650,414 results match your criteria Diabetes research and clinical practice[Journal]


Apolipoprotein CIII and diabetes. Is there a link?

Diabetes Metab Res Rev 2018 Dec 17:e3118. Epub 2018 Dec 17.

Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.

Apolipoprotein CIII (ApoCIII), a small protein that resides on the surface of lipoprotein particles, is a key regulator of triglyceride metabolism. The inhibition of lipoprotein lipase (LPL), the increased assembly and secretion of very low-density lipoproteins (VLDL) and the decreased reuptake of triglyceride-rich lipoproteins (TRLs) by the liver are mechanisms associating elevated serum ApoCIII levels and hypertriglyceridemia. ApoCIII concentration is high in individuals with diabetes mellitus indicating a possible positive correlation with impairment of glucose metabolism. Read More

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December 2018

Adherence to Therapeutic Footwear in Type 2 Diabetes in Malta.

Exp Clin Endocrinol Diabetes 2018 Dec 17. Epub 2018 Dec 17.

Faculty of Health Sciences, University of Malta.

Background: The literature reports that people living with diabetes do not adhere to their prescribed therapeutic footwear as instructed. The reason for this is still uncertian although certain footwear characteristics seem to reasons reported leading to reduced level of adherence.

Objectives: To explore the reasons for current adherence or otherwise to prescribed stock footwear amongst patients living with type-2 diabetes. Read More

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December 2018

Peripheral Insulin Extraction in Non-Diabetic Subjects and Type 2 Diabetes Mellitus Patients.

Exp Clin Endocrinol Diabetes 2018 Dec 17. Epub 2018 Dec 17.

Department of Internal Medicine, Spaarne Gasthuis, Haarlem, The Netherlands.

Background: Insulin has to be transported across the capillary endothelium to stimulate muscle glucose uptake. We investigated insulin uptake from the peripheral circulation in non-diabetic (ND) individuals and in type 2 diabetes (T2D) patients.

Methods: Single-center cross-sectional study involving 40 ND (age 65±11 years) and 30 T2D patients (age 67±8 years). Read More

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December 2018

Assessment of Exercise Capacity in Children with Type 1 Diabetes in the Cooper Running Test.

Int J Sports Med 2018 Dec 17. Epub 2018 Dec 17.

Department of Pediatrics, Diabetology, Endocrinology and Nephrology, Medical University of Lodz, Lodz, Poland.

Regular physical activity increases lifespan for those with type 1 diabetes. However, disease-related barriers may deter children from exercise and affect their fitness. This study examined the safety of the Cooper test concerning diabetes-related acute complications in children with type 1 diabetes and their fitness. Read More

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December 2018

Cubilin Single Nucleotide Polymorphism Variants are Associated with Macroangiopathy While a Matrix Metalloproteinase-9 Single Nucleotide Polymorphism Flip-Flop may Indicate Susceptibility of Diabetic Nephropathy in Type-2 Diabetic Patients.

Nephron 2018 Dec 17:1-10. Epub 2018 Dec 17.

Clinic of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke University, Magdeburg, Germany.

Aim: Aim of this study was to investigate the association of genetic variants of functional polymorphisms of matrix metalloproteinase and Cubilin (CUBN) with diabetic nephropathy (DN), end-stage renal disease (ESRD), and risk of cardiovascular disease (CVD) in Caucasian type 2 diabetes (T2D) patients.

Methods: 472 T2D-patients were genotyped for 3 single-nucleotide polymorphisms (SNPs; MMP-2 [rs2285053], MMP-9 [rs17576] and CUBN [rs1801239]). Genotyping was carried out by allelic discrimination using TaqMan SNP-genotyping-assay. Read More

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December 2018

Short-Term Steroid Regimen for Adult Steroid-Sensitive Minimal Change Disease.

Am J Nephrol 2018 Dec 17;49(1):54-63. Epub 2018 Dec 17.

Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya,

Background: In pediatric patients with steroid-sensitive nephrotic syndrome, recent trials have revealed that a 2-month, short-term steroid regimen is not inferior to an extended steroid course. However, the optimal duration of initial steroid therapy for adult steroid-sensitive minimal change disease (MCD) remains unclear.

Objectives: The aim of present study was to evaluate the effectiveness of a 2-month, short-term steroid regimen in the treatment of adult steroid-sensitive MCD patients. Read More

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December 2018

Dipeptidyl peptidase-4 inhibition protects the liver of insulin-resistant female rats against triglyceride accumulation by suppressing uric acid.

Biomed Pharmacother 2018 Dec 14;110:869-877. Epub 2018 Dec 14.

HOPE Cardiometabolic Research Team, Department of Physiology, College of Health Sciences, University of Ilorin, Nigeria. Electronic address:

Dipeptidyl peptidase-4 (DPP-4) inhibition has been shown to exert beneficial effects against insulin resistance (IR) and type 2 diabetes. Combined oral contraceptive (COC) treatment is associated with impaired glucose and lipid metabolism but the mechanisms are elusive. We therefore, hypothesized that DPP-4 inhibition ameliorates COC-induced glucose dysregulation and hepatic triglyceride (TG) accumulation through adenosine deaminase (ADA) /xanthine oxidase (XO) /uric acid-dependent pathway. Read More

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December 2018

Identification of novel PPARα/γ dual agonists by pharmacophore screening, docking analysis, ADMET prediction and molecular dynamics simulations.

Comput Biol Chem 2018 Nov 27;78:178-189. Epub 2018 Nov 27.

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, China. Electronic address:

PPARα and PPARγ play an important role in regulating glucose and lipid metabolism. The single and selective PPARα or PPARγ agonists have caused several side effects such as edema, weight gain and cardiac failure. In the recent years, the dual PPARs agonist development has become a hot topic in the antidiabetic medicinal chemistry field. Read More

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November 2018

Validation of Diagnostic and Performance Characteristics of the Wireless Motility Capsule in Patients With Suspected Gastroparesis.

Clin Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Division of Gastroenterology, Massachusetts General Hospital, Boston, MA. Electronic address:

Background & Aims: It is a challenge to make a diagnosis of gastroparesis. There is good agreement in results from wireless motility capsule (WMC) analysis and gastric emptying scintigraphy (GES), but the diagnostic yield of WMC is unclear and the accuracy of this method has not been validated. We compared the performance characteristics of WMC vs GES in assessing gastric emptying in patients with suspected gastroparesis. Read More

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December 2018

Association between ambient particulate matter air pollution and ST-elevation myocardial infarction: A case-crossover study in a Chinese city.

Chemosphere 2018 Dec 12;219:724-729. Epub 2018 Dec 12.

Department of Cardiology, Yancheng Hospital Affiliated to Xuzhou Medical University and the First Hospital of Yancheng, Yancheng, 224006, China. Electronic address:

Background: Abundant epidemiological studies have revealed that short-term exposure to ambient air pollution increased the incidence of ischemic heart diseases. However, few investigations have explored the association between air pollution and ST-elevation myocardial infarction (STEMI), one major subtype of such events.

Methods: We conducted a time-stratified case-crossover study in two major hospitals of Yancheng, a city in East China, from January 2015 to February 2018. Read More

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December 2018

A mouse model for intellectual disability caused by mutations in the X-linked 2'‑O‑methyltransferase Ftsj1 gene.

Biochim Biophys Acta Mol Basis Dis 2018 Dec 14. Epub 2018 Dec 14.

Department of Functional Genomics, Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Felix-Hausdorff-Strasse 8, 17489 Greifswald, Germany.

Mutations in the X chromosomal tRNA 2'‑O‑methyltransferase FTSJ1 cause intellectual disability (ID). Although the gene is ubiquitously expressed affected individuals present no consistent clinical features beyond ID. In order to study the pathological mechanism involved in the aetiology of FTSJ1 deficiency-related cognitive impairment, we generated and characterized an Ftsj1 deficient mouse line based on the gene trapped stem cell line RRD143. Read More

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December 2018

Vascular burden and APOE ε4 are associated with white matter microstructural decline in cognitively normal older adults.

