6,837 results match your criteria Diabetes research and clinical practice[Journal]


Efficacy and Safety of an Albiglutide Liquid Formulation Compared With the Lyophilized Formulation: A 26-Week Randomized, Double-Blind, Repeat-Dose Study in Patients With Type 2 Diabetes Mellitus.

Diabetes Res Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Clinical Development, GlaxoSmithKline, Collegeville, PA, USA.

Aims: Compare the efficacy and safety of albiglutide from a ready-to-use, single-dose, auto-injector system with the lyophilized product in patients with type 2 diabetes mellitus (T2DM).

Methods: In this phase 3 study, 308 patients between 18 and 80 years with T2DM and experiencing inadequate glycemic control on their current regimen of diet/exercise alone or in combination with metformin were randomized 1:1 to weekly injections for 26 weeks with an active albiglutide auto-injector and placebo lyophilized dual-chamber cartridge (DCC) pen injector (n=154) or active albiglutide lyophilized DCC pen injector and placebo liquid auto-injector (n=154). Participants received liquid or lyophilized albiglutide 30 mg for 4 weeks, and then 50 mg for the remaining 22 weeks. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.018DOI Listing
April 2019
1 Read

Standard complication screening information can be used for risk assessment for first time foot ulcer among patients with type 1 and type 2 diabetes.

Diabetes Res Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Steno Diabetes Center Copenhagen, Niels Steensensvej 2, 2820 Gentofte, Denmark; Department of Dermatology and Copenhagen Woundhealing Center, Copenhagen Wound Healing Center, Copenhagen University Hospital Bispebjerg, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark.

Aim: Diabetic foot ulcer (DFU) is a major complication of both Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D); however research into risk factors for DFU does not separate between these two types. The purpose of the present investigation was to identify risk factors for development of first time DFU (FTDFU) over a period of 15 years in patients with T1D and T2D separately.

Methods: This retrospective cohort study included 25220 feet from 5588 patients with T1D and 7113 patients with T2D treated in the period 2001 to 2015. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.021DOI Listing

Detecting the hidden burden of pre-diabetes and diabetes in Western Sydney.

Diabetes Res Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Western Sydney Local Health District; University of Western Sydney; School of Public Health, Peking Union Medical College, Tsinghua University and the Chinese Academy of Medical Sciences.

Aims: Examining pre-diabetes and diabetes rates using glycated haemoglobin (HbA) in emergency department (ED) and in general practice (GP) in western Sydney.

Methods: Epidemiological study of HbA1c measurements in individuals ≥ 18 years receiving a blood test (1) in the hospital setting of the ED at Blacktown/Mt Druitt hospital (1/06/2016 to 31/05/2018) and (2) in primary care involving Bridgeview Medical Practice (BVMP) (1/03/2017 to 01/02/2018) as well as other general practices (June 2018 only).

Results: Totals of 55,568 individuals from ED and 5,911 individuals from GP. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.019DOI Listing

Circulating neuromedin U levels are similar in subjects with NGT and newly diagnosed T2DM and do not correlate with insulin secretion.

Diabetes Res Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Department of Endocrinology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China. Electronic address:

Aims: Neuromedin U (NMU), a highly conserved peptide, is implicated in energy homeostasis and is involved in regulating insulin secretion as a decretin hormone in animals. However, there have been no reports on the relationship between NMU and type 2 diabetes mellitus (T2DM). The aim of this study was to investigate circulating NMU concentrations in healthy subjects and T2DM patients and to evaluate the association between serum NMU levels and glucose-stimulated insulin secretion. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.020DOI Listing

Cardiac syncope recurrence in type 2 diabetes mellitus patients vs. normoglycemics patients: the CARVAS study.

Diabetes Res Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy. Electronic address:

Study hypothesis cardiac autonomic dysfunction might lead to higher vaso vagal syncope (VVS) recurrence rate in type 2 diabetes mellitus (T2DM) patients vs. non diabetics patients.

Background: VVS recurrence might be due to alterations of autonomic system function, as assessed by heart rate variability (HRV). Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.015DOI Listing

Effect of postpartum glucose tolerance results on subsequent weight retention in women with recent gestational diabetes: a retrospective cohort study.

Diabetes Res Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Women's College Research Institute, Women's College Hospital, Toronto, Canada; Institute of Health Policy, Management and Evaluation/Dalla Lana School of Public Health, University of Toronto, Toronto, Canada; Department of Medicine, University of Toronto, Toronto, Canada; Institute for Clinical Evaluative Sciences, Toronto, Canada; Sunnybrook Health Sciences Centre, Toronto, Canada. Electronic address:

Aims: Glucose tolerance normalizes postpartum in most women with gestational diabetes (GDM), which may provide false reassurance and decrease weight-reducing behaviours. We evaluated whether awareness of normal postpartum glucose tolerance was associated with higher weight retention than being unaware of glucose tolerance.

