6,759 results match your criteria Diabetes research and clinical practice[Journal]


A high number of people have CVD, but do not know it.

Authors:
Pouya Saeedi

Diabetes Res Clin Pract 2019 Feb;148:270-271

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http://dx.doi.org/10.1016/j.diabres.2019.02.009DOI Listing
February 2019

Diabetes and Ramadan: a multicenter study in Algerian population.

Diabetes Res Clin Pract 2019 Feb 16. Epub 2019 Feb 16.

Department of internal medicine, Setif University Hospital, Algeria. Electronic address:

Objective: The aims of this study are to describe the behaviour of an Algerian population with diabetes and the consequences of fasting.

Methods: In 2017, a prospective multicenter study was conducted in 26 counties before and after fasting. The study concerned 901 patients with 836 type 2 diabetes mellitus (T2DM) and 65 with type 1 diabetes mellitus (T1DM). Read More

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http://dx.doi.org/10.1016/j.diabres.2019.02.008DOI Listing
February 2019

The Impact on Glycemic Control Through Progressive Resistance Training with bioDensity in Chinese Elderly Patients with Type 2 Diabetes: The PReTTy2 (Progressive Resistance Training in Type 2 Diabetes) Trial.

Diabetes Res Clin Pract 2019 Feb 16. Epub 2019 Feb 16.

Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai, People's Republic of China. Electronic address:

Aims: To evaluate the effects of a novel, low-volume, high-intensity Progressive Resistance Training (PRT) technique on blood glucose control in elderly Chinese patients with Type 2 Diabetes.

Materials And Methods: The PReTTy2 trial enrolled 300 male and female patients with Type 2 Diabetes in a randomized resistance training program with the bioDensity™ technique. 100 were control patients with no training intervention and 200 had resistance training. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.02.011DOI Listing
February 2019

Fibre-enriched buckwheat pasta modifies blood glucose response compared to corn pasta in individuals with type 1 diabetes and celiac disease: acute randomized controlled trial.

Diabetes Res Clin Pract 2019 Feb 16. Epub 2019 Feb 16.

Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy. Electronic address:

Aim: People with type 1 diabetes and celiac disease (T1D&CD) have high blood glucose variability. Processed gluten-free foods have shown to induce a worse metabolic profile whereas naturally gluten-free foods may represent healthier options. On the other hand, dietary fibre has shown to reduce postprandial glycemic excursions in individuals with diabetes. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.02.013DOI Listing
February 2019

Associations of insulin resistance with cognition in individuals without diagnosed diabetes: Results from the Hispanic Community Health Study/Study of Latinos.

Diabetes Res Clin Pract 2019 Feb 16. Epub 2019 Feb 16.

Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL; Department of Medicine, University of Illinois at Chicago, Chicago, IL; Rush Alzheimer's Disease Center and Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL. Electronic address:

Aims: Insulin resistance (IR) adversely impacts memory and executive functioning in non-Hispanic whites without diabetes. Less is known in Hispanics/Latinos, despite the fact that Hispanics/Latinos have higher rates of insulin resistance than non-Hispanic whites. We investigated the association between IR and cognition and its variation by age. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.030DOI Listing
February 2019

Safety and efficacy of lixisenatide versus sulfonylurea added to basal insulin treatment in people with type 2 diabetes mellitus who elect to fast during Ramadan (LixiRam): An international, randomized, open-label trial.

Diabetes Res Clin Pract 2019 Feb 14. Epub 2019 Feb 14.

University Hospital Birmingham & Institute of Translational Medicine, Edgbaston, Birmingham, UK. Electronic address:

Aims: Adding lixisenatide to basal insulin (BI) instead of sulfonylurea (SU), versus continuing SU + BI was assessed in people with type 2 diabetes mellitus (T2DM) who intended to fast during Ramadan 2017.

Methods: LixiRam (NCT02941367) was a phase 4, randomized, open-label, 12-22-week study in people with T2DM insufficiently controlled with SU + BI ± 1 oral anti-diabetic. Endpoints included the percentage of participants with ≥1 documented symptomatic hypoglycemia event (plasma glucose ≤70 mg/dL; primary endpoint) and any hypoglycemia during Ramadan fasting. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.035DOI Listing
February 2019

Diabetic Hypoglycaemia during Ramadan Fasting: A Trans-National Observational Real-World Study.

Diabetes Res Clin Pract 2019 Feb 14. Epub 2019 Feb 14.

Diabetes Unit, Amiri Hospital, Ministry of Health, Kuwait City, Kuwait. Electronic address:

Objectives: To describe the risk of hypoglycaemia during Ramadan and determine its risk factors, and the impact of hypoglycaemia on patients' behaviour.

