16,741 results match your criteria Diabetes care[Journal]


Diagnostic Accuracy of a Device for the Automated Detection of Diabetic Retinopathy in a Primary Care Setting.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, the Netherlands.

Objective: To determine the diagnostic accuracy in a real-world primary care setting of a deep learning-enhanced device for automated detection of diabetic retinopathy (DR).

Research Design And Methods: Retinal images of people with type 2 diabetes visiting a primary care screening program were graded by a hybrid deep learning-enhanced device (IDx-DR-EU-2.1; IDx, Amsterdam, the Netherlands), and its classification of retinopathy (vision-threatening [vt]DR, more than mild [mtm]DR, and mild or more [mom]DR) was compared with a reference standard. Read More

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http://dx.doi.org/10.2337/dc18-0148DOI Listing
February 2019

Antisense Inhibition of Glucagon Receptor by IONIS-GCGR Improves Type 2 Diabetes Without Increase in Hepatic Glycogen Content in Patients With Type 2 Diabetes on Stable Metformin Therapy.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Ionis Pharmaceuticals, Inc., Carlsbad, CA

Objective: To evaluate the safety and efficacy of IONIS-GCGR, a 2'--methoxyethyl antisense oligonucleotide targeting the glucagon receptor (GCGR), and the underlying mechanism of liver transaminase increases in patients with type 2 diabetes on stable metformin therapy.

Research Design And Methods: In three phase 2, randomized, double-blind studies, patients with type 2 diabetes on metformin received weekly subcutaneous injections of IONIS-GCGR (50-200 mg) or placebo for 13 or 26 weeks.

Results: Significant reductions in HbA were observed after IONIS-GCGR treatment versus placebo at week 14 (-2. Read More

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http://dx.doi.org/10.2337/dc18-1343DOI Listing
February 2019

Occurrence of Diabetic Nephropathy After Renal Transplantation Despite Intensive Glycemic Control: An Observational Cohort Study.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Laboratory of Nephrology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium

Objective: The kinetics and risk factors of diabetic nephropathy after kidney transplantation remain unclear. This study investigated the posttransplant occurrence of diabetic nephropathy and the contribution of posttransplant glycemic control.

Research Design And Methods: We performed a single-center prospective cohort study of 953 renal allograft recipients and 3,458 protocol-specified renal allograft biopsy specimens up to 5 years after transplantation. Read More

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http://dx.doi.org/10.2337/dc18-1936DOI Listing
February 2019

Effect of a Behavioral Weight Loss Intervention in People With Serious Mental Illness and Diabetes.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Division of General Internal Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD.

Objective: Given the high prevalence of obesity and diabetes in patients with serious mental illness (SMI) and the lack of evidence on the effects of weight loss programs in SMI patients with diabetes, we evaluated the effectiveness of a behavioral weight loss intervention among SMI participants with and without diabetes.

Research Design And Methods: Using data from ACHIEVE, a randomized controlled trial to evaluate the effects of a behavioral weight loss intervention among overweight/obese people with SMI, we assessed and compared weight change from baseline to 18 months in participants with and without diabetes using a longitudinal mixed-effects model.

Results: Of the 291 trial participants, 82 (28. Read More

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http://dx.doi.org/10.2337/dc18-2201DOI Listing
February 2019

Overall Quality of Care Predicts the Variability of Key Risk Factors for Complications in Type 2 Diabetes: An Observational, Longitudinal Retrospective Study.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Objective: An association between variability in clinical parameters (HbA, blood pressure, cholesterol, and uric acid) and risk of complications in type 2 diabetes has been reported. In this analysis, we investigated to what extent such variability is associated with overall quality of care.

Research Design And Methods: The quality of care summary score (Q-score) represents a validated, overall quality of care indicator ranging between 0 and 40; the higher the score, the better the quality of care provided by the diabetes center. Read More

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http://dx.doi.org/10.2337/dc18-1471DOI Listing
February 2019

Major Adverse Cardiovascular Events Following Simultaneous Pancreas and Kidney Transplantation in the United Kingdom.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Department of Renal and Pancreatic Transplantation, Manchester University NHS Foundation Trust, Manchester, U.K.

