16,820 results match your criteria Diabetes care[Journal]


Diabetes-Related Complications and Mortality in Patients With Young-Onset Latent Autoimmune Diabetes: A 14-Year Analysis of the Prospective Hong Kong Diabetes Register.

Diabetes Care 2019 Apr 9. Epub 2019 Apr 9.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.

Objective: Young-onset diabetes is heterogeneous in etiology and disease progression. We compared the incidence of diabetes-related complications and mortality in patients with young-onset type 2 diabetes with or without anti-GAD antibodies and patients with type 1 diabetes. We determined changes in glycemic control before and after commencement of insulin therapy stratified by antibody status. Read More

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-179
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http://dx.doi.org/10.2337/dc18-1796DOI Listing
April 2019
2 Reads

Efficacy of Fish Oil and/or Probiotic Intervention on the Incidence of Gestational Diabetes Mellitus in an At-Risk Group of Overweight and Obese Women: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial.

Diabetes Care 2019 Apr 9. Epub 2019 Apr 9.

Institute of Biomedicine, Integrative Physiology, and Pharmacology, University of Turku, Turku, Finland.

Objective: To assess whether the risk of gestational diabetes mellitus (GDM) may be lowered and glucose metabolism improved by daily administration of fish oil and/or probiotic supplements in overweight and obese pregnant women.

Research Design And Methods: We randomized in a double-blind manner 439 women (mean 13.9 ± 2. Read More

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http://dx.doi.org/10.2337/dc18-2591DOI Listing
April 2019
1 Read

Elevated Serum Uric Acid Is Associated With Greater Risk for Hypertension and Diabetic Kidney Diseases in Obese Adolescents With Type 2 Diabetes: An Observational Analysis From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study.

Diabetes Care 2019 Apr 9. Epub 2019 Apr 9.

University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO.

Objective: Elevated serum uric acid (SUA) is increasingly recognized as a risk factor for kidney disease in adults with diabetes, but data in youth are limited. We hypothesized that elevated SUA predicts development of elevated urinary albumin excretion (UAE) and hypertension over time in teens with type 2 diabetes (T2D).

Research Design And Methods: Serum creatinine, cystatin C, SUA, and the urine albumin-to-creatinine ratio (UACR) were assessed in 539 obese youth, ages 12-17 years, with T2D duration <2 years at baseline in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study. Read More

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http://dx.doi.org/10.2337/dc18-2147DOI Listing
April 2019
1 Read
8.420 Impact Factor

Glucose Variables in Type 1 Diabetes Studies With Dapagliflozin: Pooled Analysis of Continuous Glucose Monitoring Data From DEPICT-1 and -2.

Diabetes Care 2019 Apr 9. Epub 2019 Apr 9.

AstraZeneca, Mölndal, Sweden.

Objective: This pooled analysis assessed continuous glucose monitoring (CGM) in patients with inadequately controlled type 1 diabetes (HbA ≥7.7 to ≤11.0% [≥61 to ≤97 mmol/mol]) who received dapagliflozin as an adjunct to adjustable insulin. Read More

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-198
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http://dx.doi.org/10.2337/dc18-1983DOI Listing
April 2019
2 Reads

A Lack of Decline in Major Nontraumatic Amputations in Texas: Contemporary Trends, Risk Factor Associations, and Impact of Revascularization.

Diabetes Care 2019 Apr 9. Epub 2019 Apr 9.

Division of Cardiology, Department of Medicine, The University of Texas Health Science Center at San Antonio (UT Health San Antonio), San Antonio, TX

Objective: Nontraumatic major lower extremity amputations (LEAs) have been reported to be declining nationally; however, trends in Texas have been less well described. We evaluated demographic and clinical risk factors and revascularization associations for LEAs by using inpatient hospital discharge data in Texas from 2005 to 2014.

Research Design And Methods: Inpatient hospital discharge data were obtained from the Texas Center for Health Statistics. Read More

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http://dx.doi.org/10.2337/dc19-0078DOI Listing
April 2019
1 Read

Predicting Islet Cell Autoimmunity and Type 1 Diabetes: An 8-Year TEDDY Study Progress Report.

Diabetes Care 2019 Apr 9. Epub 2019 Apr 9.

Objective: Assessment of the predictive power of TEDDY-identified risk factors for islet autoimmunity (IA), the type of autoantibody appearing first, and type 1 diabetes (T1D).

