3,610 results match your criteria Diabetic Foot Infections


Autoamputation of diabetic toe with dry gangrene: a myth or a fact?

Diabetes Metab Syndr Obes 2018 1;11:255-264. Epub 2018 Jun 1.

Division of Vascular Surgery, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Diabetes is associated with various complications and reduced quality of life. Of the many complications, some are life-threatening. Among these, foot complications remain an important concern. Read More

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Is it necessary to change instruments between sampling sites when taking multiple tissue specimens in musculoskeletal infections?

Ann R Coll Surg Engl 2018 Jun 18:1-3. Epub 2018 Jun 18.

Wirral University Teaching Hospital NHS Foundation Trust, Trauma and Orthopaedics , Wirral, Merseyside , UK.

Introduction Surgical debridement of orthopaedic infections allows biopsy for microbiology and facilitates successful treatment. It is recommended that biopsy instruments are changed when taking multiple samples. This study compared assessed cross-contamination between biopsy sites when using same instruments to take tissue samples from multiple sites. Read More

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Methicillin-resistant Staphylococcus aureus nasal carriage and infection among patients with diabetic foot ulcer.

J Microbiol Immunol Infect 2018 Jun 4. Epub 2018 Jun 4.

School of Medicine, Chang Gung University, Kweishan, Taoyuan, Taiwan; Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, Kweishan, Taoyuan, Taiwan. Electronic address:

Purpose: To evaluate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage in patients with diabetic foot ulcer (DFU) in Taiwan, and to assess the concordance between colonizing and clinical MRSA isolates from the patients.

Method: A total of 354 nasal specimens were collected from 112 to 242 diabetic patients with and without foot ulcer, respectively. MRSA clinical isolates from DFU wound cultures were collected for comparison. Read More

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June 2018
2 Reads

Long Non-Coding RNA CASC2 Improves Diabetic Nephropathy by Inhibiting JNK Pathway.

Exp Clin Endocrinol Diabetes 2018 Jun 11. Epub 2018 Jun 11.

Department of Endocrinology, Henan Provincial People's hospital, Zhengzhou City, Henan Province, PR. China.

It's known that long non-coding RNA CASC2 overexpression inhibit the JNK pathway in some disease models, while JNK pathway activation exacerbates diabetic nephropathy. Therefore we speculate that long non-coding RNA CASC2 can improve diabetic nephropathy by inhibiting JNK pathway. Thus, our study was carried out to investigate the involvement of CASC2 in diabetic nephropathy. Read More

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Diabetic foot ulcer outcomes from a podiatry led tertiary service in Kuwait.

Diabet Foot Ankle 2018 28;9(1):1471927. Epub 2018 May 28.

Clinical Research Unit, Medical Division, Dasman Diabetes Institute, Dasman, Kuwait.

: This single-centred study aims to evaluate the incidence, risk factors and treatment outcomes of a podiatry led, evidence-based diabetic foot ulcer (DFU) clinic. : Data from the DFU database and patient electronic health records were retrospectively collected from patients with new DFUs who were referred for treatment to the Department of Podiatry, Dasman Diabetes Institute, Kuwait, from 1 October 2014, to 31 December 2016. Patients were followed-up until healing occurred or until 6 months after the study end date, whichever came first. Read More

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May 2018
1 Read

Fat necrosis and polymicrobial wound infection caused partly by after reduction mammoplasty.

BMJ Case Rep 2018 Jun 4;2018. Epub 2018 Jun 4.

Division of Infectious Diseases, Department of Medicine, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA.

is a rare opportunistic aerobic gram-negative bacillus that naturally exists in soil, water and plants. The pathogen has been described in association with diabetic foot infections, biliary infections, bacteraemia and native and prosthetic joint infections. Fat necrosis and wound infection following breast reduction surgery or other plastic surgeries caused by this pathogen have not been previously described. Read More

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June 2018
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Role of anaerobes in polymicrobial communities and biofilms complicating diabetic foot ulcers.

Int Wound J 2018 Jun 4. Epub 2018 Jun 4.

Institute for Wound Research, Department Obstetrics & Gynaecology, University of Florida, Gainesville, Florida.