Objective: People with type 1 diabetes and kidney failure have an increased risk for major adverse cardiovascular events (MACE). Simultaneous pancreas and kidney transplantation (SPKT) improves survival, but the long-term risk for MACE is uncertain.

Research Design And Methods: We assessed the frequency and risk factors for MACE (defined as fatal cardiovascular disease and nonfatal myocardial infarction or stroke) and related nonfatal MACE to allograft failure in SPKT recipients with type 1 diabetes who underwent transplantation between 2001 and 2015 in the U. Read More

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-211
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http://dx.doi.org/10.2337/dc18-2111DOI Listing
February 2019
1 Read

Diabetes Distress, Intentional Hyperglycemia at Work, and Glycemic Control Among Workers With Type 1 Diabetes.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Diabetes Management Research, Steno Diabetes Center Copenhagen, Gentofte, Denmark

Objective: The aim was to explore relationships between work-related factors, work-related diabetes distress (WRDD), diabetes distress (measured by Problem Areas in Diabetes [PAID]-5 scale), intentional hyperglycemia at work (IHW), and glycemic control.

Research Design And Methods: A cross-sectional survey was conducted with 1,030 working adults with type 1 diabetes and linked with electronic health record data from a specialist diabetes clinic in Denmark. With use of structural equation modeling, two alternative models were compared, based on fit indices, statistical significance, and theoretical meaningfulness. Read More

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http://dx.doi.org/10.2337/dc18-1426DOI Listing
February 2019

Comparative Effects of Proximal and Distal Small Intestinal Glucose Exposure on Glycemia, Incretin Hormone Secretion, and the Incretin Effect in Health and Type 2 Diabetes.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Adelaide Medical School and Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia

Objective: Cells releasing glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are distributed predominately in the proximal and distal gut, respectively. Hence, the region of gut exposed to nutrients may influence GIP and GLP-1 secretion and impact on the incretin effect and gastrointestinal-mediated glucose disposal (GIGD). We evaluated glycemic and incretin responses to glucose administered into the proximal or distal small intestine and quantified the corresponding incretin effect and GIGD in health and type 2 diabetes mellitus (T2DM). Read More

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http://dx.doi.org/10.2337/dc18-2156DOI Listing
February 2019

Suboptimal Nocturnal Glucose Control Is Associated With Large for Gestational Age in Treated Gestational Diabetes Mellitus.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Division of Clinical and Population Sciences, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, U.K.

Objective: Continuous glucose monitoring (CGM) provides far greater detail about fetal exposure to maternal glucose across the 24-h day. Our aim was to examine the role of temporal glucose variation on the development of large for gestational age (LGA) infants in women with treated gestational diabetes mellitus (GDM).

Research Design And Methods: We performed a prospective observational study of 162 pregnant women with GDM in specialist multidisciplinary antenatal diabetes clinics. Read More

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http://dx.doi.org/10.2337/dc18-2212DOI Listing
February 2019

Revalidation of the Hypoglycemia Risk Stratification Tool Using ICD-10 Codes.

Diabetes Care 2019 Feb 14. Epub 2019 Feb 14.

Section of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT.

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-215
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http://dx.doi.org/10.2337/dc18-2154DOI Listing
February 2019
1 Read

Seasonal Variations in the Achievement of Guideline Targets for HbA1c, Blood Pressure, and Cholesterol Among Type 2 Diabetic Patients: A Nationwide Population-Based Study (ABC study) (JDDM49).

Diabetes Care 2019 Feb 10. Epub 2019 Feb 10.

Clinical Research Support Center, The Jikei University School of Medicine, Tokyo, Japan, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.

Objective: Precise monthly achievement rates for reaching guideline targets for HbA1c, blood pressure (BP), and lipid levels remain unknown. We evaluated achievement rates on a monthly basis in persons with type 2 diabetes mellitus (T2DM) and explored related factors.