Research Design And Methods: A total of 7,777 children were followed from birth to a median of 9.1 years of age for the development of islet autoantibodies and progression to T1D. Read More

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http://dx.doi.org/10.2337/dc18-2282DOI Listing

Heart Rate, Autonomic Function, and Future Changes in Glucose Metabolism in Individuals Without Diabetes: The Whitehall II Cohort Study.

Diabetes Care 2019 Apr 2. Epub 2019 Apr 2.

Steno Diabetes Center Copenhagen, Gentofte, Denmark.

Objective: Autonomic nervous system dysfunction is associated with impaired glucose metabolism, but the temporality of this association remains unclear in individuals without diabetes. We investigated the association of autonomic function with 5-year changes in glucose metabolism in individuals without diabetes.

Research Design And Methods: Analyses were based on 9,000 person-examinations for 3,631 participants without diabetes in the Whitehall II cohort. Read More

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http://dx.doi.org/10.2337/dc18-1838DOI Listing
April 2019
1 Read

The Economic Burden of Elevated Blood Glucose Levels in 2017: Diagnosed and Undiagnosed Diabetes, Gestational Diabetes, and Prediabetes.

Diabetes Care 2019 Apr 2. Epub 2019 Apr 2.

Lewin Group, Falls Church, VA.

Objective: This study was conducted to update national estimates of the economic burden of undiagnosed diabetes, prediabetes, and gestational diabetes in the United States for year 2017 and provide state-level estimates. Combined with published estimates for diagnosed diabetes, these updated statistics provide a detailed picture of the economic costs associated with elevated blood glucose levels.

Research Design And Methods: This study estimated medical expenditures exceeding levels occurring in the absence of diabetes or prediabetes and the indirect economic burden associated with reduced labor force participation and productivity. Read More

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http://dx.doi.org/10.2337/dc18-1226DOI Listing
April 2019
1 Read

Association Between Topical Corticosteroid Use and Type 2 Diabetes in Two European Population-Based Adult Cohorts.

Diabetes Care 2019 Apr 1. Epub 2019 Apr 1.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

Objective: Topical corticosteroids (CSs) are commonly used to treat inflammatory skin conditions including eczema and psoriasis. Although topical CS package inserts describe hyperglycemia and glycosuria as adverse drug reactions, it is unclear whether topical CS use in real life is also associated with an increased risk of type 2 diabetes (T2D).

Research Design And Methods: Two matched case-control studies and one cohort study were conducted using routinely collected health care data from Denmark and the U. Read More

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http://dx.doi.org/10.2337/dc18-2158DOI Listing
April 2019
1 Read

Early Intervention for Diabetes in Medical and Surgical Inpatients Decreases Hyperglycemia and Hospital-Acquired Infections: A Cluster Randomized Trial.

Diabetes Care 2019 Mar 28. Epub 2019 Mar 28.

Royal Melbourne Hospital, Parkville, Victoria, Australia

Objective: To investigate if early electronic identification and bedside management of inpatients with diabetes improves glycemic control in noncritical care.

Research Design And Methods: We investigated a proactive or early intervention model of care (whereby an inpatient diabetes team electronically identified individuals with diabetes and aimed to provide bedside management within 24 h of admission) compared with usual care (a referral-based consultation service). We conducted a cluster randomized trial on eight wards, consisting of a 10-week baseline period (all clusters received usual care) followed by a 12-week active period (clusters randomized to early intervention or usual care). Read More

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http://dx.doi.org/10.2337/dc18-2342DOI Listing
March 2019
4 Reads

The Effect of Liquid Meal Replacements on Cardiometabolic Risk Factors in Overweight/Obese Individuals With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Diabetes Care 2019 Mar 28. Epub 2019 Mar 28.

Toronto 3D (Diet, Digestive Tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Canada

Objective: The evidence for liquid meal replacements in diabetes has not been summarized. Our objective was to synthesize the evidence of the effect of liquid meal replacements on cardiometabolic risk factors in overweight/obese individuals with type 2 diabetes.

Research Design And Methods: Data sources included MEDLINE, EMBASE, and the Cochrane Library through 10 December 2018. Read More

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http://dx.doi.org/10.2337/dc18-2270DOI Listing

Comment on Lacy et al. Long-term Glycemic Control and Dementia Risk in Type 1 Diabetes. Diabetes Care 2018;41:2339-2345.

Diabetes Care 2019 Apr;42(4):e68

Endocrinology Division, Department of Internal Medicine, University Hospital "Dr. José E. González," Universidad Autónoma de Nuevo León, Monterrey, Mexico

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http://dx.doi.org/10.2337/dc18-2467DOI Listing
April 2019
8.420 Impact Factor

Response to Comment on Cheng et al. Trends and Disparities in Cardiovascular Mortality Among U.S. Adults With and Without Self-Reported Diabetes, 1988-2015. Diabetes Care 2018;41:2306-2315.