Neuroimage 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD 21224, USA.

White matter microstructure can be measured with diffusion tensor imaging (DTI). While increasing age is a predictor of white matter (WM) microstructure changes, roles of other possible modifiers, such as cardiovascular risk factors, APOE ε4 allele status and biological sex have not been clarified. We investigated 665 cognitively normal participants from the Baltimore Longitudinal Study of Aging (age 50-95, 56. Read More

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December 2018

Body composition and bone mineral density in childhood.

Bone 2018 Dec 14. Epub 2018 Dec 14.

Pediatric Endocrinology and Diabetes, Maine Medical Center, Portland, ME, USA; Center for Outcomes Research and Evaluation, Maine Medical Center Research Institute, Portland, ME, USA.

Background: Body mass compartments may have different directions of influence on bone accrual. Studies of children are limited by relatively small sample sizes and typically make strong assumptions of linear regression.

Objective: To evaluate associations of overall body mass, components of overall body mass (fat-free and total fat), and components of total fat mass (truncal and non-truncal fat), measured via dual-energy X-ray absorptiometry (DXA) and anthropometry, with total body less head areal bone mineral density (aBMD) Z-score in mid-childhood. Read More

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December 2018

A tale of two steroids: the importance of the androgens DHEA and DHEAS for early neurodevelopment.

J Steroid Biochem Mol Biol 2018 Dec 14. Epub 2018 Dec 14.

School of Health & Biomedical Sciences, RMIT University - Bundoora Campus, Melbourne, 3083, Australia. Electronic address:

DHEA and DHEAS are neuroactive neurosteroids that interact with several major receptor system in the brain, including sigma (σ), glutamate, and GABA-A receptors. It has been recognized as early as 1952, that the loss of DHEA/DHEAS in adult life is associated with neuropsychiatric disorders (eg schizophrenia, depression). However, the mechanistic role for DHEA/DHEAS in any of these domains remains speculative, not the least because the presence of these androgens in the adrenal gland and brain is largely confined to humans and only some non-human primates. Read More

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December 2018

Recombinant growth hormone therapy for cystic fibrosis in children and young adults.

Cochrane Database Syst Rev 2018 Dec 17;12:CD008901. Epub 2018 Dec 17.

Division of Molecular Genetics, Department of Pediatrics, Columbia University Medical Center, 630 West 168th St., New York, NY, USA, 10032.

Background: Cystic fibrosis (CF) is an inherited condition causing disease most noticeably in the lungs, digestive tract and pancreas. People with CF often have malnutrition and growth delay. Adequate nutritional supplementation does not improve growth optimally and hence an anabolic agent, recombinant human growth hormone (rhGH), has been proposed as a potential intervention. Read More

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December 2018

Guidelines Versus Guidelines.

Ann Intern Med 2018 Dec;169(12):896-897

American Diabetes Association, Arlington, Virginia (W.T.C.).

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December 2018

Experiences of mobile health in promoting physical activity: A qualitative systematic review and meta-ethnography.

PLoS One 2018 17;13(12):e0208759. Epub 2018 Dec 17.

School of Allied Health, University of Limerick, Castletroy, Limerick, Ireland.

Objective: Despite evidence supporting physical activity in primary and secondary prevention, many individuals do not meet recommended levels. Mobile health is a field with a growing evidence base and is proposed as a convenient method for delivering health interventions. Despite qualitative exploration of stakeholder perspectives, there is a lack of synthesis to inform evidence-based design. Read More

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December 2018

Reduced body weight at weaning followed by increased post-weaning growth rate interacts with part-per-trillion fetal serum concentrations of bisphenol A (BPA) to impair glucose tolerance in male mice.

PLoS One 2018 17;13(12):e0208846. Epub 2018 Dec 17.

Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, United States of America.