Research Design And Methods: This retrospective study initially analyzed data on 104,601 persons with T2DM throughout Japan. Read More

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http://dx.doi.org/10.2337/dc18-1953DOI Listing
February 2019
1 Read

International Consensus on Risk Management of Diabetic Ketoacidosis in Patients with Type 1 Diabetes Treated with Sodium-Glucose Cotransporter (SGLT) Inhibitors.

Diabetes Care 2019 Feb 6. Epub 2019 Feb 6.

Diabetes Centre for Children and Adolescents, AUF DER BULT, Kinder- und Jugendkrankenhaus, Hannover, Germany.

Sodium glucose cotransporter (SGLT) inhibitors are new oral antidiabetic medications shown to effectively reduce glycated hemoglobin (A1C) and glycemic variability, blood pressure and body weight without intrinsic properties to cause hypoglycemia in people with type 1 diabetes. However, recent studies, particularly in individuals with type 1 diabetes, have demonstrated increases in the absolute risk of diabetic ketoacidosis (DKA). Some cases presented with near-normal blood glucose levels or mild hyperglycemia, complicating the recognition/diagnosis of DKA and potentially delaying treatment. Read More

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-231
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http://dx.doi.org/10.2337/dc18-2316DOI Listing
February 2019
5 Reads

Association of Diabetes and Glycated Hemoglobin With the Risk of Intracerebral Hemorrhage: A Population-Based Cohort Study.

Diabetes Care 2019 Feb 6. Epub 2019 Feb 6.

Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel

Objective: To examine the association of diabetes and glycated hemoglobin (HbA) with the risk of intracerebral hemorrhage (ICH) in a large population-based cohort.

Research Design And Methods: The computerized database of the largest health care provider in Israel was used to identify adult members aged 40 years or older and alive at 1 January 2010 (297,486 with diabetes and 1,167,585 without diabetes). The cohort was followed until 31 December 2017 for incidence of ICH. Read More

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http://dx.doi.org/10.2337/dc18-2472DOI Listing
February 2019

Glycemic Variability Is a Powerful Independent Predictive Factor of Midterm Major Adverse Cardiac Events in Patients With Diabetes With Acute Coronary Syndrome.

Diabetes Care 2019 Feb 6. Epub 2019 Feb 6.

Endocrinology-Metabolic Diseases, Hôpital Saint-André, Bordeaux University, Bordeaux, France

Objective: Acute glucose fluctuations are associated with hypoglycemia and are emerging risk factors for cardiovascular outcomes. However, the relationship between glycemic variability (GV) and the occurrence of midterm major cardiovascular events (MACE) in patients with diabetes remains unclear. This study investigated the prognostic value of GV in patients with diabetes and acute coronary syndrome (ACS). Read More

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-204
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http://dx.doi.org/10.2337/dc18-2047DOI Listing
February 2019
5 Reads

Glucose Management Indicator (GMI): Insights and Validation Using Guardian 3 and Navigator 2 Sensor Data.

Diabetes Care 2019 Feb 6. Epub 2019 Feb 6.

Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, U.K.

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http://dx.doi.org/10.2337/dc18-2479DOI Listing
February 2019

Changes in Screening Practices for Prediabetes and Diabetes Since the Recommendation for Hemoglobin A Testing.

Diabetes Care 2019 Feb 6. Epub 2019 Feb 6.

Department of Internal Medicine, University of Michigan, Ann Arbor, MI

Objective: Screening involves the presumptive identification of asymptomatic individuals at increased risk for unrecognized disease. We examined changes in screening practices for prediabetes and diabetes since January 2010, when HbA was first recommended as an option for screening and diagnosis.

Research Design And Methods: We studied members without diabetes of an HMO ≥45 years of age continuously enrolled for ≥3 years and assigned to primary care clinicians affiliated with a large academic health system. Read More

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http://dx.doi.org/10.2337/dc17-1726DOI Listing
February 2019

Dairy Product Intake and Risk of Type 2 Diabetes in EPIC-InterAct: A Mendelian Randomization Study.

Diabetes Care 2019 Feb 6. Epub 2019 Feb 6.