Diabetes Care 2019 Apr;42(4):e63

Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA.

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http://dx.doi.org/10.2337/dci18-0057DOI Listing

Ambulatory Blood Pressure Reduction With SGLT-2 Inhibitors: Dose-Response Meta-analysis and Comparative Evaluation With Low-Dose Hydrochlorothiazide.

Diabetes Care 2019 Apr;42(4):693-700

Division of Nephrology, Department of Medicine, Indiana University School of Medicine and Richard L. Roudebush VA Medical Center, Indianapolis, IN

Objective: Sodium-glucose cotransporter (SGLT)-2 inhibitors lower clinic and ambulatory blood pressure (BP), possibly through their natriuretic action. However, it remains unclear whether this BP-lowering effect is dose dependent and different from that of low-dose hydrochlorothiazide. The purpose of this meta-analysis was to quantify the association of the dose with response of ambulatory BP to SGLT-2 inhibition and to provide comparative evaluation with low-dose hydrochlorothiazide. Read More

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http://dx.doi.org/10.2337/dc18-2207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429633PMC

Elizabeth Barrett-Connor: Instrumental Contributor to the Understanding of Midlife Well-being and Health in Both Women and Men.

Authors:
Kay-Tee Khaw

Diabetes Care 2019 Apr;42(4):502-506

University of Cambridge, Cambridge, U.K.

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http://dx.doi.org/10.2337/dci19-0004DOI Listing

More Evidence for a Prevention-Related Indication for Metformin: Let the Arguments Resume!

Diabetes Care 2019 Apr;42(4):499-501

Oregon Health & Science University, Portland, OR.

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http://dx.doi.org/10.2337/dci18-0062DOI Listing

In This Issue of .

Authors:

Diabetes Care 2019 Apr;42(4):497-498

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http://dx.doi.org/10.2337/dc19-ti04DOI Listing

Mediation of the Effect of Glycemia on the Risk of CVD Outcomes in Type 1 Diabetes: The DCCT/EDIC Study.

Diabetes Care 2019 Mar 20. Epub 2019 Mar 20.

Biostatistics Center, The George Washington University, Rockville, MD.

Objective: The Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) study has demonstrated the major role of hyperglycemia as a risk factor for clinical cardiovascular outcomes in type 1 diabetes (T1D). We assessed whether and to what extent the effect of glycemia is mediated by other established cardiovascular disease (CVD) risk factors.

Research Design And Methods: In the DCCT, 1,441 participants were randomized to receive either intensive or conventional diabetes therapy. Read More

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http://dx.doi.org/10.2337/dc18-1613DOI Listing

The SGLT2 Inhibitor Dapagliflozin Reduces Liver Fat but Does Not Affect Tissue Insulin Sensitivity: A Randomized, Double-Blind, Placebo Controlled Study With 8-Week Treatment in Type 2 Diabetes Patients.

Diabetes Care 2019 Mar 18. Epub 2019 Mar 18.

Turku PET Centre, University of Turku, Turku, Finland

Objective: The aim of this study was to investigate tissue-specific effects of dapagliflozin on insulin sensitivity and liver and body fat in patients with type 2 diabetes.

Research Design And Methods: This randomized, double-blind, parallel group, placebo-controlled study recruited 32 patients with type 2 diabetes. Enrolled patients were to have HbA 6. Read More

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http://dx.doi.org/10.2337/dc18-1569DOI Listing
March 2019
1 Read

Soluble Urokinase Plasminogen Activator Receptor Predicts Cardiovascular Events, Kidney Function Decline, and Mortality in Patients With Type 1 Diabetes.

Diabetes Care 2019 Mar 18. Epub 2019 Mar 18.

Steno Diabetes Center Copenhagen, Gentofte, Denmark.

Objective: Soluble urokinase plasminogen activator receptor (suPAR) is an important inflammatory biomarker implicated in endothelial and podocyte dysfunction. However, suPAR's predictive qualities for complications in type 1 diabetes have yet to be determined. We investigated the prognostic value of suPAR for the development of cardiovascular events, decline in renal function, and mortality in patients with type 1 diabetes. Read More

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http://dx.doi.org/10.2337/dc18-1427DOI Listing
March 2019
2 Reads

Sex Differences in Treatment With ACE Inhibitors and Angiotensin Receptor Blockers in Type 1 Diabetes Patients.