Infected tissues in the feet of people with diabetes in the form of a diabetic foot ulcer (DFU) present a complex pathology for clinicians to manage. This is partly attributed to the multi-factorial nature of the disease, which may include; altered foot architecture leading to excessive plantar pressures and frictional forces peripheral arterial disease and loss of protective sensation. In addition, to the above co-morbid variables, it is understood that a delayed wound healing state may be perpetuated by the presence of microorganisms residing in the wound tissue. Read More

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June 2018
1 Read

Exacerbated Foot Infections in Obese/Diabetic Mice Are Associated with Impaired Germinal Center Reactions, Ig Class Switching, and Humoral Immunity.

J Immunol 2018 Jun 1. Epub 2018 Jun 1.

Department of Pathology and Laboratory Medicine, University of Rochester, Rochester, NY 14642;

Obese patients with type 2 diabetes (T2D) are at an increased risk of foot infection, with impaired immune function believed to be a critical factor in the infectious process. In this study, we test the hypothesis that humoral immune defects contribute to exacerbated foot infection in a murine model of obesity/T2D. C57BL/6J mice were rendered obese and T2D by a high-fat diet for 3 mo and were compared with controls receiving a low-fat diet. Read More

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The Predictive Factors Associated With Comorbidities for Treatment Response in Outpatients With King Classification III Diabetes Foot Ulcers.

Ann Plast Surg 2018 May 30. Epub 2018 May 30.

Graduate Institute of Nursing, Chang Gung University of Science and Technology, Chiayi Campus, Taiwan.

Objective: The aim of this study is to investigate the preexisting predictive factors associated with comorbidities for diabetic foot ulcer (DFU) in King classification III at an outpatient clinic.

Method: This prospective study included 100 patients with DFU in King classification III treated at outpatient clinics in Chiayi Chang Gung Memorial Hospital from January 2011 to December 2011. The least follow-up time was 1 year. Read More

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May 2018
2 Reads

Human myiasis in patients with diabetic foot: 18 cases.

Ann Saudi Med 2018 May-Jun;38(3):208-213

Serhat Uysal, Infectious Diseases and Clinical Microbiology,, Ministry of Health, Republic of Turkey,, Seyfi Demirsoy State Hospital,, Infectious Diseases and Clinical Microbiology Service,, Diabetic Foot Clinic, Buca, Izmir, 35390, Turkey, T: 902-32425252, ORCID: http://orcid.org/0000-0002-4294.5999.

Background: Myiasis complication of diabetic foot ulcer has only been presented in a few case reports. Therefore, there is a need for additional data on this infestation.

Objective: Evaluate clinical characteristics of human myiasis in patients with diabetic foot. Read More

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June 2018
1 Read

Staphylococcus aureus requires less virulence to establish an infection in diabetic hosts.

Int J Med Microbiol 2018 May 22. Epub 2018 May 22.

Institute of Medical Microbiology, Jena University Hospital, Jena, Germany.

Staphylococcus aureus is the most frequent pathogen causing diabetic foot infections. Here, we investigated the degree of bacterial virulence required to establish invasive tissue infections in diabetic organisms. Staphylococcal isolates from diabetic and non-diabetic foot ulcers were tested for their virulence in in vitro functional assays of host cell invasion and cytotoxicity. Read More

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Diabetic foot management: multidisciplinary approach for advanced lesion's rescue.

J Cardiovasc Surg (Torino) 2018 May 29. Epub 2018 May 29.

Ortopedic Surgery, Foot & Ankle Clinic, Policlinico Abano Terme, Abano Terme, Padua, Italy.

Diabetic foot is a complication of diabetes affecting 15% of diabetics in their lives. It is associated to diabetic neuropathy and peripheral vascular disease and its incidence has increased. The ulceration is the initial cause of a dramatic process leading, if not correctly treated, to amputations. Read More

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Diabetic foot infection: A critical complication.

Int Wound J 2018 May 28. Epub 2018 May 28.

Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

The number of people in the world with diabetes has nearly quadrupled in the past 40 years. Current data show that 25% of these diabetics will develop a foot ulcer in their lifetime and that the cost of care for a diabetic foot ulcer (DFU) is over twice that of any other chronic ulcer aetiology. Microbial biofilm has been linked to both wound chronicity and infection. Read More

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May 2018
1 Read

The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification system predicts wound healing better than direct angiosome perfusion in diabetic foot wounds.

J Vasc Surg 2018 May 23. Epub 2018 May 23.

Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Md; Diabetic Foot and Wound Service, The Johns Hopkins Hospital, Baltimore, Md. Electronic address:

Objective: Previous studies show conflicting results in wound healing outcomes based on angiosome direct perfusion (DP), but few have adjusted for wound characteristics in their analyses. We have previously shown that the Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification correlates with wound healing in diabetic foot ulcers (DFUs) treated by a multidisciplinary team. The aim of this study was to compare WIfI classification vs DP and pedal arch patency as predictors of wound healing in patients presenting with DFU and peripheral arterial disease. Read More

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Short-term predictors of amputation in patients with diabetic foot ulcers.

Diabetes Metab Syndr 2018 May 17. Epub 2018 May 17.

Division of Endocrinology, Diabetes and Metabolism, Centro Hospitalar do Porto, Portugal.

Background: Diabetic foot ulcers are the leading cause of non-traumatic lower extremity amputation. The aim of this study was to establish short-term predictors of lower extremity amputation (LEA) in patients with diabetic foot ulcers (DFU).

Methods: A retrospective observational study was performed. Read More

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Polymicrobial interactions influence the agr copy number in Staphylococcus aureus isolates from diabetic foot ulcers.

Antonie Van Leeuwenhoek 2018 May 23. Epub 2018 May 23.

Interdisciplinary Centre of Research in Animal Health (CIISA)/Faculty of Veterinary Medicine, University of Lisbon, Avenida da Universidade Técnica, 1300-477, Lisbon, Portugal.

Diabetic foot ulcers are a major complication of diabetes and are often colonised by complex bacterial communities, where Staphylococcus aureus is frequently co-present with Pseudomonas aeruginosa. These bacteria interact through quorum sensing, encoded in S. aureus by the accessory gene regulator (agr). Read More

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Understanding the microbiome of diabetic foot osteomyelitis: insights from molecular and microscopic approaches.

Clin Microbiol Infect 2018 May 19. Epub 2018 May 19.

Infectious Diseases and Microbiology, School of Medicine, Western Sydney University, Australia; Liverpool Hospital, South Western Sydney LHD, Sydney, Australia; Liverpool Diabetes Collaborative Research Unit, Ingham Institute of Applied Medical Research, Sydney, Australia. Electronic address:

Objectives: Rigorous visual evidence on whether or not biofilms are involved in diabetic foot osteomyelitis (DFO) is lacking. We employed a suite of molecular and microscopic approaches to investigate the microbiome, and phenotypic state of microorganisms involved in DFO.

Methods: In 20 consecutive subjects with suspected DFO, we collected intraoperative bone specimens. Read More

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May 2018
1 Read

A randomized controlled trial of the safety and efficacy of a topical gentamicin-collagen sponge in diabetic patients with a mild foot ulcer infection.

SAGE Open Med 2018 13;6:2050312118773950. Epub 2018 May 13.

Service of Infectious Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Objectives: The initial phase of infection of a foot ulcer in a person with diabetes is often categorized as mild. Clinicians usually treat these infections with antimicrobial therapy, often applied topically. Some experts, however, believe that mild diabetic foot ulcer infections will usually heal with local wound care alone, without antimicrobial therapy or dressings. Read More

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Association between VEGF genetic variants and diabetic foot ulcer in Chinese Han population: A case-control study.

Medicine (Baltimore) 2018 May;97(20):e10672

Department of Hand and Foot Microsurgery Surgery, First Hospital of Ningbo, China.

The aim of this study was to investigate the association of vascular endothelial growth factor (VEGF) gene polymorphisms with diabetic foot ulcer (DFU) susceptibility in a Chinese Han population.Around 88 type 2 diabetes mellitus (T2DM) patients without DFU and 97 T2DM patients with DFU were enrolled in this study. A total of 103 age and gender matched healthy individuals were recruited as healthy control. Read More

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Carbapenem-susceptible Escherichia coli ST3901 carrying mcr-1 and bla genes isolated from a diabetic foot infection in Brazil.