There is evidence from longitudinal studies that being light at birth and weaning is associated with subsequent rapid weight gain in infants. This is referred to as "centile crossing", which can lead to increased risk of lifetime obesity, glucose dysregulation and type 2 diabetes. Here, pregnant CD-1 mice were hemi-ovariectomized so that the entire litter was contained in one uterine horn to increase variability in fetal growth rate. Read More

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December 2018

Role of CTRP3, CTRP9 and MCP-1 for the evaluation of T2DM associated coronary artery disease in Egyptian postmenopausal females.

PLoS One 2018 17;13(12):e0208038. Epub 2018 Dec 17.

Biochemistry Department, Faculty of Pharmacy, Ain Shams University, African Union Authority St. Abassia, Cairo, Egypt.

C1q complement/tumor necrosis factor (TNF)-related protein (CTRP) family comprises of 15 proteins that posses important implications in energy homeostasis, infection and inflammation. However, their roles in diabetes mellitus (DM) and its vascular complications have not been completely assessed. This works aims to study the association of two CTRPs; 3 and 9, with pro-inflammatory cytokine monocyte chemoattractant protein-1 (MCP-1), and biochemical parameters of type 2 diabetes (T2D), dyslipidemia and coronary artery disease (CAD). Read More

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December 2018

Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients.

PLoS One 2018 17;13(12):e0208998. Epub 2018 Dec 17.

Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca Gothenburg, Mölndal, Sweden.

Aims/hypothesis: GPR44 (DP2, PTGDR2, CRTh2) is the receptor for the pro-inflammatory mediator prostaglandin D2 (PGD2) and it is enriched in human islets. In rodent islets, PGD2 is produced in response to glucose, suggesting that the PGD2-GPR44/DP2 axis may play a role in human islet function during hyperglycemia. Consequently, the aim of this work was to elucidate the insulinotropic role of GPR44 antagonism in vitro in human beta-cells and in type 2 diabetes (T2DM) patients. Read More

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December 2018

Association and biomarker potential of elevated serum adiponectin with nephropathy among type 1 and type 2 diabetics: A meta-analysis.

PLoS One 2018 17;13(12):e0208905. Epub 2018 Dec 17.

Graduate School, University of Santo Tomas, Manila City, Philippines.

Background: Managing nephropathy associated with diabetes mellitus warrant investigation of relevant biomarkers in predicting this condition. Adiponectin (ADP) may hold promise as a biomarker for diabetic nephropathy (DN). In this study, we examine associations of ADP with DN by meta-analyzing relevant literature. Read More

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December 2018

Photobiomodulation therapy in neuroischaemic diabetic foot ulcers: a novel method of limb salvage.

J Wound Care 2018 Dec;27(12):837-842

Assistant Professor-Senior Scale, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Objective:: Low-level laser therapy (also known as photobiomodulation therapy, PBMT) promotes accelerated healing of diabetic foot ulcers (DFUs), thereby preventing the risk of future complications and amputation. The aim of this study was to determine the effect of PBMT, with structured, graded mobilisation and foot care, on DFU healing dynamics.

Method:: Patients diagnosed with type 2 diabetes, diabetic peripheral neuropathy and presenting with a chronic neuroischaemic DFU, were treated with PBMT using scanning and non-contact probe methods. Read More

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December 2018

Cryopreserved amniotic membrane in the treatment of diabetic foot ulcers: a case series.

J Wound Care 2018 Dec;27(12):806-815

Department of General Surgery, Hospital Clínico Universitario Virgen de la Arrixaca. Biomedical Research Institute of Murcia (Instituto Murciano de Investigación Biosanitaria, IMIB-Arrixaca). El Palmar, Spain.

Objective:: The amniotic membrane (AM) is a tissue with low immunogenity and high therapeutic potential due to its anti-inflammatory, anti-fibrotic and antimicrobial effects. This paper describes the use of cryopreserved amniotic membrane allografts to treat diabetic foot ulcers (DFUs) in patients with diabetes.

Method:: In this case series, AM was processed to obtain a final medicinal product: cryopreserved amniotic membrane. Read More

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December 2018

Investigation of galectin-3 levels in diabetic foot ulcers.