Diabetes Care 2019 Mar 18. Epub 2019 Mar 18.

Pediatrics, Department of Clinical Sciences, Umeå University, Umeå, Sweden.

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http://dx.doi.org/10.2337/dc18-2542DOI Listing

Biochemical Urine Testing of Adherence to Cardiovascular Medications Reveals High Rates of Nonadherence in People Attending Their Annual Review for Type 2 Diabetes.

Diabetes Care 2019 Mar 18. Epub 2019 Mar 18.

Leicester Diabetes Centre, Leicester General Hospital, Leicester, U.K.

Objective: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a new method to objectively and robustly detect nonadherence. We applied this technique to study nonadherence to cardiovascular medications in people with type 2 diabetes (T2DM).

Research Design And Methods: Routine urine samples, received at the time of the annual diabetes review from 228 people with T2DM in primary care, were assessed for adherence by LC-MS/MS. Read More

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http://dx.doi.org/10.2337/dc18-1453DOI Listing
March 2019
1 Read

Variation in the Plasma Membrane Monoamine Transporter (PMAT, Encoded in ) and Organic Cation Transporter 1 (OCT1, Encoded in ) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study.

Diabetes Care 2019 Mar 18. Epub 2019 Mar 18.

Objective: Gastrointestinal adverse effects occur in 20-30% of patients with metformin-treated type 2 diabetes, leading to premature discontinuation in 5-10% of the cases. Gastrointestinal intolerance may reflect localized high concentrations of metformin in the gut. We hypothesized that reduced transport of metformin via the plasma membrane monoamine transporter (PMAT) and organic cation transporter 1 (OCT1) could increase the risk of severe gastrointestinal adverse effects. Read More

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http://dx.doi.org/10.2337/dc18-2182DOI Listing
March 2019
1 Read
8.420 Impact Factor

Uric Acid is an Independent Risk Factor for Decline in Kidney Function, Cardiovascular Event and Mortality in Patients With Type 1 Diabetes.

Diabetes Care 2019 Mar 18. Epub 2019 Mar 18.

Steno Diabetes Center Copenhagen, Gentofte, Denmark.

Objective: Previous studies have provided inconclusive results on the role of uric acid (UA) in risk prediction. Here we aimed to improve the power and precision of the predictive value of UA for the risk of decline in kidney function, cardiovascular events (CVEs), and mortality in patients with type 1 diabetes (T1D).

Research Design And Methods: Plasma UA was measured in 670 patients with T1D and various degrees of albuminuria, ranging from normoalbuminuria to macroalbuminuria. Read More

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-217
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http://dx.doi.org/10.2337/dc18-2173DOI Listing
March 2019
3 Reads

Long-term Effects of Metformin on Diabetes Prevention: Identification of Subgroups That Benefited Most in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study.

Authors:

Diabetes Care 2019 Apr;42(4):601-608

Objective: We examined the effects of metformin on diabetes prevention and the subgroups that benefited most over 15 years in the Diabetes Prevention Program (DPP) and its follow-up, the Diabetes Prevention Program Outcomes Study (DPPOS).

Research Design And Methods: During the DPP (1996-2001), adults at high risk of developing diabetes were randomly assigned to masked placebo ( = 1,082) or metformin 850 mg twice daily ( = 1,073). Participants originally assigned to metformin continued to receive metformin, unmasked, in the DPPOS (2002-present). Read More

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http://dx.doi.org/10.2337/dc18-1970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429636PMC

Early Detection of Hypoglycemia in Type 1 Diabetes Using Heart Rate Variability Measured by a Wearable Device.

Diabetes Care 2019 Apr;42(4):689-692

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

Objective: Changes in heart rate variability (HRV) occur at the initiation of hypoglycemia due to sympathetic nervous system activity. We investigated the use of HRV detection by a wearable device as an early alert for hypoglycemia.

Research Design And Methods: This proof-of-principle study included 23 patients with type 1 diabetes (14 women, mean age 42 ± 11 years). Read More

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http://dx.doi.org/10.2337/dc18-1843DOI Listing
April 2019
1 Read

Comparative Effectiveness and Maintenance of Diabetes Self-Management Education Interventions for Marshallese Patients With Type 2 Diabetes: A Randomized Controlled Trial.

Diabetes Care 2019 Mar 12. Epub 2019 Mar 12.

College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR.