MRC Epidemiology Unit, University of Cambridge, Cambridge, U.K.

Objective: To estimate the causal association between intake of dairy products and incident type 2 diabetes.

Research Design And Methods: The analysis included 21,820 European individuals (9,686 diabetes cases) of the EPIC-InterAct case-cohort study. Participants were genotyped, and rs4988235 (LCT-12910C>T), a SNP for lactase persistence (LP) which enables digestion of dairy sugar, i. Read More

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http://dx.doi.org/10.2337/dc18-2034DOI Listing
February 2019
1 Read

Association of Insulin Dose, Cardiometabolic Risk Factors, and Cardiovascular Disease in Type 1 Diabetes During 30 Years of Follow-up in the DCCT/EDIC Study.

Diabetes Care 2019 Feb 6. Epub 2019 Feb 6.

University of California, San Diego, La Jolla, CA.

Objective: The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study demonstrated the beneficial effects of intensive therapy on atherosclerosis and clinical cardiovascular disease (CVD) outcomes. The current analyses evaluated the relationship between longitudinal changes in insulin dose and CVD risk factors and outcomes.

Research Design And Methods: A total of 1,441 participants were randomly assigned to intensive or conventional diabetes therapy during the DCCT. Read More

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http://dx.doi.org/10.2337/dc18-1574DOI Listing
February 2019

Effect of Glucose Improvement on Spirometric Maneuvers in Patients With Type 2 Diabetes: The Sweet Breath Study.

Diabetes Care 2019 Jan 31. Epub 2019 Jan 31.

Endocrinology and Nutrition Department, Hospital Universitari Arnau de Vilanova, Obesity, Diabetes and Metabolism Research Group (ODIM), Institut de Recerca Biomèdica de Lleida (IRBLleida), Universitat de Lleida, Lleida, Catalonia, Spain

Objective: Type 2 diabetes exerts a deleterious effect on lung function. However, it is unknown whether an improvement in glycemic control ameliorates pulmonary function.

Research Design And Methods: Prospective interventional study with 60 patients with type 2 diabetes and forced expiratory volume in 1 s (FEV1) ≤90% of predicted. Read More

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http://dx.doi.org/10.2337/dc18-1948DOI Listing
January 2019

The Impact of Obesity on the Incidence of Type 2 Diabetes Among Women With Polycystic Ovary Syndrome.

Diabetes Care 2019 Jan 31. Epub 2019 Jan 31.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Victoria, Australia

Objective: The nature of the independent relationship between polycystic ovary syndrome (PCOS) and type 2 diabetes remains unclear. Few studies have aimed to clarify this relationship independent of obesity in longitudinal population-based cohorts.

Research Design And Methods: We used the Australian Longitudinal Study on Women's Health (ALSWH) (2000-2015) database to estimate nationwide incidence rates and predictors of type 2 diabetes among women aged 18-42 using person-time and survival analysis. Read More

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http://dx.doi.org/10.2337/dc18-1738DOI Listing
January 2019
1 Read

Real-World Costs of Continuous Insulin Pump Therapy and Multiple Daily Injections for Type 1 Diabetes: A Population-Based and Propensity-Matched Cohort From the Swedish National Diabetes Register.

Diabetes Care 2019 Jan 31. Epub 2019 Jan 31.

Swedish Institute for Health Economics, Lund, Sweden

Objective: To investigate real-world costs of continuous insulin pump therapy compared with multiple daily injection (MDI) therapy for type 1 diabetes.

Research Design And Methods: Individuals with type 1 diabetes and pump therapy in the Swedish National Diabetes Register (NDR) since 2002 were eligible. Control subjects on MDI were matched 2:1 using time-varying propensity scores. Read More

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http://dx.doi.org/10.2337/dc18-1850DOI Listing
January 2019

Impact of Age of Onset, Puberty, and Glycemic Control Followed From Diagnosis on Incidence of Retinopathy in Type 1 Diabetes: The VISS Study.

Diabetes Care 2019 Jan 31. Epub 2019 Jan 31.