Methods: A cross-sectional multi-country observational study, with data captured within 6 weeks after Ramadan 2015. Patients' and disease characteristics and its management, the risk of hypoglycaemia and patients' response to hypoglycaemia were recorded RESULTS: A cohort of 1759 patients; majority with type 2 diabetes mellitus from North Africa, Arabian Gulf, Saudi Arabia, and the Indian subcontinent. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.039DOI Listing
February 2019
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Assessment of risk of fasting during Ramadan under optimal diabetes care, in high-risk patients with diabetes and coronary heart disease through the use of FreeStyle Libre flash continuous glucose monitor (FSL-CGMS).

Diabetes Res Clin Pract 2019 Feb 13. Epub 2019 Feb 13.

Endocrine department, Dubai Hospital, United Arab Emirates.

Aim: Most of Muslims patients with diabetes and Coronary Heart Disease (CHD) elect to fast in Ramadan, but the actual risk in this subset of patients with diabetes is largely unknown. We aimed to understand the safety of fasting in CHD patients with diabetes insisting on fasting Ramadan under optimal care. We also monitored the change in biophysical and biochemical parameters of these patients before and after Ramadan. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.038DOI Listing
February 2019

Impact of optimum diabetes care on the safety of fasting in Ramadan in adult patients with type 2 diabetes mellitus on insulin therapy.

Diabetes Res Clin Pract 2019 Feb 12. Epub 2019 Feb 12.

Endocrine Department, Dubai Hospital, United Arab Emirates. Electronic address:

Aim: We aimed at evaluating the safety of fasting Ramadan for insulin treated type 2 diabetes patients by assessing the biochemical, biometric parameters, flash glucose monitoring (FGM) data as compared to pre-Ramadan and hospital admissions with diabetes or non-diabetes conditions. The risks of fasting between those treated with basal insulin vs intensive insulin during Ramadan was also assessed.

Methods: We included insulin treated patients with type 2 diabetes and we excluded those with co-morbidities. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.037DOI Listing
February 2019

Short-Term Effects of Intravitreal Bevacizumab in Contrast Sensitivity of Patients with Diabetic Macular Edema and Optimizing Glycemic Control.

Diabetes Res Clin Pract 2019 Feb 11. Epub 2019 Feb 11.

Division of Ophthalmology, University of São Paulo, São Paulo Medical School, São Paulo, Brazil.

Aims: To analyze contrast sensitivity of intravitreal bevacizumab injections with optimizing glycemic control versus optimizing glycemic control (in combination with sham injections) in eyes with diabetic macular edema (DME) DESIGN: Prospective, interventional, masked, randomized controlled trial.

Methods: Forty-one eyes of 34 patients with type 2 diabetes mellitus and DME with glycated hemoglobin (HbA1c) <11% received either intravitreal bevacizumab injection (Group 1) or sham injection (Group 2) at 0 and 6 weeks along with optimizing glycemic control. Mean change in best-corrected visual acuity (BCVA), contrast sensitivity (CS), optical coherence tomography (OCT)-measured by central macular thickness (CMT) were compared and correlated at baseline, 2, 6 and 12 weeks. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.02.002DOI Listing
February 2019

The effect of short-term intensive insulin therapy on circulating T cell subpopulations in patients with newly diagnosed type 2 diabetes mellitus.

Diabetes Res Clin Pract 2019 Feb 10;149:107-114. Epub 2019 Feb 10.

Department of Endocrinology, the Affiliated Nanjing Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Aims: To evaluate the effect of short-term intensive insulin therapy on circulating T cell subpopulations in patients with newly diagnosed type 2 diabetes mellitus (T2DM).

Methods: A total of 113 patients with T2DM and 28 normal subjects were enrolled. Demographic parameters and biochemical markers were collected at baseline, and flow cytometry was applied to determine the proportion of T cell subpopulations in participants. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.02.007DOI Listing
February 2019
2 Reads

Exenatide once-weekly improves metabolic parameters, endothelial dysfunction and carotid intima-media thickness in patients with type-2 diabetes: an 8-month prospective study.

Diabetes Res Clin Pract 2019 Feb 10. Epub 2019 Feb 10.

Biomedical Department of Internal Medicine and Specialties, University of Palermo, Italy; Division of Endocrinology, Diabetes and Metabolism, University of South Carolina School of Medicine, Columbia, South Carolina, USA.

Aim: To evaluate the effect of exenatide long acting release (LAR) on carotid intima-media thickness (IMT) and endothelial function in patients with type 2 diabetes mellitus.

Methods: Sixty subjects with type 2 diabetes mellitus were treated with exenatide LAR as add-on to stable doses of metformin for 8 months in an open label study. Anthropometric variables, lipid profile and glycemic parameters were assessed by routine analysis. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.02.006DOI Listing
February 2019
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Aspirin in people with diabetes: Time to clean up the prescription list?

Diabetes Res Clin Pract 2019 Feb 10. Epub 2019 Feb 10.

Department of Cardiology, Dupuytren University Hospital, Limoges, France.