J Glob Antimicrob Resist 2018 Jun 25;13:209-210. Epub 2018 May 25.

Department of Pathology, Center of Health Sciences, Federal University of Espírito Santo, Vitória, Brazil; Post-Graduate Program in Infectious Diseases, Federal University of Espírito Santo, Vitória, Brazil. Electronic address:

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Clinico-microbiological Profile of Septic Diabetic Foot with Special Reference to Anaerobic Infection.

Cureus 2018 Mar 1;10(3):e2252. Epub 2018 Mar 1.

Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

Introduction Diabetic foot infections are a major cause of non-traumatic amputations. The role of anaerobes in the prognosis of these infections is particularly unclear. This study was conducted with the aim of correlating microbiological profiles with clinical outcomes in these diabetic foot ulcer patients. Read More

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A Post-marketing Surveillance Study of Chronic Wounds Treated With a Native Collagen Calcium Alginate Dressing.

Ostomy Wound Manage 2018 Apr;64(4):38-43

SerenaGroup®, Cambridge, MA.

Chronic wounds (ie, wounds that fail to progress through a normal, orderly, timely sequence of repair) continue to pose significant clinical and economic burdens. A prospective, descriptive, 3-week post-marketing surveillance study was conducted across 3 wound care centers in the United States to evaluate the effectiveness of a collagen calcium alginate dressing on chronic wounds in conjunction with standard care (SC) practices (eg, offloading, debridement, compression) to support healing. Eligible participants had to be >18 years of age, have at least 1 chronic wound, and no known sensitivity to collagen. Read More

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Hand infection in patients with diabetes: a series of 17 cases and a pooled analysis of the literature

Turk J Med Sci 2018 Apr 30;48(2):372-377. Epub 2018 Apr 30.

Background/aim: The aim of this study was to report the clinical characteristics and the treatment outcomes of hand infections in diabetic patients and to review the literature. Materials and methods: The medical records of 17 patients with diabetic hand infections admitted to the Diabetic Foot Care Center of two different clinics from January 2012 to October 2017 were reviewed. To perform the pooled analysis, published series (32 studies) were searched in two international databases (www. Read More

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April 2018
2 Reads

Follow up of MRI bone marrow edema in the treated diabetic Charcot foot - a review of patient charts.

Diabet Foot Ankle 2018 26;9(1):1466611. Epub 2018 Apr 26.

Department of Diagnostic and Interventional Radiology, HELIOS University Hospital Wuppertal, University Witten/Herdecke, Wuppertal, Germany.

: Ill-defined areas of water-like signal on bone magnetic resonance imaging (MRI), characterized as bone marrow edema or edema-equivalent signal-changes (EESC), is a hallmark of active-stage pedal neuro-osteoarthropathy (Charcot foot) in painless diabetic neuropathy, and is accompanied by local soft-tissue edema and hyperthermia. The longitudinal effects on EESC of treating the foot in a walking cast were elucidated by reviewing consecutive cases of a diabetic foot clinic. : Retrospective observational study, chart review : Cases with active-stage Charcot foot were considered, in whom written reports on baseline and follow-up MRI studies were available for assessment. Read More

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Platelet-rich plasma as an additional therapeutic option for infected wounds with multi-drug resistant bacteria: in vitro antibacterial activity study.

Eur J Trauma Emerg Surg 2018 Apr 26. Epub 2018 Apr 26.

Department of War Surgery, Gulhane Training and Research Hospital, Ankara, Turkey.

Purpose: Infected wounds, such as diabetic foot infections, are mostly polymicrobial and microorganisms have high resistance rates to antimicrobials. Infected wounds in diabetic patients have high cost, morbidity, and mortality rates. Based on these facts, there is a need for supportive localized treatment options such as platelet-rich plasma (PRP) implementations. Read More

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April 2018
2 Reads

Barriers to foot care in patients with diabetes as identified by healthcare professionals.