J Wound Care 2018 Dec;27(12):843-848

Professor, Harran University, School of Medicine, Department of Endocrinology, Sanliurfa, Turkey.

Objective:: It has been shown that galectin-3 (Gal-3) promotes angiogenesis and new vessel formation. Serum Gal-3 is a risk factor for vascular complications in type 2 diabetes. The aim of this study is to compare Gal-3 levels with a range of biochemical parameters. Read More

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December 2018

Shared illness appraisal and self-efficacy among adults with type 1 diabetes.

J Health Psychol 2018 Dec 17:1359105318817895. Epub 2018 Dec 17.

2 The University of Utah, USA.

We examined the interaction between shared illness appraisal and self-efficacy among couples in which one partner was diagnosed with type 1 diabetes ( n = 199). We hypothesized that the relation between self-efficacy and health would be weakened under conditions of shared rather than individual appraisal. Multiple regression analyses demonstrated that partner shared illness appraisal interacted with the self-efficacy of the person with type 1 diabetes to predict overall psychological distress and daily diabetes stressors in the predicted direction. Read More

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December 2018

Fibrosis-4 index at diagnosis can predict all-cause mortality in patients with rheumatoid arthritis: a retrospective monocentric study.

Mod Rheumatol 2018 Dec 17:1-16. Epub 2018 Dec 17.

c Division of Rheumatology, Department of Internal Medicine , Yonsei University College of Medicine , Seoul , Republic of Korea.

Objectives Comorbidities and conventional risk factors influence the prognosis of patients with rheumatoid arthritis (RA). We investigated whether liver fibrosis burden is associated with all-cause mortality in patients with RA. Methods A total of 2812 patients with RA were retrospectively selected and reviewed. Read More

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December 2018

Prospective associations between cardiac stress, glucose dysregulation and executive cognitive function in Black men: The Sympathetic activity and Ambulatory Blood Pressure in Africans study.

Diab Vasc Dis Res 2018 Dec 17:1479164118816221. Epub 2018 Dec 17.

1 Hypertension in Africa Research Team (HART) and School for Physiology, Nutrition and Consumer Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.

Objective:: Glucose dysregulation is an independent risk factor for cardiovascular and neurodegenerative disease development through synaptic dysfunction resulting in cognitive decline. The aim of this study was to study the interplay between impaired glycaemic metabolism (hyperglycaemia and insulin resistance), cardiac stress (cardiac troponin T and N-terminal brain natriuretic peptide) and executive cognitive function prospectively, in a bi-ethnic sex cohort.

Methods:: Black and White teachers (N = 338, aged 20-63 years) from the Sympathetic activity and Ambulatory Blood Pressure in Africans study were monitored over a 3-year period. Read More

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December 2018

Short-acting insulin analogues versus regular human insulin for adult, non-pregnant persons with type 2 diabetes mellitus.

Cochrane Database Syst Rev 2018 Dec 17;12:CD013228. Epub 2018 Dec 17.

Institute of General Practice, Goethe University, Theodor-Stern-Kai 7, Frankfurt am Main, Hesse, Germany, 60590.

Background: The use of short-acting insulin analogues (insulin lispro, insulin aspart, insulin glulisine) for adult, non-pregnant people with type 2 diabetes is still controversial, as reflected in many scientific debates.

Objectives: To assess the effects of short-acting insulin analogues compared to regular human insulin in adult, non-pregnant people with type 2 diabetes mellitus.

Search Methods: For this update we searched CENTRAL, MEDLINE, Embase, the WHO ICTRP Search Portal, and ClinicalTrials. Read More

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December 2018

The association of the rs670 variant of APOA1 gene with insulin resistance and lipid profile in morbid obese patients after a biliopancreatic diversion surgery.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8472-8479

Department of Endocrinology and Nutrition, Endocrinology and Nutrition Research Center, School of Medicine, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.