The effect of aspirin in primary cardiovascular (CV) prevention in people with diabetes is still a matter of debate. Recent results of ASCEND trial suggest that the absolute benefit on CV events is largely counter-balanced by the bleeding risk. However, one crucial question is whether aspirin should be maintained or withdrawn from the prescription list of those who are already under this therapy since a while ago. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.02.005DOI Listing
February 2019
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Changes in the quality of diabetes care in Japan between 2007 and 2015: A repeated cross-sectional study using claims data.

Diabetes Res Clin Pract 2019 Feb 8. Epub 2019 Feb 8.

Diabetes and Metabolism Information Center, Research Institute, National Center for Global Health and Medicine, Japan; Department of Diabetes, Endocrinology and Metabolism, Center Hospital, National Center for Global Health and Medicine, Japan.

Aim: To assess the temporal changes in the quality indicators pertaining to the process measures of diabetes care during a recent decade in Japan.

Methods: A five-fold repeated cross-sectional study was conducted using health insurance claims data provided by the Japan Medical Data Center between April 2006 and March 2016. We identified 46,631 outpatients with antidiabetic medication who regularly visited hospitals or clinics at least every three months. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.02.001DOI Listing
February 2019

Psychometric evaluation of the summary of diabetes self-care activities measure in Ghanaian adults living with type 2 diabetes.

Diabetes Res Clin Pract 2019 Feb 8;149:98-106. Epub 2019 Feb 8.

School of Medicine and Public Health, University of Newcastle, University Drive, Callaghan, New South Wales 2308, Australia; Hunter Medical Research Institute, Locked Bag 1000, New Lambton, New South Wales 2305, Australia.

Aims: We evaluated the content validity, factorial structure, internal consistency, construct validity, and floor and ceiling effects of the SDSCA among Ghanaian persons with type 2 diabetes.

Methods: The summary of diabetes self-care activities measure (SDSCA) was administered to 187 adults living with type 2 diabetes from three diabetes clinics.

Results: A confirmatory factor analysis maintained the four factor structure of the SDSCA. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.02.004DOI Listing
February 2019
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Multidisciplinary diabetic foot care in Sweden - A national survey.

Diabetes Res Clin Pract 2019 Feb 7;149:126-131. Epub 2019 Feb 7.

Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute and Department of Radiology, Karolinska University Hospital, Huddinge, Sweden.

Aim: To investigate at a national level the multidisciplinary team (MDT) care of patients with diabetes mellitus and foot complications.

Methods: A questionnaire was sent to all 75 Swedish hospitals with emergency departments, which were grouped according to size.

Results: The response rate was 92%, 58/69 of the hospitals have a foot team. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.02.003DOI Listing
February 2019
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Validation of low-cost smartphone-based thermal camera for diabetic foot assessment.

Diabetes Res Clin Pract 2019 Feb 6;149:132-139. Epub 2019 Feb 6.

University of Twente, Drienerlolaan 5, 7522 NB Enschede, the Netherlands.

Aims: Infrared thermal imaging (IR) is not yet routinely implemented for early detection of diabetic foot ulcers (DFU), despite proven clinical effectiveness. Low-cost, smartphone-based IR-cameras are now available and may lower the threshold for implementation, but the quality of these cameras is unknown. We aim to validate a smartphone-based IR-camera against a high-end IR-camera for diabetic foot assessment. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.032DOI Listing
February 2019
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The association between gestational diabetes and postpartum depression: A systematic review and meta-analysis.

Diabetes Res Clin Pract 2019 Feb 5;149:147-155. Epub 2019 Feb 5.

School of Public Health, Ilam University of Medical Sciences, Ilam, Iran. Electronic address:

Aims: Postpartum period is a critical period for mothers, which is often accompanied by increased risk of depression. Many studies have evaluated the relationship between gestational diabetes (GDM) and postpartum depression (PPD), but contradictory results have been reported. Therefore, the present study was conducted to investigate the relationship between GDM and PPD. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.034DOI Listing
February 2019
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Cigarette smoking, type 2 diabetes mellitus, and glucagon-like peptide-1 receptor agonists as a potential treatment for smokers with diabetes: An integrative review.

Diabetes Res Clin Pract 2019 Feb 5;149:78-88. Epub 2019 Feb 5.

University of Texas Health Science Center at Houston, Houston, TX, United States.

Tobacco use disorder (TUD), in particular cigarette smoking, contributes significantly to the macro- and micro-vascular complications of type 2 diabetes mellitus (DM). Persons with DM who regularly use tobacco products are twice as likely to experience mortality and negative health outcomes. Despite these risks, TUD remains prevalent in persons with DM. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183173
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http://dx.doi.org/10.1016/j.diabres.2019.01.033DOI Listing
February 2019
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Relationships between blood pressure lowering therapy and cardiovascular events in hypertensive patients with coronary artery disease and type 2 diabetes mellitus: The HIJ-CREATE sub-study.

Diabetes Res Clin Pract 2019 Feb 6;149:69-77. Epub 2019 Feb 6.