Diabet Med 2018 Apr 26. Epub 2018 Apr 26.

King's College Hospital NHS Foundation Trust, London, UK.

Aims: To seek the views of healthcare professionals as to the barriers to foot care that they perceive as having an impact on clinical outcomes and contributing to the number of amputations.

Methods: The study involved healthcare professionals from the UK attending our 2015 and 2016 Masterclass diabetic foot conferences. Admission to these conferences was open to all members of the multidisciplinary spectrum who provide care of people with diabetes and foot problems. Read More

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Use of Leukocyte Platelet (L-PRF) Rich Fibrin in Diabetic Foot Ulcer with Osteomyelitis (Three Clinical Cases Report).

Diseases 2018 Apr 24;6(2). Epub 2018 Apr 24.

Faculty of Medicine and Surgery, Vasile Goldis Western University of Arad, 310025 Arad, Romania.

In this study, the use of fibrin rich in leukocytes and platelets (L-PRF) was explored to heal osteomyelitis ulcers in a diabetic foot. The goal was to standardize the utilization of L-PRF in patients with osteomyelitis to direct it for healing. L-PRF was obtained autologously from the peripheral blood of the diabetic patients ( = 3) having osteomyelitis and skin lesions for at least six months. Read More

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April 2018
4 Reads

The Clinical Value of Diffusion Weighted Magnetic Resonance Imaging in Diabetic Foot Infection.

J Am Podiatr Med Assoc 2018 Apr 24. Epub 2018 Apr 24.

¶ Harran University.

Background: Osteomyelitis is a common complication in the diabetic foot which can be concluded with amputation. The purpose of this study was to evaluate the role of diffusion-weighted MRI (DWI) in the diagnosis of osteomyelitis in the diabetic foot ulcer (DFU).

Methods: Thirty patients with type 2 diabetes mellitus having DFU were enrolled. Read More

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Effectiveness of viable cryopreserved placental membranes for management of diabetic foot ulcers in a real world setting.

Wound Repair Regen 2018 Apr 23. Epub 2018 Apr 23.

Osiris Therapeutics, Inc., Columbia, Maryland.

In a multicenter randomized controlled trial (RCT), the use of viable cryopreserved placental membrane (vCPM) for chronic diabetic foot ulcers (DFUs) resulted in a higher proportion of wound closure in comparison to good wound care: 62% versus 21% (p < 0.01). However, patients in RCTs are not representative of daily physician practice. Read More

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April 2018
3 Reads

The Role of Serum Procalcitonin, Interleukin-6, and Fibrinogen Levels in Differential Diagnosis of Diabetic Foot Ulcer Infection.

J Diabetes Res 2018 21;2018:7104352. Epub 2018 Feb 21.

Department of Clinical Microbiology and Infectious Diseases, Dumlupınar University Faculty of Medicine, 43020 Kutahya, Turkey.

Aims: We aimed to evaluate the roles of interleukin-6 (IL-6), PCT, and fibrinogen levels in the differential diagnosis of the patients with infected diabetic foot ulcer (IDFU) and noninfected diabetic foot ulcer (NIDFU) and to compare those with C-reactive protein (CRP), white blood cell (WBC), and erythrocyte sedimentation rate (ESR).

Methods: Patients over 18 years with a diagnosis of type 2 diabetes mellitus and DFU who were followed up in our hospital between 1 January 2016 and 1 January 2017 were included in the study. In addition to this patient group, patients with diabetes but without DFU were determined as the control group. Read More

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February 2018
1 Read

Contemporary critical limb ischemia: Asian multidisciplinary consensus statement on the collaboration between endovascular therapy and wound care.

Cardiovasc Interv Ther 2018 Apr 13. Epub 2018 Apr 13.

Department of Surgery, Keio University School of Medicine, Tokyo, Japan.

The burden of peripheral artery disease (PAD) and diabetes in Asia is projected to increase. Asia also has the highest incidence and prevalence of end-stage renal disease (ESRD) in the world. Therefore, most Asian patients with PAD might have diabetic PAD or ESRD-related PAD. Read More

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April 2018
1 Read

Managing diabetic foot infections: a survey of Australasian infectious diseases clinicians.