Departments of Endocrinology and Clinical and Experimental Medicine, Linköping University, Linköping, Östergötland, Sweden

Objective: To evaluate sex, age at diabetes onset, puberty, and HbA, with subjects followed from diabetes diagnosis and during different time periods, as risk factors for developing diabetic simplex and proliferative retinopathy.

Research Design And Methods: In a population-based observational study, HbA for 451 patients diagnosed with diabetes before 35 years of age during 1983-1987 in southeast Sweden was followed for up to 18-24 years from diagnosis. Long-term mean weighted HbA (wHbA) was calculated. Read More

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http://dx.doi.org/10.2337/dc18-1950DOI Listing
January 2019

Retinopathy Outcomes With Empagliflozin Versus Placebo in the EMPA-REG OUTCOME Trial.

Diabetes Care 2019 Jan 31. Epub 2019 Jan 31.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.2337/dc18-1355DOI Listing
January 2019

Home Use of Day and Night Hybrid Closed Loop Insulin Delivery in Very Young Children: A Multicenter 3-Week, Randomized Trial.

Diabetes Care 2019 Jan 28. Epub 2019 Jan 28.

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

Objective: We aimed to assess the feasibility and safety of hybrid closed loop insulin delivery in children with type 1 diabetes aged 1-7 years as well as evaluate the role of diluted insulin on glucose control.

Research Design And Methods: In an open-label, multicenter, multinational, randomized crossover study, 24 children with type 1 diabetes on insulin pump therapy (median age 5 years [interquartile range 3-6] and mean ± SD HbA 7.4 ± 0. Read More

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http://dx.doi.org/10.2337/dc18-1881DOI Listing
January 2019
1 Read

Maternal and Newborn Vitamin D-Binding Protein, Vitamin D Levels, Vitamin D Receptor Genotype, and Childhood Type 1 Diabetes.

Diabetes Care 2019 Jan 28. Epub 2019 Jan 28.

Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway.

Objective: Circumstantial evidence links 25-hydroxy vitamin D [25(OH)D], vitamin D-binding protein (DBP), vitamin D-associated genes, and type 1 diabetes (T1D), but no studies have jointly analyzed these. We aimed to investigate whether DBP levels during pregnancy or at birth were associated with offspring T1D and whether vitamin D pathway genetic variants modified associations between DBP, 25(OH)D, and T1D.

Research Design And Methods: From a cohort of >100,000 mother/child pairs, we analyzed 189 pairs where the child later developed T1D and 576 random control pairs. Read More

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http://dx.doi.org/10.2337/dc18-2176DOI Listing
January 2019

Frailty and Risk of Fractures in Patients With Type 2 Diabetes.

Diabetes Care 2019 Jan 28. Epub 2019 Jan 28.

Department of Medicine, McGill University, Montréal, Québec, Canada.

Objective: We aimed to explore whether frailty was associated with fracture risk and whether frailty could modify the propensity of type 2 diabetes toward increased risk of fractures.

Research Design And Methods: Data were from a prospective cohort study. Our primary outcome was time to the first incident clinical fragility fracture; secondary outcomes included time to hip fracture and to clinical spine fracture. Read More

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http://dx.doi.org/10.2337/dc18-1965DOI Listing
January 2019
1 Read

Cumulative Risk of End-Stage Renal Disease Among Patients With Type 2 Diabetes: A Nationwide Inception Cohort Study.

Diabetes Care 2019 Jan 28. Epub 2019 Jan 28.

Department of Social Research, Centre for Research Methods, University of Helsinki, Helsinki, Finland.

Objective: To estimate long-term cumulative risk of end-stage renal disease (ESRD) after diagnosis of type 2 diabetes.

Research Design And Methods: This nationwide population-based inception cohort study included 421,429 patients with type 2 diabetes diagnosed in 1990-2011; patients were followed until the end of 2013. Data linkage between several national health care registers in Finland, covering 100% of the population, enabled the inclusion of almost all inhabitants who started taking diabetes medication or were hospitalized for diabetes. Read More

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http://dx.doi.org/10.2337/dc18-1485DOI Listing
January 2019
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Sex Differences in Cardiovascular Risk Profile From Childhood to Midlife Between Individuals Who Did and Did Not Develop Diabetes at Follow-up: The Bogalusa Heart Study.