Methods: This cohort study of women with GDM collected survey data during pregnancy and in the first and second postpartum year. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.016DOI Listing

The Number of Adults with Incident Type 1 Diabetes Phenotype in Iceland is Half the Number in Children - a Population Based Study.

Diabetes Res Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Department of Endocrinology, Landspitali, The National University Hospital of Iceland, Fossvogur, 108 Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Vatnsmyrarvegur 16, 101 Reykjavik, Iceland.

Aims: Type1 diabetesis generally regarded as an abruptly presenting disease in children without family history. The incidence and prevalence of insulin requiring diabetes in adults is unclear. The aim of this study was to clarify this issue by examining the epidemiology of type 1 diabetes diagnosed in adulthoodin a countrýs whole population. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.023DOI Listing

Design and Development of the Hypoglycaemia Symptom Rating Questionnaire (HypoSRQ).

Diabetes Res Clin Pract 2019 Apr 5. Epub 2019 Apr 5.

Health Psychology Research Unit., Orchard Building, Royal Holloway, University of London, Egham, Surrey, TW20 0EX, UK; Health Psychology Research Ltd., Orchard Building, Royal Holloway, University of London, Egham, Surrey, TW20 0EX, UK. Electronic address: http://www.healthpsychologyresearch.com.

Aims: To evaluate the Hypoglycaemia Symptom Rating Questionnaire (HypoSRQ) and relationships between self-reported hypoglycaemia and hypoglycaemia measured using blinded continuous glucose monitoring (CGM).

Methods: Diabetes outpatients (n=113) recruited from Ashford and St. Peter's Hospital completed the HypoSRQ (recent weeks version) and provided clinical information. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.010DOI Listing
April 2019
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Are gliflozins the new statins for diabetes?

Diabetes Res Clin Pract 2019 Apr 5. Epub 2019 Apr 5.

Diabetes Unit, Department of Advanced Medical and Surgical Sciences, Università L. Vanvitelli, Naples, Italy.

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http://dx.doi.org/10.1016/j.diabres.2019.04.014DOI Listing

Levels of personality functioning and not depression predict decline of plasma glucose concentration in patients with type 2 diabetes mellitus.

Diabetes Res Clin Pract 2019 Apr 5;151:106-113. Epub 2019 Apr 5.

Department of Psychosomatics and Psychotherapy, University Hospital Münster, Münster, Germany. Electronic address:

Aims: Psychosocial variables influence chronic diseases, such as type 2 diabetes mellitus. While there is evidence for a negative impact of depression, much less is known about stable, personality oriented factors. Aim of the study was to assess the impact of depression and personality functioning on glucose regulation in patients with type 2 diabetes. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.011DOI Listing

Mean platelet volume predicts survival in patients with hepatocellular carcinoma and type 2 diabetes.

Diabetes Res Clin Pract 2019 Apr 5;151:120-127. Epub 2019 Apr 5.

Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, China. Electronic address:

Background: Patients with hepatocellular carcinoma (HCC) having pre-existing type 2 diabetes (T2DM) have a poorer prognosis than those without T2DM. Moreover, accumulating evidence reveals that activated platelets play a crucial role in tumor and T2DM. The mean platelet volume (MPV) indicates platelet activation and is altered in malignancies. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.012DOI Listing

Flash glucose monitoring for the safe use of a 2-day intermittent energy restriction in patients with type 2 diabetes at risk of hypoglycaemia: An exploratory study.

Diabetes Res Clin Pract 2019 Apr 5;151:138-145. Epub 2019 Apr 5.

School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia; Alliance for Research in Exercise, Nutrition and Activity, University of South Australia, Adelaide, South Australia, Australia.

Aims: Two medication change protocols were tested, both based on haemoglobin A1c (HbA1c), with one protocol also accounting for hypoglycaemic events. The aim was to compare the two protocols during intermittent energy restriction (5:2 diet).

Methods: Forty-two adults with type 2 diabetes (HbA1c ≥ 7% [53 mmol/mol], BMI of ≥27 kg/m) treated with sulphonylureas and/or insulin were recruited and randomised 1:1 to fixed or adjusted medication protocols. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.013DOI Listing
April 2019
2 Reads

The Direct Effect of Lobeglitazone, a New Thiazolidinedione, on Pancreatic Beta Cells: A Comparison with Other Thiazolidinediones.