J Foot Ankle Res 2018 10;11:13. Epub 2018 Apr 10.

19School of Clinical Sciences, Queensland University of Technology, Victoria Park Rd, Kelvin Grove, QLD Australia.

Background: Diabetic foot infections (DFI) present a major morbidity, mortality and economic challenge for the tertiary health sector. However, lack of high quality evidence for specific treatment regimens for patients with DFIs may result in inconsistent management. This study aimed to identify DFI caseload proportion and patterns of clinical practice of Infectious Diseases (ID) Physicians and Trainees within Australia and New Zealand. Read More

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April 2018
1 Read

Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model.

Exp Mol Med 2018 Apr 13;50(4):29. Epub 2018 Apr 13.

Department of Interventional & Vascular Surgery, Tenth People's Hospital of Tongji University, No. 301 Middle Yan Chang Road, Shanghai, 200072, China.

Diabetic foot ulcers (DFU) increase the risks of infection and amputation in patients with diabetes mellitus (DM). The impaired function and senescence of endothelial progenitor cells (EPCs) and high glucose-induced ROS likely exacerbate DFUs. We assessed EPCs in 60 patients with DM in a hospital or primary care setting. Read More

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Prospective Analysis of Surgical Bone Margins After Partial Foot Amputation in Diabetic Patients Admitted With Moderate to Severe Foot Infections.

Foot Ankle Spec 2018 Apr 1:1938640018770285. Epub 2018 Apr 1.

Division of Metabolism, Endrocrinology, and Diabetes, Department of Internal Medicine, Ann Arbor, Michigan (BMS, JSM).

Background: Osteomyelitis is common in diabetic foot infections and medical management can lead to poor outcomes. Surgical management involves sending histopathologic and microbiologic specimens which guides future intervention. We examined the effect of obtainment of surgical margins in patients undergoing forefoot amputations to identify patient characteristics associated with outcomes. Read More

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Microbiology and Antimicrobial Therapy for Diabetic Foot Infections.

Infect Chemother 2018 Mar;50(1):11-20

Southwestern Academic Limb Salvage Alliance (SALSA), Department of Surgery of Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

In addition to being the prime factor associated with amputation, diabetic foot infections (DFIs) are associated with major morbidity, increasing mortality, and reduced quality of life. The choice of appropriate antibiotics is very important in order to reduce treatment failure, antimicrobial resistance, adverse events, and costs. We reviewed articles on microbiology and antimicrobial therapy and discuss antibiotic selection in Korean patients with DFIs. Read More

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March 2018
3 Reads

Bone and joint infection.

Clin Med (Lond) 2018 Mar;18(2):150-154

Nuffield Orthopaedic Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK

Bone and joint infections include septic arthritis, prosthetic joint infections, osteomyelitis, spinal infections (discitis, vertebral osteomyelitis and epidural abscess) and diabetic foot osteomyelitis. All of these may present through the acute medical take. This article discusses the pathogenesis of infection and highlights the importance of taking a careful history and fully examining the patient. Read More

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March 2018
1 Read

The Society for Vascular Surgery Wound, Ischemia, and foot Infection (WIfI) classification independently predicts wound healing in diabetic foot ulcers.

J Vasc Surg 2018 Apr 2. Epub 2018 Apr 2.

Diabetic Foot and Wound Service, The Johns Hopkins Hospital, Baltimore, Md; Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Md. Electronic address:

Objective: Previous studies have reported correlation between the Wound, Ischemia, and foot Infection (WIfI) classification system and wound healing time on unadjusted analyses. However, in the only multivariable analysis to date, WIfI stage was not predictive of wound healing. Our aim was to examine the association between WIfI classification and wound healing after risk adjustment in patients with diabetic foot ulcers (DFUs) treated in a multidisciplinary setting. Read More

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April 2018
4 Reads

Managing the Diabetic Foot Ulcer: How Best Practices Fit the Real 2018 United States.

Surg Technol Int 2018 Jun;32:49-59

Vice Chairman of General Surgery, Director of Surgical Clinical Research, Mount Sinai St. Luke's - West Hospitals, New York, New York.