Diabetes Care 2019 Jan 28. Epub 2019 Jan 28.

Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA

Objective: Childhood and young adulthood may represent time periods in which cardiovascular risk factors (CVRFs) and their cumulative exposure lay the foundation for future risk of chronic diseases. We examined the longitudinal burden of CVRFs since childhood in men and women in whom diabetes did and did not develop at follow-up.

Research Design And Methods: We included 1,530 participants (mean [SD] follow-up time 33. Read More

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http://dx.doi.org/10.2337/dc18-2029DOI Listing
January 2019

Cardiovascular Risk Factor Burden in U.S. People With Incident Type 2 Diabetes Receiving Antidiabetic and Cardioprotective Therapies.

Diabetes Care 2019 Jan 24. Epub 2019 Jan 24.

Melbourne EpiCentre, University of Melbourne and Melbourne Health, Melbourne, Australia

Objective: Individualized treatment of patients with diabetes requires detailed evaluation of risk factor dynamics at the population level. This study evaluated the persistent glycemic and cardiovascular (CV) risk factor burden over 2 years after treatment intensification (TI).

Research Design And Methods: From U. Read More

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http://dx.doi.org/10.2337/dc18-1865DOI Listing
January 2019

Eye Care Utilization Among Insured People With Diabetes, U.S. 2010-2014.

Diabetes Care 2019 Jan 24. Epub 2019 Jan 24.

Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA.

Objective: Diabetic retinopathy (DR) is the leading cause of blindness among working-age adults, and although screening with eye exams is effective, screening rates are low. We evaluated eye exam visits over a 5-year period in a large population of insured patients 10-64 years of age with diabetes.

Research Design And Methods: We used claims data from IBM Watson Health to identify patients with diabetes and continuous insurance coverage from 2010 to 2014. Read More

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-082
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http://dx.doi.org/10.2337/dc18-0828DOI Listing
January 2019
3 Reads

Type 2 Diabetes, but Not Insulin (Analog) Treatment, Is Associated With More Advanced Stages of Breast Cancer: A National Linkage of Cancer and Pharmacy Registries.

Diabetes Care 2019 Jan 24. Epub 2019 Jan 24.

Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Research Institute, VU University Medical Centre, Amsterdam, the Netherlands.

Objective: To investigate whether women with type 2 diabetes (T2D) develop a more advanced stage of breast cancer and whether treatment with insulin (analogs) is associated with specific breast cancer characteristics.

Research Design And Methods: For this nested case-control study, women with breast cancer diagnosed in 2002-2014 were selected from the linked Netherlands Cancer Registry-PHARMO Database Network ( = 33,377). T2D was defined as receiving two or more dispensings of noninsulin blood glucose-lowering drugs prior to breast cancer diagnosis. Read More

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-214
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http://dx.doi.org/10.2337/dc18-2146DOI Listing
January 2019
6 Reads

A Randomized Controlled Trial on the Safety and Efficacy of Exenatide Therapy for the Inpatient Management of General Medicine and Surgery Patients With Type 2 Diabetes.

Diabetes Care 2019 Jan 24. Epub 2019 Jan 24.

Department of Medicine, Emory University, Atlanta, GA

Objective: This multicenter, open-label, randomized trial examined the safety and efficacy of exenatide alone or in combination with basal insulin in non-critically ill patients with type 2 diabetes (T2D).

Research Design And Methods: A total of 150 patients with blood glucose (BG) between 140 and 400 mg/dL, treated at home with diet, oral agents, or insulin at a total daily dose <0.5 units/kg, were randomized to exenatide alone (5 μg twice daily), exenatide plus basal insulin, or a basal-bolus insulin regimen. Read More

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-176
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http://dx.doi.org/10.2337/dc18-1760DOI Listing
January 2019
2 Reads

Material Need Insecurity and Its Concurrent Barriers to Diabetes Management Among Low-Income Latino Adults Receiving Medical Care.