Diabetes Res Clin Pract 2019 Apr 4. Epub 2019 Apr 4.

Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Inje University, Busan, Republic of Korea; Paik Institute for Clinical Research, Molecular Therapy Lab, Inje University, Busan, Republic of Korea. Electronic address:

Aims: The direct effects of thiazolidinediones (TZDs) on pancreatic beta cells have been controversial. The aim of this study was to find out whether a novel TZD, lobeglitazone, has beneficial effects on pancreatic beta cells and db/db mice compared to those of other TZDs.

Methods: INS-1 cells were incubated at a high-glucose concentration with various concentrations of troglitazone, rosiglitazone, pioglitazone, and lobeglitazone. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.006DOI Listing
April 2019
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Genetic polymorphisms associated with type 2 diabetes in the Arab world: a systematic review and meta-analysis.

Diabetes Res Clin Pract 2019 Apr 4. Epub 2019 Apr 4.

Department of Biomedical Sciences College of Health Sciences, Qatar University, Doha, Qatar. Electronic address:

Aims: T2DM reach epidemic levels in the Arab countries. In this study, we aimed to perform a systematic review and meta-analysis to underline the susceptibility genetic profile of Arab patients with T2DM that result from SNPs.

Methods: We searched four literature databases (PubMed, Scopus, Science Direct and Web of Science) through January 2019. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.037DOI Listing
April 2019
2 Reads

Response to Dirk Lund Christensen and Juan Lopez Taylor. ''Letter to the Editor: Misclassification of study population''.

Diabetes Res Clin Pract 2019 Apr 4. Epub 2019 Apr 4.

Departamento de Ciencias Biomédicas, Facultad de Medicina, Universidad Autónoma de Chihuahua, México.

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http://dx.doi.org/10.1016/j.diabres.2019.04.002DOI Listing

Long-term effectiveness of a type 2 diabetes comprehensive care program. The CAIPaDi model.

Diabetes Res Clin Pract 2019 Apr 4;151:128-137. Epub 2019 Apr 4.

Center of Comprehensive Care for the Patient with Diabetes, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Aims: To evaluate the effectiveness of a comprehensive care program to achieve and maintain goals in patients with type 2 diabetes.

Methods: The CAIPaDi program includes 9 interventions delivered in 7 h. It seeks to achieve metabolic goals, identify and resolve barriers that would make implementation difficult, and provide self-efficacy and empowerment to patients by identifying personal profiles to establish individualized strategies. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.009DOI Listing
April 2019
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Correlates of Low-adherence to Oral Hypoglycemic Medications among Hispanic/Latinos of Mexican Heritage with Type 2 Diabetes in the United States.

Diabetes Res Clin Pract 2019 Apr 4. Epub 2019 Apr 4.

Division of Health Promotion and Behavioral Science, Graduate School of Public Health, San Diego State University and Institute for Behavioral and Community Health, 9245 Sky Park Court, Suite 221 San Diego, CA 92123-4311, USA.

Aims: We examined psychosocial- and social/economic factors related to low medication adherence, and sex differences, among 279 adults of Mexican heritage with Type 2 Diabetes.

Methods: Self-report and health record data were used for cross-sectional analyses. Bivariate analyses tested the association of demographic, psychosocial (depression, anxiety, stress) and social/economic factors (insurance type, health literacy, social support) and two medication adherence measures (Morisky Medication Adherence Scale -8, a self-report survey, and Proportion of Days Covered). Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.007DOI Listing
April 2019
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Evidence of heterogeneity in statin-associated type 2 diabetes mellitus risk: A meta-analysis of randomized controlled trials and observational studies.

Diabetes Res Clin Pract 2019 Apr 4;151:96-105. Epub 2019 Apr 4.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

Aims: To conduct a meta-analysis of statin-associated type 2 diabetes mellitus (T2D) risk among randomized controlled trials (RCTs) and observational studies (OBSs), excluding studies conducted among secondary prevention populations.

Methods: Studies were identified by searching PubMed (1994-present) and EMBASE (1994-present). Articles had to meet the following criteria: (1) follow-up >one year; (2) >50% of participants free of clinically diagnosed ASCVD; (3) adult participants ≥30 years old; (4) reported statin-associated T2D effect estimates; and (5) quantified precision using 95% confidence interval. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183119
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http://dx.doi.org/10.1016/j.diabres.2019.04.005DOI Listing
April 2019
6 Reads

Empagliflozin versus dapagliflozin in patients with type 2 diabetes inadequately controlled with metformin, glimepiride and dipeptidyl peptide 4 inhibitors: A 52-week prospective observational study.