Department of Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University, Japan.

Objective: The effects of intensive blood pressure (BP) lowering for hypertensive patients with coronary artery disease (CAD) and diabetes mellitus on their clinical outcomes have not been fully evaluated. The aim was to explore the optimal systolic BP target in such patients in a substudy of a prospective, randomized trial.

Methods: Of a total of 2049 hypertensive patients with CAD who were enrolled in the HIJ-CREATE study, type 2 diabetes was diagnosed in 780 (38. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.031DOI Listing
February 2019
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Effect of canagliflozin on the overall clinical state including insulin resistance in Japanese patients with type 2 diabetes mellitus.

Diabetes Res Clin Pract 2019 Feb 1;149:140-146. Epub 2019 Feb 1.

Department of Endocrinology and Metabolism, Yokohama City University School of Medicine, Yokohama, Japan. Electronic address:

Aims: Information on the clinical efficacy of SGLT2 inhibitors in the Japanese population is limited. The aim of this single-arm, single-center, open-label study was to confirm the body weight- and fat mass-lowering effects of canagliflozin (CANA) and the accompanying improvement in insulin resistance in Japanese patients with Type 2 diabetes mellitus (T2DM).

Methods: Thirty-eight patients were enrolled and administered 100 mg CANA once daily for 24 weeks. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.029DOI Listing
February 2019
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Serum lactate levels are associated with serum alanine aminotransferase and total bilirubin levels in patients with type 2 diabetes mellitus: A cross-sectional study.

Diabetes Res Clin Pract 2019 Jan 31;149:1-8. Epub 2019 Jan 31.

Third Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Kyorin University School of Medicine, Tokyo 181-8611, Japan.

Aims: It was recently reported that lactate acts as a metabolic mediator and rises in the diabetic state, but the physiological effects are as yet poorly understood. The objective of the current study was to evaluate the significance of serum lactate elevation in type 2 diabetes mellitus (T2DM) patients.

Methods: Fasting serum lactate levels, hematological and inflammatory serum markers and anthropometric parameters, obtained employing bioelectric impedance analysis, were measured in 103 patients with T2DM. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.028DOI Listing
January 2019

Clinical features, biochemistry and HLA-DRB1 status in youth-onset type 1 diabetes in Pakistan.

Diabetes Res Clin Pract 2019 Jan 30;149:9-17. Epub 2019 Jan 30.

Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA. Electronic address:

Published information on diabetes in Pakistani youth is limited. We aimed to investigate the demographic, clinical, and biochemical features, and HLA-DRB1 alleles in new cases of diabetes affecting children and adolescents <22 years of age. The study was conducted at Baqai Institute of Diabetology and Endocrinology in Karachi from June 2013-December 2015. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183148
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http://dx.doi.org/10.1016/j.diabres.2019.01.023DOI Listing
January 2019
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How does thiol/disulfide homeostasis change in children with type 1 diabetes mellitus?

Diabetes Res Clin Pract 2019 Jan 30;149:64-68. Epub 2019 Jan 30.

Yildirim Beyazit University, Department of Biochemistry, Ankara, Turkey.

Aims: An increase in reactive oxygen species leads to formation of covalent bonds between sulfur atoms, thus thiol/disulfide homeostasis shifts towards the disulfide direction and oxidative damage occurs. We aimed to determine thiol/disulfide homeostasis in children with T1DM.

Methods: Thiol/disulfide homeostasis was evaluated in 30 patients with T1DM and 30 age, gender matched healthy controls. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.027DOI Listing
January 2019
1 Read
2.538 Impact Factor

PAID-11: A brief measure of diabetes distress validated in adults with type 1 diabetes.

Diabetes Res Clin Pract 2019 Jan 30;149:27-38. Epub 2019 Jan 30.

School of Health Sciences, University of Nottingham, UK; National Institute for Health Research (NIHR) Biomedical Research Centre, Nottingham, UK.

Objective: The Problem Areas In Diabetes (PAID) questionnaire is widely used to assess emotional distress related to living with diabetes, although it is lengthy for routine clinical use. Our aim was to determine whether the original 20-item PAID questionnaire can be abbreviated, whilst maintaining its reliability, validity and utility.

Methods: We analysed data from the UK DAFNE (Dose Adjustment For Normal Eating) education programme for adults with Type 1 diabetes. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.026DOI Listing
January 2019

A safety and tolerability profile comparison between dipeptidyl peptidase-4 inhibitors and sulfonylureas in diabetic patients: A systematic review and meta-analysis.

Diabetes Res Clin Pract 2019 Jan 30;149:47-63. Epub 2019 Jan 30.

