read More

    Platelet-Rich Fibrin Accelerates Skin Wound Healing in Diabetic Mice.
    Ann Plast Surg 2017 Jun 23. Epub 2017 Jun 23.
    From the *Department of Plastic and Reconstructive Surgery, PLA Hospital of No. 117, Hangzhou; and †Department of Plastic Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, People's Republic of China.
    Diabetic foot ulcers (DFUs) are associated with an increased risk of secondary infection and amputation. Platelet-rich fibrin (PRF), a platelet and leukocyte concentrate containing several cytokines and growth factors, is known to promote wound healing. However, the effect of PRF on diabetic wound healing has not been adequately investigated. Read More

    Clinical profile and outcome of diabetic foot ulcer, a view from tertiary care hospital in Semarang, Indonesia.
    Diabet Foot Ankle 2017 17;8(1):1312974. Epub 2017 May 17.
    Resident of Internal Medicine, Medical Faculty of Diponegoro University, Dr. Kariadi General Hospital, Semarang, Indonesia.
    Background: This study attempted to determine the disease burden in terms of clinical profile and outcome of diabetic foot ulcer (DFU) admissions at a tertiary care hospital in a developing country. Methods: In this descriptive study, the data were collected from the medical record of diabetic patients with foot ulcer who were treated in Dr. Kariadi General Hospital during a 3-year period. Read More

    Microscopy visualisation confirms multi-species biofilms are ubiquitous in diabetic foot ulcers.
    Int Wound J 2017 Jun 23. Epub 2017 Jun 23.
    Surgical Infection Research Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.
    Increasing evidence within the literature has identified the presence of biofilms in chronic wounds and proposed that they contribute to delayed wound healing. This research aimed to investigate the presence of biofilm in diabetic foot ulcers (DFUs) using microscopy and molecular approaches and define if these are predominantly mono- or multi-species. Secondary objectives were to correlate wound observations against microscopy results in ascertaining if clinical cues are useful in detecting wound biofilm. Read More

    [Surgical treatment of diabetic neuroosteoarthropathy (DNOAP) and its long-term results].
    Khirurgiia (Mosk) 2017 (6):41-50
    Bryukhovetskaya Central Regional Hospital, Krasnodar Territory, Russia.
    Aim: To develop pathogenetically justified surgical treatment of diabetic neuroosteoarthropathy (DNOAP).

    Material And Methods: 52 patients were operated and long-term results were studied in 36 of them. 2 groups were assessed depending on completeness of surgical treatment including changed synovial structures removal. Read More

    Factors Predicting Length of Hospital Stay and Extended Care Facility Admission After Hindfoot Arthrodesis Procedures.
    J Foot Ankle Surg 2017 Jul - Aug;56(4):805-812
    Professor and Chair, Department of Orthopaedic Surgery, Sports Medicine and Rehabilitation, Boonshoft School of Medicine, Wright State University, Dayton, OH.
    Delayed identification of patients requiring admission to extended care facilities (ECFs) can lead to greater healthcare costs through an increased length of hospital stay (LOHS). Previous studies of hip and knee arthroplasty identified factors associated with a likely discharge to an ECF. These issues have not been extensively studied for major hindfoot procedures. Read More

    Clinical efficacy of piperacillin/tazobactam in the treatment of complicated skin and soft tissue infections.
    Expert Opin Pharmacother 2017 Jul 23;18(10):1027-1034. Epub 2017 Jun 23.
    a Department of Intensive Care Medicine , Kameda Medical Center , Kamogawa , Japan.
    Introduction: Complicated skin and soft tissue infections (cSSTIs) are skin and soft tissue infections (SSTIs) that involve deep soft tissue. cSSTIs often require surgical intervention and/or hospitalization. cSSTIs are associated with significant mortality and morbidity, and carry a significant burden on health care systems. Read More

    Real-Time Smart Textile-Based System to Monitor Pressure Offloading of Diabetic Foot Ulcers.
    J Diabetes Sci Technol 2017 Feb 1:1932296817695339. Epub 2017 Feb 1.
    3 South Arizona Limb Salvage Alliance (SALSA), University of Arizona College of Medicine, Tucson, AZ, USA.
    Background: The lifetime risk of developing a diabetic foot ulcer (DFU) is at least 25%. A DFU carries a 50% risk for infection and at least 20% of those receive some form of amputation. The most significant parameter that prevents or delays ulcer healing is high plantar pressure. Read More

    Frequency of Cutaneous Fungal Infections and Azole Resistance of the Isolates in Patients with Diabetes Mellitus.
    Adv Biomed Res 2017 6;6:71. Epub 2017 Jun 6.
    Department of Mycology and Parasitology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Diabetic patients are more susceptible to cutaneous fungal infections. The higher blood sugar levels cause increasing the cutaneous fungal infections in these patients. The main objective of this study was to find the frequency of fungal infections among cutaneous lesions of diabetic patients and to investigate azole antifungal agent susceptibility of the isolates. Read More