Diabetes Res Clin Pract 2019 Apr 4;151:65-73. Epub 2019 Apr 4.

Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Republic of Korea; Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea. Electronic address:

Aims: To directly compare the effectiveness and safety between two distinct sodium-glucose co-transporter 2 (SGLT2) inhibitors, empagliflozin and dapagliflozin, as part of a quadruple oral antidiabetic agents (OADs) in patients with inadequately controlled type 2 diabetes (T2D).

Methods: This study was an open-labeled, prospective, 52-week study conducted in T2D patients with glycated hemoglobin (HbA) ranging 7.5-12. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.04.008DOI Listing
April 2019
1 Read
2.538 Impact Factor

Renoprotective effect of camel milk in pediatric diabetic ketoacidosis: A focus on TLR-4/MAPK axis.

Diabetes Res Clin Pract 2019 Apr 2;151:88-95. Epub 2019 Apr 2.

Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Translational and Clinical Research Unit, Misr International University, Cairo, Egypt.

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http://dx.doi.org/10.1016/j.diabres.2019.04.001DOI Listing
April 2019
6 Reads

Establishing the incidence and timing of hypoglycemia at a residential diabetes camp.

Diabetes Res Clin Pract 2019 Apr 2;151:146-151. Epub 2019 Apr 2.

Department of Pediatrics, University of Minnesota, Minneapolis, MN 55454, United States; Division of Pediatric Endocrinology, University of Minnesota, Minneapolis, MN 55454, United States. Electronic address:

Aims: To establish the incidence and timing of hypoglycemia at a week-long residential diabetes camp for children. We hypothesized that hypoglycemia would occur more frequently during the first two days of camp and following evening all-camp games.

Methods: 225 children (mean age 12. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183140
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http://dx.doi.org/10.1016/j.diabres.2019.04.003DOI Listing
April 2019
4 Reads

Experiences of patients with diabetes observing the Ramadan fast: Diabetes Centre, Dammam Medical Complex, Dammam, Eastern Province.

Diabetes Res Clin Pract 2019 Apr 1. Epub 2019 Apr 1.

Internal Medicine Department, Dammam Medical Complex, Dammam, Saudi Arabia.

Aims: To describe the experience and behavior of diabetes patients toward Ramadan fasting. A Secondary purpose was to describe diabetes treatment and hypoglycemia during Ramadan.

Methods: A prospective, non-randomized study for 2 years. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.031DOI Listing
April 2019
3 Reads

Prevalence of gestational diabetes mellitus among women attending antenatal care at public health centers in Rwanda.

Diabetes Res Clin Pract 2019 Apr 1. Epub 2019 Apr 1.

Int'l Dispensary of Kigali.

Aim: This study aimed to determine the prevalence of gestational diabetes mellitus (GDM) among women attending public health centers in Rwanda using the World Health Organization (WHO) 2013 diagnostic criteria.

Methods: A cross-sectional analysis was performed on 281 pregnant women attending antenatal care at urban and rural public health centers. Diagnostic testing was performed between 24 and 32 gestation using a 75 g oral glucose tolerance test. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183169
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http://dx.doi.org/10.1016/j.diabres.2019.03.035DOI Listing
April 2019
2 Reads

Quantitative analysis of corneal nerve fibers in type 2 diabetics with and without diabetic peripheral neuropathy: Comparison of manual and automated assessments.

Diabetes Res Clin Pract 2019 Mar 30;151:33-38. Epub 2019 Mar 30.

Department of Endocrinology, Shanghai Jing'an District Central Hospital, Fudan University, Shanghai 200040, China. Electronic address:

Aims: To examine and compare fully-automated and manually measured corneal nerve fiber parameters in type 2 diabetes mellitus (T2DM) patients with and without diabetic peripheral neuropathy (DPN).

Methods: A total of 128 T2DM subjects and 24 healthy controls underwent neuropathy assessment and bilateral corneal confocal microscopy (CCM). Five representative nerve fiber images were selected for each participant and analyzed manually and with fully-automated software. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.039DOI Listing
March 2019
3 Reads
2.538 Impact Factor

Do free thyroxine levels influence the relationship between maternal serum ferritin and gestational diabetes mellitus in early pregnancy?

Diabetes Res Clin Pract 2019 Mar 30;151:114-119. Epub 2019 Mar 30.

Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, PR China. Electronic address:

Purpose: The objective of this study was to estimate the combined effect of serum ferritin (SF) concentration and free thyroxine (fT4) levels on the risk of gestational diabetes mellitus (GDM).