Women's Health Technology Assessment Center, Federal University of Sao Paulo (Universidade Federal de São Paulo), Sao Paulo, Brazil; AxiaBio Life Sciences, Sao Paulo, Brazil. Electronic address:

Background: The first treatment approach for type 2 diabetes mellitus is lifestyle change and metformin, but it is usually not sufficient. For some time, the anti-hyperglycemic classes of sulfonylureas and dipeptidyl peptidase-4 (DPP-4) inhibitors were considered second-line of treatment, since they show similar efficacy effect. However, the recent ADA-EASD consensus gives the preference to DPP-4 inhibitors compared to sulfonylureas, except if cost is a major problem. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.025DOI Listing
January 2019
5 Reads

Inadequate fat or carbohydrate intake was associated with an increased incidence of type 2 diabetes mellitus in Korean adults: A 12-year community-based prospective cohort study.

Diabetes Res Clin Pract 2019 Feb 28;148:254-261. Epub 2019 Jan 28.

Major of Food and Nutrition, School of Human Ecology, The Catholic University of Korea, Gyeonggi, Republic of Korea. Electronic address:

Aims: Few studies have focused on the relationship between long-term fat intake and type 2 diabetes mellitus (T2D) risk in Asia where fat intake is relatively lower than the Western countries. We examined association of dietary fat and carbohydrate intake with incidence of T2D among Korean adults.

Methods: Based on the data from the Korean Genome and Epidemiology Study, a total of 5595 adults aged 40-69 years without diabetes, cardiovascular diseases or any cancer at baseline were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183124
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http://dx.doi.org/10.1016/j.diabres.2019.01.024DOI Listing
February 2019
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The evaluation of thiol/disulphide homeostasis in diabetic nephropathy.

Diabetes Res Clin Pract 2019 Feb 26;148:249-253. Epub 2019 Jan 26.

Harran University, School of Medicine, Department of Endocrinology, Sanliurfa, Turkey.

Aims: Thiol/disulphide homeostasis plays a critical role in antioxidant defense, and detoxification in body. Although alteration of thiol/disulfide homeostasis had been shown in patients with diabetes, the thiol/disulfide balance in patients with type 2 diabetes and nephropathy is not yet known.

Methods: Twenty-six healthy volunteers (group 1), and 17 normal albuminuric (group 2), 24 middle albuminuric (group 3), 20 severe proteinuric (group 4) patients with type 2 diabetes were included. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.022DOI Listing
February 2019
1 Read
2.538 Impact Factor

Physician-patient communication at prescription of an additional oral drug for type 2 diabetes and its links to patient outcomes - New findings from the global IntroDia® study.

Diabetes Res Clin Pract 2019 Jan 24;149:89-97. Epub 2019 Jan 24.

Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Behavioral Diabetes Institute, 5405 Oberlin Drive, Suite 100, San Diego, CA 92121, USA. Electronic address:

Aims: To investigate experiences of people with type 2 diabetes (T2DM) at the clinic visit when an additional oral antidiabetes drug (OAD) is prescribed, and how this affects their quality of life, self-management and key outcomes.

Methods: We surveyed adults with T2DM from a large multinational study of patient-physician communication during early T2DM treatment (IntroDia®). We examined their experiences when an additional OAD is prescribed ("add-on") after initial OAD monotherapy, focusing on 24 key conversational elements, overall patient-perceived communication quality (PPCQ), and associations with current patient-reported outcomes. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.020DOI Listing
January 2019
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The incidence of diabetic ketoacidosis during Ramadan fasting: A 10-year single-centre retrospective study.

Diabetes Res Clin Pract 2019 Jan 24. Epub 2019 Jan 24.

Division of Endocrinology, Institute of Medicine, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates; Department of Medicine, Dubai Medical College, Dubai, United Arab Emirates.

Context: There has been an increased interest in the potential metabolic derangements and acute complications of diabetes related to the Muslims' fasting during the month of Ramadan.

Objectives: We compared the incidence of admissions due to diabetic ketoacidosis (DKA) during Ramadan with the admissions during other months.

Methods: This is a retrospective electronic database and chart review study that included all Muslims who were admitted with DKA to Sheikh Khalifa Medical City in Abu Dhabi, United Arab Emirates. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.018DOI Listing
January 2019
2 Reads
2.538 Impact Factor

Humanistic and economic burden of cardiovascular disease related comorbidities and hypoglycaemia among patients with type 2 diabetes in Japan.

Diabetes Res Clin Pract 2019 Jan 24;149:115-125. Epub 2019 Jan 24.

Medical Affairs, Sanofi K.K., Japan.

Aim: This study aims to examine the humanistic and economic burden of cardiovascular disease (CVD)-related comorbidities and hypoglycaemia among respondents with type 2 diabetes (T2D) in Japan.

Methods: This study used the Japan National Health and Wellness Survey 2016 database. Respondents who self-reported a physician-diagnosed T2D were included. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.019DOI Listing
January 2019
3 Reads

Impact of the definition of osteoarthritis and of the timing of its onset on the association between type 2 diabetes mellitus and osteoarthritis: Clinical Practice Research Datalink.