Objective: Marshallese adults experience high rates of type 2 diabetes. Previous diabetes self-management education (DSME) interventions among Marshallese were unsuccessful. This study compared the extent to which two DSME interventions improved glycemic control, measured on the basis of change in glycated hemoglobin (HbA). Read More

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http://dx.doi.org/10.2337/dc18-1985DOI Listing

Efficacy and Safety of Empagliflozin in Renal Transplant Recipients With Posttransplant Diabetes Mellitus.

Diabetes Care 2019 Mar 12. Epub 2019 Mar 12.

Department of Transplantation Medicine, Section of Nephrology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Objective: Sodium-glucose cotransporter 2 (SGLT2) inhibitors have lately become the recommended treatment in patients with type 2 diabetes and high cardiovascular risk. Patients with posttransplant diabetes mellitus (PTDM) also have high cardiovascular risk. The aim of this study was to investigate the safety and efficacy of empagliflozin in renal transplant recipients with PTDM. Read More

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http://dx.doi.org/10.2337/dc19-0093DOI Listing

Risk of Incident Obstructive Sleep Apnea Among Patients With Type 2 Diabetes.

Diabetes Care 2019 Mar 12. Epub 2019 Mar 12.

Institute of Applied Health Research, University of Birmingham, Birmingham, U.K.

Objective: This study compared the incidence of obstructive sleep apnea (OSA) in patients with and without type 2 diabetes and investigated risk factors for OSA in patients with type 2 diabetes.

Research Design And Methods: A retrospective cohort study was performed to compare OSA incidence between adult patients with and without type 2 diabetes matched for age, sex, and BMI. Patients with a prevalent OSA diagnosis were excluded. Read More

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-200
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http://dx.doi.org/10.2337/dc18-2004DOI Listing
March 2019
7 Reads

Disordered Eating Behaviors in Youth and Young Adults With Type 1 or Type 2 Diabetes Receiving Insulin Therapy: The SEARCH for Diabetes in Youth Study.

Diabetes Care 2019 Mar 12. Epub 2019 Mar 12.

Objective: This study examines the prevalence of disordered eating behaviors (DEB) and its associations with glycemic control, insulin sensitivity (IS), and psychosocial functioning in a large, diverse cohort of youth and young adults with type 1 or type 2 diabetes.

Research Design And Methods: In the SEARCH for Diabetes in Youth study, 2,156 youth and young adults with type 1 diabetes (mean ± SD age 17.7 ± 4. Read More

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http://dx.doi.org/10.2337/dc18-2420DOI Listing
March 2019
2 Reads

Intractable Coronary Artery Disease in a Patient with Type 2 Diabetes Presenting With Triglyceride Deposit Cardiomyovasculopathy.

Diabetes Care 2019 Mar 12. Epub 2019 Mar 12.

Laboratory of Cardiovascular Disease, Novel, Non-invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University, Osaka, Japan

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http://dx.doi.org/10.2337/dc18-2365DOI Listing

Underuse of Medications and Lifestyle Counseling to Prevent Cardiovascular Disease in Patients With Diabetes.

Diabetes Care 2019 Mar 12. Epub 2019 Mar 12.

Division of General Internal Medicine and Health Services Research, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA.

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http://dx.doi.org/10.2337/dc18-1554DOI Listing
March 2019
1 Read

Post-ACA Racial Disparity of Eye Examinations Among the U.S. Noninstitutionalized Population With Diabetes: 2014-2015.

Diabetes Care 2019 Mar 12. Epub 2019 Mar 12.

Department of Global Health Management and Policy, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA

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http://dx.doi.org/10.2337/dc18-1991DOI Listing
March 2019
1 Read

Dysglycemia and the Density of the Coronary Vasa Vasorum.

Diabetes Care 2019 Mar 12. Epub 2019 Mar 12.

Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Canada.

Objective: This study was conducted to determine the relationship between dysglycemia and the coronary artery vasa vasorum density.

Research Design And Methods: The left anterior descending coronary artery was removed from 57 deceased individuals during autopsy, and the capillaries in the vessel wall were identified using fluorescent immunohistochemical staining. HbA was determined in postmortem whole blood for each individual. Read More

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-248
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http://dx.doi.org/10.2337/dc18-2483DOI Listing
March 2019
7 Reads

Testosterone Therapy in Men With Hypogonadism Prevents Progression From Prediabetes to Type 2 Diabetes: Eight-Year Data From a Registry Study.

Diabetes Care 2019 Mar 12. Epub 2019 Mar 12.

Department of Nutrition Sciences, University of Alabama at Birmingham and the Birmingham VA Medical Center, Birmingham, AL.