Methods: Women presented for antenatal care at a tertiary hospital in Shanghai, China were included in this study from December 2012 to March 2014. Women were divided into six groups according to the SF and fT4 level. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183127
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http://dx.doi.org/10.1016/j.diabres.2019.03.033DOI Listing
March 2019
6 Reads

Nutrient sensing pathway genes expression dysregulated in patients with T2DM and coronary artery disease.

Diabetes Res Clin Pract 2019 Mar 30;151:39-45. Epub 2019 Mar 30.

Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, P.O. Box 14115-154, Tehran, Iran. Electronic address:

Aims: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder and its prevalence is rapidly increasing worldwide. Patients with T2DM suffer from an increased risk of vascular complications. Of these, the development of coronary artery disease (CAD) causes the most mortality in patients with T2DM, however, its underlying molecular mechanisms are not fully understood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183167
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http://dx.doi.org/10.1016/j.diabres.2019.03.036DOI Listing
March 2019
2 Reads
2.538 Impact Factor

Assessment of glucose variability in subjects with prediabetes.

Diabetes Res Clin Pract 2019 Mar 30;151:56-64. Epub 2019 Mar 30.

Department of Diabetology, Clinical Center of Endocrinology and Gerontology, Medical University Sofia, Bulgaria.

The aim of the study was to assess glucose variability in subjects with prediabetes by means of CGM.

Material And Methods: 32 subjects with prediabetes - mean age 56.6 ± 9. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.038DOI Listing
March 2019
5 Reads

Temporal trend of newly diagnosed type 1 diabetes children and adolescents identified over a 35-year period in a Brazilian institution.

Diabetes Res Clin Pract 2019 Mar 30;151:82-87. Epub 2019 Mar 30.

Federal University of Minas Gerais, School of Medicine, Av. Prof. Alfredo Balena, 190, Belo Horizonte, Minas Gerais CEP:30130-100, Brazil.

Aims: To evaluate the temporal trend of newly diagnosed Type 1 Diabetes cases over a 35-year period in a reference Pediatric Endocrinology service in the city of Belo Horizonte, Brazil.

Methods: Subjects were all children and adolescents diagnosed with Type 1 Diabetes in the Federal University of Minas Gerais Hospital. Information collected included: gender, age and date of Type 1 diabetes diagnosis. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.040DOI Listing
March 2019
1 Read

Iron deficiency in long standing type 1 diabetes mellitus and its association with depression and impaired quality of life.

Diabetes Res Clin Pract 2019 Mar 30;151:74-81. Epub 2019 Mar 30.

Division of Endocrinology & Diabetes, Department of Internal Medicine 1, Goethe-University Hospital, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.

Aims: Iron deficiency (ID) is the most frequent malnutrition worldwide and often associated with reduced quality of life (QoL) and depression. We aimed to investigate the iron status in middle-aged type 1 diabetes in relation to depression and QoL.

Methods: 109 people with type 1 diabetes (54. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.034DOI Listing
March 2019
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Differential effects of gender and patient background diversity on the changes in metabolic and biophysical profiles in people with type-2 diabetes from different ethnicities who fast during Ramadan (H1439); a prospective study from Qatar.

Diabetes Res Clin Pract 2019 Mar 28. Epub 2019 Mar 28.

Department of Medicine & Qatar Metabolic Institute, Hamad Medical Corporation, Doha, Qatar.

Objective: The 'PROspective Study of dose adjustment of multiple anti-diabetic therapy for Type-2 diabetic patients FASTing the Month of Ramadan aimed to assess the biophysical and metabolic effects of fasting during Ramadan, including HbA1c, weight, blood pressure and lipid profile.

Study Design Methods: We performed a prospective study of people with Type-2 diabetes who were on ≥3 drugs for lowering glucose before and after Ramadan of H1438 (May-June 2017) in Hamad Medical Corporation, Qatar. We enrolled 228 participants, of whom 181 completed the study and were included in the analysis. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.032DOI Listing
March 2019
3 Reads

Use of graded Semmes Weinstein monofilament testing for ascertaining peripheral neuropathy in people with and without diabetes.

Diabetes Res Clin Pract 2019 Mar 25;151:1-10. Epub 2019 Mar 25.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive Kidney Diseases, National Institutes of Health, Phoenix, AZ, United States.

Aims: To assess peripheral neuropathy (PN) using graded Semmes Weinstein monofilaments (SWMs) and determine factors associated with PN among adult volunteers with and without diabetes.