    Complications Following Operatively Treated Ankle Fractures in Insulin- and Non-Insulin-Dependent Diabetic Patients.
    Foot Ankle Spec 2017 Jun 1:1938640017714867. Epub 2017 Jun 1.
    UNC Orthopaedics, Chapel Hill, North Carolina.
    Background: Diabetics with ankle fractures experience more complications than the general population, but it is unclear whether complications differ between type 1 and 2 diabetics and between insulin- and non-insulin-dependent diabetics. This study aims to determine if there is a difference in postoperative complication rates between these groups.

    Methods: An administrative health care database from a large commercial insurer was queried to identify operatively treated ankle fractures in patients with type 1 (T1D), type 2 (T2D), type 2 insulin-dependent (T2ID), and type 2 non-insulin-dependent (T2NID) diabetes. Read More

    Topical antimicrobial agents for treating foot ulcers in people with diabetes.
    Cochrane Database Syst Rev 2017 06 14;6:CD011038. Epub 2017 Jun 14.
    Division of Nursing, Midwifery & Social Work, School of Health Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK, M13 9PL.
    Background: People with diabetes are at high risk for developing foot ulcers, which often become infected. These wounds, especially when infected, cause substantial morbidity. Wound treatments should aim to alleviate symptoms, promote healing, and avoid adverse outcomes, especially lower extremity amputation. Read More

    Depth and combined infection is important predictor of lower extremity amputations in hospitalized diabetic foot ulcer patients.
    Korean J Intern Med 2017 Jun 7. Epub 2017 Jun 7.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, St. Paul's Hospital, The Catholic University of Korea, Seoul, Korea.
    Background/aims: As the prevalence of diabetes mellitus and its complications increase rapidly, diabetic foot ulcers (DFUs), which are a major diabetic complication, are expected to increase. For prevention and effective treatment, it is important to understand the clinical course of DFUs. The aim of this study was to investigate the natural course and predictors of amputation in patients with DFUs who required hospitalization. Read More

    Silver-containing foam dressings with Safetac: a review of the scientific and clinical data.
    J Wound Care 2017 Jun;26(Sup6a):S1-S32
    Kristina Hamberg has over 10 years of experience of working with the design and development of wound care products, particularly those with antimicrobial properties. During that time, she has become an expert within the areas of microbiology and test method development, as well as infection prevention. Kristina was awarded her MSc in food science in 1997 from the University of Kalmar, Sweden, and in 2002 she was awarded a PhD for microbiological evaluation of novel technologies for food preservation by Chalmers Technical University, Gothenburg, Sweden.
    Background Topical antimicrobials, such as silver dressings, are progressively being used alongside systemic antibiotics to provide adjunctive, antimicrobial therapy to wounds that are clinically infected or at risk of infection. To help improve wound management, dressings that use Safetac soft silicone technology in combination with a silver-impregnated foam dressing material were developed by Mölnlycke Health Care (Gothenburg, Sweden). The range comprises Mepilex Ag, Mepilex Border Ag and Mepilex Transfer Ag. Read More

    Management of Osteomyelitis and Bone Loss in the Diabetic Charcot Foot and Ankle.
    Clin Podiatr Med Surg 2017 Jul 22;34(3):381-387. Epub 2017 Mar 22.
    Division of Podiatric Medicine and Surgery, Department of Orthopaedics, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, MSC 7776, San Antonio, TX 78229, USA. Electronic address:
    Bone loss and destruction due to diabetic Charcot neuroarthropathy (CN) and osteomyelitis of the foot and ankle is a challenging clinical condition when lower extremity preservation is considered. Resection and excision of osteomyelitis and associated nonviable soft tissue can lead into large osseous and soft tissue defects that will most likely need the utilization of bone grafting and subsequent arthrodesis for stability and anatomic alignment. In the diabetic population with peripheral neuropathy, osseous instability can lead to subsequent lower extremity deformity, ulceration, infection and/or amputation. Read More

    Isolation of bacteria from diabetic foot ulcers with special reference to anaerobe isolation by simple two-step combustion technique in candle jar.
    Indian J Med Res 2017 Jan;145(1):97-101
    Department of Microbiology, Institute of Post Graduate Medical Education & Research, Kolkata, India.
    Background & Objectives: Although polymicrobial infections involving both aerobic and anaerobic bacteria are very common in diabetic foot ulcers, in many centres of developing countries, anaerobes are rarely isolated due to technical difficulties. This can be overcome by using a new simple, innovative technique of a combination of candle combustion and use of acidified copper-coated steel wool, as reported here.