Objective: Type 2 diabetes (T2D) is a public health threat. Prediabetes represents a window of opportunity for intervention to prevent T2D. Men with T2D and prediabetes often have low testosterone. Read More

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http://dx.doi.org/10.2337/dc18-2388DOI Listing
March 2019
2 Reads

Nonadherence to Insulin Therapy Detected by Bluetooth-Enabled Pen Cap Is Associated With Poor Glycemic Control.

Diabetes Care 2019 Mar 12. Epub 2019 Mar 12.

Joslin Diabetes Center, Boston, MA.

Objective: To objectively evaluate adherence to timing and dosing of insulin by using Bluetooth pen caps and examine factors related to adherence.

Research Design And Methods: Bluetooth-enabled insulin pen caps were used in younger (ages 18-35 years) and older (ages ≥65 years) adults on two or more insulin injections per day.

Results: We evaluated 75 participants with diabetes, 42 younger (29 ± 4 years) and 33 older (73 ± 7 years). Read More

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http://dx.doi.org/10.2337/dc18-1631DOI Listing
March 2019
1 Read

Self-Monitoring of Blood Glucose in Youth-Onset Type 2 Diabetes: Results From the TODAY Study.

Diabetes Care 2019 Mar 4. Epub 2019 Mar 4.

University of Colorado School of Medicine, Aurora, CO.

Objective: To determine whether self-monitoring of blood glucose (SMBG) is associated with lower HbA in youth with type 2 diabetes taking oral medications only or after starting insulin for persistently elevated HbA.

Research Design And Methods: TODAY participants ( = 699) taking oral medications were asked to perform SMBG twice daily. After reaching primary outcome (PO) (HbA ≥8% [64 mmol/mol]) over 6 months or an inability to wean from temporary insulin because of metabolic decompensation), insulin glargine was started. Read More

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http://dx.doi.org/10.2337/dc18-1854DOI Listing
March 2019
3 Reads

Importance of Treatment Status in Links Between Type 2 Diabetes and Alzheimer Disease.

Diabetes Care 2019 Mar 4. Epub 2019 Mar 4.

Department of Psychology, University of Southern California, Los Angeles, CA

Objective: To investigate relationships among type 2 diabetes treatment, Alzheimer disease biomarkers, and risk for dementia.

Research Design And Methods: Participants from the Alzheimer Disease Neuroimaging Initiative ( = 1,289) who were dementia-free at baseline and underwent health assessment, cognitive testing, and MRI. A subset ( = 900) obtained a lumbar puncture to determine cerebrospinal fluid (CSF) phosphorylated tau (p-tau), total tau (t-tau), and β-amyloid 1-42 (Aβ1-42). Read More

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http://dx.doi.org/10.2337/dc18-1399DOI Listing
March 2019
2 Reads

Long-term Association of Depression Symptoms and Antidepressant Medication Use With Incident Cardiovascular Events in the Look AHEAD (Action for Health in Diabetes) Clinical Trial of Weight Loss in Type 2 Diabetes.

Diabetes Care 2019 Mar 4. Epub 2019 Mar 4.

National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.

Objective: To examine whether depression symptoms or antidepressant medication (ADM) use predicts the probability of cardiovascular events in overweight/obese individuals with type 2 diabetes.

Research Design And Methods: Preplanned analyses of depression and incident cardiovascular disease (CVD) were performed in the Look AHEAD (Action for Health in Diabetes) weight loss trial after a median follow-up of 9.6 years. Read More

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http://dx.doi.org/10.2337/dc18-0575DOI Listing

Nonproteinuric Versus Proteinuric Phenotypes in Diabetic Kidney Disease: A Propensity Score-Matched Analysis of a Nationwide, Biopsy-Based Cohort Study.

Diabetes Care 2019 Mar 4. Epub 2019 Mar 4.

Nephrology Center, Toranomon Hospital Kajigaya, Kanagawa, Japan.

Objective: Clinicopathological characteristics, renal prognosis, and mortality in patients with type 2 diabetes and reduced renal function without overt proteinuria are scarce.

Research Design And Methods: We retrospectively assessed 526 patients with type 2 diabetes and reduced renal function (estimated glomerular filtration rate [eGFR] <60 mL/min/1.73 m), who underwent clinical renal biopsy and had follow-up data, from Japan's nationwide multicenter renal biopsy registry. Read More

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http://dx.doi.org/10.2337/dc18-1320DOI Listing
March 2019
9 Reads