Methods: Adult volunteers were assessed for distal sensory PN using three graded SWMs. Four PN levels were defined: 0 (no PN; felt all three filaments), 1 (subclinical PN; insensate to 1-g filament), 2 (insensate to 10-g), or 3 (insensate to 75-g). Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.029DOI Listing

High risk of metabolic syndrome after delivery in pregnancies complicated by gestational diabetes.

Diabetes Res Clin Pract 2019 Mar 21;150:219-226. Epub 2019 Mar 21.

Pennington Biomedical Research Center, Baton Rouge, LA, USA. Electronic address:

Aims: To investigate the risk of postpartum metabolic syndrome in women with GDM compared with those without GDM in a Chinese population.

Methods: Tianjin GDM observational study included 1263 women with a history of GDM and 705 women without GDM. Multivariate logistic regression was used to assess risks of postpartum metabolic syndrome between women with and without GDM. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.030DOI Listing
March 2019
2 Reads
2.538 Impact Factor

High HDL cholesterol: A risk factor for diabetic retinopathy? Findings from NO BLIND study.

Diabetes Res Clin Pract 2019 Mar 20;150:236-244. Epub 2019 Mar 20.

University of Campania "Luigi Vanvitelli", Department of Advanced Medical and Surgical Sciences, Piazza Luigi Miraglia 2, 80138 Naples, Italy. Electronic address:

Aims: To assess the correlation between diabetic retinopathy (DR) and potential risk factors, as well as the relationship between DR and the other complications of diabetes, in a real-life population of type 2 diabetes patients recruited in several centres in Italy.

Methods: The NO BLIND is a cross-sectional, multicentre, observational study, which involved nine public outpatient clinics in Italy. The patients were assessed for eligibility from November 2016 till November 2017. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.028DOI Listing
March 2019
2 Reads

A triadic perspective on control perceptions in youth with type 1 diabetes and their parents: Associations with treatment adherence and glycemic control.

Diabetes Res Clin Pract 2019 Mar 20;150:264-273. Epub 2019 Mar 20.

KU Leuven, Leuven, Belgium; UNIBS, University of the Free State, Bloemfontein, South Africa.

Aims: A family approach was applied to examine youth, maternal, and paternal control perceptions in relation to type 1 diabetes outcomes in adolescents and emerging adults. Mean levels of personal and treatment control were compared among patients and parents. Their associations with diabetes outcomes were examined as well. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.025DOI Listing

All-cause mortality in patients on sulfonylurea monotherapy.

Diabetes Res Clin Pract 2019 Mar 20. Epub 2019 Mar 20.

VA Puget Sound Healthcare System, Seattle University of Washington, School of Medicine, Department of Medicine, Seattle, WA, United States.

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http://dx.doi.org/10.1016/j.diabres.2019.03.021DOI Listing

Glycemic control and 10-year odds of all-cause fractures in elderly veterans with type 2 diabetes.

Diabetes Res Clin Pract 2019 Mar 20;151:46-55. Epub 2019 Mar 20.

Department of Veterans Affairs Eastern Kansas Health Care System, 2200 SW Gage Blvd, Topeka, KS 66622, United States. Electronic address:

Aims: To investigate the relationship of average level of glycemic control and fractures in elderly Veterans.

Methods: Retrospective cohort of Veterans (age ≥65) grouped as follows: no diabetes, HbA1c ≤7.0% [≤53 mmol/mol], HbA1c 7. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.027DOI Listing
March 2019
2 Reads

Bibliometric analysis of the literature on Ramadan fasting and diabetes in the past three decades (1989-2018).

Diabetes Res Clin Pract 2019 Mar 20. Epub 2019 Mar 20.

Division of Endocrinology, Institute of Medicine, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates; Department of Medicine, Dubai Medical College, Dubai, United Arab Emirates. Electronic address:

Objectives: To quantify the research contribution related to Ramadan fasting and diabetes.

Methods: We searched for the combination of "Ramadan" and Diabetes" in the title, abstract and keywords in the Scopus database between 1989 and 2018. Articles were analysed for standard bibliometric methodology and VOSviewer was used to construct bibliometric diagrams. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.023DOI Listing
March 2019
2.538 Impact Factor

Treatment of type 2 diabetes mellitus worldwide: Baseline patient characteristics in the global DISCOVER study.

Diabetes Res Clin Pract 2019 Mar 20;151:20-32. Epub 2019 Mar 20.

Peking University People's Hospital, Beijing, PR China. Electronic address:

Aims: To describe the characteristics and treatment of patients with type 2 diabetes mellitus initiating a second-line glucose-lowering therapy in the global DISCOVER study programme.