Objective: A common G-to-A transition (rs670) of the Apoprotein subtype 1 APOA1 gene has been evaluated. The presence of the A allele has been related with increased activity. We investigated the role of this genetic variant (rs670) on lipoprotein levels and anthropometric parameters after biliopancreatic diversion (BPD) surgery in morbid obese patients. Read More

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December 2018

Associations Between Migraine and Type 2 Diabetes in Women: Findings From the E3N Cohort Study.

JAMA Neurol 2018 Dec 17. Epub 2018 Dec 17.

Center for Research in Epidemiology and Population Health, UMR 1018, Institut National de la Santé et de la Recherche Médicale (INSERM) U1018, Paris-South Paris Saclay University, Gustave Roussy Institute, Villejuif, France.

Importance: Little is known about the associations between migraine and type 2 diabetes and the temporality of the association between these 2 diseases.

Objective: To evaluate the association between migraine and type 2 diabetes incidence as well as the evolution of the prevalence of active migraine before and after type 2 diabetes diagnosis.

Design, Setting, And Participants: We used data from the E3N cohort study, a French prospective population-based study initiated in 1990 on a cohort of women born between 1925 and 1950. Read More

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December 2018

Elevated arterial shear rate increases indexes of endothelial cell autophagy and nitric oxide synthase activation in humans.

Am J Physiol Heart Circ Physiol 2019 Jan 9;316(1):H106-H112. Epub 2018 Nov 9.

Department of Nutrition and Integrative Physiology, University of Utah , Salt Lake City, Utah.

Continuous laminar shear stress increases the process of autophagy, activates endothelial nitric oxide (NO) synthase phosphorylation at serine 1177 (p-eNOS), and generates NO in bovine and human arterial endothelial cells (ECs) compared with static controls. However, the translational relevance of these findings has not been explored. In the current study, primary ECs were collected from the radial artery of 7 men using sterile J-wires before (Pre) and after (Post) 60 min of rhythmic handgrip exercise (HG) performed with the same arm. Read More

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January 2019

Real-world outcomes post-transition to once-every-three-month paliperidone palmitate in patients with schizophrenia within US commercial plans.

Curr Med Res Opin 2018 Dec 17. Epub 2018 Dec 17.

b Janssen Scientific Affairs, LLC , Titusville , NJ , 08560 , USA.

Objectives: To compare comorbidity-related outcomes, adherence to APs, healthcare resource utilization (HRU), and costs pre- and post-transition to once-every-three-month paliperidone palmitate (PP3M) in commercially-insured patients with schizophrenia.

Methods: Adults with ≥1 claim for PP3M, ≥2 schizophrenia diagnoses, and adequate treatment with once-monthly paliperidone palmitate (PP1M; i.e. Read More

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December 2018

Comparing anxiety and depression to obesity and smoking as predictors of major medical illnesses and somatic symptoms.

Health Psychol 2018 Dec 17. Epub 2018 Dec 17.

San Francisco VA Medical Center.

Objective: Anxiety and depression predict poor physical health longitudinally, but are neglected in primary care settings compared to other risk factors such as obesity and smoking. Further, anxiety has been less commonly studied than depression, and whether anxiety has unique predictive effects for physical health is unknown. We compared anxiety and depression to obesity and smoking as predictors of physical health indices and examined unique predictive effects of anxiety and depression. Read More

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December 2018

For Debate: Paediatric T1DM: DKA is Still a Problem.

Pediatr Endocrinol Rev 2018 Dec;16(2):233-239

Hospital Universitario de Cruces, CIBERDEM, CIBERER, BIOCRUCES, Plaza Cruces s/n, 48903 Bizkaia, Spain, E-mail:

Although the treatment of pediatric patients with T1DM has improved ketoacidosis (DKA) remains a frequent problem.

Objective: To estimate temporal changes in the prevalence of DKA at diagnosis of T1DM and to explore the factors associated with its occurrence.

Methods: Paediatric patients diagnosed at Cruces University Hospital (Spain) since 1997 were included. Read More

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December 2018

Systematic review of ganciclovir pharmacodynamics during the prevention of cytomegalovirus infection in adult solid organ transplant recipients.