    Methods: In-house developed method was used in a prospective clinico-microbiological study for anaerobes from randomly selected 43 patients with diabetic foot ulcers along with conventional method of anaerobic culture in GasPak system and aerobic culture by standard laboratory procedures. Read More

    Clinical and Laboratory Profile of Urinary Tract Infections in Type 2 Diabetics Aged over 60 Years.
    J Clin Diagn Res 2017 Apr 1;11(4):OC25-OC28. Epub 2017 Apr 1.
    Senior Resident, Department of Internal Medicine, NRI Medical College, Guntur, Andhra Pradesh, India.
    Introduction: Urinary tract infections are frequently encountered among diabetic patients and the incidence rate increases with age. There have been growing research to identify the clinical profile of urinary tract infections in diabetic patients. However, such studies on elderly patients are rare. Read More

    [PERCUTANEOUS CORRECTION OF FOREFOOT DEFORMITIES IN DIABETIC PATIENTS IN ORDER TO PREVENT PRESSURE SORES - TECHNIQUE AND RESULTS IN 20 CONSECUTIVE PATIENTS].
    Harefuah 2017 Apr;156(4):234-236
    The Orthopedic Department, Hasharon Hospital, Rabin Medical Center, Petach Tikva, Israel affiliated with the Sackler Faculty of Medicine, Tel Aviv University.
    Introduction: Diabetes mellitus is a 21st century pandemic. Due to life-span prolongation combined with the increased rate of diabetes, a growing population of patients is afflicted with neuropathic foot deformities. Traditional operative repair of these deformities is associated with a high complication rate and relatively common infection incidence. Read More

    Diagnostic accuracy of various modalities relative to open bone biopsy for detection of long bone posttraumatic osteomyelitis.
    Eur J Orthop Surg Traumatol 2017 May 25. Epub 2017 May 25.
    Department of Orthopaedics, Denver Health Medical Center, School of Medicine, University of Colorado, 777 Bannock Street, Denver, CO, 80204, USA.
    Background: Long bone posttraumatic osteomyelitis (PTOM) is a relatively common complication following surgical fixation of open fractures. There is a lacking consensus on ideal strategies for diagnostic evaluation of long bone PTOM. While open bone biopsy and culture is considered the 'gold diagnostic standard,' its cost and invasiveness are often prohibitive and have prompted the search for alternate diagnostic methods. Read More

    Incidence and risk factors for developing infection in patients presenting with uninfected diabetic foot ulcers.
    PLoS One 2017 17;12(5):e0177916. Epub 2017 May 17.
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
    Objective: There is a paucity of research on patients presenting with uninfected diabetic foot ulcers (DFU) that go on to develop infection. We aimed to investigate the incidence and risk factors for developing infection in a large regional cohort of patients presenting with uninfected DFUs.

    Methods: We performed a secondary analysis of data collected from a validated prospective state-wide clinical diabetic foot database in Queensland (Australia). Read More

    Baroreceptor stimulation in a patient with preexisting subcutaneous implantable cardioverter defibrillator.
    Pacing Clin Electrophysiol 2017 May 24. Epub 2017 May 24.
    Division of Cardiology, Department of Internal Medicine I, University of Giessen, Giessen, Germany.
    Background: Many patients with severe heart failure (HF) have an indication for baroreflex activation therapy (BAT) and an implantable cardioverter-defibrillator (ICD). Concerns about device-device interactions were addressed in a study with small sample size that concluded combined BAT and ICD therapy is safe. There are no published data, however, concerning device-device interactions between BAT and a subcutaneous ICD (S-ICD). Read More

    [Total ankle arthroplasty with simultaneous subtalar fusion].
    Oper Orthop Traumatol 2017 Jun 18;29(3):194-206. Epub 2017 May 18.
    Fusschirurgie, Schulthess Klinik, Lengghalde 2, 8008, Zürich, Schweiz.
    Objective: Pain free weight bearing ability with orthograde hindfoot position and preserved tibiotalar motion.

    Indications: Symptomatic arthritis of the ankle and subtalar joint, additional subtalar hindfoot malalignment.

    Contraindications: Absolute: acute infection, noncorrectable ligamentous instability or bony defects, restricted perfusion, diabetic foot syndrome. Read More

    Amnion Membrane in Diabetic Foot Wounds: A Meta-analysis.
    Plast Reconstr Surg Glob Open 2017 Apr 25;5(4):e1302. Epub 2017 Apr 25.
    Tulane University School of Medicine, New Orleans, La.; Department of Surgery, Tulane University School of Medicine, New Orleans, La.; Department of Economics, Tulane University, New Orleans, La.; Thayer School of Engineering, Dartmouth College, Hanover, N.H.; and Department of Plastic & Reconstructive Surgery, Weill Cornell Medical College/Houston Methodist Hospital, Houston, Tex.
    Background: Amniotic membrane is tissue obtained from human placenta rich in cytokines, growth factors, and stem cells that possess the ability to inhibit infection, improve healing, and stimulate regeneration.