Diabetes Mellitus is a serious systemic illness that has an epidemic-like increasing prevalence in the United States, as well as the rest of the world. With the increasing number of people with diabetes comes the higher incidence of diabetes-related complications. One of these known complications, diabetic foot ulcers (DFU), has an estimated lifetime incidence of 15% in diabetics. Read More

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Improvement in Quality of Life Following Operative Correction of Midtarsal Charcot Foot Deformity.

Foot Ankle Int 2018 Mar 1:1071100718762138. Epub 2018 Mar 1.

1 Department of Orthopaedic Surgery & Rehabilitation, Loyola University Health System, Maywood, IL, USA.

Background: Patients with Charcot foot arthropathy report a poor quality of life following the development of deformity. Their quality of life is often not improved with "successful" historic accommodative treatment. There is increased current interest in operative correction of the acquired deformity with the stated goals of achieving both the traditional goals of resolution of infection and limb salvage as well as the desire to improve quality of life. Read More

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A Perioperative Approach to Increase Limb Salvage When Treating Foot Ulcers in Patients With Diabetes.

AORN J 2018 Apr;107(4):431-440

Foot ulceration in patients with diabetes increases the risk of lower extremity amputation. Major amputations produce substantial adverse consequences, increase length of hospital stay, diminish quality of life, and increase mortality. In this article, we describe approaches that decrease amputations and improve the quality of life for patients with diabetes and foot ulcers. Read More

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April 2018
3 Reads

Burn aggravated infected wart in a patient with type 2 diabetes: a medical challenge.

BMJ Case Rep 2018 Mar 28;2018. Epub 2018 Mar 28.

Department of Pharmaceutics, Hamdard University, Karachi, Pakistan.

An infectious wart of foot in a patient with diabetics is a medical challenge, and it gets worse when aggravated with burns. We present a case of a 67-year-old Pakistani man, diabetic for 20 years presented at our healthcare centre. While awaiting his culture sensitivity report, he was prescribed an empiric antibiotic therapy. Read More

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March 2018
1 Read

Molecular and culture based assessment of bacterial pathogens in subjects with diabetic foot ulcer.

Diabetes Metab Syndr 2018 May 16;12(3):417-421. Epub 2018 Mar 16.

Rajiv Gandhi Centre for Diabetes and Endocrinology, J.N Medical College, Aligarh Muslim University, Aligarh, U.P, 202002, India. Electronic address:

Introduction: Expeditious and precise discerning of bacterial pathogens is a fundamental grail, of clinical diagnostic microbiology. Genotypic detection is a budding substitute to recognize phenotypic culture based processes in bacterial identification.

Aims: We report a comparative evaluation of biochemical and genomic-based assays for exploring the commonest bacterial flora of infected diabetic foot ulcers along with clinical variables of subjects enrolled. Read More

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Minimal Invasive Fixation Can Decrease Infection Rates in Diabetic and Obese Patients With Severe Ankle Fracture and Syndesmotic Injury.

Foot Ankle Spec 2018 Mar 1:1938640018766627. Epub 2018 Mar 1.

Department of Orthopaedic Surgery, University of Toledo Medical Center, Toledo, Ohio.

Background: Ankle fractures involving syndesmosis disruption cause severely unstable joint conditions. Traditional invasive operations put certain patient groups at an increased risk of infection. There is limited literature discussing the outcomes of minimally invasive fixation of severe ankle fractures including syndesmotic injury, as clinicians may be tempted to treat these difficult cases with open reduction internal fixation (ORIF). Read More

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March 2018
1 Read

Virulence Factor Genes in Staphylococcus aureus Isolated From Diabetic Foot Soft Tissue and Bone Infections.

Int J Low Extrem Wounds 2018 Mar 22;17(1):36-41. Epub 2018 Mar 22.