Methods: DISCOVER comprises two similar 3-year prospective observational studies (NCT02322762 and NCT02226822), involving 15,992 patients initiating a second-line glucose-lowering therapy in 38 countries across six regions (Africa, Americas, South-East Asia, Eastern Mediterranean, Europe and Western Pacific).

Results: Overall, 54. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.024DOI Listing
March 2019
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Lipoprotein-associated phospholipase A2 is a risk factor for diabetic kidney disease.

Diabetes Res Clin Pract 2019 Mar 20;150:194-201. Epub 2019 Mar 20.

Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Jiangsu, China. Electronic address:

Aims: This study aimed to determine the association between lipoprotein-associated phospholipase A2 (Lp-PLA2), a marker for inflammation in the vessel wall and independently associated with atherosclerosis, and the incidence of diabetic kidney disease (DKD) in patients with type 2 diabetes (T2D).

Methods: A total of 1452 patients were enrolled in this retrospective cross‑sectional study. We recruited patients with T2D who were tested for glycated hemoglobin, fasting and 2 h post-meal serum C-peptide, blood lipid profile, 24 h urine albumin excretion rate (UAER), blood creatine, blood albumin, uric acid, and Lp-PLA2. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.026DOI Listing
March 2019
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How group diabetes education in Argentina is changing lives.

Diabetes Res Clin Pract 2019 Mar;149:210-212

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http://dx.doi.org/10.1016/j.diabres.2019.03.006DOI Listing
March 2019
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Effect of Ramadan fasting on incidence of cerebrovascular stroke in Egyptian patients with Type 2 Diabetes Mellitus.

Diabetes Res Clin Pract 2019 Mar 19. Epub 2019 Mar 19.

Endocrinology and Diabetes Unit, Internal Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Diabetes is an independent risk factor for stroke disease. Fasting during Ramadan, Muslims must abstain from eating, drinking, taking oral medications, and smoking from the exact time of dawn until time of sunset; in this study we investigated if there is impact of Ramadan Fasting on incidence of Cerebrovascular stroke among Patients with Type 2 Diabetes Mellitus. This cross sectional study was conducted in medical ICU of Zagazig University Hospitals, in months of Sha'ban, Ramadan and Shawwal, in 1436; total numbers of 220 patients diagnosed as cerebrovascular stroke were enrolled in. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.012DOI Listing
March 2019
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The effect of intermittent compared with continuous energy restriction on glycaemic control in patients with type 2 diabetes: 24-month follow-up of a randomised noninferiority trial.

Diabetes Res Clin Pract 2019 Mar 19;151:11-19. Epub 2019 Mar 19.

School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia; Alliance for Research in Exercise, Nutrition and Activity (ARENA), Australia.

Aims: We investigated the effects of intermittent compared to continuous energy restriction on glycaemic control in patients with type 2 diabetes mellitus.

Methods: Adults (N = 137) with type 2 diabetes (mean [SD] HbA1c level, 7.3% (56 mmol/mol) [1. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.022DOI Listing

Association of first-trimester HbA1c levels with adverse pregnancy outcomes in different ethnic groups.

Diabetes Res Clin Pract 2019 Mar 15;150:202-210. Epub 2019 Mar 15.

Department of Endocrinology and Nutrition, Hospital del Mar, E-08003 Barcelona, Spain; Department of Medicine, Universitat Autònoma de Barcelona, E-08003 Barcelona, Spain. Electronic address:

Aim: To determine, in a multi-ethnic cohort, the association of first-trimester HbA1c levels with the development of pregnancy complications.

Methods: A prospective study between April 2013-October 2016. Participants were stratified in five ethnic groups. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183149
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http://dx.doi.org/10.1016/j.diabres.2019.03.017DOI Listing
March 2019
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The use of Free Style Libre Continues Glucose Monitoring (FSL-CGM) to monitor the impact of Ramadan fasting on glycemic changes and kidney function in high-risk patients with diabetes and chronic kidney disease stage 3 under optimal diabetes care.

Diabetes Res Clin Pract 2019 Mar 14. Epub 2019 Mar 14.

Endocrine Department, Dubai Hospital, Dubai Health Authority, United Arab Emirates.

Aim: To understand the risk of hypoglycaemia during Ramadan fasting by use of CGM, as well as to observe the Glycemic control and renal functions in patients with diabetes and chronic kidney disease stage 3 (CKD-3).