Rev Med Virol 2018 Dec 17:e2023. Epub 2018 Dec 17.

Serology and Virology Division, NSW Health Pathology, Prince of Wales Hospital, Sydney, New South Wales, Australia.

Human cytomegalovirus (CMV) represents the most common infection among recipients of solid organ transplants (SOTs). Previous meta-analysis showed 0.8% of SOT recipients developed CMV disease whilst receiving valganciclovir (ValGCV) prophylaxis. Read More

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December 2018

Visceral Obesity Relates to Deep White Matter Hyperintensities via Inflammation.

Ann Neurol 2018 Dec 17. Epub 2018 Dec 17.

Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Objective: White matter hyperintensities (WMH) are linked to vascular risk factors and increase the risk of cognitive decline, dementia and stroke. We here aimed to determine if obesity contributes to regional WMH using a whole-brain approach in a well-characterized population-based cohort.

Methods: Waist-to-hip ratio (WHR), body mass index (BMI), systolic/diastolic blood pressure, hypertension, diabetes and smoking status, blood glucose and inflammatory markers as well as distribution of WMH were assessed in 1825 participants of the LIFE-adult study (age 20-82 years; BMI 18. Read More

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December 2018

Multi-Target Drugs Against Metabolic Disorders.

Endocr Metab Immune Disord Drug Targets 2018 Dec 17. Epub 2018 Dec 17.

Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba, João Pessoa - PB. Brazil.

In silico studies are increasingly being applied by researchers due to reductions in time and costs for new prototype synthesis; obtaining substances that present better therapeutic profiles. In the present work, in addition to discussing multi-target drug discovery and the contributions of in silico studies to rational bioactive planning against metabolic disorders such as diabetes and obesity, we review various in silico study contributions to the fight against human metabolic pathologies. Read More

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December 2018

Inhibition of α-amylase activity by Zn2+: insights from spectroscopy and molecular dynamics simulations.

Med Chem 2018 Dec 16. Epub 2018 Dec 16.

College of Life Science and Technology, Guangxi University, Nanning, Guangxi, 530004 . China.

Background: Inhibition of α-amylase activity is an important strategy in the treatment of diabetes mellitus. An important treatment for diabetes mellitus is to reduce the digestion of carbohydrates and blood glucose concentrations. Inhibiting the activity of carbohydrate-degrading enzymes such as α-amylase and glucosidase significantly decreases the blood glucose level. Read More

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December 2018

Drug Development Strategy for Type 2 Diabetes: Targeting Positive Energy Balances.

Curr Drug Targets 2018 Dec 16. Epub 2018 Dec 16.

Division of Cardiovascular and Renal Products, Office of New Drugs I, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993. United States.

Newer classes of medications have been proven useful in glycemic control in type 2 diabetes (T2D), but many do not appear capable to slow down the progressive loss of ß-cell function, or to improve population-level glycemic control. Positive energy balance, e.g. Read More

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December 2018

Management of Children With Diabetes in the School Setting.

Authors:

Diabetes Educ 2018 Dec 17:145721718820943. Epub 2018 Dec 17.

Diabetes educators are well positioned to help optimize care of the student with diabetes within the school setting. Read More

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December 2018
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The Role of the Diabetes Educator in Diabetes Formulary and Medical Device Decisions.

Authors:

Diabetes Educ 2018 Dec 17:145721718820942. Epub 2018 Dec 17.

It is the position of the American Association of Diabetes Educators that diabetes educators should be included as expert consultants for formulary decisions regarding diabetes medications and medical devices. Read More

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December 2018

Role of the Diabetes Educator in Inpatient Diabetes Management.

Authors:

Diabetes Educ 2018 Dec 17:145721718820944. Epub 2018 Dec 17.