Diabetes Care 2019 Jan 23. Epub 2019 Jan 23.

Program in Medical Education for the Latino Community (PRIME-LC), School of Medicine, University of California, Irvine, Irvine, CA

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-158
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http://dx.doi.org/10.2337/dc18-1583DOI Listing
January 2019
4 Reads

Comment on Mathew et al. Therapeutic Lifestyle Changes Improve HDL Function by Inhibiting Myeloperoxidase-Mediated Oxidation in Patients With Metabolic Syndrome. Diabetes Care 2018;41:2431-2437.

Diabetes Care 2019 Feb;42(2):e25

Division of Pharmacology, Otto Loewi Research Centre, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.2337/dc18-2026DOI Listing
February 2019
1 Read

Comment on Desai et al. Health Care Utilization and Burden of Diabetic Ketoacidosis in the U.S. Over the Past Decade: A Nationwide Analysis. Diabetes Care 2018;41:1631-1638.

Diabetes Care 2019 Feb;42(2):e24

Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA.

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http://dx.doi.org/10.2337/dc18-1424DOI Listing
February 2019
1 Read

Metabolic (Bariatric and Nonbariatric) Surgery for Type 2 Diabetes: A Personal Perspective Review.

Diabetes Care 2019 Feb;42(2):331-340

Division of Scientific Research Writing, Medwrite Medical Communications, Maiden Rock, WI.

: Metabolic surgery can cause amelioration, resolution, and possible cure of type 2 diabetes. Bariatric surgery is metabolic surgery. In the future, there will be metabolic surgery operations to treat type 2 diabetes that are not focused on weight loss. Read More

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http://dx.doi.org/10.2337/dc17-2654DOI Listing
February 2019
1 Read

Genetics Coming of Age in Type 1 Diabetes.

Diabetes Care 2019 Feb;42(2):189-191

Diabetes Program, Benaroya Research Institute, Seattle, WA

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http://dx.doi.org/10.2337/dci18-0039DOI Listing
February 2019
1 Read

Bariatric/Metabolic Surgery for Diabetes: Lessons From the Past and Present.

Diabetes Care 2019 Feb;42(2):186-188

Departments of Medicine and Surgery, Oregon Health & Science University, Portland, OR.

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http://dx.doi.org/10.2337/dci18-0031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341293PMC
February 2019
1 Read

Probing the Meaning of Persistent Propeptide Release in Type 1 Diabetes.

Diabetes Care 2019 Feb;42(2):183-185

Department of Surgery and Department of Pathology and Laboratory Medicine, BC Children's Hospital Research Institute and University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.2337/dci18-0054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341289PMC
February 2019
1 Read

in 2019-Who, Why, What, and How?

Authors:
Matthew C Riddle

Diabetes Care 2019 Feb;42(2):181-182

Division of Endocrinology, Diabetes, & Clinical Nutrition, Oregon Health & Science University, Portland, OR

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http://dx.doi.org/10.2337/dci18-0059DOI Listing
February 2019
1 Read

In This Issue of .

Authors:

Diabetes Care 2019 Feb;42(2):179-180

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http://dx.doi.org/10.2337/dc19-ti02DOI Listing
February 2019
1 Read

Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score.

Diabetes Care 2019 Jan 18. Epub 2019 Jan 18.

Center for Public Health Genomics, University of Virginia, Charlottesville, VA

Objective: Genetic risk scores (GRS) have been developed that differentiate individuals with type 1 diabetes from those with other forms of diabetes and are starting to be used for population screening; however, most studies were conducted in European-ancestry populations. This study identifies novel genetic variants associated with type 1 diabetes risk in African-ancestry participants and develops an African-specific GRS.

Research Design And Methods: We generated single nucleotide polymorphism (SNP) data with the ImmunoChip on 1,021 African-ancestry participants with type 1 diabetes and 2,928 control participants. Read More

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Source
http://care.diabetesjournals.org/lookup/doi/10.2337/dc18-172
Publisher Site
http://dx.doi.org/10.2337/dc18-1727DOI Listing
January 2019
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