Diabetes Res Clin Pract 2019 Feb 24;148:240-248. Epub 2019 Jan 24.

Department of Pharmacoepidemiology & Clinical Pharmacology, Utrecht University, Utrecht, the Netherlands; Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Center+, Maastricht, the Netherlands. Electronic address:

Aims: In a previous case-control study in a large primary care database, the Clinical Practice Research Datalink (CPRD), type 2 diabetes mellitus (T2DM) was associated with a decreased rate of total joint replacement (TJR). As this was in contrast to the hypothesis, selection bias due to the used definition of osteoarthritis (OA) or misclassification of the onset of OA were raised as possible explanations. We therefore aimed to explore the effect of the definition of OA, and hypothesized timing of its onset on the association between T2DM and OA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183150
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http://dx.doi.org/10.1016/j.diabres.2019.01.021DOI Listing
February 2019
7 Reads

The prevalence of retinopathy in patients with type 1 diabetes treated with education-based intensified insulin therapy and its association with parameters of glucose control.

Diabetes Res Clin Pract 2019 Feb 23;148:234-239. Epub 2019 Jan 23.

Division of Endocrinology & Diabetes, Stadtspital Triemli, Zürich, Switzerland; Department Biosystems Science and Engineering (D-BSSE), ETH Zürich, Mattenstrasse 26, Basel, Switzerland; Faculty of Medicine, University of Basel, Switzerland. Electronic address:

Aim: Prevalence of retinopathy (DR) in patients with type 1 diabetes treated with education-based intensified insulin therapy (EBIIT) and its association with parameters of glucose control.

Methods: 151 patients with mean diabetes duration of 14.3 years [SD ± 5. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.016DOI Listing
February 2019
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Methylglyoxal, a potent inducer of AGEs, connects between diabetes and cancer.

Diabetes Res Clin Pract 2019 Feb 18;148:200-211. Epub 2019 Jan 18.

Metastasis Research Laboratory, GIGA-Cancer, University of Liège, Belgium. Electronic address:

Diabetes is one of the most frequent diseases throughout the world and its incidence is predicted to exponentially progress in the future. This metabolic disorder is associated with major complications such as neuropathy, retinopathy, atherosclerosis, and diabetic nephropathy, the severity of which correlates with hyperglycemia, suggesting that they are triggered by high glucose condition. Reducing sugars and reactive carbonyl species such as methylglyoxal (MGO) lead to glycation of proteins, lipids and DNA and the gradual accumulation of advanced glycation end products (AGEs) in cells and tissues. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.002DOI Listing
February 2019
9 Reads
2.538 Impact Factor

IDF's strategy to tackle eye complications in people with diabetes.

Authors:
Lisa Duke

Diabetes Res Clin Pract 2019 Jan;147:174-175

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http://dx.doi.org/10.1016/j.diabres.2019.01.013DOI Listing
January 2019
2 Reads

Patterns and trends in insulin initiation and intensification among patients with Type 2 diabetes mellitus in the Middle East and North Africa region.

Diabetes Res Clin Pract 2019 Jan 14;149:18-26. Epub 2019 Jan 14.

Eli Lilly and Company, Gurgaon, India.

Aim: Current and future estimates of the burden of diabetes in the Middle East and North Africa (MENA) region are among the highest in the world. VISION, an 18-month observational study, explored patterns of insulin initiation and intensification in T2DM patients in the MENA region.

Methods: 1192 patients aged ≥18 years were enrolled from Algeria, Egypt, Saudi Arabia and the UAE. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183138
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http://dx.doi.org/10.1016/j.diabres.2019.01.017DOI Listing
January 2019
13 Reads

Does sleep duration, napping, and social jetlag predict hemoglobin A1c among college students with type 1 diabetes mellitus?

Diabetes Res Clin Pract 2019 Feb 11;148:102-109. Epub 2019 Jan 11.

University of Delaware, Carpenter Sports Building, 26 North College Avenue, Newark, DE 19713, USA. Electronic address:

Aims: The first aim examined the relationship between sleep behaviors (duration, napping, and social jetlag) and hemoglobin A1c (HbA1c) among emerging young adults (EYAs) with T1DM between 18 and 25 years old, who are living on a college campus. The second aim characterized the gender differences in glucose management, sleep behaviors, caffeine intake, and nighttime technology.

Methods: A cross-sectional study of eligible participants used a convenience sample of eligible participants. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.007DOI Listing
February 2019
2 Reads

Physician experiences when discussing the need for additional oral medication with type 2 diabetes patients: Insights from the cross-national IntroDia® study.

Diabetes Res Clin Pract 2019 Feb 11;148:179-188. Epub 2019 Jan 11.

Rotherham Institute for Obesity, and Clifton Medical Centre, Doncaster Gate, Rotherham, South Yorkshire S65 1DA, United Kingdom. Electronic address:

Aims: Physician-patient communication when discussing the need for additional oral medication for type 2 diabetes (add-on) may affect the self-care of people with this condition. We aimed to investigate physicians' recalled experiences of the add-on consultation.