Method: A prospective interventional study conducted in the Dubai Hospital, a tertiary care centre in the United Arab Emirates, during the month of Ramadan 1437 AH (Hijri), which corresponded to June 6th till July 5th, 2016. 25 patients with type 2 diabetes and stage 3 chronic kidney disease (CKD stage 3) were included in the study, who intended to fast during Ramadan. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.015DOI Listing
March 2019
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2.538 Impact Factor

Assessing the perceived impact of diabetes on quality of life: Psychometric validation of the DAWN2 Impact of Diabetes Profile in the second Diabetes MILES - Australia (MILES-2) survey.

Diabetes Res Clin Pract 2019 Mar 14;150:253-263. Epub 2019 Mar 14.

School of Psychology, Deakin University, Geelong, VIC, Australia; The Australian Centre for Behavioural Research in Diabetes, Diabetes Victoria, Melbourne, VIC, Australia; Department of Psychology, University of Southern Denmark, Odense M, Denmark; AHP Research, Hornchurch, Essex, UK. Electronic address:

Aims: To investigate the validity and reliability of the 6-item DAWN2 Impact of Diabetes Profile (DIDP), and the modified 7-item DIDP, which includes assessment of dietary freedom.

Methods: The online, cross-sectional, Australian MILES-2 survey included the DIDP and other validated measures, to examine convergent, discriminant and known-groups validity. The DIDP was completed by 2207 adults with diabetes (Type 1: n = 1012; Type 2 insulin: n = 504; non-insulin: n = 691). Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.020DOI Listing

Correlation between diabetes mellitus and periodontitis in Taiwan: A nationwide cohort study.

Diabetes Res Clin Pract 2019 Mar 14;150:245-252. Epub 2019 Mar 14.

Department of Health Services Administration, China Medical University, Taichung, Taiwan. Electronic address:

Aims: The mechanism underlying the association of diabetes mellitus (DM) and periodontitis is not clear. This study aimed to investigate the correlation between DM and periodontitis.

Methods: This study was a retrospective cohort study, which conducted based on the Taiwan National Health Insurance Research Database. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.019DOI Listing
March 2019
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Promising anti-diabetic effect of dextran sulfate sodium: Is it its clinical come back?

Diabetes Res Clin Pract 2019 Mar 14. Epub 2019 Mar 14.

Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine and Medical Center, American University of Beirut, Beirut, Lebanon. Electronic address:

Clinical studies showed that dextran sulfate sodium (DSS) alleviates stroke, diabetic retinopathy and hypercholesterolemia, yet its mechanism of action was unrevealed. This study show that DSS reduces hyperglycemia, plasma insulin and enhances glucose utilization by attenuating ROS production, suggesting a novel therapeutic use of DSS in diabetes and its complication. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.016DOI Listing
March 2019
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Misclassification of study population.

Diabetes Res Clin Pract 2019 Mar 14. Epub 2019 Mar 14.

University of Guadalajara, Guadalajara, Mexico.

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http://dx.doi.org/10.1016/j.diabres.2019.03.011DOI Listing

Diabetes distress among healthcare providers: A qualitative study.

Diabetes Res Clin Pract 2019 Mar 14;150:211-218. Epub 2019 Mar 14.

Indiana University School of Medicine, USA. Electronic address:

Aims: Diabetes-related distress stemming from the burden of managing diabetes has been measured in multiple patient populations; however, the medical management of diabetes also presents unique challenges for health care providers. The purpose of this study was to conduct a qualitative evaluation of the experiences of healthcare providers in caring for people with diabetes (PWD).

Methods: Interviews and focus groups were conducted in a sample of 22 healthcare providers. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.018DOI Listing
March 2019
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C-peptide predicts all-cause and cardiovascular death in a cohort of individuals with newly diagnosed type 2 diabetes. The Skaraborg diabetes register.

Diabetes Res Clin Pract 2019 Mar 13;150:174-183. Epub 2019 Mar 13.

Department of Public Health and Community Medicine/Primary Health Care, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden; R&D Center Skaraborg Primary Care, Skövde, Sweden.

Aims: To study the association between baseline level of C-peptide and all-cause death, cardiovascular death and cardiovascular complications among persons with newly diagnosed type 2 diabetes.

Methods: The Skaraborg Diabetes Register contains data on baseline C-peptide concentrations among 398 persons <65 years with newly diagnosed type 2 diabetes 1996-1998. National registries were used to determine all-cause death, cardiovascular death and incidence of myocardial infarction and ischemic stroke until 31 December 2014. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183160
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http://dx.doi.org/10.1016/j.diabres.2019.03.014DOI Listing
March 2019
6 Reads