    Methods: A meta-analysis was performed examining randomized controlled trials comparing amniotic tissue products with standard of care in nonhealing diabetic foot ulcers including PubMed, Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews.

    Results: A search of 3 databases identified 596 potentially relevant articles. Read More

    Microbiological pattern of diabetic foot infections at a tertiary care center in a developing country.
    J Pak Med Assoc 2017 May;67(5):665-669
    Baqai Institute of Diabetology and Endocrinology, Baqai Medical University, Karachi.
    Objective: To determine the microbiological profile and antibiotic susceptibility patterns of organisms isolated from diabetic foot ulcers in a tertiary care hospital Karachi, Pakistan.

    Methods: This descriptive study was conducted at the Baqai Institute of Diabetology and Endocrinology (BIDE), from January 2013 to March 2014. Bone, pus and tissue samples were collected from 342 patients with diabetic foot infections and inoculated on appropriate media. Read More

    Novel Use of Active Leptospermum Honey for Ringed Fixator Pin Site Care in Diabetic Charcot Deformity Patients.
    Foot Ankle Spec 2017 May 1:1938640017709907. Epub 2017 May 1.
    Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina.
    Introduction: Open reduction with external fixation (OREF) utilizing fine wire ringed fixators for correction of Charcot deformity has gained popularity over the past decade. Pin site infections are a well-documented complication of external fixation as well as a driver of escalating health care costs. We aimed to demonstrate the safety and efficacy of a novel method of pin site care utilizing active Leptospermum honey-impregnated dressings (MediHoney) in diabetic patients undergoing deformity correction with OREF. Read More

    Anti-pseudomonal and anti-endotoxic effects of surfactin-stabilized biogenic silver nanocubes ameliorated wound repair in streptozotocin-induced diabetic mice.
    Artif Cells Nanomed Biotechnol 2017 May 14:1-12. Epub 2017 May 14.
    a Department of Microbiology, School of Life Sciences , Bharathidasan University , Tiruchirappalli , Tamil Nadu , India.
    Pseudomonas aeruginosa and its lipopolysaccharides play a key role in the pathogenesis of diabetic foot infection, for which, currently no effective therapeutic agents are available. Hence, newer forms of therapeutic agents are required for treating Pseudomonas aeruginosa infection. In this present study, nanocrystalline silver nanoparticles (AgNPs) were synthesized using culture filtrate of Brevibacillus brevis KN8(2) followed by an investigation of its in vivo anti-pseudomonal and anti-endotoxic properties. Read More

    Hospitalization for Charcot neuroarthropathy in diabetes: A population study in Italy.
    Diabetes Res Clin Pract 2017 Jul 28;129:25-31. Epub 2017 Apr 28.
    Diabetes Unit and Diabetes Foot Unit, San Jacopo Hospital, USL Centro-Toscana, Pistoia, Italy.
    Aims: To provide data on hospitalization and incidence rates of Charcot neuroarthropathy (CN) and its relation to lower limbs' amputations/revascularizations in population with diabetes of Italy as well as of one of its regions (Tuscany).

    Methods: Hospitalizations with CN diagnosis (codes ICD-9-CM: 7130, 7135, 7138) have been recorded in people with diabetes over years 2003-2013 in Italy and 2008-2015 in Tuscany. Amputations, peripheral vascular disease, revascularizations and infections were likewise evaluated. Read More

    Evaluation of diabetic foot infection in nuclear medicine.
    Q J Nucl Med Mol Imaging 2017 Sep 12;61(3):283-291. Epub 2017 May 12.
    Division of Nuclear Medicine, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    Diabetic foot infection is not only the most common cause of hospitalization among diabetic patients, but is also associated with high morbidity, mortality and major utilization of the resources. Managing diabetic patients with suspected foot infection is highly dependent on an early and accurate determination of its presence and location. Medical imaging is often used in the workup of these patients, as clinical diagnosis of osteomyelitis is often difficult, and invasive bone biopsy is infrequently used due to many limitations. Read More

    Renal function in patients with diabetic foot infection; does antibiotherapy affect it?
    J Renal Inj Prev 2017 25;6(2):117-121. Epub 2016 Nov 25.
    Infectious Diseases & Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran.
    Introduction: Antibiotic treatment (antibiotherapy) of diabetic foot ulcers has been proven to have toxic effect on renal function. Objectives: This study aimed to evaluate renal function in patients with diabetic foot infection. Patients and Methods: This cross-sectional retrospective study was performed on 142 patients with diabetic foot ulcers hospitalized in Shahid Yahyanejad hospital of Babol during 2013. Read More

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