Methods: We conducted a cross-sectional survey of physicians treating people with type 2 diabetes in 26 countries, as part of a large cross-national study of physician-patient communication during early treatment of type 2 diabetes (IntroDia®). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183106
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http://dx.doi.org/10.1016/j.diabres.2019.01.012DOI Listing
February 2019
5 Reads

Association between postprandial hyperglycemia at clinic visits and all-cause and cancer mortality in patients with type 2 diabetes: A long-term historical cohort study in Japan.

Diabetes Res Clin Pract 2019 Feb 11;148:152-159. Epub 2019 Jan 11.

Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Aims: To evaluate the effect of postprandial hyperglycemia at clinic visits on all-cause and cancer mortality independent of glycated hemoglobin (HbA1c) levels in a real-world setting in Japanese patients with type 2 diabetes. We also investigated age at death.

Methods: This historical cohort study included 1582 patients with type 2 diabetes who first visited our clinic from 1995 to 1998 and continued visiting for at least 1 year. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183128
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http://dx.doi.org/10.1016/j.diabres.2019.01.006DOI Listing
February 2019
10 Reads

Plasma omentin levels are associated with vascular endothelial function in patients with type 2 diabetes at elevated cardiovascular risk.

Diabetes Res Clin Pract 2019 Feb 11;148:160-168. Epub 2019 Jan 11.

Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan; Vascular Science Center for Translational Research, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. Electronic address:

Aims: Omentin is an adipokine that has protective effects against cardiovascular damage. Previous studies showed an inverse relationship between omentin and obesity, diabetes, and cardiovascular disease. This study aimed to investigate the association between omentin and vascular endothelial function in patients with type 2 diabetes (T2D). Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.009DOI Listing
February 2019
2 Reads

Impact of maternal height and gestational diabetes mellitus on offspring birthweight.

Diabetes Res Clin Pract 2019 Feb 11;148:110-118. Epub 2019 Jan 11.

Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Folkhälsan Research Center, Helsinki, Finland; National Institute for Health and Welfare, Department of Chronic Disease Prevention, Helsinki, Finland; Singapore Institute for Clinical Sciences (SICS), Agency for Science and Technology (A*STAR), Singapore; Obstetrics & Gynecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.

Aims: To evaluate the impact of gestational diabetes mellitus (GDM) and maternal height on offspring birthweight.

Methods: This is an observational cohort study, encompassing 4 111 Finnish primiparous women from Vantaa city, Finland, with singleton deliveries between 2009 and 2015. Data were obtained from the Finnish Medical Birth Register. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.004DOI Listing
February 2019
2 Reads
2.538 Impact Factor

Clinical outcomes in patients with biopsy-proved diabetic nephropathy compared to isolated lupus or crescentic glomerulonephritis.

Diabetes Res Clin Pract 2019 Feb 11;148:144-151. Epub 2019 Jan 11.

Renal Division, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, No. 7, Chung Shan S. Rd., Zhongzheng Dist., Taipei City 10002, Taiwan. Electronic address:

Aims: Diabetic nephropathy (DMN) is usually diagnosed clinically without pathology, and the prognosis of which compared to non-diabetic renal diseases has rarely been investigated especially in ethnic Chinese population. Here we reported the outcome of patients with biopsy-proved DMN compared to those with isolated crescentic glomerulonephritis (GN) or lupus nephritis (LN).

Methods: This retrospective observational study included patients with DMN (n = 55), crescentic GN (n = 48) and LN (n = 82) from an original cohort of 987 adult patients who underwent kidney biopsy. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.014DOI Listing
February 2019
4 Reads

Reproducibility in the cardiometabolic responses to high-intensity interval exercise in adults with type 1 diabetes.

Diabetes Res Clin Pract 2019 Feb 11;148:137-143. Epub 2019 Jan 11.

LMC Diabetes and Endocrinology, 1929 Bayview Ave., Toronto, Ontario, Canada. Electronic address:

Aims: Patients with type 1 diabetes (T1D) often report a rise in their blood glucose level following brief intense exercise. We sought to determine the reproducibility of the cardiometabolic responses to high-intensity interval training (HIIT).

Methods: Sixteen adults with T1D, using an optimized multiple daily injection with basal insulin glargine 300 U/mL (Gla-300), performed four fasted HIIT sessions over a 4-6-week period. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183143
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http://dx.doi.org/10.1016/j.diabres.2019.01.003DOI Listing
February 2019
5 Reads

The role of optimum diabetes care in form of Ramadan focused diabetes education, flash glucose monitoring system and pre-Ramadan dose adjustments in the safety of Ramadan fasting in high risk patients with diabetes.

Diabetes Res Clin Pract 2019 Jan 11. Epub 2019 Jan 11.