5 University of Washington, Seattle, WA, USA.

The aim of this study is to describe the presence of genes encoding for 4 virulence factors (pvl, eta, etb, and tsst), as well as the mecA gene conferring resistance to beta-lactam antibiotics, in patients with diabetes and a staphylococcal foot infection. We have also analyzed whether isolates of Staphylococcus aureus from bone infections have a different profile for these genes compared with those from exclusively soft tissue infections. In this cross-sectional study of a prospectively recruited series of patients admitted to the Diabetic Foot Unit, San Juan de Dios Hospital, San José, Costa Rica with a moderate or severe diabetic foot infection (DFI), we collected samples from infected soft tissue and from bone during debridement. Read More

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Effects of pH on the Antibiotic Resistance of Bacteria Recovered from Diabetic Foot Ulcer Fluid .

J Am Podiatr Med Assoc 2018 Jan;108(1):6-11

Background: This study investigated the resistance of bacteria isolated from diabetic foot ulcers (DFUs) to antibiotics frequently used in the management of the diabetic foot infections, at a range of pH values (pH 6.5, 7.5, and 8. Read More

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January 2018

New insights into classification, epidemiology and microbiology of SSTIs, including diabetic foot infections.

Infez Med 2018 Mar;26(1):3-14

Department of Hygiene, University of Salerno, Italy.

Skin and soft tissue infections (SSTIs) involve a heterogeneous group of entities with different clinical presentations classified according to several specific criteria. Because of their great variability, their incidence and prevalence is difficult to accurately determine. Yet it is generally thought that the rate of SSTIs is globally increasing due to an aging population, strictly associated with the increase in the number of critical and immunocompromised patients. Read More

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Computerized planimetry evaluation of hyperbaric oxygen therapy in the treatment of diabetic foot.

Adv Clin Exp Med 2018 Jan;27(1):39-44

Centre for Burns Treatment, Siemianowice Śląskie, Poland.

Background: Diabetic foot ulcer is one of the major complications of diabetes mellitus in adults.

Objectives: The aim of the study was to conduct a planimetry evaluation of the effectiveness of hyperbaric oxygen therapy (HBOT) in the treatment of patients with vascular disorders caused by diabetic foot.

Material And Methods: The study included 94 patients, 30 females (32%) and 64 males (68%), aged 33-76 years, with diabetes lasting 1. Read More

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January 2018

Pseudomonas aeruginosa infection alters the macrophage phenotype switching process during wound healing in diabetic mice.

Cell Biol Int 2018 Jul 14;42(7):877-889. Epub 2018 Mar 14.

Shanghai Tenth People's Hospital and Department of Regenerative Medicine, Tongji University School of Medicine, Shanghai, China.

Macrophages play critical roles in wound healing process. They switch from "classically activated" (M1) phenotype in the early inflammatory phase to "alternatively activated" (M2) phenotype in the later healing phase. However, the dynamic process of macrophage phenotype switching in diabetic wounds burdened with bacteria is unclear. Read More

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July 2018
7 Reads

An Overview on Diabetic foot Infections, including Issues Related to Associated Pain, Hyperglycemia and Limb Ischemia.

Curr Pharm Des 2018 Mar 2. Epub 2018 Mar 2.

Service of Infectious Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Switzerland.

Factors strongly related to the risk of developing diabetic foot infections include vascular, neuropathic and hyperglycemic complications of long-standing diabetes mellitus. These infections are common and serious, posing a worldwide burden on administrative providers of healthcare, patients and physicians. The most appropriate approach to these infections is with a multidisciplinary team. Read More

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March 2018
11 Reads

Reconstruction of diabetic lower leg and foot soft tissue defects using thoracodorsal artery perforator chimeric flaps.

Microsurgery 2018 Mar 5. Epub 2018 Mar 5.

Department of Plastic and Reconstructive Surgery, College of Medicine, Seoul National University, Seoul National University Hospital, Seoul, Korea.

Background: Reconstruction of complicated diabetic lower leg and foot defects involving multiple tissue components remains a challenge. The purpose of this report is to introduce thoracodorsal artery perforator (TDAP) chimeric flaps for reconstructing diabetic lower leg and foot soft tissue defects.

Patients And Methods: Between April 2010 and August 2016, 17 patients with multiple diabetic lower leg and foot defects underwent reconstruction with TDAP chimeric flaps. Read More

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March 2018
1 Read