It is the position of American Association of Diabetes Educators (AADE) that all inpatient interdisciplinary teams include a diabetes educator to lead or support improvement efforts that affect patients hospitalized with diabetes or hyperglycemia. This not only encompasses patient and family education but education of interdisciplinary team members and achievement of diabetes-related organizational quality metrics and performance outcomes. Read More

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December 2018
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Intravitreal fluocinolone acetonide implant (ILUVIEN®) for diabetic macular oedema: a literature review.

J Int Med Res 2018 Dec 16:300060518816884. Epub 2018 Dec 16.

2 Eye Treatment Centre, Whipps Cross University Hospital, Barts Health NHS Trust, London, UK.

Diabetic macular oedema (DMO) is a common complication of diabetic retinopathy and may lead to severe visual loss. In this review, we describe the pathophysiology of DMO and review current therapeutic options such as macular laser photocoagulation, anti-vascular endothelial growth factor agents, and steroid implants with a focus on the new fluocinolone acetonide implant, ILUVIEN®. The results of the Fluocinolone Acetonide in Diabetic Macular Edema (FAME) studies are also presented together with the results of real-world studies to support the clinical use of ILUVIEN® in achieving efficient resolution of DMO and improving vision and macular anatomy in this challenging group of patients. Read More

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December 2018

Cardiometabolic risks in PCOS: a review of the current state of knowledge.

Expert Rev Endocrinol Metab 2018 Dec 4:1-11. Epub 2018 Dec 4.

a Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine , Monash University , Melbourne , Australia.

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting up to 18% women of reproductive age. It is associated with a range of metabolic, reproductive, and psychological features. Current evidence indicates a role of PCOS in the development of metabolic and increased cardiovascular risk factors (CVRF) with implications for compromised cardiovascular endpoint disease, which may have a considerable impact on health and health care costs. Read More

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December 2018

Gender difference of symptoms of acute coronary syndrome among Chinese patients: a cross-sectional study.

Eur J Cardiovasc Nurs 2018 Dec 17:1474515118820485. Epub 2018 Dec 17.

5 LinYi People's Hospital, Nursing Administrative Department, China.

Background:: The incidence of acute coronary syndrome is increasing in China.

Objective:: To investigate gender differences in Chinese patients' acute coronary syndrome symptoms, attribution of symptoms and reasons for seeking medical service.

Methods:: This was a cross-sectional, multicentre study. Read More

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December 2018

Diabetes Care and Management Using Electronic Medical Records: A Systematic Review.

J Diabetes Sci Technol 2018 Dec 17:1932296818815507. Epub 2018 Dec 17.

1 University of Massachusetts Boston, Boston, MA, USA.

Background:: Diabetes treatment and management provide a unique opportunity for examination of the effectiveness of electronic health records (EHRs) on patient health outcomes, continuity of care, and areas for further development. This systematic literature review was designed to identify the strengths and limitations of EHR and opportunities for improvement proposed in original research and recent rigorous systematic reviews.

Methods:: This review utilized methodology adapted from PRISMA. Read More

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December 2018

Trends in medication utilization, glycemic control and outcomes among type 2 diabetes patients in a tertiary referral centre in Singapore from 2007 to 2017.

J Diabetes 2018 Dec 16. Epub 2018 Dec 16.

Department of Rheumatology and Immunology, Singapore General Hospital.

Background: Use of glucose-lowering agents is a cornerstone in combating type 2 diabetes (T2DM). Treatment guidelines have changed significantly over the past decade. We report temporal trends in medication utilization, glycemic control, and rate of severe hypoglycemia in T2DM patients at a tertiary referral centre in Singapore. Read More

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December 2018

Cardiovascular risk profiling of long-lived people shows peculiar associations with mortality compared with younger individuals.

Geriatr Gerontol Int 2018 Dec 16. Epub 2018 Dec 16.

Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy.

Aim: Centenarians represent a biological model of successful aging because they escaped/postponed most invalidating age-related diseases, such as cardiovascular diseases. The aim of the present study was to clarify whether a favorable cardiovascular risk profile increases the survival chances in long-lived people.

Methods: A total of 355 community-dwelling nonagenarians and centenarians living in Southern Italy were recruited in the study. Read More

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December 2018
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