Endocrine Department, Dubai Hospital, United Arab Emirates. Electronic address:

Background: Physiology of intermittent and prolonged fasting is known from healthy subjects. Evidence on high and very high-risk groups is lacking. The anticipated risks include hypoglycemia, hyperglycemia, dehydration and thrombosis. Read More

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http://dx.doi.org/10.1016/j.diabres.2018.12.013DOI Listing
January 2019
3 Reads

An observational, multicentre study on different insulin glargine U100 titration algorithms used in patients with type 2 diabetes in daily medical practice in Adriatic countries: the ADRESA study.

Diabetes Res Clin Pract 2019 Jan 11. Epub 2019 Jan 11.

Department of Endocrinology, Diabetes and Clinical Pharmacology Dubrava University Hospital, Zagreb, Croatia; School of Medicine, University of Zagreb, Croatia.

Aims: To compare the effectiveness of different titration algorithms for insulin glargine U100 used in everyday practice to achieve glycaemic targets in patients with type 2 diabetes mellitus (T2DM).

Methods: A total of 526 patients (278 in Slovenia, 248 in Croatia) with T2DM (aged ≥18 years) and treated with insulin glargine prior to inclusion were enrolled. Patients self-titrated insulin glargine according to physicians' guidance. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.001DOI Listing
January 2019
11 Reads

WITHDRAWN: HM47118A, a novel insulinotropic GPR119 agonist and potential oral antidiabetic agent.

Diabetes Res Clin Pract 2019 Jan 11. Epub 2019 Jan 11.

College of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Seoul 06974, Republic of Korea. Electronic address:

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183138
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http://dx.doi.org/10.1016/j.diabres.2019.01.011DOI Listing
January 2019
14 Reads

Evaluation of a program to improve intermediate diabetes outcomes in rural communities in the Dominican Republic.

Diabetes Res Clin Pract 2019 Feb 11;148:212-221. Epub 2019 Jan 11.

Creighton University, School of Medicine, Education Building, Suite 105, 7710 Mercy Road, Omaha, NE 68124, USA.

Aims: To describe implementation of diabetes and hypertension program in rural Dominican Republic (DR), and report six years of quality improvement process and health outcomes.

Methods: Dominican teams at two clinics are supported by Chronic Care International with: supervision and continuing education, electronic database, diabetes and hypertension protocols, medications, self-management education materials, behavior change techniques, and equipment and testing supplies (e.g. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183151
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http://dx.doi.org/10.1016/j.diabres.2019.01.010DOI Listing
February 2019
7 Reads

Conducting and interpreting results of network meta-analyses in type 2 diabetes mellitus: A review of network meta-analyses that include sodium glucose co-transporter 2 inhibitors.

Diabetes Res Clin Pract 2019 Feb 11;148:222-233. Epub 2019 Jan 11.

Janssen Global Services, LLC, Raritan, NJ, USA. Electronic address:

Aims: Network meta-analyses (NMAs) are valuable ways to generate comparative effectiveness data for therapies available to treat type 2 diabetes mellitus (T2DM). This review assesses NMAs that evaluate sodium glucose co-transporter 2 (SGLT2) inhibitors for treatment of T2DM and discusses potential issues in conducting and interpreting NMAs.

Methods: A systematic literature search was conducted on September 13, 2018 using the search terms "network meta-analysis," "SGLT2," variations of these terms, and individual SGLT2 inhibitor names. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183117
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http://dx.doi.org/10.1016/j.diabres.2019.01.005DOI Listing
February 2019
5 Reads

Diabetes-attributable mortality in the United States from 2003 to 2016 using a multiple-cause-of-death approach.

Diabetes Res Clin Pract 2019 Feb 11;148:169-178. Epub 2019 Jan 11.

Division of Primary Care and Population Health, Stanford University School of Medicine, Stanford, CA, United States.

Aims: Deaths attributable to diabetes may be underestimated using an underlying cause of death (COD) approach in U.S. death records. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.015DOI Listing
February 2019
2 Reads

Differential methylation of the type 2 diabetes susceptibility locus KCNQ1 is associated with insulin sensitivity and is predicted by CpG site specific genetic variation.

Diabetes Res Clin Pract 2019 Feb 11;148:189-199. Epub 2019 Jan 11.

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne NE1 7RU, UK; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol BS8 2BN, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK. Electronic address:

Aims: Epigenetic mechanisms regulate gene expression and may influence the pathogenesis of type 2 diabetes through the loss of insulin sensitivity. The aims of this study were to measure variation in DNA methylation at the type 2 diabetes locus KCNQ1 and assess its relationship with metabolic measures and with genotype.

Methods: DNA methylation from whole blood DNA was quantified using pyrosequencing at 5 CpG sites at the KCNQ1 locus in 510 individuals without diabetes from the 'Relationship between Insulin Sensitivity and Cardiovascular disease' (RISC) cohort. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.008DOI Listing
February 2019
3 Reads